Details for: SOD3

Gene ID: 6649

Symbol: SOD3

Ensembl ID: ENSG00000109610

Description: superoxide dismutase 3

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 56.4472
    Cell Significance Index: -26.6500
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: 17.1813
    Cell Significance Index: 144.3200
  • Cell Name: pulmonary interstitial fibroblast (CL0002241)
    Fold Change: 7.6874
    Cell Significance Index: 47.5600
  • Cell Name: perivascular cell (CL4033054)
    Fold Change: 5.3972
    Cell Significance Index: 24.9200
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 3.3190
    Cell Significance Index: 95.1400
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 2.9167
    Cell Significance Index: 79.3900
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 1.9297
    Cell Significance Index: 34.1000
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 1.9268
    Cell Significance Index: 224.5500
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: 1.5026
    Cell Significance Index: 24.7600
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 1.5018
    Cell Significance Index: 31.9900
  • Cell Name: peg cell (CL4033014)
    Fold Change: 1.1299
    Cell Significance Index: 26.1100
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.9185
    Cell Significance Index: 99.9100
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.8869
    Cell Significance Index: 144.2500
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.7468
    Cell Significance Index: 102.5600
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.7241
    Cell Significance Index: 395.4500
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.4989
    Cell Significance Index: 34.5000
  • Cell Name: thyroid follicular cell (CL0002258)
    Fold Change: 0.4602
    Cell Significance Index: 4.8900
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.3218
    Cell Significance Index: 290.5400
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: 0.2716
    Cell Significance Index: 5.3000
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: 0.2140
    Cell Significance Index: 1.4500
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.1674
    Cell Significance Index: 16.5600
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.1626
    Cell Significance Index: 30.9500
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.1085
    Cell Significance Index: 8.0900
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.0991
    Cell Significance Index: 43.8300
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.0765
    Cell Significance Index: 57.8800
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.0652
    Cell Significance Index: 47.8300
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.0363
    Cell Significance Index: 0.9700
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.0302
    Cell Significance Index: 5.4400
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: 0.0213
    Cell Significance Index: 1.0800
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.0062
    Cell Significance Index: 0.4400
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0048
    Cell Significance Index: 9.0100
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0040
    Cell Significance Index: -0.1400
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.0056
    Cell Significance Index: -0.1600
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.0088
    Cell Significance Index: -0.2200
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: -0.0105
    Cell Significance Index: -0.1800
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.0134
    Cell Significance Index: -0.2900
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0179
    Cell Significance Index: -2.2900
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0181
    Cell Significance Index: -33.3400
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0217
    Cell Significance Index: -33.4800
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0251
    Cell Significance Index: -34.1000
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0276
    Cell Significance Index: -17.5400
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0347
    Cell Significance Index: -3.9800
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0417
    Cell Significance Index: -30.9200
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0440
    Cell Significance Index: -19.9500
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0481
    Cell Significance Index: -30.0500
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0491
    Cell Significance Index: -27.7100
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0505
    Cell Significance Index: -6.5200
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0690
    Cell Significance Index: -8.4900
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: -0.0730
    Cell Significance Index: -1.1300
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0762
    Cell Significance Index: -27.3300
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.0929
    Cell Significance Index: -4.2100
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0930
    Cell Significance Index: -26.7500
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0932
    Cell Significance Index: -15.9200
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.1042
    Cell Significance Index: -15.1500
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.1233
    Cell Significance Index: -24.4600
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.1405
    Cell Significance Index: -28.1900
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.1410
    Cell Significance Index: -4.5200
  • Cell Name: kidney interstitial cell (CL1000500)
    Fold Change: -0.1423
    Cell Significance Index: -1.0700
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1477
    Cell Significance Index: -31.1100
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.1622
    Cell Significance Index: -16.5700
  • Cell Name: keratocyte (CL0002363)
    Fold Change: -0.1721
    Cell Significance Index: -2.7300
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -0.1749
    Cell Significance Index: -2.6200
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.1784
    Cell Significance Index: -3.7000
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.1811
    Cell Significance Index: -7.4200
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.1951
    Cell Significance Index: -9.1700
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.2029
    Cell Significance Index: -12.4400
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.2403
    Cell Significance Index: -25.0200
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.2639
    Cell Significance Index: -31.1200
  • Cell Name: fibroblast of connective tissue of glandular part of prostate (CL1000305)
    Fold Change: -0.2761
    Cell Significance Index: -3.0500
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.2850
    Cell Significance Index: -4.7700
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: -0.2915
    Cell Significance Index: -2.8100
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.3251
    Cell Significance Index: -25.7500
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.3504
    Cell Significance Index: -26.8900
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.3698
    Cell Significance Index: -7.7400
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.4129
    Cell Significance Index: -11.5400
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.4164
    Cell Significance Index: -28.0000
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.4352
    Cell Significance Index: -27.4300
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.4384
    Cell Significance Index: -4.9800
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.4886
    Cell Significance Index: -25.4500
  • Cell Name: skin fibroblast (CL0002620)
    Fold Change: -0.4894
    Cell Significance Index: -1.1300
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.5124
    Cell Significance Index: -23.8900
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.5462
    Cell Significance Index: -30.6500
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.5465
    Cell Significance Index: -33.5900
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.5916
    Cell Significance Index: -31.0600
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.5933
    Cell Significance Index: -15.2500
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.6370
    Cell Significance Index: -33.0900
  • Cell Name: fibroblast of connective tissue of nonglandular part of prostate (CL1000304)
    Fold Change: -0.6670
    Cell Significance Index: -7.2800
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.7099
    Cell Significance Index: -31.4000
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: -0.7348
    Cell Significance Index: -9.4100
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.7386
    Cell Significance Index: -27.1200
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.7479
    Cell Significance Index: -28.3200
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.8056
    Cell Significance Index: -28.2200
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.8382
    Cell Significance Index: -36.4500
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.8406
    Cell Significance Index: -29.2100
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.8674
    Cell Significance Index: -28.4000
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.8939
    Cell Significance Index: -28.4700
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -0.9628
    Cell Significance Index: -20.5800
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.9867
    Cell Significance Index: -26.4400
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.9889
    Cell Significance Index: -28.2200
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.9927
    Cell Significance Index: -29.2400

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** SOD3 is a copper-zinc containing enzyme that catalyzes the dismutation of superoxide (O2-) into hydrogen peroxide (H2O2) and oxygen (O2). This process is essential for protecting cells from oxidative damage caused by ROS. SOD3 is predominantly expressed in extracellular tissues, including blood vessels, lung, prostate, kidney, and lymphoid organs. Its expression is also found in various cell types, including inflammatory cells, fibroblasts, and hematopoietic stem cells. **Pathways and Functions:** SOD3 plays a pivotal role in several cellular pathways, including: 1. **Detoxification of Reactive Oxygen Species (ROS):** SOD3 is the primary enzyme responsible for converting superoxide (O2-) into hydrogen peroxide (H2O2) and oxygen (O2), thereby neutralizing ROS and maintaining cellular homeostasis. 2. **Keap1-NFE2L2 Pathway:** SOD3 is a target of the NFE2L2 transcription factor, which regulates the expression of antioxidant and detoxification enzymes. This pathway is crucial for maintaining cellular antioxidant defenses and responding to oxidative stress. 3. **Molecular Adaptor Activity:** SOD3 can interact with various proteins, including NFE2L2, to modulate signaling pathways and regulate cellular responses to oxidative stress. 4. **Heparin Binding:** SOD3 is bound to heparin, a glycosaminoglycan, which enhances its stability and activity in the extracellular environment. **Clinical Significance:** Dysregulation of SOD3 expression or activity has been implicated in various diseases, including: 1. **Atherosclerosis:** SOD3 deficiency has been linked to increased oxidative stress and inflammation in atherosclerotic plaques. 2. **Prostate Cancer:** Overexpression of SOD3 has been observed in prostate cancer cells, suggesting a potential role in tumorigenesis. 3. **Kidney Disease:** SOD3 expression is reduced in kidney disease, leading to increased oxidative stress and inflammation. 4. **Respiratory Diseases:** SOD3 deficiency has been linked to chronic obstructive pulmonary disease (COPD) and other respiratory disorders. In conclusion, SOD3 is a vital enzyme that plays a crucial role in maintaining cellular homeostasis and responding to oxidative stress. Its dysregulation has been implicated in various diseases, highlighting the importance of SOD3 in human health and disease. Further research is needed to fully elucidate the mechanisms by which SOD3 regulates cellular responses to oxidative stress and to explore its potential as a therapeutic target for diseases associated with its dysregulation.

Genular Protein ID: 1174568994

Symbol: SODE_HUMAN

Name: Extracellular superoxide dismutase [Cu-Zn]

UniProtKB Accession Codes:

P08294 Q5U781 Q6FHA2

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BindingDB 1 BioCyc 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChEBI 14 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DisProt 1 DrugBank 1 EC 2 EMBL 5 Ensembl 1 EvolutionaryTrace 1 ExpressionAtlas 1 GO 13 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyConnect 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 1 PDBsum 1 PIR 1 PRINTS 1 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 2 RefSeq 1 Rhea 1 SIGNOR 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 3476950

Title: Isolation and sequence of complementary DNA encoding human extracellular superoxide dismutase.

PubMed ID: 3476950

DOI: 10.1073/pnas.84.18.6340

PubMed ID: 7959763

Title: Extracellular superoxide dismutase (SOD3): tissue-specific expression, genomic characterization, and computer-assisted sequence analysis of the human EC SOD gene.

PubMed ID: 7959763

DOI: 10.1006/geno.1994.1357

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 1505778

Title: The site of nonenzymic glycation of human extracellular-superoxide dismutase in vitro.

PubMed ID: 1505778

DOI: 10.1016/0891-5849(92)90016-a

PubMed ID: 16087389

Title: Extracellular superoxide dismutase.

PubMed ID: 16087389

DOI: 10.1016/j.biocel.2005.06.012

PubMed ID: 16335952

Title: Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry.

PubMed ID: 16335952

DOI: 10.1021/pr0502065

PubMed ID: 16371425

Title: Essential role for the Menkes ATPase in activation of extracellular superoxide dismutase: implication for vascular oxidative stress.

PubMed ID: 16371425

DOI: 10.1096/fj.05-4564fje

PubMed ID: 19159218

Title: Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry.

PubMed ID: 19159218

DOI: 10.1021/pr8008012

PubMed ID: 19289127

Title: The structure of human extracellular copper-zinc superoxide dismutase at 1.7 A resolution: insights into heparin and collagen binding.

PubMed ID: 19289127

DOI: 10.1016/j.jmb.2009.03.026

PubMed ID: 8034674

Title: 10-fold increase in human plasma extracellular superoxide dismutase content caused by a mutation in heparin-binding domain.

PubMed ID: 8034674

DOI: 10.1016/s0021-9258(17)32289-5

PubMed ID: 7662997

Title: Molecular analysis of extracellular-superoxide dismutase gene associated with high level in serum.

PubMed ID: 7662997

DOI: 10.1007/bf01883574

PubMed ID: 8546689

Title: Substitution of glycine for arginine-213 in extracellular-superoxide dismutase impairs affinity for heparin and endothelial cell surface.

PubMed ID: 8546689

DOI: 10.1042/bj3130235

PubMed ID: 8864862

Title: An arginine-213 to glycine mutation in human extracellular-superoxide dismutase reduces susceptibility to trypsin-like proteinases.

PubMed ID: 8864862

DOI: 10.1093/oxfordjournals.jbchem.a021383

Sequence Information:

  • Length: 240
  • Mass: 25851
  • Checksum: 585B8DEBFC506CF4
  • Sequence:
    • MLALLCSCLL LAAGASDAWT GEDSAEPNSD SAEWIRDMYA KVTEIWQEVM QRRDDDGALH 
AACQVQPSAT LDAAQPRVTG VVLFRQLAPR AKLDAFFALE GFPTEPNSSS RAIHVHQFGD 
LSQGCESTGP HYNPLAVPHP QHPGDFGNFA VRDGSLWRYR AGLAASLAGP HSIVGRAVVV 
HAGEDDLGRG GNQASVENGN AGRRLACCVV GVCGPGLWER QAREHSERKK RRRESECKAA

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.