Details for: SOD3

Gene ID: 6649

Symbol: SOD3

Ensembl ID: ENSG00000109610

Description: superoxide dismutase 3

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: inflammatory cell (CL0009002)
    Fold Change: 3.22
    Marker Score: 1383
  • Cell Name: fibroblast of lung (CL0002553)
    Fold Change: 3
    Marker Score: 7846
  • Cell Name: fibroblast of connective tissue of glandular part of prostate (CL1000305)
    Fold Change: 2.94
    Marker Score: 1222
  • Cell Name: kidney interstitial cell (CL1000500)
    Fold Change: 2.84
    Marker Score: 2022
  • Cell Name: supporting cell (CL0000630)
    Fold Change: 2.81
    Marker Score: 5285
  • Cell Name: fibroblast of connective tissue of nonglandular part of prostate (CL1000304)
    Fold Change: 2.68
    Marker Score: 2286
  • Cell Name: renal interstitial pericyte (CL1001318)
    Fold Change: 2.59
    Marker Score: 2467
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 2.5
    Marker Score: 10799
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 2.44
    Marker Score: 1285
  • Cell Name: fibroblast of connective tissue of prostate (CL1000299)
    Fold Change: 2.39
    Marker Score: 596
  • Cell Name: prostate stromal cell (CL0002622)
    Fold Change: 2.37
    Marker Score: 596
  • Cell Name: uterine smooth muscle cell (CL0002601)
    Fold Change: 2.33
    Marker Score: 3033
  • Cell Name: muscle cell (CL0000187)
    Fold Change: 2.29
    Marker Score: 647
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 2.24
    Marker Score: 516
  • Cell Name: tracheobronchial smooth muscle cell (CL0019019)
    Fold Change: 2.24
    Marker Score: 657
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 2.21
    Marker Score: 75278
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: 2.13
    Marker Score: 2651
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 2.04
    Marker Score: 2117
  • Cell Name: type II pneumocyte (CL0002063)
    Fold Change: 2.01
    Marker Score: 13112
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: 1.87
    Marker Score: 1233
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 1.74
    Marker Score: 6834
  • Cell Name: smooth muscle cell of prostate (CL1000487)
    Fold Change: 1.72
    Marker Score: 439
  • Cell Name: blood vessel smooth muscle cell (CL0019018)
    Fold Change: 1.59
    Marker Score: 419
  • Cell Name: pericyte (CL0000669)
    Fold Change: 1.55
    Marker Score: 908
  • Cell Name: pancreatic stellate cell (CL0002410)
    Fold Change: 1.5
    Marker Score: 945.5
  • Cell Name: mural cell (CL0008034)
    Fold Change: 1.47
    Marker Score: 168095
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 1.43
    Marker Score: 599
  • Cell Name: bronchus fibroblast of lung (CL2000093)
    Fold Change: 1.4
    Marker Score: 1930
  • Cell Name: pneumocyte (CL0000322)
    Fold Change: 1.39
    Marker Score: 2228
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: 1.36
    Marker Score: 3647
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 1.35
    Marker Score: 858
  • Cell Name: fibroblast of breast (CL4006000)
    Fold Change: 1.35
    Marker Score: 769
  • Cell Name: fibroblast (CL0000057)
    Fold Change: 1.31
    Marker Score: 1261
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 1.3
    Marker Score: 1322
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 1.28
    Marker Score: 3127
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: 1.27
    Marker Score: 738
  • Cell Name: myofibroblast cell (CL0000186)
    Fold Change: 1.25
    Marker Score: 1548
  • Cell Name: adventitial cell (CL0002503)
    Fold Change: 1.21
    Marker Score: 298
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: 1.2
    Marker Score: 617.5
  • Cell Name: choroid plexus epithelial cell (CL0000706)
    Fold Change: 1.16
    Marker Score: 1067
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 1.14
    Marker Score: 4771
  • Cell Name: glandular epithelial cell (CL0000150)
    Fold Change: 1.12
    Marker Score: 2760
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: 1.12
    Marker Score: 3969
  • Cell Name: skin fibroblast (CL0002620)
    Fold Change: 1.11
    Marker Score: 289
  • Cell Name: stromal cell of lamina propria of small intestine (CL0009022)
    Fold Change: 1.1
    Marker Score: 247
  • Cell Name: type I pneumocyte (CL0002062)
    Fold Change: 1.05
    Marker Score: 1266
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 1.04
    Marker Score: 16703
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 1.03
    Marker Score: 35582
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 1.01
    Marker Score: 683
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71767
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 47993
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: 0.99
    Marker Score: 1580
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: 0.99
    Marker Score: 3654
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30406
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.98
    Marker Score: 503
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.97
    Marker Score: 456
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2410
  • Cell Name: fibrocyte (CL0000135)
    Fold Change: 0.95
    Marker Score: 293
  • Cell Name: bronchial smooth muscle cell (CL0002598)
    Fold Change: 0.93
    Marker Score: 264
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.93
    Marker Score: 617
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.92
    Marker Score: 370
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2739
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.91
    Marker Score: 5203
  • Cell Name: neural progenitor cell (CL0011020)
    Fold Change: 0.9
    Marker Score: 3494
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.9
    Marker Score: 323
  • Cell Name: stem cell of epidermis (CL1000428)
    Fold Change: 0.9
    Marker Score: 304
  • Cell Name: vascular associated smooth muscle cell (CL0000359)
    Fold Change: 0.89
    Marker Score: 408
  • Cell Name: epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 0.89
    Marker Score: 399
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5272
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.84
    Marker Score: 9489
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 0.83
    Marker Score: 1409.5
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.83
    Marker Score: 13006
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: 0.82
    Marker Score: 816
  • Cell Name: stromal cell (CL0000499)
    Fold Change: 0.81
    Marker Score: 953
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.81
    Marker Score: 618
  • Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
    Fold Change: 0.8
    Marker Score: 865
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1265
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.77
    Marker Score: 4656
  • Cell Name: reticular cell (CL0000432)
    Fold Change: 0.76
    Marker Score: 279
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.76
    Marker Score: 393
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.74
    Marker Score: 1743
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.74
    Marker Score: 674
  • Cell Name: epithelial cell of lung (CL0000082)
    Fold Change: 0.74
    Marker Score: 3872
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.74
    Marker Score: 471
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.73
    Marker Score: 336
  • Cell Name: smooth muscle cell of large intestine (CL1000279)
    Fold Change: 0.71
    Marker Score: 270
  • Cell Name: ionocyte (CL0005006)
    Fold Change: 0.7
    Marker Score: 211
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.69
    Marker Score: 178
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.69
    Marker Score: 1314
  • Cell Name: stem cell (CL0000034)
    Fold Change: 0.68
    Marker Score: 1624
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.67
    Marker Score: 279
  • Cell Name: ciliated epithelial cell (CL0000067)
    Fold Change: 0.67
    Marker Score: 306
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.66
    Marker Score: 316
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: 0.66
    Marker Score: 1084
  • Cell Name: thyroid follicular cell (CL0002258)
    Fold Change: 0.65
    Marker Score: 512
  • Cell Name: glandular cell of esophagus (CL0002657)
    Fold Change: 0.65
    Marker Score: 205
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: 0.65
    Marker Score: 358
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.64
    Marker Score: 1302
  • Cell Name: intestinal crypt stem cell of large intestine (CL0009016)
    Fold Change: 0.63
    Marker Score: 190
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: 0.63
    Marker Score: 413

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Other Information

**Key Characteristics:** SOD3 is a copper-zinc containing enzyme that catalyzes the dismutation of superoxide (O2-) into hydrogen peroxide (H2O2) and oxygen (O2). This process is essential for protecting cells from oxidative damage caused by ROS. SOD3 is predominantly expressed in extracellular tissues, including blood vessels, lung, prostate, kidney, and lymphoid organs. Its expression is also found in various cell types, including inflammatory cells, fibroblasts, and hematopoietic stem cells. **Pathways and Functions:** SOD3 plays a pivotal role in several cellular pathways, including: 1. **Detoxification of Reactive Oxygen Species (ROS):** SOD3 is the primary enzyme responsible for converting superoxide (O2-) into hydrogen peroxide (H2O2) and oxygen (O2), thereby neutralizing ROS and maintaining cellular homeostasis. 2. **Keap1-NFE2L2 Pathway:** SOD3 is a target of the NFE2L2 transcription factor, which regulates the expression of antioxidant and detoxification enzymes. This pathway is crucial for maintaining cellular antioxidant defenses and responding to oxidative stress. 3. **Molecular Adaptor Activity:** SOD3 can interact with various proteins, including NFE2L2, to modulate signaling pathways and regulate cellular responses to oxidative stress. 4. **Heparin Binding:** SOD3 is bound to heparin, a glycosaminoglycan, which enhances its stability and activity in the extracellular environment. **Clinical Significance:** Dysregulation of SOD3 expression or activity has been implicated in various diseases, including: 1. **Atherosclerosis:** SOD3 deficiency has been linked to increased oxidative stress and inflammation in atherosclerotic plaques. 2. **Prostate Cancer:** Overexpression of SOD3 has been observed in prostate cancer cells, suggesting a potential role in tumorigenesis. 3. **Kidney Disease:** SOD3 expression is reduced in kidney disease, leading to increased oxidative stress and inflammation. 4. **Respiratory Diseases:** SOD3 deficiency has been linked to chronic obstructive pulmonary disease (COPD) and other respiratory disorders. In conclusion, SOD3 is a vital enzyme that plays a crucial role in maintaining cellular homeostasis and responding to oxidative stress. Its dysregulation has been implicated in various diseases, highlighting the importance of SOD3 in human health and disease. Further research is needed to fully elucidate the mechanisms by which SOD3 regulates cellular responses to oxidative stress and to explore its potential as a therapeutic target for diseases associated with its dysregulation.

Genular Protein ID: 1174568994

Symbol: SODE_HUMAN

Name: Extracellular superoxide dismutase [Cu-Zn]

UniProtKB Accession Codes:

P08294 Q5U781 Q6FHA2

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BindingDB 1 BioCyc 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 ChEBI 14 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DisProt 1 DrugBank 1 EC 2 EMBL 5 EPD 1 Ensembl 1 EvolutionaryTrace 1 ExpressionAtlas 1 GO 13 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyConnect 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 MANE-Select 1 MIM 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 2 PDBsum 1 PIR 1 PRINTS 1 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 2 RefSeq 1 Rhea 1 SIGNOR 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 3476950

Title: Isolation and sequence of complementary DNA encoding human extracellular superoxide dismutase.

PubMed ID: 3476950

DOI: 10.1073/pnas.84.18.6340

PubMed ID: 7959763

Title: Extracellular superoxide dismutase (SOD3): tissue-specific expression, genomic characterization, and computer-assisted sequence analysis of the human EC SOD gene.

PubMed ID: 7959763

DOI: 10.1006/geno.1994.1357

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 1505778

Title: The site of nonenzymic glycation of human extracellular-superoxide dismutase in vitro.

PubMed ID: 1505778

DOI: 10.1016/0891-5849(92)90016-a

PubMed ID: 16087389

Title: Extracellular superoxide dismutase.

PubMed ID: 16087389

DOI: 10.1016/j.biocel.2005.06.012

PubMed ID: 16335952

Title: Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry.

PubMed ID: 16335952

DOI: 10.1021/pr0502065

PubMed ID: 16371425

Title: Essential role for the Menkes ATPase in activation of extracellular superoxide dismutase: implication for vascular oxidative stress.

PubMed ID: 16371425

DOI: 10.1096/fj.05-4564fje

PubMed ID: 19159218

Title: Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry.

PubMed ID: 19159218

DOI: 10.1021/pr8008012

PubMed ID: 19289127

Title: The structure of human extracellular copper-zinc superoxide dismutase at 1.7 A resolution: insights into heparin and collagen binding.

PubMed ID: 19289127

DOI: 10.1016/j.jmb.2009.03.026

PubMed ID: 8034674

Title: 10-fold increase in human plasma extracellular superoxide dismutase content caused by a mutation in heparin-binding domain.

PubMed ID: 8034674

DOI: 10.1016/s0021-9258(17)32289-5

PubMed ID: 7662997

Title: Molecular analysis of extracellular-superoxide dismutase gene associated with high level in serum.

PubMed ID: 7662997

DOI: 10.1007/bf01883574

PubMed ID: 8546689

Title: Substitution of glycine for arginine-213 in extracellular-superoxide dismutase impairs affinity for heparin and endothelial cell surface.

PubMed ID: 8546689

DOI: 10.1042/bj3130235

PubMed ID: 8864862

Title: An arginine-213 to glycine mutation in human extracellular-superoxide dismutase reduces susceptibility to trypsin-like proteinases.

PubMed ID: 8864862

DOI: 10.1093/oxfordjournals.jbchem.a021383

Sequence Information:

  • Length: 240
  • Mass: 25851
  • Checksum: 585B8DEBFC506CF4
  • Sequence:
    • MLALLCSCLL LAAGASDAWT GEDSAEPNSD SAEWIRDMYA KVTEIWQEVM QRRDDDGALH 
AACQVQPSAT LDAAQPRVTG VVLFRQLAPR AKLDAFFALE GFPTEPNSSS RAIHVHQFGD 
LSQGCESTGP HYNPLAVPHP QHPGDFGNFA VRDGSLWRYR AGLAASLAGP HSIVGRAVVV 
HAGEDDLGRG GNQASVENGN AGRRLACCVV GVCGPGLWER QAREHSERKK RRRESECKAA

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.