Details for: THY1

Gene ID: 7070

Symbol: THY1

Ensembl ID: ENSG00000154096

Description: Thy-1 cell surface antigen

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 170.0813
    Cell Significance Index: -43.1400
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 100.8866
    Cell Significance Index: -41.5600
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 88.2077
    Cell Significance Index: -35.8400
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 87.6044
    Cell Significance Index: -41.3600
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 34.8999
    Cell Significance Index: -43.0300
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 10.8944
    Cell Significance Index: -42.9900
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 4.0490
    Cell Significance Index: 212.5900
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: 2.6401
    Cell Significance Index: 75.3400
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 2.1880
    Cell Significance Index: 438.9200
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 1.7403
    Cell Significance Index: 117.0200
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 1.1388
    Cell Significance Index: 408.4900
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 0.9213
    Cell Significance Index: 40.7500
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 0.8675
    Cell Significance Index: 32.8500
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 0.8447
    Cell Significance Index: 17.6800
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.4891
    Cell Significance Index: 30.0600
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: 0.3664
    Cell Significance Index: 3.0300
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.3168
    Cell Significance Index: 43.5000
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 0.3007
    Cell Significance Index: 8.6200
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.2710
    Cell Significance Index: 187.4100
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: 0.2418
    Cell Significance Index: 4.7200
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 0.1480
    Cell Significance Index: 2.2900
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.1356
    Cell Significance Index: 99.4300
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.0738
    Cell Significance Index: 1.2400
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 0.0652
    Cell Significance Index: 0.8400
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0244
    Cell Significance Index: 46.0000
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.0046
    Cell Significance Index: -0.1100
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0135
    Cell Significance Index: -20.7300
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0153
    Cell Significance Index: -28.2200
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0205
    Cell Significance Index: -27.9300
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0256
    Cell Significance Index: -18.9800
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0380
    Cell Significance Index: -23.7300
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0396
    Cell Significance Index: -22.3200
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0566
    Cell Significance Index: -42.8100
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0590
    Cell Significance Index: -37.4900
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: -0.0622
    Cell Significance Index: -27.5000
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0762
    Cell Significance Index: -41.6200
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0924
    Cell Significance Index: -41.9300
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: -0.1024
    Cell Significance Index: -0.8500
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.1120
    Cell Significance Index: -12.7800
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1131
    Cell Significance Index: -23.8200
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.1209
    Cell Significance Index: -15.5000
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.1263
    Cell Significance Index: -36.3500
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.1367
    Cell Significance Index: -27.1200
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.1680
    Cell Significance Index: -28.6900
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.1889
    Cell Significance Index: -34.0600
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.1976
    Cell Significance Index: -28.7200
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: -0.2345
    Cell Significance Index: -1.9700
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.2823
    Cell Significance Index: -28.8400
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.2898
    Cell Significance Index: -35.6400
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.2984
    Cell Significance Index: -38.5500
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: -0.3104
    Cell Significance Index: -3.8500
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.3201
    Cell Significance Index: -7.0100
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.3538
    Cell Significance Index: -7.5100
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.3538
    Cell Significance Index: -41.2300
  • Cell Name: hippocampal interneuron (CL1001569)
    Fold Change: -0.3624
    Cell Significance Index: -4.7000
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.3874
    Cell Significance Index: -30.6800
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.3891
    Cell Significance Index: -44.5800
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.4063
    Cell Significance Index: -42.3100
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.4804
    Cell Significance Index: -13.4300
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.5031
    Cell Significance Index: -23.6500
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.5205
    Cell Significance Index: -38.7900
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.5256
    Cell Significance Index: -13.5100
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.5460
    Cell Significance Index: -17.3900
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.5759
    Cell Significance Index: -44.2000
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.6074
    Cell Significance Index: -12.0100
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.6075
    Cell Significance Index: -39.1900
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.6307
    Cell Significance Index: -20.6500
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.6339
    Cell Significance Index: -33.0200
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -0.6344
    Cell Significance Index: -13.5600
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.6541
    Cell Significance Index: -11.2100
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.6596
    Cell Significance Index: -14.2500
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.6812
    Cell Significance Index: -13.6800
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.6991
    Cell Significance Index: -44.0600
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.7652
    Cell Significance Index: -42.9400
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.8195
    Cell Significance Index: -28.7100
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.8347
    Cell Significance Index: -20.8200
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.8581
    Cell Significance Index: -44.5800
  • Cell Name: OFF midget ganglion cell (CL4033047)
    Fold Change: -0.9158
    Cell Significance Index: -11.4200
  • Cell Name: melanocyte of skin (CL1000458)
    Fold Change: -0.9418
    Cell Significance Index: -13.2000
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.9750
    Cell Significance Index: -45.4600
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -1.0352
    Cell Significance Index: -21.6100
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -1.0435
    Cell Significance Index: -36.2600
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -1.0464
    Cell Significance Index: -30.8200
  • Cell Name: inflammatory cell (CL0009002)
    Fold Change: -1.0464
    Cell Significance Index: -6.0000
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -1.0915
    Cell Significance Index: -12.4000
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -1.1180
    Cell Significance Index: -41.0400
  • Cell Name: keratocyte (CL0002363)
    Fold Change: -1.1440
    Cell Significance Index: -18.1500
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: -1.2604
    Cell Significance Index: -31.4300
  • Cell Name: cerebral cortex neuron (CL0010012)
    Fold Change: -1.3022
    Cell Significance Index: -12.3900
  • Cell Name: neuron (CL0000540)
    Fold Change: -1.3250
    Cell Significance Index: -12.5600
  • Cell Name: ON midget ganglion cell (CL4033046)
    Fold Change: -1.3461
    Cell Significance Index: -16.9900
  • Cell Name: peg cell (CL4033014)
    Fold Change: -1.3487
    Cell Significance Index: -31.1600
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -1.3630
    Cell Significance Index: -14.8500
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: -1.4010
    Cell Significance Index: -27.5800
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -1.4147
    Cell Significance Index: -20.2600
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -1.4323
    Cell Significance Index: -42.0700
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -1.4722
    Cell Significance Index: -39.3800
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: -1.4743
    Cell Significance Index: -46.6300
  • Cell Name: neural cell (CL0002319)
    Fold Change: -1.5018
    Cell Significance Index: -17.5200
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -1.5362
    Cell Significance Index: -41.0200

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** The THY1 gene is a transmembrane glycoprotein, consisting of an extracellular domain, a transmembrane domain, and an intracellular domain. The extracellular domain contains a glycosylphosphatidylinositol (GPI) anchor, which mediates protein attachment to the plasma membrane. The transmembrane domain spans the plasma membrane, while the intracellular domain interacts with various signaling molecules and cytoskeletal proteins. The THY1 protein is highly glycosylated, with multiple glycosylation sites, which contribute to its stability and function. **Pathways and Functions** The THY1 protein is involved in various signaling pathways, including: 1. **Cell-cell adhesion**: THY1 mediates cell-cell adhesion through its interaction with other cell surface proteins, such as integrins and cadherins. 2. **Cell migration**: THY1 regulates cell migration by interacting with cytoskeletal proteins, such as actin and myosin, and modulating the activity of signaling molecules, such as GTPases. 3. **Signaling pathways**: THY1 interacts with various signaling molecules, including GTPases, protein kinases, and phosphatases, to regulate cellular responses to stimuli. 4. **Cytoskeleton organization**: THY1 regulates cytoskeleton organization by interacting with cytoskeletal proteins, such as actin and myosin, and modulating the activity of signaling molecules. **Clinical Significance** Dysregulation of the THY1 gene has been implicated in various diseases, including: 1. **Cancer**: THY1 overexpression has been observed in various types of cancer, including breast, lung, and colon cancer, and has been associated with poor prognosis. 2. **Autoimmune disorders**: THY1 has been implicated in autoimmune disorders, such as multiple sclerosis and rheumatoid arthritis, where it regulates immune cell function and tissue damage. 3. **Neurological disorders**: THY1 has been implicated in neurological disorders, such as Alzheimer's disease and Parkinson's disease, where it regulates neuronal function and survival. In summary, the THY1 gene encodes for a transmembrane glycoprotein that plays a crucial role in various cellular processes, including cell-cell adhesion, migration, and signaling. Its dysregulation has been implicated in various diseases, including cancer, autoimmune disorders, and neurological disorders. Further research is needed to fully understand the mechanisms by which THY1 regulates cellular function and to develop therapeutic strategies to target its dysregulation in disease.

Genular Protein ID: 213544204

Symbol: THY1_HUMAN

Name: Thy-1 membrane glycoprotein

UniProtKB Accession Codes:

P04216 Q16008 Q9NSP1

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CPTAC 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 5 Ensembl 2 ExpressionAtlas 1 GO 39 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyConnect 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 6 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 2 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 1 RefSeq 3 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 2864690

Title: The human Thy-1 gene: structure and chromosomal location.

PubMed ID: 2864690

DOI: 10.1073/pnas.82.19.6657

PubMed ID: 10944468

Title: cDNA cloning by amplification of circularized first strand cDNAs reveals non-IRE-regulated iron-responsive mRNAs.

PubMed ID: 10944468

DOI: 10.1006/bbrc.2000.3282

PubMed ID: 17974005

Title: The full-ORF clone resource of the German cDNA consortium.

PubMed ID: 17974005

DOI: 10.1186/1471-2164-8-399

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 7683034

Title: Expression of Thy-1 on human hematopoietic progenitor cells.

PubMed ID: 7683034

DOI: 10.1084/jem.177.5.1331

PubMed ID: 19159218

Title: Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry.

PubMed ID: 19159218

DOI: 10.1021/pr8008012

PubMed ID: 19349973

Title: Mass-spectrometric identification and relative quantification of N-linked cell surface glycoproteins.

PubMed ID: 19349973

DOI: 10.1038/nbt.1532

Sequence Information:

  • Length: 161
  • Mass: 17935
  • Checksum: 2B6796DA8EE7454B
  • Sequence:
    • MNLAISIALL LTVLQVSRGQ KVTSLTACLV DQSLRLDCRH ENTSSSPIQY EFSLTRETKK 
HVLFGTVGVP EHTYRSRTNF TSKYNMKVLY LSAFTSKDEG TYTCALHHSG HSPPISSQNV 
TVLRDKLVKC EGISLLAQNT SWLLLLLLSL SLLQATDFMS L

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.