Details for: IGFBP7

Gene ID: 3490

Symbol: IGFBP7

Ensembl ID: ENSG00000163453

Description: insulin like growth factor binding protein 7

Associated with

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: renal interstitial pericyte (CL1001318)
    Fold Change: 5.86
    Marker Score: 5,590
  • Cell Name: contractile cell (CL0000183)
    Fold Change: 5.7
    Marker Score: 3,091
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: 5.39
    Marker Score: 3,547
  • Cell Name: early promyelocyte (CL0002154)
    Fold Change: 4.73
    Marker Score: 3,786
  • Cell Name: cardiac neuron (CL0010022)
    Fold Change: 4.53
    Marker Score: 5,642
  • Cell Name: kidney collecting duct principal cell (CL1001431)
    Fold Change: 4.49
    Marker Score: 11,323
  • Cell Name: epithelial cell of lower respiratory tract (CL0002632)
    Fold Change: 4.43
    Marker Score: 18,459
  • Cell Name: kidney interstitial cell (CL1000500)
    Fold Change: 4.42
    Marker Score: 3,145
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: 4.28
    Marker Score: 11,470
  • Cell Name: fibroblast of connective tissue of nonglandular part of prostate (CL1000304)
    Fold Change: 4.25
    Marker Score: 3,623
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: 4.15
    Marker Score: 4,401
  • Cell Name: kidney interstitial fibroblast (CL1000692)
    Fold Change: 4.1
    Marker Score: 7,894
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: 3.93
    Marker Score: 5,713
  • Cell Name: supporting cell (CL0000630)
    Fold Change: 3.81
    Marker Score: 7,151
  • Cell Name: uterine smooth muscle cell (CL0002601)
    Fold Change: 3.8
    Marker Score: 4,955
  • Cell Name: theca cell (CL0000503)
    Fold Change: 3.74
    Marker Score: 2,680
  • Cell Name: bronchus fibroblast of lung (CL2000093)
    Fold Change: 3.69
    Marker Score: 5,072
  • Cell Name: endothelial cell of uterus (CL0009095)
    Fold Change: 3.59
    Marker Score: 7,167
  • Cell Name: fibroblast of connective tissue of glandular part of prostate (CL1000305)
    Fold Change: 3.54
    Marker Score: 1,474
  • Cell Name: fibroblast of lung (CL0002553)
    Fold Change: 3.52
    Marker Score: 9,206
  • Cell Name: kidney collecting duct intercalated cell (CL1001432)
    Fold Change: 3.49
    Marker Score: 5,794
  • Cell Name: pulmonary artery endothelial cell (CL1001568)
    Fold Change: 3.46
    Marker Score: 2,978
  • Cell Name: renal intercalated cell (CL0005010)
    Fold Change: 3.44
    Marker Score: 1,836
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 3.4
    Marker Score: 115,623
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 3.38
    Marker Score: 7,429
  • Cell Name: kidney connecting tubule epithelial cell (CL1000768)
    Fold Change: 3.36
    Marker Score: 4,753
  • Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
    Fold Change: 3.26
    Marker Score: 28,347
  • Cell Name: fibroblast (CL0000057)
    Fold Change: 3.24
    Marker Score: 3,133
  • Cell Name: peritubular capillary endothelial cell (CL1001033)
    Fold Change: 3.19
    Marker Score: 743
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 3.15
    Marker Score: 5,328
  • Cell Name: inflammatory cell (CL0009002)
    Fold Change: 3.09
    Marker Score: 1,327
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: 3.08
    Marker Score: 10,954
  • Cell Name: pericyte (CL0000669)
    Fold Change: 3.02
    Marker Score: 1,766
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 2.95
    Marker Score: 12,735
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 2.95
    Marker Score: 2,989
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 2.94
    Marker Score: 2,631
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 2.92
    Marker Score: 32,844
  • Cell Name: decidual natural killer cell, human (CL0002343)
    Fold Change: 2.89
    Marker Score: 7,986
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: 2.89
    Marker Score: 3,326
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: 2.89
    Marker Score: 912
  • Cell Name: type I pneumocyte (CL0002062)
    Fold Change: 2.88
    Marker Score: 3,472
  • Cell Name: late promyelocyte (CL0002151)
    Fold Change: 2.88
    Marker Score: 721
  • Cell Name: alveolar capillary type 2 endothelial cell (CL4028003)
    Fold Change: 2.77
    Marker Score: 4,011
  • Cell Name: alveolar capillary type 1 endothelial cell (CL4028002)
    Fold Change: 2.77
    Marker Score: 7,035
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: 2.76
    Marker Score: 1,396
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: 2.76
    Marker Score: 1,813
  • Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
    Fold Change: 2.71
    Marker Score: 2,919
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: 2.69
    Marker Score: 60,105
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 2.67
    Marker Score: 27,099
  • Cell Name: myofibroblast cell (CL0000186)
    Fold Change: 2.67
    Marker Score: 3,296
  • Cell Name: prostate gland microvascular endothelial cell (CL2000059)
    Fold Change: 2.64
    Marker Score: 1,024
  • Cell Name: muscle cell (CL0000187)
    Fold Change: 2.59
    Marker Score: 732
  • Cell Name: NKp46-positive innate lymphoid cell, human (CL0001076)
    Fold Change: 2.57
    Marker Score: 7,505
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 2.55
    Marker Score: 1,522
  • Cell Name: fibroblast of connective tissue of prostate (CL1000299)
    Fold Change: 2.54
    Marker Score: 633
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: 2.54
    Marker Score: 10,394
  • Cell Name: prostate stromal cell (CL0002622)
    Fold Change: 2.52
    Marker Score: 633
  • Cell Name: pancreatic stellate cell (CL0002410)
    Fold Change: 2.48
    Marker Score: 1,566
  • Cell Name: fibroblast of breast (CL4006000)
    Fold Change: 2.43
    Marker Score: 1,389
  • Cell Name: stromal cell of lamina propria of small intestine (CL0009022)
    Fold Change: 2.43
    Marker Score: 547
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 2.42
    Marker Score: 51,745
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 2.38
    Marker Score: 1,256
  • Cell Name: renal principal cell (CL0005009)
    Fold Change: 2.38
    Marker Score: 1,837
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 2.38
    Marker Score: 2,878
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 2.36
    Marker Score: 9,895
  • Cell Name: parietal epithelial cell (CL1000452)
    Fold Change: 2.33
    Marker Score: 847
  • Cell Name: smooth muscle cell of prostate (CL1000487)
    Fold Change: 2.33
    Marker Score: 593
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: 2.3
    Marker Score: 7,906
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: 2.28
    Marker Score: 1,176
  • Cell Name: tracheobronchial smooth muscle cell (CL0019019)
    Fold Change: 2.28
    Marker Score: 667
  • Cell Name: endothelial cell of lymphatic vessel (CL0002138)
    Fold Change: 2.27
    Marker Score: 1,414
  • Cell Name: type EC enteroendocrine cell (CL0000577)
    Fold Change: 2.26
    Marker Score: 2,124
  • Cell Name: endothelial cell of hepatic sinusoid (CL1000398)
    Fold Change: 2.25
    Marker Score: 492
  • Cell Name: capillary endothelial cell (CL0002144)
    Fold Change: 2.23
    Marker Score: 2,399
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: 2.23
    Marker Score: 1,480
  • Cell Name: multi-ciliated epithelial cell (CL0005012)
    Fold Change: 2.21
    Marker Score: 4,209
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 2.21
    Marker Score: 508
  • Cell Name: skin fibroblast (CL0002620)
    Fold Change: 2.19
    Marker Score: 568
  • Cell Name: glandular epithelial cell (CL0000150)
    Fold Change: 2.13
    Marker Score: 5,224
  • Cell Name: vein endothelial cell (CL0002543)
    Fold Change: 2.12
    Marker Score: 1,918
  • Cell Name: lung microvascular endothelial cell (CL2000016)
    Fold Change: 2.12
    Marker Score: 451
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 2.11
    Marker Score: 2,191
  • Cell Name: blood vessel endothelial cell (CL0000071)
    Fold Change: 2.08
    Marker Score: 2,096
  • Cell Name: lung ciliated cell (CL1000271)
    Fold Change: 2.07
    Marker Score: 985
  • Cell Name: CD34-positive, CD38-negative hematopoietic stem cell (CL0001024)
    Fold Change: 2.07
    Marker Score: 1,498
  • Cell Name: endothelial cell of sinusoid (CL0002262)
    Fold Change: 2.07
    Marker Score: 501
  • Cell Name: alveolar type 2 fibroblast cell (CL4028006)
    Fold Change: 2.06
    Marker Score: 1,144
  • Cell Name: smooth muscle cell of large intestine (CL1000279)
    Fold Change: 2.05
    Marker Score: 777
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: 2.04
    Marker Score: 3,349
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 2.02
    Marker Score: 1,180
  • Cell Name: endothelial cell of pericentral hepatic sinusoid (CL0019022)
    Fold Change: 2.01
    Marker Score: 2,157
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 2.01
    Marker Score: 2,708
  • Cell Name: PP cell (CL0000696)
    Fold Change: 1.98
    Marker Score: 445
  • Cell Name: enteric smooth muscle cell (CL0002504)
    Fold Change: 1.94
    Marker Score: 4,560
  • Cell Name: basal cell (CL0000646)
    Fold Change: 1.93
    Marker Score: 2,495
  • Cell Name: epithelial cell of stratum germinativum of esophagus (CL1000447)
    Fold Change: 1.91
    Marker Score: 461
  • Cell Name: type A enteroendocrine cell (CL0002067)
    Fold Change: 1.91
    Marker Score: 769
  • Cell Name: podocyte (CL0000653)
    Fold Change: 1.9
    Marker Score: 704
  • Cell Name: endothelial cell of artery (CL1000413)
    Fold Change: 1.89
    Marker Score: 783
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 1.88
    Marker Score: 16,501

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** IGFBP7 is a secreted protein that binds to IGFs, modulating their activity and availability for cellular receptors. It is structurally related to other IGFBPs, but its expression and function are distinct from those of IGFBP3, IGFBP4, and IGFBP5. IGFBP7 has been shown to have a high affinity for IGF-1 and IGF-2, but its ability to bind and regulate these growth factors is more pronounced in certain cell types. **Pathways and Functions:** IGFBP7 is involved in various cellular pathways, including: 1. **Cell adhesion**: IGFBP7 has been shown to regulate cell adhesion by interacting with cell surface receptors and modulating the expression of adhesion molecules. 2. **Cellular responses to stimuli**: IGFBP7 is involved in the regulation of cellular responses to various stimuli, including growth factors, cytokines, and stress signals. 3. **Cellular responses to stress**: IGFBP7 has been shown to regulate the expression of genes involved in stress response, including heat shock proteins and antioxidant enzymes. 4. **Regulation of cell growth**: IGFBP7 can modulate cell growth by regulating the expression of growth factors, such as IGF-1 and IGF-2, and by interacting with cell surface receptors. 5. **Regulation of insulin-like growth factor (IGF) transport and uptake**: IGFBP7 is involved in the regulation of IGF transport and uptake by cells, which is critical for maintaining the balance of IGF signaling. **Clinical Significance:** IGFBP7 has been implicated in various disease states, including: 1. **Cancer**: IGFBP7 has been shown to be overexpressed in certain types of cancer, including breast and prostate cancer, and has been associated with tumor progression and metastasis. 2. **Renal disease**: IGFBP7 has been shown to be involved in the regulation of renal function and has been implicated in the pathogenesis of kidney disease. 3. **Neurological disorders**: IGFBP7 has been shown to be involved in the regulation of neuronal function and has been implicated in the pathogenesis of neurological disorders, including Alzheimer's disease and Parkinson's disease. In conclusion, IGFBP7 is a multifaceted protein that plays a critical role in regulating cellular processes, including cell growth, differentiation, and survival. Its involvement in various disease states highlights the importance of IGFBP7 in maintaining tissue homeostasis and preventing disease. Further studies are needed to fully elucidate the functions and clinical significance of IGFBP7.

Genular Protein ID: 945878770

Symbol: IBP7_HUMAN

Name: Insulin-like growth factor-binding protein 7

UniProtKB Accession Codes:

Q16270 B4E1N2 B7Z9W7 Q07822 Q53YE6 Q9UCA8

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 1 EMBL 10 EPD 1 Ensembl 2 GO 15 Gene3D 3 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HPA 1 InParanoid 1 IntAct 1 InterPro 10 KEGG 1 MANE-Select 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PIR 3 PIRSF 1 PRO 1 PROSITE 3 PROSITE-ProRule 3 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 3 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 Reactome 3 RefSeq 2 SMART 3 SMR 1 STRING 1 SUPFAM 3 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 7694637

Title: Identification and characterization of genes differentially expressed in meningiomas.

PubMed ID: 7694637

PubMed ID: 7980422

Title: Purification and molecular cloning of prostacyclin-stimulating factor from serum-free conditioned medium of human diploid fibroblast cells.

PubMed ID: 7980422

DOI: 10.1042/bj3030591

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15815621

Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.

PubMed ID: 15815621

DOI: 10.1038/nature03466

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8117260

Title: Cell adhesion activity of a 30-kDa major secreted protein from human bladder carcinoma cells.

PubMed ID: 8117260

DOI: 10.1006/bbrc.1994.1149

PubMed ID: 15340161

Title: Signal peptide prediction based on analysis of experimentally verified cleavage sites.

PubMed ID: 15340161

DOI: 10.1110/ps.04682504

PubMed ID: 8939990

Title: Synthesis and characterization of insulin-like growth factor-binding protein (IGFBP)-7. Recombinant human mac25 protein specifically binds IGF-I and -II.

PubMed ID: 8939990

DOI: 10.1074/jbc.271.48.30322

PubMed ID: 11549700

Title: Interaction of IGF-binding protein-related protein 1 with a novel protein, neuroendocrine differentiation factor, results in neuroendocrine differentiation of prostate cancer cells.

PubMed ID: 11549700

DOI: 10.1210/jcem.86.9.7845

PubMed ID: 18772245

Title: Screening of human SNP database identifies recoding sites of A-to-I RNA editing.

PubMed ID: 18772245

DOI: 10.1261/rna.816908

PubMed ID: 21835307

Title: Mutation of IGFBP7 causes upregulation of BRAF/MEK/ERK pathway and familial retinal arterial macroaneurysms.

PubMed ID: 21835307

DOI: 10.1016/j.ajhg.2011.07.010

PubMed ID: 26091039

Title: A single kinase generates the majority of the secreted phosphoproteome.

PubMed ID: 26091039

DOI: 10.1016/j.cell.2015.05.028

Sequence Information:

  • Length: 282
  • Mass: 29130
  • Checksum: 75F96EBC3B444D37
  • Sequence:
    • MERPSLRALL LGAAGLLLLL LPLSSSSSSD TCGPCEPASC PPLPPLGCLL GETRDACGCC 
PMCARGEGEP CGGGGAGRGY CAPGMECVKS RKRRKGKAGA AAGGPGVSGV CVCKSRYPVC 
GSDGTTYPSG CQLRAASQRA ESRGEKAITQ VSKGTCEQGP SIVTPPKDIW NVTGAQVYLS 
CEVIGIPTPV LIWNKVKRGH YGVQRTELLP GDRDNLAIQT RGGPEKHEVT GWVLVSPLSK 
EDAGEYECHA SNSQGQASAS AKITVVDALH EIPVKKGEGA EL

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.