Details for: KDR

Gene ID: 3791

Symbol: KDR

Ensembl ID: ENSG00000128052

Description: kinase insert domain receptor

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 28.1832
    Cell Significance Index: -11.6100
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 23.9750
    Cell Significance Index: -9.7400
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: 15.2173
    Cell Significance Index: 91.9400
  • Cell Name: glomerular capillary endothelial cell (CL1001005)
    Fold Change: 11.6636
    Cell Significance Index: 43.4700
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 10.0446
    Cell Significance Index: -9.5900
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 7.0182
    Cell Significance Index: -15.3600
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 6.0055
    Cell Significance Index: 312.8200
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 2.8853
    Cell Significance Index: 61.6800
  • Cell Name: endocardial cell (CL0002350)
    Fold Change: 2.4585
    Cell Significance Index: 14.5200
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 1.9472
    Cell Significance Index: 31.2400
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 1.7782
    Cell Significance Index: 25.5800
  • Cell Name: ovarian surface epithelial cell (CL2000064)
    Fold Change: 1.5441
    Cell Significance Index: 7.5100
  • Cell Name: endothelial stalk cell (CL0002671)
    Fold Change: 1.5421
    Cell Significance Index: 17.2800
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 1.5184
    Cell Significance Index: 17.2500
  • Cell Name: endothelial cell of sinusoid (CL0002262)
    Fold Change: 1.4269
    Cell Significance Index: 10.4600
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 1.2629
    Cell Significance Index: 13.0800
  • Cell Name: prostate gland microvascular endothelial cell (CL2000059)
    Fold Change: 1.1306
    Cell Significance Index: 8.1200
  • Cell Name: endothelial cell of uterus (CL0009095)
    Fold Change: 0.9071
    Cell Significance Index: 5.6800
  • Cell Name: endothelial cell of pericentral hepatic sinusoid (CL0019022)
    Fold Change: 0.8658
    Cell Significance Index: 6.8400
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 0.6714
    Cell Significance Index: 11.8700
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.5132
    Cell Significance Index: 28.8000
  • Cell Name: pulmonary capillary endothelial cell (CL4028001)
    Fold Change: 0.4305
    Cell Significance Index: 5.9000
  • Cell Name: endothelial cell of periportal hepatic sinusoid (CL0019021)
    Fold Change: 0.4082
    Cell Significance Index: 1.4200
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 0.3186
    Cell Significance Index: 4.9300
  • Cell Name: Mueller cell (CL0000636)
    Fold Change: 0.1495
    Cell Significance Index: 1.1500
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: 0.0548
    Cell Significance Index: 34.2400
  • Cell Name: gut endothelial cell (CL0000131)
    Fold Change: 0.0320
    Cell Significance Index: 0.2200
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: 0.0283
    Cell Significance Index: 0.3100
  • Cell Name: photoreceptor cell (CL0000210)
    Fold Change: 0.0206
    Cell Significance Index: 0.2900
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.0119
    Cell Significance Index: 2.3600
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.0032
    Cell Significance Index: 2.2200
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0019
    Cell Significance Index: -2.8600
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0045
    Cell Significance Index: -8.5300
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0052
    Cell Significance Index: -3.8200
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0065
    Cell Significance Index: -12.0000
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0075
    Cell Significance Index: -4.2200
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0096
    Cell Significance Index: -13.0000
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0148
    Cell Significance Index: -11.2400
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0154
    Cell Significance Index: -11.2600
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0161
    Cell Significance Index: -10.2400
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0208
    Cell Significance Index: -11.3700
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0216
    Cell Significance Index: -9.8000
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0217
    Cell Significance Index: -4.5700
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.0224
    Cell Significance Index: -0.6000
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0245
    Cell Significance Index: -4.1800
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0308
    Cell Significance Index: -11.0600
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0354
    Cell Significance Index: -6.3900
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0392
    Cell Significance Index: -11.2700
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0422
    Cell Significance Index: -5.8000
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0560
    Cell Significance Index: -11.2300
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0612
    Cell Significance Index: -7.8500
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0640
    Cell Significance Index: -7.8800
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.0649
    Cell Significance Index: -2.8200
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0712
    Cell Significance Index: -10.3500
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.0712
    Cell Significance Index: -8.1300
  • Cell Name: endothelial tip cell (CL0000704)
    Fold Change: -0.0814
    Cell Significance Index: -0.3500
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0852
    Cell Significance Index: -11.0100
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0936
    Cell Significance Index: -9.5600
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0988
    Cell Significance Index: -11.3200
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1101
    Cell Significance Index: -11.4600
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.1223
    Cell Significance Index: -5.7000
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.1230
    Cell Significance Index: -2.9800
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.1247
    Cell Significance Index: -3.2800
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: -0.1318
    Cell Significance Index: -1.6200
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.1351
    Cell Significance Index: -10.3700
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.1439
    Cell Significance Index: -9.0700
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.1444
    Cell Significance Index: -11.4400
  • Cell Name: cone retinal bipolar cell (CL0000752)
    Fold Change: -0.1453
    Cell Significance Index: -1.1200
  • Cell Name: lung microvascular endothelial cell (CL2000016)
    Fold Change: -0.1536
    Cell Significance Index: -1.3000
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.1540
    Cell Significance Index: -11.4800
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.1650
    Cell Significance Index: -10.1400
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: -0.1682
    Cell Significance Index: -2.3100
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.1739
    Cell Significance Index: -11.6900
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.1917
    Cell Significance Index: -9.0100
  • Cell Name: respiratory goblet cell (CL0002370)
    Fold Change: -0.2036
    Cell Significance Index: -2.1000
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.2072
    Cell Significance Index: -10.8800
  • Cell Name: endothelial cell of hepatic sinusoid (CL1000398)
    Fold Change: -0.2188
    Cell Significance Index: -2.0800
  • Cell Name: blood vessel endothelial cell (CL0000071)
    Fold Change: -0.2379
    Cell Significance Index: -2.5800
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.2550
    Cell Significance Index: -12.8900
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.2619
    Cell Significance Index: -11.8700
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.2672
    Cell Significance Index: -11.8200
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.2737
    Cell Significance Index: -14.2200
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.2809
    Cell Significance Index: -10.3100
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.3111
    Cell Significance Index: -11.7800
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.3248
    Cell Significance Index: -11.2900
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.3405
    Cell Significance Index: -11.9300
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: -0.3507
    Cell Significance Index: -7.1400
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.3624
    Cell Significance Index: -9.7000
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.3679
    Cell Significance Index: -12.0500
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.3714
    Cell Significance Index: -11.8300
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.3740
    Cell Significance Index: -10.7200
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.3791
    Cell Significance Index: -8.1900
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.3830
    Cell Significance Index: -11.2800
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.3876
    Cell Significance Index: -10.3500
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: -0.3911
    Cell Significance Index: -12.3700
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.4072
    Cell Significance Index: -11.6200
  • Cell Name: corneal endothelial cell (CL0000132)
    Fold Change: -0.4102
    Cell Significance Index: -6.2400
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.4116
    Cell Significance Index: -10.5800
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: -0.4187
    Cell Significance Index: -10.4400
  • Cell Name: capillary endothelial cell (CL0002144)
    Fold Change: -0.4208
    Cell Significance Index: -4.7800

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** The KDR gene is a single-pass transmembrane receptor tyrosine kinase that belongs to the vascular endothelial growth factor (VEGF) receptor family. It is composed of 10 exons and encodes a 145-kDa protein. The KDR gene is highly expressed in endothelial cells, which are the primary cells involved in angiogenesis. The gene is also expressed in other cell types, including mesenchymal cells, smooth muscle cells, and pericytes. **Pathways and Functions:** The KDR gene is a key player in the VEGF signaling pathway, which is a critical regulator of angiogenesis. When VEGF binds to KDR, it triggers a series of downstream signaling events that lead to the activation of various cellular processes, including: 1. Endothelial cell proliferation and migration 2. Endothelial cell differentiation 3. Angiogenesis 4. Vascular endothelial cell chemotaxis 5. Cell migration involved in sprouting angiogenesis The KDR gene also interacts with other signaling pathways, including the PI3K/AKT, MAPK, and ERK cascades, which regulate cell survival, differentiation, and proliferation. **Clinical Significance:** The KDR gene has been implicated in various diseases, including: 1. Cancer: KDR is overexpressed in many types of cancer, including breast, lung, and colon cancer, and is associated with poor prognosis. 2. Cardiovascular disease: KDR is involved in the development of atherosclerosis and cardiac hypertrophy. 3. Wound healing: KDR plays a critical role in the regulation of angiogenesis during wound healing. 4. Neurological disorders: KDR is involved in the regulation of angiogenesis in the central nervous system and is implicated in the pathogenesis of neurodegenerative diseases, such as Alzheimer's disease and Parkinson's disease. The KDR gene has also been targeted for therapeutic intervention in various diseases, including cancer and cardiovascular disease. Small molecule inhibitors of KDR, such as bevacizumab, have been shown to be effective in treating certain types of cancer. **Signaling by KDR:** The KDR gene signals through a variety of mechanisms, including: 1. Phosphorylation of tyrosine residues on the KDR protein 2. Activation of downstream signaling cascades, including the PI3K/AKT, MAPK, and ERK cascades 3. Regulation of cellular processes, including endothelial cell proliferation, migration, and differentiation Overall, the KDR gene is a critical regulator of angiogenesis and vascular development, and its dysregulation has been implicated in various diseases. Further research is needed to fully understand the mechanisms by which KDR regulates angiogenesis and to develop effective therapeutic strategies for the treatment of diseases associated with KDR dysfunction.

Genular Protein ID: 867410034

Symbol: VGFR2_HUMAN

Name: Fetal liver kinase 1

UniProtKB Accession Codes:

P35968 A2RRS0 B5A925 C5IFA0 O60723 Q14178

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Antibodypedia 1 BMRB 1 BRENDA 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 4 CORUM 1 CPTAC 1 CTD 1 CarbonylDB 1 ChEBI 7 ChEMBL 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 42 DrugCentral 1 EC 1 EMBL 10 Ensembl 1 EvolutionaryTrace 1 GO 85 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 GuidetoPHARMACOLOGY 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 17 KEGG 1 MANE-Select 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PDB 54 PDBsum 54 PIR 1 PIRSF 1 PRINTS 2 PRO 1 PROSITE 5 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 8 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 3 RNAct 1 Reactome 6 RefSeq 1 Rhea 3 SIGNOR 1 SMART 3 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 TreeFam 1 UCSC 1 UniProtKB 2 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 18593464

Title: Novel splice variants derived from the receptor tyrosine kinase superfamily are potential therapeutics for rheumatoid arthritis.

PubMed ID: 18593464

DOI: 10.1186/ar2447

PubMed ID: 19668192

Title: Alternatively spliced vascular endothelial growth factor receptor-2 is an essential endogenous inhibitor of lymphatic vessel growth.

PubMed ID: 19668192

DOI: 10.1038/nm.2018

PubMed ID: 15815621

Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.

PubMed ID: 15815621

DOI: 10.1038/nature03466

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 1656371

Title: Identification of a new endothelial cell growth factor receptor tyrosine kinase.

PubMed ID: 1656371

PubMed ID: 7559454

Title: Cloning and functional analysis of the promoter for KDR/flk-1, a receptor for vascular endothelial growth factor.

PubMed ID: 7559454

DOI: 10.1074/jbc.270.39.23111

PubMed ID: 1417831

Title: Identification of the KDR tyrosine kinase as a receptor for vascular endothelial cell growth factor.

PubMed ID: 1417831

DOI: 10.1016/0006-291x(92)90483-2

PubMed ID: 7929439

Title: Different signal transduction properties of KDR and Flt1, two receptors for vascular endothelial growth factor.

PubMed ID: 7929439

DOI: 10.1016/s0021-9258(18)47116-5

PubMed ID: 9160888

Title: The 230 kDa mature form of KDR/Flk-1 (VEGF receptor-2) activates the PLC-gamma pathway and partially induces mitotic signals in NIH3T3 fibroblasts.

PubMed ID: 9160888

DOI: 10.1038/sj.onc.1201047

PubMed ID: 9837777

Title: VEGF-A induces expression of eNOS and iNOS in endothelial cells via VEGF receptor-2 (KDR).

PubMed ID: 9837777

DOI: 10.1006/bbrc.1998.9719

PubMed ID: 9804796

Title: Vascular endothelial growth factor regulates endothelial cell survival through the phosphatidylinositol 3'-kinase/Akt signal transduction pathway. Requirement for Flk-1/KDR activation.

PubMed ID: 9804796

DOI: 10.1074/jbc.273.46.30336

PubMed ID: 10600473

Title: A novel function of VEGF receptor-2 (KDR): rapid release of nitric oxide in response to VEGF-A stimulation in endothelial cells.

PubMed ID: 10600473

DOI: 10.1006/bbrc.1999.1729

PubMed ID: 10037737

Title: Vascular endothelial growth factor receptor KDR tyrosine kinase activity is increased by autophosphorylation of two activation loop tyrosine residues.

PubMed ID: 10037737

DOI: 10.1074/jbc.274.10.6453

PubMed ID: 10102632

Title: Autophosphorylation of KDR in the kinase domain is required for maximal VEGF-stimulated kinase activity and receptor internalization.

PubMed ID: 10102632

DOI: 10.1038/sj.onc.1202478

PubMed ID: 10590123

Title: Identification of specific molecular structures of human immunodeficiency virus type 1 Tat relevant for its biological effects on vascular endothelial cells.

PubMed ID: 10590123

DOI: 10.1128/jvi.74.1.344-353.2000

PubMed ID: 11387210

Title: A single autophosphorylation site on KDR/Flk-1 is essential for VEGF-A-dependent activation of PLC-gamma and DNA synthesis in vascular endothelial cells.

PubMed ID: 11387210

DOI: 10.1093/emboj/20.11.2768

PubMed ID: 12649282

Title: Vascular endothelial growth factor-dependent down-regulation of Flk-1/KDR involves Cbl-mediated ubiquitination. Consequences on nitric oxide production from endothelial cells.

PubMed ID: 12649282

DOI: 10.1074/jbc.m301410200

PubMed ID: 12881528

Title: Ligand-induced vascular endothelial growth factor receptor-3 (VEGFR-3) heterodimerization with VEGFR-2 in primary lymphatic endothelial cells regulates tyrosine phosphorylation sites.

PubMed ID: 12881528

DOI: 10.1074/jbc.m304499200

PubMed ID: 15026417

Title: The adaptor protein shb binds to tyrosine 1175 in vascular endothelial growth factor (VEGF) receptor-2 and regulates VEGF-dependent cellular migration.

PubMed ID: 15026417

DOI: 10.1074/jbc.m312729200

PubMed ID: 14991896

Title: Phosphorylated KDR is expressed in the neoplastic and stromal elements of human renal tumours and shuttles from cell membrane to nucleus.

PubMed ID: 14991896

DOI: 10.1002/path.1520

PubMed ID: 15215251

Title: Vascular endothelial growth factor (VEGF)-D and VEGF-A differentially regulate KDR-mediated signaling and biological function in vascular endothelial cells.

PubMed ID: 15215251

DOI: 10.1074/jbc.m401538200

PubMed ID: 15962004

Title: VEGF receptor-2 Y951 signaling and a role for the adapter molecule TSAd in tumor angiogenesis.

PubMed ID: 15962004

DOI: 10.1038/sj.emboj.7600709

PubMed ID: 16966330

Title: Phosphorylation of Tyr1214 within VEGFR-2 triggers the recruitment of Nck and activation of Fyn leading to SAPK2/p38 activation and endothelial cell migration in response to VEGF.

PubMed ID: 16966330

DOI: 10.1074/jbc.m603928200

PubMed ID: 17004325

Title: Intrinsic tyrosine kinase activity is required for vascular endothelial growth factor receptor 2 ubiquitination, sorting and degradation in endothelial cells.

PubMed ID: 17004325

DOI: 10.1111/j.1600-0854.2006.00462.x

PubMed ID: 17303569

Title: Phosphorylation of tyrosine 801 of vascular endothelial growth factor receptor-2 is necessary for Akt-dependent endothelial nitric-oxide synthase activation and nitric oxide release from endothelial cells.

PubMed ID: 17303569

DOI: 10.1074/jbc.m609048200

PubMed ID: 19033661

Title: AIP1 functions as an endogenous inhibitor of VEGFR2-mediated signaling and inflammatory angiogenesis in mice.

PubMed ID: 19033661

DOI: 10.1172/jci36168

PubMed ID: 19136612

Title: Transcriptional profiling reveals a critical role for tyrosine phosphatase VE-PTP in regulation of VEGFR2 activity and endothelial cell morphogenesis.

PubMed ID: 19136612

DOI: 10.1096/fj.08-123810

PubMed ID: 18936167

Title: New role for the protein tyrosine phosphatase DEP-1 in Akt activation and endothelial cell survival.

PubMed ID: 18936167

DOI: 10.1128/mcb.01374-08

PubMed ID: 19834490

Title: VEGF-dependent tumor angiogenesis requires inverse and reciprocal regulation of VEGFR1 and VEGFR2.

PubMed ID: 19834490

DOI: 10.1038/cdd.2009.152

PubMed ID: 20179233

Title: Neuroblastoma progression correlates with downregulation of the lymphangiogenesis inhibitor sVEGFR-2.

PubMed ID: 20179233

DOI: 10.1158/1078-0432.ccr-09-1936

PubMed ID: 20224550

Title: VEGF receptor 2/-3 heterodimers detected in situ by proximity ligation on angiogenic sprouts.

PubMed ID: 20224550

DOI: 10.1038/emboj.2010.30

PubMed ID: 21539813

Title: The VEGFR2 receptor tyrosine kinase undergoes constitutive endosome-to-plasma membrane recycling.

PubMed ID: 21539813

DOI: 10.1016/j.bbrc.2011.04.093

PubMed ID: 20705758

Title: Blood vessel endothelial VEGFR-2 delays lymphangiogenesis: an endogenous trapping mechanism links lymph- and angiogenesis.

PubMed ID: 20705758

DOI: 10.1182/blood-2010-02-267427

PubMed ID: 17002866

Title: Differential roles of vascular endothelial growth factor receptor-1 and receptor-2 in angiogenesis.

PubMed ID: 17002866

DOI: 10.5483/bmbrep.2006.39.5.469

PubMed ID: 17658244

Title: Vascular endothelial growth factor receptor-2: structure, function, intracellular signalling and therapeutic inhibition.

PubMed ID: 17658244

DOI: 10.1016/j.cellsig.2007.05.013

PubMed ID: 18680722

Title: VEGF receptor protein-tyrosine kinases: structure and regulation.

PubMed ID: 18680722

DOI: 10.1016/j.bbrc.2008.07.121

PubMed ID: 19230644

Title: VEGFs and receptors involved in angiogenesis versus lymphangiogenesis.

PubMed ID: 19230644

DOI: 10.1016/j.ceb.2008.12.012

PubMed ID: 19761875

Title: Structure-function analysis of VEGF receptor activation and the role of coreceptors in angiogenic signaling.

PubMed ID: 19761875

DOI: 10.1016/j.bbapap.2009.09.002

PubMed ID: 20462514

Title: Vascular endothelial growth factor receptor-2 in breast cancer.

PubMed ID: 20462514

DOI: 10.1016/j.bbcan.2010.04.004

PubMed ID: 21779435

Title: Tyrosine kinase receptor Flt/VEGFR family: its characterization related to angiogenesis and cancer.

PubMed ID: 21779435

DOI: 10.1177/1947601910392987

PubMed ID: 21711246

Title: Signal transduction by vascular endothelial growth factor receptors.

PubMed ID: 21711246

DOI: 10.1042/bj20110301

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 21893193

Title: Programmed cell death 6 (PDCD6) inhibits angiogenesis through PI3K/mTOR/p70S6K pathway by interacting of VEGFR-2.

PubMed ID: 21893193

DOI: 10.1016/j.cellsig.2011.08.013

PubMed ID: 23199280

Title: VEGFR2 functions as an H(2)S-targeting receptor protein kinase with its novel Cys1045-Cys1024 disulfide bond serving as a specific molecular switch for hydrogen sulfide actions in vascular endothelial cells.

PubMed ID: 23199280

DOI: 10.1089/ars.2012.4565

PubMed ID: 23529610

Title: Vascular endothelial cell growth-activated XBP1 splicing in endothelial cells is crucial for angiogenesis.

PubMed ID: 23529610

DOI: 10.1161/circulationaha.112.001337

PubMed ID: 23792958

Title: Identification of PDCL3 as a novel chaperone protein involved in the generation of functional VEGF receptor 2.

PubMed ID: 23792958

DOI: 10.1074/jbc.m113.473173

PubMed ID: 25187647

Title: Structural basis for activation of trimeric Gi proteins by multiple growth factor receptors via GIV/Girdin.

PubMed ID: 25187647

DOI: 10.1091/mbc.e14-05-0978

PubMed ID: 26059764

Title: Hypoxia-induced expression of phosducin-like 3 regulates expression of VEGFR-2 and promotes angiogenesis.

PubMed ID: 26059764

DOI: 10.1007/s10456-015-9468-3

PubMed ID: 25825981

Title: EMMPRIN/CD147 is a novel coreceptor of VEGFR-2 mediating its activation by VEGF.

PubMed ID: 25825981

DOI: 10.18632/oncotarget.2870

PubMed ID: 35027734

Title: Cysteine oxidation of copper transporter CTR1 drives VEGFR2 signalling and angiogenesis.

PubMed ID: 35027734

DOI: 10.1038/s41556-021-00822-7

PubMed ID: 10368301

Title: Crystal structure of the kinase domain of human vascular endothelial growth factor receptor 2: a key enzyme in angiogenesis.

PubMed ID: 10368301

DOI: 10.1016/s0969-2126(99)80042-2

PubMed ID: 15837294

Title: Novel 4-amino-furo[2,3-d]pyrimidines as Tie-2 and VEGFR2 dual inhibitors.

PubMed ID: 15837294

DOI: 10.1016/j.bmcl.2005.03.034

PubMed ID: 17253678

Title: Evolution of a highly selective and potent 2-(pyridin-2-yl)-1,3,5-triazine Tie-2 kinase inhibitor.

PubMed ID: 17253678

DOI: 10.1021/jm061107l

PubMed ID: 18529047

Title: Design, synthesis, and biological evaluation of novel 3-aryl-4-(1H-indole-3yl)-1,5-dihydro-2H-pyrrole-2-ones as vascular endothelial growth factor receptor (VEGF-R) inhibitors.

PubMed ID: 18529047

DOI: 10.1021/jm8001185

PubMed ID: 20080685

Title: Direct contacts between extracellular membrane-proximal domains are required for VEGF receptor activation and cell signaling.

PubMed ID: 20080685

DOI: 10.1073/pnas.0914052107

PubMed ID: 20145116

Title: Structural determinants of growth factor binding and specificity by VEGF receptor 2.

PubMed ID: 20145116

DOI: 10.1073/pnas.0914318107

PubMed ID: 21827946

Title: The structural basis for the function of two anti-VEGF receptor 2 antibodies.

PubMed ID: 21827946

DOI: 10.1016/j.str.2011.01.019

PubMed ID: 11807987

Title: Somatic mutation of vascular endothelial growth factor receptors in juvenile hemangioma.

PubMed ID: 11807987

DOI: 10.1002/gcc.10028

PubMed ID: 16959974

Title: The consensus coding sequences of human breast and colorectal cancers.

PubMed ID: 16959974

DOI: 10.1126/science.1133427

PubMed ID: 17344846

Title: Patterns of somatic mutation in human cancer genomes.

PubMed ID: 17344846

DOI: 10.1038/nature05610

PubMed ID: 18931684

Title: Suppressed NFAT-dependent VEGFR1 expression and constitutive VEGFR2 signaling in infantile hemangioma.

PubMed ID: 18931684

DOI: 10.1038/nm.1877

Sequence Information:

  • Length: 1356
  • Mass: 151527
  • Checksum: 59E7C44B05CFEBB3
  • Sequence:
    • MQSKVLLAVA LWLCVETRAA SVGLPSVSLD LPRLSIQKDI LTIKANTTLQ ITCRGQRDLD 
WLWPNNQSGS EQRVEVTECS DGLFCKTLTI PKVIGNDTGA YKCFYRETDL ASVIYVYVQD 
YRSPFIASVS DQHGVVYITE NKNKTVVIPC LGSISNLNVS LCARYPEKRF VPDGNRISWD 
SKKGFTIPSY MISYAGMVFC EAKINDESYQ SIMYIVVVVG YRIYDVVLSP SHGIELSVGE 
KLVLNCTART ELNVGIDFNW EYPSSKHQHK KLVNRDLKTQ SGSEMKKFLS TLTIDGVTRS 
DQGLYTCAAS SGLMTKKNST FVRVHEKPFV AFGSGMESLV EATVGERVRI PAKYLGYPPP 
EIKWYKNGIP LESNHTIKAG HVLTIMEVSE RDTGNYTVIL TNPISKEKQS HVVSLVVYVP 
PQIGEKSLIS PVDSYQYGTT QTLTCTVYAI PPPHHIHWYW QLEEECANEP SQAVSVTNPY 
PCEEWRSVED FQGGNKIEVN KNQFALIEGK NKTVSTLVIQ AANVSALYKC EAVNKVGRGE 
RVISFHVTRG PEITLQPDMQ PTEQESVSLW CTADRSTFEN LTWYKLGPQP LPIHVGELPT 
PVCKNLDTLW KLNATMFSNS TNDILIMELK NASLQDQGDY VCLAQDRKTK KRHCVVRQLT 
VLERVAPTIT GNLENQTTSI GESIEVSCTA SGNPPPQIMW FKDNETLVED SGIVLKDGNR 
NLTIRRVRKE DEGLYTCQAC SVLGCAKVEA FFIIEGAQEK TNLEIIILVG TAVIAMFFWL 
LLVIILRTVK RANGGELKTG YLSIVMDPDE LPLDEHCERL PYDASKWEFP RDRLKLGKPL 
GRGAFGQVIE ADAFGIDKTA TCRTVAVKML KEGATHSEHR ALMSELKILI HIGHHLNVVN 
LLGACTKPGG PLMVIVEFCK FGNLSTYLRS KRNEFVPYKT KGARFRQGKD YVGAIPVDLK 
RRLDSITSSQ SSASSGFVEE KSLSDVEEEE APEDLYKDFL TLEHLICYSF QVAKGMEFLA 
SRKCIHRDLA ARNILLSEKN VVKICDFGLA RDIYKDPDYV RKGDARLPLK WMAPETIFDR 
VYTIQSDVWS FGVLLWEIFS LGASPYPGVK IDEEFCRRLK EGTRMRAPDY TTPEMYQTML 
DCWHGEPSQR PTFSELVEHL GNLLQANAQQ DGKDYIVLPI SETLSMEEDS GLSLPTSPVS 
CMEEEEVCDP KFHYDNTAGI SQYLQNSKRK SRPVSVKTFE DIPLEEPEVK VIPDDNQTDS 
GMVLASEELK TLEDRTKLSP SFGGMVPSKS RESVASEGSN QTSGYQSGYH SDDTDTTVYS 
SEEAELLKLI EIGVQTGSTA QILQPDSGTT LSSPPV

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.