Details for: SPARC

Gene ID: 6678

Symbol: SPARC

Ensembl ID: ENSG00000113140

Description: secreted protein acidic and cysteine rich

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 9.23
    Marker Score: 163803
  • Cell Name: endocardial cell (CL0002350)
    Fold Change: 5.36
    Marker Score: 3029
  • Cell Name: alveolar capillary type 1 endothelial cell (CL4028002)
    Fold Change: 4.9
    Marker Score: 12467
  • Cell Name: alveolar capillary type 2 endothelial cell (CL4028003)
    Fold Change: 4.4
    Marker Score: 6373
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: 4.38
    Marker Score: 6740
  • Cell Name: mesodermal cell (CL0000222)
    Fold Change: 4.18
    Marker Score: 55151
  • Cell Name: bronchus fibroblast of lung (CL2000093)
    Fold Change: 3.95
    Marker Score: 5435
  • Cell Name: skeletal muscle satellite cell (CL0000594)
    Fold Change: 3.81
    Marker Score: 2549
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 3.7
    Marker Score: 24039
  • Cell Name: supporting cell (CL0000630)
    Fold Change: 3.5
    Marker Score: 6583
  • Cell Name: uterine smooth muscle cell (CL0002601)
    Fold Change: 3.38
    Marker Score: 4398
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: 3.37
    Marker Score: 19995
  • Cell Name: fibroblast of lung (CL0002553)
    Fold Change: 3.37
    Marker Score: 8810
  • Cell Name: epithelial cell of lower respiratory tract (CL0002632)
    Fold Change: 3.18
    Marker Score: 13271.5
  • Cell Name: theca cell (CL0000503)
    Fold Change: 3.18
    Marker Score: 2278.5
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 3.15
    Marker Score: 35466.5
  • Cell Name: mesothelial cell of epicardium (CL0011019)
    Fold Change: 3.14
    Marker Score: 1007
  • Cell Name: endothelial cell of uterus (CL0009095)
    Fold Change: 3.1
    Marker Score: 6190
  • Cell Name: contractile cell (CL0000183)
    Fold Change: 3.05
    Marker Score: 1651
  • Cell Name: fibroblast of connective tissue of nonglandular part of prostate (CL1000304)
    Fold Change: 2.97
    Marker Score: 2531
  • Cell Name: renal interstitial pericyte (CL1001318)
    Fold Change: 2.91
    Marker Score: 2779
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 2.87
    Marker Score: 12395
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: 2.81
    Marker Score: 4080
  • Cell Name: ovarian surface epithelial cell (CL2000064)
    Fold Change: 2.81
    Marker Score: 7639
  • Cell Name: peritubular capillary endothelial cell (CL1001033)
    Fold Change: 2.8
    Marker Score: 652
  • Cell Name: kidney interstitial cell (CL1000500)
    Fold Change: 2.75
    Marker Score: 1955
  • Cell Name: smooth muscle cell of large intestine (CL1000279)
    Fold Change: 2.68
    Marker Score: 1014
  • Cell Name: myofibroblast cell (CL0000186)
    Fold Change: 2.67
    Marker Score: 3300
  • Cell Name: migratory enteric neural crest cell (CL0002607)
    Fold Change: 2.65
    Marker Score: 2492
  • Cell Name: epicardial adipocyte (CL1000309)
    Fold Change: 2.64
    Marker Score: 1284
  • Cell Name: fibroblast of connective tissue of glandular part of prostate (CL1000305)
    Fold Change: 2.61
    Marker Score: 1087
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 2.6
    Marker Score: 26178
  • Cell Name: neural crest cell (CL0011012)
    Fold Change: 2.54
    Marker Score: 2718
  • Cell Name: Leydig cell (CL0000178)
    Fold Change: 2.5
    Marker Score: 2689
  • Cell Name: chromaffin cell (CL0000166)
    Fold Change: 2.49
    Marker Score: 3497
  • Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
    Fold Change: 2.46
    Marker Score: 1544
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: 2.46
    Marker Score: 5127
  • Cell Name: type EC enteroendocrine cell (CL0000577)
    Fold Change: 2.45
    Marker Score: 2310
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 2.42
    Marker Score: 4101
  • Cell Name: preosteoblast (CL0007010)
    Fold Change: 2.41
    Marker Score: 684
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: 2.37
    Marker Score: 2535
  • Cell Name: enterocyte of colon (CL1000347)
    Fold Change: 2.35
    Marker Score: 3625.5
  • Cell Name: enteric smooth muscle cell (CL0002504)
    Fold Change: 2.35
    Marker Score: 5537
  • Cell Name: pericyte (CL0000669)
    Fold Change: 2.33
    Marker Score: 1362
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: 2.33
    Marker Score: 1534
  • Cell Name: fibroblast (CL0000057)
    Fold Change: 2.32
    Marker Score: 2244
  • Cell Name: cardiac neuron (CL0010022)
    Fold Change: 2.29
    Marker Score: 2848
  • Cell Name: stromal cell of lamina propria of small intestine (CL0009022)
    Fold Change: 2.28
    Marker Score: 513
  • Cell Name: prostate gland microvascular endothelial cell (CL2000059)
    Fold Change: 2.25
    Marker Score: 875
  • Cell Name: Unknown (CL0002371)
    Fold Change: 2.22
    Marker Score: 2358
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 2.22
    Marker Score: 75472
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: 2.21
    Marker Score: 2539
  • Cell Name: fat cell (CL0000136)
    Fold Change: 2.2
    Marker Score: 1232
  • Cell Name: pancreatic stellate cell (CL0002410)
    Fold Change: 2.16
    Marker Score: 1363.5
  • Cell Name: endothelial cell of sinusoid (CL0002262)
    Fold Change: 2.11
    Marker Score: 513
  • Cell Name: muscle cell (CL0000187)
    Fold Change: 2.04
    Marker Score: 578
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 2.03
    Marker Score: 467
  • Cell Name: glomerular endothelial cell (CL0002188)
    Fold Change: 2.03
    Marker Score: 515
  • Cell Name: capillary endothelial cell (CL0002144)
    Fold Change: 2.03
    Marker Score: 2180
  • Cell Name: early promyelocyte (CL0002154)
    Fold Change: 2.02
    Marker Score: 1621
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 2.02
    Marker Score: 1347
  • Cell Name: fibroblast of connective tissue of prostate (CL1000299)
    Fold Change: 2
    Marker Score: 498
  • Cell Name: prostate stromal cell (CL0002622)
    Fold Change: 1.98
    Marker Score: 498
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 1.98
    Marker Score: 1774
  • Cell Name: pulmonary artery endothelial cell (CL1001568)
    Fold Change: 1.97
    Marker Score: 1693
  • Cell Name: respiratory epithelial cell (CL0002368)
    Fold Change: 1.97
    Marker Score: 1083
  • Cell Name: tracheobronchial smooth muscle cell (CL0019019)
    Fold Change: 1.93
    Marker Score: 567
  • Cell Name: subcutaneous fat cell (CL0002521)
    Fold Change: 1.91
    Marker Score: 698
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 1.87
    Marker Score: 1119
  • Cell Name: skin fibroblast (CL0002620)
    Fold Change: 1.86
    Marker Score: 483
  • Cell Name: fibroblast of breast (CL4006000)
    Fold Change: 1.86
    Marker Score: 1058.5
  • Cell Name: Bergmann glial cell (CL0000644)
    Fold Change: 1.84
    Marker Score: 749
  • Cell Name: blood vessel endothelial cell (CL0000071)
    Fold Change: 1.8
    Marker Score: 1815
  • Cell Name: kidney interstitial fibroblast (CL1000692)
    Fold Change: 1.8
    Marker Score: 3462
  • Cell Name: vein endothelial cell (CL0002543)
    Fold Change: 1.8
    Marker Score: 1625
  • Cell Name: cell of skeletal muscle (CL0000188)
    Fold Change: 1.8
    Marker Score: 1366
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: 1.77
    Marker Score: 6549
  • Cell Name: smooth muscle cell of prostate (CL1000487)
    Fold Change: 1.74
    Marker Score: 443
  • Cell Name: interstitial cell of Cajal (CL0002088)
    Fold Change: 1.72
    Marker Score: 596
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 1.71
    Marker Score: 713
  • Cell Name: lung microvascular endothelial cell (CL2000016)
    Fold Change: 1.69
    Marker Score: 359
  • Cell Name: epithelial cell of glomerular capsule (CL1000450)
    Fold Change: 1.68
    Marker Score: 429
  • Cell Name: inflammatory cell (CL0009002)
    Fold Change: 1.66
    Marker Score: 716
  • Cell Name: adventitial cell (CL0002503)
    Fold Change: 1.66
    Marker Score: 409
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: 1.65
    Marker Score: 1099
  • Cell Name: retinal blood vessel endothelial cell (CL0002585)
    Fold Change: 1.65
    Marker Score: 397
  • Cell Name: type I pneumocyte (CL0002062)
    Fold Change: 1.62
    Marker Score: 1957
  • Cell Name: glial cell (CL0000125)
    Fold Change: 1.58
    Marker Score: 1738
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 1.57
    Marker Score: 778
  • Cell Name: hepatic stellate cell (CL0000632)
    Fold Change: 1.57
    Marker Score: 593
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: 1.57
    Marker Score: 1309
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.56
    Marker Score: 1134
  • Cell Name: mesenchymal lymphangioblast (CL0005021)
    Fold Change: 1.55
    Marker Score: 347
  • Cell Name: chondrocyte (CL0000138)
    Fold Change: 1.53
    Marker Score: 688
  • Cell Name: thyroid follicular cell (CL0002258)
    Fold Change: 1.51
    Marker Score: 1185
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 1.48
    Marker Score: 5822
  • Cell Name: endothelial cell of artery (CL1000413)
    Fold Change: 1.48
    Marker Score: 611.5
  • Cell Name: mesothelial cell (CL0000077)
    Fold Change: 1.47
    Marker Score: 590
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 1.46
    Marker Score: 1457
  • Cell Name: reticular cell (CL0000432)
    Fold Change: 1.45
    Marker Score: 530

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Other Information

**Key Characteristics:** 1. **Structure:** SPARC is a secreted protein consisting of a cysteine-rich domain and an acidic domain, which confers its ability to bind to various ligands and receptors. 2. **Expression:** SPARC is widely expressed in various cell types, including endothelial cells, mesenchymal stem cells, and fibroblasts, highlighting its involvement in tissue development and maintenance. 3. **Functionality:** SPARC exhibits a range of functions, including cell adhesion, signaling, and regulation of extracellular matrix organization, which are essential for tissue homeostasis and immune response. **Pathways and Functions:** 1. **Cell Adhesion and Signaling:** SPARC interacts with various receptors, including integrins, CD44, and CD147, to regulate cell adhesion, migration, and proliferation. 2. **Extracellular Matrix Organization:** SPARC modulates the organization and structure of the extracellular matrix, influencing cell behavior and tissue development. 3. **Immune System Regulation:** SPARC influences immune cell function, including endothelial cell migration, platelet activation, and regulation of angiogenesis. 4. **Inflammation and Tissue Repair:** SPARC is involved in the regulation of inflammatory responses and tissue repair, highlighting its potential role in disease pathology. **Clinical Significance:** 1. **Cancer:** Alterations in SPARC expression have been linked to cancer progression, metastasis, and poor prognosis, emphasizing its potential as a biomarker and therapeutic target. 2. **Vascular Diseases:** SPARC plays a critical role in vascular health, and its dysregulation has been implicated in atherosclerosis, hypertension, and cardiovascular disease. 3. **Neurological Disorders:** SPARC has been implicated in neurological disorders, such as Alzheimer's disease, Parkinson's disease, and multiple sclerosis, highlighting its potential role in disease pathogenesis. 4. **Wound Healing:** SPARC is involved in wound healing, and its dysregulation can impair tissue repair and regeneration. In conclusion, SPARC is a multifunctional protein that plays a crucial role in various biological processes, including immune system regulation, cellular development, and disease pathology. Further research is necessary to fully elucidate the role of SPARC in human health and disease, but its significance as a biomarker and therapeutic target is already evident.

Genular Protein ID: 586698926

Symbol: SPRC_HUMAN

Name: SPARC

UniProtKB Accession Codes:

P09486 D3DQH9 Q6IBK4

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 2 CPTAC 1 CTD 1 ChEBI 5 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 3 EMBL 20 EPD 1 Ensembl 1 EvolutionaryTrace 1 ExpressionAtlas 1 GO 21 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyConnect 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 IDEAL 1 InParanoid 1 IntAct 1 InterPro 9 KEGG 1 MANE-Select 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 MaxQB 1 MetOSite 1 NCBI Taxonomy 1 OGP 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PDB 7 PDBsum 4 PIR 1 PRO 1 PROSITE 4 PROSITE-ProRule 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 3 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 4 RefSeq 3 SIGNOR 1 SMART 2 SMR 1 STRING 1 SUPFAM 3 SignaLink 1 TCDB 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 3410046

Title: Cloning and complete amino acid sequences of human and murine basement membrane protein BM-40 (SPARC, osteonectin).

PubMed ID: 3410046

DOI: 10.1016/0014-5793(88)80054-1

PubMed ID: 2838412

Title: Molecular analysis of the cDNA for human SPARC/osteonectin/BM-40: sequence, expression, and localization of the gene to chromosome 5q31-q33.

PubMed ID: 2838412

DOI: 10.1016/0888-7543(88)90107-3

PubMed ID: 2790009

Title: Structure of human osteonectin based upon analysis of cDNA and genomic sequences.

PubMed ID: 2790009

DOI: 10.1021/bi00441a049

PubMed ID: 2338025

Title: Structure and expression of osteonectin mRNA in human tissue.

PubMed ID: 2338025

DOI: 10.3109/03008209009152419

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 17974005

Title: The full-ORF clone resource of the German cDNA consortium.

PubMed ID: 17974005

DOI: 10.1186/1471-2164-8-399

PubMed ID: 3597437

Title: Purification and partial characterization of small proteoglycans I and II, bone sialoproteins I and II, and osteonectin from the mineral compartment of developing human bone.

PubMed ID: 3597437

DOI: 10.1016/s0021-9258(18)47991-4

PubMed ID: 2306517

Title: Human platelet osteonectin: release, surface expression, and partial characterization.

PubMed ID: 2306517

PubMed ID: 3400777

Title: Osteonectin/SPARC/BM-40 in human decidua and carcinoma, tissues characterized by de novo formation of basement membrane.

PubMed ID: 3400777

PubMed ID: 7495300

Title: Immunolocalization of SPARC, tenascin, and thrombospondin in pulmonary fibrosis.

PubMed ID: 7495300

PubMed ID: 9457905

Title: BM-40 (osteonectin, SPARC) is expressed both in the epidermal and in the dermal compartment of adult human skin.

PubMed ID: 9457905

DOI: 10.1046/j.1523-1747.1998.00094.x

PubMed ID: 26027498

Title: Recessive osteogenesis imperfecta caused by missense mutations in SPARC.

PubMed ID: 26027498

DOI: 10.1016/j.ajhg.2015.04.021

PubMed ID: 8548457

Title: Structure of a novel extracellular Ca(2+)-binding module in BM-40.

PubMed ID: 8548457

DOI: 10.1038/nsb0196-67

PubMed ID: 9233787

Title: Crystal structure of a pair of follistatin-like and EF-hand calcium-binding domains in BM-40.

PubMed ID: 9233787

DOI: 10.1093/emboj/16.13.3778

PubMed ID: 9501084

Title: Crystal structure and mapping by site-directed mutagenesis of the collagen-binding epitope of an activated form of BM-40/SPARC/osteonectin.

PubMed ID: 9501084

DOI: 10.1093/emboj/17.6.1625

Sequence Information:

  • Length: 303
  • Mass: 34632
  • Checksum: B914599F79705945
  • Sequence:
    • MRAWIFFLLC LAGRALAAPQ QEALPDETEV VEETVAEVTE VSVGANPVQV EVGEFDDGAE 
ETEEEVVAEN PCQNHHCKHG KVCELDENNT PMCVCQDPTS CPAPIGEFEK VCSNDNKTFD 
SSCHFFATKC TLEGTKKGHK LHLDYIGPCK YIPPCLDSEL TEFPLRMRDW LKNVLVTLYE 
RDEDNNLLTE KQKLRVKKIH ENEKRLEAGD HPVELLARDF EKNYNMYIFP VHWQFGQLDQ 
HPIDGYLSHT ELAPLRAPLI PMEHCTTRFF ETCDLDNDKY IALDEWAGCF GIKQKDIDKD 
LVI

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.