Gene LUM - ENSG00000139329 | NCBI Gene ID: 4060

Details for: LUM

Gene ID: 4060

Symbol: LUM

Ensembl ID: ENSG00000139329

Description: lumican

Associated with

Defective b4galt1 causes b4galt1-cdg (cdg-2d)
(R-HSA-3656244)
Defective chst6 causes mcdc1
(R-HSA-3656225)
Defective st3gal3 causes mct12 and eiee15
(R-HSA-3656243)
Disease
(R-HSA-1643685)
Diseases associated with glycosaminoglycan metabolism
(R-HSA-3560782)
Diseases of glycosylation
(R-HSA-3781865)
Diseases of metabolism
(R-HSA-5668914)
Ecm proteoglycans
(R-HSA-3000178)
Extracellular matrix organization
(R-HSA-1474244)
Glycosaminoglycan metabolism
(R-HSA-1630316)
Integrin cell surface interactions
(R-HSA-216083)
Keratan sulfate/keratin metabolism
(R-HSA-1638074)
Keratan sulfate biosynthesis
(R-HSA-2022854)
Keratan sulfate degradation
(R-HSA-2022857)
Metabolism
(R-HSA-1430728)
Metabolism of carbohydrates
(R-HSA-71387)
Collagen-containing extracellular matrix
(GO:0062023)
Collagen binding
(GO:0005518)
Collagen fibril organization
(GO:0030199)
Extracellular exosome
(GO:0070062)
Extracellular matrix
(GO:0031012)
Extracellular matrix structural constituent
(GO:0005201)
Extracellular matrix structural constituent conferring compression resistance
(GO:0030021)
Extracellular region
(GO:0005576)
Extracellular space
(GO:0005615)
Fibrillar collagen trimer
(GO:0005583)
Golgi lumen
(GO:0005796)
Lysosomal lumen
(GO:0043202)
Positive regulation of transcription by rna polymerase ii
(GO:0045944)
Positive regulation of transforming growth factor beta1 production
(GO:0032914)
Protein binding
(GO:0005515)
Visual perception
(GO:0007601)

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: fibroblast of connective tissue of nonglandular part of prostate (CL1000304)
Fold Change: 4
Marker Score: 3408
Cell Name: bronchus fibroblast of lung (CL2000093)
Fold Change: 3.99
Marker Score: 5486
Cell Name: fibroblast of mammary gland (CL0002555)
Fold Change: 3.88
Marker Score: 131901
Cell Name: mesenchymal stem cell (CL0000134)
Fold Change: 3.77
Marker Score: 5808
Cell Name: fibroblast of lung (CL0002553)
Fold Change: 3.75
Marker Score: 9806
Cell Name: theca cell (CL0000503)
Fold Change: 3.67
Marker Score: 2632
Cell Name: inflammatory cell (CL0009002)
Fold Change: 3.32
Marker Score: 1428
Cell Name: fibroblast of connective tissue of glandular part of prostate (CL1000305)
Fold Change: 3.3
Marker Score: 1376
Cell Name: stromal cell of ovary (CL0002132)
Fold Change: 3.01
Marker Score: 33896
Cell Name: decidual cell (CL2000002)
Fold Change: 2.98
Marker Score: 12840
Cell Name: stromal cell of lamina propria of small intestine (CL0009022)
Fold Change: 2.62
Marker Score: 589
Cell Name: mesodermal cell (CL0000222)
Fold Change: 2.36
Marker Score: 31121
Cell Name: fibroblast of connective tissue of prostate (CL1000299)
Fold Change: 2.33
Marker Score: 579
Cell Name: prostate stromal cell (CL0002622)
Fold Change: 2.31
Marker Score: 579
Cell Name: preosteoblast (CL0007010)
Fold Change: 2.28
Marker Score: 645
Cell Name: myofibroblast cell (CL0000186)
Fold Change: 2.03
Marker Score: 2501.5
Cell Name: pancreatic stellate cell (CL0002410)
Fold Change: 1.98
Marker Score: 1249
Cell Name: fibroblast (CL0000057)
Fold Change: 1.92
Marker Score: 1850
Cell Name: skin fibroblast (CL0002620)
Fold Change: 1.76
Marker Score: 456
Cell Name: alveolar type 2 fibroblast cell (CL4028006)
Fold Change: 1.75
Marker Score: 976
Cell Name: colon goblet cell (CL0009039)
Fold Change: 1.59
Marker Score: 1153
Cell Name: supporting cell (CL0000630)
Fold Change: 1.48
Marker Score: 2780
Cell Name: mural cell (CL0008034)
Fold Change: 1.47
Marker Score: 168960
Cell Name: mesenchymal lymphangioblast (CL0005021)
Fold Change: 1.42
Marker Score: 318
Cell Name: eukaryotic cell (CL0000255)
Fold Change: 1.42
Marker Score: 732
Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: 1.4
Marker Score: 1394
Cell Name: fibroblast of breast (CL4006000)
Fold Change: 1.39
Marker Score: 793
Cell Name: kidney interstitial fibroblast (CL1000692)
Fold Change: 1.29
Marker Score: 2489
Cell Name: adipose microvascular endothelial cell (CL2000072)
Fold Change: 1.27
Marker Score: 379
Cell Name: myeloid leukocyte (CL0000766)
Fold Change: 1.26
Marker Score: 1521.5
Cell Name: adventitial cell (CL0002503)
Fold Change: 1.24
Marker Score: 305
Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 1.14
Marker Score: 4786
Cell Name: interstitial cell of Cajal (CL0002088)
Fold Change: 1.12
Marker Score: 387
Cell Name: keratocyte (CL0002363)
Fold Change: 1.08
Marker Score: 248
Cell Name: stem cell of epidermis (CL1000428)
Fold Change: 1.06
Marker Score: 358
Cell Name: uterine smooth muscle cell (CL0002601)
Fold Change: 1.04
Marker Score: 1349
Cell Name: skeletal muscle fibroblast (CL0011027)
Fold Change: 1.03
Marker Score: 678
Cell Name: glandular epithelial cell (CL0000150)
Fold Change: 1.02
Marker Score: 2497
Cell Name: reticular cell (CL0000432)
Fold Change: 1
Marker Score: 365
Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
Fold Change: 1
Marker Score: 71790
Cell Name: forebrain radial glial cell (CL0013000)
Fold Change: 1
Marker Score: 48015
Cell Name: absorptive cell (CL0000212)
Fold Change: 0.98
Marker Score: 30405
Cell Name: tuft cell of colon (CL0009041)
Fold Change: 0.97
Marker Score: 498.5
Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
Fold Change: 0.96
Marker Score: 452
Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 0.95
Marker Score: 2410
Cell Name: interstitial cell of ovary (CL0002094)
Fold Change: 0.94
Marker Score: 6093
Cell Name: transit amplifying cell (CL0009010)
Fold Change: 0.92
Marker Score: 5250
Cell Name: abnormal cell (CL0001061)
Fold Change: 0.91
Marker Score: 2731
Cell Name: small intestine goblet cell (CL1000495)
Fold Change: 0.91
Marker Score: 364
Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 0.88
Marker Score: 317
Cell Name: neoplastic cell (CL0001063)
Fold Change: 0.87
Marker Score: 5275
Cell Name: decidual natural killer cell, human (CL0002343)
Fold Change: 0.86
Marker Score: 2383
Cell Name: placental villous trophoblast (CL2000060)
Fold Change: 0.85
Marker Score: 3348
Cell Name: double negative thymocyte (CL0002489)
Fold Change: 0.81
Marker Score: 1119
Cell Name: intestinal epithelial cell (CL0002563)
Fold Change: 0.78
Marker Score: 1262
Cell Name: early T lineage precursor (CL0002425)
Fold Change: 0.76
Marker Score: 578
Cell Name: tendon cell (CL0000388)
Fold Change: 0.76
Marker Score: 186
Cell Name: muscle cell (CL0000187)
Fold Change: 0.75
Marker Score: 212
Cell Name: Cajal-Retzius cell (CL0000695)
Fold Change: 0.75
Marker Score: 386.5
Cell Name: brush cell (CL0002204)
Fold Change: 0.73
Marker Score: 666
Cell Name: hematopoietic stem cell (CL0000037)
Fold Change: 0.72
Marker Score: 380
Cell Name: Mueller cell (CL0000636)
Fold Change: 0.71
Marker Score: 985
Cell Name: chondrocyte (CL0000138)
Fold Change: 0.7
Marker Score: 316.5
Cell Name: Hofbauer cell (CL3000001)
Fold Change: 0.69
Marker Score: 382
Cell Name: ventricular cardiac muscle cell (CL2000046)
Fold Change: 0.69
Marker Score: 287
Cell Name: Leydig cell (CL0000178)
Fold Change: 0.69
Marker Score: 744
Cell Name: fibroblast of cardiac tissue (CL0002548)
Fold Change: 0.69
Marker Score: 4135
Cell Name: neutrophil progenitor cell (CL0000834)
Fold Change: 0.68
Marker Score: 175
Cell Name: pericyte (CL0000669)
Fold Change: 0.67
Marker Score: 390
Cell Name: lactocyte (CL0002325)
Fold Change: 0.67
Marker Score: 10708.5
Cell Name: stromal cell (CL0000499)
Fold Change: 0.66
Marker Score: 768
Cell Name: connective tissue cell (CL0002320)
Fold Change: 0.63
Marker Score: 163
Cell Name: osteoblast (CL0000062)
Fold Change: 0.62
Marker Score: 334
Cell Name: enterocyte of colon (CL1000347)
Fold Change: 0.6
Marker Score: 924
Cell Name: blood vessel smooth muscle cell (CL0019018)
Fold Change: 0.57
Marker Score: 151
Cell Name: endothelial cell of uterus (CL0009095)
Fold Change: 0.56
Marker Score: 1121
Cell Name: transit amplifying cell of small intestine (CL0009012)
Fold Change: 0.56
Marker Score: 230.5
Cell Name: intestinal enteroendocrine cell (CL1001516)
Fold Change: 0.55
Marker Score: 442
Cell Name: precursor cell (CL0011115)
Fold Change: 0.55
Marker Score: 134
Cell Name: cardiac neuron (CL0010022)
Fold Change: 0.53
Marker Score: 662
Cell Name: lymphocyte (CL0000542)
Fold Change: 0.51
Marker Score: 260
Cell Name: mammary gland epithelial cell (CL0002327)
Fold Change: 0.51
Marker Score: 182
Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: 0.5
Marker Score: 231
Cell Name: smooth muscle cell of prostate (CL1000487)
Fold Change: 0.5
Marker Score: 127
Cell Name: granulocyte monocyte progenitor cell (CL0000557)
Fold Change: 0.49
Marker Score: 309
Cell Name: cell of skeletal muscle (CL0000188)
Fold Change: 0.48
Marker Score: 364
Cell Name: common myeloid progenitor (CL0000049)
Fold Change: 0.47
Marker Score: 125
Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
Fold Change: 0.47
Marker Score: 196
Cell Name: cerebral cortex endothelial cell (CL1001602)
Fold Change: 0.45
Marker Score: 270
Cell Name: intestinal tuft cell (CL0019032)
Fold Change: 0.45
Marker Score: 141
Cell Name: immature innate lymphoid cell (CL0001082)
Fold Change: 0.44
Marker Score: 897
Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
Fold Change: 0.44
Marker Score: 265
Cell Name: type B pancreatic cell (CL0000169)
Fold Change: 0.44
Marker Score: 436
Cell Name: fat cell (CL0000136)
Fold Change: 0.44
Marker Score: 244
Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
Fold Change: 0.43
Marker Score: 293
Cell Name: alternatively activated macrophage (CL0000890)
Fold Change: 0.43
Marker Score: 178
Cell Name: cardiac endothelial cell (CL0010008)
Fold Change: 0.42
Marker Score: 799
Cell Name: endothelial cell (CL0000115)
Fold Change: 0.42
Marker Score: 372
Cell Name: leptomeningeal cell (CL0000708)
Fold Change: 0.41
Marker Score: 205
Cell Name: smooth muscle cell (CL0000192)
Fold Change: 0.41
Marker Score: 267

Hover over a box to see details here...

**Key characteristics:** * Gene name: LUM * Ensembl ID: ENSG00000139329 * Protein: LUM_HUMAN * Protein length: 1,510 amino acids * Exons: 13 * Introns: 11 **Pathways and functions:** * The LUM protein is a key component of the ECM of connective tissues. * It is involved in the organization of collagen fibers, which are a major component of the ECM. * LUM also interacts with other ECM proteins, such as proteoglycans and glycoproteins, to form a stable and functional ECM. * The protein is also involved in the regulation of cell migration and adhesion. **Clinical significance:** * Mutations in the LUM gene have been linked to several diseases, including prostate cancer, lung cancer, and breast cancer. * These mutations can lead to changes in the structure and function of the ECM, which can result in the development of cancer. * Understanding the role of LUM in the ECM and cancer development is important for the development of new diagnostic and therapeutic strategies. **Additional notes:** * The LUM gene is also expressed in other tissues, such as the skin, cartilage, and bone. * The protein is also involved in wound healing and tissue repair. * Mutations in the LUM gene have been linked to a number of inflammatory diseases, such as rheumatoid arthritis and osteoarthritis.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

Lumican

Genular Protein ID: 3348890190

Symbol: LUM_HUMAN

Name: Lumican

UniProtKB Accession Codes:

P51884 B2R6R5 Q96QM7

Database IDs:

Citations:

PubMed ID: 7665616

Title: The human lumican gene. Organization, chromosomal location, and expression in articular cartilage.

PubMed ID: 7665616

DOI: 10.1074/jbc.270.37.21942

PubMed ID: 7558030

Title: Primary structure of human lumican (keratan sulfate proteoglycan) and localization of the gene (LUM) to chromosome 12q21.3-q22.

PubMed ID: 7558030

DOI: 10.1006/geno.1995.1080

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 14551184

Title: Identification of tyrosine sulfation in extracellular leucine-rich repeat proteins using mass spectrometry.

PubMed ID: 14551184

DOI: 10.1074/jbc.m308689200

PubMed ID: 14760718

Title: Screening for N-glycosylated proteins by liquid chromatography mass spectrometry.

PubMed ID: 14760718

DOI: 10.1002/pmic.200300556

PubMed ID: 16335952

Title: Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry.

PubMed ID: 16335952

DOI: 10.1021/pr0502065

PubMed ID: 19159218

Title: Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry.

PubMed ID: 19159218

DOI: 10.1021/pr8008012

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 21220648

Title: Resequencing of 29 candidate genes in patients with familial and sporadic amyotrophic lateral sclerosis.

PubMed ID: 21220648

DOI: 10.1001/archneurol.2010.351

Sequence Information:

Length: 338
Mass: 38429
Checksum: 905D2EBD370CC59D
Sequence:

MSLSAFTLFL ALIGGTSGQY YDYDFPLSIY GQSSPNCAPE CNCPESYPSA MYCDELKLKS 
VPMVPPGIKY LYLRNNQIDH IDEKAFENVT DLQWLILDHN LLENSKIKGR VFSKLKQLKK 
LHINHNNLTE SVGPLPKSLE DLQLTHNKIT KLGSFEGLVN LTFIHLQHNR LKEDAVSAAF 
KGLKSLEYLD LSFNQIARLP SGLPVSLLTL YLDNNKISNI PDEYFKRFNA LQYLRLSHNE 
LADSGIPGNS FNVSSLVELD LSYNKLKNIP TVNENLENYY LEVNQLEKFD IKSFCKILGP 
LSYSKIKHLR LDGNRISETS LPPDMYECLR VANEVTLN

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.

Details for: LUM

Associated with

Cells (max top 100)

Other Information

The human lumican gene. Organization, chromosomal location, and expression in articular cartilage. PubMed ID: 7665616

Primary structure of human lumican (keratan sulfate proteoglycan) and localization of the gene (LUM) to chromosome 12q21.3-q22. PubMed ID: 7558030

Complete sequencing and characterization of 21,243 full-length human cDNAs. PubMed ID: 14702039

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Identification of tyrosine sulfation in extracellular leucine-rich repeat proteins using mass spectrometry. PubMed ID: 14551184

Screening for N-glycosylated proteins by liquid chromatography mass spectrometry. PubMed ID: 14760718

Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry. PubMed ID: 16335952

Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry. PubMed ID: 19159218

An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. PubMed ID: 24275569

Resequencing of 29 candidate genes in patients with familial and sporadic amyotrophic lateral sclerosis. PubMed ID: 21220648