Details for: TNFRSF6B

Gene ID: 8771

Symbol: TNFRSF6B

Ensembl ID: ENSG00000243509

Description: TNF receptor superfamily member 6b

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 11.3721
    Cell Significance Index: -4.6200
  • Cell Name: prostate gland microvascular endothelial cell (CL2000059)
    Fold Change: 5.3008
    Cell Significance Index: 38.0700
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 4.9542
    Cell Significance Index: -4.7300
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 4.2724
    Cell Significance Index: 497.9000
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 2.6593
    Cell Significance Index: 138.5200
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 1.7235
    Cell Significance Index: 19.5800
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: 1.3208
    Cell Significance Index: 7.9800
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: 0.8155
    Cell Significance Index: 6.6500
  • Cell Name: osteoclast (CL0000092)
    Fold Change: 0.5701
    Cell Significance Index: 5.8200
  • Cell Name: oral mucosa squamous cell (CL1001576)
    Fold Change: 0.4399
    Cell Significance Index: 3.7800
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: 0.3440
    Cell Significance Index: 4.9300
  • Cell Name: fibroblast of lung (CL0002553)
    Fold Change: 0.2701
    Cell Significance Index: 3.2100
  • Cell Name: hematopoietic multipotent progenitor cell (CL0000837)
    Fold Change: 0.1897
    Cell Significance Index: 2.2900
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.1768
    Cell Significance Index: 35.4600
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.1187
    Cell Significance Index: 3.2300
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.0955
    Cell Significance Index: 1.3100
  • Cell Name: primitive red blood cell (CL0002355)
    Fold Change: 0.0945
    Cell Significance Index: 1.0700
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0944
    Cell Significance Index: 33.8600
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: 0.0809
    Cell Significance Index: 2.0200
  • Cell Name: promonocyte (CL0000559)
    Fold Change: 0.0712
    Cell Significance Index: 0.7600
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.0578
    Cell Significance Index: 9.4000
  • Cell Name: vein endothelial cell of respiratory system (CL4033008)
    Fold Change: 0.0512
    Cell Significance Index: 0.3300
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 0.0452
    Cell Significance Index: 2.0000
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.0433
    Cell Significance Index: 5.9400
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: 0.0290
    Cell Significance Index: 1.4700
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 0.0182
    Cell Significance Index: 0.6900
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.0181
    Cell Significance Index: 3.4400
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.0155
    Cell Significance Index: 0.9300
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.0126
    Cell Significance Index: 1.2500
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.0101
    Cell Significance Index: 1.8200
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0013
    Cell Significance Index: -0.1000
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0059
    Cell Significance Index: -0.7200
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0072
    Cell Significance Index: -5.3100
  • Cell Name: blood vessel endothelial cell (CL0000071)
    Fold Change: -0.0083
    Cell Significance Index: -0.0900
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.0133
    Cell Significance Index: -0.3800
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0140
    Cell Significance Index: -7.9100
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0155
    Cell Significance Index: -0.9600
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0166
    Cell Significance Index: -4.7900
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0176
    Cell Significance Index: -2.2500
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.0206
    Cell Significance Index: -0.9400
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.0250
    Cell Significance Index: -0.7200
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: -0.0296
    Cell Significance Index: -2.0500
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0306
    Cell Significance Index: -6.4400
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: -0.0368
    Cell Significance Index: -4.0000
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0416
    Cell Significance Index: -4.7700
  • Cell Name: hepatic stellate cell (CL0000632)
    Fold Change: -0.0427
    Cell Significance Index: -0.4400
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0438
    Cell Significance Index: -2.0600
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0521
    Cell Significance Index: -1.3900
  • Cell Name: myeloid lineage restricted progenitor cell (CL0000839)
    Fold Change: -0.0534
    Cell Significance Index: -0.7500
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0590
    Cell Significance Index: -2.4200
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0627
    Cell Significance Index: -3.5200
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.0684
    Cell Significance Index: -1.7100
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.0810
    Cell Significance Index: -1.7300
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.0982
    Cell Significance Index: -3.4400
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.1029
    Cell Significance Index: -1.5500
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.1032
    Cell Significance Index: -2.2400
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.1194
    Cell Significance Index: -3.9100
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.1195
    Cell Significance Index: -3.8100
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.1245
    Cell Significance Index: -4.3800
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.1264
    Cell Significance Index: -2.7300
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.1279
    Cell Significance Index: -3.1900
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.1305
    Cell Significance Index: -2.6200
  • Cell Name: common dendritic progenitor (CL0001029)
    Fold Change: -0.1305
    Cell Significance Index: -1.3600
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: -0.1309
    Cell Significance Index: -1.8800
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.1322
    Cell Significance Index: -3.1700
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: -0.1329
    Cell Significance Index: -2.7100
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -0.1336
    Cell Significance Index: -2.3100
  • Cell Name: neuron (CL0000540)
    Fold Change: -0.1340
    Cell Significance Index: -1.2700
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.1384
    Cell Significance Index: -2.8700
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.1465
    Cell Significance Index: -3.1100
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.1471
    Cell Significance Index: -3.0700
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: -0.1536
    Cell Significance Index: -1.9700
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.1693
    Cell Significance Index: -2.4300
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.1694
    Cell Significance Index: -3.3500
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: -0.1713
    Cell Significance Index: -2.2400
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: -0.1744
    Cell Significance Index: -2.2100
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.1762
    Cell Significance Index: -4.4900
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: -0.1766
    Cell Significance Index: -2.9100
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.1803
    Cell Significance Index: -4.1700
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: -0.1909
    Cell Significance Index: -1.7200
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: -0.2001
    Cell Significance Index: -1.5300
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: -0.2020
    Cell Significance Index: -3.9800
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.2056
    Cell Significance Index: -4.0200
  • Cell Name: common lymphoid progenitor (CL0000051)
    Fold Change: -0.2088
    Cell Significance Index: -2.1200
  • Cell Name: OFF midget ganglion cell (CL4033047)
    Fold Change: -0.2149
    Cell Significance Index: -2.6800
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.2172
    Cell Significance Index: -5.2600
  • Cell Name: ON midget ganglion cell (CL4033046)
    Fold Change: -0.2203
    Cell Significance Index: -2.7800
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: -0.2223
    Cell Significance Index: -3.6000
  • Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
    Fold Change: -0.2267
    Cell Significance Index: -4.5200
  • Cell Name: erythroblast (CL0000765)
    Fold Change: -0.2357
    Cell Significance Index: -2.8100
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: -0.2403
    Cell Significance Index: -3.2400
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.2473
    Cell Significance Index: -4.5700
  • Cell Name: cytotoxic T cell (CL0000910)
    Fold Change: -0.2525
    Cell Significance Index: -3.6800
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: -0.2539
    Cell Significance Index: -4.3400
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: -0.2612
    Cell Significance Index: -4.4000
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: -0.2716
    Cell Significance Index: -3.2100
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: -0.2751
    Cell Significance Index: -4.1200
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.2819
    Cell Significance Index: -3.3600
  • Cell Name: granulocyte (CL0000094)
    Fold Change: -0.2827
    Cell Significance Index: -3.4100
  • Cell Name: early lymphoid progenitor (CL0000936)
    Fold Change: -0.2832
    Cell Significance Index: -2.8800

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** The TNFRSF6B gene shares structural similarities with other members of the TNF receptor superfamily, including TNFRSF6 (TNF receptor superfamily member 6), which is also known as TRAIL-R2. The protein encoded by TNFRSF6B is a type II transmembrane receptor, consisting of an extracellular domain, a transmembrane domain, and an intracellular domain. The extracellular domain of TNFRSF6B contains two immunoglobulin-like domains, which are essential for ligand binding and receptor activation. The intracellular domain of TNFRSF6B contains a death domain, which is involved in the regulation of apoptosis. **Pathways and Functions** TNFRSF6B is involved in several signaling pathways, including: 1. **Apoptotic process**: TNFRSF6B can modulate the apoptotic process by interacting with its ligands, such as TRAIL (TNF-related apoptosis-inducing ligand). This interaction can lead to the activation of caspases, which are enzymes that execute cell death. 2. **Cytokine signaling in immune system**: TNFRSF6B can interact with cytokines, such as TNF-alpha, to modulate immune responses. This interaction can lead to the activation of immune cells, such as T cells and macrophages. 3. **Negative regulation of apoptotic process**: TNFRSF6B can also modulate the apoptotic process by interacting with other receptors, such as TNFRSF6 (TRAIL-R1). This interaction can lead to the inhibition of apoptosis. **Clinical Significance** Dysregulation of TNFRSF6B has been implicated in various diseases, including: 1. **Cancer**: Overexpression of TNFRSF6B has been observed in several types of cancer, including breast, lung, and colon cancer. This overexpression can lead to the inhibition of apoptosis, allowing cancer cells to survive and proliferate. 2. **Autoimmune diseases**: TNFRSF6B has been implicated in the pathogenesis of autoimmune diseases, such as rheumatoid arthritis and lupus. Dysregulation of TNFRSF6B can lead to the activation of immune cells and the production of autoantibodies. 3. **Inflammatory diseases**: TNFRSF6B has been implicated in the pathogenesis of inflammatory diseases, such as atherosclerosis and inflammatory bowel disease. Dysregulation of TNFRSF6B can lead to the activation of immune cells and the production of pro-inflammatory cytokines. In conclusion, TNFRSF6B is a critical regulator of various cellular processes, including apoptosis, immune responses, and inflammation. Dysregulation of this gene has been implicated in various diseases, highlighting the importance of TNFRSF6B in maintaining tissue homeostasis and preventing disease.

Genular Protein ID: 3350319891

Symbol: TNF6B_HUMAN

Name: Tumor necrosis factor receptor superfamily member 6B

UniProtKB Accession Codes:

O95407

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 DNASU 1 DisGeNET 1 EMBL 9 Ensembl 1 EvolutionaryTrace 1 GO 5 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 8 PDBsum 8 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 1 RefSeq 1 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9872321

Title: Genomic amplification of a decoy receptor for Fas ligand in lung and colon cancer.

PubMed ID: 9872321

DOI: 10.1038/25387

PubMed ID: 10318773

Title: A newly identified member of tumor necrosis factor receptor superfamily (TR6) suppresses LIGHT-mediated apoptosis.

PubMed ID: 10318773

DOI: 10.1074/jbc.274.20.13733

PubMed ID: 10655513

Title: Overexpression of M68/DcR3 in human gastrointestinal tract tumors independent of gene amplification and its location in a four-gene cluster.

PubMed ID: 10655513

DOI: 10.1073/pnas.97.3.1230

PubMed ID: 12975309

Title: The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment.

PubMed ID: 12975309

DOI: 10.1101/gr.1293003

PubMed ID: 11780052

Title: The DNA sequence and comparative analysis of human chromosome 20.

PubMed ID: 11780052

DOI: 10.1038/414865a

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 21300286

Title: Decoy strategies: the structure of TL1A:DcR3 complex.

PubMed ID: 21300286

DOI: 10.1016/j.str.2010.12.004

Sequence Information:

  • Length: 300
  • Mass: 32680
  • Checksum: F90AEE33718449AF
  • Sequence:
    • MRALEGPGLS LLCLVLALPA LLPVPAVRGV AETPTYPWRD AETGERLVCA QCPPGTFVQR 
PCRRDSPTTC GPCPPRHYTQ FWNYLERCRY CNVLCGEREE EARACHATHN RACRCRTGFF 
AHAGFCLEHA SCPPGAGVIA PGTPSQNTQC QPCPPGTFSA SSSSSEQCQP HRNCTALGLA 
LNVPGSSSHD TLCTSCTGFP LSTRVPGAEE CERAVIDFVA FQDISIKRLQ RLLQALEAPE 
GWGPTPRAGR AALQLKLRRR LTELLGAQDG ALLVRLLQAL RVARMPGLER SVRERFLPVH

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.