Details for: HTR4

Gene ID: 3360

Symbol: HTR4

Ensembl ID: ENSG00000164270

Description: 5-hydroxytryptamine receptor 4

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 13.2863
    Cell Significance Index: -12.6900
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 4.8166
    Cell Significance Index: 213.0500
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 4.0444
    Cell Significance Index: 153.1500
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: 3.1992
    Cell Significance Index: 48.2100
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 2.8321
    Cell Significance Index: 190.4300
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: 2.5581
    Cell Significance Index: 73.0000
  • Cell Name: tuft cell of small intestine (CL0009080)
    Fold Change: 1.9945
    Cell Significance Index: 20.1200
  • Cell Name: pyramidal neuron (CL0000598)
    Fold Change: 1.8214
    Cell Significance Index: 13.9700
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 1.2653
    Cell Significance Index: 36.4600
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 1.2033
    Cell Significance Index: 30.0800
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.9692
    Cell Significance Index: 95.8800
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: 0.9344
    Cell Significance Index: 12.6000
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.9231
    Cell Significance Index: 150.1300
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: 0.7902
    Cell Significance Index: 19.1400
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.7494
    Cell Significance Index: 33.9700
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.6890
    Cell Significance Index: 622.0900
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.6656
    Cell Significance Index: 14.4200
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.6583
    Cell Significance Index: 39.5200
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.6270
    Cell Significance Index: 125.7700
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.5998
    Cell Significance Index: 65.2400
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.5858
    Cell Significance Index: 12.4800
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.5086
    Cell Significance Index: 10.5500
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.4458
    Cell Significance Index: 88.4800
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 0.4452
    Cell Significance Index: 7.6100
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.2920
    Cell Significance Index: 20.1900
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 0.2898
    Cell Significance Index: 6.1500
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.2502
    Cell Significance Index: 19.2000
  • Cell Name: L2/3 intratelencephalic projecting glutamatergic neuron (CL4030059)
    Fold Change: 0.2461
    Cell Significance Index: 3.2800
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.2202
    Cell Significance Index: 41.9000
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.1895
    Cell Significance Index: 131.0600
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 0.1680
    Cell Significance Index: 4.1900
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.0641
    Cell Significance Index: 0.9200
  • Cell Name: cerebral cortex neuron (CL0010012)
    Fold Change: 0.0221
    Cell Significance Index: 0.2100
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: 0.0184
    Cell Significance Index: 0.3700
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0153
    Cell Significance Index: 5.4700
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0077
    Cell Significance Index: 14.2200
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0057
    Cell Significance Index: 0.2000
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0057
    Cell Significance Index: 8.8200
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0017
    Cell Significance Index: 2.2500
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0025
    Cell Significance Index: -4.7000
  • Cell Name: hippocampal interneuron (CL1001569)
    Fold Change: -0.0062
    Cell Significance Index: -0.0800
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.0090
    Cell Significance Index: -0.3900
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.0103
    Cell Significance Index: -0.3300
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0179
    Cell Significance Index: -13.2600
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0187
    Cell Significance Index: -11.8800
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0215
    Cell Significance Index: -9.7400
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.0216
    Cell Significance Index: -0.3100
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0221
    Cell Significance Index: -13.8000
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0235
    Cell Significance Index: -13.2500
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0338
    Cell Significance Index: -9.7200
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.0395
    Cell Significance Index: -2.4200
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0526
    Cell Significance Index: -8.9900
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0554
    Cell Significance Index: -9.9800
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0614
    Cell Significance Index: -8.9200
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0636
    Cell Significance Index: -13.4000
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.0661
    Cell Significance Index: -1.6500
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.0731
    Cell Significance Index: -4.6100
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0813
    Cell Significance Index: -2.5900
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.0855
    Cell Significance Index: -2.8000
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0926
    Cell Significance Index: -11.3900
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0980
    Cell Significance Index: -2.7400
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.0986
    Cell Significance Index: -1.6900
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.1155
    Cell Significance Index: -11.8000
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1177
    Cell Significance Index: -13.4800
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.1182
    Cell Significance Index: -4.1400
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1184
    Cell Significance Index: -12.3300
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.1199
    Cell Significance Index: -2.9900
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.1221
    Cell Significance Index: -1.3300
  • Cell Name: L6 intratelencephalic projecting glutamatergic neuron of the primary motor cortex (CL4023050)
    Fold Change: -0.1439
    Cell Significance Index: -1.9200
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.1463
    Cell Significance Index: -2.1600
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: -0.1546
    Cell Significance Index: -2.1200
  • Cell Name: neuron (CL0000540)
    Fold Change: -0.1667
    Cell Significance Index: -1.5800
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.1715
    Cell Significance Index: -10.5400
  • Cell Name: L5 intratelencephalic projecting glutamatergic neuron (CL4030064)
    Fold Change: -0.1779
    Cell Significance Index: -1.9200
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: -0.1825
    Cell Significance Index: -2.3400
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.1928
    Cell Significance Index: -8.9900
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: -0.1957
    Cell Significance Index: -2.4700
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.2001
    Cell Significance Index: -11.2300
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.2095
    Cell Significance Index: -11.0000
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.2118
    Cell Significance Index: -5.0800
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: -0.2195
    Cell Significance Index: -2.8400
  • Cell Name: mesothelial cell of epicardium (CL0011019)
    Fold Change: -0.2220
    Cell Significance Index: -1.9200
  • Cell Name: neural cell (CL0002319)
    Fold Change: -0.2289
    Cell Significance Index: -2.6700
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.2411
    Cell Significance Index: -12.5600
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.2435
    Cell Significance Index: -4.8200
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.2435
    Cell Significance Index: -8.9400
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.2642
    Cell Significance Index: -6.7900
  • Cell Name: retinal blood vessel endothelial cell (CL0002585)
    Fold Change: -0.2872
    Cell Significance Index: -3.7100
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.2885
    Cell Significance Index: -13.5600
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: -0.3332
    Cell Significance Index: -8.1300
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.3332
    Cell Significance Index: -9.0700
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.3410
    Cell Significance Index: -17.2300
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: -0.3475
    Cell Significance Index: -10.9900
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.3520
    Cell Significance Index: -7.6100
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: -0.3707
    Cell Significance Index: -3.8400
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.3863
    Cell Significance Index: -7.5400
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: -0.3989
    Cell Significance Index: -4.7700
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: -0.4095
    Cell Significance Index: -5.8300
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.4125
    Cell Significance Index: -8.6100
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: -0.4182
    Cell Significance Index: -8.5100

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** HTR4 is a member of the class A/1 rhodopsin-like receptor family, characterized by its seven transmembrane alpha-helices and the presence of a conserved N-terminal extracellular domain. The receptor is activated by serotonin, which binds to the extracellular ligand-binding domain, triggering a conformational change that activates the G-protein coupled signaling pathway. HTR4 is widely expressed in various tissues, including the brain, gut, and cardiovascular system, with a high density of expression in the gastrointestinal tract and the retina. **Pathways and Functions** The HTR4 receptor is involved in several signaling pathways, including: 1. **G-protein coupled signaling pathway**: The activation of HTR4 triggers the activation of G-proteins, which in turn activate downstream effectors, such as adenylyl cyclase, phospholipase C, and protein kinase C. 2. **Cyclic nucleotide second messenger pathway**: HTR4 activation also activates the cyclic nucleotide second messenger pathway, leading to the production of cAMP and cGMP. 3. **Neurotransmitter receptor activity**: HTR4 is a neurotransmitter receptor, and its activation regulates the release of neurotransmitters, such as serotonin and dopamine. 4. **Regulation of appetite**: HTR4 is involved in the regulation of appetite and satiety, with its activation promoting food intake and satiety. 5. **Gastrointestinal motility**: HTR4 is also involved in regulating gastrointestinal motility, with its activation promoting the contraction of smooth muscle cells in the gut. **Clinical Significance** HTR4 has been implicated in various diseases and disorders, including: 1. **Gastrointestinal disorders**: HTR4 has been shown to play a role in the pathogenesis of gastrointestinal disorders, such as irritable bowel syndrome (IBS) and inflammatory bowel disease (IBD). 2. **Neurological disorders**: HTR4 has been implicated in the pathogenesis of neurological disorders, such as depression, anxiety, and Parkinson's disease. 3. **Cardiovascular disease**: HTR4 has been shown to play a role in the regulation of cardiovascular function, and its dysregulation has been implicated in the pathogenesis of cardiovascular disease. 4. **Cancer**: HTR4 has been shown to play a role in the regulation of cell growth and survival, and its dysregulation has been implicated in the pathogenesis of certain types of cancer. In conclusion, the HTR4 gene plays a crucial role in various physiological and pathological processes, and its dysregulation has been implicated in the pathogenesis of various diseases and disorders. Further research is needed to fully understand the role of HTR4 in human health and disease.

Genular Protein ID: 2130399556

Symbol: 5HT4R_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q13639 C4WYH4 Q546Q1 Q684M0 Q712M9 Q96KH9 Q96KI0 Q9H199 Q9NY73 Q9UBM6 Q9UBT4 Q9UE22 Q9UE23 Q9UQR6

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 6 CDD 1 CTD 1 ChEBI 2 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 21 DrugCentral 1 EMBL 28 Ensembl 7 ExpressionAtlas 1 GO 17 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 GuidetoPHARMACOLOGY 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 4 PDBsum 4 PIR 1 PRINTS 2 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 RNAct 1 Reactome 2 RefSeq 6 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TCDB 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 9603189

Title: Cloning, expression, and pharmacology of four human 5-hydroxytryptamine 4 receptor isoforms produced by alternative splicing in the carboxyl terminus.

PubMed ID: 9603189

DOI: 10.1046/j.1471-4159.1998.70062252.x

PubMed ID: 9351641

Title: Cloning and expression of human 5-HT4S receptors. Effect of receptor density on their coupling to adenylyl cyclase.

PubMed ID: 9351641

DOI: 10.1097/00001756-199710200-00002

PubMed ID: 10220570

Title: Novel brain-specific 5-HT4 receptor splice variants show marked constitutive activity: role of the C-terminal intracellular domain.

PubMed ID: 10220570

PubMed ID: 11750916

Title: Cloning and characterization of a novel human 5-HT4 receptor variant that lacks the alternatively spliced carboxy terminal exon. RT-PCR distribution in human brain and periphery of multiple 5-HT4 receptor variants.

PubMed ID: 11750916

DOI: 10.1016/s0028-3908(01)00154-x

PubMed ID: 15118808

Title: Cloning, pharmacological characterisation and tissue distribution of a novel 5-HT4 receptor splice variant, 5-HT4(i).

PubMed ID: 15118808

DOI: 10.1007/s00210-004-0919-4

PubMed ID: 15372022

Title: The DNA sequence and comparative analysis of human chromosome 5.

PubMed ID: 15372022

DOI: 10.1038/nature02919

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 10646498

Title: Structure of the human serotonin 5-HT4 receptor gene and cloning of a novel 5-HT4 splice variant.

PubMed ID: 10646498

DOI: 10.1046/j.1471-4159.2000.740478.x

PubMed ID: 7656980

Title: Expression of serotonin receptor mRNAs in blood vessels.

PubMed ID: 7656980

DOI: 10.1016/0014-5793(95)00828-w

PubMed ID: 10821780

Title: Exploration of the ligand binding site of the human 5-HT(4) receptor by site-directed mutagenesis and molecular modeling.

PubMed ID: 10821780

DOI: 10.1038/sj.bjp.0703356

PubMed ID: 16102731

Title: A high-affinity monoclonal antibody with functional activity against the 5-hydroxytryptaminergic (5-HT4) receptor.

PubMed ID: 16102731

DOI: 10.1016/j.bcp.2005.07.005

PubMed ID: 19661922

Title: Beta-arrestin1 phosphorylation by GRK5 regulates G protein-independent 5-HT4 receptor signalling.

PubMed ID: 19661922

DOI: 10.1038/emboj.2009.215

PubMed ID: 35714614

Title: GPCRs steer Gi and Gs selectivity via TM5-TM6 switches as revealed by structures of serotonin receptors.

PubMed ID: 35714614

DOI: 10.1016/j.molcel.2022.05.031

PubMed ID: 22197934

Title: Mutations in the colony stimulating factor 1 receptor (CSF1R) gene cause hereditary diffuse leukoencephalopathy with spheroids.

PubMed ID: 22197934

DOI: 10.1038/ng.1027

Sequence Information:

  • Length: 388
  • Mass: 43761
  • Checksum: 7FCFEC60E7BDF560
  • Sequence:
    • MDKLDANVSS EEGFGSVEKV VLLTFLSTVI LMAILGNLLV MVAVCWDRQL RKIKTNYFIV 
SLAFADLLVS VLVMPFGAIE LVQDIWIYGE VFCLVRTSLD VLLTTASIFH LCCISLDRYY 
AICCQPLVYR NKMTPLRIAL MLGGCWVIPT FISFLPIMQG WNNIGIIDLI EKRKFNQNSN 
STYCVFMVNK PYAITCSVVA FYIPFLLMVL AYYRIYVTAK EHAHQIQMLQ RAGASSESRP 
QSADQHSTHR MRTETKAAKT LCIIMGCFCL CWAPFFVTNI VDPFIDYTVP GQVWTAFLWL 
GYINSGLNPF LYAFLNKSFR RAFLIILCCD DERYRRPSIL GQTVPCSTTT INGSTHVLRD 
AVECGGQWES QCHPPATSPL VAAQPSDT

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.