Details for: LMCD1

Gene ID: 29995

Symbol: LMCD1

Ensembl ID: ENSG00000071282

Description: LIM and cysteine rich domains 1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 186.4410
    Cell Significance Index: -29.0000
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 116.1473
    Cell Significance Index: -29.4600
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 59.6137
    Cell Significance Index: -28.1500
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 55.8759
    Cell Significance Index: -22.7000
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 42.2713
    Cell Significance Index: -28.3700
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 23.7237
    Cell Significance Index: -22.6500
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 23.5613
    Cell Significance Index: -29.0500
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 9.3759
    Cell Significance Index: -20.5200
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: 7.8162
    Cell Significance Index: 128.8000
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: 7.7770
    Cell Significance Index: 189.7600
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 7.3669
    Cell Significance Index: -29.0700
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 6.3618
    Cell Significance Index: -19.5400
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 5.6691
    Cell Significance Index: 100.1800
  • Cell Name: type II muscle cell (CL0002212)
    Fold Change: 4.0464
    Cell Significance Index: 65.2900
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 2.9638
    Cell Significance Index: 33.6700
  • Cell Name: adipocyte of breast (CL0002617)
    Fold Change: 1.8226
    Cell Significance Index: 22.9500
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 1.3410
    Cell Significance Index: 38.4400
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.2989
    Cell Significance Index: 128.4900
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 1.0888
    Cell Significance Index: 983.1400
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.9845
    Cell Significance Index: 14.1600
  • Cell Name: subcutaneous adipocyte (CL0002521)
    Fold Change: 0.9051
    Cell Significance Index: 3.9400
  • Cell Name: peg cell (CL4033014)
    Fold Change: 0.8999
    Cell Significance Index: 20.7900
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.8944
    Cell Significance Index: 122.8200
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.8763
    Cell Significance Index: 387.4500
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.8049
    Cell Significance Index: 61.7700
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.6640
    Cell Significance Index: 108.0000
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 0.6575
    Cell Significance Index: 8.4200
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.6331
    Cell Significance Index: 29.5200
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.5618
    Cell Significance Index: 29.2700
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.4762
    Cell Significance Index: 51.8000
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.3666
    Cell Significance Index: 27.3200
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.3494
    Cell Significance Index: 40.7200
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.3444
    Cell Significance Index: 468.2900
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.3155
    Cell Significance Index: 62.6100
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 0.2747
    Cell Significance Index: 4.2500
  • Cell Name: endothelial cell of uterus (CL0009095)
    Fold Change: 0.2220
    Cell Significance Index: 1.3900
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: 0.2152
    Cell Significance Index: 1.3000
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.2116
    Cell Significance Index: 40.2700
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.1952
    Cell Significance Index: 13.5000
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.1922
    Cell Significance Index: 354.3800
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.1863
    Cell Significance Index: 286.7600
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.1093
    Cell Significance Index: 14.0100
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.1081
    Cell Significance Index: 3.1200
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.0615
    Cell Significance Index: 3.6900
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.0386
    Cell Significance Index: 1.7500
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 0.0354
    Cell Significance Index: 4.0500
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0306
    Cell Significance Index: 1.0800
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.0192
    Cell Significance Index: 2.2700
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.0160
    Cell Significance Index: 0.4000
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.0096
    Cell Significance Index: 5.2500
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.0069
    Cell Significance Index: 0.1500
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0015
    Cell Significance Index: -1.1400
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0053
    Cell Significance Index: -0.6500
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0095
    Cell Significance Index: -5.9400
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0146
    Cell Significance Index: -27.5200
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0156
    Cell Significance Index: -2.6600
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: -0.0229
    Cell Significance Index: -15.8500
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0257
    Cell Significance Index: -3.3200
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0266
    Cell Significance Index: -0.4500
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0276
    Cell Significance Index: -17.5300
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0322
    Cell Significance Index: -23.6400
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0326
    Cell Significance Index: -24.6700
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0336
    Cell Significance Index: -18.9500
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0342
    Cell Significance Index: -6.1600
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0508
    Cell Significance Index: -14.6200
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0620
    Cell Significance Index: -22.2500
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0636
    Cell Significance Index: -28.8500
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0695
    Cell Significance Index: -13.9500
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0800
    Cell Significance Index: -16.8400
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0843
    Cell Significance Index: -2.2500
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.1119
    Cell Significance Index: -11.4300
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.1297
    Cell Significance Index: -18.8600
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.1409
    Cell Significance Index: -2.7500
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.1752
    Cell Significance Index: -8.8500
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.1842
    Cell Significance Index: -21.0300
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.2161
    Cell Significance Index: -15.2900
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.2463
    Cell Significance Index: -12.9300
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: -0.2464
    Cell Significance Index: -2.0700
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.2598
    Cell Significance Index: -8.3200
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.2832
    Cell Significance Index: -13.3100
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.2843
    Cell Significance Index: -29.6100
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.2857
    Cell Significance Index: -6.0900
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.3179
    Cell Significance Index: -25.1800
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.3308
    Cell Significance Index: -20.8500
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.3498
    Cell Significance Index: -23.5200
  • Cell Name: perivascular cell (CL4033054)
    Fold Change: -0.3855
    Cell Significance Index: -1.7800
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.3944
    Cell Significance Index: -24.1800
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.4035
    Cell Significance Index: -8.4500
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.4150
    Cell Significance Index: -6.1300
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.4315
    Cell Significance Index: -27.8400
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.4332
    Cell Significance Index: -11.3900
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.4393
    Cell Significance Index: -12.9400
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: -0.4741
    Cell Significance Index: -6.6500
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.4821
    Cell Significance Index: -29.6300
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.4844
    Cell Significance Index: -27.1800
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.4920
    Cell Significance Index: -14.0400
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.5223
    Cell Significance Index: -18.1500
  • Cell Name: embryonic fibroblast (CL2000042)
    Fold Change: -0.5268
    Cell Significance Index: -2.5200
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.5271
    Cell Significance Index: -14.7300
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.5277
    Cell Significance Index: -14.1400

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** LMCD1 is a member of the LIM-only and cysteine-rich domains family of proteins, characterized by the presence of two distinct domains: LIM and cysteine-rich. These domains are thought to be involved in protein-protein interactions, protein binding, and regulation of transcription. The gene's expression pattern, which is widespread across various cell types, suggests that LMCD1 plays a multifunctional role in cellular processes. The gene's involvement in negative regulation of transcription by RNA polymerase II and positive regulation of the calcineurin-NFAT signaling cascade highlights its potential role in modulating gene expression and cell signaling pathways. **Pathways and Functions:** LMCD1 is involved in several cellular pathways, including: 1. **Metabolism of proteins**: LMCD1 is thought to play a role in regulating protein metabolism, including protein degradation and synthesis. 2. **Negative regulation of transcription by RNA polymerase II**: LMCD1 acts as a transcription corepressor, regulating the expression of genes involved in various cellular processes. 3. **Positive regulation of calcineurin-NFAT signaling cascade**: LMCD1 is involved in the activation of this signaling cascade, which is critical for cell growth, differentiation, and survival. 4. **Regulation of cardiac muscle hypertrophy**: LMCD1 is implicated in the regulation of cardiac muscle hypertrophy, a condition characterized by the abnormal growth of cardiac muscle cells. 5. **Surfactant metabolism**: LMCD1 is involved in the regulation of surfactant metabolism, which is critical for maintaining lung function and preventing respiratory distress syndrome. **Clinical Significance:** LMCD1's involvement in various cellular processes and pathways highlights its potential role in maintaining cellular homeostasis and overall health. Abnormal expression or function of LMCD1 has been implicated in several diseases, including: 1. **Cardiac hypertrophy**: LMCD1's role in regulating cardiac muscle hypertrophy makes it a potential therapeutic target for the treatment of this condition. 2. **Respiratory diseases**: LMCD1's involvement in surfactant metabolism and regulation of lung function makes it a potential therapeutic target for the treatment of respiratory diseases, such as respiratory distress syndrome. 3. **Cancer**: LMCD1's role in regulating cell growth and differentiation makes it a potential therapeutic target for the treatment of cancer. In conclusion, LMCD1 is a multifunctional gene that plays a crucial role in various cellular processes and pathways. Its involvement in disease mechanisms highlights its potential as a therapeutic target for the treatment of various diseases. Further research is necessary to fully understand the functions and clinical significance of LMCD1.

Genular Protein ID: 433959511

Symbol: LMCD1_HUMAN

Name: LIM and cysteine-rich domains protein 1

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 10662546

Title: Identification of a novel LIM domain gene, LMCD1, and chromosomal localization in human and mouse.

PubMed ID: 10662546

DOI: 10.1006/geno.1999.6049

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16641997

Title: The DNA sequence, annotation and analysis of human chromosome 3.

PubMed ID: 16641997

DOI: 10.1038/nature04728

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 16199866

Title: LMCD1/Dyxin is a novel transcriptional cofactor that restricts GATA6 function by inhibiting DNA binding.

PubMed ID: 16199866

DOI: 10.1128/mcb.25.20.8864-8873.2005

PubMed ID: 20026769

Title: LIM and cysteine-rich domains 1 regulates cardiac hypertrophy by targeting calcineurin/nuclear factor of activated T cells signaling.

PubMed ID: 20026769

DOI: 10.1161/hypertensionaha.109.135665

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

Sequence Information:

  • Length: 365
  • Mass: 40833
  • Checksum: D84BFD53C43D2DD7
  • Sequence:
  • MAKVAKDLNP GVKKMSLGQL QSARGVACLG CKGTCSGFEP HSWRKICKSC KCSQEDHCLT 
    SDLEDDRKIG RLLMDSKYST LTARVKGGDG IRIYKRNRMI MTNPIATGKD PTFDTITYEW 
    APPGVTQKLG LQYMELIPKE KQPVTGTEGA FYRRRQLMHQ LPIYDQDPSR CRGLLENELK 
    LMEEFVKQYK SEALGVGEVA LPGQGGLPKE EGKQQEKPEG AETTAATTNG SLSDPSKEVE 
    YVCELCKGAA PPDSPVVYSD RAGYNKQWHP TCFVCAKCSE PLVDLIYFWK DGAPWCGRHY 
    CESLRPRCSG CDEIIFAEDY QRVEDLAWHR KHFVCEGCEQ LLSGRAYIVT KGQLLCPTCS 
    KSKRS

Genular Protein ID: 1873697689

Symbol: B7Z6R5_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Sequence Information:

  • Length: 240
  • Mass: 26585
  • Checksum: D47ECDD99B549D57
  • Sequence:
  • MAKVAKDLNP GVKKMSLGQL QSARGVACLG CKGTCSGFEP HSWRKICKSC KCSQEDHCLT 
    SDLEDDRKIG RLLMDSKYST LTARVKGGDG IRIYKRNRMI MTNPIATGKD PTFDTITITQ 
    KLGLQYMELI PKEKQPVTGT EGAFYRRRQL MHQLPIYDQD PSRCRGLLEN ELKLMEEFVK 
    QYKSEALGVG EVALPGQGGL PKEEGKQQEK PEGAETTAAT TNGSLSDPSK EVEYKPVPLV

Genular Protein ID: 2278534534

Symbol: B4DEY6_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

PubMed ID: 16641997

Title: The DNA sequence, annotation and analysis of human chromosome 3.

PubMed ID: 16641997

DOI: 10.1038/nature04728

Sequence Information:

  • Length: 253
  • Mass: 28513
  • Checksum: 4688E5A11A609081
  • Sequence:
  • MFGMQGDVFG LRATFMEGLQ YMELIPKEKQ PVTGTEGAFY RRRQLMHQLP IYDQDPSRCR 
    GLLENELKLM EEFVKQYKSE ALGVGEVALP GQGGLPKEEG KQQEKPEGAE TTAATTNGSL 
    SDPSKEVEYV CELCKGAAPP DSPVVYSDRA GYNKQWHPTC FVCAKCSEPL VDLIYFWKDG 
    APWCGRHYCE SLRPRCSGCD EIIFAEDYQR VEDLAWHRKH FVCEGCEQLL SGRAYIVTKG 
    QLLCPTCSKS KRS

Genular Protein ID: 857650065

Symbol: H7C3D2_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

PubMed ID: 16641997

Title: The DNA sequence, annotation and analysis of human chromosome 3.

PubMed ID: 16641997

DOI: 10.1038/nature04728

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

Sequence Information:

  • Length: 247
  • Mass: 27371
  • Checksum: 8E97A0D7BA2AA486
  • Sequence:
  • MAKVAKDLNP GVKKMSLGQL QSARGVACLG CKGTCSGFEP HSWRKICKSC KCSQEDHCLT 
    SDLEDDRKIG RLLMDSKYST LTARVKGGDG IRIYKRNRMI MTNPIATGKD PTFDTITYEW 
    APPGVTQKLG LQYMELIPKE KQPVTGTEGA FYRRRQLMHQ LPIYDQDPSR CRGLLENELK 
    LMEEFVKQYK SEALGVGEVA LPGQGGLPKE EGKQQEKPEG AETTAATTNG SLSDPSKEVE 
    YKPVPLV

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.