Details for: EML1

Gene ID: 2009

Symbol: EML1

Ensembl ID: ENSG00000066629

Description: EMAP like 1

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: photoreceptor cell (CL0000210)
    Fold Change: 2.35
    Marker Score: 1770
  • Cell Name: OFF retinal ganglion cell (CL4023033)
    Fold Change: 1.92
    Marker Score: 804
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 1.85
    Marker Score: 578
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 1.72
    Marker Score: 14775
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 1.65
    Marker Score: 15671
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.59
    Marker Score: 1153
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 1.54
    Marker Score: 917
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 1.5
    Marker Score: 446
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 1.48
    Marker Score: 2285
  • Cell Name: mural cell (CL0008034)
    Fold Change: 1.47
    Marker Score: 168353
  • Cell Name: ON retinal ganglion cell (CL4023032)
    Fold Change: 1.43
    Marker Score: 391
  • Cell Name: neuron (CL0000540)
    Fold Change: 1.41
    Marker Score: 5748
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: 1.4
    Marker Score: 5786.5
  • Cell Name: endothelial cell of pericentral hepatic sinusoid (CL0019022)
    Fold Change: 1.39
    Marker Score: 1493
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 1.35
    Marker Score: 858
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.29
    Marker Score: 79581
  • Cell Name: central nervous system macrophage (CL0000878)
    Fold Change: 1.25
    Marker Score: 621
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.23
    Marker Score: 19267
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: 1.21
    Marker Score: 9279
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 1.2
    Marker Score: 352
  • Cell Name: cerebral cortex neuron (CL0010012)
    Fold Change: 1.2
    Marker Score: 3416
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 1.16
    Marker Score: 10904
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 1.14
    Marker Score: 4783.5
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 1.14
    Marker Score: 43186.5
  • Cell Name: mesangial cell (CL0000650)
    Fold Change: 1.11
    Marker Score: 1335
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 1.1
    Marker Score: 2587
  • Cell Name: A2 amacrine cell (CL0004219)
    Fold Change: 1.09
    Marker Score: 347
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 1.09
    Marker Score: 2223
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: 1.08
    Marker Score: 16133.5
  • Cell Name: endothelial cell of periportal hepatic sinusoid (CL0019021)
    Fold Change: 1.04
    Marker Score: 287
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 1.03
    Marker Score: 785
  • Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 1.02
    Marker Score: 3932
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71779
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48003.5
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30405
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.97
    Marker Score: 500
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.96
    Marker Score: 454
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.95
    Marker Score: 32235.5
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: 0.95
    Marker Score: 1384
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 0.95
    Marker Score: 9828
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2411
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: 0.94
    Marker Score: 3248
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.93
    Marker Score: 385.5
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.92
    Marker Score: 5536
  • Cell Name: cerebellar granule cell precursor (CL0002362)
    Fold Change: 0.92
    Marker Score: 515
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.92
    Marker Score: 368
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2733
  • Cell Name: peritubular capillary endothelial cell (CL1001033)
    Fold Change: 0.91
    Marker Score: 212
  • Cell Name: brainstem motor neuron (CL2000047)
    Fold Change: 0.91
    Marker Score: 526
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.89
    Marker Score: 321
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.89
    Marker Score: 5076
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5295
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 0.84
    Marker Score: 31132.5
  • Cell Name: epithelial cell of lower respiratory tract (CL0002632)
    Fold Change: 0.83
    Marker Score: 3470.5
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 0.83
    Marker Score: 2355.5
  • Cell Name: pyramidal neuron (CL0000598)
    Fold Change: 0.82
    Marker Score: 1381
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.82
    Marker Score: 1795
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.8
    Marker Score: 384
  • Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
    Fold Change: 0.8
    Marker Score: 6964
  • Cell Name: enterocyte of colon (CL1000347)
    Fold Change: 0.8
    Marker Score: 1232
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1261
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: 0.77
    Marker Score: 17265
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.77
    Marker Score: 699
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.75
    Marker Score: 390
  • Cell Name: alveolar capillary type 2 endothelial cell (CL4028003)
    Fold Change: 0.75
    Marker Score: 1085
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 0.75
    Marker Score: 15955
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 0.75
    Marker Score: 14823
  • Cell Name: glomerular endothelial cell (CL0002188)
    Fold Change: 0.73
    Marker Score: 186
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.72
    Marker Score: 435
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 0.71
    Marker Score: 242
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.7
    Marker Score: 227
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.69
    Marker Score: 178
  • Cell Name: germ cell (CL0000586)
    Fold Change: 0.67
    Marker Score: 1176
  • Cell Name: capillary endothelial cell (CL0002144)
    Fold Change: 0.67
    Marker Score: 716
  • Cell Name: smooth muscle cell of large intestine (CL1000279)
    Fold Change: 0.65
    Marker Score: 247
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 0.64
    Marker Score: 573
  • Cell Name: stromal cell of lamina propria of small intestine (CL0009022)
    Fold Change: 0.63
    Marker Score: 142
  • Cell Name: type EC enteroendocrine cell (CL0000577)
    Fold Change: 0.63
    Marker Score: 593
  • Cell Name: kidney interstitial fibroblast (CL1000692)
    Fold Change: 0.63
    Marker Score: 1205
  • Cell Name: lung ciliated cell (CL1000271)
    Fold Change: 0.63
    Marker Score: 297
  • Cell Name: multi-ciliated epithelial cell (CL0005012)
    Fold Change: 0.62
    Marker Score: 1177
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.62
    Marker Score: 409
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 0.6
    Marker Score: 522
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: 0.59
    Marker Score: 154
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: 0.59
    Marker Score: 1413
  • Cell Name: alveolar capillary type 1 endothelial cell (CL4028002)
    Fold Change: 0.58
    Marker Score: 1473
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.58
    Marker Score: 255
  • Cell Name: adventitial cell (CL0002503)
    Fold Change: 0.57
    Marker Score: 141
  • Cell Name: vein endothelial cell (CL0002543)
    Fold Change: 0.56
    Marker Score: 510
  • Cell Name: retinal blood vessel endothelial cell (CL0002585)
    Fold Change: 0.56
    Marker Score: 135
  • Cell Name: neural progenitor cell (CL0011020)
    Fold Change: 0.56
    Marker Score: 2169
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.56
    Marker Score: 148
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.56
    Marker Score: 444
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.55
    Marker Score: 173
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.55
    Marker Score: 251
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 0.52
    Marker Score: 532
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: 0.52
    Marker Score: 1855
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 0.52
    Marker Score: 119
  • Cell Name: enteric smooth muscle cell (CL0002504)
    Fold Change: 0.52
    Marker Score: 1215.5
  • Cell Name: endothelial cell of sinusoid (CL0002262)
    Fold Change: 0.52
    Marker Score: 125

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Other Information

**Key characteristics:** - EML1 is a transmembrane protein with a molecular weight of approximately 120 kDa. - It is expressed in a variety of cell types, including neurons, endothelial cells, and cancer cells. - EML1 is a microtubule-associated protein that is involved in the organization and stability of the microtubule cytoskeleton. - It is also involved in the regulation of cell migration, neurite outgrowth, and synapse formation. **Pathways and functions:** - EML1 is involved in the regulation of neuroblast proliferation. - It is expressed in neural stem cells and is essential for their survival and differentiation into neurons. - EML1 also plays a role in the development of the blood-brain barrier. - It is involved in the regulation of blood-brain barrier function and is a target for neurodegenerative diseases. **Clinical significance:** - Mutations in EML1 have been linked to a number of human diseases, including autism, schizophrenia, and Alzheimer's disease. - These mutations can disrupt the normal function of EML1 and lead to the development of these neurological disorders. - Therefore, EML1 is a promising target for the treatment of neurodegenerative diseases.

Genular Protein ID: 2532223086

Symbol: EMAL1_HUMAN

Name: Echinoderm microtubule-associated protein-like 1

UniProtKB Accession Codes:

O00423 Q86U15 Q8N536 Q8N5C4 Q8WWL6

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 1 CPTAC 1 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 25 EPD 1 Ensembl 2 ExpressionAtlas 1 GO 14 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PDB 2 PDBsum 1 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 RNAct 1 RefSeq 2 SAM 1 SMART 1 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 TreeFam 1 UCSC 1 UniProtKB 2 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9226380

Title: Isolation of a novel human homologue of the gene coding for echinoderm microtubule-associated protein (EMAP) from the Usher syndrome type 1a locus at 14q32.

PubMed ID: 9226380

DOI: 10.1006/geno.1997.4779

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 10521658

Title: Sequence and expression patterns of a human EMAP-related protein-2 (HuEMAP-2).

PubMed ID: 10521658

DOI: 10.1016/s0378-1119(99)00335-2

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25740311

Title: Microtubule association of EML proteins and the EML4-ALK variant 3 oncoprotein require an N-terminal trimerization domain.

PubMed ID: 25740311

DOI: 10.1042/bj20150039

PubMed ID: 24859200

Title: Mutations in Eml1 lead to ectopic progenitors and neuronal heterotopia in mouse and human.

PubMed ID: 24859200

DOI: 10.1038/nn.3729

PubMed ID: 28556411

Title: The genetic landscape of familial congenital hydrocephalus.

PubMed ID: 28556411

DOI: 10.1002/ana.24964

PubMed ID: 24706829

Title: Crystal structure of EML1 reveals the basis for Hsp90 dependence of oncogenic EML4-ALK by disruption of an atypical beta-propeller domain.

PubMed ID: 24706829

DOI: 10.1073/pnas.1322892111

Sequence Information:

  • Length: 815
  • Mass: 89861
  • Checksum: A1476F75F3537205
  • Sequence:
    • MEDGFSSYSS LYDTSSLLQF CNDDSASAAS SMEVTDRIAS LEQRVQMQED DIQLLKSALA 
DVVRRLNITE EQQAVLNRKG PTKARPLMQT LPLRTTVNNG TVLPKKPTGS LPSPSGVRKE 
TAVPATKSNI KRTSSSERVS PGGRRESNGD SRGNRNRTGS TSSSSSGKKN SESKPKEPVF 
SAEEGYVKMF LRGRPVTMYM PKDQVDSYSL EAKVELPTKR LKLEWVYGYR GRDCRNNLYL 
LPTGETVYFI ASVVVLYNVE EQLQRHYAGH NDDVKCLAVH PDRITIATGQ VAGTSKDGKQ 
LPPHVRIWDS VTLNTLHVIG IGFFDRAVTC IAFSKSNGGT NLCAVDDSND HVLSVWDWQK 
EEKLADVKCS NEAVFAADFH PTDTNIIVTC GKSHLYFWTL EGSSLNKKQG LFEKQEKPKF 
VLCVTFSENG DTITGDSSGN ILVWGKGTNR ISYAVQGAHE GGIFALCMLR DGTLVSGGGK 
DRKLISWSGN YQKLRKTEIP EQFGPIRTVA EGKGDVILIG TTRNFVLQGT LSGDFTPITQ 
GHTDELWGLA IHASKSQFLT CGHDKHATLW DAVGHRPVWD KIIEDPAQSS GFHPSGSVVA 
VGTLTGRWFV FDTETKDLVT VHTDGNEQLS VMRYSPDGNF LAIGSHDNCI YIYGVSDNGR 
KYTRVGKCSG HSSFITHLDW SVNSQFLVSN SGDYEILYWV PSACKQVVSV ETTRDIEWAT 
YTCTLGFHVF GVWPEGSDGT DINAVCRAHE KKLLSTGDDF GKVHLFSYPC SQFRAPSHIY 
GGHSSHVTNV DFLCEDSHLI STGGKDTSIM QWRVI

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.