Details for: RRAS

Gene ID: 6237

Symbol: RRAS

Ensembl ID: ENSG00000126458

Description: RAS related

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 133.9160
    Cell Significance Index: -20.8300
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 81.9655
    Cell Significance Index: -20.7900
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 44.2999
    Cell Significance Index: -20.9200
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 42.7562
    Cell Significance Index: -17.3700
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 38.8036
    Cell Significance Index: -19.9600
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 18.5181
    Cell Significance Index: -17.6800
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 16.8781
    Cell Significance Index: -20.8100
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 7.2120
    Cell Significance Index: -19.3200
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 5.3002
    Cell Significance Index: -20.9200
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 4.8348
    Cell Significance Index: -14.8500
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 2.8937
    Cell Significance Index: 150.7300
  • Cell Name: perivascular cell (CL4033054)
    Fold Change: 2.5914
    Cell Significance Index: 11.9700
  • Cell Name: peg cell (CL4033014)
    Fold Change: 2.4542
    Cell Significance Index: 56.7000
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 2.1863
    Cell Significance Index: 416.0700
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 1.9141
    Cell Significance Index: 52.1000
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 1.8423
    Cell Significance Index: 299.6300
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: 1.7110
    Cell Significance Index: 28.2000
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 1.6051
    Cell Significance Index: 96.3600
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 1.3691
    Cell Significance Index: 148.9200
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 1.2199
    Cell Significance Index: 1101.4900
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 1.1029
    Cell Significance Index: 151.4600
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.8875
    Cell Significance Index: 41.7100
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.6587
    Cell Significance Index: 359.7100
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: 0.6132
    Cell Significance Index: 5.0000
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.5950
    Cell Significance Index: 27.7400
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.5835
    Cell Significance Index: 30.3100
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 0.4772
    Cell Significance Index: 13.6800
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.4726
    Cell Significance Index: 58.1100
  • Cell Name: endocardial cell (CL0002350)
    Fold Change: 0.4200
    Cell Significance Index: 2.4800
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.3602
    Cell Significance Index: 64.9400
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.3568
    Cell Significance Index: 157.7600
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.3548
    Cell Significance Index: 35.1000
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.3416
    Cell Significance Index: 7.4000
  • Cell Name: oral mucosa squamous cell (CL1001576)
    Fold Change: 0.3224
    Cell Significance Index: 2.7700
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.1586
    Cell Significance Index: 20.4900
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.1474
    Cell Significance Index: 18.9000
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 0.1381
    Cell Significance Index: 2.4400
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.0884
    Cell Significance Index: 0.9100
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.0662
    Cell Significance Index: 4.9400
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 0.0467
    Cell Significance Index: 0.5300
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.0417
    Cell Significance Index: 2.9500
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: 0.0314
    Cell Significance Index: 0.1900
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0015
    Cell Significance Index: 2.8200
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.0012
    Cell Significance Index: 0.0300
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0032
    Cell Significance Index: -2.4400
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0090
    Cell Significance Index: -16.6000
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0122
    Cell Significance Index: -18.7600
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: -0.0131
    Cell Significance Index: -0.1100
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0140
    Cell Significance Index: -0.7100
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0169
    Cell Significance Index: -12.3900
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0174
    Cell Significance Index: -23.7200
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0180
    Cell Significance Index: -11.4200
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0260
    Cell Significance Index: -11.8100
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0290
    Cell Significance Index: -21.4800
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0304
    Cell Significance Index: -3.1100
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0318
    Cell Significance Index: -6.3200
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.0338
    Cell Significance Index: -1.5300
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0374
    Cell Significance Index: -21.1200
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0431
    Cell Significance Index: -26.9400
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0444
    Cell Significance Index: -15.9200
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0456
    Cell Significance Index: -9.1400
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0568
    Cell Significance Index: -6.6200
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0667
    Cell Significance Index: -19.1900
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0706
    Cell Significance Index: -8.0900
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.0719
    Cell Significance Index: -4.6400
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0788
    Cell Significance Index: -13.4600
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: -0.0885
    Cell Significance Index: -1.3700
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0894
    Cell Significance Index: -3.1400
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.1037
    Cell Significance Index: -15.0800
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1129
    Cell Significance Index: -23.7800
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.1260
    Cell Significance Index: -2.4600
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.1291
    Cell Significance Index: -2.1600
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.1545
    Cell Significance Index: -11.8600
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.1565
    Cell Significance Index: -18.4600
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.1634
    Cell Significance Index: -6.6900
  • Cell Name: glomerular capillary endothelial cell (CL1001005)
    Fold Change: -0.1717
    Cell Significance Index: -0.6400
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.1745
    Cell Significance Index: -4.6600
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1856
    Cell Significance Index: -19.3300
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: -0.2285
    Cell Significance Index: -1.4200
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.2316
    Cell Significance Index: -18.3400
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.2613
    Cell Significance Index: -4.8300
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.2695
    Cell Significance Index: -16.5200
  • Cell Name: kidney interstitial cell (CL1000500)
    Fold Change: -0.2758
    Cell Significance Index: -2.0700
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.2761
    Cell Significance Index: -5.8800
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.2780
    Cell Significance Index: -7.7700
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.2847
    Cell Significance Index: -17.9500
  • Cell Name: luminal hormone-sensing cell of mammary gland (CL4033058)
    Fold Change: -0.2965
    Cell Significance Index: -1.8300
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.3183
    Cell Significance Index: -21.4000
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.3430
    Cell Significance Index: -21.0800
  • Cell Name: keratocyte (CL0002363)
    Fold Change: -0.3492
    Cell Significance Index: -5.5400
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.3607
    Cell Significance Index: -18.9400
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.3906
    Cell Significance Index: -12.5100
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.3960
    Cell Significance Index: -22.2200
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.4104
    Cell Significance Index: -8.5900
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: -0.4510
    Cell Significance Index: -3.7300
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.4648
    Cell Significance Index: -20.5600
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.4688
    Cell Significance Index: -12.5400
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.4789
    Cell Significance Index: -16.6400
  • Cell Name: embryonic fibroblast (CL2000042)
    Fold Change: -0.4808
    Cell Significance Index: -2.3000
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.4883
    Cell Significance Index: -14.3400

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** RRAS is a member of the RAS superfamily, which consists of small GTP-binding proteins that cycle between an inactive GDP-bound state and an active GTP-bound state. The RAS pathway is characterized by the sequential activation of downstream effectors, including RAF, MEK, and ERK, which ultimately regulate gene expression and cellular behavior. RRAS is specifically activated by guanine nucleotide exchange factors (GEFs) and inhibited by GTPase-activating proteins (GAPs). **Pathways and Functions** The RAS pathway, in which RRAS is involved, is a key regulator of various cellular processes, including: 1. **Cell proliferation and differentiation**: RRAS regulates the expression of genes involved in cell growth and differentiation, particularly in the context of vascular development and angiogenesis. 2. **Cell migration and invasion**: RRAS modulates the activity of integrins and other adhesion molecules to regulate cell migration and invasion, which is critical for processes such as wound healing, immune cell migration, and tumor metastasis. 3. **Apoptosis and survival**: The RAS pathway regulates the expression of pro-survival and pro-apoptotic genes, influencing cellular survival and death. 4. **Inflammation and immune response**: RRAS modulates the activity of immune cells, including macrophages and T cells, to regulate inflammation and immune responses. **Clinical Significance** Dysregulation of the RAS pathway, including RRAS, has been implicated in various diseases, including: 1. **Cancer**: Mutations in the RAS gene family, including RRAS, are common in human cancers, such as lung, colon, and pancreatic cancer, and are often associated with poor prognosis. 2. **Cardiovascular disease**: RRAS is involved in the regulation of endothelial cell function and angiogenesis, which is critical for cardiovascular health. Dysregulation of RRAS has been implicated in atherosclerosis and other cardiovascular disorders. 3. **Neurological disorders**: RRAS has been implicated in the regulation of neuronal development and function, and dysregulation of RRAS has been associated with neurological disorders, such as Alzheimer's disease and Parkinson's disease. In conclusion, RRAS is a critical component of the RAS signaling pathway, which plays a key role in regulating various cellular processes, including cell growth, differentiation, migration, and survival. Dysregulation of RRAS has been implicated in various diseases, highlighting the importance of this gene in human health and disease.

Genular Protein ID: 911789952

Symbol: RRAS_HUMAN

Name: Ras-related protein R-Ras

UniProtKB Accession Codes:

P10301 Q6FH12

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChEBI 9 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 9 Ensembl 1 EvolutionaryTrace 1 ExpressionAtlas 1 GO 18 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MalaCards 1 MassIVE 1 MetOSite 1 NCBI Taxonomy 1 NCBIfam 1 OMA 1 OpenTargets 1 Orphanet 2 OrthoDB 1 PANTHER 2 PDB 2 PDBsum 2 PIR 1 PRINTS 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 2 RefSeq 1 Rhea 2 SIGNOR 1 SMART 4 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 3098437

Title: Structure of the human and murine R-ras genes, novel genes closely related to ras proto-oncogenes.

PubMed ID: 3098437

DOI: 10.1016/0092-8674(87)90364-3

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 15242332

Title: Vectorial proteomics reveal targeting, phosphorylation and specific fragmentation of polymerase I and transcript release factor (PTRF) at the surface of caveolae in human adipocytes.

PubMed ID: 15242332

DOI: 10.1042/bj20040647

PubMed ID: 16537651

Title: The small GTPase R-Ras regulates organization of actin and drives membrane protrusions through the activity of PLCepsilon.

PubMed ID: 16537651

DOI: 10.1242/jcs.02835

PubMed ID: 18270267

Title: The R-Ras interaction partner ORP3 regulates cell adhesion.

PubMed ID: 18270267

DOI: 10.1242/jcs.016964

PubMed ID: 20074548

Title: Palmitoylation of R-Ras by human DHHC19, a palmitoyl transferase with a CaaX box.

PubMed ID: 20074548

DOI: 10.1016/j.bbamem.2010.01.002

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 16773572

Title: Germline missense mutations affecting KRAS Isoform B are associated with a severe Noonan syndrome phenotype.

PubMed ID: 16773572

DOI: 10.1086/504394

Sequence Information:

  • Length: 218
  • Mass: 23480
  • Checksum: 437F73170670EB28
  • Sequence:
    • MSSGAASGTG RGRPRGGGPG PGDPPPSETH KLVVVGGGGV GKSALTIQFI QSYFVSDYDP 
TIEDSYTKIC SVDGIPARLD ILDTAGQEEF GAMREQYMRA GHGFLLVFAI NDRQSFNEVG 
KLFTQILRVK DRDDFPVVLV GNKADLESQR QVPRSEASAF GASHHVAYFE ASAKLRLNVD 
EAFEQLVRAV RKYQEQELPP SPPSAPRKKG GGCPCVLL

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.