Details for: HPGD

Gene ID: 3248

Symbol: HPGD

Ensembl ID: ENSG00000164120

Description: 15-hydroxyprostaglandin dehydrogenase

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 99.1994
    Cell Significance Index: -15.4300
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 56.6149
    Cell Significance Index: -14.3600
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 34.8003
    Cell Significance Index: -16.4300
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 34.3871
    Cell Significance Index: -13.9700
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 24.4254
    Cell Significance Index: -16.3900
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 15.8577
    Cell Significance Index: -15.1400
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: 15.8108
    Cell Significance Index: 98.2400
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 12.5146
    Cell Significance Index: -15.4300
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 11.8060
    Cell Significance Index: 614.9600
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 9.1169
    Cell Significance Index: 83.9600
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 8.2886
    Cell Significance Index: 222.1000
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 8.0827
    Cell Significance Index: 419.8700
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 6.0399
    Cell Significance Index: -16.1800
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 4.1762
    Cell Significance Index: -9.1400
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 3.9923
    Cell Significance Index: 719.6900
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 3.4078
    Cell Significance Index: 73.8300
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 3.1272
    Cell Significance Index: -9.6100
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 2.6958
    Cell Significance Index: 45.4100
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 2.3231
    Cell Significance Index: 62.0300
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: 2.2345
    Cell Significance Index: 18.4800
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 2.2296
    Cell Significance Index: 274.1500
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 1.9505
    Cell Significance Index: 137.9500
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 1.7756
    Cell Significance Index: 193.1300
  • Cell Name: taste receptor cell (CL0000209)
    Fold Change: 1.5093
    Cell Significance Index: 17.5500
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 1.2895
    Cell Significance Index: 37.8700
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 1.1445
    Cell Significance Index: 32.9800
  • Cell Name: tuft cell of small intestine (CL0009080)
    Fold Change: 1.0364
    Cell Significance Index: 10.4600
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.9430
    Cell Significance Index: 851.4200
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.8978
    Cell Significance Index: 62.0900
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 0.8869
    Cell Significance Index: 13.2900
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: 0.8356
    Cell Significance Index: 95.3800
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.8313
    Cell Significance Index: 20.7800
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.6955
    Cell Significance Index: 7.2000
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.6556
    Cell Significance Index: 29.7200
  • Cell Name: alveolar capillary type 2 endothelial cell (CL4028003)
    Fold Change: 0.4207
    Cell Significance Index: 2.7300
  • Cell Name: epithelial cell of urethra (CL1000296)
    Fold Change: 0.3312
    Cell Significance Index: 2.0500
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.2789
    Cell Significance Index: 5.9400
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: 0.2686
    Cell Significance Index: 1.8200
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: 0.2371
    Cell Significance Index: 3.5000
  • Cell Name: pulmonary capillary endothelial cell (CL4028001)
    Fold Change: 0.2198
    Cell Significance Index: 3.0100
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.2035
    Cell Significance Index: 20.1400
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.1880
    Cell Significance Index: 83.1400
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.1866
    Cell Significance Index: 35.5100
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.1378
    Cell Significance Index: 3.8500
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.1244
    Cell Significance Index: 4.3700
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.0959
    Cell Significance Index: 66.3600
  • Cell Name: colonocyte (CL1000347)
    Fold Change: 0.0825
    Cell Significance Index: 0.5100
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.0446
    Cell Significance Index: 2.6800
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0341
    Cell Significance Index: 64.2900
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.0146
    Cell Significance Index: 1.0900
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: 0.0005
    Cell Significance Index: 0.0200
  • Cell Name: epidermal cell (CL0000362)
    Fold Change: 0.0000
    Cell Significance Index: 0.0000
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0042
    Cell Significance Index: -2.6200
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0104
    Cell Significance Index: -5.8400
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0106
    Cell Significance Index: -19.4900
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0111
    Cell Significance Index: -8.1900
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0117
    Cell Significance Index: -8.5700
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0120
    Cell Significance Index: -5.4600
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0125
    Cell Significance Index: -19.2000
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0141
    Cell Significance Index: -19.2000
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0150
    Cell Significance Index: -11.3200
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.0167
    Cell Significance Index: -0.5400
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0211
    Cell Significance Index: -13.4300
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0233
    Cell Significance Index: -6.6900
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0295
    Cell Significance Index: -16.1100
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0347
    Cell Significance Index: -12.4300
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0362
    Cell Significance Index: -4.2200
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0382
    Cell Significance Index: -8.0400
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0394
    Cell Significance Index: -7.9100
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: -0.0414
    Cell Significance Index: -0.6400
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0429
    Cell Significance Index: -7.3300
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0473
    Cell Significance Index: -4.9300
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0601
    Cell Significance Index: -7.7100
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0603
    Cell Significance Index: -6.1600
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0620
    Cell Significance Index: -8.5100
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0661
    Cell Significance Index: -13.1200
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0724
    Cell Significance Index: -10.5200
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0731
    Cell Significance Index: -8.3800
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.1268
    Cell Significance Index: -14.9500
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.1280
    Cell Significance Index: -10.1400
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.1313
    Cell Significance Index: -16.9700
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.1531
    Cell Significance Index: -6.2700
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.1589
    Cell Significance Index: -4.0600
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.1701
    Cell Significance Index: -8.9300
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.1752
    Cell Significance Index: -10.7400
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.1871
    Cell Significance Index: -5.5100
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.1957
    Cell Significance Index: -3.2800
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.2006
    Cell Significance Index: -15.3900
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.2079
    Cell Significance Index: -12.7800
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.2105
    Cell Significance Index: -5.7300
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.2184
    Cell Significance Index: -2.9800
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: -0.2380
    Cell Significance Index: -3.4100
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.2448
    Cell Significance Index: -16.4600
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.2562
    Cell Significance Index: -16.5300
  • Cell Name: melanocyte (CL0000148)
    Fold Change: -0.2764
    Cell Significance Index: -2.5900
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.2786
    Cell Significance Index: -6.1000
  • Cell Name: syncytiotrophoblast cell (CL0000525)
    Fold Change: -0.2864
    Cell Significance Index: -2.7200
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.2911
    Cell Significance Index: -13.6800
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.2969
    Cell Significance Index: -16.6600
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.3038
    Cell Significance Index: -7.8100

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** HPGD is a multifunctional enzyme that exhibits a wide range of substrate specificities, including prostaglandin E2 (PGE2), prostaglandin I2 (PGI2), and thromboxane A2 (TXA2). The enzyme is also involved in the metabolism of other eicosanoids, such as leukotrienes and lipoxins. HPGD is a NAD+ (nicotinamide adenine dinucleotide) dependent enzyme, meaning that it requires NAD+ as a cofactor to catalyze its reactions. The enzyme is expressed in various tissues, including the lung, adrenal gland, stomach, and bladder, and is also present on the surface of certain cells, such as basophils and macrophages. **Pathways and Functions** HPGD is involved in several key pathways, including: 1. **Prostaglandin catabolic pathway**: HPGD catalyzes the oxidative dehydrogenation of 15-PGIP, leading to the formation of 15-KPGIP, which is a potent inhibitor of prostaglandin-mediated signaling. 2. **Arachidonic acid metabolism**: HPGD is involved in the metabolism of arachidonic acid, a polyunsaturated fatty acid that is converted into various eicosanoids, including prostaglandins, leukotrienes, and lipoxins. 3. **Lipoxygenase pathway**: HPGD is also involved in the lipoxygenase pathway, which is a series of reactions that convert arachidonic acid into leukotrienes. 4. **Biosynthesis of specialized proresolving mediators (SPMs)**: HPGD is involved in the biosynthesis of SPMs, which are a family of anti-inflammatory compounds that are derived from arachidonic acid. **Clinical Significance** HPGD has several clinical implications, including: 1. **Inflammatory diseases**: HPGD has been implicated in the pathogenesis of various inflammatory diseases, including atherosclerosis, hypertension, and inflammatory bowel disease. 2. **Thrombosis**: HPGD has been shown to play a role in the regulation of thrombosis, and its inhibitors have been investigated as potential therapeutic agents for the treatment of cardiovascular disease. 3. **Cancer**: HPGD has been implicated in the regulation of cancer cell growth and metastasis, and its inhibitors have been investigated as potential therapeutic agents for the treatment of cancer. 4. **Reproductive diseases**: HPGD has been implicated in the regulation of reproductive diseases, including preterm labor and parturition. In conclusion, HPGD is a multifunctional enzyme that plays a crucial role in the metabolism of prostaglandins and other eicosanoids. Its clinical significance is evident in its involvement in various physiological and pathological processes, including inflammation, thrombosis, and cancer. Further research is needed to fully understand the role of HPGD in these processes and to develop effective therapeutic strategies for the treatment of diseases associated with HPGD dysfunction.

Genular Protein ID: 3871557081

Symbol: PGDH_HUMAN

Name: Eicosanoid/docosanoid dehydrogenase [NAD(+)]

UniProtKB Accession Codes:

P15428 B4DTA4 B4DU74 B4DV57 D3DP43 E7EV11 O00749 Q06F08 Q12998

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 2 Bgee 1 BindingDB 1 BioCyc 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 5 CDD 1 CTD 1 ChEBI 71 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 2 EC 2 EMBL 16 EMDB 3 Ensembl 6 EvolutionaryTrace 1 ExpressionAtlas 1 GO 27 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GuidetoPHARMACOLOGY 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MIM 6 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 3 OrthoDB 1 PANTHER 2 PDB 4 PDBsum 4 PIR 1 PRINTS 2 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 5 Pumba 1 RNAct 1 Reactome 4 RefSeq 6 Rhea 26 SABIO-RK 1 SIGNOR 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissLipids 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 2337593

Title: Purification and structural characterization of placental NAD(+)-linked 15-hydroxyprostaglandin dehydrogenase. The primary structure reveals the enzyme to belong to the short-chain alcohol dehydrogenase family.

PubMed ID: 2337593

DOI: 10.1021/bi00455a021

PubMed ID: 1697582

Title: Cloning and sequence analysis of the cDNA for human placental NAD(+)-dependent 15-hydroxyprostaglandin dehydrogenase.

PubMed ID: 1697582

DOI: 10.1016/s0021-9258(18)77199-8

PubMed ID: 7557451

Title: Sequence of a novel mRNA coding for a C-terminal-truncated form of human NAD(+)-dependent 15-hydroxyprostaglandin dehydrogenase.

PubMed ID: 7557451

DOI: 10.1016/0378-1119(95)00319-2

PubMed ID: 9099873

Title: Cloning and sequencing of a new 15-hydroxyprostaglandin dehydrogenase related mRNA.

PubMed ID: 9099873

DOI: 10.1016/s0378-1119(96)00800-1

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15815621

Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.

PubMed ID: 15815621

DOI: 10.1038/nature03466

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 2025296

Title: Site-directed mutagenesis of the conserved tyrosine 151 of human placental NAD(+)-dependent 15-hydroxyprostaglandin dehydrogenase yields a catalytically inactive enzyme.

PubMed ID: 2025296

DOI: 10.1016/s0006-291x(05)80262-1

PubMed ID: 8086429

Title: Bacterial expression and site-directed mutagenesis of two critical residues (tyrosine-151 and lysine-155) of human placental NAD(+)-dependent 15-hydroxyprostaglandin dehydrogenase.

PubMed ID: 8086429

DOI: 10.1016/0167-4838(94)90172-4

PubMed ID: 10837478

Title: Oxidoreductases in lipoxin A4 metabolic inactivation: a novel role for 15-onoprostaglandin 13-reductase/leukotriene B4 12-hydroxydehydrogenase in inflammation.

PubMed ID: 10837478

DOI: 10.1074/jbc.m002863200

PubMed ID: 12788907

Title: Mechanism of cortisol/progesterone antagonism in the regulation of 15-hydroxyprostaglandin dehydrogenase activity and messenger ribonucleic acid levels in human chorion and placental trophoblast cells at term.

PubMed ID: 12788907

DOI: 10.1210/jc.2002-021710

PubMed ID: 15044627

Title: The two-step model of prostaglandin signal termination: in vitro reconstitution with the prostaglandin transporter and prostaglandin 15 dehydrogenase.

PubMed ID: 15044627

DOI: 10.1124/mol.65.4.973

PubMed ID: 15574495

Title: 15-Hydroxyprostaglandin dehydrogenase, a COX-2 oncogene antagonist, is a TGF-beta-induced suppressor of human gastrointestinal cancers.

PubMed ID: 15574495

DOI: 10.1073/pnas.0406142101

PubMed ID: 16828555

Title: Role of glutamine 148 of human 15-hydroxyprostaglandin dehydrogenase in catalytic oxidation of prostaglandin E2.

PubMed ID: 16828555

DOI: 10.1016/j.bmc.2006.06.030

PubMed ID: 16757471

Title: Metabolic inactivation of resolvin E1 and stabilization of its anti-inflammatory actions.

PubMed ID: 16757471

DOI: 10.1074/jbc.m603766200

PubMed ID: 21916491

Title: 11-Oxoeicosatetraenoic acid is a cyclooxygenase-2/15-hydroxyprostaglandin dehydrogenase-derived antiproliferative eicosanoid.

PubMed ID: 21916491

DOI: 10.1021/tx200336f

PubMed ID: 22844113

Title: Resolvin D1 and resolvin D2 govern local inflammatory tone in obese fat.

PubMed ID: 22844113

DOI: 10.4049/jimmunol.1201272

PubMed ID: 25586183

Title: 15-Hydroxyprostaglandin dehydrogenase generation of electrophilic lipid signaling mediators from hydroxy omega-3 fatty acids.

PubMed ID: 25586183

DOI: 10.1074/jbc.m114.635151

PubMed ID: 8482380

Title: Three-dimensional model of NAD(+)-dependent 15-hydroxyprostaglandin dehydrogenase and relationships to the NADP(+)-dependent enzyme (carbonyl reductase).

PubMed ID: 8482380

DOI: 10.1016/0014-5793(93)81554-d

PubMed ID: 18500342

Title: Mutations in 15-hydroxyprostaglandin dehydrogenase cause primary hypertrophic osteoarthropathy.

PubMed ID: 18500342

DOI: 10.1038/ng.153

PubMed ID: 21072165

Title: High-affinity inhibitors of human NAD-dependent 15-hydroxyprostaglandin dehydrogenase: mechanisms of inhibition and structure-activity relationships.

PubMed ID: 21072165

DOI: 10.1371/journal.pone.0013719

PubMed ID: 18805827

Title: Mutation in the HPGD gene encoding NAD+ dependent 15-hydroxyprostaglandin dehydrogenase underlies isolated congenital nail clubbing (ICNC).

PubMed ID: 18805827

DOI: 10.1136/jmg.2008.061234

Sequence Information:

  • Length: 266
  • Mass: 28977
  • Checksum: B860D2DE80E49514
  • Sequence:
    • MHVNGKVALV TGAAQGIGRA FAEALLLKGA KVALVDWNLE AGVQCKAALD EQFEPQKTLF 
IQCDVADQQQ LRDTFRKVVD HFGRLDILVN NAGVNNEKNW EKTLQINLVS VISGTYLGLD 
YMSKQNGGEG GIIINMSSLA GLMPVAQQPV YCASKHGIVG FTRSAALAAN LMNSGVRLNA 
ICPGFVNTAI LESIEKEENM GQYIEYKDHI KDMIKYYGIL DPPLIANGLI TLIEDDALNG 
AIMKITTSKG IHFQDYDTTP FQAKTQ

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.