Details for: IGFBP2

Gene ID: 3485

Symbol: IGFBP2

Ensembl ID: ENSG00000115457

Description: insulin like growth factor binding protein 2

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: double-positive, alpha-beta thymocyte (CL0000809)
    Fold Change: 5.57
    Marker Score: 10916
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: 3.96
    Marker Score: 5460
  • Cell Name: basal cell of epithelium of trachea (CL1000348)
    Fold Change: 3.44
    Marker Score: 25585
  • Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
    Fold Change: 3.35
    Marker Score: 29115
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 3.17
    Marker Score: 109682.5
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 3.08
    Marker Score: 34739
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 3
    Marker Score: 19520
  • Cell Name: fibroblast of connective tissue of glandular part of prostate (CL1000305)
    Fold Change: 2.9
    Marker Score: 1209
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 2.74
    Marker Score: 11837
  • Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
    Fold Change: 2.63
    Marker Score: 1653
  • Cell Name: fibroblast of connective tissue of nonglandular part of prostate (CL1000304)
    Fold Change: 2.61
    Marker Score: 2227
  • Cell Name: peptic cell (CL0000155)
    Fold Change: 2.61
    Marker Score: 1093
  • Cell Name: mucous neck cell (CL0000651)
    Fold Change: 2.55
    Marker Score: 5781
  • Cell Name: type EC enteroendocrine cell (CL0000577)
    Fold Change: 2.51
    Marker Score: 2362
  • Cell Name: Leydig cell (CL0000178)
    Fold Change: 2.48
    Marker Score: 2670
  • Cell Name: mesothelial cell of epicardium (CL0011019)
    Fold Change: 2.4
    Marker Score: 769
  • Cell Name: fibroblast of connective tissue of prostate (CL1000299)
    Fold Change: 2.39
    Marker Score: 596
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: 2.39
    Marker Score: 8862
  • Cell Name: prostate stromal cell (CL0002622)
    Fold Change: 2.37
    Marker Score: 596
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 2.37
    Marker Score: 3485
  • Cell Name: uterine smooth muscle cell (CL0002601)
    Fold Change: 2.33
    Marker Score: 3038
  • Cell Name: P/D1 enteroendocrine cell (CL0002268)
    Fold Change: 2.33
    Marker Score: 868
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 2.32
    Marker Score: 23361
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 2.3
    Marker Score: 5626
  • Cell Name: migratory enteric neural crest cell (CL0002607)
    Fold Change: 2.28
    Marker Score: 2144
  • Cell Name: multi-ciliated epithelial cell (CL0005012)
    Fold Change: 2.27
    Marker Score: 4322
  • Cell Name: kidney collecting duct principal cell (CL1001431)
    Fold Change: 2.26
    Marker Score: 5692
  • Cell Name: myoepithelial cell of mammary gland (CL0002324)
    Fold Change: 2.25
    Marker Score: 11057
  • Cell Name: peripheral nervous system neuron (CL2000032)
    Fold Change: 2.24
    Marker Score: 2520
  • Cell Name: respiratory epithelial cell (CL0002368)
    Fold Change: 2.23
    Marker Score: 1227.5
  • Cell Name: endothelial cell of uterus (CL0009095)
    Fold Change: 2.2
    Marker Score: 4403
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 2.18
    Marker Score: 4601
  • Cell Name: myeloid lineage restricted progenitor cell (CL0000839)
    Fold Change: 2.17
    Marker Score: 746
  • Cell Name: epithelial cell of urethra (CL1000296)
    Fold Change: 2.14
    Marker Score: 1690
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: 2.09
    Marker Score: 18028
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 2.07
    Marker Score: 2180
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: 2.06
    Marker Score: 1718
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: 2.05
    Marker Score: 1057
  • Cell Name: neural crest cell (CL0011012)
    Fold Change: 2.03
    Marker Score: 2174
  • Cell Name: decidual natural killer cell, human (CL0002343)
    Fold Change: 2.03
    Marker Score: 5616
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: 1.98
    Marker Score: 12632
  • Cell Name: corneal endothelial cell (CL0000132)
    Fold Change: 1.94
    Marker Score: 1131
  • Cell Name: malignant cell (CL0001064)
    Fold Change: 1.88
    Marker Score: 25231
  • Cell Name: basal cell (CL0000646)
    Fold Change: 1.88
    Marker Score: 2422
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: 1.85
    Marker Score: 4962
  • Cell Name: Unknown (CL0002371)
    Fold Change: 1.8
    Marker Score: 1911
  • Cell Name: lung microvascular endothelial cell (CL2000016)
    Fold Change: 1.79
    Marker Score: 380
  • Cell Name: male germ cell (CL0000015)
    Fold Change: 1.74
    Marker Score: 502
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: 1.73
    Marker Score: 5943
  • Cell Name: inhibitory motor neuron (CL0008015)
    Fold Change: 1.72
    Marker Score: 814
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: 1.66
    Marker Score: 12986.5
  • Cell Name: interstitial cell of Cajal (CL0002088)
    Fold Change: 1.66
    Marker Score: 574
  • Cell Name: supporting cell (CL0000630)
    Fold Change: 1.63
    Marker Score: 3062
  • Cell Name: renal interstitial pericyte (CL1001318)
    Fold Change: 1.59
    Marker Score: 1520
  • Cell Name: vein endothelial cell (CL0002543)
    Fold Change: 1.59
    Marker Score: 1438
  • Cell Name: paneth cell (CL0000510)
    Fold Change: 1.55
    Marker Score: 1080
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 1.54
    Marker Score: 2613.5
  • Cell Name: type G enteroendocrine cell (CL0000508)
    Fold Change: 1.53
    Marker Score: 527
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: 1.51
    Marker Score: 8103
  • Cell Name: stem cell (CL0000034)
    Fold Change: 1.5
    Marker Score: 3562
  • Cell Name: motor neuron (CL0000100)
    Fold Change: 1.49
    Marker Score: 887
  • Cell Name: midzonal region hepatocyte (CL0019028)
    Fold Change: 1.49
    Marker Score: 6443
  • Cell Name: skin fibroblast (CL0002620)
    Fold Change: 1.49
    Marker Score: 386
  • Cell Name: ovarian surface epithelial cell (CL2000064)
    Fold Change: 1.49
    Marker Score: 4042
  • Cell Name: primordial germ cell (CL0000670)
    Fold Change: 1.47
    Marker Score: 1842
  • Cell Name: mural cell (CL0008034)
    Fold Change: 1.46
    Marker Score: 167579
  • Cell Name: mammary gland epithelial cell (CL0002327)
    Fold Change: 1.43
    Marker Score: 509
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 1.43
    Marker Score: 5495
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 1.4
    Marker Score: 692
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 1.38
    Marker Score: 1399
  • Cell Name: lung ciliated cell (CL1000271)
    Fold Change: 1.37
    Marker Score: 648
  • Cell Name: colon epithelial cell (CL0011108)
    Fold Change: 1.36
    Marker Score: 4283
  • Cell Name: kidney interstitial cell (CL1000500)
    Fold Change: 1.34
    Marker Score: 951
  • Cell Name: prostate gland microvascular endothelial cell (CL2000059)
    Fold Change: 1.32
    Marker Score: 514
  • Cell Name: retinal blood vessel endothelial cell (CL0002585)
    Fold Change: 1.31
    Marker Score: 315
  • Cell Name: endothelial cell of sinusoid (CL0002262)
    Fold Change: 1.29
    Marker Score: 314
  • Cell Name: enteroendocrine cell (CL0000164)
    Fold Change: 1.26
    Marker Score: 655
  • Cell Name: smooth muscle cell of prostate (CL1000487)
    Fold Change: 1.25
    Marker Score: 319
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: 1.25
    Marker Score: 1434
  • Cell Name: intestine goblet cell (CL0019031)
    Fold Change: 1.23
    Marker Score: 1183
  • Cell Name: podocyte (CL0000653)
    Fold Change: 1.23
    Marker Score: 453
  • Cell Name: respiratory goblet cell (CL0002370)
    Fold Change: 1.22
    Marker Score: 353
  • Cell Name: acinar cell (CL0000622)
    Fold Change: 1.22
    Marker Score: 859.5
  • Cell Name: pericyte (CL0000669)
    Fold Change: 1.21
    Marker Score: 706
  • Cell Name: cardiac mesenchymal cell (CL0000569)
    Fold Change: 1.21
    Marker Score: 297
  • Cell Name: mesodermal cell (CL0000222)
    Fold Change: 1.21
    Marker Score: 15910
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 1.2
    Marker Score: 7706
  • Cell Name: fetal cardiomyocyte (CL0002495)
    Fold Change: 1.19
    Marker Score: 393
  • Cell Name: precursor cell (CL0011115)
    Fold Change: 1.18
    Marker Score: 287
  • Cell Name: parietal epithelial cell (CL1000452)
    Fold Change: 1.18
    Marker Score: 428
  • Cell Name: alternatively activated macrophage (CL0000890)
    Fold Change: 1.17
    Marker Score: 489
  • Cell Name: oogonial cell (CL0000024)
    Fold Change: 1.16
    Marker Score: 1673
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 1.14
    Marker Score: 760
  • Cell Name: intestinal crypt stem cell (CL0002250)
    Fold Change: 1.13
    Marker Score: 425
  • Cell Name: skeletal muscle satellite cell (CL0000594)
    Fold Change: 1.13
    Marker Score: 754
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: 1.11
    Marker Score: 1759
  • Cell Name: bronchus fibroblast of lung (CL2000093)
    Fold Change: 1.09
    Marker Score: 1496
  • Cell Name: endothelial tip cell (CL0000704)
    Fold Change: 1.08
    Marker Score: 251
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: 1.06
    Marker Score: 698
  • Cell Name: kidney interstitial fibroblast (CL1000692)
    Fold Change: 1.06
    Marker Score: 2038.5

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Other Information

**Key characteristics:** * IGFBP2 is a transmembrane protein with a molecular weight of approximately 120 kDa. * It is expressed in a variety of cell types, including epithelial cells, stromal cells, and immune cells. * It is a key regulator of the IGF signaling pathway, which is responsible for the development and maintenance of tissues such as the skin, bones, and muscles. * It is also involved in the regulation of cell growth and differentiation. **Pathways and functions:** * IGFBP2 binds to IGFs, which are proteins that are secreted by cells to regulate their growth and development. * When IGFBP2 binds to an IGF, it translocates to the cell surface and recruits IGFs into the cell. * This allows the IGFs to exert their effects on the target cells. * The IGF/IGFBP2 axis is involved in a variety of cellular processes, including cell growth, differentiation, proliferation, and apoptosis. **Clinical significance:** * Mutations in the IGFBP2 gene have been linked to a number of human diseases, including diabetes, cancer, and cardiovascular disease. * IGFBP2 is a promising target for the treatment of these diseases. * Small molecule inhibitors of IGFBP2 have been shown to be effective in treating cancer and other diseases that are caused by IGF-dependent cells. **Additional notes:** * IGFBP2 is a highly conserved protein, with similar proteins found in other mammals. * It is a key regulator of the growth and development of the human body. * It is a promising target for the treatment of a variety of human diseases.

Genular Protein ID: 4155540003

Symbol: IBP2_HUMAN

Name: Insulin-like growth factor-binding protein 2

UniProtKB Accession Codes:

P18065 Q14619 Q9UCL3

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BMRB 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CORUM 1 CTD 1 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 1 EMBL 18 EPD 1 Ensembl 1 EvolutionaryTrace 1 ExpressionAtlas 1 GO 19 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 7 KEGG 1 MANE-Select 1 MEROPS 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 2 PDBsum 1 PIR 1 PRINTS 2 PRO 1 PROSITE 4 PROSITE-ProRule 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 1 RefSeq 4 SAM 1 SIGNOR 1 SMART 2 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 2479552

Title: Cloning, sequence analysis and expression of a cDNA encoding a novel insulin-like growth factor binding protein (IGFBP-2).

PubMed ID: 2479552

DOI: 10.1002/j.1460-2075.1989.tb08386.x

PubMed ID: 1697583

Title: Isolation from adult human serum of four insulin-like growth factor (IGF) binding proteins and molecular cloning of one of them that is increased by IGF I administration and in extrapancreatic tumor hypoglycemia.

PubMed ID: 1697583

DOI: 10.1016/s0021-9258(18)77200-1

PubMed ID: 1710112

Title: Structure and localization of the human insulin-like growth factor-binding protein 2 gene.

PubMed ID: 1710112

DOI: 10.1016/0006-291x(91)90420-c

PubMed ID: 1712312

Title: Sequence analysis, expression and chromosomal localization of a gene, isolated from a subtracted human retina cDNA library, that encodes an insulin-like growth factor binding protein (IGFBP2).

PubMed ID: 1712312

DOI: 10.1016/0014-4835(91)90056-k

PubMed ID: 1376411

Title: Structure of the human insulin-like growth factor binding protein-2 gene.

PubMed ID: 1376411

DOI: 10.1210/mend.6.5.1376411

PubMed ID: 15815621

Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.

PubMed ID: 15815621

DOI: 10.1038/nature03466

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 1726837

Title: Purification from human cerebrospinal fluid of insulin-like growth factor binding proteins (IGFBPs). Isolation of IGFBP-2, an altered form of IGFBP-3 and a new IGFBP species.

PubMed ID: 1726837

PubMed ID: 19081843

Title: Duplication of the IGFBP-2 gene in teleost fish: protein structure and functionality conservation and gene expression divergence.

PubMed ID: 19081843

DOI: 10.1371/journal.pone.0003926

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 17020769

Title: Structure, dynamics and heparin binding of the C-terminal domain of insulin-like growth factor-binding protein-2 (IGFBP-2).

PubMed ID: 17020769

DOI: 10.1016/j.jmb.2006.09.006

Sequence Information:

  • Length: 325
  • Mass: 34814
  • Checksum: 9E1436DBCCC6EA2A
  • Sequence:
    • MLPRVGCPAL PLPPPPLLPL LLLLLGASGG GGGARAEVLF RCPPCTPERL AACGPPPVAP 
PAAVAAVAGG ARMPCAELVR EPGCGCCSVC ARLEGEACGV YTPRCGQGLR CYPHPGSELP 
LQALVMGEGT CEKRRDAEYG ASPEQVADNG DDHSEGGLVE NHVDSTMNML GGGGSAGRKP 
LKSGMKELAV FREKVTEQHR QMGKGGKHHL GLEEPKKLRP PPARTPCQQE LDQVLERIST 
MRLPDERGPL EHLYSLHIPN CDKHGLYNLK QCKMSLNGQR GECWCVNPNT GKLIQGAPTI 
RGDPECHLFY NEQQEARGVH TQRMQ

Genular Protein ID: 3348336959

Symbol: C9JMY1_HUMAN

Name: N/A

UniProtKB Accession Codes:

C9JMY1

Database IDs:

ARBA 2 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CDD 1 CTD 1 ChiTaRS 1 DNASU 1 EMBL 2 EPD 1 Ensembl 2 ExpressionAtlas 1 GO 3 Gene3D 1 GeneTree 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 InterPro 4 MassIVE 1 MaxQB 2 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PRINTS 2 PROSITE 3 PROSITE-ProRule 1 PeptideAtlas 1 Pfam 1 Proteomes 2 ProteomicsDB 1 RefSeq 1 SAM 1 SMART 1 SMR 1 SUPFAM 1 UCSC 1 VEuPathDB 1

Citations:

PubMed ID: 15815621

Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.

PubMed ID: 15815621

DOI: 10.1038/nature03466

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

Sequence Information:

  • Length: 181
  • Mass: 20281
  • Checksum: 7978686EE4472E92
  • Sequence:
    • MPCNNGDDHS EGGLVENHVD STMNMLGGGG SAGRKPLKSG MKELAVFREK VTEQHRQMGK 
GGKHHLGLEE PKKLRPPPAR TPCQQELDQV LERISTMRLP DERGPLEHLY SLHIPNCDKH 
GLYNLKQCKM SLNGQRGECW CVNPNTGKLI QGAPTIRGDP ECHLFYNEQQ EARGVHTQRM 
Q

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.