Details for: SERPINE1

Gene ID: 5054

Symbol: SERPINE1

Ensembl ID: ENSG00000106366

Description: serpin family E member 1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 75.8940
    Cell Significance Index: -19.2500
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 45.4912
    Cell Significance Index: -18.7400
  • Cell Name: prostate gland microvascular endothelial cell (CL2000059)
    Fold Change: 7.2307
    Cell Significance Index: 51.9300
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 6.7687
    Cell Significance Index: 194.0300
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 4.9163
    Cell Significance Index: -19.4000
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: 2.5380
    Cell Significance Index: 15.7700
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 2.3850
    Cell Significance Index: 40.1800
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 2.1718
    Cell Significance Index: 57.9900
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: 2.0087
    Cell Significance Index: 13.6100
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 1.6094
    Cell Significance Index: 28.4400
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.6124
    Cell Significance Index: 121.5300
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.4893
    Cell Significance Index: 60.1600
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: 0.4478
    Cell Significance Index: 6.6100
  • Cell Name: fibroblast of connective tissue of glandular part of prostate (CL1000305)
    Fold Change: 0.4463
    Cell Significance Index: 4.9300
  • Cell Name: fibroblast of breast (CL4006000)
    Fold Change: 0.4278
    Cell Significance Index: 2.6900
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: 0.3707
    Cell Significance Index: 2.2400
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.2822
    Cell Significance Index: 14.6600
  • Cell Name: pulmonary capillary endothelial cell (CL4028001)
    Fold Change: 0.2666
    Cell Significance Index: 3.6500
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.2646
    Cell Significance Index: 33.9300
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.2498
    Cell Significance Index: 34.3100
  • Cell Name: midzonal region hepatocyte (CL0019028)
    Fold Change: 0.2223
    Cell Significance Index: 1.2800
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 0.2174
    Cell Significance Index: 2.4700
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.1325
    Cell Significance Index: 23.8900
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.1134
    Cell Significance Index: 174.5600
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: 0.0663
    Cell Significance Index: 41.4200
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.0634
    Cell Significance Index: 0.9100
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.0582
    Cell Significance Index: 3.0300
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0365
    Cell Significance Index: 49.6900
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.0309
    Cell Significance Index: 3.6000
  • Cell Name: syncytiotrophoblast cell (CL0000525)
    Fold Change: 0.0116
    Cell Significance Index: 0.1100
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: -0.0019
    Cell Significance Index: -0.0300
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0052
    Cell Significance Index: -9.8600
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0080
    Cell Significance Index: -5.8900
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.0081
    Cell Significance Index: -0.9200
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0086
    Cell Significance Index: -15.8200
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0116
    Cell Significance Index: -7.3700
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: -0.0135
    Cell Significance Index: -5.9600
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.0165
    Cell Significance Index: -0.2300
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0172
    Cell Significance Index: -9.3900
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0178
    Cell Significance Index: -0.9000
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0190
    Cell Significance Index: -10.7000
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0233
    Cell Significance Index: -4.9000
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0234
    Cell Significance Index: -17.6900
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0264
    Cell Significance Index: -5.3000
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0274
    Cell Significance Index: -7.8900
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0281
    Cell Significance Index: -12.7700
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.0328
    Cell Significance Index: -0.6400
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0344
    Cell Significance Index: -3.5100
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0360
    Cell Significance Index: -12.9200
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0500
    Cell Significance Index: -8.5300
  • Cell Name: perivascular cell (CL4033054)
    Fold Change: -0.0606
    Cell Significance Index: -0.2800
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.0665
    Cell Significance Index: -4.2900
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.0800
    Cell Significance Index: -5.6600
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: -0.0816
    Cell Significance Index: -0.6700
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0994
    Cell Significance Index: -4.0700
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.1105
    Cell Significance Index: -14.2700
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.1111
    Cell Significance Index: -16.1500
  • Cell Name: embryonic fibroblast (CL2000042)
    Fold Change: -0.1150
    Cell Significance Index: -0.5500
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1404
    Cell Significance Index: -16.0900
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.1480
    Cell Significance Index: -17.4500
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: -0.1499
    Cell Significance Index: -1.3800
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.1546
    Cell Significance Index: -11.8600
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1858
    Cell Significance Index: -19.3500
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.1907
    Cell Significance Index: -5.3300
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.1979
    Cell Significance Index: -14.7500
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.2079
    Cell Significance Index: -5.6600
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.2496
    Cell Significance Index: -11.7300
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.2524
    Cell Significance Index: -16.9700
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.2974
    Cell Significance Index: -18.2800
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.3179
    Cell Significance Index: -19.4900
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.3354
    Cell Significance Index: -21.1400
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.3680
    Cell Significance Index: -20.6500
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.3697
    Cell Significance Index: -9.7200
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: -0.3794
    Cell Significance Index: -9.4600
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.3850
    Cell Significance Index: -17.9500
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.3916
    Cell Significance Index: -10.0700
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.3987
    Cell Significance Index: -18.0700
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.4057
    Cell Significance Index: -21.3000
  • Cell Name: fibroblast of connective tissue of nonglandular part of prostate (CL1000304)
    Fold Change: -0.4398
    Cell Significance Index: -4.8000
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.4415
    Cell Significance Index: -11.8300
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: -0.4455
    Cell Significance Index: -5.7100
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.4570
    Cell Significance Index: -15.8800
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: -0.4571
    Cell Significance Index: -9.3000
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.4733
    Cell Significance Index: -16.5800
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.4777
    Cell Significance Index: -21.1300
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: -0.4895
    Cell Significance Index: -7.0400
  • Cell Name: taste receptor cell (CL0000209)
    Fold Change: -0.5140
    Cell Significance Index: -5.9800
  • Cell Name: oral mucosa squamous cell (CL1001576)
    Fold Change: -0.5330
    Cell Significance Index: -4.5800
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.5350
    Cell Significance Index: -12.9600
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.5413
    Cell Significance Index: -19.8700
  • Cell Name: endothelial tip cell (CL0000704)
    Fold Change: -0.5488
    Cell Significance Index: -2.3600
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.5675
    Cell Significance Index: -18.5800
  • Cell Name: trophoblast giant cell (CL0002488)
    Fold Change: -0.5698
    Cell Significance Index: -4.1100
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.5701
    Cell Significance Index: -21.5900
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.5762
    Cell Significance Index: -18.3500
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: -0.5786
    Cell Significance Index: -6.0400
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.5914
    Cell Significance Index: -17.4200
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.5914
    Cell Significance Index: -17.3700
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.5957
    Cell Significance Index: -12.4700
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.6169
    Cell Significance Index: -10.3300

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** 1. **Serine protease inhibitor**: PAI-1 is a serine protease inhibitor that inhibits the activity of plasminogen activators, thereby regulating fibrinolysis and blood coagulation. 2. **Multiple cellular expressions**: SERPINE1 is expressed in various cell types, including fibroblasts, endothelial cells, and smooth muscle cells. 3. **Regulation by multiple signaling pathways**: SERPINE1 expression is regulated by multiple signaling pathways, including the circadian clock, and is responsive to various stimuli, such as inflammatory cytokines and growth factors. 4. **Involvement in various diseases**: SERPINE1 is involved in various diseases, including cancer, cardiovascular disease, and infectious diseases. **Pathways and Functions** 1. **Fibrinolysis and blood coagulation**: PAI-1 regulates fibrinolysis by inhibiting plasminogen activators, thereby preventing excessive fibrin degradation and promoting blood coagulation. 2. **Cellular migration and invasion**: PAI-1 inhibits cellular migration and invasion by regulating the activity of proteases involved in these processes. 3. **Inflammation**: PAI-1 modulates the inflammatory response by regulating the activity of proteases involved in inflammation. 4. **Circadian clock regulation**: SERPINE1 expression is regulated by the circadian clock, which influences its activity in various physiological processes. 5. **Regulation of signaling receptor activity**: PAI-1 regulates the activity of signaling receptors, including TGF-β receptors, which influences its involvement in various signaling pathways. **Clinical Significance** 1. **Cancer**: SERPINE1 is overexpressed in various cancers, including breast and prostate cancer, and is associated with poor prognosis and metastasis. 2. **Cardiovascular disease**: SERPINE1 is involved in the development of cardiovascular disease, including atherosclerosis and thrombosis. 3. **Infectious diseases**: SERPINE1 is involved in the regulation of immune responses to infectious diseases, including SARS-CoV-1. 4. **Regulation of wound healing**: SERPINE1 regulates wound healing by modulating the activity of proteases involved in the process. 5. **Therapeutic potential**: SERPINE1 is a potential target for therapeutic interventions in various diseases, including cancer, cardiovascular disease, and infectious diseases. In conclusion, SERPINE1 is a complex gene that plays a crucial role in regulating various physiological and pathological processes, including fibrinolysis, blood coagulation, cellular migration, and inflammation. Its dysregulation is involved in various diseases, including cancer, cardiovascular disease, and infectious diseases, making it a potential target for therapeutic interventions.

Genular Protein ID: 816311598

Symbol: PAI1_HUMAN

Name: Plasminogen activator inhibitor 1

UniProtKB Accession Codes:

P05121 B7Z4S0 F8WD53

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CPTAC 1 CTD 1 ChEMBL 1 ChiTaRS 1 ComplexPortal 3 DMDM 1 DNASU 1 DisGeNET 1 DisProt 1 DrugBank 11 DrugCentral 1 EMBL 29 Ensembl 1 EvolutionaryTrace 1 ExpressionAtlas 1 GO 38 Gene3D 2 GeneCards 1 GeneReviews 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyConnect 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 6 KEGG 1 MANE-Select 1 MEROPS 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OGP 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PDB 29 PDBsum 29 PIR 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 Reactome 5 RefSeq 1 SASBDB 1 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 2430793

Title: Endothelial plasminogen activator inhibitor (PAI): a new member of the Serpin gene family.

PubMed ID: 2430793

DOI: 10.1002/j.1460-2075.1986.tb04532.x

PubMed ID: 2820474

Title: Structure of the human plasminogen activator inhibitor 1 gene: nonrandom distribution of introns.

PubMed ID: 2820474

DOI: 10.1021/bi00387a004

PubMed ID: 3097076

Title: cDNA cloning of human plasminogen activator-inhibitor from endothelial cells.

PubMed ID: 3097076

DOI: 10.1172/jci112761

PubMed ID: 2612914

Title: Structure and expression of the human gene encoding plasminogen activator inhibitor, PAI-1.

PubMed ID: 2612914

DOI: 10.1016/0378-1119(89)90519-2

PubMed ID: 3262512

Title: The organization of the human-plasminogen-activator-inhibitor-1 gene. Implications on the evolution of the serine-protease inhibitor family.

PubMed ID: 3262512

DOI: 10.1111/j.1432-1033.1988.tb14320.x

PubMed ID: 3132455

Title: Human plasminogen activator inhibitor-1 gene. Promoter and structural gene nucleotide sequences.

PubMed ID: 3132455

DOI: 10.1016/s0021-9258(19)76517-x

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 12853948

Title: The DNA sequence of human chromosome 7.

PubMed ID: 12853948

DOI: 10.1038/nature01782

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 3092219

Title: Cloning and sequence of a cDNA coding for the human beta-migrating endothelial-cell-type plasminogen activator inhibitor.

PubMed ID: 3092219

DOI: 10.1073/pnas.83.18.6776

PubMed ID: 3025016

Title: Plasminogen activator inhibitor type-1: reactive center and amino-terminal heterogeneity determined by protein and cDNA sequencing.

PubMed ID: 3025016

DOI: 10.1016/0014-5793(86)81113-9

PubMed ID: 3026837

Title: cDNA cloning and expression in E. coli of a plasminogen activator inhibitor (PAI) related to a PAI produced by Hep G2 hepatoma cell.

PubMed ID: 3026837

DOI: 10.1016/0014-5793(87)81288-7

PubMed ID: 8481516

Title: Deficiency of plasma plasminogen activator inhibitor 1 results in hyperfibrinolytic bleeding.

PubMed ID: 8481516

PubMed ID: 7522053

Title: Identification of a PAI-1 binding site in vitronectin.

PubMed ID: 7522053

DOI: 10.1016/0167-4838(94)90166-x

PubMed ID: 9207454

Title: Human plasminogen activator inhibitor-1 (PAI-1) deficiency: characterization of a large kindred with a null mutation in the PAI-1 gene.

PubMed ID: 9207454

PubMed ID: 9168821

Title: Plasminogen activator inhibitor-1 represses integrin- and vitronectin-mediated cell migration independently of its function as an inhibitor of plasminogen activation.

PubMed ID: 9168821

DOI: 10.1006/excr.1997.3540

PubMed ID: 9175705

Title: Binding of urokinase to plasminogen activator inhibitor type-1 mediates cell adhesion and spreading.

PubMed ID: 9175705

DOI: 10.1242/jcs.110.9.1091

PubMed ID: 11384978

Title: The putative tumor suppressor LRP1B, a novel member of the low density lipoprotein (LDL) receptor family, exhibits both overlapping and distinct properties with the LDL receptor-related protein.

PubMed ID: 11384978

DOI: 10.1074/jbc.m102727200

PubMed ID: 15053742

Title: The mosaic receptor sorLA/LR11 binds components of the plasminogen-activating system and platelet-derived growth factor-BB similarly to LRP1 (low-density lipoprotein receptor-related protein), but mediates slow internalization of bound ligand.

PubMed ID: 15053742

DOI: 10.1042/bj20040149

PubMed ID: 15001579

Title: The low density lipoprotein receptor-related protein is a motogenic receptor for plasminogen activator inhibitor-1.

PubMed ID: 15001579

DOI: 10.1074/jbc.m313004200

PubMed ID: 15853774

Title: Matriptase-3 is a novel phylogenetically preserved membrane-anchored serine protease with broad serpin reactivity.

PubMed ID: 15853774

DOI: 10.1042/bj20050299

PubMed ID: 16862142

Title: Plasminogen activator inhibitor-1 is a critical downstream target of p53 in the induction of replicative senescence.

PubMed ID: 16862142

DOI: 10.1038/ncb1448

PubMed ID: 17912461

Title: Highly stable plasminogen activator inhibitor type one (VLHL PAI-1) protects fibrin clots from tissue plasminogen activator-mediated fibrinolysis.

PubMed ID: 17912461

PubMed ID: 18386027

Title: SERPINE1 (PAI-1) is deposited into keratinocyte migration 'trails' and required for optimal monolayer wound repair.

PubMed ID: 18386027

DOI: 10.1007/s00403-008-0845-2

PubMed ID: 22905912

Title: Resveratrol-induced changes of the human adipocyte secretion profile.

PubMed ID: 22905912

DOI: 10.1021/pr300539b

PubMed ID: 24041930

Title: Coagulation factor Xa induces an inflammatory signalling by activation of protease-activated receptors in human atrial tissue.

PubMed ID: 24041930

DOI: 10.1016/j.ejphar.2013.09.006

PubMed ID: 25808697

Title: Recombinant human plasminogen activator inhibitor-1 promotes cementogenic differentiation of human periodontal ligament stem cells.

PubMed ID: 25808697

DOI: 10.1089/ten.tea.2014.0399

PubMed ID: 27046084

Title: Recombinant human plasminogen activator inhibitor-1 accelerates odontoblastic differentiation of human stem cells from apical papilla.

PubMed ID: 27046084

DOI: 10.1089/ten.tea.2015.0273

PubMed ID: 28296156

Title: PAI1: a novel PP1-interacting protein that mediates human plasma's anti-apoptotic effect in endothelial cells.

PubMed ID: 28296156

DOI: 10.1111/jcmm.13127

PubMed ID: 29152572

Title: A null mutation in SERPINE1 protects against biological aging in humans.

PubMed ID: 29152572

DOI: 10.1126/sciadv.aao1617

PubMed ID: 1731226

Title: Structural basis of latency in plasminogen activator inhibitor-1.

PubMed ID: 1731226

DOI: 10.1038/355270a0

PubMed ID: 7552714

Title: Mechanisms contributing to the conformational and functional flexibility of plasminogen activator inhibitor-1.

PubMed ID: 7552714

DOI: 10.1038/nsb1095-891

PubMed ID: 9634700

Title: Interfering with the inhibitory mechanism of serpins: crystal structure of a complex formed between cleaved plasminogen activator inhibitor type 1 and a reactive-centre loop peptide.

PubMed ID: 9634700

DOI: 10.1016/s0969-2126(98)00064-1

PubMed ID: 10368279

Title: The active conformation of plasminogen activator inhibitor 1, a target for drugs to control fibrinolysis and cell adhesion.

PubMed ID: 10368279

DOI: 10.1016/s0969-2126(99)80018-5

PubMed ID: 10731421

Title: Plasminogen activator inhibitor 1. Structure of the native serpin, comparison to its other conformers and implications for serpin inactivation.

PubMed ID: 10731421

DOI: 10.1006/jmbi.2000.3604

PubMed ID: 9194591

Title: Mutational analysis of the genes encoding urokinase-type plasminogen activator (uPA) and its inhibitor PAI-1 in advanced ovarian cancer.

PubMed ID: 9194591

DOI: 10.1002/elps.1150180505

PubMed ID: 10391209

Title: Characterization of single-nucleotide polymorphisms in coding regions of human genes.

PubMed ID: 10391209

DOI: 10.1038/10290

Sequence Information:

  • Length: 402
  • Mass: 45060
  • Checksum: A2E181ED28DD6082
  • Sequence:
    • MQMSPALTCL VLGLALVFGE GSAVHHPPSY VAHLASDFGV RVFQQVAQAS KDRNVVFSPY 
GVASVLAMLQ LTTGGETQQQ IQAAMGFKID DKGMAPALRH LYKELMGPWN KDEISTTDAI 
FVQRDLKLVQ GFMPHFFRLF RSTVKQVDFS EVERARFIIN DWVKTHTKGM ISNLLGKGAV 
DQLTRLVLVN ALYFNGQWKT PFPDSSTHRR LFHKSDGSTV SVPMMAQTNK FNYTEFTTPD 
GHYYDILELP YHGDTLSMFI AAPYEKEVPL SALTNILSAQ LISHWKGNMT RLPRLLVLPK 
FSLETEVDLR KPLENLGMTD MFRQFQADFT SLSDQEPLHV AQALQKVKIE VNESGTVASS 
STAVIVSARM APEEIIMDRP FLFVVRHNPT GTVLFMGQVM EP

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.