Details for: PRSS23

Gene ID: 11098

Gene Type:  Protein-coding  - A gene that serves as a template for producing a messenger RNA (mRNA) molecule, which is then translated into a functional protein.

Symbol: PRSS23

Ensembl ID: ENSG00000150687

Description: serine protease 23

Cell Significance Landscape

Associated with

Significant Cells

Cell Significance Index (CSI) scores for the chosen context(s)

  • respiratory suprabasal cell CL4033048
    CSI 48.58
    rCSI 62.31%
    PRS 92.9
  • nasal mucosa goblet cell CL0002480
    CSI 32.16
    rCSI 37.3%
    PRS 91.75
  • tracheal goblet cell CL1000329
    CSI 30.51
    rCSI 66.61%
    PRS 93.47
  • club cell CL0000158
    CSI 30.29
    rCSI 44.37%
    PRS 87.56
  • pulmonary artery endothelial cell CL1001568
    CSI 27.86
    rCSI 37.91%
    PRS 95.28
  • secretory cell CL0000151
    CSI 26.36
    rCSI 27.51%
    PRS 90.56
  • pancreatic D cell CL0000173
    CSI 25.35
    rCSI 24.93%
    PRS 93.05
  • respiratory basal cell CL0002633
    CSI 25.16
    rCSI 26.07%
    PRS 92.92
  • effector CD8-positive, alpha-beta T cell CL0001050
    CSI 23.32
    rCSI 17.74%
    PRS 98.26
  • multi-ciliated epithelial cell CL0005012
    CSI 22.66
    rCSI 22.62%
    PRS 86.22
  • duct epithelial cell CL0000068
    CSI 21.47
    rCSI 31.41%
    PRS 94.43
  • pancreatic ductal cell CL0002079
    CSI 21.43
    rCSI 41.67%
    PRS 92.74
  • endothelial cell of pericentral hepatic sinusoid CL0019022
    CSI 20.32
    rCSI 62.61%
    PRS 92.83
  • blood vessel endothelial cell CL0000071
    CSI 18.9
    rCSI 39.22%
    PRS 89.91
  • endothelial cell of periportal hepatic sinusoid CL0019021
    CSI 17.85
    rCSI 81.9%
    PRS 93.07
  • bronchial goblet cell CL1000312
    CSI 17.54
    rCSI 70.1%
    PRS 94.12
  • type B pancreatic cell CL0000169
    CSI 16.01
    rCSI 35.44%
    PRS 91.44
  • luminal epithelial cell of mammary gland CL0002326
    CSI 13.98
    rCSI 25.4%
    PRS 95.46
  • endothelial cell of placenta CL0009092
    CSI 12.32
    rCSI 60.71%
    PRS 94.55
  • sncg GABAergic cortical interneuron CL4023015
    CSI 12.2
    rCSI 19.62%
    PRS 80.43
  • ionocyte CL0005006
    CSI 12.13
    rCSI 13%
    PRS 92.76
  • vein endothelial cell CL0002543
    CSI 12.02
    rCSI 32.79%
    PRS 93.89
  • adipocyte CL0000136
    CSI 11.78
    rCSI 15.12%
    PRS 84.11
  • lung endothelial cell CL1001567
    CSI 11.55
    rCSI 26.92%
    PRS 96.18
  • CD8-positive, alpha-beta cytotoxic T cell CL0000794
    CSI 11.41
    rCSI 13.62%
    PRS 97.95
  • pancreatic A cell CL0000171
    CSI 11.28
    rCSI 11.81%
    PRS 93.12
  • fibroblast of lung CL0002553
    CSI 11.22
    rCSI 10.45%
    PRS 92.77
  • collagen secreting cell CL0000667
    CSI 10.79
    rCSI 61.91%
    PRS 94.01
  • mucus secreting cell CL0000319
    CSI 10.74
    rCSI 17.06%
    PRS 95.18
  • dendritic cell CL0000451
    CSI 10.55
    rCSI 13%
    PRS 91.03
  • vein endothelial cell of respiratory system CL4033008
    CSI 10.16
    rCSI 69.74%
    PRS 94.25
  • myofibroblast cell CL0000186
    CSI 10.07
    rCSI 13.95%
    PRS 88.46
  • fibroblast of breast CL4006000
    CSI 10.04
    rCSI 42.2%
    PRS 93
  • astrocyte of the cerebral cortex CL0002605
    CSI 9.91
    rCSI 22.22%
    PRS 79.83
  • basal cell of epithelium of trachea CL1000348
    CSI 9.7
    rCSI 68.44%
    PRS 91.99
  • tracheobronchial serous cell CL0019001
    CSI 9.54
    rCSI 41.22%
    PRS 93.36
  • lung pericyte CL0009089
    CSI 9.48
    rCSI 25.01%
    PRS 94.82
  • endothelial cell of uterus CL0009095
    CSI 9.45
    rCSI 69.13%
    PRS 95.34
  • CD16-positive, CD56-dim natural killer cell, human CL0000939
    CSI 9.27
    rCSI 6.18%
    PRS 96.24
  • pancreatic PP cell CL0002275
    CSI 9.16
    rCSI 36.48%
    PRS 94.23
  • stromal cell of ovary CL0002132
    CSI 9.13
    rCSI 25.09%
    PRS 94.16
  • pvalb GABAergic cortical interneuron CL4023018
    CSI 9.12
    rCSI 11.34%
    PRS 77.27
  • pulmonary capillary endothelial cell CL4028001
    CSI 9.07
    rCSI 17.3%
    PRS 96.01
  • retinal blood vessel endothelial cell CL0002585
    CSI 8.97
    rCSI 14.33%
    PRS 93.48
  • intestinal epithelial cell CL0002563
    CSI 8.89
    rCSI 9.29%
    PRS 89.23
  • hepatic stellate cell CL0000632
    CSI 8.75
    rCSI 32.77%
    PRS 87.47
  • endothelial cell of lymphatic vessel CL0002138
    CSI 8.65
    rCSI 17.13%
    PRS 92.69
  • chondrocyte CL0000138
    CSI 8.64
    rCSI 13.75%
    PRS 87.25
  • alveolar adventitial fibroblast CL4028006
    CSI 8.45
    rCSI 13.35%
    PRS 92.29
  • Schwann cell CL0002573
    CSI 8.3
    rCSI 23.59%
    PRS 88.22
  • kidney loop of Henle thin descending limb epithelial cell CL1001111
    CSI 8.15
    rCSI 11.56%
    PRS 89.53
  • fallopian tube secretory epithelial cell CL4030006
    CSI 8.07
    rCSI 7.77%
    PRS 90.03
  • interstitial cell of Cajal CL0002088
    CSI 8.05
    rCSI 10.24%
    PRS 94.5
  • stem cell CL0000034
    CSI 7.49
    rCSI 7.22%
    PRS 87.65
  • renal beta-intercalated cell CL0002201
    CSI 7.3
    rCSI 17.39%
    PRS 91.62
  • bronchus fibroblast of lung CL2000093
    CSI 7.02
    rCSI 5.7%
    PRS 90.83
  • cerebral cortex endothelial cell CL1001602
    CSI 6.95
    rCSI 12.03%
    PRS 86.5
  • cardiac neuron CL0010022
    CSI 6.89
    rCSI 22.04%
    PRS 90.32
  • basal cell CL0000646
    CSI 6.88
    rCSI 9.2%
    PRS 88.96
  • intermediate monocyte CL0002393
    CSI 6.75
    rCSI 10.19%
    PRS 95
  • intestine goblet cell CL0019031
    CSI 6.74
    rCSI 5.98%
    PRS 89.14
  • pancreatic acinar cell CL0002064
    CSI 6.68
    rCSI 8.88%
    PRS 93.91
  • perivascular cell CL4033054
    CSI 6.62
    rCSI 9.05%
    PRS 94.18
  • skin fibroblast CL0002620
    CSI 6.6
    rCSI 5.69%
    PRS 90.96
  • epithelial cell of lower respiratory tract CL0002632
    CSI 6.44
    rCSI 4.99%
    PRS 93.51
  • vascular associated smooth muscle cell CL0000359
    CSI 6.39
    rCSI 20.74%
    PRS 89.79
  • ciliated cell CL0000064
    CSI 6.39
    rCSI 10.35%
    PRS 85.93
  • colon epithelial cell CL0011108
    CSI 6.19
    rCSI 6.48%
    PRS 89.38
  • deuterosomal cell CL4033044
    CSI 5.99
    rCSI 20.25%
    PRS 86.42
  • subcutaneous adipocyte CL0002521
    CSI 5.98
    rCSI 30.62%
    PRS 93.32
  • mononuclear phagocyte CL0000113
    CSI 5.86
    rCSI 12.89%
    PRS 93.62
  • mucous neck cell CL0000651
    CSI 5.81
    rCSI 8.37%
    PRS 93.77
  • cardiac endothelial cell CL0010008
    CSI 5.8
    rCSI 23.41%
    PRS 92.06
  • respiratory goblet cell CL0002370
    CSI 5.74
    rCSI 62.46%
    PRS 93.79
  • basal cell of prostate epithelium CL0002341
    CSI 5.65
    rCSI 16.35%
    PRS 93.5
  • respiratory hillock cell CL4030023
    CSI 5.57
    rCSI 9.93%
    PRS 94.79
  • renal alpha-intercalated cell CL0005011
    CSI 5.56
    rCSI 7.43%
    PRS 94.31
  • tracheobronchial smooth muscle cell CL0019019
    CSI 5.47
    rCSI 9.64%
    PRS 93.88
  • L2/3-6 intratelencephalic projecting glutamatergic neuron CL4023040
    CSI 5.46
    rCSI 13.28%
    PRS 77.35
  • enteric smooth muscle cell CL0002504
    CSI 5.32
    rCSI 7.59%
    PRS 91.53
  • acinar cell CL0000622
    CSI 5.11
    rCSI 7.49%
    PRS 95.76
  • sst GABAergic cortical interneuron CL4023017
    CSI 5.09
    rCSI 6.56%
    PRS 80.58
  • retinal ganglion cell CL0000740
    CSI 5.06
    rCSI 11.18%
    PRS 81.76
  • lung goblet cell CL1000143
    CSI 5.01
    rCSI 55.99%
    PRS 94.88
  • endothelial cell of venule CL1000414
    CSI 4.99
    rCSI 44.23%
    PRS 94.79
  • alveolar type 1 fibroblast cell CL4028004
    CSI 4.98
    rCSI 5.45%
    PRS 93
  • choroid plexus epithelial cell CL0000706
    CSI 4.81
    rCSI 7.88%
    PRS 85.1
  • myoepithelial cell CL0000185
    CSI 4.7
    rCSI 11.9%
    PRS 93.5
  • goblet cell CL0000160
    CSI 4.59
    rCSI 4.34%
    PRS 89.45
  • epithelial cell of lung CL0000082
    CSI 4.58
    rCSI 3.8%
    PRS 92.25
  • neural crest cell CL0011012
    CSI 4.54
    rCSI 3.59%
    PRS 85.08
  • pulmonary ionocyte CL0017000
    CSI 4.49
    rCSI 5.47%
    PRS 94.48
  • smooth muscle cell CL0000192
    CSI 4.38
    rCSI 10.45%
    PRS 85.91
  • M cell of gut CL0000682
    CSI 4.34
    rCSI 4.62%
    PRS 93.44
  • parietal epithelial cell CL1000452
    CSI 4.19
    rCSI 11.2%
    PRS 86.66
  • microcirculation associated smooth muscle cell CL0008035
    CSI 4.01
    rCSI 11.61%
    PRS 90.76
  • CD4-positive, alpha-beta cytotoxic T cell CL0000934
    CSI 3.94
    rCSI 5.42%
    PRS 98.04
  • type EC enteroendocrine cell CL0000577
    CSI 3.88
    rCSI 13.77%
    PRS 92.62
  • kidney connecting tubule epithelial cell CL1000768
    CSI 3.84
    rCSI 9.73%
    PRS 85.89
  • enterocyte of epithelium of large intestine CL0002071
    CSI 3.82
    rCSI 20.07%
    PRS 93.03
  • parietal cell CL0000162
    CSI 0.6
    rCSI 5.5%
    PRS 95.1%
  • cardiac blood vessel endothelial cell CL0010006
    CSI 0.7
    rCSI 5.2%
    PRS 85.7%
  • direct pathway medium spiny neuron CL4023026
    CSI 0.8
    rCSI 18.0%
    PRS 77.2%
  • GABAergic amacrine cell CL4030027
    CSI 0.8
    rCSI 2.9%
    PRS 79.7%
  • regular atrial cardiac myocyte CL0002129
    CSI 1.0
    rCSI 3.1%
    PRS 88.2%
  • smooth muscle cell of prostate CL1000487
    CSI 1.0
    rCSI 5.9%
    PRS 94.3%
  • effector memory CD8-positive, alpha-beta T cell, terminally differentiated CL0001062
    CSI 1.1
    rCSI 5.3%
    PRS 97.4%
  • colon goblet cell CL0009039
    CSI 1.1
    rCSI 2.6%
    PRS 93.0%
  • kidney distal convoluted tubule epithelial cell CL1000849
    CSI 1.1
    rCSI 12.0%
    PRS 88.0%
  • mammary gland epithelial cell CL0002327
    CSI 1.1
    rCSI 4.0%
    PRS 95.0%
  • H2 horizontal cell CL0004218
    CSI 1.2
    rCSI 5.9%
    PRS 86.5%
  • stratified epithelial cell CL0000079
    CSI 1.2
    rCSI 7.6%
    PRS 93.9%
  • mesenchymal stem cell CL0000134
    CSI 1.3
    rCSI 13.9%
    PRS 93.2%
  • indirect pathway medium spiny neuron CL4023029
    CSI 1.3
    rCSI 31.2%
    PRS 77.4%
  • endothelial cell of arteriole CL1000412
    CSI 1.5
    rCSI 8.1%
    PRS 96.1%
  • corticothalamic-projecting glutamatergic cortical neuron CL4023013
    CSI 1.5
    rCSI 8.7%
    PRS 79.9%
  • paneth cell CL0000510
    CSI 1.5
    rCSI 2.3%
    PRS 95.9%
  • erythroblast CL0000765
    CSI 1.6
    rCSI 4.3%
    PRS 92.2%
  • luminal cell of prostate epithelium CL0002340
    CSI 1.6
    rCSI 8.8%
    PRS 94.8%
  • tendon cell CL0000388
    CSI 1.7
    rCSI 4.3%
    PRS 93.9%
  • blood vessel smooth muscle cell CL0019018
    CSI 1.7
    rCSI 13.5%
    PRS 89.2%
  • keratocyte CL0002363
    CSI 1.7
    rCSI 4.2%
    PRS 92.5%
  • smooth muscle cell of the pulmonary artery CL0002591
    CSI 1.8
    rCSI 13.8%
    PRS 92.1%
  • lung ciliated cell CL1000271
    CSI 1.8
    rCSI 2.1%
    PRS 86.4%
  • lamp5 GABAergic cortical interneuron CL4023011
    CSI 1.9
    rCSI 3.1%
    PRS 79.5%
  • enteroendocrine cell CL0000164
    CSI 1.9
    rCSI 2.6%
    PRS 89.8%
  • ciliated columnar cell of tracheobronchial tree CL0002145
    CSI 2.0
    rCSI 4.6%
    PRS 84.9%
  • hepatocyte CL0000182
    CSI 2.0
    rCSI 3.6%
    PRS 90.1%
  • L5 extratelencephalic projecting glutamatergic cortical neuron CL4023041
    CSI 2.0
    rCSI 7.3%
    PRS 77.6%
  • lung secretory cell CL1000272
    CSI 2.1
    rCSI 5.1%
    PRS 92.1%
  • lung microvascular endothelial cell CL2000016
    CSI 2.1
    rCSI 40.0%
    PRS 95.0%
  • renal principal cell CL0005009
    CSI 2.1
    rCSI 5.5%
    PRS 90.9%
  • chandelier pvalb GABAergic cortical interneuron CL4023036
    CSI 2.2
    rCSI 6.9%
    PRS 82.5%
  • endothelial cell of vascular tree CL0002139
    CSI 2.2
    rCSI 12.2%
    PRS 87.7%
  • uterine smooth muscle cell CL0002601
    CSI 2.2
    rCSI 14.7%
    PRS 93.6%
  • VIP GABAergic cortical interneuron CL4023016
    CSI 2.4
    rCSI 2.8%
    PRS 79.5%
  • prostate gland microvascular endothelial cell CL2000059
    CSI 2.4
    rCSI 58.1%
    PRS 94.2%
  • epicardial adipocyte CL1000309
    CSI 2.4
    rCSI 7.9%
    PRS 89.1%
  • caudal ganglionic eminence derived cortical interneuron CL4023064
    CSI 2.5
    rCSI 4.4%
    PRS 78.9%
  • adventitial cell CL0002503
    CSI 2.5
    rCSI 5.9%
    PRS 93.4%
  • retinal pigment epithelial cell CL0002586
    CSI 2.7
    rCSI 5.3%
    PRS 88.3%
  • mesenchymal cell CL0008019
    CSI 2.7
    rCSI 6.9%
    PRS 86.9%
  • Bergmann glial cell CL0000644
    CSI 2.8
    rCSI 3.8%
    PRS 84.5%
  • stromal cell CL0000499
    CSI 2.8
    rCSI 7.9%
    PRS 88.0%
  • pancreatic epsilon cell CL0005019
    CSI 2.8
    rCSI 13.2%
    PRS 94.4%
  • ciliated epithelial cell CL0000067
    CSI 2.9
    rCSI 2.6%
    PRS 83.3%
  • vasa recta ascending limb cell CL1001131
    CSI 2.9
    rCSI 13.2%
    PRS 94.4%
  • renal interstitial pericyte CL1001318
    CSI 2.9
    rCSI 8.1%
    PRS 89.1%
  • enteroglial cell CL4040002
    CSI 3.0
    rCSI 15.8%
    PRS 91.3%
  • near-projecting glutamatergic cortical neuron CL4023012
    CSI 3.0
    rCSI 11.4%
    PRS 79.7%
  • Mueller cell CL0000636
    CSI 3.1
    rCSI 7.0%
    PRS 85.5%
  • pancreatic stellate cell CL0002410
    CSI 3.2
    rCSI 18.6%
    PRS 92.8%
  • fibroblast of cardiac tissue CL0002548
    CSI 3.2
    rCSI 15.4%
    PRS 92.4%
  • kidney loop of Henle thin ascending limb epithelial cell CL1001107
    CSI 3.3
    rCSI 8.5%
    PRS 89.1%
  • activated type II NK T cell CL0000931
    CSI 3.3
    rCSI 3.7%
    PRS 97.3%
  • interneuron CL0000099
    CSI 3.5
    rCSI 7.0%
    PRS 85.8%
  • endocardial cell CL0002350
    CSI 3.5
    rCSI 16.8%
    PRS 88.3%
  • L6b glutamatergic cortical neuron CL4023038
    CSI 3.7
    rCSI 11.5%
    PRS 80.8%
  • effector memory CD8-positive, alpha-beta T cell CL0000913
    CSI 3.7
    rCSI 3.4%
    PRS 97.6%
  • enterocyte CL0000584
    CSI 3.7
    rCSI 6.0%
    PRS 88.7%
  • squamous epithelial cell CL0000076
    CSI 3.8
    rCSI 9.0%
    PRS 88.8%
  • glial cell CL0000125
    CSI 3.8
    rCSI 14.5%
    PRS 85.5%
  • mesangial cell CL0000650
    CSI 3.8
    rCSI 15.6%
    PRS 95.4%
  • enterocyte of epithelium of large intestine CL0002071
    CSI 3.8
    rCSI 20.1%
    PRS 93.0%
  • kidney connecting tubule epithelial cell CL1000768
    CSI 3.8
    rCSI 9.7%
    PRS 85.9%
  • type EC enteroendocrine cell CL0000577
    CSI 3.9
    rCSI 13.8%
    PRS 92.6%
  • CD4-positive, alpha-beta cytotoxic T cell CL0000934
    CSI 3.9
    rCSI 5.4%
    PRS 98.0%
  • microcirculation associated smooth muscle cell CL0008035
    CSI 4.0
    rCSI 11.6%
    PRS 90.8%
  • parietal epithelial cell CL1000452
    CSI 4.2
    rCSI 11.2%
    PRS 86.7%
  • M cell of gut CL0000682
    CSI 4.3
    rCSI 4.6%
    PRS 93.4%
  • smooth muscle cell CL0000192
    CSI 4.4
    rCSI 10.5%
    PRS 85.9%
  • pulmonary ionocyte CL0017000
    CSI 4.5
    rCSI 5.5%
    PRS 94.5%
  • neural crest cell CL0011012
    CSI 4.5
    rCSI 3.6%
    PRS 85.1%
  • epithelial cell of lung CL0000082
    CSI 4.6
    rCSI 3.8%
    PRS 92.3%
  • goblet cell CL0000160
    CSI 4.6
    rCSI 4.3%
    PRS 89.5%
  • myoepithelial cell CL0000185
    CSI 4.7
    rCSI 11.9%
    PRS 93.5%
  • choroid plexus epithelial cell CL0000706
    CSI 4.8
    rCSI 7.9%
    PRS 85.1%
  • alveolar type 1 fibroblast cell CL4028004
    CSI 5.0
    rCSI 5.5%
    PRS 93.0%
  • endothelial cell of venule CL1000414
    CSI 5.0
    rCSI 44.2%
    PRS 94.8%
  • lung goblet cell CL1000143
    CSI 5.0
    rCSI 56.0%
    PRS 94.9%
  • retinal ganglion cell CL0000740
    CSI 5.1
    rCSI 11.2%
    PRS 81.8%
  • sst GABAergic cortical interneuron CL4023017
    CSI 5.1
    rCSI 6.6%
    PRS 80.6%
  • acinar cell CL0000622
    CSI 5.1
    rCSI 7.5%
    PRS 95.8%
  • enteric smooth muscle cell CL0002504
    CSI 5.3
    rCSI 7.6%
    PRS 91.5%
  • L2/3-6 intratelencephalic projecting glutamatergic neuron CL4023040
    CSI 5.5
    rCSI 13.3%
    PRS 77.4%
  • tracheobronchial smooth muscle cell CL0019019
    CSI 5.5
    rCSI 9.6%
    PRS 93.9%
  • renal alpha-intercalated cell CL0005011
    CSI 5.6
    rCSI 7.4%
    PRS 94.3%
  • respiratory hillock cell CL4030023
    CSI 5.6
    rCSI 9.9%
    PRS 94.8%
  • basal cell of prostate epithelium CL0002341
    CSI 5.7
    rCSI 16.4%
    PRS 93.5%
  • respiratory goblet cell CL0002370
    CSI 5.7
    rCSI 62.5%
    PRS 93.8%
  • cardiac endothelial cell CL0010008
    CSI 5.8
    rCSI 23.4%
    PRS 92.1%
  • mucous neck cell CL0000651
    CSI 5.8
    rCSI 8.4%
    PRS 93.8%
  • mononuclear phagocyte CL0000113
    CSI 5.9
    rCSI 12.9%
    PRS 93.6%
  • subcutaneous adipocyte CL0002521
    CSI 6.0
    rCSI 30.6%
    PRS 93.3%
  • deuterosomal cell CL4033044
    CSI 6.0
    rCSI 20.3%
    PRS 86.4%
  • colon epithelial cell CL0011108
    CSI 6.2
    rCSI 6.5%
    PRS 89.4%
  • ciliated cell CL0000064
    CSI 6.4
    rCSI 10.4%
    PRS 85.9%
  • vascular associated smooth muscle cell CL0000359
    CSI 6.4
    rCSI 20.7%
    PRS 89.8%
  • epithelial cell of lower respiratory tract CL0002632
    CSI 6.4
    rCSI 5.0%
    PRS 93.5%
  • skin fibroblast CL0002620
    CSI 6.6
    rCSI 5.7%
    PRS 91.0%

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Network Configuration

Explore relationships of the current gene. Select an Interaction Source: 'ONTOLOGY' for shared pathways (GO/Reactome) or 'STRING' for protein-protein interactions. Further refine by selecting context genes and comparing Cell Significance Index (CSI) scores between baseline and target cell types and their specific contexts.

Comma-separated if multiple.
Comma-separated if multiple.

Legend:
  • Query Gene
  • Node Color (Target Cell CSI, relative to current network):
    • Very High
    • High
    • Medium
    • Low
    • Very Low
    • CSI N/A
  • Node Size: Proportional to Target Cell CSI magnitude
  • STRING PPI Edge
  • Shared Pathway Edge (ONTOLOGY)

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Other Information

This section provides additional information about the gene, including a description generated by an AI language model and details about associated proteins.

## Summary [PRSS23](/details-gene/11098), or Serine Protease 23, is a protein-coding gene located on chromosome 11q14.2. Functionally, it is characterized as a serine-type endopeptidase involved in proteolysis and protein metabolism. Expression data indicates that [PRSS23](/details-gene/11098) is a significant marker in several secretory and epithelial cell types, particularly those of the respiratory tract, including [respiratory suprabasal cell](/details-cell/CL4033048), [nasal mucosa goblet cell](/details-cell/CL0002480), and [tracheal goblet cell](/details-cell/CL1000329). Its presence is also notable in various endothelial and pancreatic cell populations, suggesting a role in mucosal homeostasis, vascular biology, and potentially endocrine function. ## Cellular Roles and Expression Landscape The **Overall** expression profile of [PRSS23](/details-gene/11098) highlights its prominent role in epithelial and secretory cells lining mucosal surfaces. It shows the highest significance in cells of the respiratory system, including [respiratory suprabasal cell](/details-cell/CL4033048) (CSI: 48.58), [nasal mucosa goblet cell](/details-cell/CL0002480) (CSI: 32.16), [tracheal goblet cell](/details-cell/CL1000329) (CSI: 30.51), and [club cell](/details-cell/CL0000158) (CSI: 30.29). This pattern suggests a specialized function in airway maintenance, potentially related to mucus production or the regulation of the airway surface liquid. Beyond the respiratory tract, [PRSS23](/details-gene/11098) is also significantly expressed in other secretory and ductal systems, such as the pancreas, specifically in [pancreatic D cell](/details-cell/CL0000173) and [pancreatic ductal cell](/details-cell/CL0002079). Furthermore, its consistent expression in various endothelial cell types, including [pulmonary artery endothelial cell](/details-cell/CL1001568), [endothelial cell of pericentral hepatic sinusoid](/details-cell/CL0019022), and [blood vessel endothelial cell](/details-cell/CL0000071), points towards a potential role in vascular biology. A notable, albeit lower, significance in [effector CD8-positive, alpha-beta T cell](/details-cell/CL0001050) suggests a possible secondary role within the immune system. The localization of the protein to the endoplasmic reticulum lumen and extracellular exosomes is consistent with its function as a secreted protease ([Link](https://pubmed.ncbi.nlm.nih.gov/12975309/)). ## Pathways and Molecular Function Functionally, [PRSS23](/details-gene/11098) is annotated with core enzymatic activities related to protein degradation. The Gene Ontology (GO) terms confirm its role in [Proteolysis](/details-go/GO:0006508) and its specific [Serine-type endopeptidase activity](/details-go/GO:0004252). These functions are contextualized within broader Reactome pathways such as [Metabolism of proteins](/details-reactome/R-HSA-392499) and [Post-translational protein modification](/details-reactome/R-HSA-597592). Of particular interest is its involvement in the [Regulation of insulin-like growth factor (igf) transport and uptake by insulin-like growth factor binding proteins (igfbps)](/details-reactome/R-HSA-381426) pathway. This suggests that [PRSS23](/details-gene/11098) may proteolytically cleave IGFBPs, thereby modulating the local availability and activity of IGFs. This function could be highly relevant in the contexts where it is expressed, such as in pancreatic tissue and at the endothelial interface. Its annotation in [Post-translational protein phosphorylation](/details-reactome/R-HSA-8957275) is supported by research identifying secreted kinases responsible for the extracellular phosphoproteome ([Link](https://doi.org/10.1016/j.cell.2015.05.028)). ## Research Directions The specific expression patterns and annotated functions of [PRSS23](/details-gene/11098) provide a basis for several testable hypotheses regarding its physiological roles. **Proposed Hypotheses:** 1. Given its high expression in respiratory goblet and secretory cells, [PRSS23](/details-gene/11098) may function as a key regulator of mucus viscosity and clearance by proteolytically processing mucin glycoproteins or other components of the airway surface liquid. 2. The co-expression of [PRSS23](/details-gene/11098) in endothelial cells and its annotated role in IGF pathway regulation suggest that it may modulate vascular homeostasis or angiogenesis by controlling the local bioavailability of insulin-like growth factors at the blood vessel wall. 3. Its expression in [effector CD8-positive, alpha-beta T cell](/details-cell/CL0001050) indicates a potential, uncharacterized role in T cell function, such as the processing of cell surface receptors, cytokines, or granzymes, thereby influencing cytotoxic activity or immune signaling. **Experimental Approach:** To test the hypothesis that [PRSS23](/details-gene/11098) regulates mucus properties (Hypothesis 1), an *in vitro* study could be performed using air-liquid interface (ALI) cultures of primary human bronchial epithelial cells. [PRSS23](/details-gene/11098) expression could be silenced using CRISPR-Cas9 or shRNA. The resulting impact on mucus could be evaluated by measuring rheological properties (viscosity and elasticity) of the secreted mucus layer. Furthermore, mass spectrometry or western blot analysis could be used to identify changes in the cleavage patterns of major mucin proteins (e.g., MUC5AC, MUC5B) in the [PRSS23](/details-gene/11098)-deficient cultures compared to controls. **Therapeutic Potential:** As a secreted serine protease, [PRSS23](/details-gene/11098) is a potentially druggable enzyme. If its activity is linked to pathologies characterized by abnormal mucus, such as in chronic obstructive pulmonary disease (COPD) or asthma, it could represent a therapeutic target. **Inhibition** of [PRSS23](/details-gene/11098) activity with specific small molecule inhibitors or neutralizing antibodies could be explored as a strategy to normalize mucus properties and improve mucociliary clearance in such respiratory diseases. Its extracellular location makes it an accessible target for biologic therapies.

Genular Protein ID: 2263884523

Symbol: PRS23_HUMAN

Name: Serine protease 23

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 11230166

Title: Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs.

PubMed ID: 11230166

DOI: 10.1101/gr.gr1547r

PubMed ID: 12975309

Title: The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment.

PubMed ID: 12975309

DOI: 10.1101/gr.1293003

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16554811

Title: Human chromosome 11 DNA sequence and analysis including novel gene identification.

PubMed ID: 16554811

DOI: 10.1038/nature04632

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 26091039

Title: A single kinase generates the majority of the secreted phosphoproteome.

PubMed ID: 26091039

DOI: 10.1016/j.cell.2015.05.028

Sequence Information:

  • Length: 383
  • Mass: 43001
  • Checksum: 46EB6C11ABFD5E8F
  • Sequence:
  • MAGIPGLLFL LFFLLCAVGQ VSPYSAPWKP TWPAYRLPVV LPQSTLNLAK PDFGAEAKLE 
    VSSSCGPQCH KGTPLPTYEE AKQYLSYETL YANGSRTETQ VGIYILSSSG DGAQHRDSGS 
    SGKSRRKRQI YGYDSRFSIF GKDFLLNYPF STSVKLSTGC TGTLVAEKHV LTAAHCIHDG 
    KTYVKGTQKL RVGFLKPKFK DGGRGANDST SAMPEQMKFQ WIRVKRTHVP KGWIKGNAND 
    IGMDYDYALL ELKKPHKRKF MKIGVSPPAK QLPGGRIHFS GYDNDRPGNL VYRFCDVKDE 
    TYDLLYQQCD AQPGASGSGV YVRMWKRQQQ KWERKIIGIF SGHQWVDMNG SPQDFNVAVR 
    ITPLKYAQIC YWIKGNYLDC REG