Details for: CCL23

Gene ID: 6368

Symbol: CCL23

Ensembl ID: ENSG00000274736

Description: C-C motif chemokine ligand 23

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 3.2915
    Cell Significance Index: 201.8000
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 1.4683
    Cell Significance Index: 16.6800
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 1.4426
    Cell Significance Index: 22.3200
  • Cell Name: prostate gland microvascular endothelial cell (CL2000059)
    Fold Change: 1.1515
    Cell Significance Index: 8.2700
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 1.0917
    Cell Significance Index: 207.7500
  • Cell Name: lung microvascular endothelial cell (CL2000016)
    Fold Change: 0.9939
    Cell Significance Index: 8.4100
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.7240
    Cell Significance Index: 71.6200
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.6503
    Cell Significance Index: 13.8500
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.6203
    Cell Significance Index: 100.8900
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.5959
    Cell Significance Index: 538.0200
  • Cell Name: myeloid lineage restricted progenitor cell (CL0000839)
    Fold Change: 0.4717
    Cell Significance Index: 6.6200
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.3886
    Cell Significance Index: 42.2700
  • Cell Name: retinal blood vessel endothelial cell (CL0002585)
    Fold Change: 0.3800
    Cell Significance Index: 4.9100
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.2978
    Cell Significance Index: 17.8800
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: 0.1798
    Cell Significance Index: 2.7100
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 0.1304
    Cell Significance Index: 2.3100
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.0895
    Cell Significance Index: 1.9400
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.0462
    Cell Significance Index: 9.1600
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.0108
    Cell Significance Index: 0.3100
  • Cell Name: endothelial cell of periportal hepatic sinusoid (CL0019021)
    Fold Change: 0.0057
    Cell Significance Index: 0.0200
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.0042
    Cell Significance Index: 0.1900
  • Cell Name: endothelial cell of uterus (CL0009095)
    Fold Change: 0.0016
    Cell Significance Index: 0.0100
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0006
    Cell Significance Index: 0.0200
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.0008
    Cell Significance Index: -0.0200
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0012
    Cell Significance Index: -0.2100
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0036
    Cell Significance Index: -6.7700
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0054
    Cell Significance Index: -0.6900
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0056
    Cell Significance Index: -0.2800
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0068
    Cell Significance Index: -12.5300
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0074
    Cell Significance Index: -0.3000
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.0076
    Cell Significance Index: -0.3300
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0078
    Cell Significance Index: -5.9100
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0081
    Cell Significance Index: -12.4500
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0093
    Cell Significance Index: -12.6000
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.0124
    Cell Significance Index: -0.2100
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0143
    Cell Significance Index: -7.7900
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0158
    Cell Significance Index: -0.4400
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.0162
    Cell Significance Index: -0.4200
  • Cell Name: endothelial cell of hepatic sinusoid (CL1000398)
    Fold Change: -0.0210
    Cell Significance Index: -0.2000
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0257
    Cell Significance Index: -11.6600
  • Cell Name: helper T cell (CL0000912)
    Fold Change: -0.0317
    Cell Significance Index: -0.4500
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0358
    Cell Significance Index: -4.4000
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0358
    Cell Significance Index: -7.1900
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.0377
    Cell Significance Index: -1.3200
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.0387
    Cell Significance Index: -1.2400
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.0394
    Cell Significance Index: -1.2900
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.0410
    Cell Significance Index: -0.8500
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0480
    Cell Significance Index: -6.9800
  • Cell Name: PP cell (CL0000696)
    Fold Change: -0.0482
    Cell Significance Index: -0.4900
  • Cell Name: late promyelocyte (CL0002151)
    Fold Change: -0.0497
    Cell Significance Index: -0.3300
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0583
    Cell Significance Index: -8.0100
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.0604
    Cell Significance Index: -1.2600
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0690
    Cell Significance Index: -7.0500
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0701
    Cell Significance Index: -8.0400
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -0.0752
    Cell Significance Index: -1.3000
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0781
    Cell Significance Index: -9.1000
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0861
    Cell Significance Index: -11.1200
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: -0.0898
    Cell Significance Index: -0.9300
  • Cell Name: myoepithelial cell (CL0000185)
    Fold Change: -0.1031
    Cell Significance Index: -1.1700
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.1093
    Cell Significance Index: -7.0500
  • Cell Name: neural progenitor cell (CL0011020)
    Fold Change: -0.1102
    Cell Significance Index: -1.0900
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: -0.1133
    Cell Significance Index: -1.4300
  • Cell Name: enteric smooth muscle cell (CL0002504)
    Fold Change: -0.1141
    Cell Significance Index: -0.6000
  • Cell Name: endothelial cell of sinusoid (CL0002262)
    Fold Change: -0.1146
    Cell Significance Index: -0.8400
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.1393
    Cell Significance Index: -10.6900
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.1476
    Cell Significance Index: -11.0000
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: -0.1481
    Cell Significance Index: -2.1500
  • Cell Name: endothelial cell of pericentral hepatic sinusoid (CL0019022)
    Fold Change: -0.1526
    Cell Significance Index: -1.2100
  • Cell Name: Schwann cell precursor (CL0002375)
    Fold Change: -0.1637
    Cell Significance Index: -1.3000
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.1706
    Cell Significance Index: -8.8600
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.1711
    Cell Significance Index: -7.5700
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: -0.1816
    Cell Significance Index: -1.6000
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.1902
    Cell Significance Index: -8.8700
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.1996
    Cell Significance Index: -7.5600
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.2089
    Cell Significance Index: -7.2600
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.2129
    Cell Significance Index: -10.0100
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.2336
    Cell Significance Index: -7.4400
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: -0.2355
    Cell Significance Index: -3.3800
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: -0.2388
    Cell Significance Index: -3.2800
  • Cell Name: decidual cell (CL2000002)
    Fold Change: -0.2440
    Cell Significance Index: -3.9200
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.2445
    Cell Significance Index: -6.5400
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: -0.2459
    Cell Significance Index: -2.0100
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.2468
    Cell Significance Index: -7.2700
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.2514
    Cell Significance Index: -9.2300
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.2562
    Cell Significance Index: -6.3900
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.2685
    Cell Significance Index: -6.8600
  • Cell Name: blood vessel endothelial cell (CL0000071)
    Fold Change: -0.2688
    Cell Significance Index: -2.9200
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -0.2856
    Cell Significance Index: -4.2800
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: -0.2928
    Cell Significance Index: -3.7100
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: -0.3002
    Cell Significance Index: -3.6900
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: -0.3015
    Cell Significance Index: -3.7300
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.3049
    Cell Significance Index: -8.1400
  • Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
    Fold Change: -0.3099
    Cell Significance Index: -6.1800
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: -0.3124
    Cell Significance Index: -7.7900
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.3149
    Cell Significance Index: -8.5700
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.3182
    Cell Significance Index: -6.2100
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.3183
    Cell Significance Index: -8.1100
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: -0.3280
    Cell Significance Index: -4.2900
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.3291
    Cell Significance Index: -7.1100
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.3292
    Cell Significance Index: -6.6100

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** CCL23 is a small, secreted protein that belongs to the C-C chemokine family. It is composed of four conserved cysteine residues and is known for its ability to bind to the CCR1 and CCR3 chemokine receptors. CCL23 has a high affinity for its receptors, which allows it to mediate potent chemotactic and pro-inflammatory effects. The gene is highly expressed in tissues that are involved in the immune response, such as the colon, small intestine, and fallopian tube. **Pathways and Functions** CCL23 is involved in several signaling pathways that regulate immune responses, inflammation, and cell migration. Some of the key pathways and functions of CCL23 include: 1. **Chemotaxis**: CCL23 induces the migration of immune cells, such as eosinophils, monocytes, and lymphocytes, to sites of inflammation. 2. **Inflammation**: CCL23 promotes the recruitment of immune cells to sites of inflammation, which can lead to the activation of immune responses and the production of pro-inflammatory cytokines. 3. **Cell proliferation**: CCL23 regulates the proliferation of immune cells, such as lymphocytes and monocytes, which is essential for the maintenance of immune homeostasis. 4. **Signal transduction**: CCL23 mediates signal transduction events through its interaction with chemokine receptors, which can activate various downstream signaling pathways. **Clinical Significance** CCL23 has been implicated in several diseases, including: 1. **Allergic diseases**: CCL23 has been shown to play a role in the pathogenesis of allergic diseases, such as asthma and atopic dermatitis, by recruiting eosinophils to the airways and skin. 2. **Inflammatory bowel disease**: CCL23 has been implicated in the pathogenesis of inflammatory bowel disease (IBD), such as Crohn's disease and ulcerative colitis, by promoting the recruitment of immune cells to the colon. 3. **Cancer**: CCL23 has been shown to be overexpressed in certain types of cancer, such as colorectal cancer, and may play a role in tumor progression and metastasis. 4. **Autoimmune diseases**: CCL23 has been implicated in the pathogenesis of autoimmune diseases, such as multiple sclerosis and rheumatoid arthritis, by promoting the recruitment of immune cells to sites of inflammation. In conclusion, CCL23 is a critical regulator of immune responses, inflammation, and cell migration, and its dysregulation has been implicated in several diseases. Further studies are needed to fully understand the role of CCL23 in human disease and to identify potential therapeutic targets for the treatment of these diseases.

Genular Protein ID: 753927591

Symbol: CCL23_HUMAN

Name: C-C motif chemokine 23

UniProtKB Accession Codes:

P55773 B7ZKQ3 O00174 O75950 Q52LD4

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 1 CTD 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 9 Ensembl 4 EvolutionaryTrace 1 ExpressionAtlas 1 GO 19 Gene3D 1 GeneCards 1 GeneTree 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 1 PDBsum 1 PRO 1 PROSITE 1 PathwayCommons 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 RNAct 1 Reactome 3 RefSeq 2 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 neXtProt 1

Citations:

PubMed ID: 9104803

Title: Molecular and functional characterization of two novel human C-C chemokines as inhibitors of two distinct classes of myeloid progenitors.

PubMed ID: 9104803

DOI: 10.1084/jem.185.7.1163

PubMed ID: 9558365

Title: Characterization of CKbeta8 and CKbeta8-1: two alternatively spliced forms of human beta-chemokine, chemoattractants for neutrophils, monocytes, and lymphocytes, and potent agonists at CC chemokine receptor 1.

PubMed ID: 9558365

PubMed ID: 10213461

Title: Organization of the chemokine gene cluster on human chromosome 17q11.2 containing the genes for CC chemokine MPIF-1, HCC-2, LEC, and RANTES.

PubMed ID: 10213461

DOI: 10.1089/107999099314153

PubMed ID: 16625196

Title: DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage.

PubMed ID: 16625196

DOI: 10.1038/nature04689

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9129202

Title: The chemokine information source: identification and characterization of novel chemokines using the WorldWideWeb and expressed sequence tag databases.

PubMed ID: 9129202

DOI: 10.1002/jlb.61.5.545

PubMed ID: 15905581

Title: Proteolytic activation of alternative CCR1 ligands in inflammation.

PubMed ID: 15905581

DOI: 10.4049/jimmunol.174.11.7341

PubMed ID: 11060285

Title: Solution structure and dynamics of myeloid progenitor inhibitory factor-1 (MPIF-1), a novel monomeric CC chemokine.

PubMed ID: 11060285

DOI: 10.1074/jbc.m005085200

Sequence Information:

  • Length: 120
  • Mass: 13443
  • Checksum: 6CA622DD3A4B27AD
  • Sequence:
    • MKVSVAALSC LMLVTALGSQ ARVTKDAETE FMMSKLPLEN PVLLDRFHAT SADCCISYTP 
RSIPCSLLES YFETNSECSK PGVIFLTKKG RRFCANPSDK QVQVCMRMLK LDTRIKTRKN

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.