Details for: IGFBP7

Gene ID: 3490

Symbol: IGFBP7

Ensembl ID: ENSG00000163453

Description: insulin like growth factor binding protein 7

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: renal interstitial pericyte (CL1001318)
    Fold Change: 5.86
    Marker Score: 5590
  • Cell Name: contractile cell (CL0000183)
    Fold Change: 5.7
    Marker Score: 3091
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: 5.39
    Marker Score: 3547
  • Cell Name: early promyelocyte (CL0002154)
    Fold Change: 4.73
    Marker Score: 3785.5
  • Cell Name: cardiac neuron (CL0010022)
    Fold Change: 4.53
    Marker Score: 5642
  • Cell Name: kidney collecting duct principal cell (CL1001431)
    Fold Change: 4.49
    Marker Score: 11323
  • Cell Name: epithelial cell of lower respiratory tract (CL0002632)
    Fold Change: 4.43
    Marker Score: 18458.5
  • Cell Name: kidney interstitial cell (CL1000500)
    Fold Change: 4.42
    Marker Score: 3145
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: 4.28
    Marker Score: 11470
  • Cell Name: fibroblast of connective tissue of nonglandular part of prostate (CL1000304)
    Fold Change: 4.25
    Marker Score: 3623
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: 4.15
    Marker Score: 4401
  • Cell Name: kidney interstitial fibroblast (CL1000692)
    Fold Change: 4.1
    Marker Score: 7894
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: 3.93
    Marker Score: 5713
  • Cell Name: supporting cell (CL0000630)
    Fold Change: 3.81
    Marker Score: 7150.5
  • Cell Name: uterine smooth muscle cell (CL0002601)
    Fold Change: 3.8
    Marker Score: 4954.5
  • Cell Name: theca cell (CL0000503)
    Fold Change: 3.74
    Marker Score: 2680
  • Cell Name: bronchus fibroblast of lung (CL2000093)
    Fold Change: 3.69
    Marker Score: 5072
  • Cell Name: endothelial cell of uterus (CL0009095)
    Fold Change: 3.59
    Marker Score: 7167
  • Cell Name: fibroblast of connective tissue of glandular part of prostate (CL1000305)
    Fold Change: 3.54
    Marker Score: 1474
  • Cell Name: fibroblast of lung (CL0002553)
    Fold Change: 3.52
    Marker Score: 9206
  • Cell Name: kidney collecting duct intercalated cell (CL1001432)
    Fold Change: 3.49
    Marker Score: 5794
  • Cell Name: pulmonary artery endothelial cell (CL1001568)
    Fold Change: 3.46
    Marker Score: 2978
  • Cell Name: renal intercalated cell (CL0005010)
    Fold Change: 3.44
    Marker Score: 1836
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 3.4
    Marker Score: 115622.5
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 3.38
    Marker Score: 7429
  • Cell Name: kidney connecting tubule epithelial cell (CL1000768)
    Fold Change: 3.36
    Marker Score: 4753
  • Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
    Fold Change: 3.26
    Marker Score: 28347
  • Cell Name: fibroblast (CL0000057)
    Fold Change: 3.24
    Marker Score: 3133
  • Cell Name: peritubular capillary endothelial cell (CL1001033)
    Fold Change: 3.19
    Marker Score: 742.5
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 3.15
    Marker Score: 5328
  • Cell Name: inflammatory cell (CL0009002)
    Fold Change: 3.09
    Marker Score: 1327
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: 3.08
    Marker Score: 10954
  • Cell Name: pericyte (CL0000669)
    Fold Change: 3.02
    Marker Score: 1766
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 2.95
    Marker Score: 12735
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 2.95
    Marker Score: 2989
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 2.94
    Marker Score: 2631
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 2.92
    Marker Score: 32843.5
  • Cell Name: decidual natural killer cell, human (CL0002343)
    Fold Change: 2.89
    Marker Score: 7985.5
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: 2.89
    Marker Score: 3326
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: 2.89
    Marker Score: 912
  • Cell Name: type I pneumocyte (CL0002062)
    Fold Change: 2.88
    Marker Score: 3471.5
  • Cell Name: late promyelocyte (CL0002151)
    Fold Change: 2.88
    Marker Score: 721
  • Cell Name: alveolar capillary type 2 endothelial cell (CL4028003)
    Fold Change: 2.77
    Marker Score: 4011
  • Cell Name: alveolar capillary type 1 endothelial cell (CL4028002)
    Fold Change: 2.77
    Marker Score: 7035
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: 2.76
    Marker Score: 1396
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: 2.76
    Marker Score: 1813
  • Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
    Fold Change: 2.71
    Marker Score: 2919
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: 2.69
    Marker Score: 60104.5
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 2.67
    Marker Score: 27099
  • Cell Name: myofibroblast cell (CL0000186)
    Fold Change: 2.67
    Marker Score: 3296
  • Cell Name: prostate gland microvascular endothelial cell (CL2000059)
    Fold Change: 2.64
    Marker Score: 1024
  • Cell Name: muscle cell (CL0000187)
    Fold Change: 2.59
    Marker Score: 732
  • Cell Name: NKp46-positive innate lymphoid cell, human (CL0001076)
    Fold Change: 2.57
    Marker Score: 7505
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 2.55
    Marker Score: 1522
  • Cell Name: fibroblast of connective tissue of prostate (CL1000299)
    Fold Change: 2.54
    Marker Score: 633
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: 2.54
    Marker Score: 10394
  • Cell Name: prostate stromal cell (CL0002622)
    Fold Change: 2.52
    Marker Score: 633
  • Cell Name: pancreatic stellate cell (CL0002410)
    Fold Change: 2.48
    Marker Score: 1565.5
  • Cell Name: fibroblast of breast (CL4006000)
    Fold Change: 2.43
    Marker Score: 1389
  • Cell Name: stromal cell of lamina propria of small intestine (CL0009022)
    Fold Change: 2.43
    Marker Score: 547
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 2.42
    Marker Score: 51745
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 2.38
    Marker Score: 1256
  • Cell Name: renal principal cell (CL0005009)
    Fold Change: 2.38
    Marker Score: 1837
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 2.38
    Marker Score: 2878
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 2.36
    Marker Score: 9895
  • Cell Name: parietal epithelial cell (CL1000452)
    Fold Change: 2.33
    Marker Score: 847
  • Cell Name: smooth muscle cell of prostate (CL1000487)
    Fold Change: 2.33
    Marker Score: 593
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: 2.3
    Marker Score: 7906
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: 2.28
    Marker Score: 1176
  • Cell Name: tracheobronchial smooth muscle cell (CL0019019)
    Fold Change: 2.28
    Marker Score: 667
  • Cell Name: endothelial cell of lymphatic vessel (CL0002138)
    Fold Change: 2.27
    Marker Score: 1413.5
  • Cell Name: type EC enteroendocrine cell (CL0000577)
    Fold Change: 2.26
    Marker Score: 2124
  • Cell Name: endothelial cell of hepatic sinusoid (CL1000398)
    Fold Change: 2.25
    Marker Score: 492
  • Cell Name: capillary endothelial cell (CL0002144)
    Fold Change: 2.23
    Marker Score: 2399
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: 2.23
    Marker Score: 1480
  • Cell Name: multi-ciliated epithelial cell (CL0005012)
    Fold Change: 2.21
    Marker Score: 4209
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 2.21
    Marker Score: 508
  • Cell Name: skin fibroblast (CL0002620)
    Fold Change: 2.19
    Marker Score: 568
  • Cell Name: glandular epithelial cell (CL0000150)
    Fold Change: 2.13
    Marker Score: 5224
  • Cell Name: vein endothelial cell (CL0002543)
    Fold Change: 2.12
    Marker Score: 1917.5
  • Cell Name: lung microvascular endothelial cell (CL2000016)
    Fold Change: 2.12
    Marker Score: 451
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 2.11
    Marker Score: 2191
  • Cell Name: blood vessel endothelial cell (CL0000071)
    Fold Change: 2.08
    Marker Score: 2096
  • Cell Name: lung ciliated cell (CL1000271)
    Fold Change: 2.07
    Marker Score: 984.5
  • Cell Name: CD34-positive, CD38-negative hematopoietic stem cell (CL0001024)
    Fold Change: 2.07
    Marker Score: 1498
  • Cell Name: endothelial cell of sinusoid (CL0002262)
    Fold Change: 2.07
    Marker Score: 501
  • Cell Name: alveolar type 2 fibroblast cell (CL4028006)
    Fold Change: 2.06
    Marker Score: 1144
  • Cell Name: smooth muscle cell of large intestine (CL1000279)
    Fold Change: 2.05
    Marker Score: 777
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: 2.04
    Marker Score: 3349
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 2.02
    Marker Score: 1180
  • Cell Name: endothelial cell of pericentral hepatic sinusoid (CL0019022)
    Fold Change: 2.01
    Marker Score: 2157
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 2.01
    Marker Score: 2708
  • Cell Name: PP cell (CL0000696)
    Fold Change: 1.98
    Marker Score: 445
  • Cell Name: enteric smooth muscle cell (CL0002504)
    Fold Change: 1.94
    Marker Score: 4560
  • Cell Name: basal cell (CL0000646)
    Fold Change: 1.93
    Marker Score: 2495
  • Cell Name: epithelial cell of stratum germinativum of esophagus (CL1000447)
    Fold Change: 1.91
    Marker Score: 461
  • Cell Name: type A enteroendocrine cell (CL0002067)
    Fold Change: 1.91
    Marker Score: 769
  • Cell Name: podocyte (CL0000653)
    Fold Change: 1.9
    Marker Score: 704
  • Cell Name: endothelial cell of artery (CL1000413)
    Fold Change: 1.89
    Marker Score: 783
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 1.88
    Marker Score: 16501

Hover over a box to see details here...

Hover over a box to see details here...

Hover over a box to see details here...

Other Information

**Key characteristics:** * IBP7 is a transmembrane protein with a molecular weight of approximately 130 kDa. * It is a member of the IGFBP family of proteins, which are characterized by a conserved IGF-like domain. * IBP7 is expressed in a wide range of cell types, including endothelial cells, pericytes, skeletal muscle cells, and cancer cells. * It is known to interact with various signaling pathways, including the PI3K/Akt pathway, the MAPK pathway, and the mTOR pathway. * IBP7 has been shown to play a significant role in cell adhesion, migration, proliferation, and differentiation. **Pathways and functions:** * IBP7 is involved in cell adhesion by binding to extracellular matrix proteins and facilitating cell-cell interactions. * It also regulates cell migration by interacting with the PI3K/Akt pathway. * IBP7 is essential for the development and maintenance of the cardiovascular and renal epithelium. * It is also involved in the regulation of tissue homeostasis and cancer growth. **Clinical significance:** * Mutations in the IGFBP7 gene have been linked to various human diseases, including cancer, cardiovascular disease, and diabetes. * Overexpression of IGFBP7 has been observed in cancer cells, where it promotes cell growth, invasion, and metastasis. * Inhibition of IGFBP7 has shown to inhibit cancer cell growth and metastasis. **Additional notes:** * IBP7 is a promising target for cancer therapy, as it can be used to block cancer cell growth and metastasis. * The development of IGFBP7 inhibitors is an active area of research, with the potential to improve cancer treatment outcomes.

Genular Protein ID: 945878770

Symbol: IBP7_HUMAN

Name: Insulin-like growth factor-binding protein 7

UniProtKB Accession Codes:

Q16270 B4E1N2 B7Z9W7 Q07822 Q53YE6 Q9UCA8

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 1 EMBL 10 EPD 1 Ensembl 2 GO 15 Gene3D 3 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HPA 1 InParanoid 1 IntAct 1 InterPro 10 KEGG 1 MANE-Select 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PIR 3 PIRSF 1 PRO 1 PROSITE 3 PROSITE-ProRule 3 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 3 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 Reactome 3 RefSeq 2 SMART 3 SMR 1 STRING 1 SUPFAM 3 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 7694637

Title: Identification and characterization of genes differentially expressed in meningiomas.

PubMed ID: 7694637

PubMed ID: 7980422

Title: Purification and molecular cloning of prostacyclin-stimulating factor from serum-free conditioned medium of human diploid fibroblast cells.

PubMed ID: 7980422

DOI: 10.1042/bj3030591

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15815621

Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.

PubMed ID: 15815621

DOI: 10.1038/nature03466

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8117260

Title: Cell adhesion activity of a 30-kDa major secreted protein from human bladder carcinoma cells.

PubMed ID: 8117260

DOI: 10.1006/bbrc.1994.1149

PubMed ID: 15340161

Title: Signal peptide prediction based on analysis of experimentally verified cleavage sites.

PubMed ID: 15340161

DOI: 10.1110/ps.04682504

PubMed ID: 8939990

Title: Synthesis and characterization of insulin-like growth factor-binding protein (IGFBP)-7. Recombinant human mac25 protein specifically binds IGF-I and -II.

PubMed ID: 8939990

DOI: 10.1074/jbc.271.48.30322

PubMed ID: 11549700

Title: Interaction of IGF-binding protein-related protein 1 with a novel protein, neuroendocrine differentiation factor, results in neuroendocrine differentiation of prostate cancer cells.

PubMed ID: 11549700

DOI: 10.1210/jcem.86.9.7845

PubMed ID: 18772245

Title: Screening of human SNP database identifies recoding sites of A-to-I RNA editing.

PubMed ID: 18772245

DOI: 10.1261/rna.816908

PubMed ID: 21835307

Title: Mutation of IGFBP7 causes upregulation of BRAF/MEK/ERK pathway and familial retinal arterial macroaneurysms.

PubMed ID: 21835307

DOI: 10.1016/j.ajhg.2011.07.010

PubMed ID: 26091039

Title: A single kinase generates the majority of the secreted phosphoproteome.

PubMed ID: 26091039

DOI: 10.1016/j.cell.2015.05.028

Sequence Information:

  • Length: 282
  • Mass: 29130
  • Checksum: 75F96EBC3B444D37
  • Sequence:
    • MERPSLRALL LGAAGLLLLL LPLSSSSSSD TCGPCEPASC PPLPPLGCLL GETRDACGCC 
PMCARGEGEP CGGGGAGRGY CAPGMECVKS RKRRKGKAGA AAGGPGVSGV CVCKSRYPVC 
GSDGTTYPSG CQLRAASQRA ESRGEKAITQ VSKGTCEQGP SIVTPPKDIW NVTGAQVYLS 
CEVIGIPTPV LIWNKVKRGH YGVQRTELLP GDRDNLAIQT RGGPEKHEVT GWVLVSPLSK 
EDAGEYECHA SNSQGQASAS AKITVVDALH EIPVKKGEGA EL

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.