Details for: HPGD

Gene ID: 3248

Symbol: HPGD

Ensembl ID: ENSG00000164120

Description: 15-hydroxyprostaglandin dehydrogenase

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: alveolar capillary type 2 endothelial cell (CL4028003)
    Fold Change: 4.73
    Marker Score: 6851
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 3.97
    Marker Score: 34874
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 3.2
    Marker Score: 56748
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: 3.04
    Marker Score: 19384
  • Cell Name: basophil (CL0000767)
    Fold Change: 3.03
    Marker Score: 1438
  • Cell Name: alveolar capillary type 1 endothelial cell (CL4028002)
    Fold Change: 2.59
    Marker Score: 6585
  • Cell Name: enterocyte (CL0000584)
    Fold Change: 2.57
    Marker Score: 12322
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 2.51
    Marker Score: 3696
  • Cell Name: taste receptor cell (CL0000209)
    Fold Change: 2.24
    Marker Score: 1931
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: 2.22
    Marker Score: 56762
  • Cell Name: enterocyte of colon (CL1000347)
    Fold Change: 1.99
    Marker Score: 3063
  • Cell Name: colon epithelial cell (CL0011108)
    Fold Change: 1.96
    Marker Score: 6159.5
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: 1.93
    Marker Score: 7146
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: 1.91
    Marker Score: 16425
  • Cell Name: type G enteroendocrine cell (CL0000508)
    Fold Change: 1.88
    Marker Score: 649
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 1.7
    Marker Score: 422
  • Cell Name: epithelial cell of urethra (CL1000296)
    Fold Change: 1.68
    Marker Score: 1322
  • Cell Name: basal cell of epithelium of trachea (CL1000348)
    Fold Change: 1.56
    Marker Score: 11600
  • Cell Name: kidney collecting duct cell (CL1001225)
    Fold Change: 1.39
    Marker Score: 272
  • Cell Name: mucous neck cell (CL0000651)
    Fold Change: 1.3
    Marker Score: 2940
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: 1.24
    Marker Score: 830
  • Cell Name: midzonal region hepatocyte (CL0019028)
    Fold Change: 1.22
    Marker Score: 5284
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: 1.22
    Marker Score: 9524
  • Cell Name: kidney collecting duct principal cell (CL1001431)
    Fold Change: 1.16
    Marker Score: 2921
  • Cell Name: epithelial cell of lung (CL0000082)
    Fold Change: 1.14
    Marker Score: 5986
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 1.13
    Marker Score: 11671
  • Cell Name: granulocyte (CL0000094)
    Fold Change: 1.12
    Marker Score: 501
  • Cell Name: primitive red blood cell (CL0002355)
    Fold Change: 1.1
    Marker Score: 827
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 1.09
    Marker Score: 7026
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: 1.08
    Marker Score: 5786
  • Cell Name: enterocyte of epithelium proper of ileum (CL1000342)
    Fold Change: 1.06
    Marker Score: 305
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: 1.05
    Marker Score: 940
  • Cell Name: intestine goblet cell (CL0019031)
    Fold Change: 1.04
    Marker Score: 999
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: 1.04
    Marker Score: 870
  • Cell Name: intestinal crypt stem cell (CL0002250)
    Fold Change: 1.03
    Marker Score: 387
  • Cell Name: precursor cell (CL0011115)
    Fold Change: 1.02
    Marker Score: 247
  • Cell Name: papillary tips cell (CL1000597)
    Fold Change: 1.01
    Marker Score: 203
  • Cell Name: peptic cell (CL0000155)
    Fold Change: 1
    Marker Score: 418
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71758
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 47983
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30402
  • Cell Name: elicited macrophage (CL0000861)
    Fold Change: 0.97
    Marker Score: 5920
  • Cell Name: podocyte (CL0000653)
    Fold Change: 0.97
    Marker Score: 360
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.96
    Marker Score: 495
  • Cell Name: melanocyte (CL0000148)
    Fold Change: 0.95
    Marker Score: 386
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.95
    Marker Score: 449
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2407
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.93
    Marker Score: 5325
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.93
    Marker Score: 1507
  • Cell Name: type EC enteroendocrine cell (CL0000577)
    Fold Change: 0.91
    Marker Score: 860
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2723
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.91
    Marker Score: 904
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.88
    Marker Score: 317
  • Cell Name: hepatic stellate cell (CL0000632)
    Fold Change: 0.88
    Marker Score: 332
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5265
  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.85
    Marker Score: 493
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 0.84
    Marker Score: 5369
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.84
    Marker Score: 1586
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: 0.83
    Marker Score: 566
  • Cell Name: trophoblast giant cell (CL0002488)
    Fold Change: 0.82
    Marker Score: 267
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.82
    Marker Score: 494
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.82
    Marker Score: 627
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: 0.81
    Marker Score: 2880
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.81
    Marker Score: 1979
  • Cell Name: decidual natural killer cell, human (CL0002343)
    Fold Change: 0.8
    Marker Score: 2199
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.77
    Marker Score: 308
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.74
    Marker Score: 385
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.73
    Marker Score: 464
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.72
    Marker Score: 11221
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.72
    Marker Score: 3003
  • Cell Name: chromaffin cell (CL0000166)
    Fold Change: 0.71
    Marker Score: 1001
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: 0.71
    Marker Score: 1025
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.7
    Marker Score: 640
  • Cell Name: mature gamma-delta T cell (CL0000800)
    Fold Change: 0.69
    Marker Score: 2189
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: 0.69
    Marker Score: 1103
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.68
    Marker Score: 175
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: 0.67
    Marker Score: 711
  • Cell Name: Leydig cell (CL0000178)
    Fold Change: 0.67
    Marker Score: 719
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.66
    Marker Score: 2594
  • Cell Name: mucosal invariant T cell (CL0000940)
    Fold Change: 0.64
    Marker Score: 571
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.64
    Marker Score: 264
  • Cell Name: glandular epithelial cell (CL0000150)
    Fold Change: 0.64
    Marker Score: 1563
  • Cell Name: M cell of gut (CL0000682)
    Fold Change: 0.63
    Marker Score: 164
  • Cell Name: secretory cell (CL0000151)
    Fold Change: 0.63
    Marker Score: 1148
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: 0.62
    Marker Score: 993
  • Cell Name: stem cell (CL0000034)
    Fold Change: 0.6
    Marker Score: 1432
  • Cell Name: kidney connecting tubule epithelial cell (CL1000768)
    Fold Change: 0.59
    Marker Score: 839
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: 0.59
    Marker Score: 298
  • Cell Name: lung macrophage (CL1001603)
    Fold Change: 0.59
    Marker Score: 670.5
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: 0.58
    Marker Score: 618
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.58
    Marker Score: 1360
  • Cell Name: alternatively activated macrophage (CL0000890)
    Fold Change: 0.57
    Marker Score: 238
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.55
    Marker Score: 437
  • Cell Name: ionocyte (CL0005006)
    Fold Change: 0.55
    Marker Score: 166
  • Cell Name: syncytiotrophoblast cell (CL0000525)
    Fold Change: 0.54
    Marker Score: 445
  • Cell Name: Unknown (CL0000548)
    Fold Change: 0.54
    Marker Score: 391
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 0.54
    Marker Score: 154
  • Cell Name: capillary endothelial cell (CL0002144)
    Fold Change: 0.53
    Marker Score: 572
  • Cell Name: hematopoietic precursor cell (CL0008001)
    Fold Change: 0.53
    Marker Score: 184
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: 0.52
    Marker Score: 519

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Other Information

**Key characteristics:** - PGDH is a multi-functional enzyme that can act as an eicosanoid and prostaglandin D2 receptor (PGD2R) antagonist. - It is highly expressed in various cell types, including endothelial cells, macrophages, and immune cells. - PGDH is a regulator of inflammation and inflammation-related diseases. **Pathways and functions:** - PGDH is involved in multiple pathways, including arachidonic acid metabolism, biosynthesis of d-series resolvins, synthesis of e-series 18(s)-resolvins, and biosynthesis of specialized proresolving mediators (spms). - It also plays a role in fatty acid metabolism and is involved in the regulation of inflammation and immune responses. **Clinical significance:** - Mutations in the HPGD gene have been linked to several human diseases, including asthma, rheumatoid arthritis, and inflammatory bowel disease. - PGDH inhibitors are being investigated as potential therapeutic agents for these diseases. - By understanding the role of PGDH in inflammation and immune responses, researchers can develop new strategies to treat inflammatory diseases.

Genular Protein ID: 3871557081

Symbol: PGDH_HUMAN

Name: Eicosanoid/docosanoid dehydrogenase [NAD(+)]

UniProtKB Accession Codes:

P15428 B4DTA4 B4DU74 B4DV57 D3DP43 E7EV11 O00749 Q06F08 Q12998

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 2 Bgee 1 BindingDB 1 BioCyc 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 5 CDD 1 CTD 1 ChEBI 71 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 1 EC 2 EMBL 16 EMDB 3 EPD 1 Ensembl 6 EvolutionaryTrace 1 ExpressionAtlas 1 GO 27 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GuidetoPHARMACOLOGY 1 HGNC 2 HOGENOM 1 HPA 1 InParanoid 1 InterPro 3 KEGG 1 MANE-Select 1 MIM 6 MalaCards 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 3 OrthoDB 1 PANTHER 2 PDB 5 PDBsum 4 PIR 1 PRINTS 2 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 5 Pumba 1 RNAct 1 Reactome 4 RefSeq 6 Rhea 26 SABIO-RK 1 SIGNOR 1 SMR 1 STRING 1 SUPFAM 1 SWISS-2DPAGE 1 SignaLink 1 SwissLipids 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 2337593

Title: Purification and structural characterization of placental NAD(+)-linked 15-hydroxyprostaglandin dehydrogenase. The primary structure reveals the enzyme to belong to the short-chain alcohol dehydrogenase family.

PubMed ID: 2337593

DOI: 10.1021/bi00455a021

PubMed ID: 1697582

Title: Cloning and sequence analysis of the cDNA for human placental NAD(+)-dependent 15-hydroxyprostaglandin dehydrogenase.

PubMed ID: 1697582

DOI: 10.1016/s0021-9258(18)77199-8

PubMed ID: 7557451

Title: Sequence of a novel mRNA coding for a C-terminal-truncated form of human NAD(+)-dependent 15-hydroxyprostaglandin dehydrogenase.

PubMed ID: 7557451

DOI: 10.1016/0378-1119(95)00319-2

PubMed ID: 9099873

Title: Cloning and sequencing of a new 15-hydroxyprostaglandin dehydrogenase related mRNA.

PubMed ID: 9099873

DOI: 10.1016/s0378-1119(96)00800-1

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15815621

Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.

PubMed ID: 15815621

DOI: 10.1038/nature03466

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 2025296

Title: Site-directed mutagenesis of the conserved tyrosine 151 of human placental NAD(+)-dependent 15-hydroxyprostaglandin dehydrogenase yields a catalytically inactive enzyme.

PubMed ID: 2025296

DOI: 10.1016/s0006-291x(05)80262-1

PubMed ID: 8086429

Title: Bacterial expression and site-directed mutagenesis of two critical residues (tyrosine-151 and lysine-155) of human placental NAD(+)-dependent 15-hydroxyprostaglandin dehydrogenase.

PubMed ID: 8086429

DOI: 10.1016/0167-4838(94)90172-4

PubMed ID: 10837478

Title: Oxidoreductases in lipoxin A4 metabolic inactivation: a novel role for 15-onoprostaglandin 13-reductase/leukotriene B4 12-hydroxydehydrogenase in inflammation.

PubMed ID: 10837478

DOI: 10.1074/jbc.m002863200

PubMed ID: 12788907

Title: Mechanism of cortisol/progesterone antagonism in the regulation of 15-hydroxyprostaglandin dehydrogenase activity and messenger ribonucleic acid levels in human chorion and placental trophoblast cells at term.

PubMed ID: 12788907

DOI: 10.1210/jc.2002-021710

PubMed ID: 15044627

Title: The two-step model of prostaglandin signal termination: in vitro reconstitution with the prostaglandin transporter and prostaglandin 15 dehydrogenase.

PubMed ID: 15044627

DOI: 10.1124/mol.65.4.973

PubMed ID: 15574495

Title: 15-Hydroxyprostaglandin dehydrogenase, a COX-2 oncogene antagonist, is a TGF-beta-induced suppressor of human gastrointestinal cancers.

PubMed ID: 15574495

DOI: 10.1073/pnas.0406142101

PubMed ID: 16828555

Title: Role of glutamine 148 of human 15-hydroxyprostaglandin dehydrogenase in catalytic oxidation of prostaglandin E2.

PubMed ID: 16828555

DOI: 10.1016/j.bmc.2006.06.030

PubMed ID: 16757471

Title: Metabolic inactivation of resolvin E1 and stabilization of its anti-inflammatory actions.

PubMed ID: 16757471

DOI: 10.1074/jbc.m603766200

PubMed ID: 21916491

Title: 11-Oxoeicosatetraenoic acid is a cyclooxygenase-2/15-hydroxyprostaglandin dehydrogenase-derived antiproliferative eicosanoid.

PubMed ID: 21916491

DOI: 10.1021/tx200336f

PubMed ID: 22844113

Title: Resolvin D1 and resolvin D2 govern local inflammatory tone in obese fat.

PubMed ID: 22844113

DOI: 10.4049/jimmunol.1201272

PubMed ID: 25586183

Title: 15-Hydroxyprostaglandin dehydrogenase generation of electrophilic lipid signaling mediators from hydroxy omega-3 fatty acids.

PubMed ID: 25586183

DOI: 10.1074/jbc.m114.635151

PubMed ID: 8482380

Title: Three-dimensional model of NAD(+)-dependent 15-hydroxyprostaglandin dehydrogenase and relationships to the NADP(+)-dependent enzyme (carbonyl reductase).

PubMed ID: 8482380

DOI: 10.1016/0014-5793(93)81554-d

PubMed ID: 18500342

Title: Mutations in 15-hydroxyprostaglandin dehydrogenase cause primary hypertrophic osteoarthropathy.

PubMed ID: 18500342

DOI: 10.1038/ng.153

PubMed ID: 21072165

Title: High-affinity inhibitors of human NAD-dependent 15-hydroxyprostaglandin dehydrogenase: mechanisms of inhibition and structure-activity relationships.

PubMed ID: 21072165

DOI: 10.1371/journal.pone.0013719

PubMed ID: 18805827

Title: Mutation in the HPGD gene encoding NAD+ dependent 15-hydroxyprostaglandin dehydrogenase underlies isolated congenital nail clubbing (ICNC).

PubMed ID: 18805827

DOI: 10.1136/jmg.2008.061234

Sequence Information:

  • Length: 266
  • Mass: 28977
  • Checksum: B860D2DE80E49514
  • Sequence:
    • MHVNGKVALV TGAAQGIGRA FAEALLLKGA KVALVDWNLE AGVQCKAALD EQFEPQKTLF 
IQCDVADQQQ LRDTFRKVVD HFGRLDILVN NAGVNNEKNW EKTLQINLVS VISGTYLGLD 
YMSKQNGGEG GIIINMSSLA GLMPVAQQPV YCASKHGIVG FTRSAALAAN LMNSGVRLNA 
ICPGFVNTAI LESIEKEENM GQYIEYKDHI KDMIKYYGIL DPPLIANGLI TLIEDDALNG 
AIMKITTSKG IHFQDYDTTP FQAKTQ

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.