Details for: MXRA7

Gene ID: 439921

Gene Type:  Protein-coding  - A gene that serves as a template for producing a messenger RNA (mRNA) molecule, which is then translated into a functional protein.

Symbol: MXRA7

Ensembl ID: ENSG00000182534

Description: matrix remodeling associated 7

Selected Context(s):  Overall

Cell Significance Landscape

Contexts:

Associated with

Significant Cells

Cell Significance Index (CSI) scores for the chosen context(s)

  • pancreatic D cell CL0000173
    CSI 21.13
    rCSI 20.78%
    PRS 85.54
  • pancreatic A cell CL0000171
    CSI 17.65
    rCSI 18.49%
    PRS 86.32
  • pancreatic ductal cell CL0002079
    CSI 13.34
    rCSI 25.94%
    PRS 86.18
  • stromal cell of ovary CL0002132
    CSI 10.78
    rCSI 29.61%
    PRS 89.02
  • retina horizontal cell CL0000745
    CSI 10.45
    rCSI 15.93%
    PRS 80.12
  • type B pancreatic cell CL0000169
    CSI 9.99
    rCSI 22.12%
    PRS 82.8
  • perivascular cell CL4033054
    CSI 9.5
    rCSI 12.99%
    PRS 87.48
  • pancreatic PP cell CL0002275
    CSI 9.26
    rCSI 36.85%
    PRS 89.11
  • microcirculation associated smooth muscle cell CL0008035
    CSI 9.07
    rCSI 26.25%
    PRS 82.53
  • endothelial cell of placenta CL0009092
    CSI 8.42
    rCSI 41.52%
    PRS 89.68
  • Mueller cell CL0000636
    CSI 8.25
    rCSI 18.84%
    PRS 75.27
  • pancreatic stellate cell CL0002410
    CSI 6.45
    rCSI 37.51%
    PRS 86.37
  • interneuron CL0000099
    CSI 6.01
    rCSI 12.06%
    PRS 74.5
  • myofibroblast cell CL0000186
    CSI 5.54
    rCSI 7.68%
    PRS 80.11
  • skin fibroblast CL0002620
    CSI 5.26
    rCSI 4.54%
    PRS 83.54
  • ionocyte CL0005006
    CSI 5.14
    rCSI 5.51%
    PRS 84.9
  • tracheobronchial smooth muscle cell CL0019019
    CSI 5.1
    rCSI 9%
    PRS 87.73
  • retinal pigment epithelial cell CL0002586
    CSI 4.69
    rCSI 9.31%
    PRS 79.2
  • retinal ganglion cell CL0000740
    CSI 4.46
    rCSI 9.84%
    PRS 69.87
  • OFF-bipolar cell CL0000750
    CSI 4.32
    rCSI 5.91%
    PRS 84.31
  • enteroendocrine cell CL0000164
    CSI 4.31
    rCSI 5.89%
    PRS 82.68
  • retinal cone cell CL0000573
    CSI 4.2
    rCSI 6.76%
    PRS 73.98
  • kidney loop of Henle thin descending limb epithelial cell CL1001111
    CSI 4.11
    rCSI 5.83%
    PRS 80.41
  • adventitial cell CL0002503
    CSI 3.74
    rCSI 8.94%
    PRS 86.62
  • fibroblast of lung CL0002553
    CSI 3.66
    rCSI 3.41%
    PRS 84.12
  • bronchiolar smooth muscle cell CL4033017
    CSI 3.56
    rCSI 53.4%
    PRS 89.99
  • vascular leptomeningeal cell CL4023051
    CSI 3.37
    rCSI 5.91%
    PRS 77.69
  • cardiac endothelial cell CL0010008
    CSI 3.31
    rCSI 13.35%
    PRS 83.42
  • melanocyte CL0000148
    CSI 3.31
    rCSI 2.45%
    PRS 77.46
  • kidney loop of Henle thin ascending limb epithelial cell CL1001107
    CSI 3.29
    rCSI 8.5%
    PRS 79.12
  • neural crest cell CL0011012
    CSI 3.24
    rCSI 2.56%
    PRS 73.23
  • bronchus fibroblast of lung CL2000093
    CSI 3.2
    rCSI 2.6%
    PRS 82.67
  • interstitial cell of Cajal CL0002088
    CSI 3.07
    rCSI 3.91%
    PRS 87.96
  • enteric smooth muscle cell CL0002504
    CSI 3.05
    rCSI 4.36%
    PRS 83.94
  • Bergmann glial cell CL0000644
    CSI 3.05
    rCSI 4.17%
    PRS 74.81
  • cone retinal bipolar cell CL0000752
    CSI 2.91
    rCSI 38.01%
    PRS 82.78
  • blood vessel endothelial cell CL0000071
    CSI 2.9
    rCSI 6.02%
    PRS 80.28
  • choroid plexus epithelial cell CL0000706
    CSI 2.84
    rCSI 4.65%
    PRS 73.54
  • pulmonary capillary endothelial cell CL4028001
    CSI 2.84
    rCSI 5.41%
    PRS 91.46
  • CD4-positive helper T cell CL0000492
    CSI 2.73
    rCSI 2.07%
    PRS 93.5
  • CD8-positive, alpha-beta memory T cell CL0000909
    CSI 2.68
    rCSI 2.8%
    PRS 93.42
  • fallopian tube secretory epithelial cell CL4030006
    CSI 2.65
    rCSI 2.55%
    PRS 82.66
  • hepatic stellate cell CL0000632
    CSI 2.55
    rCSI 9.56%
    PRS 76.34
  • mesenchymal cell CL0008019
    CSI 2.55
    rCSI 6.47%
    PRS 77.12
  • kidney connecting tubule epithelial cell CL1000768
    CSI 2.52
    rCSI 6.4%
    PRS 74.49
  • common dendritic progenitor CL0001029
    CSI 2.42
    rCSI 3.04%
    PRS 90.47
  • epithelial cell of lung CL0000082
    CSI 2.4
    rCSI 1.99%
    PRS 84.39
  • ON-bipolar cell CL0000749
    CSI 2.39
    rCSI 3.55%
    PRS 82.85
  • respiratory suprabasal cell CL4033048
    CSI 2.36
    rCSI 3.02%
    PRS 86.01
  • pulmonary ionocyte CL0017000
    CSI 2.35
    rCSI 2.86%
    PRS 88.86
  • myoepithelial cell CL0000185
    CSI 2.33
    rCSI 5.89%
    PRS 87.44
  • astrocyte of the cerebral cortex CL0002605
    CSI 2.32
    rCSI 5.2%
    PRS 67.24
  • cerebellar granule cell CL0001031
    CSI 2.31
    rCSI 3.39%
    PRS 76.68
  • indirect pathway medium spiny neuron CL4023029
    CSI 2.31
    rCSI 55.63%
    PRS 64.84
  • direct pathway medium spiny neuron CL4023026
    CSI 2.3
    rCSI 55.07%
    PRS 64.28
  • sst GABAergic cortical interneuron CL4023017
    CSI 2.3
    rCSI 2.96%
    PRS 67.49
  • mesodermal cell CL0000222
    CSI 2.29
    rCSI 2.75%
    PRS 81.41
  • peripheral nervous system neuron CL2000032
    CSI 2.29
    rCSI 3.12%
    PRS 75.35
  • pvalb GABAergic cortical interneuron CL4023018
    CSI 2.28
    rCSI 2.84%
    PRS 64.24
  • lung ciliated cell CL1000271
    CSI 2.26
    rCSI 2.61%
    PRS 76.15
  • caudal ganglionic eminence derived cortical interneuron CL4023064
    CSI 2.23
    rCSI 3.95%
    PRS 65.87
  • extravillous trophoblast CL0008036
    CSI 2.23
    rCSI 2.76%
    PRS 81.53
  • smooth muscle cell CL0000192
    CSI 2.2
    rCSI 5.25%
    PRS 78.74
  • differentiation-committed oligodendrocyte precursor CL4023059
    CSI 2.16
    rCSI 3.93%
    PRS 75.16
  • club cell CL0000158
    CSI 2.15
    rCSI 3.15%
    PRS 78.17
  • inhibitory interneuron CL0000498
    CSI 2.14
    rCSI 4.95%
    PRS 71.72
  • basal cell CL0000646
    CSI 2.14
    rCSI 2.86%
    PRS 81.35
  • lung endothelial cell CL1001567
    CSI 2.12
    rCSI 4.95%
    PRS 92.08
  • ciliated epithelial cell CL0000067
    CSI 2.12
    rCSI 1.86%
    PRS 73.13
  • lamp5 GABAergic cortical interneuron CL4023011
    CSI 2.07
    rCSI 3.48%
    PRS 66.31
  • Schwann cell CL0002573
    CSI 2.06
    rCSI 5.85%
    PRS 78.95
  • rod bipolar cell CL0000751
    CSI 2.05
    rCSI 3.69%
    PRS 77.06
  • GABAergic amacrine cell CL4030027
    CSI 2.04
    rCSI 6.97%
    PRS 69.39
  • retinal blood vessel endothelial cell CL0002585
    CSI 2.03
    rCSI 3.24%
    PRS 86.5
  • cerebral cortex neuron CL0010012
    CSI 2.02
    rCSI 8.24%
    PRS 75.17
  • retinal rod cell CL0000604
    CSI 1.96
    rCSI 3.46%
    PRS 78.66
  • alveolar type 1 fibroblast cell CL4028004
    CSI 1.92
    rCSI 2.1%
    PRS 85.07
  • VIP GABAergic cortical interneuron CL4023016
    CSI 1.89
    rCSI 2.26%
    PRS 66.37
  • stromal cell CL0000499
    CSI 1.88
    rCSI 5.28%
    PRS 78.45
  • tendon cell CL0000388
    CSI 1.85
    rCSI 4.81%
    PRS 88.75
  • sncg GABAergic cortical interneuron CL4023015
    CSI 1.84
    rCSI 2.96%
    PRS 67.76
  • keratocyte CL0002363
    CSI 1.83
    rCSI 4.39%
    PRS 85.58
  • alveolar adventitial fibroblast CL4028006
    CSI 1.8
    rCSI 2.85%
    PRS 84.61
  • cerebral cortex endothelial cell CL1001602
    CSI 1.79
    rCSI 3.1%
    PRS 75.52
  • duct epithelial cell CL0000068
    CSI 1.77
    rCSI 2.59%
    PRS 87.7
  • cardiac muscle cell CL0000746
    CSI 1.7
    rCSI 2.43%
    PRS 73.72
  • retinal bipolar neuron CL0000748
    CSI 1.68
    rCSI 3.15%
    PRS 72.36
  • lung pericyte CL0009089
    CSI 1.67
    rCSI 4.4%
    PRS 89
  • pancreatic acinar cell CL0002064
    CSI 1.62
    rCSI 2.15%
    PRS 88.05
  • vascular associated smooth muscle cell CL0000359
    CSI 1.6
    rCSI 5.2%
    PRS 81.38
  • fibroblast of cardiac tissue CL0002548
    CSI 1.6
    rCSI 7.66%
    PRS 83.46
  • pulmonary artery endothelial cell CL1001568
    CSI 1.58
    rCSI 2.14%
    PRS 90.43
  • neuroblast (sensu Vertebrata) CL0000031
    CSI 1.57
    rCSI 2.01%
    PRS 79.58
  • regular atrial cardiac myocyte CL0002129
    CSI 1.53
    rCSI 4.92%
    PRS 80.21
  • stem cell CL0000034
    CSI 1.51
    rCSI 1.46%
    PRS 77.51
  • endothelial cell of pericentral hepatic sinusoid CL0019022
    CSI 1.51
    rCSI 4.65%
    PRS 86.87
  • chondrocyte CL0000138
    CSI 1.5
    rCSI 2.39%
    PRS 76.85
  • mesenchymal stem cell of adipose tissue CL0002570
    CSI 1.5
    rCSI 8.36%
    PRS 85.64
  • OFF midget ganglion cell CL4033047
    CSI 1.44
    rCSI 29.34%
    PRS 74.29
  • amacrine cell CL0000561
    CSI 1.43
    rCSI 4.14%
    PRS 73.19
  • mesenchymal stem cell CL0000134
    CSI 0.2
    rCSI 1.8%
    PRS 87.5%
  • cytotoxic T cell CL0000910
    CSI 0.2
    rCSI 1.3%
    PRS 85.4%
  • central nervous system neuron CL2000029
    CSI 0.3
    rCSI 1.8%
    PRS 71.5%
  • effector memory CD8-positive, alpha-beta T cell, terminally differentiated CL0001062
    CSI 0.3
    rCSI 1.5%
    PRS 93.2%
  • blood vessel smooth muscle cell CL0019018
    CSI 0.3
    rCSI 2.8%
    PRS 78.1%
  • corticothalamic-projecting glutamatergic cortical neuron CL4023013
    CSI 0.5
    rCSI 2.7%
    PRS 66.9%
  • ON parasol ganglion cell CL4033052
    CSI 0.5
    rCSI 7.3%
    PRS 74.6%
  • lung microvascular endothelial cell CL2000016
    CSI 0.8
    rCSI 15.3%
    PRS 89.6%
  • ON midget ganglion cell CL4033046
    CSI 0.8
    rCSI 16.4%
    PRS 73.3%
  • endothelial cell of uterus CL0009095
    CSI 0.9
    rCSI 6.2%
    PRS 89.9%
  • L2/3-6 intratelencephalic projecting glutamatergic neuron CL4023040
    CSI 1.0
    rCSI 2.4%
    PRS 64.2%
  • L5 extratelencephalic projecting glutamatergic cortical neuron CL4023041
    CSI 1.0
    rCSI 3.6%
    PRS 64.2%
  • chandelier pvalb GABAergic cortical interneuron CL4023036
    CSI 1.0
    rCSI 3.2%
    PRS 70.3%
  • vein endothelial cell of respiratory system CL4033008
    CSI 1.1
    rCSI 7.7%
    PRS 88.6%
  • glycinergic amacrine cell CL4030028
    CSI 1.1
    rCSI 2.9%
    PRS 77.5%
  • syncytiotrophoblast cell CL0000525
    CSI 1.1
    rCSI 3.3%
    PRS 87.8%
  • ventricular cardiac muscle cell CL2000046
    CSI 1.2
    rCSI 4.1%
    PRS 89.8%
  • regular ventricular cardiac myocyte CL0002131
    CSI 1.3
    rCSI 8.1%
    PRS 75.7%
  • uterine smooth muscle cell CL0002601
    CSI 1.3
    rCSI 8.7%
    PRS 88.3%
  • respiratory basal cell CL0002633
    CSI 1.3
    rCSI 1.4%
    PRS 86.6%
  • renal interstitial pericyte CL1001318
    CSI 1.4
    rCSI 3.8%
    PRS 78.8%
  • glial cell CL0000125
    CSI 1.4
    rCSI 5.2%
    PRS 74.8%
  • amacrine cell CL0000561
    CSI 1.4
    rCSI 4.1%
    PRS 73.2%
  • OFF midget ganglion cell CL4033047
    CSI 1.4
    rCSI 29.3%
    PRS 74.3%
  • mesenchymal stem cell of adipose tissue CL0002570
    CSI 1.5
    rCSI 8.4%
    PRS 85.6%
  • chondrocyte CL0000138
    CSI 1.5
    rCSI 2.4%
    PRS 76.9%
  • endothelial cell of pericentral hepatic sinusoid CL0019022
    CSI 1.5
    rCSI 4.7%
    PRS 86.9%
  • stem cell CL0000034
    CSI 1.5
    rCSI 1.5%
    PRS 77.5%
  • regular atrial cardiac myocyte CL0002129
    CSI 1.5
    rCSI 4.9%
    PRS 80.2%
  • neuroblast (sensu Vertebrata) CL0000031
    CSI 1.6
    rCSI 2.0%
    PRS 79.6%
  • pulmonary artery endothelial cell CL1001568
    CSI 1.6
    rCSI 2.1%
    PRS 90.4%
  • fibroblast of cardiac tissue CL0002548
    CSI 1.6
    rCSI 7.7%
    PRS 83.5%
  • vascular associated smooth muscle cell CL0000359
    CSI 1.6
    rCSI 5.2%
    PRS 81.4%
  • pancreatic acinar cell CL0002064
    CSI 1.6
    rCSI 2.2%
    PRS 88.1%
  • lung pericyte CL0009089
    CSI 1.7
    rCSI 4.4%
    PRS 89.0%
  • retinal bipolar neuron CL0000748
    CSI 1.7
    rCSI 3.2%
    PRS 72.4%
  • cardiac muscle cell CL0000746
    CSI 1.7
    rCSI 2.4%
    PRS 73.7%
  • duct epithelial cell CL0000068
    CSI 1.8
    rCSI 2.6%
    PRS 87.7%
  • cerebral cortex endothelial cell CL1001602
    CSI 1.8
    rCSI 3.1%
    PRS 75.5%
  • alveolar adventitial fibroblast CL4028006
    CSI 1.8
    rCSI 2.9%
    PRS 84.6%
  • keratocyte CL0002363
    CSI 1.8
    rCSI 4.4%
    PRS 85.6%
  • sncg GABAergic cortical interneuron CL4023015
    CSI 1.8
    rCSI 3.0%
    PRS 67.8%
  • tendon cell CL0000388
    CSI 1.9
    rCSI 4.8%
    PRS 88.8%
  • stromal cell CL0000499
    CSI 1.9
    rCSI 5.3%
    PRS 78.5%
  • VIP GABAergic cortical interneuron CL4023016
    CSI 1.9
    rCSI 2.3%
    PRS 66.4%
  • alveolar type 1 fibroblast cell CL4028004
    CSI 1.9
    rCSI 2.1%
    PRS 85.1%
  • retinal rod cell CL0000604
    CSI 2.0
    rCSI 3.5%
    PRS 78.7%
  • cerebral cortex neuron CL0010012
    CSI 2.0
    rCSI 8.2%
    PRS 75.2%
  • retinal blood vessel endothelial cell CL0002585
    CSI 2.0
    rCSI 3.2%
    PRS 86.5%
  • GABAergic amacrine cell CL4030027
    CSI 2.0
    rCSI 7.0%
    PRS 69.4%
  • rod bipolar cell CL0000751
    CSI 2.1
    rCSI 3.7%
    PRS 77.1%
  • Schwann cell CL0002573
    CSI 2.1
    rCSI 5.9%
    PRS 79.0%
  • lamp5 GABAergic cortical interneuron CL4023011
    CSI 2.1
    rCSI 3.5%
    PRS 66.3%
  • ciliated epithelial cell CL0000067
    CSI 2.1
    rCSI 1.9%
    PRS 73.1%
  • lung endothelial cell CL1001567
    CSI 2.1
    rCSI 5.0%
    PRS 92.1%
  • basal cell CL0000646
    CSI 2.1
    rCSI 2.9%
    PRS 81.4%
  • inhibitory interneuron CL0000498
    CSI 2.1
    rCSI 5.0%
    PRS 71.7%
  • club cell CL0000158
    CSI 2.2
    rCSI 3.2%
    PRS 78.2%
  • differentiation-committed oligodendrocyte precursor CL4023059
    CSI 2.2
    rCSI 3.9%
    PRS 75.2%
  • smooth muscle cell CL0000192
    CSI 2.2
    rCSI 5.3%
    PRS 78.7%
  • extravillous trophoblast CL0008036
    CSI 2.2
    rCSI 2.8%
    PRS 81.5%
  • caudal ganglionic eminence derived cortical interneuron CL4023064
    CSI 2.2
    rCSI 4.0%
    PRS 65.9%
  • lung ciliated cell CL1000271
    CSI 2.3
    rCSI 2.6%
    PRS 76.2%
  • pvalb GABAergic cortical interneuron CL4023018
    CSI 2.3
    rCSI 2.8%
    PRS 64.2%
  • peripheral nervous system neuron CL2000032
    CSI 2.3
    rCSI 3.1%
    PRS 75.4%
  • mesodermal cell CL0000222
    CSI 2.3
    rCSI 2.8%
    PRS 81.4%
  • sst GABAergic cortical interneuron CL4023017
    CSI 2.3
    rCSI 3.0%
    PRS 67.5%
  • direct pathway medium spiny neuron CL4023026
    CSI 2.3
    rCSI 55.1%
    PRS 64.3%
  • indirect pathway medium spiny neuron CL4023029
    CSI 2.3
    rCSI 55.6%
    PRS 64.8%
  • cerebellar granule cell CL0001031
    CSI 2.3
    rCSI 3.4%
    PRS 76.7%
  • astrocyte of the cerebral cortex CL0002605
    CSI 2.3
    rCSI 5.2%
    PRS 67.2%
  • myoepithelial cell CL0000185
    CSI 2.3
    rCSI 5.9%
    PRS 87.4%
  • pulmonary ionocyte CL0017000
    CSI 2.4
    rCSI 2.9%
    PRS 88.9%
  • respiratory suprabasal cell CL4033048
    CSI 2.4
    rCSI 3.0%
    PRS 86.0%
  • ON-bipolar cell CL0000749
    CSI 2.4
    rCSI 3.6%
    PRS 82.9%
  • epithelial cell of lung CL0000082
    CSI 2.4
    rCSI 2.0%
    PRS 84.4%
  • common dendritic progenitor CL0001029
    CSI 2.4
    rCSI 3.0%
    PRS 90.5%
  • kidney connecting tubule epithelial cell CL1000768
    CSI 2.5
    rCSI 6.4%
    PRS 74.5%
  • mesenchymal cell CL0008019
    CSI 2.6
    rCSI 6.5%
    PRS 77.1%
  • hepatic stellate cell CL0000632
    CSI 2.6
    rCSI 9.6%
    PRS 76.3%
  • fallopian tube secretory epithelial cell CL4030006
    CSI 2.7
    rCSI 2.6%
    PRS 82.7%
  • CD8-positive, alpha-beta memory T cell CL0000909
    CSI 2.7
    rCSI 2.8%
    PRS 93.4%
  • CD4-positive helper T cell CL0000492
    CSI 2.7
    rCSI 2.1%
    PRS 93.5%
  • pulmonary capillary endothelial cell CL4028001
    CSI 2.8
    rCSI 5.4%
    PRS 91.5%
  • choroid plexus epithelial cell CL0000706
    CSI 2.8
    rCSI 4.7%
    PRS 73.5%
  • blood vessel endothelial cell CL0000071
    CSI 2.9
    rCSI 6.0%
    PRS 80.3%
  • cone retinal bipolar cell CL0000752
    CSI 2.9
    rCSI 38.0%
    PRS 82.8%
  • Bergmann glial cell CL0000644
    CSI 3.1
    rCSI 4.2%
    PRS 74.8%
  • enteric smooth muscle cell CL0002504
    CSI 3.1
    rCSI 4.4%
    PRS 83.9%
  • interstitial cell of Cajal CL0002088
    CSI 3.1
    rCSI 3.9%
    PRS 88.0%
  • bronchus fibroblast of lung CL2000093
    CSI 3.2
    rCSI 2.6%
    PRS 82.7%
  • neural crest cell CL0011012
    CSI 3.2
    rCSI 2.6%
    PRS 73.2%
  • kidney loop of Henle thin ascending limb epithelial cell CL1001107
    CSI 3.3
    rCSI 8.5%
    PRS 79.1%
  • melanocyte CL0000148
    CSI 3.3
    rCSI 2.5%
    PRS 77.5%
  • cardiac endothelial cell CL0010008
    CSI 3.3
    rCSI 13.4%
    PRS 83.4%
  • vascular leptomeningeal cell CL4023051
    CSI 3.4
    rCSI 5.9%
    PRS 77.7%
  • bronchiolar smooth muscle cell CL4033017
    CSI 3.6
    rCSI 53.4%
    PRS 90.0%
  • fibroblast of lung CL0002553
    CSI 3.7
    rCSI 3.4%
    PRS 84.1%
  • adventitial cell CL0002503
    CSI 3.7
    rCSI 8.9%
    PRS 86.6%
  • kidney loop of Henle thin descending limb epithelial cell CL1001111
    CSI 4.1
    rCSI 5.8%
    PRS 80.4%

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Network Configuration

Explore relationships of the current gene. Select an Interaction Source: 'ONTOLOGY' for shared pathways (GO/Reactome) or 'STRING' for protein-protein interactions. Further refine by selecting context genes and comparing Cell Significance Index (CSI) scores between baseline and target cell types and their specific contexts.

Comma-separated if multiple.
Comma-separated if multiple.

Legend:
  • Query Gene
  • Node Color (Target Cell CSI, relative to current network):
    • Very High
    • High
    • Medium
    • Low
    • Very Low
    • CSI N/A
  • Node Size: Proportional to Target Cell CSI magnitude
  • STRING PPI Edge
  • Shared Pathway Edge (ONTOLOGY)

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Other Information

This section provides additional information about the gene, including a description generated by an AI language model and details about associated proteins.

## Summary [MXRA7](/details-gene/439921) (Matrix Remodeling Associated 7) is a protein-coding gene located on chromosome 17q25.1. Functional annotations suggest the encoded protein is associated with the [collagen-containing extracellular matrix](/details-go/GO:0062023), the [endoplasmic reticulum](/details-go/GO:0005783), and the [membrane](/details-go/GO:0016020). Its expression profile indicates a significant role within the pancreas, where it shows high specificity for endocrine cells such as [pancreatic D cell](/details-cell/CL0000173) and [pancreatic A cell](/details-cell/CL0000171), as well as in [pancreatic ductal cell](/details-cell/CL0002079). This pattern, combined with its name, suggests a potential function in maintaining the structural architecture and cellular environment of pancreatic islets and other specialized tissues. ## Cellular Roles and Expression Landscape The expression landscape of [MXRA7](/details-gene/439921) highlights its prominent role in specialized glandular, stromal, and neural-support tissues. **Overall**, the gene exhibits its highest significance in the pancreas, marking key endocrine populations including [pancreatic D cell](/details-cell/CL0000173), [pancreatic A cell](/details-cell/CL0000171), [type B pancreatic cell](/details-cell/CL0000169), and [pancreatic PP cell](/details-cell/CL0002275). Its high expression in [pancreatic ductal cell](/details-cell/CL0002079) and [pancreatic stellate cell](/details-cell/CL0002410) further implicates it in the structural and exocrine components of this organ. Beyond the pancreas, [MXRA7](/details-gene/439921) is a significant marker in other diverse cell types that contribute to tissue structure and microenvironments. These include [stromal cell of ovary](/details-cell/CL0002132), specialized retinal cells like [retina horizontal cell](/details-cell/CL0000745) and [Mueller cell](/details-cell/CL0000636), and cells associated with the vasculature such as [perivascular cell](/details-cell/CL4033054) and [endothelial cell of placenta](/details-cell/CL0009092). Its consistent expression in mesenchymal-derived cells, including [myofibroblast cell](/details-cell/CL0000186) and [skin fibroblast](/details-cell/CL0002620), suggests a widespread, albeit specific, role in matrix biology and tissue maintenance across different organ systems. ## Pathways and Molecular Function The functional annotations for [MXRA7](/details-gene/439921) are consistent with its observed expression pattern in matrix-secreting and stromal cells. Its association with the [collagen-containing extracellular matrix](/details-go/GO:0062023) directly aligns with its "Matrix Remodeling Associated" name and its high expression in fibroblasts, stellate cells, and stromal cells, which are primary regulators of the extracellular environment. The localization to the [membrane](/details-go/GO:0016020) and the [endoplasmic reticulum](/details-go/GO:0005783) suggests that the [MXRA7](/details-gene/439921) protein is likely a transmembrane or secreted protein that is processed through the canonical secretory pathway before being trafficked to the cell surface or extracellular space. This function would enable it to directly participate in cell-matrix adhesion, signal transduction from the extracellular environment, or the enzymatic modification of matrix components. Its characterization has been supported by several large-scale human genome and proteome-sequencing projects ([Link](https://doi.org/10.1038/nature04689), [Link](https://doi.org/10.1038/nature03001), [Link](https://doi.org/10.1186/1752-0509-5-17)). ## Research Directions The specific role of [MXRA7](/details-gene/439921) in tissue biology remains poorly defined, but its distinct expression pattern provides a foundation for targeted investigation. The gene's high significance in multiple pancreatic cell types, including both endocrine and structural cells, makes it a compelling candidate for studies on pancreatic homeostasis and disease. **Proposed Hypotheses:** 1. Given its name and high expression in pancreatic endocrine and ductal cells, [MXRA7](/details-gene/439921) may be essential for maintaining the structural integrity of pancreatic islets. It could function as a linker protein that anchors islet cells to the surrounding extracellular matrix, thereby influencing cell survival, organization, and hormone secretion. 2. In cells known to drive fibrosis, such as [pancreatic stellate cell](/details-cell/CL0002410) and [myofibroblast cell](/details-cell/CL0000186), [MXRA7](/details-gene/439921) expression might be upregulated during tissue injury, contributing to pathological matrix deposition in diseases like pancreatitis or pancreatic cancer. **Experimental Approach:** To test the hypothesis that [MXRA7](/details-gene/439921) is critical for pancreatic islet architecture, a cell-type-specific knockout mouse model could be developed. Using a Cre-Lox system with a *Pdx1-Cre* driver would enable the deletion of [MXRA7](/details-gene/439921) specifically in pancreatic progenitor cells. The resulting adult mice could be analyzed for defects in islet morphology, cellular composition, and basement membrane integrity using immunofluorescence and electron microscopy. Functional consequences could be assessed via glucose and insulin tolerance tests to determine if the structural deficits translate to impaired endocrine function. **Therapeutic Potential:** As a putative membrane-bound or secreted protein, [MXRA7](/details-gene/439921) is a potentially druggable target. If its role in pathological matrix remodeling and fibrosis is confirmed, it could be a target for inhibition in diseases characterized by excessive scarring, such as idiopathic pulmonary fibrosis or pancreatic fibrosis. A therapeutic strategy involving a monoclonal antibody or small molecule inhibitor targeting the extracellular domain of [MXRA7](/details-gene/439921) could potentially disrupt its function in matrix deposition or cell adhesion, thereby ameliorating the fibrotic process. Its specific expression pattern suggests that such a therapy might have a favorable safety profile with limited off-target effects.

Genular Protein ID: 3431253988

Symbol: MXRA7_HUMAN

Name: Matrix-remodeling-associated protein 7

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 16625196

Title: DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage.

PubMed ID: 16625196

DOI: 10.1038/nature04689

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

Sequence Information:

  • Length: 204
  • Mass: 21466
  • Checksum: 3298195FCAC7AECF
  • Sequence:
  • MEAPAELLAA LPALATALAL LLAWLLVRRG AAASPEPARA PPEPAPPAEA TGAPAPSRPC 
    APEPAASPAG PEEPGEPAGL GELGEPAGPG EPEGPGDPAA APAEAEEQAV EARQEEEQDL 
    DGEKGPSSEG PEEEDGEGFS FKYSPGKLRG NQYKKMMTKE ELEEEQRVQK EQLAAIFKLM 
    KDNKETFGEM SDGDVQEQLR LYDM

Genular Protein ID: 1916117085

Symbol: Q6ZR64_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

PubMed ID: 16625196

Title: DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage.

PubMed ID: 16625196

DOI: 10.1038/nature04689

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

Sequence Information:

  • Length: 213
  • Mass: 23412
  • Checksum: F4DC433E47378382
  • Sequence:
  • MDTERVGDGK QHRRKQSQRL RWPCCLALVP DRHPSQLSSC TLCLLAAASQ WESWAHFSKW 
    HTEASTGTHL GKAKAEGLGC TVKNTPQLSI CEPSHFGPSF VHSPHLLVDH DHRAGAATGR 
    GQAGPSRASS VSPTFCPPTT SHHPVCAKGT DPVLVLQEEE QDLDGEKGPS SEGPEEEDGE 
    GFSFKYSPGK LRGNQYKKMM TKEELEEEQR TEE