Details for: SELP

Gene ID: 6403

Symbol: SELP

Ensembl ID: ENSG00000174175

Description: selectin P

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: amacrine cell (CL0000561)
    Fold Change: 3.32
    Marker Score: 10621
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: 1.78
    Marker Score: 2225.5
  • Cell Name: endocardial cell (CL0002350)
    Fold Change: 1.59
    Marker Score: 898
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: 1.46
    Marker Score: 2125
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 1.31
    Marker Score: 546
  • Cell Name: retinal blood vessel endothelial cell (CL0002585)
    Fold Change: 1.28
    Marker Score: 307
  • Cell Name: pulmonary artery endothelial cell (CL1001568)
    Fold Change: 1.28
    Marker Score: 1098
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 1.21
    Marker Score: 2047
  • Cell Name: lung microvascular endothelial cell (CL2000016)
    Fold Change: 1.11
    Marker Score: 237
  • Cell Name: retinal cone cell (CL0000573)
    Fold Change: 1.08
    Marker Score: 3090
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 1.04
    Marker Score: 251813
  • Cell Name: goblet cell (CL0000160)
    Fold Change: 1.01
    Marker Score: 6683
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71831
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48056
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30409
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2426
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.94
    Marker Score: 5349
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.92
    Marker Score: 2741
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5291
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.84
    Marker Score: 645
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.8
    Marker Score: 233
  • Cell Name: blood vessel endothelial cell (CL0000071)
    Fold Change: 0.79
    Marker Score: 798
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1265
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.78
    Marker Score: 709
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.77
    Marker Score: 398
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 0.76
    Marker Score: 677
  • Cell Name: prostate gland microvascular endothelial cell (CL2000059)
    Fold Change: 0.71
    Marker Score: 277
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.69
    Marker Score: 178
  • Cell Name: tracheal goblet cell (CL1000329)
    Fold Change: 0.6
    Marker Score: 1708
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.59
    Marker Score: 469
  • Cell Name: promyelocyte (CL0000836)
    Fold Change: 0.54
    Marker Score: 267
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.52
    Marker Score: 1062
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.52
    Marker Score: 311
  • Cell Name: endothelial cell of uterus (CL0009095)
    Fold Change: 0.52
    Marker Score: 1030
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.51
    Marker Score: 160
  • Cell Name: vein endothelial cell (CL0002543)
    Fold Change: 0.5
    Marker Score: 450
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.39
    Marker Score: 6105
  • Cell Name: vasa recta ascending limb cell (CL1001131)
    Fold Change: 0.37
    Marker Score: 99
  • Cell Name: endothelial cell of periportal hepatic sinusoid (CL0019021)
    Fold Change: 0.37
    Marker Score: 102
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.33
    Marker Score: 106
  • Cell Name: peritubular capillary endothelial cell (CL1001033)
    Fold Change: 0.33
    Marker Score: 76
  • Cell Name: platelet (CL0000233)
    Fold Change: 0.29
    Marker Score: 130
  • Cell Name: choroid plexus epithelial cell (CL0000706)
    Fold Change: 0.24
    Marker Score: 220
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: 0.24
    Marker Score: 132
  • Cell Name: endothelial cell of hepatic sinusoid (CL1000398)
    Fold Change: 0.23
    Marker Score: 50
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 0.23
    Marker Score: 350
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 0.22
    Marker Score: 117
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: 0.22
    Marker Score: 101
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: 0.21
    Marker Score: 68
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: 0.21
    Marker Score: 141
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.19
    Marker Score: 90
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.19
    Marker Score: 107
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.18
    Marker Score: 49
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.18
    Marker Score: 1562
  • Cell Name: CD34-positive, CD38-negative hematopoietic stem cell (CL0001024)
    Fold Change: 0.17
    Marker Score: 122
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: 0.17
    Marker Score: 2216.5
  • Cell Name: megakaryocyte progenitor cell (CL0000553)
    Fold Change: 0.16
    Marker Score: 46
  • Cell Name: renal beta-intercalated cell (CL0002201)
    Fold Change: 0.16
    Marker Score: 50
  • Cell Name: hematopoietic multipotent progenitor cell (CL0000837)
    Fold Change: 0.15
    Marker Score: 72
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.15
    Marker Score: 88
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.13
    Marker Score: 89
  • Cell Name: endothelial cell of sinusoid (CL0002262)
    Fold Change: 0.13
    Marker Score: 32
  • Cell Name: blood vessel smooth muscle cell (CL0019018)
    Fold Change: 0.13
    Marker Score: 33
  • Cell Name: endothelial cell of artery (CL1000413)
    Fold Change: 0.13
    Marker Score: 52
  • Cell Name: memory regulatory T cell (CL0002678)
    Fold Change: 0.12
    Marker Score: 43
  • Cell Name: primitive red blood cell (CL0002355)
    Fold Change: 0.12
    Marker Score: 91
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 0.12
    Marker Score: 41
  • Cell Name: leukocyte (CL0000738)
    Fold Change: 0.12
    Marker Score: 68
  • Cell Name: stem cell (CL0000034)
    Fold Change: 0.12
    Marker Score: 281
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.12
    Marker Score: 218
  • Cell Name: capillary endothelial cell (CL0002144)
    Fold Change: 0.11
    Marker Score: 121
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.11
    Marker Score: 47
  • Cell Name: parietal epithelial cell (CL1000452)
    Fold Change: 0.1
    Marker Score: 37
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: 0.1
    Marker Score: 69
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: 0.1
    Marker Score: 96
  • Cell Name: endothelial cell of lymphatic vessel (CL0002138)
    Fold Change: 0.1
    Marker Score: 62
  • Cell Name: glomerular endothelial cell (CL0002188)
    Fold Change: 0.1
    Marker Score: 25
  • Cell Name: alveolar capillary type 1 endothelial cell (CL4028002)
    Fold Change: 0.1
    Marker Score: 244
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 0.09
    Marker Score: 794
  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.09
    Marker Score: 53
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.09
    Marker Score: 355
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 0.09
    Marker Score: 90
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.09
    Marker Score: 373
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 0.09
    Marker Score: 55
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: 0.08
    Marker Score: 21
  • Cell Name: renal principal cell (CL0005009)
    Fold Change: 0.08
    Marker Score: 62
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.08
    Marker Score: 47
  • Cell Name: epithelial cell of glomerular capsule (CL1000450)
    Fold Change: 0.08
    Marker Score: 20
  • Cell Name: endothelial tip cell (CL0000704)
    Fold Change: 0.08
    Marker Score: 18
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 0.08
    Marker Score: 193
  • Cell Name: Unknown (CL0000003)
    Fold Change: 0.08
    Marker Score: 238
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.08
    Marker Score: 181
  • Cell Name: kidney interstitial fibroblast (CL1000692)
    Fold Change: 0.07
    Marker Score: 144
  • Cell Name: melanocyte (CL0000148)
    Fold Change: 0.07
    Marker Score: 30
  • Cell Name: secretory cell (CL0000151)
    Fold Change: 0.07
    Marker Score: 135
  • Cell Name: podocyte (CL0000653)
    Fold Change: 0.07
    Marker Score: 27
  • Cell Name: vasa recta descending limb cell (CL1001285)
    Fold Change: 0.07
    Marker Score: 20
  • Cell Name: stromal cell of lamina propria of small intestine (CL0009022)
    Fold Change: 0.07
    Marker Score: 16
  • Cell Name: smooth muscle cell of prostate (CL1000487)
    Fold Change: 0.07
    Marker Score: 18
  • Cell Name: basal cell of epithelium of trachea (CL1000348)
    Fold Change: 0.07
    Marker Score: 522

Hover over a box to see details here...

Hover over a box to see details here...

Hover over a box to see details here...

Other Information

**Key characteristics:** * Selp is a glycoprotein with a molecular weight of approximately 120 kDa. * It is a member of the selectin family of cell adhesion molecules, which are involved in cell adhesion, migration, and signaling. * Selp is expressed in high levels on the surface of endothelial cells, where it plays a key role in maintaining vascular integrity and preventing blood leakage. * It is also expressed on immune cells, where it helps to regulate the inflammatory response and immune cell trafficking. * Mutations in the SELP gene have been linked to several human diseases, including platelet disorders, vascular diseases, and cancer. **Pathways and functions:** * Selp binds to various ligands, including calcium ions, glycoproteins, and cell adhesion molecules. * It is involved in the regulation of platelet aggregation, as it facilitates the adhesion of platelets to each other and to the extracellular matrix. * It also plays a role in leukocyte migration by promoting the adhesion of immune cells to blood vessels. * Selp is also involved in the regulation of inflammation, as it can bind to lipopolysaccharide and promote the production of inflammatory cytokines. **Clinical significance:** * Mutations in the SELP gene have been linked to several human diseases, including platelet disorders, vascular diseases, and cancer. * The development of anti-SELP antibodies is being investigated as a potential treatment for these diseases. * By understanding the role of SELP in immune responses and platelet aggregation, researchers hope to develop new strategies for the treatment of these diseases.

Genular Protein ID: 4181201102

Symbol: LYAM3_HUMAN

Name: P-selectin

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 2466574

Title: Cloning of GMP-140, a granule membrane protein of platelets and endothelium: sequence similarity to proteins involved in cell adhesion and inflammation.

PubMed ID: 2466574

DOI: 10.1016/0092-8674(89)90636-3

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 7684381

Title: P-selectin is acylated with palmitic acid and stearic acid at cysteine 766 through a thioester linkage.

PubMed ID: 7684381

DOI: 10.1016/s0021-9258(18)82137-8

PubMed ID: 7585949

Title: A sulfated peptide segment at the amino terminus of PSGL-1 is critical for P-selectin binding.

PubMed ID: 7585949

DOI: 10.1016/0092-8674(95)90173-6

PubMed ID: 7585950

Title: PSGL-1 recognition of P-selectin is controlled by a tyrosine sulfation consensus at the PSGL-1 amino terminus.

PubMed ID: 7585950

DOI: 10.1016/0092-8674(95)90174-4

PubMed ID: 7559387

Title: Tyrosine sulfation of P-selectin glycoprotein ligand-1 is required for high affinity binding to P-selectin.

PubMed ID: 7559387

DOI: 10.1074/jbc.270.39.22677

PubMed ID: 11237770

Title: A new member of the sorting nexin family interacts with the C-terminus of P-selectin.

PubMed ID: 11237770

DOI: 10.1006/bbrc.2001.4467

PubMed ID: 15769472

Title: Functions of sorting nexin 17 domains and recognition motif for P-selectin trafficking.

PubMed ID: 15769472

DOI: 10.1016/j.jmb.2005.02.004

PubMed ID: 16263699

Title: Elucidation of N-glycosylation sites on human platelet proteins: a glycoproteomic approach.

PubMed ID: 16263699

DOI: 10.1074/mcp.m500324-mcp200

PubMed ID: 18606703

Title: Endoglycan, a member of the CD34 family of sialomucins, is a ligand for the vascular selectins.

PubMed ID: 18606703

DOI: 10.4049/jimmunol.181.2.1480

PubMed ID: 28011641

Title: Glycan Bound to the Selectin Low Affinity State Engages Glu-88 to Stabilize the High Affinity State under Force.

PubMed ID: 28011641

DOI: 10.1074/jbc.m116.767186

PubMed ID: 8901515

Title: Structure and function of the epidermal growth factor domain of P-selectin.

PubMed ID: 8901515

DOI: 10.1021/bi9610257

PubMed ID: 7505680

Title: Knowledge-based model building of proteins: concepts and examples.

PubMed ID: 7505680

DOI: 10.1002/pro.5560021103

PubMed ID: 11081633

Title: Insights into the molecular basis of leukocyte tethering and rolling revealed by structures of P- and E-selectin bound to SLe(X) and PSGL-1.

PubMed ID: 11081633

DOI: 10.1016/s0092-8674(00)00138-0

PubMed ID: 9668170

Title: The P-selectin gene is highly polymorphic: reduced frequency of the Pro715 allele carriers in patients with myocardial infarction.

PubMed ID: 9668170

DOI: 10.1093/hmg/7.8.1277

PubMed ID: 10391209

Title: Characterization of single-nucleotide polymorphisms in coding regions of human genes.

PubMed ID: 10391209

DOI: 10.1038/10290

PubMed ID: 14681304

Title: Polymorphism in the P-selectin and interleukin-4 genes as determinants of stroke: a population-based, prospective genetic analysis.

PubMed ID: 14681304

DOI: 10.1093/hmg/ddh039

Sequence Information:

  • Length: 830
  • Mass: 90820
  • Checksum: FC353F714B7A9F56
  • Sequence:
  • MANCQIAILY QRFQRVVFGI SQLLCFSALI SELTNQKEVA AWTYHYSTKA YSWNISRKYC 
    QNRYTDLVAI QNKNEIDYLN KVLPYYSSYY WIGIRKNNKT WTWVGTKKAL TNEAENWADN 
    EPNNKRNNED CVEIYIKSPS APGKWNDEHC LKKKHALCYT ASCQDMSCSK QGECLETIGN 
    YTCSCYPGFY GPECEYVREC GELELPQHVL MNCSHPLGNF SFNSQCSFHC TDGYQVNGPS 
    KLECLASGIW TNKPPQCLAA QCPPLKIPER GNMTCLHSAK AFQHQSSCSF SCEEGFALVG 
    PEVVQCTASG VWTAPAPVCK AVQCQHLEAP SEGTMDCVHP LTAFAYGSSC KFECQPGYRV 
    RGLDMLRCID SGHWSAPLPT CEAISCEPLE SPVHGSMDCS PSLRAFQYDT NCSFRCAEGF 
    MLRGADIVRC DNLGQWTAPA PVCQALQCQD LPVPNEARVN CSHPFGAFRY QSVCSFTCNE 
    GLLLVGASVL QCLATGNWNS VPPECQAIPC TPLLSPQNGT MTCVQPLGSS SYKSTCQFIC 
    DEGYSLSGPE RLDCTRSGRW TDSPPMCEAI KCPELFAPEQ GSLDCSDTRG EFNVGSTCHF 
    SCDNGFKLEG PNNVECTTSG RWSATPPTCK GIASLPTPGV QCPALTTPGQ GTMYCRHHPG 
    TFGFNTTCYF GCNAGFTLIG DSTLSCRPSG QWTAVTPACR AVKCSELHVN KPIAMNCSNL 
    WGNFSYGSIC SFHCLEGQLL NGSAQTACQE NGHWSTTVPT CQAGPLTIQE ALTYFGGAVA 
    STIGLIMGGT LLALLRKRFR QKDDGKCPLN PHSHLGTYGV FTNAAFDPSP

Genular Protein ID: 507542882

Symbol: Q6NUL9_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 829
  • Mass: 90776
  • Checksum: 5BDBFA23F02533EB
  • Sequence:
  • MANCQIAILY QRFQRVVFGI SQLLCFSALI SELTNQKEVA AWTYHYSTKA YSWNISRKYC 
    QNRYTDLVAI QNKNEIDYLN KVLPYYSSYY WIGIRKNNKT WTWVGTKKAL TNEAENWADN 
    EPNNKRNNED CVEIYIKSPS APGKWNDEHC LKKKHALCYT ASCQDMSCSK QGECLETIGN 
    YTCSCYPGFY GPECEYVREC GELELPQHVL MNCSHPLGNF SFNSQCSFHC TDGYQVNGPS 
    KLECLASGIW TNKPPQCLAA QCPPLKIPER GNMTCLHSAK AFQHQSSCSF SCEEGFALVG 
    PEVVQCTASG VWTAPAPVCK AVQCQHLEAP SEGTMDCVHP LTAFAYGSSC KFECQPGYRV 
    RGLDMLRCID SGHWSAPLPT CEAISCEPLE SPVHGSMDCS PSLRAFQYDT NCSFRCAEGF 
    MLRGADIVRC DNLGQWTAPA PVCQALQCQD LPVPNEARVN CSHPFGAFRY QSVCSFTCNE 
    GLLLVGASVL QCLATGNWNS VPPECQAIPC TPLLSPQNGT MTCVRPLGSS SYKSTCQFIC 
    DEGYSLSGPE RLDCTRSGRW TDSPPMCEAI KCPELFAPEQ GSLDCSDTRG EFNVGSTCHF 
    SCNNGFKLEG PNNVECTTSG RWSATPPTCK GIASLPTPGV QCPALTTPGQ GTMYCRHHPG 
    TFGFNTTCYF GCNAGFTLIG DSTLSCRPSG QWTAVTPACR AVKCSELHVN KPIAMNCSNL 
    WGNFSYGSIC SFHCLEGQLL NGSAQTACQE NGHWSTTVPT CQGPLTIQEA LTYFGGAVAS 
    TIGLIMGGTL LALLRKRFRQ KDDGKCPLNP HSHLGTYGVF TNAAFDPSP

Genular Protein ID: 556595853

Symbol: Q5R341_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 11181995

Title: The sequence of the human genome.

PubMed ID: 11181995

DOI: 10.1126/science.1058040

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

Sequence Information:

  • Length: 768
  • Mass: 84036
  • Checksum: 2CC77FDC30CCDF4A
  • Sequence:
  • MANCQIAILY QRFQRVVFGI SQLLCFSALI SELTNQKEVA AWTYHYSTKA YSWNISRKYC 
    QNRYTDLVAI QNKNEIDYLN KVLPYYSSYY WIGIRKNNKT WTWVGTKKAL TNEAENWADN 
    EPNNKRNNED CVEIYIKSPS APGKWNDEHC LKKKHALCYT ASCQDMSCSK QGECLETIGN 
    YTCSCYPGFY GPECEYVREC GELELPQHVL MNCSHPLGNF SFNSQCSFHC TDGYQVNGPS 
    KLECLASGIW TNKPPQCLAA QCPPLKIPER GNMTCLHSAK AFQHQSSCSF SCEEGFALVG 
    PEVVQCTASG VWTAPAPVCK AISCEPLESP VHGSMDCSPS LRAFQYDTNC SFRCAEGFML 
    RGADIVRCDN LGQWTAPAPV CQALQCQDLP VPNEARVNCS HPFGAFRYQS VCSFTCNEGL 
    LLVGASVLQC LATGNWNSVP PECQAIPCTP LLSPQNGTMT CVQPLGSSSY KSTCQFICDE 
    GYSLSGPERL DCTRSGRWTD SPPMCEAIKC PELFAPEQGS LDCSDTRGEF NVGSTCHFSC 
    DNGFKLEGPN NVECTTSGRW SATPPTCKGI ASLPTPGVQC PALTTPGQGT MYCRHHPGTF 
    GFNTTCYFGC NAGFTLIGDS TLSCRPSGQW TAVTPACRAV KCSELHVNKP IAMNCSNLWG 
    NFSYGSICSF HCLEGQLLNG SAQTACQENG HWSTTVPTCQ AGPLTIQEAL TYFGGAVAST 
    IGLIMGGTLL ALLRKRFRQK DDGKCPLNPH SHLGTYGVFT NAAFDPSP

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.