Details for: PCSK6

Gene ID: 5046

Symbol: PCSK6

Ensembl ID: ENSG00000140479

Description: proprotein convertase subtilisin/kexin type 6

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 132.2445
    Cell Significance Index: -20.5700
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 81.6205
    Cell Significance Index: -20.7000
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 46.6321
    Cell Significance Index: -19.2100
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 19.7854
    Cell Significance Index: -18.8900
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 6.1912
    Cell Significance Index: -13.5500
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 5.2318
    Cell Significance Index: -20.6500
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 4.1556
    Cell Significance Index: 111.3500
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 3.2307
    Cell Significance Index: 469.6200
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 2.8187
    Cell Significance Index: 559.3800
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 2.4279
    Cell Significance Index: 34.8700
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 1.6328
    Cell Significance Index: 61.8300
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: 1.4877
    Cell Significance Index: 10.0800
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.3238
    Cell Significance Index: 101.5900
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 1.3146
    Cell Significance Index: 471.5200
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 1.2827
    Cell Significance Index: 56.7400
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: 1.2435
    Cell Significance Index: 30.3400
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 0.9444
    Cell Significance Index: 23.5500
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.7766
    Cell Significance Index: 43.5800
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.6501
    Cell Significance Index: 123.7200
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: 0.5649
    Cell Significance Index: 3.5100
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.5538
    Cell Significance Index: 25.1000
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: 0.5206
    Cell Significance Index: 10.1600
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 0.3627
    Cell Significance Index: 6.1100
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.3492
    Cell Significance Index: 70.0400
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.3251
    Cell Significance Index: 32.1600
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.2620
    Cell Significance Index: 236.5900
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.1947
    Cell Significance Index: 5.6100
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.1659
    Cell Significance Index: 26.9800
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.1420
    Cell Significance Index: 3.1100
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.1274
    Cell Significance Index: 7.6500
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.1248
    Cell Significance Index: 13.5800
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.1234
    Cell Significance Index: 85.3400
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.0868
    Cell Significance Index: 1.8800
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.0560
    Cell Significance Index: 1.4000
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0446
    Cell Significance Index: 82.2600
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.0312
    Cell Significance Index: 4.2800
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.0178
    Cell Significance Index: 9.7300
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: 0.0088
    Cell Significance Index: 0.1300
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0088
    Cell Significance Index: 0.3100
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.0064
    Cell Significance Index: 1.1500
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0056
    Cell Significance Index: 7.6400
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: 0.0024
    Cell Significance Index: 0.0400
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0006
    Cell Significance Index: 0.8700
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0000
    Cell Significance Index: -0.0100
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0025
    Cell Significance Index: -1.5900
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: -0.0039
    Cell Significance Index: -0.2700
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0108
    Cell Significance Index: -4.9000
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0161
    Cell Significance Index: -0.4300
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0242
    Cell Significance Index: -17.7200
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0293
    Cell Significance Index: -22.1400
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: -0.0304
    Cell Significance Index: -0.2800
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0305
    Cell Significance Index: -22.6200
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0388
    Cell Significance Index: -21.8900
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0399
    Cell Significance Index: -24.8900
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: -0.0417
    Cell Significance Index: -18.4300
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0511
    Cell Significance Index: -6.2800
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0594
    Cell Significance Index: -17.1000
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0595
    Cell Significance Index: -10.1600
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0626
    Cell Significance Index: -7.2900
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: -0.0942
    Cell Significance Index: -1.0100
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: -0.0984
    Cell Significance Index: -1.3800
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.1061
    Cell Significance Index: -5.5100
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.1155
    Cell Significance Index: -2.4000
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1167
    Cell Significance Index: -24.5700
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.1218
    Cell Significance Index: -3.1300
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.1239
    Cell Significance Index: -12.6600
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.1243
    Cell Significance Index: -7.6200
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.1299
    Cell Significance Index: -1.8600
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.1430
    Cell Significance Index: -18.3300
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.1541
    Cell Significance Index: -19.9100
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.1587
    Cell Significance Index: -2.7200
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.1669
    Cell Significance Index: -7.8500
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1791
    Cell Significance Index: -18.6500
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.1834
    Cell Significance Index: -13.6700
  • Cell Name: type II muscle cell (CL0002212)
    Fold Change: -0.1903
    Cell Significance Index: -3.0700
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.1951
    Cell Significance Index: -4.1400
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1951
    Cell Significance Index: -22.3500
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.2042
    Cell Significance Index: -24.0800
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.2089
    Cell Significance Index: -6.6900
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.2423
    Cell Significance Index: -14.8900
  • Cell Name: OFF midget ganglion cell (CL4033047)
    Fold Change: -0.2518
    Cell Significance Index: -3.1400
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.2586
    Cell Significance Index: -17.3900
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.2607
    Cell Significance Index: -18.4400
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.2693
    Cell Significance Index: -21.3300
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.2715
    Cell Significance Index: -9.5100
  • Cell Name: corneal endothelial cell (CL0000132)
    Fold Change: -0.3043
    Cell Significance Index: -4.6300
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.3097
    Cell Significance Index: -16.1300
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.3132
    Cell Significance Index: -6.6700
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.3329
    Cell Significance Index: -20.9800
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.3383
    Cell Significance Index: -17.7600
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -0.3518
    Cell Significance Index: -7.5200
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.3546
    Cell Significance Index: -15.4200
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.3631
    Cell Significance Index: -5.3600
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.3683
    Cell Significance Index: -23.7600
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.3706
    Cell Significance Index: -17.2800
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: -0.3838
    Cell Significance Index: -5.5000
  • Cell Name: ON midget ganglion cell (CL4033046)
    Fold Change: -0.4524
    Cell Significance Index: -5.7100
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.4591
    Cell Significance Index: -23.2000
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.4804
    Cell Significance Index: -9.5000
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: -0.5061
    Cell Significance Index: -6.4900

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** PCSK6 is a member of the proprotein convertase subtilisin/kexin family, which is characterized by their ability to cleave and activate various proteins. PCSK6 is a large protein with a molecular weight of approximately 110 kDa, and its structure consists of a prodomain, a catalytic domain, and a C-terminal tail. The catalytic domain is responsible for its endopeptidase activity, which involves the cleavage of peptide bonds in specific sequences. PCSK6 is also known for its ability to bind to heparin and other glycosaminoglycans, which may play a role in its substrate recognition and activity. **Pathways and Functions:** PCSK6 is involved in several signaling pathways, including: 1. **Regulation of BMP signaling:** PCSK6 has been shown to regulate the BMP signaling pathway, which is crucial for embryonic development, cell growth, and differentiation. 2. **Nerve growth factor production:** PCSK6 is involved in the processing and secretion of nerve growth factor (NGF), which is essential for neuronal growth and development. 3. **Assembly of lipoprotein complexes:** PCSK6 plays a key role in the assembly and remodeling of lipoprotein complexes, which are involved in lipid metabolism and transport. 4. **Keratinization:** PCSK6 has been implicated in the process of keratinization, which is essential for the development of epithelial tissues. 5. **Endopeptidase activity:** PCSK6's endopeptidase activity is involved in the cleavage and activation of various proteins, including peptide hormones and growth factors. **Clinical Significance:** PCSK6's involvement in various cellular processes makes it an attractive target for therapeutic interventions. For example: 1. **Dyslipidemia:** PCSK6's role in lipoprotein assembly and remodeling makes it a potential target for the treatment of dyslipidemia. 2. **Neurological disorders:** PCSK6's involvement in NGF production and processing makes it a potential target for the treatment of neurological disorders, such as Alzheimer's disease and Parkinson's disease. 3. **Cancer:** PCSK6's role in keratinization and endopeptidase activity makes it a potential target for the treatment of certain types of cancer. 4. **Regenerative medicine:** PCSK6's involvement in cellular processes, such as wound healing and tissue repair, makes it a potential target for regenerative medicine applications. In conclusion, PCSK6 is a multifaceted gene that plays a crucial role in various cellular processes. Its involvement in multiple signaling pathways, including the regulation of BMP signaling, nerve growth factor production, and the assembly of lipoprotein complexes, highlights its importance in maintaining cellular homeostasis. Further research is needed to fully elucidate the functions and significance of PCSK6, and to explore its potential as a therapeutic target.

Genular Protein ID: 3759828233

Symbol: PCSK6_HUMAN

Name: Proprotein convertase subtilisin/kexin type 6

UniProtKB Accession Codes:

P29122 Q15099 Q15100 Q9UEG7 Q9UEJ1 Q9UEJ2 Q9UEJ7 Q9UEJ8 Q9UEJ9 Q9Y4G9 Q9Y4H0 Q9Y4H1

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 2 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 4 CDD 2 CTD 1 ChEBI 1 ChEMBL 1 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 EC 1 EMBL 14 Ensembl 4 ExpressionAtlas 1 GO 21 Gene3D 3 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 GuidetoPHARMACOLOGY 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 16 KEGG 1 MANE-Select 1 MEROPS 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 6 PRINTS 1 PRO 1 PROSITE 6 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 4 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 8 Pumba 1 RNAct 1 Reactome 4 RefSeq 7 SIGNOR 1 SMART 2 SMR 1 STRING 1 SUPFAM 4 SignaLink 1 TopDownProteomics 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 1741956

Title: Identification of a second human subtilisin-like protease gene in the fes/fps region of chromosome 15.

PubMed ID: 1741956

DOI: 10.1089/dna.1991.10.757

PubMed ID: 8179631

Title: Identification of novel cDNAs encoding human kexin-like protease, PACE4 isoforms.

PubMed ID: 8179631

DOI: 10.1006/bbrc.1994.1541

PubMed ID: 7980617

Title:

PubMed ID: 7980617

DOI: 10.1006/bbrc.1994.2616

PubMed ID: 9192737

Title: A novel human PACE4 isoform, PACE4E is an active processing protease containing a hydrophobic cluster at the carboxy terminus.

PubMed ID: 9192737

DOI: 10.1093/oxfordjournals.jbchem.a021677

PubMed ID: 9378725

Title: Genomic organization and alternative splicing of human PACE4 (SPC4), kexin-like processing endoprotease.

PubMed ID: 9378725

DOI: 10.1093/oxfordjournals.jbchem.a021772

PubMed ID: 8906861

Title: Functional analysis of human PACE4-A and PACE4-C isoforms: identification of a new PACE4-CS isoform.

PubMed ID: 8906861

DOI: 10.1016/0014-5793(96)01059-9

PubMed ID: 10215603

Title: Endoprotease PACE4 is Ca2+-dependent and temperature-sensitive and can partly rescue the phenotype of a furin-deficient cell strain.

PubMed ID: 10215603

DOI: 10.1042/bj3390639

PubMed ID: 9738469

Title: Biosynthetic processing and quaternary interactions of proprotein convertase SPC4 (PACE4).

PubMed ID: 9738469

DOI: 10.1016/s0014-5793(98)00970-3

PubMed ID: 16433634

Title: A proteomic approach reveals transient association of reticulocalbin-3, a novel member of the CREC family, with the precursor of subtilisin-like proprotein convertase, PACE4.

PubMed ID: 16433634

DOI: 10.1042/bj20051524

Sequence Information:

  • Length: 969
  • Mass: 106420
  • Checksum: A3599CC278D09B05
  • Sequence:
    • MPPRAPPAPG PRPPPRAAAA TDTAAGAGGA GGAGGAGGPG FRPLAPRPWR WLLLLALPAA 
CSAPPPRPVY TNHWAVQVLG GPAEADRVAA AHGYLNLGQI GNLEDYYHFY HSKTFKRSTL 
SSRGPHTFLR MDPQVKWLQQ QEVKRRVKRQ VRSDPQALYF NDPIWSNMWY LHCGDKNSRC 
RSEMNVQAAW KRGYTGKNVV VTILDDGIER NHPDLAPNYD SYASYDVNGN DYDPSPRYDA 
SNENKHGTRC AGEVAASANN SYCIVGIAYN AKIGGIRMLD GDVTDVVEAK SLGIRPNYID 
IYSASWGPDD DGKTVDGPGR LAKQAFEYGI KKGRQGLGSI FVWASGNGGR EGDYCSCDGY 
TNSIYTISVS SATENGYKPW YLEECASTLA TTYSSGAFYE RKIVTTDLRQ RCTDGHTGTS 
VSAPMVAGII ALALEANSQL TWRDVQHLLV KTSRPAHLKA SDWKVNGAGH KVSHFYGFGL 
VDAEALVVEA KKWTAVPSQH MCVAASDKRP RSIPLVQVLR TTALTSACAE HSDQRVVYLE 
HVVVRTSISH PRRGDLQIYL VSPSGTKSQL LAKRLLDLSN EGFTNWEFMT VHCWGEKAEG 
QWTLEIQDLP SQVRNPEKQG KLKEWSLILY GTAEHPYHTF SAHQSRSRML ELSAPELEPP 
KAALSPSQVE VPEDEEDYTA QSTPGSANIL QTSVCHPECG DKGCDGPNAD QCLNCVHFSL 
GSVKTSRKCV SVCPLGYFGD TAARRCRRCH KGCETCSSRA ATQCLSCRRG FYHHQEMNTC 
VTLCPAGFYA DESQKNCLKC HPSCKKCVDE PEKCTVCKEG FSLARGSCIP DCEPGTYFDS 
ELIRCGECHH TCGTCVGPGR EECIHCAKNF HFHDWKCVPA CGEGFYPEEM PGLPHKVCRR 
CDENCLSCAG SSRNCSRCKT GFTQLGTSCI TNHTCSNADE TFCEMVKSNR LCERKLFIQF 
CCRTCLLAG

Genular Protein ID: 4138155508

Symbol: Q59H04_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q59H04

Database IDs:

ARBA 7 AlphaFoldDB 1 BioGRID-ORCS 1 CDD 2 CTD 1 DNASU 1 DisGeNET 1 EMBL 2 GO 6 Gene3D 2 InterPro 16 MEROPS 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PIRSR 1 PRINTS 1 PROSITE 8 PROSITE-ProRule 1 PeptideAtlas 1 Pfam 5 RefSeq 1 RuleBase 1 SAM 1 SMART 2 SUPFAM 4

Sequence Information:

  • Length: 800
  • Mass: 88840
  • Checksum: 71D7EAED4286AC18
  • Sequence:
    • NLGQIGNLED YYHFYHSKTF KRSTLSSRGP HTFLRMDPQV KWLQQQEVKR RVKRQVRSDP 
QALYFNDPIW SNMWYLHCGD KNSRCRSEMN VQAAWKRGYT GKNVVVTILD DGIERNHPDL 
APNYDSYASY DVNGNDYDPS PRYDASNENK HGTRCAGEVA ASANNSYCIV GIAYNAKIGG 
IRMLDGDVTD VVEAKSLGIR PNYIDIYSAS WGPDDDGKTV DGPGRLAKQA FEYGIKKGRQ 
GLGSIFVWAS GNGGREGDYC SCDGYTNSIY TISVSSATEN GYKPWYLEEC ASTLATTYSS 
GAFYERKIVT TDLRQRCTDG HTGTSVSAPM VAGIIALALE AKSIPLVQVL RTTALTSACA 
EHSDQRVVYL EHVVVRTSIS HPRRGDLQIY LVSPSGTKSQ LLAKRLLDLS NEGFTNWEFM 
TVHCWGEKAE GQWTLEIQDL PSQVRNPEKQ GKLKEWSLIL YGTAEHPYHT FSAHQSRSRM 
LELSAPELEP PKAALSPSQV EVPEDEEDYT AQSTPGSANI LQTSVCHPEC GDKGCDGPNA 
DQCLNCVHFS LGSVKTSRKC VSVCPLGYFG DTAARRCRRC HKGCETCSSR AATQCLSCRR 
GFYHHQEMNT CVTLCPAGFY ADESQKNCLK CHPSCKKCVD EPEKCTVCKE GFSLARGSCI 
PDCEPGTYFD SELIRCGECH HTCGTCVGPG REECIHCAKN FHFHDWKCVP ACGEGFYPEE 
MPGLPHKVCR RCDENCLSCA GSSRNCSRCK TGFTQLGTSC ITNHTCSNAD ETFCEMVKSN 
RLCERKLFIQ FCCRTCLLAG

Genular Protein ID: 2707634125

Symbol: H7BXT3_HUMAN

Name: N/A

UniProtKB Accession Codes:

H7BXT3

Database IDs:

ARBA 4 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CDD 1 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 4 Ensembl 2 ExpressionAtlas 1 GO 2 Gene3D 3 GeneTree 1 HGNC 1 InterPro 11 MassIVE 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PIRSR 1 PRINTS 1 PROSITE 6 PROSITE-ProRule 1 PeptideAtlas 2 Pfam 3 Proteomes 2 ProteomicsDB 2 RefSeq 1 RuleBase 1 SAM 1 SMR 1 SUPFAM 3 UCSC 1 VEuPathDB 1

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

PubMed ID: 16572171

Title: Analysis of the DNA sequence and duplication history of human chromosome 15.

PubMed ID: 16572171

DOI: 10.1038/nature04601

Sequence Information:

  • Length: 664
  • Mass: 72999
  • Checksum: 2F88205357942DB8
  • Sequence:
    • MPPRAPPAPG PRPPPRAAAA TDTAAGAGGA GGAGGAGGPG FRPLAPRPWR WLLLLALPAA 
CSAPPPRPVY TNHWAVQVLG GPAEADRVAA AHGYLNLGQI GNLEDYYHFY HSKTFKRSTL 
SSRGPHTFLR MDPQVKWLQQ QEVKRRVKRQ VRSDPQALYF NDPIWSNMWY LHCGDKNSRC 
RSEMNVQAAW KRGYTGKNVV VTILDDGIER NHPDLAPNYD SYASYDVNGN DYDPSPRYDA 
SNENKHGTRC AGEVAASANN SYCIVGIAYN AKIGGIRMLD GDVTDVVEAK SLGIRPNYID 
IYSASWGPDD DGKTVDGPGR LAKQAFEYGI KKGRQGLGSI FVWASGNGGR EGDYCSCDGY 
TNSIYTISVS SATENGYKPW YLEECASTLA TTYSSGAFYE RKIVTTDLRQ RCTDGHTGTS 
VSAPMVAGII ALALEANSQL TWRDVQHLLV KTSRPAHLKA SDWKVNGAGH KVSHFYGFGL 
VDAEALVVEA KKWTAVPSQH MCVAASDKRP RSIPLVQVLR TTALTSACAE HSDQRVVYLE 
HVVVRTSISH PRRGDLQIYL VSPSGTKSQL LAKRLLDLSN EGFTNWEFMT VHCWGEKAEG 
QWTLEIQDLP SQVRNPEKQG DLETPVANQL TTEERFVSTL SILFHWSVYL SWSQYHIVLI 
TVAL

Genular Protein ID: 2332306866

Symbol: A2RQD9_HUMAN

Name: N/A

UniProtKB Accession Codes:

A2RQD9

Database IDs:

ARBA 3 AlphaFoldDB 1 BioGRID-ORCS 1 CDD 1 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 2 GO 6 Gene3D 2 InterPro 9 KEGG 1 MEROPS 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PIRSR 1 PRINTS 1 PROSITE 4 PROSITE-ProRule 1 PeptideAtlas 1 Pfam 4 RefSeq 7 RuleBase 1 SUPFAM 2

Sequence Information:

  • Length: 357
  • Mass: 39414
  • Checksum: 1EACBC356DCAC667
  • Sequence:
    • GGPAEADRVA AAHGYLNLGQ IGNLEDYYHF YHSKTFKRST LSSRGPHTFL RMDPQVKWLQ 
QQEVKRRVKR QVRSDPQALY FNDPIWSNMW YLHCGDKNSR CRSEMNVQAA WKRGYTGKNV 
VVTILDDGIE RNHPDLAPNY DSYASYDVNG NDYDPSPRYD ASNENKHGTR CAGEVAASAN 
NSYCIVGIAY NAKIGGIRML DGDVTDVVEA KSLGIRPNYI DIYSASWGPD DDGKTVDGPG 
RLAKQAFEYG IKKGRQGLGS IFVWASGNGG REGDYCSCDG YTNSIYTISV SSATENGYKP 
WYLEECASTL ATTYSSGAFY ERKIVTTDLR QRCTDGHTGT SVSAPMVAGI IALALEA

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.