Details for: UFM1

Gene ID: 51569

Symbol: UFM1

Ensembl ID: ENSG00000120686

Description: ubiquitin fold modifier 1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 321.7071
    Cell Significance Index: -50.0400
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 192.8495
    Cell Significance Index: -48.9200
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 140.6004
    Cell Significance Index: -57.9200
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 117.1941
    Cell Significance Index: -55.3300
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 106.2822
    Cell Significance Index: -54.6700
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 82.7991
    Cell Significance Index: -55.5600
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 44.2595
    Cell Significance Index: -54.5700
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 18.5788
    Cell Significance Index: -49.7700
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 14.1661
    Cell Significance Index: -55.9000
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 12.9711
    Cell Significance Index: -39.8400
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 8.4804
    Cell Significance Index: -18.5600
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 4.7271
    Cell Significance Index: 326.9100
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 2.9992
    Cell Significance Index: 85.9800
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 2.3536
    Cell Significance Index: 141.3000
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 2.0790
    Cell Significance Index: 56.5900
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 1.6616
    Cell Significance Index: 77.4700
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 1.5767
    Cell Significance Index: 74.1100
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 1.5406
    Cell Significance Index: 21.0200
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 1.4882
    Cell Significance Index: 204.3700
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 1.3490
    Cell Significance Index: 736.7200
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 1.2735
    Cell Significance Index: 156.5900
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 1.1977
    Cell Significance Index: 31.9800
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 1.1466
    Cell Significance Index: 206.7000
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 1.0227
    Cell Significance Index: 111.2400
  • Cell Name: peg cell (CL4033014)
    Fold Change: 0.9657
    Cell Significance Index: 22.3100
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.9324
    Cell Significance Index: 69.4900
  • Cell Name: luminal hormone-sensing cell of mammary gland (CL4033058)
    Fold Change: 0.8945
    Cell Significance Index: 5.5100
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.8546
    Cell Significance Index: 171.4400
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.8049
    Cell Significance Index: 51.9300
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.8024
    Cell Significance Index: 354.7700
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.7344
    Cell Significance Index: 94.8800
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.7323
    Cell Significance Index: 38.0400
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: 0.6920
    Cell Significance Index: 10.5100
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.6806
    Cell Significance Index: 110.6900
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.6295
    Cell Significance Index: 44.5200
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.5951
    Cell Significance Index: 70.1800
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.5435
    Cell Significance Index: 15.6600
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.5336
    Cell Significance Index: 91.1200
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.4866
    Cell Significance Index: 48.1400
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.4859
    Cell Significance Index: 96.4300
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.4851
    Cell Significance Index: 174.0100
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: 0.4115
    Cell Significance Index: 256.9700
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 0.3793
    Cell Significance Index: 11.1400
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.3303
    Cell Significance Index: 42.3400
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.2622
    Cell Significance Index: 49.8900
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 0.2589
    Cell Significance Index: 5.4200
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 0.2170
    Cell Significance Index: 7.5400
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.1819
    Cell Significance Index: 11.1800
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.0980
    Cell Significance Index: 88.4500
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0677
    Cell Significance Index: 2.3800
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.0571
    Cell Significance Index: 43.2100
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0328
    Cell Significance Index: 61.7900
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0101
    Cell Significance Index: 6.4200
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.0011
    Cell Significance Index: -0.0300
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0071
    Cell Significance Index: -13.1100
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0112
    Cell Significance Index: -17.2100
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0179
    Cell Significance Index: -0.3000
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0217
    Cell Significance Index: -16.0900
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0267
    Cell Significance Index: -19.5900
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.0282
    Cell Significance Index: -0.6000
  • Cell Name: thyroid follicular cell (CL0002258)
    Fold Change: -0.0301
    Cell Significance Index: -0.3200
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0361
    Cell Significance Index: -2.7700
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0371
    Cell Significance Index: -50.3800
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0402
    Cell Significance Index: -18.2400
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0533
    Cell Significance Index: -5.4400
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.0552
    Cell Significance Index: -1.0200
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.0634
    Cell Significance Index: -3.3300
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0720
    Cell Significance Index: -40.6100
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: -0.0961
    Cell Significance Index: -0.8800
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.1229
    Cell Significance Index: -6.9000
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1250
    Cell Significance Index: -26.3300
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.1352
    Cell Significance Index: -38.9000
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -0.1472
    Cell Significance Index: -2.2100
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.1661
    Cell Significance Index: -10.4700
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.1689
    Cell Significance Index: -4.7200
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.1814
    Cell Significance Index: -20.7100
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.1998
    Cell Significance Index: -29.0400
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -0.2069
    Cell Significance Index: -1.2500
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.2413
    Cell Significance Index: -27.6500
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.2571
    Cell Significance Index: -11.6600
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.2666
    Cell Significance Index: -17.9300
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.2758
    Cell Significance Index: -32.1400
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: -0.3088
    Cell Significance Index: -3.9600
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.4355
    Cell Significance Index: -8.5000
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.4759
    Cell Significance Index: -13.5800
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.5056
    Cell Significance Index: -52.6400
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.5331
    Cell Significance Index: -11.5500
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.5587
    Cell Significance Index: -44.2500
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.5739
    Cell Significance Index: -6.5200
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.5941
    Cell Significance Index: -15.9200
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: -0.6293
    Cell Significance Index: -3.9100
  • Cell Name: theca cell (CL0000503)
    Fold Change: -0.6485
    Cell Significance Index: -3.8100
  • Cell Name: perivascular cell (CL4033054)
    Fold Change: -0.6866
    Cell Significance Index: -3.1700
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.6913
    Cell Significance Index: -22.1400
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.7925
    Cell Significance Index: -21.2000
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.8075
    Cell Significance Index: -20.6300
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.8076
    Cell Significance Index: -13.8400
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.8672
    Cell Significance Index: -38.3600
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.9017
    Cell Significance Index: -55.2800
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.9815
    Cell Significance Index: -23.5400

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** UFM1 is a protein that belongs to the UFM family, which is involved in the covalent modification of ubiquitin. UFM1 specifically recognizes and modifies ubiquitin, leading to the stabilization of protein complexes and the regulation of protein stability, localization, and activity. The protein is predominantly expressed in hematopoietic stem cells, progenitor cells, and various immune cells, suggesting its critical role in immune cell development and function. **Pathways and Functions:** UFM1 is implicated in several key pathways, including: 1. **Negative regulation of apoptotic process:** UFM1 has been shown to inhibit apoptosis by stabilizing anti-apoptotic proteins, thereby promoting cell survival and proliferation. 2. **Negative regulation of protein import into nucleus:** UFM1 modulates the nuclear import of proteins, influencing gene expression and cellular regulation. 3. **Protein ufmylation:** UFM1 catalyzes the formation of ufmylated proteins, which are involved in various cellular processes, including protein degradation and protein stability. 4. **Regulation of intracellular estrogen receptor signaling pathway:** UFM1 has been shown to modulate the activity of estrogen receptors, influencing cell growth, differentiation, and survival. 5. **Response to endoplasmic reticulum stress:** UFM1 helps to mitigate ER stress by regulating the activity of ER-associated chaperones and modulating protein homeostasis. **Clinical Significance:** UFM1's involvement in various cellular processes has significant implications for immunological research and clinical applications. Specifically: 1. **Hematological disorders:** Abnormalities in UFM1 expression have been linked to hematological disorders, such as myelodysplastic syndromes and acute leukemia. 2. **Immunotherapy:** Understanding UFM1's role in immune cell function and tumor immune evasion may lead to the development of novel immunotherapeutic strategies. 3. **Cancer research:** UFM1's involvement in protein stability and regulation of apoptotic pathways make it a promising target for cancer research and therapeutic intervention. 4. **Regenerative medicine:** UFM1's role in stem cell biology and tissue regeneration may have implications for the development of novel regenerative therapies. In conclusion, UFM1 is a multifunctional protein that plays a critical role in regulating various cellular processes, including protein modification, apoptosis, and response to endoplasmic reticulum stress. Further research on UFM1's mechanisms and clinical significance will provide valuable insights into its role in immunological processes and the development of novel therapeutic strategies.

Genular Protein ID: 499789630

Symbol: UFM1_HUMAN

Name: N/A

UniProtKB Accession Codes:

P61960 Q14346 Q5VXS0 Q6IAG6 Q9CPX2 Q9NZF2

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 7 EMDB 3 Ensembl 2 EvolutionaryTrace 1 ExpressionAtlas 1 GO 11 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 2 KEGG 1 MANE-Select 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PDB 12 PDBsum 12 PIRSF 1 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 RefSeq 5 SASBDB 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TopDownProteomics 2 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 15071506

Title: A novel protein-conjugating system for Ufm1, a ubiquitin-fold modifier.

PubMed ID: 15071506

DOI: 10.1038/sj.emboj.7600205

PubMed ID: 11042152

Title: Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells.

PubMed ID: 11042152

DOI: 10.1101/gr.140200

PubMed ID: 16344560

Title: Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes.

PubMed ID: 16344560

DOI: 10.1101/gr.4039406

PubMed ID: 15057823

Title: The DNA sequence and analysis of human chromosome 13.

PubMed ID: 15057823

DOI: 10.1038/nature02379

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 20018847

Title: A novel type of E3 ligase for the Ufm1 conjugation system.

PubMed ID: 20018847

DOI: 10.1074/jbc.m109.036814

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 23152784

Title: Transcriptional regulation of the Ufm1 conjugation system in response to disturbance of the endoplasmic reticulum homeostasis and inhibition of vesicle trafficking.

PubMed ID: 23152784

DOI: 10.1371/journal.pone.0048587

PubMed ID: 25219498

Title: Modification of ASC1 by UFM1 is crucial for ERalpha transactivation and breast cancer development.

PubMed ID: 25219498

DOI: 10.1016/j.molcel.2014.08.007

PubMed ID: 26872069

Title: UBA5 mutations cause a new form of autosomal recessive cerebellar ataxia.

PubMed ID: 26872069

DOI: 10.1371/journal.pone.0149039

PubMed ID: 28931644

Title: founder mutation in the Roma population causes recessive variant of H-ABC.

PubMed ID: 28931644

DOI: 10.1212/wnl.0000000000004578

PubMed ID: 29868776

Title: Biallelic UFM1 and UFC1 mutations expand the essential role of ufmylation in brain development.

PubMed ID: 29868776

DOI: 10.1093/brain/awy135

PubMed ID: 29295865

Title: Trans-binding of UFM1 to UBA5 stimulates UBA5 homodimerization and ATP binding.

PubMed ID: 29295865

DOI: 10.1096/fj.201701057r

PubMed ID: 30626644

Title: Ribosomal protein RPL26 is the principal target of UFMylation.

PubMed ID: 30626644

DOI: 10.1073/pnas.1816202116

PubMed ID: 32160526

Title: A genome-wide ER-phagy screen highlights key roles of mitochondrial metabolism and ER-Resident UFMylation.

PubMed ID: 32160526

DOI: 10.1016/j.cell.2020.02.017

PubMed ID: 35926457

Title: Human UFSP1 is an active protease that regulates UFM1 maturation and UFMylation.

PubMed ID: 35926457

DOI: 10.1016/j.celrep.2022.111168

PubMed ID: 35525273

Title: Human UFSP1 translated from an upstream near-cognate initiation codon functions as an active UFM1-specific protease.

PubMed ID: 35525273

DOI: 10.1016/j.jbc.2022.102016

PubMed ID: 38377992

Title: UFL1 ablation in T cells suppresses PD-1 UFMylation to enhance anti-tumor immunity.

PubMed ID: 38377992

DOI: 10.1016/j.molcel.2024.01.024

PubMed ID: 16527251

Title: Solution structure and dynamics of Ufm1, a ubiquitin-fold modifier 1.

PubMed ID: 16527251

DOI: 10.1016/j.bbrc.2006.02.107

PubMed ID: 27653677

Title: Trans-binding mechanism of ubiquitin-like protein activation revealed by a UBA5-UFM1 Complex.

PubMed ID: 27653677

DOI: 10.1016/j.celrep.2016.08.067

PubMed ID: 26929408

Title: Structural and functional analysis of a novel interaction motif within UFM1-activating enzyme 5 (UBA5) required for binding to ubiquitin-like proteins and ufmylation.

PubMed ID: 26929408

DOI: 10.1074/jbc.m116.715474

PubMed ID: 28360427

Title: Novel insights into the interaction of UBA5 with UFM1 via a UFM1-interacting sequence.

PubMed ID: 28360427

DOI: 10.1038/s41598-017-00610-0

PubMed ID: 30412706

Title: An N-terminal extension to UBA5 adenylation domain boosts UFM1 activation: isoform-specific differences in ubiquitin-like protein activation.

PubMed ID: 30412706

DOI: 10.1016/j.jmb.2018.10.007

PubMed ID: 38383785

Title: UFM1 E3 ligase promotes recycling of 60S ribosomal subunits from the ER.

PubMed ID: 38383785

DOI: 10.1038/s41586-024-07073-0

Sequence Information:

  • Length: 85
  • Mass: 9118
  • Checksum: EDB2412E5E5836D8
  • Sequence:
    • MSKVSFKITL TSDPRLPYKV LSVPESTPFT AVLKFAAEEF KVPAATSAII TNDGIGINPA 
QTAGNVFLKH GSELRIIPRD RVGSC

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.