Details for: KDR

Gene ID: 3791

Symbol: KDR

Ensembl ID: ENSG00000128052

Description: kinase insert domain receptor

Associated with

  • Disease
    (R-HSA-1643685)
  • Diseases of signal transduction by growth factor receptors and second messengers
    (R-HSA-5663202)
  • Extracellular matrix organization
    (R-HSA-1474244)
  • Integrin cell surface interactions
    (R-HSA-216083)
  • Neurophilin interactions with vegf and vegfr
    (R-HSA-194306)
  • Signaling by membrane-tethered fusions of pdgfra or pdgfrb
    (R-HSA-9673768)
  • Signaling by pdgfr in disease
    (R-HSA-9671555)
  • Signaling by receptor tyrosine kinases
    (R-HSA-9006934)
  • Signaling by vegf
    (R-HSA-194138)
  • Signal transduction
    (R-HSA-162582)
  • Vegfa-vegfr2 pathway
    (R-HSA-4420097)
  • Vegf binds to vegfr leading to receptor dimerization
    (R-HSA-195399)
  • Vegf ligand-receptor interactions
    (R-HSA-194313)
  • Vegfr2 mediated cell proliferation
    (R-HSA-5218921)
  • Angiogenesis
    (GO:0001525)
  • Atp binding
    (GO:0005524)
  • Blood vessel endothelial cell differentiation
    (GO:0060837)
  • Branching involved in blood vessel morphogenesis
    (GO:0001569)
  • Cadherin binding
    (GO:0045296)
  • Calcium-mediated signaling using intracellular calcium source
    (GO:0035584)
  • Calcium ion homeostasis
    (GO:0055074)
  • Cell fate commitment
    (GO:0045165)
  • Cell migration
    (GO:0016477)
  • Cell migration involved in sprouting angiogenesis
    (GO:0002042)
  • Cellular response to hydrogen sulfide
    (GO:1904881)
  • Cellular response to vascular endothelial growth factor stimulus
    (GO:0035924)
  • Coreceptor activity
    (GO:0015026)
  • Embryonic hemopoiesis
    (GO:0035162)
  • Endocardium development
    (GO:0003157)
  • Endothelial cell differentiation
    (GO:0045446)
  • Endothelium development
    (GO:0003158)
  • Epithelial cell maturation
    (GO:0002070)
  • Epithelial cell proliferation
    (GO:0050673)
  • Growth factor binding
    (GO:0019838)
  • Hsp90 protein binding
    (GO:0051879)
  • Identical protein binding
    (GO:0042802)
  • Integrin binding
    (GO:0005178)
  • Lung alveolus development
    (GO:0048286)
  • Lymph vessel development
    (GO:0001945)
  • Mesenchymal cell proliferation
    (GO:0010463)
  • Multicellular organism development
    (GO:0007275)
  • Negative regulation of apoptotic process
    (GO:0043066)
  • Negative regulation of gene expression
    (GO:0010629)
  • Negative regulation of neuron apoptotic process
    (GO:0043524)
  • Ovarian follicle development
    (GO:0001541)
  • Peptidyl-tyrosine autophosphorylation
    (GO:0038083)
  • Peptidyl-tyrosine phosphorylation
    (GO:0018108)
  • Positive regulation of angiogenesis
    (GO:0045766)
  • Positive regulation of blood vessel endothelial cell migration
    (GO:0043536)
  • Positive regulation of bmp signaling pathway
    (GO:0030513)
  • Positive regulation of cell migration
    (GO:0030335)
  • Positive regulation of cell migration involved in sprouting angiogenesis
    (GO:0090050)
  • Positive regulation of cell population proliferation
    (GO:0008284)
  • Positive regulation of endothelial cell chemotaxis by vegf-activated vascular endothelial growth factor receptor signaling pathway
    (GO:0038033)
  • Positive regulation of endothelial cell migration
    (GO:0010595)
  • Positive regulation of endothelial cell proliferation
    (GO:0001938)
  • Positive regulation of erk1 and erk2 cascade
    (GO:0070374)
  • Positive regulation of focal adhesion assembly
    (GO:0051894)
  • Positive regulation of kinase activity
    (GO:0033674)
  • Positive regulation of macroautophagy
    (GO:0016239)
  • Positive regulation of mapk cascade
    (GO:0043410)
  • Positive regulation of mesenchymal cell proliferation
    (GO:0002053)
  • Positive regulation of mitochondrial depolarization
    (GO:0051901)
  • Positive regulation of mitochondrial fission
    (GO:0090141)
  • Positive regulation of nitric-oxide synthase biosynthetic process
    (GO:0051770)
  • Positive regulation of phosphatidylinositol 3-kinase/protein kinase b signal transduction
    (GO:0051897)
  • Positive regulation of positive chemotaxis
    (GO:0050927)
  • Positive regulation of protein phosphorylation
    (GO:0001934)
  • Post-embryonic camera-type eye morphogenesis
    (GO:0048597)
  • Protein autophosphorylation
    (GO:0046777)
  • Protein binding
    (GO:0005515)
  • Protein tyrosine kinase activity
    (GO:0004713)
  • Regulation of bone development
    (GO:1903010)
  • Regulation of cell shape
    (GO:0008360)
  • Regulation of hematopoietic progenitor cell differentiation
    (GO:1901532)
  • Regulation of mapk cascade
    (GO:0043408)
  • Semaphorin-plexin signaling pathway
    (GO:0071526)
  • Stem cell proliferation
    (GO:0072089)
  • Surfactant homeostasis
    (GO:0043129)
  • Transmembrane receptor protein tyrosine kinase activity
    (GO:0004714)
  • Transmembrane receptor protein tyrosine kinase signaling pathway
    (GO:0007169)
  • Vascular endothelial growth factor binding
    (GO:0038085)
  • Vascular endothelial growth factor receptor-2 signaling pathway
    (GO:0036324)
  • Vascular endothelial growth factor receptor activity
    (GO:0005021)
  • Vascular endothelial growth factor receptor signaling pathway
    (GO:0048010)
  • Vascular endothelial growth factor signaling pathway
    (GO:0038084)
  • Vascular wound healing
    (GO:0061042)
  • Vasculogenesis
    (GO:0001570)

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 2.97
    Marker Score: 26037
  • Cell Name: type EC enteroendocrine cell (CL0000577)
    Fold Change: 2.27
    Marker Score: 2140
  • Cell Name: endothelial cell of sinusoid (CL0002262)
    Fold Change: 2.13
    Marker Score: 516
  • Cell Name: endocardial cell (CL0002350)
    Fold Change: 1.73
    Marker Score: 978
  • Cell Name: endothelial cell of uterus (CL0009095)
    Fold Change: 1.6
    Marker Score: 3205
  • Cell Name: alveolar capillary type 2 endothelial cell (CL4028003)
    Fold Change: 1.54
    Marker Score: 2228
  • Cell Name: mural cell (CL0008034)
    Fold Change: 1.47
    Marker Score: 169132
  • Cell Name: endothelial cell of pericentral hepatic sinusoid (CL0019022)
    Fold Change: 1.44
    Marker Score: 1539
  • Cell Name: endothelial tip cell (CL0000704)
    Fold Change: 1.39
    Marker Score: 324.5
  • Cell Name: Unknown (CL0002371)
    Fold Change: 1.36
    Marker Score: 1449
  • Cell Name: glomerular endothelial cell (CL0002188)
    Fold Change: 1.36
    Marker Score: 345
  • Cell Name: ovarian surface epithelial cell (CL2000064)
    Fold Change: 1.32
    Marker Score: 3591
  • Cell Name: peritubular capillary endothelial cell (CL1001033)
    Fold Change: 1.31
    Marker Score: 304
  • Cell Name: Mueller cell (CL0000636)
    Fold Change: 1.3
    Marker Score: 1796
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 1.24
    Marker Score: 12499
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 1.24
    Marker Score: 388
  • Cell Name: retinal blood vessel endothelial cell (CL0002585)
    Fold Change: 1.21
    Marker Score: 290
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 1.04
    Marker Score: 251795
  • Cell Name: capillary endothelial cell (CL0002144)
    Fold Change: 1.03
    Marker Score: 1103
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71813
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48038
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 0.99
    Marker Score: 626
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30407
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 0.98
    Marker Score: 875
  • Cell Name: vein endothelial cell (CL0002543)
    Fold Change: 0.97
    Marker Score: 872
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.95
    Marker Score: 14913
  • Cell Name: mucus secreting cell (CL0000319)
    Fold Change: 0.95
    Marker Score: 242
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2413
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.95
    Marker Score: 1793
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.94
    Marker Score: 5345
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2735
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: 0.9
    Marker Score: 1307
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5280
  • Cell Name: lung microvascular endothelial cell (CL2000016)
    Fold Change: 0.85
    Marker Score: 181
  • Cell Name: endothelial cell of lymphatic vessel (CL0002138)
    Fold Change: 0.85
    Marker Score: 529
  • Cell Name: endothelial cell of hepatic sinusoid (CL1000398)
    Fold Change: 0.84
    Marker Score: 184
  • Cell Name: prostate gland microvascular endothelial cell (CL2000059)
    Fold Change: 0.84
    Marker Score: 325.5
  • Cell Name: mesothelial cell of epicardium (CL0011019)
    Fold Change: 0.8
    Marker Score: 258
  • Cell Name: vasa recta ascending limb cell (CL1001131)
    Fold Change: 0.8
    Marker Score: 211
  • Cell Name: alveolar capillary type 1 endothelial cell (CL4028002)
    Fold Change: 0.8
    Marker Score: 2022
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.77
    Marker Score: 1253
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.77
    Marker Score: 704
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.76
    Marker Score: 580
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.75
    Marker Score: 389
  • Cell Name: endothelial cell of periportal hepatic sinusoid (CL0019021)
    Fold Change: 0.71
    Marker Score: 196
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.7
    Marker Score: 1420.5
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.69
    Marker Score: 176
  • Cell Name: glomerular capillary endothelial cell (CL1001005)
    Fold Change: 0.63
    Marker Score: 177
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.63
    Marker Score: 380
  • Cell Name: endothelial cell of artery (CL1000413)
    Fold Change: 0.6
    Marker Score: 247
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.58
    Marker Score: 345
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 0.57
    Marker Score: 964.5
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.56
    Marker Score: 444
  • Cell Name: blood vessel endothelial cell (CL0000071)
    Fold Change: 0.54
    Marker Score: 541
  • Cell Name: respiratory goblet cell (CL0002370)
    Fold Change: 0.54
    Marker Score: 155
  • Cell Name: lung goblet cell (CL1000143)
    Fold Change: 0.51
    Marker Score: 146
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.49
    Marker Score: 130
  • Cell Name: erythroid lineage cell (CL0000764)
    Fold Change: 0.47
    Marker Score: 235
  • Cell Name: mesothelial cell (CL0000077)
    Fold Change: 0.47
    Marker Score: 188
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: 0.47
    Marker Score: 310
  • Cell Name: club cell (CL0000158)
    Fold Change: 0.47
    Marker Score: 543
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 0.46
    Marker Score: 227
  • Cell Name: pulmonary artery endothelial cell (CL1001568)
    Fold Change: 0.46
    Marker Score: 393
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.45
    Marker Score: 216
  • Cell Name: epicardial adipocyte (CL1000309)
    Fold Change: 0.44
    Marker Score: 213
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 0.42
    Marker Score: 1821
  • Cell Name: dermis microvascular lymphatic vessel endothelial cell (CL2000041)
    Fold Change: 0.42
    Marker Score: 136
  • Cell Name: photoreceptor cell (CL0000210)
    Fold Change: 0.42
    Marker Score: 314
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: 0.41
    Marker Score: 180
  • Cell Name: bronchial goblet cell (CL1000312)
    Fold Change: 0.41
    Marker Score: 203
  • Cell Name: corneal endothelial cell (CL0000132)
    Fold Change: 0.41
    Marker Score: 236
  • Cell Name: uterine smooth muscle cell (CL0002601)
    Fold Change: 0.4
    Marker Score: 524
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: 0.38
    Marker Score: 434
  • Cell Name: malignant cell (CL0001064)
    Fold Change: 0.35
    Marker Score: 4648
  • Cell Name: respiratory epithelial cell (CL0002368)
    Fold Change: 0.33
    Marker Score: 181
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: 0.33
    Marker Score: 153
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.32
    Marker Score: 142
  • Cell Name: kidney loop of Henle epithelial cell (CL1000909)
    Fold Change: 0.3
    Marker Score: 191
  • Cell Name: neural crest cell (CL0011012)
    Fold Change: 0.29
    Marker Score: 311
  • Cell Name: cardiac mesenchymal cell (CL0000569)
    Fold Change: 0.28
    Marker Score: 69
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: 0.28
    Marker Score: 423.5
  • Cell Name: migratory enteric neural crest cell (CL0002607)
    Fold Change: 0.27
    Marker Score: 257
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.26
    Marker Score: 174.5
  • Cell Name: choroid plexus epithelial cell (CL0000706)
    Fold Change: 0.26
    Marker Score: 242
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: 0.26
    Marker Score: 89
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: 0.25
    Marker Score: 244
  • Cell Name: smooth muscle cell of prostate (CL1000487)
    Fold Change: 0.24
    Marker Score: 61
  • Cell Name: renal intercalated cell (CL0005010)
    Fold Change: 0.23
    Marker Score: 121
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: 0.22
    Marker Score: 75
  • Cell Name: Unknown (CL0000003)
    Fold Change: 0.21
    Marker Score: 649
  • Cell Name: group 3 innate lymphoid cell (CL0001071)
    Fold Change: 0.2
    Marker Score: 85
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: 0.2
    Marker Score: 52
  • Cell Name: retinal pigment epithelial cell (CL0002586)
    Fold Change: 0.2
    Marker Score: 58
  • Cell Name: fibroblast (CL0000057)
    Fold Change: 0.2
    Marker Score: 189
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: 0.19
    Marker Score: 108
  • Cell Name: neural cell (CL0002319)
    Fold Change: 0.19
    Marker Score: 93
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: 0.19
    Marker Score: 184
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: 0.19
    Marker Score: 94
  • Cell Name: podocyte (CL0000653)
    Fold Change: 0.18
    Marker Score: 68
  • Cell Name: kidney collecting duct cell (CL1001225)
    Fold Change: 0.18
    Marker Score: 36

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Other Information

**Key characteristics:** - KDR is a type of cell surface receptor that is expressed on endothelial cells, immune cells, and some cancer cells. - It is a kinase that is activated by various growth factors and cytokines. - KDR is a key regulator of vascular endothelial growth factor (VEGF) signaling. **Pathways and functions:** - KDR is a key regulator of VEGF signaling. - VEGF is a protein that is produced by endothelial cells and promotes the growth and survival of endothelial cells. - When VEGF binds to KDR, it triggers a signaling cascade that leads to the activation of downstream signaling pathways. - These pathways include the PI3K/AKT/mTOR pathway, the MAPK pathway, and the JAK/STAT pathway. - Activation of these pathways leads to the proliferation, migration, and survival of endothelial cells. **Clinical significance:** - Mutations in the KDR gene have been linked to several human diseases, including cancer, cardiovascular disease, and diabetes. - In cancer, KDR mutations can lead to the survival of tumor cells and the growth of tumors. - Targeting KDR signaling has emerged as a promising therapeutic strategy for cancer. **Additional notes:** - KDR is also involved in the regulation of cell migration, angiogenesis, and inflammation. - It is a key regulator of vascular development and remodeling. - Mutations in the KDR gene have been linked to the development of diabetic retinopathy, a leading cause of blindness in people over 65.

Genular Protein ID: 867410034

Symbol: VGFR2_HUMAN

Name: Fetal liver kinase 1

UniProtKB Accession Codes:

P35968 A2RRS0 B5A925 C5IFA0 O60723 Q14178

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Antibodypedia 1 BMRB 1 BRENDA 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 4 CORUM 1 CPTAC 1 CTD 1 CarbonylDB 1 ChEBI 7 ChEMBL 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 41 DrugCentral 1 EC 1 EMBL 10 EPD 1 Ensembl 1 EvolutionaryTrace 1 GO 87 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 GuidetoPHARMACOLOGY 1 HGNC 2 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 16 KEGG 1 MANE-Select 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 2 OrthoDB 1 PANTHER 2 PDB 68 PDBsum 54 PIR 1 PIRSF 1 PRINTS 2 PRO 1 PROSITE 5 PROSITE-ProRule 3 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 6 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 3 RNAct 1 Reactome 6 RefSeq 1 Rhea 3 SAM 1 SIGNOR 1 SMART 3 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 TreeFam 1 UCSC 1 UniProtKB 3 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 18593464

Title: Novel splice variants derived from the receptor tyrosine kinase superfamily are potential therapeutics for rheumatoid arthritis.

PubMed ID: 18593464

DOI: 10.1186/ar2447

PubMed ID: 19668192

Title: Alternatively spliced vascular endothelial growth factor receptor-2 is an essential endogenous inhibitor of lymphatic vessel growth.

PubMed ID: 19668192

DOI: 10.1038/nm.2018

PubMed ID: 15815621

Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.

PubMed ID: 15815621

DOI: 10.1038/nature03466

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 1656371

Title: Identification of a new endothelial cell growth factor receptor tyrosine kinase.

PubMed ID: 1656371

PubMed ID: 7559454

Title: Cloning and functional analysis of the promoter for KDR/flk-1, a receptor for vascular endothelial growth factor.

PubMed ID: 7559454

DOI: 10.1074/jbc.270.39.23111

PubMed ID: 1417831

Title: Identification of the KDR tyrosine kinase as a receptor for vascular endothelial cell growth factor.

PubMed ID: 1417831

DOI: 10.1016/0006-291x(92)90483-2

PubMed ID: 7929439

Title: Different signal transduction properties of KDR and Flt1, two receptors for vascular endothelial growth factor.

PubMed ID: 7929439

DOI: 10.1016/s0021-9258(18)47116-5

PubMed ID: 9160888

Title: The 230 kDa mature form of KDR/Flk-1 (VEGF receptor-2) activates the PLC-gamma pathway and partially induces mitotic signals in NIH3T3 fibroblasts.

PubMed ID: 9160888

DOI: 10.1038/sj.onc.1201047

PubMed ID: 9837777

Title: VEGF-A induces expression of eNOS and iNOS in endothelial cells via VEGF receptor-2 (KDR).

PubMed ID: 9837777

DOI: 10.1006/bbrc.1998.9719

PubMed ID: 9804796

Title: Vascular endothelial growth factor regulates endothelial cell survival through the phosphatidylinositol 3'-kinase/Akt signal transduction pathway. Requirement for Flk-1/KDR activation.

PubMed ID: 9804796

DOI: 10.1074/jbc.273.46.30336

PubMed ID: 10600473

Title: A novel function of VEGF receptor-2 (KDR): rapid release of nitric oxide in response to VEGF-A stimulation in endothelial cells.

PubMed ID: 10600473

DOI: 10.1006/bbrc.1999.1729

PubMed ID: 10037737

Title: Vascular endothelial growth factor receptor KDR tyrosine kinase activity is increased by autophosphorylation of two activation loop tyrosine residues.

PubMed ID: 10037737

DOI: 10.1074/jbc.274.10.6453

PubMed ID: 10102632

Title: Autophosphorylation of KDR in the kinase domain is required for maximal VEGF-stimulated kinase activity and receptor internalization.

PubMed ID: 10102632

DOI: 10.1038/sj.onc.1202478

PubMed ID: 10590123

Title: Identification of specific molecular structures of human immunodeficiency virus type 1 Tat relevant for its biological effects on vascular endothelial cells.

PubMed ID: 10590123

DOI: 10.1128/jvi.74.1.344-353.2000

PubMed ID: 11387210

Title: A single autophosphorylation site on KDR/Flk-1 is essential for VEGF-A-dependent activation of PLC-gamma and DNA synthesis in vascular endothelial cells.

PubMed ID: 11387210

DOI: 10.1093/emboj/20.11.2768

PubMed ID: 12649282

Title: Vascular endothelial growth factor-dependent down-regulation of Flk-1/KDR involves Cbl-mediated ubiquitination. Consequences on nitric oxide production from endothelial cells.

PubMed ID: 12649282

DOI: 10.1074/jbc.m301410200

PubMed ID: 12881528

Title: Ligand-induced vascular endothelial growth factor receptor-3 (VEGFR-3) heterodimerization with VEGFR-2 in primary lymphatic endothelial cells regulates tyrosine phosphorylation sites.

PubMed ID: 12881528

DOI: 10.1074/jbc.m304499200

PubMed ID: 15026417

Title: The adaptor protein shb binds to tyrosine 1175 in vascular endothelial growth factor (VEGF) receptor-2 and regulates VEGF-dependent cellular migration.

PubMed ID: 15026417

DOI: 10.1074/jbc.m312729200

PubMed ID: 14991896

Title: Phosphorylated KDR is expressed in the neoplastic and stromal elements of human renal tumours and shuttles from cell membrane to nucleus.

PubMed ID: 14991896

DOI: 10.1002/path.1520

PubMed ID: 15215251

Title: Vascular endothelial growth factor (VEGF)-D and VEGF-A differentially regulate KDR-mediated signaling and biological function in vascular endothelial cells.

PubMed ID: 15215251

DOI: 10.1074/jbc.m401538200

PubMed ID: 15962004

Title: VEGF receptor-2 Y951 signaling and a role for the adapter molecule TSAd in tumor angiogenesis.

PubMed ID: 15962004

DOI: 10.1038/sj.emboj.7600709

PubMed ID: 16966330

Title: Phosphorylation of Tyr1214 within VEGFR-2 triggers the recruitment of Nck and activation of Fyn leading to SAPK2/p38 activation and endothelial cell migration in response to VEGF.

PubMed ID: 16966330

DOI: 10.1074/jbc.m603928200

PubMed ID: 17004325

Title: Intrinsic tyrosine kinase activity is required for vascular endothelial growth factor receptor 2 ubiquitination, sorting and degradation in endothelial cells.

PubMed ID: 17004325

DOI: 10.1111/j.1600-0854.2006.00462.x

PubMed ID: 17303569

Title: Phosphorylation of tyrosine 801 of vascular endothelial growth factor receptor-2 is necessary for Akt-dependent endothelial nitric-oxide synthase activation and nitric oxide release from endothelial cells.

PubMed ID: 17303569

DOI: 10.1074/jbc.m609048200

PubMed ID: 19033661

Title: AIP1 functions as an endogenous inhibitor of VEGFR2-mediated signaling and inflammatory angiogenesis in mice.

PubMed ID: 19033661

DOI: 10.1172/jci36168

PubMed ID: 19136612

Title: Transcriptional profiling reveals a critical role for tyrosine phosphatase VE-PTP in regulation of VEGFR2 activity and endothelial cell morphogenesis.

PubMed ID: 19136612

DOI: 10.1096/fj.08-123810

PubMed ID: 18936167

Title: New role for the protein tyrosine phosphatase DEP-1 in Akt activation and endothelial cell survival.

PubMed ID: 18936167

DOI: 10.1128/mcb.01374-08

PubMed ID: 19834490

Title: VEGF-dependent tumor angiogenesis requires inverse and reciprocal regulation of VEGFR1 and VEGFR2.

PubMed ID: 19834490

DOI: 10.1038/cdd.2009.152

PubMed ID: 20179233

Title: Neuroblastoma progression correlates with downregulation of the lymphangiogenesis inhibitor sVEGFR-2.

PubMed ID: 20179233

DOI: 10.1158/1078-0432.ccr-09-1936

PubMed ID: 20224550

Title: VEGF receptor 2/-3 heterodimers detected in situ by proximity ligation on angiogenic sprouts.

PubMed ID: 20224550

DOI: 10.1038/emboj.2010.30

PubMed ID: 21539813

Title: The VEGFR2 receptor tyrosine kinase undergoes constitutive endosome-to-plasma membrane recycling.

PubMed ID: 21539813

DOI: 10.1016/j.bbrc.2011.04.093

PubMed ID: 20705758

Title: Blood vessel endothelial VEGFR-2 delays lymphangiogenesis: an endogenous trapping mechanism links lymph- and angiogenesis.

PubMed ID: 20705758

DOI: 10.1182/blood-2010-02-267427

PubMed ID: 17002866

Title: Differential roles of vascular endothelial growth factor receptor-1 and receptor-2 in angiogenesis.

PubMed ID: 17002866

DOI: 10.5483/bmbrep.2006.39.5.469

PubMed ID: 17658244

Title: Vascular endothelial growth factor receptor-2: structure, function, intracellular signalling and therapeutic inhibition.

PubMed ID: 17658244

DOI: 10.1016/j.cellsig.2007.05.013

PubMed ID: 18680722

Title: VEGF receptor protein-tyrosine kinases: structure and regulation.

PubMed ID: 18680722

DOI: 10.1016/j.bbrc.2008.07.121

PubMed ID: 19230644

Title: VEGFs and receptors involved in angiogenesis versus lymphangiogenesis.

PubMed ID: 19230644

DOI: 10.1016/j.ceb.2008.12.012

PubMed ID: 19761875

Title: Structure-function analysis of VEGF receptor activation and the role of coreceptors in angiogenic signaling.

PubMed ID: 19761875

DOI: 10.1016/j.bbapap.2009.09.002

PubMed ID: 20462514

Title: Vascular endothelial growth factor receptor-2 in breast cancer.

PubMed ID: 20462514

DOI: 10.1016/j.bbcan.2010.04.004

PubMed ID: 21779435

Title: Tyrosine kinase receptor Flt/VEGFR family: its characterization related to angiogenesis and cancer.

PubMed ID: 21779435

DOI: 10.1177/1947601910392987

PubMed ID: 21711246

Title: Signal transduction by vascular endothelial growth factor receptors.

PubMed ID: 21711246

DOI: 10.1042/bj20110301

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 21893193

Title: Programmed cell death 6 (PDCD6) inhibits angiogenesis through PI3K/mTOR/p70S6K pathway by interacting of VEGFR-2.

PubMed ID: 21893193

DOI: 10.1016/j.cellsig.2011.08.013

PubMed ID: 23199280

Title: VEGFR2 functions as an H(2)S-targeting receptor protein kinase with its novel Cys1045-Cys1024 disulfide bond serving as a specific molecular switch for hydrogen sulfide actions in vascular endothelial cells.

PubMed ID: 23199280

DOI: 10.1089/ars.2012.4565

PubMed ID: 23529610

Title: Vascular endothelial cell growth-activated XBP1 splicing in endothelial cells is crucial for angiogenesis.

PubMed ID: 23529610

DOI: 10.1161/circulationaha.112.001337

PubMed ID: 23792958

Title: Identification of PDCL3 as a novel chaperone protein involved in the generation of functional VEGF receptor 2.

PubMed ID: 23792958

DOI: 10.1074/jbc.m113.473173

PubMed ID: 25187647

Title: Structural basis for activation of trimeric Gi proteins by multiple growth factor receptors via GIV/Girdin.

PubMed ID: 25187647

DOI: 10.1091/mbc.e14-05-0978

PubMed ID: 26059764

Title: Hypoxia-induced expression of phosducin-like 3 regulates expression of VEGFR-2 and promotes angiogenesis.

PubMed ID: 26059764

DOI: 10.1007/s10456-015-9468-3

PubMed ID: 25825981

Title: EMMPRIN/CD147 is a novel coreceptor of VEGFR-2 mediating its activation by VEGF.

PubMed ID: 25825981

DOI: 10.18632/oncotarget.2870

PubMed ID: 35027734

Title: Cysteine oxidation of copper transporter CTR1 drives VEGFR2 signalling and angiogenesis.

PubMed ID: 35027734

DOI: 10.1038/s41556-021-00822-7

PubMed ID: 10368301

Title: Crystal structure of the kinase domain of human vascular endothelial growth factor receptor 2: a key enzyme in angiogenesis.

PubMed ID: 10368301

DOI: 10.1016/s0969-2126(99)80042-2

PubMed ID: 15837294

Title: Novel 4-amino-furo[2,3-d]pyrimidines as Tie-2 and VEGFR2 dual inhibitors.

PubMed ID: 15837294

DOI: 10.1016/j.bmcl.2005.03.034

PubMed ID: 17253678

Title: Evolution of a highly selective and potent 2-(pyridin-2-yl)-1,3,5-triazine Tie-2 kinase inhibitor.

PubMed ID: 17253678

DOI: 10.1021/jm061107l

PubMed ID: 18529047

Title: Design, synthesis, and biological evaluation of novel 3-aryl-4-(1H-indole-3yl)-1,5-dihydro-2H-pyrrole-2-ones as vascular endothelial growth factor receptor (VEGF-R) inhibitors.

PubMed ID: 18529047

DOI: 10.1021/jm8001185

PubMed ID: 20080685

Title: Direct contacts between extracellular membrane-proximal domains are required for VEGF receptor activation and cell signaling.

PubMed ID: 20080685

DOI: 10.1073/pnas.0914052107

PubMed ID: 20145116

Title: Structural determinants of growth factor binding and specificity by VEGF receptor 2.

PubMed ID: 20145116

DOI: 10.1073/pnas.0914318107

PubMed ID: 21827946

Title: The structural basis for the function of two anti-VEGF receptor 2 antibodies.

PubMed ID: 21827946

DOI: 10.1016/j.str.2011.01.019

PubMed ID: 11807987

Title: Somatic mutation of vascular endothelial growth factor receptors in juvenile hemangioma.

PubMed ID: 11807987

DOI: 10.1002/gcc.10028

PubMed ID: 16959974

Title: The consensus coding sequences of human breast and colorectal cancers.

PubMed ID: 16959974

DOI: 10.1126/science.1133427

PubMed ID: 17344846

Title: Patterns of somatic mutation in human cancer genomes.

PubMed ID: 17344846

DOI: 10.1038/nature05610

PubMed ID: 18931684

Title: Suppressed NFAT-dependent VEGFR1 expression and constitutive VEGFR2 signaling in infantile hemangioma.

PubMed ID: 18931684

DOI: 10.1038/nm.1877

Sequence Information:

  • Length: 1356
  • Mass: 151527
  • Checksum: 59E7C44B05CFEBB3
  • Sequence:
    • MQSKVLLAVA LWLCVETRAA SVGLPSVSLD LPRLSIQKDI LTIKANTTLQ ITCRGQRDLD 
WLWPNNQSGS EQRVEVTECS DGLFCKTLTI PKVIGNDTGA YKCFYRETDL ASVIYVYVQD 
YRSPFIASVS DQHGVVYITE NKNKTVVIPC LGSISNLNVS LCARYPEKRF VPDGNRISWD 
SKKGFTIPSY MISYAGMVFC EAKINDESYQ SIMYIVVVVG YRIYDVVLSP SHGIELSVGE 
KLVLNCTART ELNVGIDFNW EYPSSKHQHK KLVNRDLKTQ SGSEMKKFLS TLTIDGVTRS 
DQGLYTCAAS SGLMTKKNST FVRVHEKPFV AFGSGMESLV EATVGERVRI PAKYLGYPPP 
EIKWYKNGIP LESNHTIKAG HVLTIMEVSE RDTGNYTVIL TNPISKEKQS HVVSLVVYVP 
PQIGEKSLIS PVDSYQYGTT QTLTCTVYAI PPPHHIHWYW QLEEECANEP SQAVSVTNPY 
PCEEWRSVED FQGGNKIEVN KNQFALIEGK NKTVSTLVIQ AANVSALYKC EAVNKVGRGE 
RVISFHVTRG PEITLQPDMQ PTEQESVSLW CTADRSTFEN LTWYKLGPQP LPIHVGELPT 
PVCKNLDTLW KLNATMFSNS TNDILIMELK NASLQDQGDY VCLAQDRKTK KRHCVVRQLT 
VLERVAPTIT GNLENQTTSI GESIEVSCTA SGNPPPQIMW FKDNETLVED SGIVLKDGNR 
NLTIRRVRKE DEGLYTCQAC SVLGCAKVEA FFIIEGAQEK TNLEIIILVG TAVIAMFFWL 
LLVIILRTVK RANGGELKTG YLSIVMDPDE LPLDEHCERL PYDASKWEFP RDRLKLGKPL 
GRGAFGQVIE ADAFGIDKTA TCRTVAVKML KEGATHSEHR ALMSELKILI HIGHHLNVVN 
LLGACTKPGG PLMVIVEFCK FGNLSTYLRS KRNEFVPYKT KGARFRQGKD YVGAIPVDLK 
RRLDSITSSQ SSASSGFVEE KSLSDVEEEE APEDLYKDFL TLEHLICYSF QVAKGMEFLA 
SRKCIHRDLA ARNILLSEKN VVKICDFGLA RDIYKDPDYV RKGDARLPLK WMAPETIFDR 
VYTIQSDVWS FGVLLWEIFS LGASPYPGVK IDEEFCRRLK EGTRMRAPDY TTPEMYQTML 
DCWHGEPSQR PTFSELVEHL GNLLQANAQQ DGKDYIVLPI SETLSMEEDS GLSLPTSPVS 
CMEEEEVCDP KFHYDNTAGI SQYLQNSKRK SRPVSVKTFE DIPLEEPEVK VIPDDNQTDS 
GMVLASEELK TLEDRTKLSP SFGGMVPSKS RESVASEGSN QTSGYQSGYH SDDTDTTVYS 
SEEAELLKLI EIGVQTGSTA QILQPDSGTT LSSPPV

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.