Details for: LGALS3BP

Gene ID: 3959

Symbol: LGALS3BP

Ensembl ID: ENSG00000108679

Description: galectin 3 binding protein

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: 3.06
    Marker Score: 19551
  • Cell Name: enterocyte (CL0000584)
    Fold Change: 3.04
    Marker Score: 14581
  • Cell Name: mucous neck cell (CL0000651)
    Fold Change: 2.87
    Marker Score: 6515
  • Cell Name: fibroblast of connective tissue of nonglandular part of prostate (CL1000304)
    Fold Change: 2.86
    Marker Score: 2440
  • Cell Name: epithelial cell of lung (CL0000082)
    Fold Change: 2.86
    Marker Score: 15041
  • Cell Name: type I pneumocyte (CL0002062)
    Fold Change: 2.84
    Marker Score: 3425
  • Cell Name: fibroblast of lung (CL0002553)
    Fold Change: 2.8
    Marker Score: 7322
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 2.76
    Marker Score: 11902.5
  • Cell Name: bronchus fibroblast of lung (CL2000093)
    Fold Change: 2.74
    Marker Score: 3769
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: 2.64
    Marker Score: 4203
  • Cell Name: colon epithelial cell (CL0011108)
    Fold Change: 2.63
    Marker Score: 8265
  • Cell Name: kidney collecting duct principal cell (CL1001431)
    Fold Change: 2.62
    Marker Score: 6604.5
  • Cell Name: enterocyte of colon (CL1000347)
    Fold Change: 2.54
    Marker Score: 3908
  • Cell Name: basal cell of epithelium of trachea (CL1000348)
    Fold Change: 2.53
    Marker Score: 18844
  • Cell Name: theca cell (CL0000503)
    Fold Change: 2.49
    Marker Score: 1786.5
  • Cell Name: P/D1 enteroendocrine cell (CL0002268)
    Fold Change: 2.49
    Marker Score: 928
  • Cell Name: type G enteroendocrine cell (CL0000508)
    Fold Change: 2.46
    Marker Score: 848
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 2.4
    Marker Score: 83085
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: 2.36
    Marker Score: 6331.5
  • Cell Name: fibroblast of connective tissue of glandular part of prostate (CL1000305)
    Fold Change: 2.33
    Marker Score: 970
  • Cell Name: intestine goblet cell (CL0019031)
    Fold Change: 2.33
    Marker Score: 2233
  • Cell Name: pneumocyte (CL0000322)
    Fold Change: 2.31
    Marker Score: 3708
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 2.31
    Marker Score: 25967
  • Cell Name: lung secretory cell (CL1000272)
    Fold Change: 2.26
    Marker Score: 2020
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: 2.26
    Marker Score: 1057
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: 2.24
    Marker Score: 57437
  • Cell Name: ovarian surface epithelial cell (CL2000064)
    Fold Change: 2.23
    Marker Score: 6074
  • Cell Name: secretory cell (CL0000151)
    Fold Change: 2.22
    Marker Score: 4056
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 2.18
    Marker Score: 3208.5
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: 2.17
    Marker Score: 3559.5
  • Cell Name: respiratory goblet cell (CL0002370)
    Fold Change: 2.15
    Marker Score: 622
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 2.13
    Marker Score: 13854
  • Cell Name: type II pneumocyte (CL0002063)
    Fold Change: 2.12
    Marker Score: 13798
  • Cell Name: stem cell (CL0000034)
    Fold Change: 2.11
    Marker Score: 5014.5
  • Cell Name: peptic cell (CL0000155)
    Fold Change: 2.09
    Marker Score: 873
  • Cell Name: serous secreting cell (CL0000313)
    Fold Change: 2.06
    Marker Score: 824
  • Cell Name: kidney connecting tubule epithelial cell (CL1000768)
    Fold Change: 2.05
    Marker Score: 2907
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 1.98
    Marker Score: 4509
  • Cell Name: kidney collecting duct intercalated cell (CL1001432)
    Fold Change: 1.98
    Marker Score: 3280
  • Cell Name: acinar cell (CL0000622)
    Fold Change: 1.97
    Marker Score: 1391
  • Cell Name: type A enteroendocrine cell (CL0002067)
    Fold Change: 1.97
    Marker Score: 793
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 1.97
    Marker Score: 4801
  • Cell Name: club cell (CL0000158)
    Fold Change: 1.96
    Marker Score: 2283
  • Cell Name: tracheobronchial goblet cell (CL0019003)
    Fold Change: 1.93
    Marker Score: 528.5
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 1.92
    Marker Score: 19336
  • Cell Name: glandular cell of esophagus (CL0002657)
    Fold Change: 1.92
    Marker Score: 608
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: 1.92
    Marker Score: 16531
  • Cell Name: fibroblast of connective tissue of prostate (CL1000299)
    Fold Change: 1.91
    Marker Score: 476
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: 1.91
    Marker Score: 1276
  • Cell Name: prostate stromal cell (CL0002622)
    Fold Change: 1.9
    Marker Score: 476
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 1.88
    Marker Score: 7394
  • Cell Name: mesothelial cell of epicardium (CL0011019)
    Fold Change: 1.87
    Marker Score: 601
  • Cell Name: intestinal crypt stem cell (CL0002250)
    Fold Change: 1.86
    Marker Score: 700
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: 1.85
    Marker Score: 10979.5
  • Cell Name: preosteoblast (CL0007010)
    Fold Change: 1.83
    Marker Score: 518
  • Cell Name: Unknown (CL0002371)
    Fold Change: 1.83
    Marker Score: 1940
  • Cell Name: Leydig cell (CL0000178)
    Fold Change: 1.82
    Marker Score: 1962
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 1.81
    Marker Score: 1885
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 1.79
    Marker Score: 6901
  • Cell Name: epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 1.78
    Marker Score: 798
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 1.77
    Marker Score: 1791
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: 1.75
    Marker Score: 7176.5
  • Cell Name: bronchial goblet cell (CL1000312)
    Fold Change: 1.71
    Marker Score: 846
  • Cell Name: basal cell (CL0000646)
    Fold Change: 1.71
    Marker Score: 2202
  • Cell Name: enteroendocrine cell (CL0000164)
    Fold Change: 1.69
    Marker Score: 875
  • Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
    Fold Change: 1.66
    Marker Score: 14442
  • Cell Name: pancreatic stellate cell (CL0002410)
    Fold Change: 1.66
    Marker Score: 1047
  • Cell Name: supporting cell (CL0000630)
    Fold Change: 1.64
    Marker Score: 3082
  • Cell Name: respiratory epithelial cell (CL0002368)
    Fold Change: 1.64
    Marker Score: 903
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: 1.61
    Marker Score: 12587
  • Cell Name: fibroblast (CL0000057)
    Fold Change: 1.59
    Marker Score: 1539
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 1.56
    Marker Score: 360
  • Cell Name: mucus secreting cell (CL0000319)
    Fold Change: 1.56
    Marker Score: 398
  • Cell Name: lung ciliated cell (CL1000271)
    Fold Change: 1.56
    Marker Score: 741
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: 1.55
    Marker Score: 5750
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 1.55
    Marker Score: 52589
  • Cell Name: paneth cell (CL0000510)
    Fold Change: 1.54
    Marker Score: 1074
  • Cell Name: PP cell (CL0000696)
    Fold Change: 1.54
    Marker Score: 346
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: 1.53
    Marker Score: 787
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 1.53
    Marker Score: 1607
  • Cell Name: epithelial cell of lower respiratory tract (CL0002632)
    Fold Change: 1.5
    Marker Score: 6259
  • Cell Name: enterocyte of epithelium proper of ileum (CL1000342)
    Fold Change: 1.5
    Marker Score: 433
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: 1.5
    Marker Score: 1588
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 1.49
    Marker Score: 23940
  • Cell Name: stromal cell of lamina propria of small intestine (CL0009022)
    Fold Change: 1.48
    Marker Score: 333
  • Cell Name: CD1c-positive myeloid dendritic cell (CL0002399)
    Fold Change: 1.48
    Marker Score: 3834
  • Cell Name: multi-ciliated epithelial cell (CL0005012)
    Fold Change: 1.47
    Marker Score: 2794.5
  • Cell Name: kidney interstitial cell (CL1000500)
    Fold Change: 1.47
    Marker Score: 1043
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: 1.46
    Marker Score: 963
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 1.45
    Marker Score: 2944
  • Cell Name: mural cell (CL0008034)
    Fold Change: 1.45
    Marker Score: 165989
  • Cell Name: epithelial cell of urethra (CL1000296)
    Fold Change: 1.44
    Marker Score: 1133
  • Cell Name: pulmonary ionocyte (CL0017000)
    Fold Change: 1.42
    Marker Score: 874
  • Cell Name: fibroblast of breast (CL4006000)
    Fold Change: 1.42
    Marker Score: 812
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 1.41
    Marker Score: 350
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: 1.41
    Marker Score: 820
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 1.41
    Marker Score: 1401.5
  • Cell Name: myofibroblast cell (CL0000186)
    Fold Change: 1.4
    Marker Score: 1729
  • Cell Name: adventitial cell (CL0002503)
    Fold Change: 1.39
    Marker Score: 343
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 1.38
    Marker Score: 2622

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Other Information

**Key characteristics:** * It is a type I transmembrane protein with a molecular weight of approximately 120 kDa. * It is expressed on various cell types, including epithelial cells, fibroblasts, and immune cells. * It is a highly conserved protein with a similar structure and function in mammals. **Pathways and functions:** * LGALS3BP is involved in cell adhesion by binding to galectin receptors on neighboring cells. * It plays a crucial role in cell signaling pathways, interacting with various intracellular signaling molecules. * It is involved in the regulation of cell migration, invasion, and metastasis. * It is also involved in extracellular matrix remodeling, cell migration, and angiogenesis. **Clinical significance:** * Mutations in LGALS3BP have been linked to several human diseases, including cancer, cardiovascular disease, and inflammation. * Overexpression of LGALS3BP is associated with various cancers, including breast cancer, lung cancer, and colon cancer. * Inhibition of LGALS3BP signaling has shown to inhibit tumor growth and metastasis in preclinical models. **Additional information:** * LGALS3BP is a highly versatile protein that can interact with various cellular proteins and molecules. * It is a well-established target for cancer immunotherapy. * Further research is needed to fully understand the role of LGALS3BP in human health and disease.

Genular Protein ID: 1427534528

Symbol: LG3BP_HUMAN

Name: Galectin-3-binding protein

UniProtKB Accession Codes:

Q08380 Q7M4S0 Q9UCH8 Q9UCH9 Q9UCI0

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 2 CPTAC 5 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 5 EPD 1 Ensembl 1 EvolutionaryTrace 1 ExpressionAtlas 1 GO 11 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyConnect 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 6 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 5 PDBsum 2 PIR 2 PRIDE 1 PRINTS 1 PRO 1 PROSITE 3 PROSITE-ProRule 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 1 RefSeq 1 SIGNOR 1 SMART 2 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8390986

Title: Cloning and characterization of a human Mac-2-binding protein, a new member of the superfamily defined by the macrophage scavenger receptor cysteine-rich domain.

PubMed ID: 8390986

DOI: 10.1016/s0021-9258(19)85233-x

PubMed ID: 8034587

Title: The secreted tumor-associated antigen 90K is a potent immune stimulator.

PubMed ID: 8034587

DOI: 10.1016/s0021-9258(17)32322-0

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8454062

Title: Purification and characterization of a 90 kDa protein released from human tumors and tumor cell lines.

PubMed ID: 8454062

DOI: 10.1016/0014-5793(93)80037-u

PubMed ID: 8757764

Title: The 105-kDa basement membrane autoantigen p105 is N-terminally homologous to a tumor-associated antigen.

PubMed ID: 8757764

DOI: 10.1111/1523-1747.ep12329629

PubMed ID: 11867635

Title: Functional studies on recombinant domains of Mac-2-binding protein.

PubMed ID: 11867635

DOI: 10.1074/jbc.m200386200

PubMed ID: 11146440

Title: Glycoprotein 90K/MAC-2BP interacts with galectin-1 and mediates galectin-1-induced cell aggregation.

PubMed ID: 11146440

DOI: 10.1002/1097-0215(200002)9999:9999<::aid-ijc1022>3.3.co;2-q

PubMed ID: 15084671

Title: A proteomic analysis of human bile.

PubMed ID: 15084671

DOI: 10.1074/mcp.m400015-mcp200

PubMed ID: 16335952

Title: Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry.

PubMed ID: 16335952

DOI: 10.1021/pr0502065

PubMed ID: 16740002

Title: Identification of N-linked glycoproteins in human saliva by glycoprotein capture and mass spectrometry.

PubMed ID: 16740002

DOI: 10.1021/pr050492k

PubMed ID: 18780401

Title: Identification of N-linked glycoproteins in human milk by hydrophilic interaction liquid chromatography and mass spectrometry.

PubMed ID: 18780401

DOI: 10.1002/pmic.200701057

PubMed ID: 19159218

Title: Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry.

PubMed ID: 19159218

DOI: 10.1021/pr8008012

PubMed ID: 19139490

Title: A strategy for precise and large scale identification of core fucosylated glycoproteins.

PubMed ID: 19139490

DOI: 10.1074/mcp.m800504-mcp200

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 29162697

Title: EB1-binding-myomegalin protein complex promotes centrosomal microtubules functions.

PubMed ID: 29162697

DOI: 10.1073/pnas.1705682114

PubMed ID: 9501082

Title: Mac-2 binding protein is a cell-adhesive protein of the extracellular matrix which self-assembles into ring-like structures and binds beta1 integrins, collagens and fibronectin.

PubMed ID: 9501082

DOI: 10.1093/emboj/17.6.1606

Sequence Information:

  • Length: 585
  • Mass: 65331
  • Checksum: C488C2E99D77435B
  • Sequence:
    • MTPPRLFWVW LLVAGTQGVN DGDMRLADGG ATNQGRVEIF YRGQWGTVCD NLWDLTDASV 
VCRALGFENA TQALGRAAFG QGSGPIMLDE VQCTGTEASL ADCKSLGWLK SNCRHERDAG 
VVCTNETRST HTLDLSRELS EALGQIFDSQ RGCDLSISVN VQGEDALGFC GHTVILTANL 
EAQALWKEPG SNVTMSVDAE CVPMVRDLLR YFYSRRIDIT LSSVKCFHKL ASAYGARQLQ 
GYCASLFAIL LPQDPSFQMP LDLYAYAVAT GDALLEKLCL QFLAWNFEAL TQAEAWPSVP 
TDLLQLLLPR SDLAVPSELA LLKAVDTWSW GERASHEEVE GLVEKIRFPM MLPEELFELQ 
FNLSLYWSHE ALFQKKTLQA LEFHTVPFQL LARYKGLNLT EDTYKPRIYT SPTWSAFVTD 
SSWSARKSQL VYQSRRGPLV KYSSDYFQAP SDYRYYPYQS FQTPQHPSFL FQDKRVSWSL 
VYLPTIQSCW NYGFSCSSDE LPVLGLTKSG GSDRTIAYEN KALMLCEGLF VADVTDFEGW 
KAAIPSALDT NSSKSTSSFP CPAGHFNGFR TVIRPFYLTN SSGVD

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.