Details for: ZNF208

Gene ID: 7757

Symbol: ZNF208

Ensembl ID: ENSG00000160321

Description: zinc finger protein 208

Associated with

  • Gene expression (transcription)
    (R-HSA-74160)
  • Generic transcription pathway
    (R-HSA-212436)
  • Rna polymerase ii transcription
    (R-HSA-73857)
  • Dna-binding transcription activator activity, rna polymerase ii-specific
    (GO:0001228)
  • Nucleus
    (GO:0005634)
  • Positive regulation of transcription by rna polymerase ii
    (GO:0045944)
  • Regulation of transcription by rna polymerase ii
    (GO:0006357)
  • Rna polymerase ii cis-regulatory region sequence-specific dna binding
    (GO:0000978)
  • Zinc ion binding
    (GO:0008270)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 76.6979
    Cell Significance Index: -11.9300
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 44.9450
    Cell Significance Index: -11.4000
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 9.6678
    Cell Significance Index: -11.9200
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 3.1271
    Cell Significance Index: 100.1600
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 3.0233
    Cell Significance Index: -11.9300
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.4739
    Cell Significance Index: 113.1100
  • Cell Name: peg cell (CL4033014)
    Fold Change: 1.1085
    Cell Significance Index: 25.6100
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: 0.9904
    Cell Significance Index: 19.3300
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.8349
    Cell Significance Index: 11.9900
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.7158
    Cell Significance Index: 83.4200
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: 0.6784
    Cell Significance Index: 19.3600
  • Cell Name: germ cell (CL0000586)
    Fold Change: 0.6258
    Cell Significance Index: 4.7300
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 0.3449
    Cell Significance Index: 23.1900
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.3299
    Cell Significance Index: 4.7500
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 0.2988
    Cell Significance Index: 4.7400
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.2449
    Cell Significance Index: 12.7200
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: 0.1788
    Cell Significance Index: 2.6400
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.1369
    Cell Significance Index: 8.2200
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.1266
    Cell Significance Index: 238.4100
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.1220
    Cell Significance Index: 19.8500
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.1074
    Cell Significance Index: 198.1400
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.1064
    Cell Significance Index: 19.1900
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 0.1037
    Cell Significance Index: 0.9600
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: 0.0924
    Cell Significance Index: 57.6700
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.0840
    Cell Significance Index: 16.8500
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: 0.0821
    Cell Significance Index: 4.1500
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0667
    Cell Significance Index: 102.7400
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 0.0647
    Cell Significance Index: 2.4500
  • Cell Name: corneal endothelial cell (CL0000132)
    Fold Change: 0.0624
    Cell Significance Index: 0.9500
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0619
    Cell Significance Index: 39.3200
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.0586
    Cell Significance Index: 26.6100
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0427
    Cell Significance Index: 58.0200
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0384
    Cell Significance Index: 13.7600
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.0368
    Cell Significance Index: 5.0500
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.0354
    Cell Significance Index: 4.5400
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 0.0305
    Cell Significance Index: 3.4900
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.0257
    Cell Significance Index: 3.1600
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 0.0216
    Cell Significance Index: 0.9600
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.0080
    Cell Significance Index: 3.5300
  • Cell Name: adipocyte of breast (CL0002617)
    Fold Change: 0.0075
    Cell Significance Index: 0.0900
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.0037
    Cell Significance Index: 0.1000
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0036
    Cell Significance Index: -2.6900
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0037
    Cell Significance Index: -0.5400
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0037
    Cell Significance Index: -2.7300
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0085
    Cell Significance Index: -4.7900
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0154
    Cell Significance Index: -11.6400
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0177
    Cell Significance Index: -3.7300
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0197
    Cell Significance Index: -3.3700
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0206
    Cell Significance Index: -11.2400
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: -0.0218
    Cell Significance Index: -0.6900
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0234
    Cell Significance Index: -6.7400
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0361
    Cell Significance Index: -7.1700
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0425
    Cell Significance Index: -4.3400
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: -0.0473
    Cell Significance Index: -0.4900
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0523
    Cell Significance Index: -6.1700
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0609
    Cell Significance Index: -4.5400
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.0622
    Cell Significance Index: -1.3300
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.0717
    Cell Significance Index: -8.1800
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.0720
    Cell Significance Index: -3.7800
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0721
    Cell Significance Index: -7.5100
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0752
    Cell Significance Index: -9.7100
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0786
    Cell Significance Index: -4.4100
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.0815
    Cell Significance Index: -1.6900
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.0816
    Cell Significance Index: -1.2300
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.0830
    Cell Significance Index: -2.3900
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.0862
    Cell Significance Index: -2.4700
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: -0.0910
    Cell Significance Index: -6.3000
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0929
    Cell Significance Index: -5.7100
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.0992
    Cell Significance Index: -2.1500
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.1056
    Cell Significance Index: -7.4700
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.1237
    Cell Significance Index: -9.8000
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.1312
    Cell Significance Index: -3.5700
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.1542
    Cell Significance Index: -7.2500
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.1579
    Cell Significance Index: -9.9500
  • Cell Name: taste receptor cell (CL0000209)
    Fold Change: -0.1604
    Cell Significance Index: -1.8700
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.1660
    Cell Significance Index: -4.6400
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.1673
    Cell Significance Index: -7.8000
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: -0.1731
    Cell Significance Index: -2.2200
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.1777
    Cell Significance Index: -3.8900
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: -0.2152
    Cell Significance Index: -3.3300
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.2198
    Cell Significance Index: -5.7800
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.2279
    Cell Significance Index: -7.4600
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.2292
    Cell Significance Index: -7.3000
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.2316
    Cell Significance Index: -8.1200
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.2385
    Cell Significance Index: -6.1300
  • Cell Name: kidney collecting duct principal cell (CL1001431)
    Fold Change: -0.2458
    Cell Significance Index: -2.2400
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: -0.2541
    Cell Significance Index: -2.2900
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.2663
    Cell Significance Index: -7.8500
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.2719
    Cell Significance Index: -9.9800
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.2728
    Cell Significance Index: -9.4800
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: -0.2768
    Cell Significance Index: -3.9400
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.2962
    Cell Significance Index: -6.2000
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: -0.3045
    Cell Significance Index: -4.2100
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.3109
    Cell Significance Index: -7.5300
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.3211
    Cell Significance Index: -8.5900
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.3267
    Cell Significance Index: -8.1500
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: -0.3322
    Cell Significance Index: -4.4800
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.3347
    Cell Significance Index: -11.7600
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.3408
    Cell Significance Index: -10.0100
  • Cell Name: renal principal cell (CL0005009)
    Fold Change: -0.3411
    Cell Significance Index: -3.6100

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **DNA-binding domain**: ZNF208 possesses a zinc finger domain, which allows it to bind to specific DNA sequences, thereby regulating gene expression. 2. **Transcriptional activation**: ZNF208 acts as a transcriptional activator, promoting the expression of target genes through the recruitment of RNA polymerase II. 3. **Cell-type specificity**: ZNF208 is highly expressed in various cell types, including cardiac muscle cells, renal principal cells, and corneal endothelial cells, suggesting its role in tissue-specific gene regulation. 4. **Regulation of transcription**: ZNF208 modulates the activity of RNA polymerase II, influencing the transcriptional output of target genes. **Pathways and Functions:** 1. **Generic transcription pathway**: ZNF208 is involved in the generic transcription pathway, which is responsible for the expression of thousands of genes in eukaryotic cells. 2. **Regulation of transcription by RNA polymerase II**: ZNF208 regulates the activity of RNA polymerase II, a key enzyme responsible for transcribing genes into RNA. 3. **Positive regulation of transcription by RNA polymerase II**: ZNF208 promotes the expression of target genes through the recruitment of RNA polymerase II. 4. **Zinc ion binding**: ZNF208 binds to zinc ions, which are essential for the proper functioning of its DNA-binding domain. **Clinical Significance:** 1. **Cardiac development and function**: ZNF208 plays a crucial role in cardiac development and function, as it regulates the expression of genes involved in cardiac muscle cell differentiation and contraction. 2. **Renal function**: ZNF208 is involved in the regulation of renal function, influencing the expression of genes involved in sodium and water reabsorption in the kidney. 3. **Corneal endothelial cell function**: ZNF208 regulates the expression of genes involved in corneal endothelial cell function, including ion transport and water balance. 4. **Cancer**: Alterations in ZNF208 expression have been linked to various types of cancer, including breast, lung, and colon cancer, suggesting its potential role as a tumor suppressor gene. 5. **Neurological disorders**: ZNF208 has been implicated in the regulation of gene expression in the brain, and alterations in its expression have been linked to neurological disorders, such as Alzheimer's disease and Parkinson's disease. In conclusion, ZNF208 is a critical regulator of gene expression, transcriptional activation, and cell differentiation. Its dysregulation has been implicated in various diseases, including cancer, cardiovascular disease, and neurological disorders. Further research is necessary to fully elucidate the mechanisms by which ZNF208 regulates gene expression and its clinical significance in human disease.

Genular Protein ID: 817057604

Symbol: ZN208_HUMAN

Name: Zinc finger protein 208

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 9724325

Title: Complex beta-satellite repeat structures and the expansion of the zinc finger gene cluster in 19p12.

PubMed ID: 9724325

DOI: 10.1101/gr.8.8.791

PubMed ID: 15057824

Title: The DNA sequence and biology of human chromosome 19.

PubMed ID: 15057824

DOI: 10.1038/nature02399

Sequence Information:

  • Length: 1280
  • Mass: 147487
  • Checksum: 296AEB9EF588A8DB
  • Sequence:
  • MGSLTFRDVA IEFSLEEWQC LDTAQQNLYR NVMLENYRNL VFLGIAAFKP DLIIFLEEGK 
    ESWNMKRHEM VEESPVICSH FAQDLWPEQG IEDSFQKVIL RRYEKCGHEN LHLKIGYTNV 
    DECKVHKEGY NKLNQSLTTT QSKVFQRGKY ANVFHKCSNS NRHKIRHTGK KHLQCKEYVR 
    SFCMLSHLSQ HKRIYTRENS YKCEEGGKAF NWSSTLTYYK SAHTGEKPYR CKECGKAFSK 
    FSILTKHKVI HTGEKSYKCE ECGKAFNQSA ILTKHKIIHT GEKPNKCEEC GKAFSKVSTL 
    TTHKAIHAGE KPYKCKECGK AFSKVSTLIT HKAIHAGEKP YKCKECGKAF SKFSILTKHK 
    VIHTGEKPYK CEECGKAYKW PSTLSYHKKI HTGEKPYKCE ECGKGFSMFS ILTKHEVIHT 
    GEKPYKCEEC GKAFNWSSNL MEHKKIHTGE TPYKCEECGK GFSMFSILTK HKVIHNGEKP 
    YKCEECDKAT HAGEKPYKCE ECGKAFNWSS NLMEHKRIHT GEKPYKCEEC GKSFSTFSIL 
    TKHKVIHTGE KPYKCEECGK AYKWSSTLSY HKKIHTVEKP YKCEECGKAF NQSAILIKHK 
    RIHTGEKPYK CEECGKTFSK VSTLTTHKAI HAGEKPYKCK ECGKTFIKVS TLTTHKAIHA 
    GEKPYKCKEC GKAFSKFSIL TKHKVIHTGE KPYKCEECGK AFNWSSNLME HKRIHTGEKP 
    YKCEECGKSF STFSVLTKHK VIHTGEKPYK CEECGKAYKW SSTLSYHKKI HTVEKPYKCE 
    ECGKAFNRSA ILIKHKRIHT DEKPYKCEEC GKTFSKVSTL TTHKAIHAGE KPYKCKECGK 
    AFSKFSILTK HKVIHTGEKP YKCEECGKAY KWPSTLSYHK KIHTGEKPYK CEECGKGFSM 
    FSILTKHEVI HTGEKPYKCE ECGKAFSWLS VFSKHKKTHA GEKFYKCEAC GKAYKSSSTL 
    SYHKKIHTEE KPYKYEECGK GFSTFSILTK HKVIHTGEKP YKCEECGKAF NWSSNLMEHK 
    KIHTGETPYK CEECDKAFSW PSSLTEHKAT HAGEKPYKCE ECGKAFSWPS RLTEHKATHA 
    GEEPYKCEEC GKAFNWSSNL MEHKRIHTGE KPYKCEECGK SFSTFSILTK HKVIHTGEKP 
    YKCEECGKAY KWSSTLSYHK KIHTVEKPYK CEECGKGFVM FSILAKHKVI HTGEKLYKCE 
    ECGKAYKWPS TLRYHKKIHT GEKPYKCEEC GKAFSTFSIL TKHKVIHTGE KPYKCEECGK 
    AFSWLSVFSK HKKIHTGEKL

Genular Protein ID: 1201939720

Symbol: M0QYK4_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 15057824

Title: The DNA sequence and biology of human chromosome 19.

PubMed ID: 15057824

DOI: 10.1038/nature02399

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

Sequence Information:

  • Length: 112
  • Mass: 12842
  • Checksum: C81AD3CF3E360DC0
  • Sequence:
  • MGSLTFRDVA IEFSLEEWQC LDTAQQNLYR NVMLENYRNL VFLGIAAFKP DLIIFLEEGK 
    ESWNMKRHEM VEESPGMVGS SGPESSAPYH VHCCPFVLSL RLVSETHQLF LS

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.