Details for: LUM

Gene ID: 4060

Symbol: LUM

Ensembl ID: ENSG00000139329

Description: lumican

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 169.6613
    Cell Significance Index: -26.3900
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 59.8377
    Cell Significance Index: -24.6500
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 46.6510
    Cell Significance Index: -22.0300
  • Cell Name: theca cell (CL0000503)
    Fold Change: 34.0322
    Cell Significance Index: 199.9400
  • Cell Name: pulmonary interstitial fibroblast (CL0002241)
    Fold Change: 21.5671
    Cell Significance Index: 133.4300
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 21.4038
    Cell Significance Index: -26.3900
  • Cell Name: inflammatory cell (CL0009002)
    Fold Change: 18.6099
    Cell Significance Index: 106.7100
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 15.3285
    Cell Significance Index: 320.8500
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 11.8215
    Cell Significance Index: 338.8700
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 8.9520
    Cell Significance Index: 1147.6000
  • Cell Name: prostate stromal cell (CL0002622)
    Fold Change: 7.3830
    Cell Significance Index: 35.1600
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 6.5052
    Cell Significance Index: -25.6700
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: 5.3420
    Cell Significance Index: 104.2600
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: 3.0300
    Cell Significance Index: 32.9400
  • Cell Name: chondroblast (CL0000058)
    Fold Change: 1.9727
    Cell Significance Index: 11.5800
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 1.9595
    Cell Significance Index: 269.1000
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 1.7961
    Cell Significance Index: 51.7500
  • Cell Name: embryonic fibroblast (CL2000042)
    Fold Change: 1.4717
    Cell Significance Index: 7.0400
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 1.3766
    Cell Significance Index: 17.6300
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: 1.3209
    Cell Significance Index: 8.9500
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 1.3023
    Cell Significance Index: 5.4200
  • Cell Name: preosteoblast (CL0007010)
    Fold Change: 1.2209
    Cell Significance Index: 11.0800
  • Cell Name: fibroblast of connective tissue of glandular part of prostate (CL1000305)
    Fold Change: 1.1941
    Cell Significance Index: 13.1900
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.9937
    Cell Significance Index: 14.2700
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 0.9514
    Cell Significance Index: 14.7200
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.5579
    Cell Significance Index: 25.2900
  • Cell Name: muscle fibroblast (CL1001609)
    Fold Change: 0.5567
    Cell Significance Index: 3.4100
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: 0.5145
    Cell Significance Index: 26.0000
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.4543
    Cell Significance Index: 86.4600
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.2692
    Cell Significance Index: 243.1100
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.2329
    Cell Significance Index: 5.0500
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.2207
    Cell Significance Index: 21.8400
  • Cell Name: fibroblast of connective tissue of nonglandular part of prostate (CL1000304)
    Fold Change: 0.2016
    Cell Significance Index: 2.2000
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.1796
    Cell Significance Index: 3.0100
  • Cell Name: skin fibroblast (CL0002620)
    Fold Change: 0.1039
    Cell Significance Index: 0.2400
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.0848
    Cell Significance Index: 13.8000
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0127
    Cell Significance Index: -9.4000
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0134
    Cell Significance Index: -25.1600
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0139
    Cell Significance Index: -0.4900
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0156
    Cell Significance Index: -9.7600
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0201
    Cell Significance Index: -15.1900
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0205
    Cell Significance Index: -37.7600
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0244
    Cell Significance Index: -37.6100
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0275
    Cell Significance Index: -37.4000
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0329
    Cell Significance Index: -18.5500
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0360
    Cell Significance Index: -22.8700
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: -0.0485
    Cell Significance Index: -21.4600
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0528
    Cell Significance Index: -28.8600
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: -0.0588
    Cell Significance Index: -6.4000
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.0600
    Cell Significance Index: -1.5000
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0609
    Cell Significance Index: -27.6500
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0654
    Cell Significance Index: -11.8000
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0678
    Cell Significance Index: -24.3300
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0699
    Cell Significance Index: -11.9300
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0782
    Cell Significance Index: -10.1000
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0873
    Cell Significance Index: -18.3900
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0925
    Cell Significance Index: -26.6300
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0933
    Cell Significance Index: -6.9500
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.1013
    Cell Significance Index: -20.1000
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: -0.1079
    Cell Significance Index: -1.0400
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.1145
    Cell Significance Index: -8.7900
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.1329
    Cell Significance Index: -8.1500
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.1330
    Cell Significance Index: -3.5500
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.1390
    Cell Significance Index: -27.8800
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.1400
    Cell Significance Index: -15.9800
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.1456
    Cell Significance Index: -16.9700
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: -0.1570
    Cell Significance Index: -1.2800
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: -0.1610
    Cell Significance Index: -11.1400
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.1634
    Cell Significance Index: -20.0900
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1750
    Cell Significance Index: -20.0500
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.1831
    Cell Significance Index: -26.6100
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.1889
    Cell Significance Index: -8.8800
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.2394
    Cell Significance Index: -2.7200
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.2418
    Cell Significance Index: -24.7000
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.2572
    Cell Significance Index: -26.7800
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: -0.3094
    Cell Significance Index: -18.5800
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.3102
    Cell Significance Index: -9.9400
  • Cell Name: perivascular cell (CL4033054)
    Fold Change: -0.3400
    Cell Significance Index: -1.5700
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.3507
    Cell Significance Index: -5.2900
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.3738
    Cell Significance Index: -19.4700
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.3838
    Cell Significance Index: -25.8100
  • Cell Name: fibroblast of lung (CL0002553)
    Fold Change: -0.3916
    Cell Significance Index: -4.6600
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.3978
    Cell Significance Index: -22.3200
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.4320
    Cell Significance Index: -27.2300
  • Cell Name: fibroblast of breast (CL4006000)
    Fold Change: -0.4659
    Cell Significance Index: -2.9300
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.4723
    Cell Significance Index: -29.0300
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.4784
    Cell Significance Index: -14.0900
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.5024
    Cell Significance Index: -14.0400
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.5255
    Cell Significance Index: -21.5300
  • Cell Name: fibroblast of the aortic adventitia (CL0002547)
    Fold Change: -0.5876
    Cell Significance Index: -5.9300
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.5930
    Cell Significance Index: -27.6500
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.5971
    Cell Significance Index: -31.3500
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.6023
    Cell Significance Index: -22.1100
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.6353
    Cell Significance Index: -16.3300
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.6597
    Cell Significance Index: -28.6900
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.6798
    Cell Significance Index: -18.2200
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.6853
    Cell Significance Index: -35.6000
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.6884
    Cell Significance Index: -23.9200
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: -0.7876
    Cell Significance Index: -24.9100
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.7888
    Cell Significance Index: -34.8900

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** Lumican is a small, secreted proteoglycan composed of a core protein domain and one or two glycosaminoglycan (GAG) chains. Its structure allows it to interact with collagen fibrils, modulating their organization and stability. Lumican is expressed in a variety of tissues, including fibroblasts, mesenchymal stem cells, and decidual cells, and its expression is regulated by various signaling pathways, including those involving transforming growth factor-beta (TGF-β) and insulin-like growth factor-1 (IGF-1). **Pathways and Functions:** Lumican's interactions with collagen fibrils are mediated by its leucine-rich repeats, which bind to collagen type I and type III. This binding regulates the organization of collagen fibrils, influencing the mechanical properties of the ECM. Lumican also regulates the activity of various enzymes involved in ECM remodeling, including matrix metalloproteinases (MMPs) and tissue inhibitors of metalloproteinases (TIMPs). Additionally, lumican interacts with integrins, which are essential for cell adhesion and migration, and modulates the activity of growth factors, such as TGF-β and IGF-1. **Clinical Significance:** Dysregulation of lumican has been implicated in various diseases, including: 1. **Atherosclerosis:** Lumican's ability to regulate collagen fibril organization and confer compression resistance to the ECM is critical in maintaining vascular integrity. Mutations in the LUM gene have been associated with an increased risk of atherosclerosis. 2. **Osteoarthritis:** Lumican's interaction with collagen fibrils and regulation of ECM remodeling are essential for maintaining cartilage integrity. Mutations in the LUM gene have been associated with osteoarthritis. 3. **Visual Impairment:** Lumican's interaction with collagen fibrils and regulation of ECM organization are critical for maintaining retinal integrity. Mutations in the LUM gene have been associated with visual impairment and retinal degeneration. 4. **Cancer:** Lumican's interaction with collagen fibrils and regulation of ECM remodeling are essential for maintaining tumor microenvironment. Dysregulation of lumican has been implicated in various types of cancer, including breast, lung, and prostate cancer. In conclusion, the lumican gene plays a critical role in the organization and function of the extracellular matrix. Its dysregulation has been implicated in various diseases, including those affecting the cardiovascular, musculoskeletal, and visual systems. Further research is needed to fully elucidate the mechanisms by which lumican regulates ECM organization and function, and to explore the therapeutic potential of targeting lumican in the treatment of these diseases.

Genular Protein ID: 3348890190

Symbol: LUM_HUMAN

Name: Lumican

UniProtKB Accession Codes:

P51884 B2R6R5 Q96QM7

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 1 EMBL 7 Ensembl 1 ExpressionAtlas 1 GO 15 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyConnect 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRINTS 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 3 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 7 RefSeq 1 SMART 4 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TopDownProteomics 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 7665616

Title: The human lumican gene. Organization, chromosomal location, and expression in articular cartilage.

PubMed ID: 7665616

DOI: 10.1074/jbc.270.37.21942

PubMed ID: 7558030

Title: Primary structure of human lumican (keratan sulfate proteoglycan) and localization of the gene (LUM) to chromosome 12q21.3-q22.

PubMed ID: 7558030

DOI: 10.1006/geno.1995.1080

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 14551184

Title: Identification of tyrosine sulfation in extracellular leucine-rich repeat proteins using mass spectrometry.

PubMed ID: 14551184

DOI: 10.1074/jbc.m308689200

PubMed ID: 14760718

Title: Screening for N-glycosylated proteins by liquid chromatography mass spectrometry.

PubMed ID: 14760718

DOI: 10.1002/pmic.200300556

PubMed ID: 16335952

Title: Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry.

PubMed ID: 16335952

DOI: 10.1021/pr0502065

PubMed ID: 19159218

Title: Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry.

PubMed ID: 19159218

DOI: 10.1021/pr8008012

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 21220648

Title: Resequencing of 29 candidate genes in patients with familial and sporadic amyotrophic lateral sclerosis.

PubMed ID: 21220648

DOI: 10.1001/archneurol.2010.351

Sequence Information:

  • Length: 338
  • Mass: 38429
  • Checksum: 905D2EBD370CC59D
  • Sequence:
    • MSLSAFTLFL ALIGGTSGQY YDYDFPLSIY GQSSPNCAPE CNCPESYPSA MYCDELKLKS 
VPMVPPGIKY LYLRNNQIDH IDEKAFENVT DLQWLILDHN LLENSKIKGR VFSKLKQLKK 
LHINHNNLTE SVGPLPKSLE DLQLTHNKIT KLGSFEGLVN LTFIHLQHNR LKEDAVSAAF 
KGLKSLEYLD LSFNQIARLP SGLPVSLLTL YLDNNKISNI PDEYFKRFNA LQYLRLSHNE 
LADSGIPGNS FNVSSLVELD LSYNKLKNIP TVNENLENYY LEVNQLEKFD IKSFCKILGP 
LSYSKIKHLR LDGNRISETS LPPDMYECLR VANEVTLN

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.