Details for: SELENOP

Gene ID: 6414

Symbol: SELENOP

Ensembl ID: ENSG00000250722

Description: selenoprotein P

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 192.9978
    Cell Significance Index: -79.5100
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 173.1416
    Cell Significance Index: -70.3400
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 172.9635
    Cell Significance Index: -81.6600
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 73.5800
    Cell Significance Index: -70.2500
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 30.5540
    Cell Significance Index: -81.8500
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 21.3417
    Cell Significance Index: -65.5500
  • Cell Name: theca cell (CL0000503)
    Fold Change: 21.0229
    Cell Significance Index: 123.5100
  • Cell Name: pulmonary interstitial fibroblast (CL0002241)
    Fold Change: 11.7671
    Cell Significance Index: 72.8000
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 8.3079
    Cell Significance Index: 1065.0300
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: 6.9471
    Cell Significance Index: 47.0700
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 5.6982
    Cell Significance Index: 155.1000
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 4.9759
    Cell Significance Index: 63.7300
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: 4.0559
    Cell Significance Index: 79.1600
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 3.9983
    Cell Significance Index: 105.1400
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: 3.8799
    Cell Significance Index: 32.5900
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 3.6699
    Cell Significance Index: 191.1600
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 3.6183
    Cell Significance Index: 496.9000
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 3.3458
    Cell Significance Index: 95.9100
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 2.8816
    Cell Significance Index: 372.2800
  • Cell Name: peg cell (CL4033014)
    Fold Change: 2.7914
    Cell Significance Index: 64.4900
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 2.7375
    Cell Significance Index: 543.2700
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 2.6539
    Cell Significance Index: 197.7900
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 2.1830
    Cell Significance Index: 17.4300
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 1.4239
    Cell Significance Index: 22.0300
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.3789
    Cell Significance Index: 136.4100
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 1.3070
    Cell Significance Index: 577.8600
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 1.2754
    Cell Significance Index: 138.7300
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 1.0680
    Cell Significance Index: 50.2000
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 1.0593
    Cell Significance Index: 18.7200
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 1.0086
    Cell Significance Index: 60.5500
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.7111
    Cell Significance Index: 49.1800
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.6585
    Cell Significance Index: 80.9700
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.6124
    Cell Significance Index: 334.4400
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.5935
    Cell Significance Index: 106.9900
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.4415
    Cell Significance Index: 20.0100
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.3467
    Cell Significance Index: 262.4600
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.3219
    Cell Significance Index: 54.9700
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.3007
    Cell Significance Index: 14.0200
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.2064
    Cell Significance Index: 33.5700
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.1356
    Cell Significance Index: 2.2700
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.1114
    Cell Significance Index: 7.8800
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.1020
    Cell Significance Index: 188.1600
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 0.0941
    Cell Significance Index: 3.2700
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0734
    Cell Significance Index: 2.5800
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.0556
    Cell Significance Index: 10.5900
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.0355
    Cell Significance Index: 26.0300
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.0331
    Cell Significance Index: 3.3800
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0117
    Cell Significance Index: 17.9700
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0097
    Cell Significance Index: -18.2500
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: -0.0172
    Cell Significance Index: -0.1400
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0394
    Cell Significance Index: -25.0500
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0547
    Cell Significance Index: -3.0700
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0628
    Cell Significance Index: -85.3400
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0869
    Cell Significance Index: -2.3200
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.1072
    Cell Significance Index: -79.3900
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.1308
    Cell Significance Index: -59.3600
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.1437
    Cell Significance Index: -81.0200
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.1520
    Cell Significance Index: -43.7400
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.1590
    Cell Significance Index: -99.3100
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1816
    Cell Significance Index: -20.8000
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.1951
    Cell Significance Index: -69.9900
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.3609
    Cell Significance Index: -72.4000
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.4393
    Cell Significance Index: -92.5200
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.4666
    Cell Significance Index: -54.3800
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.4753
    Cell Significance Index: -69.0900
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.5059
    Cell Significance Index: -14.5800
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.5105
    Cell Significance Index: -12.7600
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.6259
    Cell Significance Index: -7.1100
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: -0.6275
    Cell Significance Index: -9.5300
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.6782
    Cell Significance Index: -53.7100
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.6814
    Cell Significance Index: -52.2900
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.6942
    Cell Significance Index: -35.0800
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.7033
    Cell Significance Index: -82.9400
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.7795
    Cell Significance Index: -81.1600
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.7890
    Cell Significance Index: -22.0500
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.8131
    Cell Significance Index: -42.2400
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.8310
    Cell Significance Index: -18.0000
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -1.0196
    Cell Significance Index: -62.6700
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -1.1622
    Cell Significance Index: -78.1500
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -1.2124
    Cell Significance Index: -74.3300
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -1.2744
    Cell Significance Index: -82.2200
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -1.2960
    Cell Significance Index: -81.6800
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -1.3929
    Cell Significance Index: -37.2600
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -1.4036
    Cell Significance Index: -14.5300
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -1.4906
    Cell Significance Index: -78.2600
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -1.5508
    Cell Significance Index: -49.6700
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -1.5786
    Cell Significance Index: -33.6200
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -1.6186
    Cell Significance Index: -66.3200
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -1.6628
    Cell Significance Index: -61.0400
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -1.8395
    Cell Significance Index: -54.1800
  • Cell Name: luminal hormone-sensing cell of mammary gland (CL4033058)
    Fold Change: -1.8695
    Cell Significance Index: -11.5100
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -2.0235
    Cell Significance Index: -30.3200
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -2.0397
    Cell Significance Index: -90.2200
  • Cell Name: melanocyte of skin (CL1000458)
    Fold Change: -2.0983
    Cell Significance Index: -29.4100
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: -2.1080
    Cell Significance Index: -30.6100
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -2.1545
    Cell Significance Index: -55.3800
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -2.1556
    Cell Significance Index: -45.1200
  • Cell Name: myeloid leukocyte (CL0000766)
    Fold Change: -2.2863
    Cell Significance Index: -18.5200
  • Cell Name: Mueller cell (CL0000636)
    Fold Change: -2.2961
    Cell Significance Index: -17.6700
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -2.3072
    Cell Significance Index: -57.6300

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Selenium-binding protein:** SELENOP is a selenium-binding protein that plays a crucial role in the regulation of selenium-dependent enzymes, which are essential for antioxidant defense mechanisms. 2. **Multifunctional protein:** SELENOP has been shown to have multiple functions, including regulation of platelet activation, immune response, and cellular growth. 3. **Extracellular and intracellular localization:** SELENOP is found in both extracellular and intracellular compartments, suggesting its involvement in both local and systemic immune responses. 4. **Cell-type specific expression:** SELENOP is expressed in various cell types, including immune cells, epithelial cells, and fibroblasts, indicating its role in different cellular processes. **Pathways and Functions:** 1. **Immune response:** SELENOP is involved in the regulation of immune responses, including platelet activation and degranulation, which are crucial for the defense against pathogens. 2. **Antioxidant defense:** SELENOP plays a role in regulating antioxidant defense mechanisms, including the activity of selenium-dependent enzymes, which protect cells from oxidative stress. 3. **Cellular growth and development:** SELENOP is involved in the regulation of cellular growth and development, including the regulation of platelet activation and the promotion of spermatogenesis. 4. **Extracellular and endosomal trafficking:** SELENOP is involved in the regulation of extracellular and endosomal trafficking, including the transport of selenium and other molecules. **Clinical Significance:** 1. **Selenium deficiency:** SELENOP is involved in the regulation of selenium-dependent enzymes, which are essential for antioxidant defense mechanisms. Selenium deficiency has been associated with various diseases, including cancer, cardiovascular disease, and neurological disorders. 2. **Immune system disorders:** SELENOP plays a crucial role in regulating immune responses, and dysregulation of SELENOP has been implicated in various immune system disorders, including autoimmune diseases and cancer. 3. **Platelet disorders:** SELENOP is involved in the regulation of platelet activation, and dysregulation of SELENOP has been implicated in various platelet disorders, including thrombocytopenia and thrombosis. 4. **Cancer:** SELENOP has been shown to have anti-tumor properties, and dysregulation of SELENOP has been implicated in various types of cancer, including breast, lung, and colon cancer. In conclusion, SELENOP is a multifunctional gene involved in various cellular processes, including immune response, antioxidant defense, and cellular growth. Dysregulation of SELENOP has been implicated in various diseases, including immune system disorders, platelet disorders, and cancer. Further research is needed to fully understand the role of SELENOP in human health and disease.

Genular Protein ID: 773989020

Symbol: SEPP1_HUMAN

Name: N/A

UniProtKB Accession Codes:

P49908 Q6PD59 Q6PI43 Q6PI87 Q6PJF9

Database IDs:

AGR 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 5 EMBL 8 Ensembl 3 ExpressionAtlas 1 GO 12 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyConnect 1 GlyCosmos 1 GlyGen 1 HGNC 1 HPA 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 1 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 1 RefSeq 3 STRING 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8421687

Title: Conserved nucleotide sequences in the open reading frame and 3' untranslated region of selenoprotein P mRNA.

PubMed ID: 8421687

DOI: 10.1073/pnas.90.2.537

PubMed ID: 15372022

Title: The DNA sequence and comparative analysis of human chromosome 5.

PubMed ID: 15372022

DOI: 10.1038/nature02919

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8142465

Title: Purification of selenoprotein P from human plasma.

PubMed ID: 8142465

DOI: 10.1016/0167-4838(94)90014-0

PubMed ID: 9735174

Title: A novel method for the purification of selenoprotein P from human plasma.

PubMed ID: 9735174

DOI: 10.1006/abbi.1998.0809

PubMed ID: 10775431

Title: Selenoprotein P: properties, functions, and regulation.

PubMed ID: 10775431

DOI: 10.1006/abbi.2000.1735

PubMed ID: 7931697

Title: Selenoprotein P. A selenium-rich extracellular glycoprotein.

PubMed ID: 7931697

DOI: 10.1093/jn/124.10.1891

PubMed ID: 16335952

Title: Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry.

PubMed ID: 16335952

DOI: 10.1021/pr0502065

PubMed ID: 19159218

Title: Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry.

PubMed ID: 19159218

DOI: 10.1021/pr8008012

PubMed ID: 19139490

Title: A strategy for precise and large scale identification of core fucosylated glycoproteins.

PubMed ID: 19139490

DOI: 10.1074/mcp.m800504-mcp200

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 27645994

Title: Selenoprotein gene nomenclature.

PubMed ID: 27645994

DOI: 10.1074/jbc.m116.756155

Sequence Information:

  • Length: 381
  • Mass: 43174
  • Checksum: 00872B8030840B02
  • Sequence:
    • MWRSLGLALA LCLLPSGGTE SQDQSSLCKQ PPAWSIRDQD PMLNSNGSVT VVALLQASUY 
LCILQASKLE DLRVKLKKEG YSNISYIVVN HQGISSRLKY THLKNKVSEH IPVYQQEENQ 
TDVWTLLNGS KDDFLIYDRC GRLVYHLGLP FSFLTFPYVE EAIKIAYCEK KCGNCSLTTL 
KDEDFCKRVS LATVDKTVET PSPHYHHEHH HNHGHQHLGS SELSENQQPG APNAPTHPAP 
PGLHHHHKHK GQHRQGHPEN RDMPASEDLQ DLQKKLCRKR CINQLLCKLP TDSELAPRSU 
CCHCRHLIFE KTGSAITUQC KENLPSLCSU QGLRAEENIT ESCQURLPPA AUQISQQLIP 
TEASASURUK NQAKKUEUPS N

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.