Details for: EPHB4

Gene ID: 2050

Symbol: EPHB4

Ensembl ID: ENSG00000196411

Description: EPH receptor B4

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 78.1766
    Cell Significance Index: -12.1600
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 49.9520
    Cell Significance Index: -12.6700
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 28.3072
    Cell Significance Index: -11.5000
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 27.3022
    Cell Significance Index: -12.8900
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 10.4627
    Cell Significance Index: -12.9000
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 3.3020
    Cell Significance Index: -13.0300
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 3.2483
    Cell Significance Index: 86.7400
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 2.7846
    Cell Significance Index: 275.4600
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 2.0536
    Cell Significance Index: 106.9700
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 1.7024
    Cell Significance Index: 198.3900
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 1.6292
    Cell Significance Index: 43.6600
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 1.3338
    Cell Significance Index: 1204.3600
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 1.1311
    Cell Significance Index: 12.8500
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 1.0561
    Cell Significance Index: 114.8700
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.9911
    Cell Significance Index: 14.2600
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.9694
    Cell Significance Index: 157.6600
  • Cell Name: endocardial cell (CL0002350)
    Fold Change: 0.8816
    Cell Significance Index: 5.2100
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.7044
    Cell Significance Index: 139.8000
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.6239
    Cell Significance Index: 17.9800
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.5027
    Cell Significance Index: 14.0500
  • Cell Name: endothelial cell of hepatic sinusoid (CL1000398)
    Fold Change: 0.4402
    Cell Significance Index: 4.1900
  • Cell Name: endothelial cell of periportal hepatic sinusoid (CL0019021)
    Fold Change: 0.4383
    Cell Significance Index: 1.5300
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 0.4318
    Cell Significance Index: 6.4700
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.4176
    Cell Significance Index: 28.8800
  • Cell Name: lung microvascular endothelial cell (CL2000016)
    Fold Change: 0.4101
    Cell Significance Index: 3.4700
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.3937
    Cell Significance Index: 10.7200
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.3872
    Cell Significance Index: 53.1700
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 0.3342
    Cell Significance Index: 4.2800
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.3027
    Cell Significance Index: 13.7200
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.2550
    Cell Significance Index: 31.3600
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.2370
    Cell Significance Index: 11.0500
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.2317
    Cell Significance Index: 126.5200
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.2099
    Cell Significance Index: 92.8000
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 0.2035
    Cell Significance Index: 4.2600
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.2025
    Cell Significance Index: 36.5100
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.1556
    Cell Significance Index: 3.3700
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.1294
    Cell Significance Index: 6.0800
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.1235
    Cell Significance Index: 2.6300
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.1079
    Cell Significance Index: 20.5400
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: 0.1043
    Cell Significance Index: 0.6300
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.0945
    Cell Significance Index: 4.9100
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0581
    Cell Significance Index: 2.0400
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.0566
    Cell Significance Index: 4.0000
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: 0.0369
    Cell Significance Index: 0.5600
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.0366
    Cell Significance Index: 4.6900
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.0253
    Cell Significance Index: 3.2700
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.0164
    Cell Significance Index: 0.3400
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.0121
    Cell Significance Index: 0.6800
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.0034
    Cell Significance Index: 2.5800
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0019
    Cell Significance Index: 3.5600
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0013
    Cell Significance Index: 1.9300
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0007
    Cell Significance Index: -1.2700
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0060
    Cell Significance Index: -0.1000
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0067
    Cell Significance Index: -4.8800
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0084
    Cell Significance Index: -11.3800
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0091
    Cell Significance Index: -1.5600
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0129
    Cell Significance Index: -8.1700
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: -0.0173
    Cell Significance Index: -0.3100
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0174
    Cell Significance Index: -7.9100
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.0174
    Cell Significance Index: -0.1800
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0192
    Cell Significance Index: -14.2300
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0210
    Cell Significance Index: -13.1400
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.0215
    Cell Significance Index: -0.6900
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0256
    Cell Significance Index: -14.4200
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0275
    Cell Significance Index: -9.8500
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.0284
    Cell Significance Index: -1.8300
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0358
    Cell Significance Index: -2.6700
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0391
    Cell Significance Index: -7.8500
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0408
    Cell Significance Index: -5.9300
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0432
    Cell Significance Index: -12.4400
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.0504
    Cell Significance Index: -1.2600
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.0528
    Cell Significance Index: -0.7200
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.0627
    Cell Significance Index: -1.6500
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0647
    Cell Significance Index: -7.4100
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.0663
    Cell Significance Index: -2.3100
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0671
    Cell Significance Index: -14.1400
  • Cell Name: endothelial cell of uterus (CL0009095)
    Fold Change: -0.0767
    Cell Significance Index: -0.4800
  • Cell Name: syncytiotrophoblast cell (CL0000525)
    Fold Change: -0.1011
    Cell Significance Index: -0.9600
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.1047
    Cell Significance Index: -10.6900
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.1053
    Cell Significance Index: -12.4200
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1211
    Cell Significance Index: -12.6100
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.1501
    Cell Significance Index: -9.2000
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.1506
    Cell Significance Index: -11.5600
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.1509
    Cell Significance Index: -11.9500
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.1512
    Cell Significance Index: -7.6400
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.1835
    Cell Significance Index: -11.2800
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.1847
    Cell Significance Index: -5.4400
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: -0.1926
    Cell Significance Index: -3.2400
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.1930
    Cell Significance Index: -12.9800
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.1961
    Cell Significance Index: -12.3600
  • Cell Name: endothelial cell of pericentral hepatic sinusoid (CL0019022)
    Fold Change: -0.2166
    Cell Significance Index: -1.7100
  • Cell Name: epithelial cell of uterus (CL0002149)
    Fold Change: -0.2234
    Cell Significance Index: -3.1000
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: -0.2367
    Cell Significance Index: -3.3200
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: -0.2715
    Cell Significance Index: -3.8900
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.2765
    Cell Significance Index: -14.5200
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.2941
    Cell Significance Index: -13.0100
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: -0.3001
    Cell Significance Index: -4.4300
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.3152
    Cell Significance Index: -4.7500
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.3206
    Cell Significance Index: -9.1900
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.3274
    Cell Significance Index: -12.0200

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** EPHB4 is a member of the Eph family of receptor tyrosine kinases, which are characterized by their ability to bind to ephrin ligands. The EPHB4 receptor is specifically expressed in various cell types, including endothelial cells, placental trophoblasts, and GABAergic interneurons in the cerebral cortex. The receptor's ligand, ephrin-B4, is primarily expressed in the heart and developing nervous system. **Pathways and Functions:** EPHB4 is involved in several signaling pathways, including: 1. **Angiogenesis:** EPHB4 plays a crucial role in regulating angiogenesis, the process of new blood vessel formation. The receptor's interaction with ephrin-B4 promotes cell migration and sprouting, which is essential for vascular development and tissue repair. 2. **Cell Migration:** EPHB4 is also involved in cell migration, particularly in the context of tissue development and repair. The receptor's signaling pathway regulates the movement of cells, including endothelial cells and GABAergic interneurons. 3. **Developmental Biology:** EPHB4 is essential for the development of various tissues, including the heart, nervous system, and placenta. The receptor's interaction with ephrin-B4 regulates cell migration, proliferation, and differentiation during embryonic development. 4. **Ephrin Signaling:** EPHB4 is a key component of the ephrin signaling pathway, which regulates cell adhesion, repulsion, and migration. The receptor's interaction with ephrin-B4 promotes forward signaling, which is essential for cell migration and angiogenesis. **Clinical Significance:** Dysregulation of EPHB4 has been implicated in various diseases, including: 1. **Cancer:** EPHB4 is often overexpressed in cancer cells, particularly in tumors of the lung, breast, and colon. The receptor's signaling pathway promotes angiogenesis and cell migration, which can contribute to tumor growth and metastasis. 2. **Cardiovascular Disease:** EPHB4 has been implicated in the development of cardiovascular disease, including atherosclerosis and cardiac hypertrophy. The receptor's interaction with ephrin-B4 regulates endothelial cell migration and angiogenesis, which is essential for vascular development and repair. 3. **Neurological Disorders:** EPHB4 has been implicated in the development of neurological disorders, including Alzheimer's disease and Parkinson's disease. The receptor's interaction with ephrin-B4 regulates GABAergic interneuron migration and function, which is essential for normal brain function. In conclusion, EPHB4 is a critical gene that plays a significant role in angiogenesis, cell migration, and developmental biology. Its dysregulation has been implicated in various diseases, highlighting the importance of this gene in maintaining tissue homeostasis and preventing disease. Further research is necessary to fully elucidate the mechanisms by which EPHB4 regulates these processes and to explore its therapeutic potential in the treatment of diseases associated with its dysregulation.

Genular Protein ID: 1534144337

Symbol: EPHB4_HUMAN

Name: Ephrin type-B receptor 4

UniProtKB Accession Codes:

P54760 B5A970 B5A971 B5A972 Q7Z635 Q9BTA5 Q9BXP0

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BMRB 1 BRENDA 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 4 CPTAC 3 CPTC 1 CTD 1 ChEBI 7 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 11 DrugCentral 1 EC 2 EMBL 7 Ensembl 2 EvolutionaryTrace 1 ExpressionAtlas 1 GO 14 Gene3D 6 GeneCards 1 GeneReviews 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyConnect 1 GlyCosmos 1 GlyGen 1 GuidetoPHARMACOLOGY 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 21 KEGG 1 MANE-Select 1 MIM 5 MINT 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 NIAGADS 1 OMA 1 OpenTargets 1 Orphanet 4 OrthoDB 1 PANTHER 2 PDB 23 PDBsum 23 PIR 1 PIRSF 1 PRINTS 1 PRO 1 PROSITE 9 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 6 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 4 RefSeq 1 Rhea 3 SASBDB 1 SIGNOR 1 SMART 5 SMR 1 STRING 1 SUPFAM 5 SignaLink 1 SwissPalm 1 TCDB 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8188704

Title: Cloning and characterization of HTK, a novel transmembrane tyrosine kinase of the EPH subfamily.

PubMed ID: 8188704

DOI: 10.1016/s0021-9258(17)36776-5

PubMed ID: 11239002

Title: Comparative analysis of the gene-dense ACHE/TFR2 region on human chromosome 7q22 with the orthologous region on mouse chromosome 5.

PubMed ID: 11239002

DOI: 10.1093/nar/29.6.1352

PubMed ID: 18593464

Title: Novel splice variants derived from the receptor tyrosine kinase superfamily are potential therapeutics for rheumatoid arthritis.

PubMed ID: 18593464

DOI: 10.1186/ar2447

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9267020

Title: Unified nomenclature for Eph family receptors and their ligands, the ephrins.

PubMed ID: 9267020

DOI: 10.1016/s0092-8674(00)80500-0

PubMed ID: 12734395

Title: Forward EphB4 signaling in endothelial cells controls cellular repulsion and segregation from ephrinB2 positive cells.

PubMed ID: 12734395

DOI: 10.1242/jcs.00426

PubMed ID: 16424904

Title: EphB4 controls blood vascular morphogenesis during postnatal angiogenesis.

PubMed ID: 16424904

DOI: 10.1038/sj.emboj.7600949

PubMed ID: 18691976

Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.

PubMed ID: 18691976

DOI: 10.1016/j.molcel.2008.07.007

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 19369195

Title: Large-scale proteomics analysis of the human kinome.

PubMed ID: 19369195

DOI: 10.1074/mcp.m800588-mcp200

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 16867992

Title: Structural and biophysical characterization of the EphB4*ephrinB2 protein-protein interaction and receptor specificity.

PubMed ID: 16867992

DOI: 10.1074/jbc.m605766200

PubMed ID: 16472751

Title: Structure and thermodynamic characterization of the EphB4/Ephrin-B2 antagonist peptide complex reveals the determinants for receptor specificity.

PubMed ID: 16472751

DOI: 10.1016/j.str.2005.11.011

PubMed ID: 17344846

Title: Patterns of somatic mutation in human cancer genomes.

PubMed ID: 17344846

DOI: 10.1038/nature05610

PubMed ID: 27400125

Title: EPHB4 kinase-inactivating mutations cause autosomal dominant lymphatic-related hydrops fetalis.

PubMed ID: 27400125

DOI: 10.1172/jci85794

PubMed ID: 28687708

Title: Germline loss-of-function mutations in EPHB4 cause a second form of capillary malformation-arteriovenous malformation (CM-AVM2) deregulating RAS-MAPK signaling.

PubMed ID: 28687708

DOI: 10.1161/circulationaha.116.026886

PubMed ID: 28730721

Title: EPHB4 mutation implicated in capillary malformation-arteriovenous malformation syndrome: A case report.

PubMed ID: 28730721

DOI: 10.1111/pde.13208

PubMed ID: 29444212

Title: Loss of function mutations in EPHB4 are responsible for vein of Galen aneurysmal malformation.

PubMed ID: 29444212

DOI: 10.1093/brain/awy020

PubMed ID: 30578106

Title: Mutations in chromatin modifier and ephrin signaling genes in vein of Galen malformation.

PubMed ID: 30578106

DOI: 10.1016/j.neuron.2018.11.041

Sequence Information:

  • Length: 987
  • Mass: 108270
  • Checksum: 11A004622F194706
  • Sequence:
    • MELRVLLCWA SLAAALEETL LNTKLETADL KWVTFPQVDG QWEELSGLDE EQHSVRTYEV 
CDVQRAPGQA HWLRTGWVPR RGAVHVYATL RFTMLECLSL PRAGRSCKET FTVFYYESDA 
DTATALTPAW MENPYIKVDT VAAEHLTRKR PGAEATGKVN VKTLRLGPLS KAGFYLAFQD 
QGACMALLSL HLFYKKCAQL TVNLTRFPET VPRELVVPVA GSCVVDAVPA PGPSPSLYCR 
EDGQWAEQPV TGCSCAPGFE AAEGNTKCRA CAQGTFKPLS GEGSCQPCPA NSHSNTIGSA 
VCQCRVGYFR ARTDPRGAPC TTPPSAPRSV VSRLNGSSLH LEWSAPLESG GREDLTYALR 
CRECRPGGSC APCGGDLTFD PGPRDLVEPW VVVRGLRPDF TYTFEVTALN GVSSLATGPV 
PFEPVNVTTD REVPPAVSDI RVTRSSPSSL SLAWAVPRAP SGAVLDYEVK YHEKGAEGPS 
SVRFLKTSEN RAELRGLKRG ASYLVQVRAR SEAGYGPFGQ EHHSQTQLDE SEGWREQLAL 
IAGTAVVGVV LVLVVIVVAV LCLRKQSNGR EAEYSDKHGQ YLIGHGTKVY IDPFTYEDPN 
EAVREFAKEI DVSYVKIEEV IGAGEFGEVC RGRLKAPGKK ESCVAIKTLK GGYTERQRRE 
FLSEASIMGQ FEHPNIIRLE GVVTNSMPVM ILTEFMENGA LDSFLRLNDG QFTVIQLVGM 
LRGIASGMRY LAEMSYVHRD LAARNILVNS NLVCKVSDFG LSRFLEENSS DPTYTSSLGG 
KIPIRWTAPE AIAFRKFTSA SDAWSYGIVM WEVMSFGERP YWDMSNQDVI NAIEQDYRLP 
PPPDCPTSLH QLMLDCWQKD RNARPRFPQV VSALDKMIRN PASLKIVARE NGGASHPLLD 
QRQPHYSAFG SVGEWLRAIK MGRYEESFAA AGFGSFELVS QISAEDLLRI GVTLAGHQKK 
ILASVQHMKS QAKPGTPGGT GGPAPQY

Genular Protein ID: 2846092560

Symbol: Q96L35_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q96L35

Database IDs:

ARBA 15 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CDD 3 CTD 1 ChEBI 7 ChiTaRS 1 DNASU 1 DisGeNET 1 EC 1 EMBL 5 Ensembl 2 GO 3 Gene3D 6 GeneTree 1 HGNC 1 HOGENOM 1 InterPro 20 KEGG 1 NCBI Taxonomy 1 NIAGADS 1 OrthoDB 1 PANTHER 2 PIRSF 1 PIRSR 3 PRINTS 2 PROSITE 12 PROSITE-ProRule 1 PeptideAtlas 1 Pfam 6 PharmGKB 1 Proteomes 2 ProteomicsDB 2 RefSeq 1 Rhea 3 SAM 3 SMART 4 SUPFAM 5 UCSC 1 VEuPathDB 1

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 11181995

Title: The sequence of the human genome.

PubMed ID: 11181995

DOI: 10.1126/science.1058040

PubMed ID: 12853948

Title: The DNA sequence of human chromosome 7.

PubMed ID: 12853948

DOI: 10.1038/nature01782

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

PubMed ID: 18691976

Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.

PubMed ID: 18691976

DOI: 10.1016/j.molcel.2008.07.007

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 19369195

Title: Large-scale proteomics analysis of the human kinome.

PubMed ID: 19369195

DOI: 10.1074/mcp.M800588-MCP200

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

Sequence Information:

  • Length: 935
  • Mass: 102558
  • Checksum: 47F61EBB367F00E3
  • Sequence:
    • MELRVLLCWA SLAAALEETL LNTKLETADL KWVTFPQVDG QWEELSGLDE EQHSVRTYEV 
CDVQRAPGQA HWLRTGWVPR RGAVHVYATL RFTMLECLSL PRAGRSCKET FTVFYYESDA 
DTATALTPAW MENPYIKVDT VAAEHLTRKR PGAEATGKVN VKTLRLGPLS KAGFYLAFQD 
QGACMALLSL HLFYKKCAQL TVNLTRFPET VPRELVVPVA GSCVVDAVPA PGPSPSLYCR 
EDGQWAEQPV TGCSCAPGFE AAEGNTKCRA CAQGTFKPLS GEGSCQPCPA NSHSNTIGSA 
VCQCRVGYFR ARTDPRGAPC TTPPSAPRSV VSRLNGSSLH LEWSAPLESG GREDLTYALR 
CRECRPGGSC APCGGDLTFD PGPRDLVEPW VVVRGLRPDF TYTFEVTALN GVSSLATGPV 
PFEPVNVTTD REVPPAVSDI RVTRSSPSSL SLAWAVPRAP SGAVLDYEVK YHEKGAEGPS 
SVRFLKTSEN RAELRGLKRG ASYLVQVRAR SEAGYGPFGQ EHHSQTQLDE SEGWREQLAL 
IAGTAVVGVV LVLVVIVVAV LCLRKQSNGR EAEYSDKHGQ YLIGHGTKVY IDPFTYEDPN 
EAVREFAKEI DVSYVKIEEV IGAGEFGEVC RGRLKAPGKK ESCVAIKTLK GGYTERQRRE 
FLSEASIMGQ FEHPNIIRLE GVVTNSMPVM ILTEFMENGA LDSFLRLNDG QFTVIQLVGM 
LRGIASGMRY LAEMSYVHRD LAARNILVNS NLVCKVSDFG LSRFLEENSS DPTYTSSLGG 
KIPIRWTAPE AIAFRKFTSA SDAWSYGIVM WEVMSFGERP YWDMSNQDVI NAIEQDYRLP 
PPPDCPTSLH QLMLDCWQKD RNARPRFPQV VSALDKMIRN PASLKIVARE NGGDLLRIGV 
TLAGHQKKIL ASVQHMKSQA KPGTPGGTGG PAPQY

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.