Details for: PDE2A

Gene ID: 5138

Symbol: PDE2A

Ensembl ID: ENSG00000186642

Description: phosphodiesterase 2A

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 58.3496
    Cell Significance Index: -14.8000
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 11.9023
    Cell Significance Index: -14.6800
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 7.8041
    Cell Significance Index: -17.0800
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 3.7531
    Cell Significance Index: -14.8100
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 2.7819
    Cell Significance Index: 123.0500
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 2.5278
    Cell Significance Index: 36.7000
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 2.5210
    Cell Significance Index: 114.2700
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 2.4454
    Cell Significance Index: 92.6000
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 2.2129
    Cell Significance Index: 443.9100
  • Cell Name: endothelial cell of pericentral hepatic sinusoid (CL0019022)
    Fold Change: 2.1071
    Cell Significance Index: 16.6400
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: 1.8548
    Cell Significance Index: 52.9300
  • Cell Name: L6 intratelencephalic projecting glutamatergic neuron of the primary motor cortex (CL4023050)
    Fold Change: 1.6327
    Cell Significance Index: 21.7800
  • Cell Name: endothelial cell of periportal hepatic sinusoid (CL0019021)
    Fold Change: 1.4775
    Cell Significance Index: 5.1400
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 1.3140
    Cell Significance Index: 42.0900
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.1957
    Cell Significance Index: 118.2800
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 1.0782
    Cell Significance Index: 973.5300
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 1.0126
    Cell Significance Index: 68.0900
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.9311
    Cell Significance Index: 333.9800
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 0.9153
    Cell Significance Index: 16.1800
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 0.8935
    Cell Significance Index: 257.0800
  • Cell Name: endothelial cell of hepatic sinusoid (CL1000398)
    Fold Change: 0.8300
    Cell Significance Index: 7.8900
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.7333
    Cell Significance Index: 45.0700
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: 0.6730
    Cell Significance Index: 16.1400
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.6647
    Cell Significance Index: 9.5600
  • Cell Name: pyramidal neuron (CL0000598)
    Fold Change: 0.6467
    Cell Significance Index: 4.9600
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.6266
    Cell Significance Index: 101.9100
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.5452
    Cell Significance Index: 59.3000
  • Cell Name: lung microvascular endothelial cell (CL2000016)
    Fold Change: 0.5070
    Cell Significance Index: 4.2900
  • Cell Name: L6 corticothalamic-projecting glutamatergic cortical neuron (CL4023042)
    Fold Change: 0.5003
    Cell Significance Index: 5.5200
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.3794
    Cell Significance Index: 8.0800
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.3160
    Cell Significance Index: 21.8500
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.2385
    Cell Significance Index: 2.4700
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.2237
    Cell Significance Index: 13.4300
  • Cell Name: endothelial cell of sinusoid (CL0002262)
    Fold Change: 0.2149
    Cell Significance Index: 1.5800
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: 0.1836
    Cell Significance Index: 2.0000
  • Cell Name: hippocampal interneuron (CL1001569)
    Fold Change: 0.1797
    Cell Significance Index: 2.3300
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.1727
    Cell Significance Index: 32.8700
  • Cell Name: glomerular capillary endothelial cell (CL1001005)
    Fold Change: 0.1529
    Cell Significance Index: 0.5700
  • Cell Name: cerebral cortex neuron (CL0010012)
    Fold Change: 0.0410
    Cell Significance Index: 0.3900
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 0.0400
    Cell Significance Index: 5.8100
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0297
    Cell Significance Index: 55.8500
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0108
    Cell Significance Index: 6.8300
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0105
    Cell Significance Index: 0.3700
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.0045
    Cell Significance Index: 0.1300
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: 0.0014
    Cell Significance Index: 0.0200
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.0028
    Cell Significance Index: -0.0600
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.0062
    Cell Significance Index: -0.0700
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0073
    Cell Significance Index: -4.5300
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0074
    Cell Significance Index: -11.3300
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0075
    Cell Significance Index: -13.9200
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0076
    Cell Significance Index: -5.6300
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0100
    Cell Significance Index: -5.6600
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0109
    Cell Significance Index: -14.7800
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0131
    Cell Significance Index: -2.3700
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0189
    Cell Significance Index: -14.3200
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0190
    Cell Significance Index: -13.9300
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0249
    Cell Significance Index: -13.5800
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0283
    Cell Significance Index: -12.8600
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0310
    Cell Significance Index: -6.1600
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0343
    Cell Significance Index: -7.2200
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0391
    Cell Significance Index: -6.6800
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.0431
    Cell Significance Index: -1.1600
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.0546
    Cell Significance Index: -1.1800
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0615
    Cell Significance Index: -4.7200
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0693
    Cell Significance Index: -8.5200
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.0727
    Cell Significance Index: -1.4600
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.0767
    Cell Significance Index: -2.5100
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0819
    Cell Significance Index: -2.6100
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.0834
    Cell Significance Index: -1.7700
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0947
    Cell Significance Index: -13.0000
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.1019
    Cell Significance Index: -11.6400
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.1032
    Cell Significance Index: -2.0400
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.1103
    Cell Significance Index: -14.2500
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.1181
    Cell Significance Index: -3.1600
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.1184
    Cell Significance Index: -13.8000
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1282
    Cell Significance Index: -13.3500
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.1321
    Cell Significance Index: -16.9300
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1330
    Cell Significance Index: -15.2400
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.1353
    Cell Significance Index: -13.8300
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.1427
    Cell Significance Index: -3.5600
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: -0.1442
    Cell Significance Index: -1.8200
  • Cell Name: medium spiny neuron (CL1001474)
    Fold Change: -0.1578
    Cell Significance Index: -2.1300
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.1651
    Cell Significance Index: -7.1800
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.1768
    Cell Significance Index: -14.0000
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.1905
    Cell Significance Index: -14.2000
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.2217
    Cell Significance Index: -7.7700
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.2220
    Cell Significance Index: -13.6100
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.2251
    Cell Significance Index: -11.8200
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.2288
    Cell Significance Index: -14.7600
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.2423
    Cell Significance Index: -12.5900
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.2583
    Cell Significance Index: -5.3900
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.2609
    Cell Significance Index: -14.6400
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.2672
    Cell Significance Index: -12.5600
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.3076
    Cell Significance Index: -14.3400
  • Cell Name: L2/3 intratelencephalic projecting glutamatergic neuron (CL4030059)
    Fold Change: -0.3215
    Cell Significance Index: -4.2900
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.3279
    Cell Significance Index: -7.1800
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: -0.3394
    Cell Significance Index: -6.6800
  • Cell Name: neuron (CL0000540)
    Fold Change: -0.3439
    Cell Significance Index: -3.2600
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.3587
    Cell Significance Index: -5.4100
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.3735
    Cell Significance Index: -13.7100

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** 1. **Enzymatic activity**: PDE2A is a phosphodiesterase enzyme that hydrolyzes cAMP and cGMP, terminating their signaling effects. 2. **Tissue-specific expression**: PDE2A is highly expressed in neurons, endothelial cells, and kidney capillary endothelial cells, indicating its involvement in cardiovascular development and function. 3. **Regulation of signaling pathways**: PDE2A modulates cAMP and cGMP signaling pathways, influencing various cellular processes, including cardiovascular development, endothelial barrier function, and inflammatory responses. 4. **Negative regulation of signaling**: PDE2A negatively regulates cAMP- and cGMP-mediated signaling pathways, suggesting its role in fine-tuning cellular responses. **Pathways and Functions** 1. **Adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway**: PDE2A modulates the activity of adenylate cyclase, an enzyme involved in cAMP production, thereby regulating this signaling pathway. 2. **Camp-mediated signaling**: PDE2A negatively regulates cAMP-mediated signaling pathways, which are involved in various cellular processes, including cardiovascular development and inflammatory responses. 3. **Cgmp-mediated signaling**: PDE2A negatively regulates cGMP-mediated signaling pathways, which are involved in endothelial barrier function and vascular permeability regulation. 4. **Cellular response to mechanical stimulus**: PDE2A modulates the cellular response to mechanical stimuli, such as shear stress, which is essential for endothelial barrier function and vascular development. 5. **Cellular response to transforming growth factor beta**: PDE2A negatively regulates the cellular response to transforming growth factor beta, a cytokine involved in inflammatory responses and tissue remodeling. **Clinical Significance** 1. **Cardiovascular diseases**: PDE2A dysregulation has been implicated in various cardiovascular diseases, including hypertension, atherosclerosis, and heart failure. 2. **Neurological disorders**: PDE2A dysregulation has been linked to neurological disorders, such as Alzheimer's disease, Parkinson's disease, and multiple sclerosis. 3. **Inflammatory responses**: PDE2A modulates inflammatory responses, and its dysregulation can contribute to the development of inflammatory diseases, such as rheumatoid arthritis and asthma. 4. **Endothelial barrier dysfunction**: PDE2A dysregulation can lead to endothelial barrier dysfunction, which is a hallmark of various cardiovascular diseases. In conclusion, PDE2A is a critical enzyme involved in the regulation of cyclic nucleotide signaling pathways, and its dysregulation has been implicated in various cardiovascular and neurological diseases. Further research is needed to fully elucidate the role of PDE2A in human health and disease.

Genular Protein ID: 1345664382

Symbol: PDE2A_HUMAN

Name: Cyclic GMP-stimulated phosphodiesterase

UniProtKB Accession Codes:

O00408 B2R646 B3KRV5 E9PGI1 F6W5Z0 Q5J791 Q5J792 Q5J793 Q6ZMR1

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 4 CDD 1 CTD 1 ChEBI 24 ChEMBL 1 ChiTaRS 1 DIP 1 DNASU 1 DisGeNET 1 DrugBank 8 DrugCentral 1 EC 1 ELM 1 EMBL 9 Ensembl 5 EvolutionaryTrace 1 ExpressionAtlas 1 GO 51 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GuidetoPHARMACOLOGY 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 7 KEGG 1 MANE-Select 1 MIM 3 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PDB 41 PDBsum 41 PRINTS 1 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 4 Pumba 1 RNAct 1 Reactome 2 RefSeq 4 Rhea 6 SIGNOR 1 SMART 2 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9210593

Title: Isolation and characterization of human cDNAs encoding a cGMP-stimulated 3',5'-cyclic nucleotide phosphodiesterase.

PubMed ID: 9210593

DOI: 10.1016/s0378-1119(97)00046-2

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16554811

Title: Human chromosome 11 DNA sequence and analysis including novel gene identification.

PubMed ID: 16554811

DOI: 10.1038/nature04632

PubMed ID: 19632989

Title: Dual acylation of PDE2A splice variant 3: targeting to synaptic membranes.

PubMed ID: 19632989

DOI: 10.1074/jbc.m109.017194

PubMed ID: 19369195

Title: Large-scale proteomics analysis of the human kinome.

PubMed ID: 19369195

DOI: 10.1074/mcp.m800588-mcp200

PubMed ID: 20213681

Title: Strategy for comprehensive identification of human N-myristoylated proteins using an insect cell-free protein synthesis system.

PubMed ID: 20213681

DOI: 10.1002/pmic.200900783

PubMed ID: 24705027

Title: Role of phosphodiesterase 2 in growth and invasion of human malignant melanoma cells.

PubMed ID: 24705027

DOI: 10.1016/j.cellsig.2014.03.031

PubMed ID: 28463107

Title: PDE2A2 regulates mitochondria morphology and apoptotic cell death via local modulation of cAMP/PKA signalling.

PubMed ID: 28463107

DOI: 10.7554/elife.21374

PubMed ID: 29392776

Title: A homozygous loss-of-function mutation in PDE2A associated to early-onset hereditary chorea.

PubMed ID: 29392776

DOI: 10.1002/mds.27286

PubMed ID: 32467598

Title: Biallelic PDE2A variants: a new cause of syndromic paroxysmal dyskinesia.

PubMed ID: 32467598

DOI: 10.1038/s41431-020-0641-9

PubMed ID: 32196122

Title: A homozygous splicing mutation in PDE2A in a family with atypical Rett syndrome.

PubMed ID: 32196122

DOI: 10.1002/mds.28023

PubMed ID: 15938621

Title: Structural determinants for inhibitor specificity and selectivity in PDE2A using the wheat germ in vitro translation system.

PubMed ID: 15938621

DOI: 10.1021/bi047313h

PubMed ID: 19828435

Title: Mechanism for the allosteric regulation of phosphodiesterase 2A deduced from the X-ray structure of a near full-length construct.

PubMed ID: 19828435

DOI: 10.1073/pnas.0907635106

PubMed ID: 23899287

Title: X-ray crystal structure of phosphodiesterase 2 in complex with a highly selective, nanomolar inhibitor reveals a binding-induced pocket important for selectivity.

PubMed ID: 23899287

DOI: 10.1021/ja404449g

Sequence Information:

  • Length: 941
  • Mass: 105717
  • Checksum: 9797609B487FD64E
  • Sequence:
    • MGQACGHSIL CRSQQYPAAR PAEPRGQQVF LKPDEPPPPP QPCADSLQDA LLSLGSVIDI 
SGLQRAVKEA LSAVLPRVET VYTYLLDGES QLVCEDPPHE LPQEGKVREA IISQKRLGCN 
GLGFSDLPGK PLARLVAPLA PDTQVLVMPL ADKEAGAVAA VILVHCGQLS DNEEWSLQAV 
EKHTLVALRR VQVLQQRGPR EAPRAVQNPP EGTAEDQKGG AAYTDRDRKI LQLCGELYDL 
DASSLQLKVL QYLQQETRAS RCCLLLVSED NLQLSCKVIG DKVLGEEVSF PLTGCLGQVV 
EDKKSIQLKD LTSEDVQQLQ SMLGCELQAM LCVPVISRAT DQVVALACAF NKLEGDLFTD 
EDEHVIQHCF HYTSTVLTST LAFQKEQKLK CECQALLQVA KNLFTHLDDV SVLLQEIITE 
ARNLSNAEIC SVFLLDQNEL VAKVFDGGVV DDESYEIRIP ADQGIAGHVA TTGQILNIPD 
AYAHPLFYRG VDDSTGFRTR NILCFPIKNE NQEVIGVAEL VNKINGPWFS KFDEDLATAF 
SIYCGISIAH SLLYKKVNEA QYRSHLANEM MMYHMKVSDD EYTKLLHDGI QPVAAIDSNF 
ASFTYTPRSL PEDDTSMAIL SMLQDMNFIN NYKIDCPTLA RFCLMVKKGY RDPPYHNWMH 
AFSVSHFCYL LYKNLELTNY LEDIEIFALF ISCMCHDLDH RGTNNSFQVA SKSVLAALYS 
SEGSVMERHH FAQAIAILNT HGCNIFDHFS RKDYQRMLDL MRDIILATDL AHHLRIFKDL 
QKMAEVGYDR NNKQHHRLLL CLLMTSCDLS DQTKGWKTTR KIAELIYKEF FSQGDLEKAM 
GNRPMEMMDR EKAYIPELQI SFMEHIAMPI YKLLQDLFPK AAELYERVAS NREHWTKVSH 
KFTIRGLPSN NSLDFLDEEY EVPDLDGTRA PINGCCSLDA E

Genular Protein ID: 4152252911

Symbol: Q8IW54_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q8IW54

Database IDs:

ARBA 3 AlphaFoldDB 1 BioGRID-ORCS 1 CDD 1 CTD 1 ChEBI 10 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 2 GO 19 Gene3D 2 InterPro 7 KEGG 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PIRSR 3 PRINTS 1 PROSITE 3 PeptideAtlas 1 Pfam 2 PharmGKB 1 RefSeq 4 RuleBase 1 SAM 1 SMART 2 SUPFAM 2

Citations:

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 941
  • Mass: 105649
  • Checksum: 93028FC28CB54D6B
  • Sequence:
    • MGQACGHSIL CRSQQYPAAR PAEPRGQQVF LKPDEPPPPP QQCADSLQDA LLSLGSVIDI 
SGLQRAVKEA LSAVLPRVET VYTYLLDGES QLVCEDPPHE LPQEGKVREA IISQKRLGCN 
GLGFSDLPGK PLARLVAPLA PDTQVLVMPL ADKEAGAVAA VILVHCGQLS DNEEWSLQAV 
EKHTLVALRR VQVLQQRGPR EAPRAVQNPP EGTAEDQKGG AAYTDRDRKI LQLCGELYDL 
DASSLQLKVL QYLQQETRAS RCCLLLVSED NLQLSCKVIG DKVLGEEVSF PLTGCLGQVV 
EDKKSIQLKD LTSEDVQQLQ SMLGCELQAM LCVPVISRAT DQVVALACAF NKLEGDLFTD 
EDEHVIQHCF HYTSTVLTST LAFQKEQKLK CECQALLQVA KNLFTHLDDV SVLLQEIITE 
ARNLSNAEIC SVFLLDQNEL VAKVFDGGVV DDESYEIRIP ADQGIAGHVA TTGQILNIPD 
AYAHPLFYRG VDDSTGFRTR NILCFPIKNE NQEVIGVAEL VNKINGPWFS KFDEDLATAF 
SIYCGISIAH SLLYKKVNEA QYRSHLANEM MMYHMKVSDD EYTKLLHDGI QPVAAIDSNF 
ASFTYTPRSL PEDDTSMAIL SMLQDMNFIN NYKIDCPTLA RFCLMVKKGY RDPPYHNWMH 
AFSVSHFCYL LYKNLELTNY LEDIEIFALF ISCMCHDLDH RGTNNSFQVA SKSVLAALYS 
SEGSVMERHH FAQAIAILNT HGCNIFDHFS RKDYQRMLDL MRDIILATDL AHHLRIFKDL 
QKMAEVGYDR NNKQHHRLLL CLLMTSCDLS DQTKGWKTTR KIAELIYKEF FSQGDLEKAM 
GNRPMEMMDR EKAYIPELQI SFMEHIAMPI YKLLQDLFPK AAELYERVAS NGEHWTKVSH 
KFTIRGIPSN NSLDFLDEEY EVPDLDGTRA PINGCCSLDA E

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.