Details for: NODAL

Gene ID: 4838

Symbol: NODAL

Ensembl ID: ENSG00000156574

Description: nodal growth differentiation factor

Associated with

  • Developmental biology
    (R-HSA-1266738)
  • Regulation of signaling by nodal
    (R-HSA-1433617)
  • Signaling by nodal
    (R-HSA-1181150)
  • Axial mesodermal cell fate specification
    (GO:0048327)
  • Brain development
    (GO:0007420)
  • Cell migration involved in gastrulation
    (GO:0042074)
  • Cell population proliferation
    (GO:0008283)
  • Cytokine activity
    (GO:0005125)
  • Determination of left/right asymmetry in lateral mesoderm
    (GO:0003140)
  • Digestive tract morphogenesis
    (GO:0048546)
  • Embryonic cranial skeleton morphogenesis
    (GO:0048701)
  • Embryonic pattern specification
    (GO:0009880)
  • Embryonic placenta development
    (GO:0001892)
  • Embryonic process involved in female pregnancy
    (GO:0060136)
  • Endodermal cell differentiation
    (GO:0035987)
  • Epiblast cell-extraembryonic ectoderm cell signaling involved in anterior/posterior axis specification
    (GO:0060802)
  • Extracellular space
    (GO:0005615)
  • Floor plate morphogenesis
    (GO:0033505)
  • Formation of anatomical boundary
    (GO:0048859)
  • Germ cell development
    (GO:0007281)
  • Growth factor activity
    (GO:0008083)
  • Heart looping
    (GO:0001947)
  • Inhibition of neuroepithelial cell differentiation
    (GO:0002085)
  • Left lung morphogenesis
    (GO:0060460)
  • Liver development
    (GO:0001889)
  • Maternal placenta development
    (GO:0001893)
  • Maternal process involved in parturition
    (GO:0060137)
  • Mesendoderm development
    (GO:0048382)
  • Morphogen activity
    (GO:0016015)
  • Negative regulation of androgen receptor signaling pathway
    (GO:0060766)
  • Negative regulation of cell development
    (GO:0010721)
  • Negative regulation of chorionic trophoblast cell proliferation
    (GO:1901383)
  • Negative regulation of transcription by rna polymerase ii
    (GO:0000122)
  • Negative regulation of trophoblast cell migration
    (GO:1901164)
  • Neural fold formation
    (GO:0001842)
  • Nodal signaling pathway
    (GO:0038092)
  • Placenta development
    (GO:0001890)
  • Polarity specification of proximal/distal axis
    (GO:0010085)
  • Positive regulation of activin receptor signaling pathway
    (GO:0032927)
  • Positive regulation of angiogenesis
    (GO:0045766)
  • Positive regulation of cell-cell adhesion
    (GO:0022409)
  • Positive regulation of cysteine-type endopeptidase activity involved in apoptotic process
    (GO:0043280)
  • Positive regulation of dna-binding transcription factor activity
    (GO:0051091)
  • Positive regulation of epithelial cell proliferation
    (GO:0050679)
  • Positive regulation of erk1 and erk2 cascade
    (GO:0070374)
  • Positive regulation of smad protein signal transduction
    (GO:0060391)
  • Positive regulation of transcription by rna polymerase ii
    (GO:0045944)
  • Positive regulation of vascular endothelial growth factor production
    (GO:0010575)
  • Primitive streak formation
    (GO:0090009)
  • Protein binding
    (GO:0005515)
  • Regulation of gastrulation
    (GO:0010470)
  • Regulation of stem cell population maintenance
    (GO:2000036)
  • Somatic stem cell population maintenance
    (GO:0035019)
  • Transforming growth factor beta receptor signaling pathway
    (GO:0007179)
  • Trophectodermal cellular morphogenesis
    (GO:0001831)
  • Type i activin receptor binding
    (GO:0070698)
  • Vasculature development
    (GO:0001944)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: 0.1734
    Cell Significance Index: 4.2000
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 0.1447
    Cell Significance Index: 2.4800
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 0.1351
    Cell Significance Index: 3.3700
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: 0.0882
    Cell Significance Index: 0.7500
  • Cell Name: helper T cell (CL0000912)
    Fold Change: 0.0866
    Cell Significance Index: 1.2300
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: 0.0862
    Cell Significance Index: 1.2400
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.0704
    Cell Significance Index: 12.6900
  • Cell Name: adipocyte of breast (CL0002617)
    Fold Change: 0.0643
    Cell Significance Index: 0.8100
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 0.0521
    Cell Significance Index: 0.4800
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.0497
    Cell Significance Index: 1.0300
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 0.0490
    Cell Significance Index: 1.2600
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.0391
    Cell Significance Index: 3.0000
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.0385
    Cell Significance Index: 7.6400
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: 0.0325
    Cell Significance Index: 0.2200
  • Cell Name: fast muscle cell (CL0000190)
    Fold Change: 0.0305
    Cell Significance Index: 0.4000
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 0.0292
    Cell Significance Index: 4.2500
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.0273
    Cell Significance Index: 1.6800
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: 0.0169
    Cell Significance Index: 0.3300
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 0.0151
    Cell Significance Index: 0.1800
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.0146
    Cell Significance Index: 0.3200
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.0128
    Cell Significance Index: 0.7200
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.0086
    Cell Significance Index: 1.7300
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0066
    Cell Significance Index: 12.4800
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.0061
    Cell Significance Index: 0.7500
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.0049
    Cell Significance Index: 0.6300
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0039
    Cell Significance Index: 5.9300
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0027
    Cell Significance Index: 1.7300
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0020
    Cell Significance Index: 3.7600
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0017
    Cell Significance Index: 2.3400
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 0.0006
    Cell Significance Index: 0.0100
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0004
    Cell Significance Index: 0.1600
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0021
    Cell Significance Index: -0.9500
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0028
    Cell Significance Index: -2.1000
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0030
    Cell Significance Index: -2.2600
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0033
    Cell Significance Index: -0.9600
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0037
    Cell Significance Index: -0.6400
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0037
    Cell Significance Index: -2.0300
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0039
    Cell Significance Index: -2.1800
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: -0.0041
    Cell Significance Index: -0.0300
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0107
    Cell Significance Index: -2.2500
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: -0.0108
    Cell Significance Index: -0.1600
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.0119
    Cell Significance Index: -0.6200
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0145
    Cell Significance Index: -1.9900
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0179
    Cell Significance Index: -1.8600
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0184
    Cell Significance Index: -1.2400
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0184
    Cell Significance Index: -0.8600
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0191
    Cell Significance Index: -2.1900
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0209
    Cell Significance Index: -2.1400
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: -0.0237
    Cell Significance Index: -0.7500
  • Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
    Fold Change: -0.0251
    Cell Significance Index: -0.2600
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.0254
    Cell Significance Index: -0.6100
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: -0.0277
    Cell Significance Index: -0.4000
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.0294
    Cell Significance Index: -1.3000
  • Cell Name: germ cell (CL0000586)
    Fold Change: -0.0324
    Cell Significance Index: -0.2500
  • Cell Name: neural progenitor cell (CL0011020)
    Fold Change: -0.0334
    Cell Significance Index: -0.3300
  • Cell Name: cell of skeletal muscle (CL0000188)
    Fold Change: -0.0336
    Cell Significance Index: -0.4300
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0338
    Cell Significance Index: -1.5900
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.0349
    Cell Significance Index: -1.3200
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.0358
    Cell Significance Index: -1.0500
  • Cell Name: slow muscle cell (CL0000189)
    Fold Change: -0.0374
    Cell Significance Index: -0.5600
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.0392
    Cell Significance Index: -1.7100
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: -0.0398
    Cell Significance Index: -0.6700
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: -0.0416
    Cell Significance Index: -0.4300
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.0420
    Cell Significance Index: -0.6200
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.0429
    Cell Significance Index: -2.2500
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0440
    Cell Significance Index: -1.2300
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: -0.0445
    Cell Significance Index: -0.7200
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.0448
    Cell Significance Index: -1.2000
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: -0.0455
    Cell Significance Index: -1.1100
  • Cell Name: OFF midget ganglion cell (CL4033047)
    Fold Change: -0.0481
    Cell Significance Index: -0.6000
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.0492
    Cell Significance Index: -1.3400
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.0494
    Cell Significance Index: -1.7300
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.0510
    Cell Significance Index: -1.4700
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0521
    Cell Significance Index: -1.6600
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.0528
    Cell Significance Index: -1.7300
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: -0.0532
    Cell Significance Index: -0.7300
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0542
    Cell Significance Index: -2.7400
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0552
    Cell Significance Index: -1.9400
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.0561
    Cell Significance Index: -1.9500
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: -0.0564
    Cell Significance Index: -0.7600
  • Cell Name: ON midget ganglion cell (CL4033046)
    Fold Change: -0.0570
    Cell Significance Index: -0.7200
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0577
    Cell Significance Index: -1.5400
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: -0.0591
    Cell Significance Index: -0.7700
  • Cell Name: primordial germ cell (CL0000670)
    Fold Change: -0.0599
    Cell Significance Index: -0.3700
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.0606
    Cell Significance Index: -1.7300
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.0623
    Cell Significance Index: -1.8400
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.0623
    Cell Significance Index: -0.8500
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.0631
    Cell Significance Index: -1.3200
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: -0.0632
    Cell Significance Index: -0.8100
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: -0.0639
    Cell Significance Index: -1.3000
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: -0.0642
    Cell Significance Index: -0.8900
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.0670
    Cell Significance Index: -2.4600
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.0673
    Cell Significance Index: -1.7200
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.0673
    Cell Significance Index: -1.8000
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.0696
    Cell Significance Index: -2.0000
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.0706
    Cell Significance Index: -1.7600
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.0707
    Cell Significance Index: -1.5000
  • Cell Name: basal epithelial cell of prostatic duct (CL0002236)
    Fold Change: -0.0721
    Cell Significance Index: -0.6400
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: -0.0759
    Cell Significance Index: -1.0900
  • Cell Name: neuron (CL0000540)
    Fold Change: -0.0770
    Cell Significance Index: -0.7300

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** 1. **Dual Expression**: NODAL is expressed in both the epiblast and the endoderm, suggesting its role in the specification of multiple cell fates during embryonic development. 2. **Left-Right Asymmetry**: NODAL is essential for establishing left-right asymmetry in the lateral mesoderm, which is crucial for the proper development of various organs. 3. **Gastrulation Regulator**: NODAL is involved in regulating gastrulation, a critical process in embryonic development where cells undergo significant rearrangements to form the three primary germ layers. 4. **Stem Cell Maintenance**: NODAL has been shown to maintain stem cell populations in various tissues, including the liver and the hematopoietic system. 5. **Immune System Regulation**: NODAL has been implicated in the regulation of immune responses, particularly in the development and function of dendritic cells and granulocytes. **Pathways and Functions** NODAL signaling involves the activation of the SMAD pathway, which transduces signals from the NODAL receptor to the nucleus, where it regulates gene expression. The NODAL pathway is involved in several key processes, including: 1. **Axial Mesodermal Cell Fate Specification**: NODAL regulates the specification of axial mesodermal cells, which give rise to the somites, a critical structure in the development of the vertebrate body plan. 2. **Brain Development**: NODAL has been implicated in the development of the brain, particularly in the specification of neurons and the formation of the neural tube. 3. **Cell Migration**: NODAL regulates cell migration during gastrulation, which is essential for the proper formation of the three primary germ layers. 4. **Angiogenesis**: NODAL has been shown to promote angiogenesis, the formation of new blood vessels, which is critical for tissue development and growth. 5. **Immune Response Regulation**: NODAL has been implicated in the regulation of immune responses, particularly in the development and function of dendritic cells and granulocytes. **Clinical Significance** Dysregulation of NODAL signaling has been implicated in various human diseases, including: 1. **Left-Right Asymmetry Disorders**: Mutations in the NODAL gene have been associated with left-right asymmetry disorders, such as situs inversus. 2. **Cancer**: NODAL has been implicated in the development and progression of various cancers, including liver and colon cancer. 3. **Immune System Disorders**: NODAL has been implicated in the regulation of immune responses, and dysregulation of NODAL signaling has been associated with autoimmune diseases, such as rheumatoid arthritis. 4. **Reproductive Disorders**: NODAL has been implicated in the regulation of reproduction, and dysregulation of NODAL signaling has been associated with infertility and miscarriage. In conclusion, NODAL is a key signaling molecule that plays a critical role in various developmental and physiological processes. Its dysregulation has been implicated in various human diseases, highlighting the importance of NODAL signaling in maintaining tissue homeostasis and promoting health.

Genular Protein ID: 1045029380

Symbol: NODAL_HUMAN

Name: Nodal homolog

UniProtKB Accession Codes:

Q96S42 Q2M3A5 Q8N4V3

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 5 Ensembl 1 ExpressionAtlas 1 GO 53 Gene3D 1 GeneCards 1 GeneReviews 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 IDEAL 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 3 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 8 OrthoDB 1 PANTHER 2 PDB 1 PDBsum 1 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 2 RefSeq 1 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 neXtProt 1

Citations:

PubMed ID: 15164054

Title: The DNA sequence and comparative analysis of human chromosome 10.

PubMed ID: 15164054

DOI: 10.1038/nature02462

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9354794

Title: X-linked situs abnormalities result from mutations in ZIC3.

PubMed ID: 9354794

DOI: 10.1038/ng1197-305

PubMed ID: 16959974

Title: The consensus coding sequences of human breast and colorectal cancers.

PubMed ID: 16959974

DOI: 10.1126/science.1133427

PubMed ID: 19064609

Title: Identification and functional characterization of NODAL rare variants in heterotaxy and isolated cardiovascular malformations.

PubMed ID: 19064609

DOI: 10.1093/hmg/ddn411

Sequence Information:

  • Length: 347
  • Mass: 39561
  • Checksum: 0D52352B9711650C
  • Sequence:
    • MHAHCLPFLL HAWWALLQAG AATVATALLR TRGQPSSPSP LAYMLSLYRD PLPRADIIRS 
LQAEDVAVDG QNWTFAFDFS FLSQQEDLAW AELRLQLSSP VDLPTEGSLA IEIFHQPKPD 
TEQASDSCLE RFQMDLFTVT LSQVTFSLGS MVLEVTRPLS KWLKHPGALE KQMSRVAGEC 
WPRPPTPPAT NVLLMLYSNL SQEQRQLGGS TLLWEAESSW RAQEGQLSWE WGKRHRRHHL 
PDRSQLCRKV KFQVDFNLIG WGSWIIYPKQ YNAYRCEGEC PNPVGEEFHP TNHAYIQSLL 
KRYQPHRVPS TCCAPVKTKP LSMLYVDNGR VLLDHHKDMI VEECGCL

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.