Details for: EML1

Gene ID: 2009

Symbol: EML1

Ensembl ID: ENSG00000066629

Description: EMAP like 1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 233.4369
    Cell Significance Index: -36.3100
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 143.6268
    Cell Significance Index: -36.4300
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 76.0184
    Cell Significance Index: -35.8900
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 75.2233
    Cell Significance Index: -30.5600
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 32.0191
    Cell Significance Index: -30.5700
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 29.4901
    Cell Significance Index: -36.3600
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 10.6279
    Cell Significance Index: -23.2600
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 9.2688
    Cell Significance Index: -36.5800
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 5.2603
    Cell Significance Index: 295.1800
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 4.1257
    Cell Significance Index: 182.4900
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 3.8593
    Cell Significance Index: 146.1400
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 3.0792
    Cell Significance Index: 194.0700
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 2.8256
    Cell Significance Index: 90.5000
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: 2.2981
    Cell Significance Index: 37.8700
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 2.2647
    Cell Significance Index: 138.8500
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 1.8877
    Cell Significance Index: 27.1500
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.7566
    Cell Significance Index: 352.3700
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 1.5429
    Cell Significance Index: 15.9800
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: 0.7014
    Cell Significance Index: 13.6900
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.5985
    Cell Significance Index: 45.9300
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.5880
    Cell Significance Index: 111.9000
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.5201
    Cell Significance Index: 186.5700
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 0.5095
    Cell Significance Index: 34.2600
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.4820
    Cell Significance Index: 333.3600
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 0.4773
    Cell Significance Index: 12.2700
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.3652
    Cell Significance Index: 72.4800
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.3546
    Cell Significance Index: 320.1400
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.3037
    Cell Significance Index: 30.0500
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.1240
    Cell Significance Index: 20.1600
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.1168
    Cell Significance Index: 74.1600
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.0657
    Cell Significance Index: 35.8800
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.0442
    Cell Significance Index: 2.3000
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 0.0017
    Cell Significance Index: 0.0200
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.0002
    Cell Significance Index: 0.0900
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0016
    Cell Significance Index: -2.9800
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.0042
    Cell Significance Index: -0.1200
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0183
    Cell Significance Index: -33.6700
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0192
    Cell Significance Index: -0.6800
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0210
    Cell Significance Index: -32.3000
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0219
    Cell Significance Index: -3.1800
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0220
    Cell Significance Index: -29.9300
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.0267
    Cell Significance Index: -0.7700
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: -0.0354
    Cell Significance Index: -3.8500
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0397
    Cell Significance Index: -29.1300
  • Cell Name: midget ganglion cell of retina (CL4023188)
    Fold Change: -0.0470
    Cell Significance Index: -0.4900
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0476
    Cell Significance Index: -35.2800
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0492
    Cell Significance Index: -37.2500
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: -0.0539
    Cell Significance Index: -23.8100
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0580
    Cell Significance Index: -7.9700
  • Cell Name: OFF midget ganglion cell (CL4033047)
    Fold Change: -0.0626
    Cell Significance Index: -0.7800
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0660
    Cell Significance Index: -41.2100
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0675
    Cell Significance Index: -38.0500
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.0720
    Cell Significance Index: -1.8000
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.1082
    Cell Significance Index: -31.1200
  • Cell Name: photoreceptor cell (CL0000210)
    Fold Change: -0.1121
    Cell Significance Index: -1.5800
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.1204
    Cell Significance Index: -21.7000
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.1325
    Cell Significance Index: -16.9800
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.1374
    Cell Significance Index: -6.2300
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.1579
    Cell Significance Index: -26.9600
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.1858
    Cell Significance Index: -11.4200
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1954
    Cell Significance Index: -41.1600
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.2278
    Cell Significance Index: -28.0100
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.2366
    Cell Significance Index: -12.4200
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.2499
    Cell Significance Index: -29.1200
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.2602
    Cell Significance Index: -29.8200
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.2611
    Cell Significance Index: -33.7300
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.2615
    Cell Significance Index: -5.6700
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.2660
    Cell Significance Index: -27.1800
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: -0.2738
    Cell Significance Index: -18.9400
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.3259
    Cell Significance Index: -10.6700
  • Cell Name: ON midget ganglion cell (CL4033046)
    Fold Change: -0.3304
    Cell Significance Index: -4.1700
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.3325
    Cell Significance Index: -10.5900
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.3334
    Cell Significance Index: -34.7100
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.3596
    Cell Significance Index: -7.4600
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.3680
    Cell Significance Index: -17.1600
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.3792
    Cell Significance Index: -5.4300
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: -0.3923
    Cell Significance Index: -23.5500
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.4244
    Cell Significance Index: -33.6100
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.4282
    Cell Significance Index: -9.3800
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.4751
    Cell Significance Index: -35.4100
  • Cell Name: radial glial cell (CL0000681)
    Fold Change: -0.5443
    Cell Significance Index: -3.2300
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.5685
    Cell Significance Index: -36.6800
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.5730
    Cell Significance Index: -26.9300
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.6099
    Cell Significance Index: -31.6800
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.6426
    Cell Significance Index: -22.5100
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.6961
    Cell Significance Index: -11.6500
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.6981
    Cell Significance Index: -24.2600
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: -0.7536
    Cell Significance Index: -6.2200
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.7838
    Cell Significance Index: -15.7400
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.7885
    Cell Significance Index: -8.5900
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.7906
    Cell Significance Index: -21.1100
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.7994
    Cell Significance Index: -22.3400
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.8519
    Cell Significance Index: -21.2500
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -0.8524
    Cell Significance Index: -18.2200
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.9098
    Cell Significance Index: -45.9800
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.9102
    Cell Significance Index: -21.8300
  • Cell Name: decidual cell (CL2000002)
    Fold Change: -0.9188
    Cell Significance Index: -14.7400
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.9211
    Cell Significance Index: -19.5500
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.9250
    Cell Significance Index: -18.2900
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.9531
    Cell Significance Index: -19.9500

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** EML1 is a gene that belongs to the echinoderm microtubule-associated protein (EMAP) family, which is characterized by its ability to bind microtubules. This binding capacity is crucial for various cellular processes, including microtubule organization, cytoskeleton organization, and mitotic spindle formation. EML1 is significantly expressed in various cell types, including photoreceptor cells, OFF retinal ganglion cells, kidney capillary endothelial cells, and colon goblet cells. These cells are involved in different physiological processes, such as vision, immune response, and epithelial barrier function. **Pathways and Functions:** EML1 is involved in several cellular pathways, including: 1. **Microtubule organization and cytoskeleton organization**: EML1's ability to bind microtubules is essential for maintaining the structural integrity of the cytoskeleton and regulating microtubule dynamics. 2. **Mitotic spindle formation and organization**: EML1 plays a crucial role in the formation and organization of the mitotic spindle, which is essential for cell division and cytokinesis. 3. **Neuroblast proliferation and differentiation**: EML1 is involved in the regulation of neuroblast proliferation and differentiation, which is critical for brain development and neural function. 4. **Hematopoietic progenitor cell differentiation**: EML1 is also implicated in the differentiation of hematopoietic progenitor cells, which is essential for blood cell development and immune function. 5. **Protein binding and tubulin binding**: EML1's ability to bind proteins and tubulins is crucial for its functions in microtubule organization and cytoskeleton organization. **Clinical Significance:** EML1's involvement in various cellular processes makes it a potential target for therapeutic interventions. For example: 1. **Brain development disorders**: Alterations in EML1 expression have been linked to brain development disorders, such as intellectual disability and autism spectrum disorder. 2. **Cancer**: EML1's role in microtubule organization and cytoskeleton organization makes it a potential target for cancer therapy. 3. **Neurological disorders**: EML1's involvement in neuroblast proliferation and differentiation makes it a potential target for the treatment of neurological disorders, such as Alzheimer's disease and Parkinson's disease. 4. **Immune system disorders**: EML1's role in hematopoietic progenitor cell differentiation makes it a potential target for the treatment of immune system disorders, such as leukemia and lymphoma. In conclusion, EML1 is a gene of unparalleled complexity, with far-reaching implications for our understanding of cell biology and immunology. Further research is needed to fully elucidate its functions and potential therapeutic applications.

Genular Protein ID: 2532223086

Symbol: EMAL1_HUMAN

Name: Echinoderm microtubule-associated protein-like 1

UniProtKB Accession Codes:

O00423 Q86U15 Q8N536 Q8N5C4 Q8WWL6

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 1 CPTAC 1 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 25 Ensembl 2 EvolutionaryTrace 1 ExpressionAtlas 1 GO 14 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HPA 1 InParanoid 1 IntAct 1 InterPro 6 KEGG 1 MANE-Select 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PDB 1 PDBsum 1 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 RNAct 1 RefSeq 2 SMART 1 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9226380

Title: Isolation of a novel human homologue of the gene coding for echinoderm microtubule-associated protein (EMAP) from the Usher syndrome type 1a locus at 14q32.

PubMed ID: 9226380

DOI: 10.1006/geno.1997.4779

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 10521658

Title: Sequence and expression patterns of a human EMAP-related protein-2 (HuEMAP-2).

PubMed ID: 10521658

DOI: 10.1016/s0378-1119(99)00335-2

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25740311

Title: Microtubule association of EML proteins and the EML4-ALK variant 3 oncoprotein require an N-terminal trimerization domain.

PubMed ID: 25740311

DOI: 10.1042/bj20150039

PubMed ID: 24859200

Title: Mutations in Eml1 lead to ectopic progenitors and neuronal heterotopia in mouse and human.

PubMed ID: 24859200

DOI: 10.1038/nn.3729

PubMed ID: 28556411

Title: The genetic landscape of familial congenital hydrocephalus.

PubMed ID: 28556411

DOI: 10.1002/ana.24964

PubMed ID: 24706829

Title: Crystal structure of EML1 reveals the basis for Hsp90 dependence of oncogenic EML4-ALK by disruption of an atypical beta-propeller domain.

PubMed ID: 24706829

DOI: 10.1073/pnas.1322892111

Sequence Information:

  • Length: 815
  • Mass: 89861
  • Checksum: A1476F75F3537205
  • Sequence:
    • MEDGFSSYSS LYDTSSLLQF CNDDSASAAS SMEVTDRIAS LEQRVQMQED DIQLLKSALA 
DVVRRLNITE EQQAVLNRKG PTKARPLMQT LPLRTTVNNG TVLPKKPTGS LPSPSGVRKE 
TAVPATKSNI KRTSSSERVS PGGRRESNGD SRGNRNRTGS TSSSSSGKKN SESKPKEPVF 
SAEEGYVKMF LRGRPVTMYM PKDQVDSYSL EAKVELPTKR LKLEWVYGYR GRDCRNNLYL 
LPTGETVYFI ASVVVLYNVE EQLQRHYAGH NDDVKCLAVH PDRITIATGQ VAGTSKDGKQ 
LPPHVRIWDS VTLNTLHVIG IGFFDRAVTC IAFSKSNGGT NLCAVDDSND HVLSVWDWQK 
EEKLADVKCS NEAVFAADFH PTDTNIIVTC GKSHLYFWTL EGSSLNKKQG LFEKQEKPKF 
VLCVTFSENG DTITGDSSGN ILVWGKGTNR ISYAVQGAHE GGIFALCMLR DGTLVSGGGK 
DRKLISWSGN YQKLRKTEIP EQFGPIRTVA EGKGDVILIG TTRNFVLQGT LSGDFTPITQ 
GHTDELWGLA IHASKSQFLT CGHDKHATLW DAVGHRPVWD KIIEDPAQSS GFHPSGSVVA 
VGTLTGRWFV FDTETKDLVT VHTDGNEQLS VMRYSPDGNF LAIGSHDNCI YIYGVSDNGR 
KYTRVGKCSG HSSFITHLDW SVNSQFLVSN SGDYEILYWV PSACKQVVSV ETTRDIEWAT 
YTCTLGFHVF GVWPEGSDGT DINAVCRAHE KKLLSTGDDF GKVHLFSYPC SQFRAPSHIY 
GGHSSHVTNV DFLCEDSHLI STGGKDTSIM QWRVI

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.