Details for: MYLK

Gene ID: 4638

Symbol: MYLK

Ensembl ID: ENSG00000065534

Description: myosin light chain kinase

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 211.1283
    Cell Significance Index: -32.8400
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 126.5162
    Cell Significance Index: -32.0900
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 72.2941
    Cell Significance Index: -29.3700
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 65.2161
    Cell Significance Index: -30.7900
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 64.6208
    Cell Significance Index: -33.2400
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 30.8879
    Cell Significance Index: -29.4900
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 26.6433
    Cell Significance Index: -32.8500
  • Cell Name: enteric smooth muscle cell (CL0002504)
    Fold Change: 23.1232
    Cell Significance Index: 121.6800
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 12.6677
    Cell Significance Index: -33.9400
  • Cell Name: pulmonary interstitial fibroblast (CL0002241)
    Fold Change: 8.5902
    Cell Significance Index: 53.1500
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 8.3476
    Cell Significance Index: -32.9400
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 3.1006
    Cell Significance Index: 52.2300
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 2.4385
    Cell Significance Index: 127.0200
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: 2.4328
    Cell Significance Index: 253.3100
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 1.9218
    Cell Significance Index: 3618.4600
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 1.6033
    Cell Significance Index: 727.6700
  • Cell Name: theca cell (CL0000503)
    Fold Change: 1.4953
    Cell Significance Index: 8.7900
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 1.2000
    Cell Significance Index: 21.2100
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 1.0559
    Cell Significance Index: 145.0100
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.6723
    Cell Significance Index: 86.1900
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.6664
    Cell Significance Index: 132.2600
  • Cell Name: peg cell (CL4033014)
    Fold Change: 0.6428
    Cell Significance Index: 14.8500
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.6238
    Cell Significance Index: 563.2400
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.6209
    Cell Significance Index: 222.6900
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.5820
    Cell Significance Index: 116.7500
  • Cell Name: perivascular cell (CL4033054)
    Fold Change: 0.5295
    Cell Significance Index: 2.4500
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 0.4489
    Cell Significance Index: 5.1000
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.2969
    Cell Significance Index: 48.3000
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.2744
    Cell Significance Index: 7.4700
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.2590
    Cell Significance Index: 179.1000
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.2097
    Cell Significance Index: 9.5100
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.1921
    Cell Significance Index: 20.9000
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: 0.1679
    Cell Significance Index: 1.4100
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.1649
    Cell Significance Index: 16.3100
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.1570
    Cell Significance Index: 85.7600
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.1133
    Cell Significance Index: 50.1000
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0996
    Cell Significance Index: 153.4000
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.0943
    Cell Significance Index: 17.9400
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0795
    Cell Significance Index: 146.6200
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: 0.0732
    Cell Significance Index: 1.0800
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.0632
    Cell Significance Index: 1.5800
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.0569
    Cell Significance Index: 3.9400
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.0415
    Cell Significance Index: 0.7000
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0392
    Cell Significance Index: 24.8900
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 0.0388
    Cell Significance Index: 0.6000
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.0315
    Cell Significance Index: 23.1000
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: 0.0157
    Cell Significance Index: 9.8300
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0112
    Cell Significance Index: 15.2400
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.0098
    Cell Significance Index: 0.5500
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.0042
    Cell Significance Index: -0.1200
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0054
    Cell Significance Index: -0.1900
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0169
    Cell Significance Index: -1.0400
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0237
    Cell Significance Index: -17.5600
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0341
    Cell Significance Index: -19.2500
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0402
    Cell Significance Index: -30.4300
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0666
    Cell Significance Index: -9.6800
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.0674
    Cell Significance Index: -1.4600
  • Cell Name: smooth muscle cell of prostate (CL1000487)
    Fold Change: -0.0734
    Cell Significance Index: -0.8500
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0783
    Cell Significance Index: -14.1200
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1028
    Cell Significance Index: -21.6600
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.1036
    Cell Significance Index: -29.8100
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.1109
    Cell Significance Index: -18.9300
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.1147
    Cell Significance Index: -11.7200
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.1497
    Cell Significance Index: -10.5900
  • Cell Name: basal-myoepithelial cell of mammary gland (CL0002324)
    Fold Change: -0.1567
    Cell Significance Index: -1.1600
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.1879
    Cell Significance Index: -23.1100
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.2034
    Cell Significance Index: -12.8200
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.2058
    Cell Significance Index: -26.5900
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.2477
    Cell Significance Index: -28.8700
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.2509
    Cell Significance Index: -28.7500
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.2768
    Cell Significance Index: -16.9700
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.2861
    Cell Significance Index: -33.7400
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.2872
    Cell Significance Index: -32.7900
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.3120
    Cell Significance Index: -24.7100
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -0.3285
    Cell Significance Index: -1.9900
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.3301
    Cell Significance Index: -16.6800
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.3315
    Cell Significance Index: -25.4400
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.3438
    Cell Significance Index: -22.1800
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.3601
    Cell Significance Index: -26.8400
  • Cell Name: hippocampal astrocyte (CL0002604)
    Fold Change: -0.3719
    Cell Significance Index: -5.2000
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.3804
    Cell Significance Index: -17.8800
  • Cell Name: supporting cell (CL0000630)
    Fold Change: -0.4103
    Cell Significance Index: -1.9000
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.4176
    Cell Significance Index: -18.4700
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.4196
    Cell Significance Index: -8.1900
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.4323
    Cell Significance Index: -29.0700
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: -0.5115
    Cell Significance Index: -6.5500
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.5147
    Cell Significance Index: -8.8200
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.5171
    Cell Significance Index: -24.1100
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.5242
    Cell Significance Index: -19.8500
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.6226
    Cell Significance Index: -32.6900
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.6418
    Cell Significance Index: -33.3400
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -0.6729
    Cell Significance Index: -11.6400
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.6899
    Cell Significance Index: -9.8800
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.7045
    Cell Significance Index: -18.8100
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.7178
    Cell Significance Index: -20.0600
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.7222
    Cell Significance Index: -25.3000
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: -0.7265
    Cell Significance Index: -10.1900
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.7391
    Cell Significance Index: -15.7400
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.7434
    Cell Significance Index: -19.1100
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.7488
    Cell Significance Index: -19.6900

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** MYLK is a non-motor protein that belongs to the protein kinase family. It is a dual-specificity kinase, meaning it can phosphorylate both serine and threonine residues on its substrate proteins. The MYLK enzyme exhibits a high degree of specificity, with a preference for phosphorylating the light chain of myosin II, which is a key regulator of actin filament dynamics. MYLK is also activated by calmodulin, a calcium-binding protein that regulates the enzyme's activity in response to changes in intracellular calcium levels. **Pathways and Functions** The MYLK gene is involved in a wide range of cellular processes, including: 1. **Muscle Contraction**: MYLK regulates the contraction of smooth muscle cells by phosphorylating the light chain of myosin II, which leads to the formation of actin-myosin complexes and contraction. 2. **Cell Migration**: MYLK is involved in the regulation of cell migration by phosphorylating proteins that regulate the actin cytoskeleton, such as LIM kinase and paxillin. 3. **Wound Healing**: MYLK plays a crucial role in wound healing by regulating the migration and contraction of smooth muscle cells, which helps to close wounds and restore tissue integrity. 4. **Stress Fiber Formation**: MYLK is involved in the formation of stress fibers, which are actin-rich structures that play a key role in cell migration and contraction. 5. **Cell Signaling**: MYLK is also involved in cell signaling pathways, including the regulation of calcium ion transport and the activation of Rho GTPases. **Clinical Significance** Dysregulation of the MYLK gene has been implicated in various diseases, including: 1. **Atherosclerosis**: MYLK has been shown to play a role in the development of atherosclerosis, a disease characterized by the buildup of plaque in the arteries. 2. **Hypertension**: MYLK has been implicated in the regulation of blood pressure, and its dysregulation has been linked to hypertension. 3. **Cancer**: MYLK has been shown to play a role in the regulation of cell migration and invasion in various types of cancer, including breast and lung cancer. 4. **Neurological Disorders**: MYLK has been implicated in the regulation of neuronal function and has been shown to play a role in the pathogenesis of neurological disorders, including Parkinson's disease and Alzheimer's disease. In conclusion, the MYLK gene plays a critical role in regulating various cellular processes, including muscle contraction, cell migration, wound healing, and stress fiber formation. Its dysregulation has been implicated in various diseases, highlighting the importance of this gene in maintaining normal cellular function and preventing disease.

Genular Protein ID: 3926578674

Symbol: MYLK_HUMAN

Name: Kinase-related protein

UniProtKB Accession Codes:

Q15746 B4DUE3 D3DN97 O95796 O95797 O95798 O95799 Q14844 Q16794 Q17S15 Q3ZCP9 Q5MY99 Q5MYA0 Q6P2N0 Q7Z4J0 Q9C0L5 Q9UBG5 Q9UBY6 Q9UIT9

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 6 CDD 6 CORUM 1 CPTAC 1 CTD 1 ChEBI 14 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 2 DrugCentral 1 EC 2 EMBL 36 Ensembl 13 EvolutionaryTrace 1 ExpressionAtlas 1 GO 21 Gene3D 2 GeneCards 1 GeneReviews 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 GuidetoPHARMACOLOGY 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 14 KEGG 1 MANE-Select 1 MIM 5 MINT 1 MalaCards 1 MassIVE 1 MetOSite 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 2 OrthoDB 1 PANTHER 2 PDB 6 PDBsum 6 PRO 1 PROSITE 5 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 4 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 9 Pumba 1 RNAct 1 Reactome 2 RefSeq 12 Rhea 8 SABIO-RK 1 SIGNOR 1 SMART 4 SMR 1 STRING 1 SUPFAM 3 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8575746

Title: The human myosin light chain kinase (MLCK) from hippocampus: cloning, sequencing, expression, and localization to 3qcen-q21.

PubMed ID: 8575746

DOI: 10.1006/geno.1995.9965

PubMed ID: 9160829

Title: Myosin light chain kinase in endothelium: molecular cloning and regulation.

PubMed ID: 9160829

DOI: 10.1165/ajrcmb.16.5.9160829

PubMed ID: 10198165

Title: A single human myosin light chain kinase gene (MLCK; MYLK).

PubMed ID: 10198165

DOI: 10.1006/geno.1999.5774

PubMed ID: 11113114

Title: Differential regulation of alternatively spliced endothelial cell myosin light chain kinase isoforms by p60(Src).

PubMed ID: 11113114

DOI: 10.1074/jbc.m005270200

PubMed ID: 10536370

Title: Analysis of the kinase-related protein gene found at human chromosome 3q21 in a multi-gene cluster: organization, expression, alternative splicing and polymorphic marker.

PubMed ID: 10536370

DOI: 10.1002/(sici)1097-4644(19991201)75:3<481::aid-jcb12>3.3.co;2-x

PubMed ID: 15507455

Title: A differentiation-dependent splice variant of myosin light chain kinase, MLCK1, regulates epithelial tight junction permeability.

PubMed ID: 15507455

DOI: 10.1074/jbc.m408822200

PubMed ID: 15020676

Title: The N-terminus of the long MLCK induces a disruption in normal spindle morphology and metaphase arrest.

PubMed ID: 15020676

DOI: 10.1242/jcs.00993

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16641997

Title: The DNA sequence, annotation and analysis of human chromosome 3.

PubMed ID: 16641997

DOI: 10.1038/nature04728

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 12408982

Title: Novel interaction of cortactin with endothelial cell myosin light chain kinase.

PubMed ID: 12408982

DOI: 10.1016/s0006-291x(02)02492-0

PubMed ID: 11976941

Title: Myosin light chain kinase modulates hypotonicity-induced Ca2+ entry and Cl- channel activity in human cervical cancer cells.

PubMed ID: 11976941

DOI: 10.1007/s00424-002-0811-3

PubMed ID: 14741352

Title: Quantitative measurements of Ca(2+)/calmodulin binding and activation of myosin light chain kinase in cells.

PubMed ID: 14741352

DOI: 10.1016/s0014-5793(03)01456-x

PubMed ID: 15825080

Title: Distinct temporal-spatial roles for rho kinase and myosin light chain kinase in epithelial purse-string wound closure.

PubMed ID: 15825080

DOI: 10.1053/j.gastro.2005.01.004

PubMed ID: 16835238

Title: Tumor necrosis factor-induced long myosin light chain kinase transcription is regulated by differentiation-dependent signaling events. Characterization of the human long myosin light chain kinase promoter.

PubMed ID: 16835238

DOI: 10.1074/jbc.m602164200

PubMed ID: 16723733

Title: Myosin light chain kinase plays a role in the regulation of epithelial cell survival.

PubMed ID: 16723733

DOI: 10.1242/jcs.02926

PubMed ID: 16284075

Title: Ca2+-calmodulin-dependent myosin light chain kinase is essential for activation of TRPC5 channels expressed in HEK293 cells.

PubMed ID: 16284075

DOI: 10.1113/jphysiol.2005.097998

PubMed ID: 18710790

Title: Myosin light-chain kinase contributes to the proliferation and migration of breast cancer cells through cross-talk with activated ERK1/2.

PubMed ID: 18710790

DOI: 10.1016/j.canlet.2008.05.028

PubMed ID: 18088087

Title: Phosphoproteome of resting human platelets.

PubMed ID: 18088087

DOI: 10.1021/pr0704130

PubMed ID: 18587400

Title: Nonmuscle myosin light-chain kinase mediates neutrophil transmigration in sepsis-induced lung inflammation by activating beta2 integrins.

PubMed ID: 18587400

DOI: 10.1038/ni.1628

PubMed ID: 18318008

Title: Large-scale phosphoproteome analysis of human liver tissue by enrichment and fractionation of phosphopeptides with strong anion exchange chromatography.

PubMed ID: 18318008

DOI: 10.1002/pmic.200700884

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 19429448

Title: Androgens down-regulate myosin light chain kinase in human prostate cancer cells.

PubMed ID: 19429448

DOI: 10.1016/j.jsbmb.2009.02.002

PubMed ID: 19826488

Title: Arrest defective-1 controls tumor cell behavior by acetylating myosin light chain kinase.

PubMed ID: 19826488

DOI: 10.1371/journal.pone.0007451

PubMed ID: 20453870

Title: Myosin light chain kinase is responsible for high proliferative ability of breast cancer cells via anti-apoptosis involving p38 pathway.

PubMed ID: 20453870

DOI: 10.1038/aps.2010.56

PubMed ID: 20375339

Title: Modulation of factors affecting optic nerve head astrocyte migration.

PubMed ID: 20375339

DOI: 10.1167/iovs.10-5177

PubMed ID: 20053363

Title: Quantitative distribution and colocalization of non-muscle myosin light chain kinase isoforms and cortactin in human lung endothelium.

PubMed ID: 20053363

DOI: 10.1016/j.mvr.2009.12.010

PubMed ID: 20861316

Title: Abl tyrosine kinase phosphorylates nonmuscle Myosin light chain kinase to regulate endothelial barrier function.

PubMed ID: 20861316

DOI: 10.1091/mbc.e09-10-0876

PubMed ID: 20181817

Title: The angiotensin II type 1 receptor induces membrane blebbing by coupling to Rho A, Rho kinase, and myosin light chain kinase.

PubMed ID: 20181817

DOI: 10.1124/mol.110.063859

PubMed ID: 20139351

Title: Non-muscle myosin light chain kinase isoform is a viable molecular target in acute inflammatory lung injury.

PubMed ID: 20139351

DOI: 10.1165/rcmb.2009-0197oc

PubMed ID: 21918590

Title: Organometallic pyridylnaphthalimide complexes as protein kinase inhibitors.

PubMed ID: 21918590

DOI: 10.1021/om200366r

PubMed ID: 19011151

Title: Myosin, transgelin, and myosin light chain kinase: expression and function in asthma.

PubMed ID: 19011151

DOI: 10.1164/rccm.200609-1367oc

PubMed ID: 22015949

Title: An intronic MYLK variant associated with inflammatory lung disease regulates promoter activity of the smooth muscle myosin light chain kinase isoform.

PubMed ID: 22015949

DOI: 10.1007/s00109-011-0820-9

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 18462678

Title: A coupled equilibrium shift mechanism in calmodulin-mediated signal transduction.

PubMed ID: 18462678

DOI: 10.1016/j.str.2008.02.017

PubMed ID: 17344846

Title: Patterns of somatic mutation in human cancer genomes.

PubMed ID: 17344846

DOI: 10.1038/nature05610

PubMed ID: 21055718

Title: Mutations in myosin light chain kinase cause familial aortic dissections.

PubMed ID: 21055718

DOI: 10.1016/j.ajhg.2010.10.006

PubMed ID: 28401540

Title: Two novel MYLK nonsense mutations causing thoracic aortic aneurysms/dissections in patients without apparent family history.

PubMed ID: 28401540

DOI: 10.1111/cge.13000

PubMed ID: 29537095

Title:

PubMed ID: 29537095

DOI: 10.1111/cge.13213

PubMed ID: 29544503

Title: Fatal thoracic aortic aneurysm and dissection in a large family with a novel MYLK gene mutation: delineation of the clinical phenotype.

PubMed ID: 29544503

DOI: 10.1186/s13023-018-0769-7

PubMed ID: 28602422

Title: Loss-of-Function Variants in MYLK Cause Recessive Megacystis Microcolon Intestinal Hypoperistalsis Syndrome.

PubMed ID: 28602422

DOI: 10.1016/j.ajhg.2017.05.011

Sequence Information:

  • Length: 1914
  • Mass: 210715
  • Checksum: 2D094E161CE2D4BA
  • Sequence:
    • MGDVKLVASS HISKTSLSVD PSRVDSMPLT EAPAFILPPR NLCIKEGATA KFEGRVRGYP 
EPQVTWHRNG QPITSGGRFL LDCGIRGTFS LVIHAVHEED RGKYTCEATN GSGARQVTVE 
LTVEGSFAKQ LGQPVVSKTL GDRFSAPAVE TRPSIWGECP PKFATKLGRV VVKEGQMGRF 
SCKITGRPQP QVTWLKGNVP LQPSARVSVS EKNGMQVLEI HGVNQDDVGV YTCLVVNGSG 
KASMSAELSI QGLDSANRSF VRETKATNSD VRKEVTNVIS KESKLDSLEA AAKSKNCSSP 
QRGGSPPWAA NSQPQPPRES KLESCKDSPR TAPQTPVLQK TSSSITLQAA RVQPEPRAPG 
LGVLSPSGEE RKRPAPPRPA TFPTRQPGLG SQDVVSKAAN RRIPMEGQRD SAFPKFESKP 
QSQEVKENQT VKFRCEVSGI PKPEVAWFLE GTPVRRQEGS IEVYEDAGSH YLCLLKARTR 
DSGTYSCTAS NAQGQLSCSW TLQVERLAVM EVAPSFSSVL KDCAVIEGQD FVLQCSVRGT 
PVPRITWLLN GQPIQYARST CEAGVAELHI QDALPEDHGT YTCLAENALG QVSCSAWVTV 
HEKKSSRKSE YLLPVAPSKP TAPIFLQGLS DLKVMDGSQV TMTVQVSGNP PPEVIWLHNG 
NEIQESEDFH FEQRGTQHSL CIQEVFPEDT GTYTCEAWNS AGEVRTQAVL TVQEPHDGTQ 
PWFISKPRSV TASLGQSVLI SCAIAGDPFP TVHWLRDGKA LCKDTGHFEV LQNEDVFTLV 
LKKVQPWHAG QYEILLKNRV GECSCQVSLM LQNSSARALP RGREPASCED LCGGGVGADG 
GGSDRYGSLR PGWPARGQGW LEEEDGEDVR GVLKRRVETR QHTEEAIRQQ EVEQLDFRDL 
LGKKVSTKTL SEDDLKEIPA EQMDFRANLQ RQVKPKTVSE EERKVHSPQQ VDFRSVLAKK 
GTSKTPVPEK VPPPKPATPD FRSVLGGKKK LPAENGSSSA ETLNAKAVES SKPLSNAQPS 
GPLKPVGNAK PAETLKPMGN AKPAETLKPM GNAKPDENLK SASKEELKKD VKNDVNCKRG 
HAGTTDNEKR SESQGTAPAF KQKLQDVHVA EGKKLLLQCQ VSSDPPATII WTLNGKTLKT 
TKFIILSQEG SLCSVSIEKA LPEDRGLYKC VAKNDAGQAE CSCQVTVDDA PASENTKAPE 
MKSRRPKSSL PPVLGTESDA TVKKKPAPKT PPKAAMPPQI IQFPEDQKVR AGESVELFGK 
VTGTQPITCT WMKFRKQIQE SEHMKVENSE NGSKLTILAA RQEHCGCYTL LVENKLGSRQ 
AQVNLTVVDK PDPPAGTPCA SDIRSSSLTL SWYGSSYDGG SAVQSYSIEI WDSANKTWKE 
LATCRSTSFN VQDLLPDHEY KFRVRAINVY GTSEPSQESE LTTVGEKPEE PKDEVEVSDD 
DEKEPEVDYR TVTINTEQKV SDFYDIEERL GSGKFGQVFR LVEKKTRKVW AGKFFKAYSA 
KEKENIRQEI SIMNCLHHPK LVQCVDAFEE KANIVMVLEI VSGGELFERI IDEDFELTER 
ECIKYMRQIS EGVEYIHKQG IVHLDLKPEN IMCVNKTGTR IKLIDFGLAR RLENAGSLKV 
LFGTPEFVAP EVINYEPIGY ATDMWSIGVI CYILVSGLSP FMGDNDNETL ANVTSATWDF 
DDEAFDEISD DAKDFISNLL KKDMKNRLDC TQCLQHPWLM KDTKNMEAKK LSKDRMKKYM 
ARRKWQKTGN AVRAIGRLSS MAMISGLSGR KSSTGSPTSP LNAEKLESEE DVSQAFLEAV 
AEEKPHVKPY FSKTIRDLEV VEGSAARFDC KIEGYPDPEV VWFKDDQSIR ESRHFQIDYD 
EDGNCSLIIS DVCGDDDAKY TCKAVNSLGE ATCTAELIVE TMEEGEGEGE EEEE

Genular Protein ID: 853083194

Symbol: A0A8I5KTQ1_HUMAN

Name: N/A

UniProtKB Accession Codes:

A0A8I5KTQ1

Database IDs:

ARBA 6 CDD 3 CTD 1 ChEBI 1 DisGeNET 1 EMBL 3 Ensembl 2 GO 2 Gene3D 2 GeneTree 1 HGNC 1 InterPro 13 NCBI Taxonomy 1 PANTHER 2 PRINTS 1 PROSITE 8 PROSITE-ProRule 1 PeptideAtlas 2 Pfam 3 Proteomes 2 ProteomicsDB 1 RefSeq 1 SAM 1 SMART 4 SMR 1 SUPFAM 3

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

PubMed ID: 16641997

Title: The DNA sequence, annotation and analysis of human chromosome 3.

PubMed ID: 16641997

DOI: 10.1038/nature04728

Sequence Information:

  • Length: 713
  • Mass: 80281
  • Checksum: 9AF4EFA4A5F0DC15
  • Sequence:
    • MKSRRPKSSL PPVLGTESDA TVKKKPAPKT PPKAAMPPQI IQFPEDQKVR AGESVELFGK 
VTGTQPITCT WMKFRKQIQE SEHMKVENSE NGSKLTILAA RQEHCGCYTL LVENKLGSRQ 
AQVNLTVVDK PDPPAGTPCA SDIRSSSLTL SWYGSSYDGG SAVQSYSIEI WDSANKTWKE 
LATCRSTSFN VQDLLPDHEY KFRVRAINVY GTSEPSQESE LTTVGEKPEE PKDEVEVSDD 
DEKEPEVDYR TVTINTEQKV SDFYDIEERL GSGKFGQVFR LVEKKTRKVW AGKFFKAYSA 
KEKENIRQEI SIMNCLHHPK LVQCVDAFEE KANIVMVLEI VSGGELFERI IDEDFELTER 
ECIKYMRQIS EGVEYIHKQG IVHLDLKPEN IMCVNKTGTR IKLIDFGLAR RLENAGSLKV 
LFGTPEFVAP EVINYEPIGY ATDMWSIGVI CYILVSGLSP FMGDNDNETL ANVTSATWDF 
DDEAFDEISD DAKDFISNLL KKDMKNRLDC TQCLQHPWLM KDTKNMEAKK LSKDRMKKYM 
ARRKWQKTGN AVRAIGRLSS MAMISGLSGR KSSTGSPTSP LNAEKLESED VSQAFLEAVA 
EEKPHVKPYF SKTIRDLEVV EGSAARFDCK IEGYPDPEVV WFKDDQSIRE SRHFQIDYDE 
DGNCSLIISD VCGDDDAKYT CKAVNSLGEA TCTAELIVET MEEGEGEGEE EEE

Genular Protein ID: 2237248743

Symbol: Q05B97_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q05B97

Database IDs:

AlphaFoldDB 1 BioGRID-ORCS 1 CDD 1 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 2 GO 6 Gene3D 1 InterPro 7 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PROSITE 2 PeptideAtlas 1 Pfam 1 RefSeq 2 SAM 1 SMART 2 SUPFAM 1

Citations:

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 166
  • Mass: 18152
  • Checksum: 530910BA7C1C9066
  • Sequence:
    • GNAVRAIGRL SSMAMISGLS GRKSSTGSPT SPLNAEKLES EEDVSQAFLE AVAEEKPHVK 
PYFSKTIRDL EVVEGSAARF DCKIEGYPDP EVVWFKDDQS IRESRHFQID YDEDGNCSLI 
ISDVCGDDDA KYTCKAVNSL GEATCTAELI VETMEEGEGE GEEEEE

Genular Protein ID: 1949847334

Symbol: Q05B98_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q05B98

Database IDs:

AlphaFoldDB 1 BioGRID-ORCS 1 CDD 1 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 2 GO 6 Gene3D 1 InterPro 7 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PROSITE 2 PeptideAtlas 1 Pfam 1 RefSeq 1 SAM 1 SMART 2 SUPFAM 1

Citations:

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 167
  • Mass: 18253
  • Checksum: 4727D0FE381CA2F9
  • Sequence:
    • TGNAVRAIGR LSSMAMISGL SGRKSSTGSP TSPLNAEKLE SEEDVSQAFL EAVAEEKPHV 
KPYFSKTIRD LEVVEGSAAR FDCKIEGYPD PEVVWFKDDQ SIRESRHFQI DYDEDGNCSL 
IISDVCGDDD AKYTCKAVNS LGEATCTAEL IVETMEEGEG EGEEEEE

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.