Details for: PHLDA2
Gene ID: 7262
Gene Type: Protein-coding - A gene that serves as a template for producing a messenger RNA (mRNA) molecule, which is then translated into a functional protein.
Symbol: PHLDA2
Ensembl ID: ENSG00000181649
Description: pleckstrin homology like domain family A member 2
Selected Context(s): Overall
Cell Significance Landscape
Associated with
Significant Cells
Cell Significance Index (CSI) scores for the chosen context(s)
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CSI 57.45rCSI 71.07%PRS 71.43
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CSI 49.56rCSI 76.58%PRS 73.03
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CSI 37.17rCSI 47.68%PRS 77.58
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CSI 25.44rCSI 21.09%PRS 74.31
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CSI 22.18rCSI 21.39%PRS 66.22
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CSI 21.23rCSI 46.74%PRS 78.11
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CSI 21.03rCSI 60.58%PRS 82.75
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CSI 20.96rCSI 16.25%PRS 77.27
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CSI 20.7rCSI 16.82%PRS 73.79
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CSI 19.97rCSI 21.22%PRS 80.65
-
CSI 19.12rCSI 18.06%PRS 73.14
-
CSI 19.07rCSI 55.16%PRS 82.4
-
CSI 18.85rCSI 54.57%PRS 74.33
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CSI 18.76rCSI 15.72%PRS 77.09
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CSI 18.08rCSI 24.72%PRS 79
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CSI 17.79rCSI 18.63%PRS 71.06
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CSI 17.61rCSI 32%PRS 85.83
-
CSI 16.66rCSI 26.86%PRS 74.43
-
CSI 15.43rCSI 15.99%PRS 78.89
-
CSI 14.3rCSI 21.97%PRS 65.09
-
CSI 13.65rCSI 47.88%PRS 83.47
-
CSI 12.68rCSI 11.26%PRS 71.81
-
CSI 12.48rCSI 26.57%PRS 81.63
-
CSI 11.5rCSI 32.9%PRS 82.49
-
CSI 11.16rCSI 11.14%PRS 67.6
-
CSI 11.1rCSI 16.26%PRS 68.71
-
CSI 11.08rCSI 31.06%PRS 82.51
-
CSI 10.79rCSI 58.02%PRS 82.86
-
CSI 10.29rCSI 20.01%PRS 77.09
-
CSI 10rCSI 17.83%PRS 84.2
-
CSI 9.68rCSI 21.13%PRS 82.86
-
CSI 9.63rCSI 10.04%PRS 73.64
-
CSI 9.44rCSI 19.58%PRS 71.02
-
CSI 9.31rCSI 40.22%PRS 82.96
-
CSI 9rCSI 13.77%PRS 84.18
-
CSI 8.79rCSI 18.97%PRS 82.52
-
CSI 8.75rCSI 12.11%PRS 72.37
-
CSI 8.15rCSI 21.51%PRS 81.89
-
CSI 7.99rCSI 20.65%PRS 68.97
-
CSI 7.68rCSI 11.26%PRS 84.25
-
CSI 7.65rCSI 7.12%PRS 74.71
-
CSI 7.45rCSI 7.17%PRS 73.35
-
CSI 7.06rCSI 14%PRS 81.63
-
CSI 6.86rCSI 10.49%PRS 82.4
-
CSI 6.82rCSI 6.98%PRS 83.98
-
CSI 6.69rCSI 8.94%PRS 73.17
-
CSI 6.46rCSI 7.49%PRS 79.18
-
CSI 6.43rCSI 9.7%PRS 79.23
-
CSI 6.31rCSI 5.82%PRS 75.68
-
CSI 6.3rCSI 7.83%PRS 75.29
-
CSI 6.09rCSI 14.48%PRS 80.85
-
CSI 6.02rCSI 8.22%PRS 74.51
-
CSI 5.9rCSI 8.5%PRS 82.3
-
CSI 5.81rCSI 5.34%PRS 82.63
-
CSI 5.71rCSI 10.8%PRS 87.02
-
CSI 5.66rCSI 12.64%PRS 81.75
-
CSI 5.35rCSI 7.67%PRS 75.77
-
CSI 5.33rCSI 21.29%PRS 84.38
-
CSI 5.3rCSI 30.82%PRS 79.82
-
CSI 5.26rCSI 17.08%PRS 72.55
-
CSI 5.05rCSI 5.41%PRS 74.55
-
CSI 4.93rCSI 53.68%PRS 84.32
-
CSI 4.82rCSI 5.82%PRS 82.42
-
CSI 4.77rCSI 4.19%PRS 62.38
-
CSI 4.7rCSI 7.47%PRS 83.34
-
CSI 4.65rCSI 7.15%PRS 83.12
-
CSI 4.52rCSI 4.72%PRS 89.35
-
CSI 4.1rCSI 4.99%PRS 80.76
-
CSI 4.09rCSI 5.36%PRS 85.78
-
CSI 4.05rCSI 8.02%PRS 85.03
-
CSI 3.93rCSI 6.94%PRS 80.42
-
CSI 3.83rCSI 5.6%PRS 78.81
-
CSI 3.59rCSI 5.68%PRS 75.83
-
CSI 3.5rCSI 2.78%PRS 91.75
-
CSI 3.3rCSI 7.91%PRS 79.73
-
CSI 3.23rCSI 31.71%PRS 85.51
-
CSI 3.17rCSI 4.85%PRS 78.15
-
CSI 3.13rCSI 7.42%PRS 75.49
-
CSI 3.12rCSI 4.77%PRS 74.3
-
CSI 2.84rCSI 2.45%PRS 76.44
-
CSI 2.78rCSI 70.12%PRS 84.12
-
CSI 2.61rCSI 2.73%PRS 71.73
-
CSI 2.55rCSI 14.69%PRS 71.28
-
CSI 2.5rCSI 15.46%PRS 85.15
-
CSI 2.48rCSI 12.21%PRS 83.34
-
CSI 2.47rCSI 4.47%PRS 90.8
-
CSI 2.41rCSI 5.27%PRS 80.26
-
CSI 2.31rCSI 6.22%PRS 79.78
-
CSI 2.2rCSI 2.58%PRS 75.99
-
CSI 2.16rCSI 3.13%PRS 87.6
-
CSI 2rCSI 2.96%PRS 86.05
-
CSI 1.96rCSI 4.84%PRS 73.09
-
CSI 1.92rCSI 5.06%PRS 87.74
-
CSI 1.84rCSI 3.48%PRS 83.14
-
CSI 1.81rCSI 3.41%PRS 83.83
-
CSI 1.72rCSI 1.99%PRS 65.47
-
CSI 1.68rCSI 7.06%PRS 81.5
-
CSI 1.65rCSI 3.63%PRS 83.53
-
CSI 1.63rCSI 10.72%PRS 84.32
-
CSI 1.56rCSI 7.29%PRS 85.34
-
CSI 0.2rCSI 5.2%PRS 85.4%
-
CSI 0.3rCSI 2.1%PRS 86.0%
-
CSI 0.4rCSI 4.6%PRS 92.9%
-
CSI 0.5rCSI 3.2%PRS 87.6%
-
CSI 0.7rCSI 11.9%PRS 87.1%
-
CSI 0.7rCSI 3.0%PRS 84.3%
-
CSI 0.7rCSI 3.9%PRS 81.1%
-
CSI 0.8rCSI 2.9%PRS 79.8%
-
CSI 1.0rCSI 7.0%PRS 82.8%
-
CSI 1.1rCSI 10.4%PRS 83.2%
-
CSI 1.1rCSI 8.6%PRS 67.6%
-
CSI 1.1rCSI 6.4%PRS 82.4%
-
CSI 1.1rCSI 7.7%PRS 81.9%
-
CSI 1.2rCSI 8.7%PRS 84.8%
-
CSI 1.2rCSI 2.5%PRS 87.0%
-
CSI 1.2rCSI 1.8%PRS 86.9%
-
CSI 1.3rCSI 1.8%PRS 80.0%
-
CSI 1.3rCSI 3.5%PRS 75.5%
-
CSI 1.6rCSI 7.3%PRS 85.3%
-
CSI 1.6rCSI 10.7%PRS 84.3%
-
CSI 1.7rCSI 3.6%PRS 83.5%
-
CSI 1.7rCSI 7.1%PRS 81.5%
-
CSI 1.7rCSI 2.0%PRS 65.5%
-
CSI 1.8rCSI 3.4%PRS 83.8%
-
CSI 1.8rCSI 3.5%PRS 83.1%
-
CSI 1.9rCSI 5.1%PRS 87.7%
-
CSI 2.0rCSI 4.8%PRS 73.1%
-
CSI 2.0rCSI 3.0%PRS 86.1%
-
CSI 2.2rCSI 3.1%PRS 87.6%
-
CSI 2.2rCSI 2.6%PRS 76.0%
-
CSI 2.3rCSI 6.2%PRS 79.8%
-
CSI 2.4rCSI 5.3%PRS 80.3%
-
CSI 2.5rCSI 4.5%PRS 90.8%
-
CSI 2.5rCSI 12.2%PRS 83.3%
-
CSI 2.5rCSI 15.5%PRS 85.2%
-
CSI 2.6rCSI 14.7%PRS 71.3%
-
CSI 2.6rCSI 2.7%PRS 71.7%
-
CSI 2.8rCSI 70.1%PRS 84.1%
-
CSI 2.8rCSI 2.5%PRS 76.4%
-
CSI 3.1rCSI 4.8%PRS 74.3%
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CSI 3.1rCSI 7.4%PRS 75.5%
-
CSI 3.2rCSI 4.9%PRS 78.2%
-
CSI 3.2rCSI 31.7%PRS 85.5%
-
CSI 3.3rCSI 7.9%PRS 79.7%
-
CSI 3.5rCSI 2.8%PRS 91.8%
-
CSI 3.6rCSI 5.7%PRS 75.8%
-
CSI 3.8rCSI 5.6%PRS 78.8%
-
CSI 3.9rCSI 6.9%PRS 80.4%
-
CSI 4.1rCSI 8.0%PRS 85.0%
-
CSI 4.1rCSI 5.4%PRS 85.8%
-
CSI 4.1rCSI 5.0%PRS 80.8%
-
CSI 4.5rCSI 4.7%PRS 89.4%
-
CSI 4.7rCSI 7.2%PRS 83.1%
-
CSI 4.7rCSI 7.5%PRS 83.3%
-
CSI 4.8rCSI 4.2%PRS 62.4%
-
CSI 4.8rCSI 5.8%PRS 82.4%
-
CSI 4.9rCSI 53.7%PRS 84.3%
-
CSI 5.1rCSI 5.4%PRS 74.6%
-
CSI 5.3rCSI 17.1%PRS 72.6%
-
CSI 5.3rCSI 30.8%PRS 79.8%
-
CSI 5.3rCSI 21.3%PRS 84.4%
-
CSI 5.4rCSI 7.7%PRS 75.8%
-
CSI 5.7rCSI 12.6%PRS 81.8%
-
CSI 5.7rCSI 10.8%PRS 87.0%
-
CSI 5.8rCSI 5.3%PRS 82.6%
-
CSI 5.9rCSI 8.5%PRS 82.3%
-
CSI 6.0rCSI 8.2%PRS 74.5%
-
CSI 6.1rCSI 14.5%PRS 80.9%
-
CSI 6.3rCSI 7.8%PRS 75.3%
-
CSI 6.3rCSI 5.8%PRS 75.7%
-
CSI 6.4rCSI 9.7%PRS 79.2%
-
CSI 6.5rCSI 7.5%PRS 79.2%
-
CSI 6.7rCSI 8.9%PRS 73.2%
-
CSI 6.8rCSI 7.0%PRS 84.0%
-
CSI 6.9rCSI 10.5%PRS 82.4%
-
CSI 7.1rCSI 14.0%PRS 81.6%
-
CSI 7.5rCSI 7.2%PRS 73.4%
-
CSI 7.7rCSI 7.1%PRS 74.7%
-
CSI 7.7rCSI 11.3%PRS 84.3%
-
CSI 8.0rCSI 20.7%PRS 69.0%
-
CSI 8.2rCSI 21.5%PRS 81.9%
-
CSI 8.8rCSI 12.1%PRS 72.4%
-
CSI 8.8rCSI 19.0%PRS 82.5%
-
CSI 9.0rCSI 13.8%PRS 84.2%
-
CSI 9.3rCSI 40.2%PRS 83.0%
-
CSI 9.4rCSI 19.6%PRS 71.0%
-
CSI 9.6rCSI 10.0%PRS 73.6%
-
CSI 9.7rCSI 21.1%PRS 82.9%
-
CSI 10.0rCSI 17.8%PRS 84.2%
-
CSI 10.3rCSI 20.0%PRS 77.1%
-
CSI 10.8rCSI 58.0%PRS 82.9%
-
CSI 11.1rCSI 31.1%PRS 82.5%
-
CSI 11.1rCSI 16.3%PRS 68.7%
-
CSI 11.2rCSI 11.1%PRS 67.6%
-
CSI 11.5rCSI 32.9%PRS 82.5%
-
CSI 12.5rCSI 26.6%PRS 81.6%
-
CSI 12.7rCSI 11.3%PRS 71.8%
-
CSI 13.7rCSI 47.9%PRS 83.5%
-
CSI 14.3rCSI 22.0%PRS 65.1%
-
CSI 15.4rCSI 16.0%PRS 78.9%
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Network Configuration
Explore relationships of the current gene. Select an Interaction Source: 'ONTOLOGY' for shared pathways (GO/Reactome) or 'STRING' for protein-protein interactions. Further refine by selecting context genes and comparing Cell Significance Index (CSI) scores between baseline and target cell types and their specific contexts.
Legend:
- Query Gene
-
Node Color (Target Cell CSI, relative to current network):
- Very High
- High
- Medium
- Low
- Very Low
- CSI N/A
- Node Size: Proportional to Target Cell CSI magnitude
- STRING PPI Edge
- Shared Pathway Edge (ONTOLOGY)
Other Information
This section provides additional information about the gene, including a description generated by an AI language model and details about associated proteins.
Genular Protein ID: 1611354401
Symbol: PHLA2_HUMAN
Name: Pleckstrin homology-like domain family A member 2
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 9403053
Title: A 2.5-Mb transcript map of a tumor-suppressing subchromosomal transferable fragment from 11p15.5, and isolation and sequence analysis of three novel genes.
PubMed ID: 9403053
PubMed ID: 9328465
Title: The IPL gene on chromosome 11p15.5 is imprinted in humans and mice and is similar to TDAG51, implicated in Fas expression and apoptosis.
PubMed ID: 9328465
PubMed ID: 9520460
Title: Transcriptional map of 170-kb region at chromosome 11p15.5: identification and mutational analysis of the BWR1A gene reveals the presence of mutations in tumor samples.
PubMed ID: 9520460
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 10594239
Title: A novel pleckstrin homology-related gene family defined by Ipl/Tssc3, TDAG51, and Tih1: tissue-specific expression, chromosomal location, and parental imprinting.
PubMed ID: 10594239
PubMed ID: 10749982
Title: Retention of imprinting of the human apoptosis-related gene TSSC3 in human brain tumors.
PubMed ID: 10749982
DOI: 10.1093/hmg/9.5.757
PubMed ID: 13129680
Title: The product of the imprinted gene IPL marks human villous cytotrophoblast and is lost in complete hydatidiform mole.
PubMed ID: 13129680
PubMed ID: 15457853
Title: Immunohistochemistry for the imprinted gene product IPL/PHLDA2 for facilitating the differential diagnosis of complete hydatidiform mole.
PubMed ID: 15457853
PubMed ID: 15314611
Title: Complete hydatidiform mole retaining a chromosome 11 of maternal origin: molecular genetic analysis of a case.
PubMed ID: 15314611
PubMed ID: 17303335
Title: Upregulation of PHLDA2 in Dicer knockdown HEK293 cells.
PubMed ID: 17303335
PubMed ID: 16584773
Title: Hypoxia regulates the expression of PHLDA2 in primary term human trophoblasts.
PubMed ID: 16584773
PubMed ID: 18691976
Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.
PubMed ID: 18691976
PubMed ID: 18669648
Title: A quantitative atlas of mitotic phosphorylation.
PubMed ID: 18669648
PubMed ID: 19203586
Title: PH domain-only protein PHLDA3 is a p53-regulated repressor of Akt.
PubMed ID: 19203586
PubMed ID: 19369195
Title: Large-scale proteomics analysis of the human kinome.
PubMed ID: 19369195
PubMed ID: 20068231
Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.
PubMed ID: 20068231
PubMed ID: 22814378
Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.
PubMed ID: 22814378
PubMed ID: 23186163
Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.
PubMed ID: 23186163
DOI: 10.1021/pr300630k
Sequence Information:
- Length: 152
- Mass: 17092
- Checksum: 3A1168CBB859FC3B
- Sequence:
MKSPDEVLRE GELEKRSDSL FQLWKKKRGV LTSDRLSLFP ASPRARPKEL RFHSILKVDC VERTGKYVYF TIVTTDHKEI DFRCAGESCW NAAIALALID FQNRRALQDF RSRQERTAPA APAEDAVAAA AAAPSEPSEP SRPSPQPKPR TP