Details for: IGFBP7

Gene ID: 3490

Symbol: IGFBP7

Ensembl ID: ENSG00000163453

Description: insulin like growth factor binding protein 7

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 696.5820
    Cell Significance Index: -108.3500
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 367.2085
    Cell Significance Index: -93.1400
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 292.6586
    Cell Significance Index: -120.5600
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 208.9071
    Cell Significance Index: -84.8700
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 202.6168
    Cell Significance Index: -95.6600
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 182.1786
    Cell Significance Index: -93.7100
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 88.6836
    Cell Significance Index: -84.6700
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 87.8620
    Cell Significance Index: -108.3300
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 33.4691
    Cell Significance Index: -73.2500
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 27.4148
    Cell Significance Index: -108.1800
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 25.5677
    Cell Significance Index: -78.5300
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 20.3505
    Cell Significance Index: 359.6200
  • Cell Name: theca cell (CL0000503)
    Fold Change: 15.6833
    Cell Significance Index: 92.1400
  • Cell Name: prostate gland microvascular endothelial cell (CL2000059)
    Fold Change: 13.4031
    Cell Significance Index: 96.2600
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 12.3948
    Cell Significance Index: 140.8100
  • Cell Name: columnar/cuboidal epithelial cell (CL0000075)
    Fold Change: 12.3427
    Cell Significance Index: 47.2600
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: 9.7188
    Cell Significance Index: 65.8500
  • Cell Name: peg cell (CL4033014)
    Fold Change: 7.1942
    Cell Significance Index: 166.2100
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 6.4583
    Cell Significance Index: 886.9100
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 6.0400
    Cell Significance Index: 173.1400
  • Cell Name: perivascular cell (CL4033054)
    Fold Change: 4.5568
    Cell Significance Index: 21.0400
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 4.4552
    Cell Significance Index: 287.4300
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 4.2349
    Cell Significance Index: 113.2800
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: 3.7142
    Cell Significance Index: 72.4900
  • Cell Name: endothelial cell of uterus (CL0009095)
    Fold Change: 3.5263
    Cell Significance Index: 22.0800
  • Cell Name: endothelial cell of periportal hepatic sinusoid (CL0019021)
    Fold Change: 3.4694
    Cell Significance Index: 12.0700
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 2.2376
    Cell Significance Index: 1640.5900
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: 1.9655
    Cell Significance Index: 16.5100
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 1.8424
    Cell Significance Index: 95.9700
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: 1.8259
    Cell Significance Index: 190.1200
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.7853
    Cell Significance Index: 137.0000
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: 1.4619
    Cell Significance Index: 166.8800
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 1.0236
    Cell Significance Index: 558.9900
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.9792
    Cell Significance Index: 444.4100
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.8245
    Cell Significance Index: 11.8400
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.6685
    Cell Significance Index: 9.6200
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.6027
    Cell Significance Index: 77.2600
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.5415
    Cell Significance Index: 103.0500
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.5022
    Cell Significance Index: 945.5300
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.4936
    Cell Significance Index: 218.2400
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 0.4589
    Cell Significance Index: 7.1000
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.3658
    Cell Significance Index: 330.3300
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.2911
    Cell Significance Index: 448.1600
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.2801
    Cell Significance Index: 55.6000
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.2701
    Cell Significance Index: 498.1100
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.1940
    Cell Significance Index: 123.2200
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.1600
    Cell Significance Index: 217.5700
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: 0.1330
    Cell Significance Index: 6.7200
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.1217
    Cell Significance Index: 21.9400
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: 0.0224
    Cell Significance Index: 0.3300
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0039
    Cell Significance Index: -0.0600
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0245
    Cell Significance Index: -18.1200
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0277
    Cell Significance Index: -3.4000
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0298
    Cell Significance Index: -10.7000
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0491
    Cell Significance Index: -5.0200
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0533
    Cell Significance Index: -40.3700
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0672
    Cell Significance Index: -41.9600
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0735
    Cell Significance Index: -41.4600
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.1079
    Cell Significance Index: -3.7900
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.1145
    Cell Significance Index: -19.5500
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: -0.1486
    Cell Significance Index: -102.8100
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: -0.1702
    Cell Significance Index: -16.8400
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: -0.1839
    Cell Significance Index: -29.9200
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.2067
    Cell Significance Index: -30.0500
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.2250
    Cell Significance Index: -26.2200
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.2364
    Cell Significance Index: -49.8000
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.3159
    Cell Significance Index: -90.8900
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.3386
    Cell Significance Index: -38.7900
  • Cell Name: supporting cell (CL0000630)
    Fold Change: -0.3486
    Cell Significance Index: -1.6100
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.3881
    Cell Significance Index: -50.1500
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.3961
    Cell Significance Index: -10.1200
  • Cell Name: thyroid follicular cell (CL0002258)
    Fold Change: -0.4202
    Cell Significance Index: -4.4600
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.4773
    Cell Significance Index: -12.5500
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.4900
    Cell Significance Index: -38.8100
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.4921
    Cell Significance Index: -98.7100
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: -0.5562
    Cell Significance Index: -60.5000
  • Cell Name: kidney cell (CL1000497)
    Fold Change: -0.5849
    Cell Significance Index: -4.6700
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.6407
    Cell Significance Index: -29.0400
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.6779
    Cell Significance Index: -31.8600
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.6980
    Cell Significance Index: -20.1100
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.7263
    Cell Significance Index: -54.1300
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.8151
    Cell Significance Index: -96.1200
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -0.8755
    Cell Significance Index: -18.7200
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.9069
    Cell Significance Index: -22.6700
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.9284
    Cell Significance Index: -56.9200
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: -0.9301
    Cell Significance Index: -7.1100
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: -1.0380
    Cell Significance Index: -71.7800
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -1.0891
    Cell Significance Index: -66.9400
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -1.1290
    Cell Significance Index: -79.8500
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -1.2980
    Cell Significance Index: -68.1500
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: -1.3466
    Cell Significance Index: -80.8400
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -1.5319
    Cell Significance Index: -62.7700
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -1.6139
    Cell Significance Index: -108.5200
  • Cell Name: kidney interstitial cell (CL1000500)
    Fold Change: -1.7305
    Cell Significance Index: -12.9600
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -1.7334
    Cell Significance Index: -109.2500
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -1.7684
    Cell Significance Index: -82.4500
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: -1.8298
    Cell Significance Index: -16.4900
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -1.9295
    Cell Significance Index: -67.0500
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -1.9526
    Cell Significance Index: -109.5700
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -2.0402
    Cell Significance Index: -105.9800

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** IGFBP7 is a secreted protein that binds to IGFs, modulating their activity and availability for cellular receptors. It is structurally related to other IGFBPs, but its expression and function are distinct from those of IGFBP3, IGFBP4, and IGFBP5. IGFBP7 has been shown to have a high affinity for IGF-1 and IGF-2, but its ability to bind and regulate these growth factors is more pronounced in certain cell types. **Pathways and Functions:** IGFBP7 is involved in various cellular pathways, including: 1. **Cell adhesion**: IGFBP7 has been shown to regulate cell adhesion by interacting with cell surface receptors and modulating the expression of adhesion molecules. 2. **Cellular responses to stimuli**: IGFBP7 is involved in the regulation of cellular responses to various stimuli, including growth factors, cytokines, and stress signals. 3. **Cellular responses to stress**: IGFBP7 has been shown to regulate the expression of genes involved in stress response, including heat shock proteins and antioxidant enzymes. 4. **Regulation of cell growth**: IGFBP7 can modulate cell growth by regulating the expression of growth factors, such as IGF-1 and IGF-2, and by interacting with cell surface receptors. 5. **Regulation of insulin-like growth factor (IGF) transport and uptake**: IGFBP7 is involved in the regulation of IGF transport and uptake by cells, which is critical for maintaining the balance of IGF signaling. **Clinical Significance:** IGFBP7 has been implicated in various disease states, including: 1. **Cancer**: IGFBP7 has been shown to be overexpressed in certain types of cancer, including breast and prostate cancer, and has been associated with tumor progression and metastasis. 2. **Renal disease**: IGFBP7 has been shown to be involved in the regulation of renal function and has been implicated in the pathogenesis of kidney disease. 3. **Neurological disorders**: IGFBP7 has been shown to be involved in the regulation of neuronal function and has been implicated in the pathogenesis of neurological disorders, including Alzheimer's disease and Parkinson's disease. In conclusion, IGFBP7 is a multifaceted protein that plays a critical role in regulating cellular processes, including cell growth, differentiation, and survival. Its involvement in various disease states highlights the importance of IGFBP7 in maintaining tissue homeostasis and preventing disease. Further studies are needed to fully elucidate the functions and clinical significance of IGFBP7.

Genular Protein ID: 945878770

Symbol: IBP7_HUMAN

Name: Insulin-like growth factor-binding protein 7

UniProtKB Accession Codes:

Q16270 B4E1N2 B7Z9W7 Q07822 Q53YE6 Q9UCA8

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 1 EMBL 10 Ensembl 2 GO 15 Gene3D 3 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HPA 1 InParanoid 1 IntAct 1 InterPro 10 KEGG 1 MANE-Select 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PDB 1 PDBsum 1 PIR 3 PIRSF 1 PRO 1 PROSITE 3 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 3 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 Reactome 3 RefSeq 2 SMART 3 SMR 1 STRING 1 SUPFAM 3 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 7694637

Title: Identification and characterization of genes differentially expressed in meningiomas.

PubMed ID: 7694637

PubMed ID: 7980422

Title: Purification and molecular cloning of prostacyclin-stimulating factor from serum-free conditioned medium of human diploid fibroblast cells.

PubMed ID: 7980422

DOI: 10.1042/bj3030591

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15815621

Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.

PubMed ID: 15815621

DOI: 10.1038/nature03466

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8117260

Title: Cell adhesion activity of a 30-kDa major secreted protein from human bladder carcinoma cells.

PubMed ID: 8117260

DOI: 10.1006/bbrc.1994.1149

PubMed ID: 15340161

Title: Signal peptide prediction based on analysis of experimentally verified cleavage sites.

PubMed ID: 15340161

DOI: 10.1110/ps.04682504

PubMed ID: 8939990

Title: Synthesis and characterization of insulin-like growth factor-binding protein (IGFBP)-7. Recombinant human mac25 protein specifically binds IGF-I and -II.

PubMed ID: 8939990

DOI: 10.1074/jbc.271.48.30322

PubMed ID: 11549700

Title: Interaction of IGF-binding protein-related protein 1 with a novel protein, neuroendocrine differentiation factor, results in neuroendocrine differentiation of prostate cancer cells.

PubMed ID: 11549700

DOI: 10.1210/jcem.86.9.7845

PubMed ID: 18772245

Title: Screening of human SNP database identifies recoding sites of A-to-I RNA editing.

PubMed ID: 18772245

DOI: 10.1261/rna.816908

PubMed ID: 21835307

Title: Mutation of IGFBP7 causes upregulation of BRAF/MEK/ERK pathway and familial retinal arterial macroaneurysms.

PubMed ID: 21835307

DOI: 10.1016/j.ajhg.2011.07.010

PubMed ID: 26091039

Title: A single kinase generates the majority of the secreted phosphoproteome.

PubMed ID: 26091039

DOI: 10.1016/j.cell.2015.05.028

PubMed ID: 38218180

Title: Structural insight into CD93 recognition by IGFBP7.

PubMed ID: 38218180

DOI: 10.1016/j.str.2023.12.011

Sequence Information:

  • Length: 282
  • Mass: 29130
  • Checksum: 75F96EBC3B444D37
  • Sequence:
    • MERPSLRALL LGAAGLLLLL LPLSSSSSSD TCGPCEPASC PPLPPLGCLL GETRDACGCC 
PMCARGEGEP CGGGGAGRGY CAPGMECVKS RKRRKGKAGA AAGGPGVSGV CVCKSRYPVC 
GSDGTTYPSG CQLRAASQRA ESRGEKAITQ VSKGTCEQGP SIVTPPKDIW NVTGAQVYLS 
CEVIGIPTPV LIWNKVKRGH YGVQRTELLP GDRDNLAIQT RGGPEKHEVT GWVLVSPLSK 
EDAGEYECHA SNSQGQASAS AKITVVDALH EIPVKKGEGA EL

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.