Details for: HTR4

Gene ID: 3360

Symbol: HTR4

Ensembl ID: ENSG00000164270

Description: 5-hydroxytryptamine receptor 4

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: retinal bipolar neuron (CL0000748)
    Fold Change: 3.38
    Marker Score: 28603.5
  • Cell Name: Mueller cell (CL0000636)
    Fold Change: 3.2
    Marker Score: 4443
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 2.18
    Marker Score: 1240
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: 2.15
    Marker Score: 7631
  • Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
    Fold Change: 2.15
    Marker Score: 4441.5
  • Cell Name: cerebral cortex neuron (CL0010012)
    Fold Change: 1.76
    Marker Score: 5018
  • Cell Name: pyramidal neuron (CL0000598)
    Fold Change: 1.72
    Marker Score: 2886
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 1.7
    Marker Score: 3230
  • Cell Name: interneuron (CL0000099)
    Fold Change: 1.69
    Marker Score: 772.5
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: 1.62
    Marker Score: 2238.5
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 1.6
    Marker Score: 2464
  • Cell Name: ON-bipolar cell (CL0000749)
    Fold Change: 1.49
    Marker Score: 4353
  • Cell Name: mural cell (CL0008034)
    Fold Change: 1.48
    Marker Score: 169953
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 1.48
    Marker Score: 780
  • Cell Name: retina horizontal cell (CL0000745)
    Fold Change: 1.48
    Marker Score: 1419
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 1.45
    Marker Score: 2954
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 1.39
    Marker Score: 51241
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.24
    Marker Score: 76154
  • Cell Name: epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 1.19
    Marker Score: 535
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.17
    Marker Score: 18348
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 1.04
    Marker Score: 433.5
  • Cell Name: retinal cone cell (CL0000573)
    Fold Change: 1.01
    Marker Score: 2910
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71819.5
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48043
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.99
    Marker Score: 510
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: 0.99
    Marker Score: 4116
  • Cell Name: OFF-bipolar cell (CL0000750)
    Fold Change: 0.98
    Marker Score: 2920
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30408
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.98
    Marker Score: 463
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.97
    Marker Score: 5839
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2413
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.94
    Marker Score: 375
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.92
    Marker Score: 5275
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.92
    Marker Score: 2741
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.91
    Marker Score: 326
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.88
    Marker Score: 531
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5295
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 0.86
    Marker Score: 32588
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 0.82
    Marker Score: 7046
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.78
    Marker Score: 3276.5
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1263
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.77
    Marker Score: 397
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.76
    Marker Score: 693
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.72
    Marker Score: 463
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 0.69
    Marker Score: 7076
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: 0.67
    Marker Score: 14938
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.57
    Marker Score: 270
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.57
    Marker Score: 451
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.56
    Marker Score: 1316
  • Cell Name: neuron (CL0000540)
    Fold Change: 0.53
    Marker Score: 2149
  • Cell Name: intestinal crypt stem cell (CL0002250)
    Fold Change: 0.51
    Marker Score: 191
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 0.49
    Marker Score: 4644
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.48
    Marker Score: 212
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.48
    Marker Score: 315
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 0.47
    Marker Score: 4457
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.47
    Marker Score: 151
  • Cell Name: epicardial adipocyte (CL1000309)
    Fold Change: 0.44
    Marker Score: 215
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.4
    Marker Score: 125
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: 0.39
    Marker Score: 486
  • Cell Name: paneth cell (CL0000510)
    Fold Change: 0.37
    Marker Score: 258.5
  • Cell Name: kidney collecting duct intercalated cell (CL1001432)
    Fold Change: 0.36
    Marker Score: 598
  • Cell Name: cardiac neuron (CL0010022)
    Fold Change: 0.34
    Marker Score: 428
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.34
    Marker Score: 230
  • Cell Name: fat cell (CL0000136)
    Fold Change: 0.3
    Marker Score: 169
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: 0.3
    Marker Score: 78
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.29
    Marker Score: 285
  • Cell Name: neuroendocrine cell (CL0000165)
    Fold Change: 0.27
    Marker Score: 104
  • Cell Name: parietal epithelial cell (CL1000452)
    Fold Change: 0.26
    Marker Score: 95
  • Cell Name: interstitial cell of Cajal (CL0002088)
    Fold Change: 0.25
    Marker Score: 88
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 0.25
    Marker Score: 5036
  • Cell Name: enterocyte of colon (CL1000347)
    Fold Change: 0.25
    Marker Score: 386
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.24
    Marker Score: 141
  • Cell Name: microglial cell (CL0000129)
    Fold Change: 0.23
    Marker Score: 421
  • Cell Name: ciliated epithelial cell (CL0000067)
    Fold Change: 0.23
    Marker Score: 105
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.23
    Marker Score: 65
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.22
    Marker Score: 75
  • Cell Name: Kupffer cell (CL0000091)
    Fold Change: 0.22
    Marker Score: 220
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.22
    Marker Score: 294
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.22
    Marker Score: 69
  • Cell Name: monocyte (CL0000576)
    Fold Change: 0.22
    Marker Score: 282
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 0.21
    Marker Score: 188
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.21
    Marker Score: 124
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.2
    Marker Score: 82
  • Cell Name: pericyte (CL0000669)
    Fold Change: 0.2
    Marker Score: 114
  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.19
    Marker Score: 112
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 0.19
    Marker Score: 166
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: 0.19
    Marker Score: 1430
  • Cell Name: stellate neuron (CL0000122)
    Fold Change: 0.19
    Marker Score: 997
  • Cell Name: macroglial cell (CL0000126)
    Fold Change: 0.18
    Marker Score: 422
  • Cell Name: hepatic stellate cell (CL0000632)
    Fold Change: 0.18
    Marker Score: 69
  • Cell Name: neural cell (CL0002319)
    Fold Change: 0.18
    Marker Score: 87.5
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.18
    Marker Score: 219
  • Cell Name: stromal cell (CL0000499)
    Fold Change: 0.18
    Marker Score: 212
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: 0.18
    Marker Score: 431
  • Cell Name: endothelial cell of artery (CL1000413)
    Fold Change: 0.18
    Marker Score: 73
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: 0.17
    Marker Score: 60
  • Cell Name: melanocyte (CL0000148)
    Fold Change: 0.17
    Marker Score: 69
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: 0.17
    Marker Score: 93
  • Cell Name: stem cell (CL0000034)
    Fold Change: 0.16
    Marker Score: 380
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: 0.16
    Marker Score: 1597

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Other Information

**Key characteristics:** * HTR4 is a G protein-coupled receptor that is expressed in a variety of cell types. * It is a ligand-gated channel that is sensitive to 5-hydroxytryptamine (5HT). * Activation of HTR4 by 5HT induces a variety of cellular responses, including the inhibition of adenylate cyclase and the activation of phospholipase C. * HTR4 is also involved in regulating the release of neurotransmitters, such as serotonin, from presynaptic terminals. **Pathways and functions:** * HTR4 is involved in maintaining gastrointestinal epithelium by regulating the secretion of mucus. * It is also involved in regulating appetite by modulating the release of neurotransmitters, such as serotonin, from presynaptic terminals. * HTR4 is also involved in the regulation of inflammation by modulating the release of inflammatory cytokines. **Clinical significance:** * Mutations in the HTR4 gene have been linked to a number of neurological disorders, including schizophrenia, depression, and anxiety. * These mutations can disrupt the normal function of HTR4, leading to the development of these psychiatric conditions. * Therefore, HTR4 is a promising target for the treatment of psychiatric disorders. **Additional notes:** * HTR4 is a relatively new receptor, and there is still a lot that is unknown about its function. * The exact mechanisms by which HTR4 exerts its effects are still being investigated. * There are a number of drugs that target HTR4, and these drugs are being evaluated in clinical trials for the treatment of psychiatric disorders.

Genular Protein ID: 2130399556

Symbol: 5HT4R_HUMAN

Name: 5-hydroxytryptamine receptor 4

UniProtKB Accession Codes:

Q13639 C4WYH4 Q546Q1 Q684M0 Q712M9 Q96KH9 Q96KI0 Q9H199 Q9NY73 Q9UBM6 Q9UBT4 Q9UE22 Q9UE23 Q9UQR6

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 6 CDD 1 CTD 1 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 21 DrugCentral 1 EMBL 28 Ensembl 7 ExpressionAtlas 1 GO 16 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 GuidetoPHARMACOLOGY 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 6 PDBsum 4 PIR 1 PRINTS 2 PRO 1 PROSITE 2 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 RNAct 1 Reactome 2 RefSeq 6 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TCDB 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 9603189

Title: Cloning, expression, and pharmacology of four human 5-hydroxytryptamine 4 receptor isoforms produced by alternative splicing in the carboxyl terminus.

PubMed ID: 9603189

DOI: 10.1046/j.1471-4159.1998.70062252.x

PubMed ID: 9351641

Title: Cloning and expression of human 5-HT4S receptors. Effect of receptor density on their coupling to adenylyl cyclase.

PubMed ID: 9351641

DOI: 10.1097/00001756-199710200-00002

PubMed ID: 10220570

Title: Novel brain-specific 5-HT4 receptor splice variants show marked constitutive activity: role of the C-terminal intracellular domain.

PubMed ID: 10220570

PubMed ID: 11750916

Title: Cloning and characterization of a novel human 5-HT4 receptor variant that lacks the alternatively spliced carboxy terminal exon. RT-PCR distribution in human brain and periphery of multiple 5-HT4 receptor variants.

PubMed ID: 11750916

DOI: 10.1016/s0028-3908(01)00154-x

PubMed ID: 15118808

Title: Cloning, pharmacological characterisation and tissue distribution of a novel 5-HT4 receptor splice variant, 5-HT4(i).

PubMed ID: 15118808

DOI: 10.1007/s00210-004-0919-4

PubMed ID: 15372022

Title: The DNA sequence and comparative analysis of human chromosome 5.

PubMed ID: 15372022

DOI: 10.1038/nature02919

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 10646498

Title: Structure of the human serotonin 5-HT4 receptor gene and cloning of a novel 5-HT4 splice variant.

PubMed ID: 10646498

DOI: 10.1046/j.1471-4159.2000.740478.x

PubMed ID: 7656980

Title: Expression of serotonin receptor mRNAs in blood vessels.

PubMed ID: 7656980

DOI: 10.1016/0014-5793(95)00828-w

PubMed ID: 19661922

Title: Beta-arrestin1 phosphorylation by GRK5 regulates G protein-independent 5-HT4 receptor signalling.

PubMed ID: 19661922

DOI: 10.1038/emboj.2009.215

PubMed ID: 22197934

Title: Mutations in the colony stimulating factor 1 receptor (CSF1R) gene cause hereditary diffuse leukoencephalopathy with spheroids.

PubMed ID: 22197934

DOI: 10.1038/ng.1027

Sequence Information:

  • Length: 388
  • Mass: 43761
  • Checksum: 7FCFEC60E7BDF560
  • Sequence:
    • MDKLDANVSS EEGFGSVEKV VLLTFLSTVI LMAILGNLLV MVAVCWDRQL RKIKTNYFIV 
SLAFADLLVS VLVMPFGAIE LVQDIWIYGE VFCLVRTSLD VLLTTASIFH LCCISLDRYY 
AICCQPLVYR NKMTPLRIAL MLGGCWVIPT FISFLPIMQG WNNIGIIDLI EKRKFNQNSN 
STYCVFMVNK PYAITCSVVA FYIPFLLMVL AYYRIYVTAK EHAHQIQMLQ RAGASSESRP 
QSADQHSTHR MRTETKAAKT LCIIMGCFCL CWAPFFVTNI VDPFIDYTVP GQVWTAFLWL 
GYINSGLNPF LYAFLNKSFR RAFLIILCCD DERYRRPSIL GQTVPCSTTT INGSTHVLRD 
AVECGGQWES QCHPPATSPL VAAQPSDT

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.