Details for: ZNF208

Gene ID: 7757

Symbol: ZNF208

Ensembl ID: ENSG00000160321

Description: zinc finger protein 208

Associated with

  • Gene expression (transcription)
    (R-HSA-74160)
  • Generic transcription pathway
    (R-HSA-212436)
  • Rna polymerase ii transcription
    (R-HSA-73857)
  • Dna-binding transcription activator activity, rna polymerase ii-specific
    (GO:0001228)
  • Nucleus
    (GO:0005634)
  • Positive regulation of transcription by rna polymerase ii
    (GO:0045944)
  • Regulation of transcription by rna polymerase ii
    (GO:0006357)
  • Rna polymerase ii cis-regulatory region sequence-specific dna binding
    (GO:0000978)
  • Zinc ion binding
    (GO:0008270)

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: 4.06
    Marker Score: 54015
  • Cell Name: renal principal cell (CL0005009)
    Fold Change: 2.31
    Marker Score: 1778
  • Cell Name: corneal endothelial cell (CL0000132)
    Fold Change: 1.73
    Marker Score: 1006
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.6
    Marker Score: 1160
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: 1.44
    Marker Score: 32221
  • Cell Name: retinal cone cell (CL0000573)
    Fold Change: 1.39
    Marker Score: 3986
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 1.36
    Marker Score: 1357
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 1.28
    Marker Score: 676
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 1.28
    Marker Score: 1721
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: 1.18
    Marker Score: 4178
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 1.14
    Marker Score: 4802
  • Cell Name: primordial germ cell (CL0000670)
    Fold Change: 1.14
    Marker Score: 1424
  • Cell Name: A2 amacrine cell (CL0004219)
    Fold Change: 1.11
    Marker Score: 352
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71812
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48036
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 1
    Marker Score: 4171
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30408
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.97
    Marker Score: 502
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.96
    Marker Score: 455
  • Cell Name: fat cell (CL0000136)
    Fold Change: 0.96
    Marker Score: 537
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2412
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.93
    Marker Score: 5306
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.92
    Marker Score: 368
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2736
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.91
    Marker Score: 616.5
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.89
    Marker Score: 320
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5283
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.86
    Marker Score: 504
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.86
    Marker Score: 356
  • Cell Name: oogonial cell (CL0000024)
    Fold Change: 0.85
    Marker Score: 1218
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.82
    Marker Score: 998
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.82
    Marker Score: 378
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.79
    Marker Score: 1739
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 0.79
    Marker Score: 8153
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.77
    Marker Score: 1254
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.76
    Marker Score: 693
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.75
    Marker Score: 390
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.75
    Marker Score: 572
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.71
    Marker Score: 455
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.7
    Marker Score: 10999
  • Cell Name: renal beta-intercalated cell (CL0002201)
    Fold Change: 0.7
    Marker Score: 222
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.68
    Marker Score: 175
  • Cell Name: podocyte (CL0000653)
    Fold Change: 0.67
    Marker Score: 249
  • Cell Name: ciliated epithelial cell (CL0000067)
    Fold Change: 0.67
    Marker Score: 304
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 0.66
    Marker Score: 226
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: 0.64
    Marker Score: 736
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.6
    Marker Score: 1219
  • Cell Name: adipocyte of epicardial fat of left ventricle (CL1000311)
    Fold Change: 0.57
    Marker Score: 151
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.56
    Marker Score: 444
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.54
    Marker Score: 170
  • Cell Name: cardiac neuron (CL0010022)
    Fold Change: 0.52
    Marker Score: 646
  • Cell Name: oocyte (CL0000023)
    Fold Change: 0.52
    Marker Score: 128
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: 0.51
    Marker Score: 1226
  • Cell Name: male germ cell (CL0000015)
    Fold Change: 0.5
    Marker Score: 143
  • Cell Name: neuron (CL0000540)
    Fold Change: 0.49
    Marker Score: 1986
  • Cell Name: smooth muscle cell of prostate (CL1000487)
    Fold Change: 0.49
    Marker Score: 124
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.48
    Marker Score: 2907
  • Cell Name: interneuron (CL0000099)
    Fold Change: 0.48
    Marker Score: 217
  • Cell Name: parietal epithelial cell (CL1000452)
    Fold Change: 0.47
    Marker Score: 172
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 0.47
    Marker Score: 520
  • Cell Name: kidney interstitial fibroblast (CL1000692)
    Fold Change: 0.47
    Marker Score: 900
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.46
    Marker Score: 192
  • Cell Name: fibroblast of breast (CL4006000)
    Fold Change: 0.46
    Marker Score: 261
  • Cell Name: kidney collecting duct principal cell (CL1001431)
    Fold Change: 0.45
    Marker Score: 1145
  • Cell Name: contractile cell (CL0000183)
    Fold Change: 0.44
    Marker Score: 239
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.44
    Marker Score: 265
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.43
    Marker Score: 127
  • Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
    Fold Change: 0.43
    Marker Score: 462
  • Cell Name: cerebral cortex neuron (CL0010012)
    Fold Change: 0.43
    Marker Score: 1222
  • Cell Name: syncytiotrophoblast cell (CL0000525)
    Fold Change: 0.42
    Marker Score: 348
  • Cell Name: kidney connecting tubule epithelial cell (CL1000768)
    Fold Change: 0.41
    Marker Score: 586
  • Cell Name: neural progenitor cell (CL0011020)
    Fold Change: 0.4
    Marker Score: 1563
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 0.37
    Marker Score: 3214
  • Cell Name: papillary tips cell (CL1000597)
    Fold Change: 0.36
    Marker Score: 72
  • Cell Name: taste receptor cell (CL0000209)
    Fold Change: 0.35
    Marker Score: 301
  • Cell Name: epicardial adipocyte (CL1000309)
    Fold Change: 0.35
    Marker Score: 169
  • Cell Name: alveolar type 2 fibroblast cell (CL4028006)
    Fold Change: 0.34
    Marker Score: 189
  • Cell Name: epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 0.34
    Marker Score: 151
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: 0.32
    Marker Score: 102
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.32
    Marker Score: 152
  • Cell Name: subcutaneous fat cell (CL0002521)
    Fold Change: 0.3
    Marker Score: 111
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 0.3
    Marker Score: 189
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: 0.29
    Marker Score: 93
  • Cell Name: mature astrocyte (CL0002627)
    Fold Change: 0.29
    Marker Score: 189
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: 0.29
    Marker Score: 188
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.28
    Marker Score: 17274
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.28
    Marker Score: 185
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: 0.28
    Marker Score: 296
  • Cell Name: kidney collecting duct intercalated cell (CL1001432)
    Fold Change: 0.28
    Marker Score: 461
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 0.28
    Marker Score: 5916
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 0.28
    Marker Score: 239
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.28
    Marker Score: 73
  • Cell Name: mesothelial cell of epicardium (CL0011019)
    Fold Change: 0.27
    Marker Score: 88
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: 0.27
    Marker Score: 334
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 0.27
    Marker Score: 277
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.26
    Marker Score: 158
  • Cell Name: microglial cell (CL0000129)
    Fold Change: 0.26
    Marker Score: 468
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 0.26
    Marker Score: 59
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: 0.26
    Marker Score: 88
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: 0.25
    Marker Score: 385

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Other Information

**Key Characteristics:** 1. **DNA-binding domain**: ZNF208 possesses a zinc finger domain, which allows it to bind to specific DNA sequences, thereby regulating gene expression. 2. **Transcriptional activation**: ZNF208 acts as a transcriptional activator, promoting the expression of target genes through the recruitment of RNA polymerase II. 3. **Cell-type specificity**: ZNF208 is highly expressed in various cell types, including cardiac muscle cells, renal principal cells, and corneal endothelial cells, suggesting its role in tissue-specific gene regulation. 4. **Regulation of transcription**: ZNF208 modulates the activity of RNA polymerase II, influencing the transcriptional output of target genes. **Pathways and Functions:** 1. **Generic transcription pathway**: ZNF208 is involved in the generic transcription pathway, which is responsible for the expression of thousands of genes in eukaryotic cells. 2. **Regulation of transcription by RNA polymerase II**: ZNF208 regulates the activity of RNA polymerase II, a key enzyme responsible for transcribing genes into RNA. 3. **Positive regulation of transcription by RNA polymerase II**: ZNF208 promotes the expression of target genes through the recruitment of RNA polymerase II. 4. **Zinc ion binding**: ZNF208 binds to zinc ions, which are essential for the proper functioning of its DNA-binding domain. **Clinical Significance:** 1. **Cardiac development and function**: ZNF208 plays a crucial role in cardiac development and function, as it regulates the expression of genes involved in cardiac muscle cell differentiation and contraction. 2. **Renal function**: ZNF208 is involved in the regulation of renal function, influencing the expression of genes involved in sodium and water reabsorption in the kidney. 3. **Corneal endothelial cell function**: ZNF208 regulates the expression of genes involved in corneal endothelial cell function, including ion transport and water balance. 4. **Cancer**: Alterations in ZNF208 expression have been linked to various types of cancer, including breast, lung, and colon cancer, suggesting its potential role as a tumor suppressor gene. 5. **Neurological disorders**: ZNF208 has been implicated in the regulation of gene expression in the brain, and alterations in its expression have been linked to neurological disorders, such as Alzheimer's disease and Parkinson's disease. In conclusion, ZNF208 is a critical regulator of gene expression, transcriptional activation, and cell differentiation. Its dysregulation has been implicated in various diseases, including cancer, cardiovascular disease, and neurological disorders. Further research is necessary to fully elucidate the mechanisms by which ZNF208 regulates gene expression and its clinical significance in human disease.

Genular Protein ID: 817057604

Symbol: ZN208_HUMAN

Name: Zinc finger protein 208

UniProtKB Accession Codes:

O43345

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 1 EPD 1 Ensembl 1 ExpressionAtlas 1 GO 5 Gene3D 2 GeneCards 1 GeneTree 1 Genevisible 1 GenomeRNAi 1 HGNC 1 HPA 1 InParanoid 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRO 1 PROSITE 3 PROSITE-ProRule 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 4 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 1 RefSeq 1 SMART 2 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9724325

Title: Complex beta-satellite repeat structures and the expansion of the zinc finger gene cluster in 19p12.

PubMed ID: 9724325

DOI: 10.1101/gr.8.8.791

PubMed ID: 15057824

Title: The DNA sequence and biology of human chromosome 19.

PubMed ID: 15057824

DOI: 10.1038/nature02399

Sequence Information:

  • Length: 1280
  • Mass: 147487
  • Checksum: 296AEB9EF588A8DB
  • Sequence:
    • MGSLTFRDVA IEFSLEEWQC LDTAQQNLYR NVMLENYRNL VFLGIAAFKP DLIIFLEEGK 
ESWNMKRHEM VEESPVICSH FAQDLWPEQG IEDSFQKVIL RRYEKCGHEN LHLKIGYTNV 
DECKVHKEGY NKLNQSLTTT QSKVFQRGKY ANVFHKCSNS NRHKIRHTGK KHLQCKEYVR 
SFCMLSHLSQ HKRIYTRENS YKCEEGGKAF NWSSTLTYYK SAHTGEKPYR CKECGKAFSK 
FSILTKHKVI HTGEKSYKCE ECGKAFNQSA ILTKHKIIHT GEKPNKCEEC GKAFSKVSTL 
TTHKAIHAGE KPYKCKECGK AFSKVSTLIT HKAIHAGEKP YKCKECGKAF SKFSILTKHK 
VIHTGEKPYK CEECGKAYKW PSTLSYHKKI HTGEKPYKCE ECGKGFSMFS ILTKHEVIHT 
GEKPYKCEEC GKAFNWSSNL MEHKKIHTGE TPYKCEECGK GFSMFSILTK HKVIHNGEKP 
YKCEECDKAT HAGEKPYKCE ECGKAFNWSS NLMEHKRIHT GEKPYKCEEC GKSFSTFSIL 
TKHKVIHTGE KPYKCEECGK AYKWSSTLSY HKKIHTVEKP YKCEECGKAF NQSAILIKHK 
RIHTGEKPYK CEECGKTFSK VSTLTTHKAI HAGEKPYKCK ECGKTFIKVS TLTTHKAIHA 
GEKPYKCKEC GKAFSKFSIL TKHKVIHTGE KPYKCEECGK AFNWSSNLME HKRIHTGEKP 
YKCEECGKSF STFSVLTKHK VIHTGEKPYK CEECGKAYKW SSTLSYHKKI HTVEKPYKCE 
ECGKAFNRSA ILIKHKRIHT DEKPYKCEEC GKTFSKVSTL TTHKAIHAGE KPYKCKECGK 
AFSKFSILTK HKVIHTGEKP YKCEECGKAY KWPSTLSYHK KIHTGEKPYK CEECGKGFSM 
FSILTKHEVI HTGEKPYKCE ECGKAFSWLS VFSKHKKTHA GEKFYKCEAC GKAYKSSSTL 
SYHKKIHTEE KPYKYEECGK GFSTFSILTK HKVIHTGEKP YKCEECGKAF NWSSNLMEHK 
KIHTGETPYK CEECDKAFSW PSSLTEHKAT HAGEKPYKCE ECGKAFSWPS RLTEHKATHA 
GEEPYKCEEC GKAFNWSSNL MEHKRIHTGE KPYKCEECGK SFSTFSILTK HKVIHTGEKP 
YKCEECGKAY KWSSTLSYHK KIHTVEKPYK CEECGKGFVM FSILAKHKVI HTGEKLYKCE 
ECGKAYKWPS TLRYHKKIHT GEKPYKCEEC GKAFSTFSIL TKHKVIHTGE KPYKCEECGK 
AFSWLSVFSK HKKIHTGEKL

Genular Protein ID: 1201939720

Symbol: M0QYK4_HUMAN

Name: N/A

UniProtKB Accession Codes:

M0QYK4

Database IDs:

AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CDD 1 CTD 1 ChiTaRS 1 DNASU 1 EMBL 1 Ensembl 2 ExpressionAtlas 1 GO 1 Gene3D 1 GeneTree 1 GenomeRNAi 1 HGNC 1 InterPro 2 MassIVE 1 NCBI Taxonomy 1 PANTHER 2 PROSITE 2 PeptideAtlas 1 Pfam 1 Proteomes 2 RefSeq 1 SMART 1 SMR 1 SUPFAM 1 UCSC 1 VEuPathDB 1

Citations:

PubMed ID: 15057824

Title: The DNA sequence and biology of human chromosome 19.

PubMed ID: 15057824

DOI: 10.1038/nature02399

Sequence Information:

  • Length: 112
  • Mass: 12842
  • Checksum: C81AD3CF3E360DC0
  • Sequence:
    • MGSLTFRDVA IEFSLEEWQC LDTAQQNLYR NVMLENYRNL VFLGIAAFKP DLIIFLEEGK 
ESWNMKRHEM VEESPGMVGS SGPESSAPYH VHCCPFVLSL RLVSETHQLF LS

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.