Details for: NODAL

Gene ID: 4838

Symbol: NODAL

Ensembl ID: ENSG00000156574

Description: nodal growth differentiation factor

Associated with

  • Developmental biology
    (R-HSA-1266738)
  • Regulation of signaling by nodal
    (R-HSA-1433617)
  • Signaling by nodal
    (R-HSA-1181150)
  • Axial mesodermal cell fate specification
    (GO:0048327)
  • Brain development
    (GO:0007420)
  • Cell migration involved in gastrulation
    (GO:0042074)
  • Cell population proliferation
    (GO:0008283)
  • Cytokine activity
    (GO:0005125)
  • Determination of left/right asymmetry in lateral mesoderm
    (GO:0003140)
  • Digestive tract morphogenesis
    (GO:0048546)
  • Embryonic cranial skeleton morphogenesis
    (GO:0048701)
  • Embryonic pattern specification
    (GO:0009880)
  • Embryonic placenta development
    (GO:0001892)
  • Embryonic process involved in female pregnancy
    (GO:0060136)
  • Endodermal cell differentiation
    (GO:0035987)
  • Epiblast cell-extraembryonic ectoderm cell signaling involved in anterior/posterior axis specification
    (GO:0060802)
  • Extracellular space
    (GO:0005615)
  • Floor plate morphogenesis
    (GO:0033505)
  • Formation of anatomical boundary
    (GO:0048859)
  • Germ cell development
    (GO:0007281)
  • Growth factor activity
    (GO:0008083)
  • Heart looping
    (GO:0001947)
  • Inhibition of neuroepithelial cell differentiation
    (GO:0002085)
  • Left lung morphogenesis
    (GO:0060460)
  • Liver development
    (GO:0001889)
  • Maternal placenta development
    (GO:0001893)
  • Maternal process involved in parturition
    (GO:0060137)
  • Mesendoderm development
    (GO:0048382)
  • Morphogen activity
    (GO:0016015)
  • Negative regulation of androgen receptor signaling pathway
    (GO:0060766)
  • Negative regulation of cell development
    (GO:0010721)
  • Negative regulation of chorionic trophoblast cell proliferation
    (GO:1901383)
  • Negative regulation of transcription by rna polymerase ii
    (GO:0000122)
  • Negative regulation of trophoblast cell migration
    (GO:1901164)
  • Neural fold formation
    (GO:0001842)
  • Nodal signaling pathway
    (GO:0038092)
  • Placenta development
    (GO:0001890)
  • Polarity specification of proximal/distal axis
    (GO:0010085)
  • Positive regulation of activin receptor signaling pathway
    (GO:0032927)
  • Positive regulation of angiogenesis
    (GO:0045766)
  • Positive regulation of cell-cell adhesion
    (GO:0022409)
  • Positive regulation of cysteine-type endopeptidase activity involved in apoptotic process
    (GO:0043280)
  • Positive regulation of dna-binding transcription factor activity
    (GO:0051091)
  • Positive regulation of epithelial cell proliferation
    (GO:0050679)
  • Positive regulation of erk1 and erk2 cascade
    (GO:0070374)
  • Positive regulation of smad protein signal transduction
    (GO:0060391)
  • Positive regulation of transcription by rna polymerase ii
    (GO:0045944)
  • Positive regulation of vascular endothelial growth factor production
    (GO:0010575)
  • Primitive streak formation
    (GO:0090009)
  • Protein binding
    (GO:0005515)
  • Regulation of gastrulation
    (GO:0010470)
  • Regulation of stem cell population maintenance
    (GO:2000036)
  • Somatic stem cell population maintenance
    (GO:0035019)
  • Transforming growth factor beta receptor signaling pathway
    (GO:0007179)
  • Trophectodermal cellular morphogenesis
    (GO:0001831)
  • Type i activin receptor binding
    (GO:0070698)
  • Vasculature development
    (GO:0001944)

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: amacrine cell (CL0000561)
    Fold Change: 9.48
    Marker Score: 30377
  • Cell Name: ON-bipolar cell (CL0000749)
    Fold Change: 5.65
    Marker Score: 16487
  • Cell Name: OFF-bipolar cell (CL0000750)
    Fold Change: 3.8
    Marker Score: 11283.5
  • Cell Name: retinal bipolar neuron (CL0000748)
    Fold Change: 3.56
    Marker Score: 30070
  • Cell Name: retinal cone cell (CL0000573)
    Fold Change: 2.11
    Marker Score: 6051
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 1.93
    Marker Score: 5500
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: 1.73
    Marker Score: 961
  • Cell Name: conventional dendritic cell (CL0000990)
    Fold Change: 1.67
    Marker Score: 1149.5
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 1.49
    Marker Score: 2817
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 1.37
    Marker Score: 869
  • Cell Name: retina horizontal cell (CL0000745)
    Fold Change: 1.33
    Marker Score: 1273
  • Cell Name: goblet cell (CL0000160)
    Fold Change: 1.13
    Marker Score: 7531
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.02
    Marker Score: 15976.5
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71821
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48044.5
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30408
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.96
    Marker Score: 2443
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.94
    Marker Score: 5336
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.92
    Marker Score: 2743
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5287
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.82
    Marker Score: 627
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1263
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.78
    Marker Score: 708
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.76
    Marker Score: 396
  • Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
    Fold Change: 0.72
    Marker Score: 1482
  • Cell Name: fast muscle cell (CL0000190)
    Fold Change: 0.71
    Marker Score: 214
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.71
    Marker Score: 337
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.7
    Marker Score: 179
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 0.63
    Marker Score: 1587
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.61
    Marker Score: 1243
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: 0.58
    Marker Score: 936
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.58
    Marker Score: 465
  • Cell Name: neural progenitor cell (CL0011020)
    Fold Change: 0.57
    Marker Score: 2203
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.56
    Marker Score: 148
  • Cell Name: neutrophil (CL0000775)
    Fold Change: 0.54
    Marker Score: 328.5
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: 0.49
    Marker Score: 474
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 0.48
    Marker Score: 253
  • Cell Name: epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 0.4
    Marker Score: 178
  • Cell Name: primordial germ cell (CL0000670)
    Fold Change: 0.38
    Marker Score: 472
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.37
    Marker Score: 210
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 0.37
    Marker Score: 371
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.37
    Marker Score: 163
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.34
    Marker Score: 205
  • Cell Name: germ cell (CL0000586)
    Fold Change: 0.33
    Marker Score: 571
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.28
    Marker Score: 119
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.26
    Marker Score: 175
  • Cell Name: melanocyte (CL0000148)
    Fold Change: 0.26
    Marker Score: 105
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 0.26
    Marker Score: 136.5
  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.25
    Marker Score: 146
  • Cell Name: macrophage (CL0000235)
    Fold Change: 0.25
    Marker Score: 280
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.22
    Marker Score: 130
  • Cell Name: renal beta-intercalated cell (CL0002201)
    Fold Change: 0.2
    Marker Score: 62
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: 0.19
    Marker Score: 103
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: 0.19
    Marker Score: 49
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.18
    Marker Score: 1073
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 0.18
    Marker Score: 57
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.15
    Marker Score: 47
  • Cell Name: papillary tips cell (CL1000597)
    Fold Change: 0.15
    Marker Score: 30
  • Cell Name: plasma cell (CL0000786)
    Fold Change: 0.15
    Marker Score: 163
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.14
    Marker Score: 341
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.14
    Marker Score: 604
  • Cell Name: B cell (CL0000236)
    Fold Change: 0.14
    Marker Score: 131
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 0.13
    Marker Score: 117
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: 0.13
    Marker Score: 161
  • Cell Name: OFF retinal ganglion cell (CL4023033)
    Fold Change: 0.12
    Marker Score: 51
  • Cell Name: epithelial cell of glomerular capsule (CL1000450)
    Fold Change: 0.12
    Marker Score: 30
  • Cell Name: bronchial epithelial cell (CL0002328)
    Fold Change: 0.11
    Marker Score: 29
  • Cell Name: lung goblet cell (CL1000143)
    Fold Change: 0.11
    Marker Score: 31
  • Cell Name: blood vessel endothelial cell (CL0000071)
    Fold Change: 0.11
    Marker Score: 108
  • Cell Name: tracheobronchial smooth muscle cell (CL0019019)
    Fold Change: 0.11
    Marker Score: 31
  • Cell Name: fibroblast (CL0000057)
    Fold Change: 0.11
    Marker Score: 102
  • Cell Name: Schwann cell (CL0002573)
    Fold Change: 0.1
    Marker Score: 36
  • Cell Name: T-helper 17 cell (CL0000899)
    Fold Change: 0.1
    Marker Score: 68
  • Cell Name: adipocyte of epicardial fat of left ventricle (CL1000311)
    Fold Change: 0.1
    Marker Score: 27
  • Cell Name: parietal epithelial cell (CL1000452)
    Fold Change: 0.1
    Marker Score: 37
  • Cell Name: skin fibroblast (CL0002620)
    Fold Change: 0.1
    Marker Score: 26
  • Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
    Fold Change: 0.1
    Marker Score: 58
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 0.1
    Marker Score: 85
  • Cell Name: pericyte (CL0000669)
    Fold Change: 0.1
    Marker Score: 57
  • Cell Name: epicardial adipocyte (CL1000309)
    Fold Change: 0.09
    Marker Score: 46
  • Cell Name: mesothelial cell of epicardium (CL0011019)
    Fold Change: 0.09
    Marker Score: 30
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: 0.09
    Marker Score: 61
  • Cell Name: central nervous system macrophage (CL0000878)
    Fold Change: 0.09
    Marker Score: 46
  • Cell Name: ON retinal ganglion cell (CL4023032)
    Fold Change: 0.09
    Marker Score: 25
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.09
    Marker Score: 53
  • Cell Name: smooth muscle cell of prostate (CL1000487)
    Fold Change: 0.09
    Marker Score: 23
  • Cell Name: endothelial cell of artery (CL1000413)
    Fold Change: 0.09
    Marker Score: 36
  • Cell Name: interstitial cell of Cajal (CL0002088)
    Fold Change: 0.09
    Marker Score: 30
  • Cell Name: renal principal cell (CL0005009)
    Fold Change: 0.09
    Marker Score: 66
  • Cell Name: exhausted T cell (CL0011025)
    Fold Change: 0.09
    Marker Score: 49
  • Cell Name: endothelial cell of lymphatic vessel (CL0002138)
    Fold Change: 0.08
    Marker Score: 52
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.08
    Marker Score: 96
  • Cell Name: podocyte (CL0000653)
    Fold Change: 0.08
    Marker Score: 28
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.08
    Marker Score: 29
  • Cell Name: innate lymphoid cell (CL0001065)
    Fold Change: 0.08
    Marker Score: 27
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: 0.07
    Marker Score: 43
  • Cell Name: oocyte (CL0000023)
    Fold Change: 0.07
    Marker Score: 18
  • Cell Name: T cell (CL0000084)
    Fold Change: 0.07
    Marker Score: 122
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: 0.07
    Marker Score: 97.5
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: 0.07
    Marker Score: 249

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Other Information

**Key characteristics** - The NODAL gene is a transcription factor that is highly expressed in the developing embryo. - It is involved in the regulation of EMT, which is the process by which epithelial cells lose their epithelial characteristics and become mesenchymal cells. - NODAL is also involved in the development of the heart, liver, placenta, and other tissues. **Pathways and functions** - NODAL is a key regulator of the cytokine activity of the WNT signaling pathway. - It is also involved in the regulation of the TGF-beta signaling pathway, the BMP signaling pathway, and the Notch signaling pathway. - NODAL also plays a role in the regulation of tissue morphogenesis, cell migration, and differentiation. **Clinical significance** - Mutations in the NODAL gene have been linked to a number of human diseases, including heart defects, intellectual disability, and cancer. - The development of drugs that target the NODAL gene has been investigated as a potential treatment for these diseases. **Additional information** - The NODAL gene was first identified in a screen for genes that are expressed in the developing heart. - It is a member of the nodal family of transcription factors, which are involved in a variety of developmental processes. - NODAL is a highly conserved gene, with a similar gene found in mice and zebrafish.

Genular Protein ID: 1045029380

Symbol: NODAL_HUMAN

Name: Nodal homolog

UniProtKB Accession Codes:

Q96S42 Q2M3A5 Q8N4V3

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 5 Ensembl 1 ExpressionAtlas 1 GO 54 Gene3D 1 GeneCards 1 GeneReviews 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 IDEAL 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 3 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 8 OrthoDB 1 PANTHER 2 PDB 2 PDBsum 1 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 2 RefSeq 1 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 neXtProt 1

Citations:

PubMed ID: 15164054

Title: The DNA sequence and comparative analysis of human chromosome 10.

PubMed ID: 15164054

DOI: 10.1038/nature02462

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9354794

Title: X-linked situs abnormalities result from mutations in ZIC3.

PubMed ID: 9354794

DOI: 10.1038/ng1197-305

PubMed ID: 16959974

Title: The consensus coding sequences of human breast and colorectal cancers.

PubMed ID: 16959974

DOI: 10.1126/science.1133427

PubMed ID: 19064609

Title: Identification and functional characterization of NODAL rare variants in heterotaxy and isolated cardiovascular malformations.

PubMed ID: 19064609

DOI: 10.1093/hmg/ddn411

Sequence Information:

  • Length: 347
  • Mass: 39561
  • Checksum: 0D52352B9711650C
  • Sequence:
    • MHAHCLPFLL HAWWALLQAG AATVATALLR TRGQPSSPSP LAYMLSLYRD PLPRADIIRS 
LQAEDVAVDG QNWTFAFDFS FLSQQEDLAW AELRLQLSSP VDLPTEGSLA IEIFHQPKPD 
TEQASDSCLE RFQMDLFTVT LSQVTFSLGS MVLEVTRPLS KWLKHPGALE KQMSRVAGEC 
WPRPPTPPAT NVLLMLYSNL SQEQRQLGGS TLLWEAESSW RAQEGQLSWE WGKRHRRHHL 
PDRSQLCRKV KFQVDFNLIG WGSWIIYPKQ YNAYRCEGEC PNPVGEEFHP TNHAYIQSLL 
KRYQPHRVPS TCCAPVKTKP LSMLYVDNGR VLLDHHKDMI VEECGCL

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.