Details for: LGALS3BP

Gene ID: 3959

Symbol: LGALS3BP

Ensembl ID: ENSG00000108679

Description: galectin 3 binding protein

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 289.2406
    Cell Significance Index: -44.9900
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 162.0780
    Cell Significance Index: -41.1100
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 111.6161
    Cell Significance Index: -45.9800
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 97.9675
    Cell Significance Index: -39.8000
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 96.5427
    Cell Significance Index: -45.5800
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 87.0554
    Cell Significance Index: -44.7800
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 68.6788
    Cell Significance Index: -46.0900
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 41.8123
    Cell Significance Index: -39.9200
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 37.0167
    Cell Significance Index: -45.6400
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 16.6937
    Cell Significance Index: -44.7200
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 11.4773
    Cell Significance Index: -45.2900
  • Cell Name: theca cell (CL0000503)
    Fold Change: 9.1710
    Cell Significance Index: 53.8800
  • Cell Name: peg cell (CL4033014)
    Fold Change: 4.8642
    Cell Significance Index: 112.3800
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 4.1190
    Cell Significance Index: 108.3100
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: 4.0620
    Cell Significance Index: 34.1200
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 4.0212
    Cell Significance Index: 437.3800
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 3.4070
    Cell Significance Index: 158.8500
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 3.3753
    Cell Significance Index: 432.7000
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 3.3433
    Cell Significance Index: 30.7900
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 3.3228
    Cell Significance Index: 90.4500
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 3.3059
    Cell Significance Index: 453.9900
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 2.4823
    Cell Significance Index: 128.9500
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: 2.4608
    Cell Significance Index: 15.2900
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 2.3289
    Cell Significance Index: 29.8300
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 2.1503
    Cell Significance Index: 32.2200
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 2.0615
    Cell Significance Index: 203.9300
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 2.0442
    Cell Significance Index: 1116.3800
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 1.9016
    Cell Significance Index: 50.9600
  • Cell Name: salivary gland glandular cell (CL1001596)
    Fold Change: 1.7750
    Cell Significance Index: 9.8800
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 1.5071
    Cell Significance Index: 68.3100
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 1.4930
    Cell Significance Index: 269.1400
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 1.4145
    Cell Significance Index: 105.4200
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 1.3910
    Cell Significance Index: 171.0400
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 1.3087
    Cell Significance Index: 37.7100
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 1.0614
    Cell Significance Index: 137.1300
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.8558
    Cell Significance Index: 59.1800
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.8253
    Cell Significance Index: 163.7800
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 0.8104
    Cell Significance Index: 23.2300
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.5792
    Cell Significance Index: 27.2200
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.5391
    Cell Significance Index: 38.1300
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.4843
    Cell Significance Index: 78.7700
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: 0.4678
    Cell Significance Index: 9.1300
  • Cell Name: seromucus secreting cell (CL0000159)
    Fold Change: 0.4565
    Cell Significance Index: 9.5200
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.3861
    Cell Significance Index: 170.7000
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.3847
    Cell Significance Index: 10.7500
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.3822
    Cell Significance Index: 8.1400
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.3389
    Cell Significance Index: 64.5000
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: 0.3059
    Cell Significance Index: 4.2900
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.2891
    Cell Significance Index: 9.2600
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.1819
    Cell Significance Index: 6.3900
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.1633
    Cell Significance Index: 123.6200
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.0993
    Cell Significance Index: 89.6300
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.0552
    Cell Significance Index: 40.4700
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.0391
    Cell Significance Index: 6.6800
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.0363
    Cell Significance Index: 0.9700
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.0096
    Cell Significance Index: 0.1600
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.0029
    Cell Significance Index: 0.3000
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0067
    Cell Significance Index: -12.7000
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0108
    Cell Significance Index: -7.9800
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0204
    Cell Significance Index: -7.3300
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0224
    Cell Significance Index: -41.3900
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0255
    Cell Significance Index: -39.2400
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0346
    Cell Significance Index: -21.5800
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0364
    Cell Significance Index: -49.5200
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0464
    Cell Significance Index: -26.1900
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0504
    Cell Significance Index: -32.0200
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0739
    Cell Significance Index: -21.2700
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0762
    Cell Significance Index: -16.0500
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0840
    Cell Significance Index: -9.6200
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0947
    Cell Significance Index: -42.9900
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.1120
    Cell Significance Index: -7.2300
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.1230
    Cell Significance Index: -14.3300
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.1486
    Cell Significance Index: -3.2200
  • Cell Name: ovarian surface epithelial cell (CL2000064)
    Fold Change: -0.1665
    Cell Significance Index: -0.8100
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.1758
    Cell Significance Index: -4.4900
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.1979
    Cell Significance Index: -2.7000
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.2120
    Cell Significance Index: -24.2000
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.2138
    Cell Significance Index: -42.9000
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.2309
    Cell Significance Index: -12.1300
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.2462
    Cell Significance Index: -12.4400
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.2633
    Cell Significance Index: -38.2800
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.3285
    Cell Significance Index: -25.2100
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.3308
    Cell Significance Index: -8.2700
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.3694
    Cell Significance Index: -43.5600
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.3763
    Cell Significance Index: -15.4200
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.3951
    Cell Significance Index: -4.0900
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.3994
    Cell Significance Index: -11.7300
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.4373
    Cell Significance Index: -45.5300
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.5102
    Cell Significance Index: -17.7300
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.5107
    Cell Significance Index: -28.6600
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.5157
    Cell Significance Index: -40.8400
  • Cell Name: oral mucosa squamous cell (CL1001576)
    Fold Change: -0.5667
    Cell Significance Index: -4.8700
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: -0.5874
    Cell Significance Index: -3.9800
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.6148
    Cell Significance Index: -41.3400
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.6478
    Cell Significance Index: -40.8300
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.6694
    Cell Significance Index: -34.8700
  • Cell Name: stem cell (CL0000034)
    Fold Change: -0.6962
    Cell Significance Index: -5.0600
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.7395
    Cell Significance Index: -45.4600
  • Cell Name: enterocyte (CL0000584)
    Fold Change: -0.7431
    Cell Significance Index: -4.6100
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.7443
    Cell Significance Index: -45.6300

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** LGALS3BP is a member of the galectin family, characterized by its ability to bind to galectin-3, a lectin that plays a crucial role in cell-cell interactions and immune response. This protein is composed of three domains: a galectin-3 binding domain, a carbohydrate-binding domain, and a C-terminal domain that mediates protein-protein interactions. LGALS3BP is secreted by various cell types and can interact with galectin-3, influencing its activity and function. **Pathways and Functions:** LGALS3BP is involved in several key biological pathways, including: 1. **Cell adhesion:** LGALS3BP promotes cell adhesion by interacting with galectin-3, which in turn modulates the expression of adhesion molecules, such as integrins and selectins. 2. **Immune response:** LGALS3BP regulates immune response by modulating the activity of galectin-3, which plays a crucial role in the regulation of immune cell function, including T-cell activation and proliferation. 3. **Extracellular matrix regulation:** LGALS3BP modulates the structure and function of the extracellular matrix by regulating the expression of matrix metalloproteinases and other matrix-degrading enzymes. 4. **Signaling and aggregation:** LGALS3BP interacts with galectin-3, which in turn modulates signaling pathways, including the PI3K/Akt pathway, and promotes platelet aggregation and activation. **Clinical Significance:** LGALS3BP has been implicated in various disease states, including: 1. **Cancer:** LGALS3BP is overexpressed in several types of cancer, including breast, lung, and colon cancer, and has been associated with poor prognosis and metastasis. 2. **Cardiovascular diseases:** LGALS3BP is involved in the regulation of platelet function and has been implicated in the pathogenesis of cardiovascular diseases, including thrombosis and atherosclerosis. 3. **Autoimmune disorders:** LGALS3BP has been implicated in the regulation of immune responses and has been associated with autoimmune disorders, including rheumatoid arthritis and lupus. 4. **Infectious diseases:** LGALS3BP has been shown to play a role in the regulation of immune responses to infections, including bacterial and viral infections. In conclusion, LGALS3BP is a multifunctional protein that plays a critical role in various biological processes, including cell adhesion, immune response, and extracellular matrix regulation. Its involvement in disease pathogenesis highlights the importance of this protein in understanding the mechanisms of various diseases and developing novel therapeutic strategies.

Genular Protein ID: 1427534528

Symbol: LG3BP_HUMAN

Name: Galectin-3-binding protein

UniProtKB Accession Codes:

Q08380 A0A0S2Z3Y1 Q7M4S0 Q9UCH8 Q9UCH9 Q9UCI0

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 2 CPTAC 5 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 7 Ensembl 1 EvolutionaryTrace 1 ExpressionAtlas 1 GO 11 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyConnect 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 7 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 2 PDBsum 2 PIR 2 PRIDE 1 PRINTS 1 PRO 1 PROSITE 3 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 1 RefSeq 1 SIGNOR 1 SMART 2 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8390986

Title: Cloning and characterization of a human Mac-2-binding protein, a new member of the superfamily defined by the macrophage scavenger receptor cysteine-rich domain.

PubMed ID: 8390986

DOI: 10.1016/s0021-9258(19)85233-x

PubMed ID: 8034587

Title: The secreted tumor-associated antigen 90K is a potent immune stimulator.

PubMed ID: 8034587

DOI: 10.1016/s0021-9258(17)32322-0

PubMed ID: 26871637

Title: Widespread Expansion of Protein Interaction Capabilities by Alternative Splicing.

PubMed ID: 26871637

DOI: 10.1016/j.cell.2016.01.029

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8454062

Title: Purification and characterization of a 90 kDa protein released from human tumors and tumor cell lines.

PubMed ID: 8454062

DOI: 10.1016/0014-5793(93)80037-u

PubMed ID: 8757764

Title: The 105-kDa basement membrane autoantigen p105 is N-terminally homologous to a tumor-associated antigen.

PubMed ID: 8757764

DOI: 10.1111/1523-1747.ep12329629

PubMed ID: 11867635

Title: Functional studies on recombinant domains of Mac-2-binding protein.

PubMed ID: 11867635

DOI: 10.1074/jbc.m200386200

PubMed ID: 11146440

Title: Glycoprotein 90K/MAC-2BP interacts with galectin-1 and mediates galectin-1-induced cell aggregation.

PubMed ID: 11146440

DOI: 10.1002/1097-0215(200002)9999:9999<::aid-ijc1022>3.3.co;2-q

PubMed ID: 15084671

Title: A proteomic analysis of human bile.

PubMed ID: 15084671

DOI: 10.1074/mcp.m400015-mcp200

PubMed ID: 16335952

Title: Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry.

PubMed ID: 16335952

DOI: 10.1021/pr0502065

PubMed ID: 16740002

Title: Identification of N-linked glycoproteins in human saliva by glycoprotein capture and mass spectrometry.

PubMed ID: 16740002

DOI: 10.1021/pr050492k

PubMed ID: 18780401

Title: Identification of N-linked glycoproteins in human milk by hydrophilic interaction liquid chromatography and mass spectrometry.

PubMed ID: 18780401

DOI: 10.1002/pmic.200701057

PubMed ID: 19159218

Title: Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry.

PubMed ID: 19159218

DOI: 10.1021/pr8008012

PubMed ID: 19139490

Title: A strategy for precise and large scale identification of core fucosylated glycoproteins.

PubMed ID: 19139490

DOI: 10.1074/mcp.m800504-mcp200

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 29162697

Title: EB1-binding-myomegalin protein complex promotes centrosomal microtubules functions.

PubMed ID: 29162697

DOI: 10.1073/pnas.1705682114

PubMed ID: 9501082

Title: Mac-2 binding protein is a cell-adhesive protein of the extracellular matrix which self-assembles into ring-like structures and binds beta1 integrins, collagens and fibronectin.

PubMed ID: 9501082

DOI: 10.1093/emboj/17.6.1606

Sequence Information:

  • Length: 585
  • Mass: 65331
  • Checksum: C488C2E99D77435B
  • Sequence:
    • MTPPRLFWVW LLVAGTQGVN DGDMRLADGG ATNQGRVEIF YRGQWGTVCD NLWDLTDASV 
VCRALGFENA TQALGRAAFG QGSGPIMLDE VQCTGTEASL ADCKSLGWLK SNCRHERDAG 
VVCTNETRST HTLDLSRELS EALGQIFDSQ RGCDLSISVN VQGEDALGFC GHTVILTANL 
EAQALWKEPG SNVTMSVDAE CVPMVRDLLR YFYSRRIDIT LSSVKCFHKL ASAYGARQLQ 
GYCASLFAIL LPQDPSFQMP LDLYAYAVAT GDALLEKLCL QFLAWNFEAL TQAEAWPSVP 
TDLLQLLLPR SDLAVPSELA LLKAVDTWSW GERASHEEVE GLVEKIRFPM MLPEELFELQ 
FNLSLYWSHE ALFQKKTLQA LEFHTVPFQL LARYKGLNLT EDTYKPRIYT SPTWSAFVTD 
SSWSARKSQL VYQSRRGPLV KYSSDYFQAP SDYRYYPYQS FQTPQHPSFL FQDKRVSWSL 
VYLPTIQSCW NYGFSCSSDE LPVLGLTKSG GSDRTIAYEN KALMLCEGLF VADVTDFEGW 
KAAIPSALDT NSSKSTSSFP CPAGHFNGFR TVIRPFYLTN SSGVD

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.