Details for: PGM5

Gene ID: 5239

Symbol: PGM5

Ensembl ID: ENSG00000154330

Description: phosphoglucomutase 5

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 120.0937
    Cell Significance Index: -18.6800
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 71.9514
    Cell Significance Index: -18.2500
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 39.9684
    Cell Significance Index: -18.8700
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 38.2087
    Cell Significance Index: -15.7400
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 4.7465
    Cell Significance Index: -18.7300
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 4.0480
    Cell Significance Index: 58.2200
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 2.9110
    Cell Significance Index: 223.3900
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 2.5207
    Cell Significance Index: 80.7400
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: 1.9846
    Cell Significance Index: 16.6700
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 1.6907
    Cell Significance Index: 43.4600
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: 1.1928
    Cell Significance Index: 17.6100
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 1.0329
    Cell Significance Index: 204.9900
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: 0.9544
    Cell Significance Index: 99.3800
  • Cell Name: pulmonary interstitial fibroblast (CL0002241)
    Fold Change: 0.8736
    Cell Significance Index: 5.4100
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.7395
    Cell Significance Index: 15.3400
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.7349
    Cell Significance Index: 18.3700
  • Cell Name: enteric smooth muscle cell (CL0002504)
    Fold Change: 0.5986
    Cell Significance Index: 3.1500
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 0.5303
    Cell Significance Index: 20.0800
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.5160
    Cell Significance Index: 465.9200
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.4958
    Cell Significance Index: 933.5500
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 0.4173
    Cell Significance Index: 18.4600
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.3777
    Cell Significance Index: 37.3600
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.3087
    Cell Significance Index: 50.2200
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: 0.2750
    Cell Significance Index: 6.7100
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.2551
    Cell Significance Index: 139.3000
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.2522
    Cell Significance Index: 27.4400
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.2365
    Cell Significance Index: 107.3200
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.2298
    Cell Significance Index: 2.3800
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 0.1988
    Cell Significance Index: 13.3700
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.1857
    Cell Significance Index: 35.3400
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: 0.1388
    Cell Significance Index: 4.3900
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: 0.1383
    Cell Significance Index: 2.7000
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.1298
    Cell Significance Index: 176.5100
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.1282
    Cell Significance Index: 2.7300
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.1069
    Cell Significance Index: 6.4200
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.1061
    Cell Significance Index: 7.3400
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0953
    Cell Significance Index: 60.5500
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: 0.0591
    Cell Significance Index: 0.8900
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0543
    Cell Significance Index: 83.5700
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.0378
    Cell Significance Index: 7.5800
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 0.0251
    Cell Significance Index: 0.4300
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0246
    Cell Significance Index: 45.4300
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: 0.0089
    Cell Significance Index: 0.4500
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0020
    Cell Significance Index: -0.7200
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.0049
    Cell Significance Index: -0.1400
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.0091
    Cell Significance Index: -0.5600
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: -0.0091
    Cell Significance Index: -6.3000
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0150
    Cell Significance Index: -0.8400
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0204
    Cell Significance Index: -3.6800
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.0229
    Cell Significance Index: -1.0400
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0232
    Cell Significance Index: -16.9900
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0237
    Cell Significance Index: -3.4500
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0246
    Cell Significance Index: -18.2500
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0249
    Cell Significance Index: -18.8200
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0268
    Cell Significance Index: -3.6800
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: -0.0299
    Cell Significance Index: -13.2300
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0308
    Cell Significance Index: -19.2100
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0340
    Cell Significance Index: -19.1700
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.0522
    Cell Significance Index: -1.4900
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0603
    Cell Significance Index: -2.1200
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0677
    Cell Significance Index: -8.3300
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0680
    Cell Significance Index: -19.5600
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.0697
    Cell Significance Index: -1.5100
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0703
    Cell Significance Index: -7.1900
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0705
    Cell Significance Index: -1.1800
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0897
    Cell Significance Index: -18.9000
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.1062
    Cell Significance Index: -18.1400
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.1234
    Cell Significance Index: -15.8200
  • Cell Name: retinal bipolar neuron (CL0000748)
    Fold Change: -0.1369
    Cell Significance Index: -1.6600
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.1487
    Cell Significance Index: -19.2100
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.1648
    Cell Significance Index: -2.3600
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1710
    Cell Significance Index: -19.5900
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: -0.1748
    Cell Significance Index: -2.5100
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.1752
    Cell Significance Index: -20.4200
  • Cell Name: rod bipolar cell (CL0000751)
    Fold Change: -0.1797
    Cell Significance Index: -2.0600
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.2225
    Cell Significance Index: -11.5900
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.2225
    Cell Significance Index: -17.6300
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: -0.2286
    Cell Significance Index: -4.0400
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.2445
    Cell Significance Index: -15.0300
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: -0.2496
    Cell Significance Index: -3.2000
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.2600
    Cell Significance Index: -19.3800
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.2708
    Cell Significance Index: -5.9300
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.2723
    Cell Significance Index: -17.1600
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.3105
    Cell Significance Index: -16.1300
  • Cell Name: ON-bipolar cell (CL0000749)
    Fold Change: -0.3337
    Cell Significance Index: -3.7700
  • Cell Name: invaginating midget bipolar cell (CL4033034)
    Fold Change: -0.3383
    Cell Significance Index: -4.1800
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.3411
    Cell Significance Index: -17.9100
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.3558
    Cell Significance Index: -16.7200
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: -0.3769
    Cell Significance Index: -5.0800
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.3959
    Cell Significance Index: -18.4600
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.4139
    Cell Significance Index: -14.5000
  • Cell Name: endothelial cell of hepatic sinusoid (CL1000398)
    Fold Change: -0.4366
    Cell Significance Index: -4.1500
  • Cell Name: cone retinal bipolar cell (CL0000752)
    Fold Change: -0.4424
    Cell Significance Index: -3.4100
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.4448
    Cell Significance Index: -9.3100
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.4519
    Cell Significance Index: -13.3100
  • Cell Name: lung microvascular endothelial cell (CL2000016)
    Fold Change: -0.4597
    Cell Significance Index: -3.8900
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.5004
    Cell Significance Index: -17.3900
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.5023
    Cell Significance Index: -18.4400
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -0.5141
    Cell Significance Index: -10.9900
  • Cell Name: mural cell (CL0008034)
    Fold Change: -0.5200
    Cell Significance Index: -6.3300

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** PGM5 is a member of the phosphoglucomutase family, which catalyzes the interconversion of glucose-1-phosphate and glucose-6-phosphate. The enzyme is characterized by its ability to bind magnesium ions, which is essential for its catalytic activity. PGM5 is also involved in the regulation of cell adhesion and the formation of costamere complexes, which are critical for maintaining the structural integrity of muscle cells. Additionally, PGM5 is expressed in various tissues, including cardiac muscle cells, smooth muscle cells, and epithelial cells, suggesting its role in maintaining tissue homeostasis. **Pathways and Functions:** PGM5 is involved in several cellular pathways, including: 1. **Carbohydrate Metabolic Process:** PGM5 regulates the interconversion of glucose-1-phosphate and glucose-6-phosphate, which is essential for maintaining energy homeostasis in cells. 2. **Cell-Substrate Junction:** PGM5 is involved in the formation of costamere complexes, which are critical for maintaining the structural integrity of muscle cells. 3. **Cell Adhesion:** PGM5 regulates cell adhesion by interacting with other proteins, such as dystrophin-associated glycoprotein complex, which is essential for maintaining tissue homeostasis. 4. **Myofibril Assembly:** PGM5 is involved in the assembly of myofibrils, which are critical for muscle contraction and relaxation. **Clinical Significance:** Dysregulation of PGM5 has been implicated in various diseases, including: 1. **Muscular Dystrophy:** Mutations in the PGM5 gene have been associated with muscular dystrophy, a group of genetic disorders characterized by progressive muscle weakness and degeneration. 2. **Cardiac Arrhythmias:** Alterations in PGM5 expression have been linked to cardiac arrhythmias, which are abnormal heart rhythms that can lead to sudden death. 3. **Cancer:** PGM5 has been implicated in the development and progression of certain types of cancer, including colorectal and breast cancer. In conclusion, PGM5 is a critical enzyme involved in regulating carbohydrate metabolism, cell adhesion, and muscle function. Its dysregulation has been implicated in various diseases, highlighting the need for further research into its role in maintaining tissue homeostasis and its potential implications in disease prevention and treatment.

Genular Protein ID: 4270285626

Symbol: PGM5_HUMAN

Name: Phosphoglucomutase-related protein

UniProtKB Accession Codes:

Q15124 B1AM46 B4DLQ6 Q5VYV3 Q8N527 Q9UDH4

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 7 Ensembl 2 ExpressionAtlas 1 GO 18 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 InterPro 8 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 1 PDBsum 1 PIR 1 PRINTS 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 3 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 RefSeq 1 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 SwissPalm 1 TopDownProteomics 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15164053

Title: DNA sequence and analysis of human chromosome 9.

PubMed ID: 15164053

DOI: 10.1038/nature02465

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9342213

Title: Characterisation of the promoter which regulates expression of a phosphoglucomutase-related protein, a component of the dystrophin/utrophin cytoskeleton predominantly expressed in smooth muscle.

PubMed ID: 9342213

DOI: 10.1111/j.1432-1033.1997.00634.x

PubMed ID: 8631316

Title: A novel dystrophin/utrophin-associated protein is an enzymatically inactive member of the phosphoglucomutase superfamily.

PubMed ID: 8631316

DOI: 10.1111/j.1432-1033.1996.00103.x

PubMed ID: 8175905

Title: A novel phosphoglucomutase-related protein is concentrated in adherens junctions of muscle and nonmuscle cells.

PubMed ID: 8175905

DOI: 10.1242/jcs.107.1.159

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

Sequence Information:

  • Length: 567
  • Mass: 62225
  • Checksum: 00583A442977A025
  • Sequence:
    • MEGSPIPVLT VPTAPYEDQR PAGGGGLRRP TGLFEGQRNY LPNFIQSVLS SIDLRDRQGC 
TMVVGSDGRY FSRTAIEIVV QMAAANGIGR LIIGQNGILS TPAVSCIIRK IKAAGGIILT 
ASHCPGGPGG EFGVKFNVAN GGPAPDVVSD KIYQISKTIE EYAICPDLRI DLSRLGRQEF 
DLENKFKPFR VEIVDPVDIY LNLLRTIFDF HAIKGLLTGP SQLKIRIDAM HGVMGPYVRK 
VLCDELGAPA NSAINCVPLE DFGGQHPDPN LTYATTLLEA MKGGEYGFGA AFDADGDRYM 
ILGQNGFFVS PSDSLAIIAA NLSCIPYFRQ MGVRGFGRSM PTSMALDRVA KSMKVPVYET 
PAGWRFFSNL MDSGRCNLCG EESFGTGSDH LREKDGLWAV LVWLSIIAAR KQSVEEIVRD 
HWAKFGRHYY CRFDYEGLDP KTTYYIMRDL EALVTDKSFI GQQFAVGSHV YSVAKTDSFE 
YVDPVDGTVT KKQGLRIIFS DASRLIFRLS SSSGVRATLR LYAESYERDP SGHDQEPQAV 
LSPLIAIALK ISQIHERTGR RGPTVIT

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.