PSMA1 | ENSG00000129084 | NCBI 5682

Details for: PSMA1

Gene ID: 5682

Symbol: PSMA1

Ensembl ID: ENSG00000129084

Description: proteasome 20S subunit alpha 1

Associated with

Abc-family proteins mediated transport
(R-HSA-382556)
Abc transporter disorders
(R-HSA-5619084)
Adaptive immune system
(R-HSA-1280218)
Antigen processing-cross presentation
(R-HSA-1236975)
Apc/c-mediated degradation of cell cycle proteins
(R-HSA-174143)
Apoptosis
(R-HSA-109581)
Assembly of the pre-replicative complex
(R-HSA-68867)
Auf1 (hnrnp d0) binds and destabilizes mrna
(R-HSA-450408)
Axon guidance
(R-HSA-422475)
Beta-catenin independent wnt signaling
(R-HSA-3858494)
C-type lectin receptors (clrs)
(R-HSA-5621481)
Cell cycle
(R-HSA-1640170)
Cell cycle, mitotic
(R-HSA-69278)
Cell cycle checkpoints
(R-HSA-69620)
Cellular responses to stimuli
(R-HSA-8953897)
Cellular responses to stress
(R-HSA-2262752)
Cellular response to chemical stress
(R-HSA-9711123)
Cellular response to hypoxia
(R-HSA-1234174)
Class i mhc mediated antigen processing & presentation
(R-HSA-983169)
Clec7a (dectin-1) signaling
(R-HSA-5607764)
Cytokine signaling in immune system
(R-HSA-1280215)
Defective cftr causes cystic fibrosis
(R-HSA-5678895)
Degradation of axin
(R-HSA-4641257)
Degradation of beta-catenin by the destruction complex
(R-HSA-195253)
Degradation of dvl
(R-HSA-4641258)
Degradation of gli1 by the proteasome
(R-HSA-5610780)
Degradation of gli2 by the proteasome
(R-HSA-5610783)
Deubiquitination
(R-HSA-5688426)
Developmental biology
(R-HSA-1266738)
Disease
(R-HSA-1643685)
Diseases of signal transduction by growth factor receptors and second messengers
(R-HSA-5663202)
Disorders of transmembrane transporters
(R-HSA-5619115)
Dna replication
(R-HSA-69306)
Dna replication pre-initiation
(R-HSA-69002)
Downstream signaling events of b cell receptor (bcr)
(R-HSA-1168372)
Downstream tcr signaling
(R-HSA-202424)
Fc epsilon receptor (fceri) signaling
(R-HSA-2454202)
Fceri mediated nf-kb activation
(R-HSA-2871837)
Formation of paraxial mesoderm
(R-HSA-9793380)
G1/s dna damage checkpoints
(R-HSA-69615)
G2/m checkpoints
(R-HSA-69481)
Gastrulation
(R-HSA-9758941)
Gene expression (transcription)
(R-HSA-74160)
Generic transcription pathway
(R-HSA-212436)
Gli3 is processed to gli3r by the proteasome
(R-HSA-5610785)
Hedgehog 'off' state
(R-HSA-5610787)
Hedgehog 'on' state
(R-HSA-5632684)
Hedgehog ligand biogenesis
(R-HSA-5358346)
Hh mutants abrogate ligand secretion
(R-HSA-5387390)
Hh mutants are degraded by erad
(R-HSA-5362768)
Hiv infection
(R-HSA-162906)
Immune system
(R-HSA-168256)
Infectious disease
(R-HSA-5663205)
Innate immune system
(R-HSA-168249)
Interleukin-1 family signaling
(R-HSA-446652)
Intracellular signaling by second messengers
(R-HSA-9006925)
Mapk1/mapk3 signaling
(R-HSA-5684996)
Mapk6/mapk4 signaling
(R-HSA-5687128)
Mapk family signaling cascades
(R-HSA-5683057)
Metabolism
(R-HSA-1430728)
Metabolism of amino acids and derivatives
(R-HSA-71291)
Metabolism of polyamines
(R-HSA-351202)
Metabolism of proteins
(R-HSA-392499)
Metabolism of rna
(R-HSA-8953854)
Mitotic g1 phase and g1/s transition
(R-HSA-453279)
Mitotic g2-g2/m phases
(R-HSA-453274)
Mitotic metaphase and anaphase
(R-HSA-2555396)
M phase
(R-HSA-68886)
Neddylation
(R-HSA-8951664)
Nervous system development
(R-HSA-9675108)
Nik-->noncanonical nf-kb signaling
(R-HSA-5676590)
Oxygen-dependent proline hydroxylation of hypoxia-inducible factor alpha
(R-HSA-1234176)
Pcp/ce pathway
(R-HSA-4086400)
Pip3 activates akt signaling
(R-HSA-1257604)
Post-translational protein modification
(R-HSA-597592)
Programmed cell death
(R-HSA-5357801)
Proteasome assembly
(R-HSA-9907900)
Raf/map kinase cascade
(R-HSA-5673001)
Regulation of activated pak-2p34 by proteasome mediated degradation
(R-HSA-211733)
Regulation of apoptosis
(R-HSA-169911)
Regulation of mitotic cell cycle
(R-HSA-453276)
Regulation of mrna stability by proteins that bind au-rich elements
(R-HSA-450531)
Regulation of ornithine decarboxylase (odc)
(R-HSA-350562)
Rna polymerase ii transcription
(R-HSA-73857)
Signaling by hedgehog
(R-HSA-5358351)
Signaling by interleukins
(R-HSA-449147)
Signaling by notch
(R-HSA-157118)
Signaling by notch4
(R-HSA-9013694)
Signaling by robo receptors
(R-HSA-376176)
Signaling by the b cell receptor (bcr)
(R-HSA-983705)
Signaling by wnt
(R-HSA-195721)
Signal transduction
(R-HSA-162582)
S phase
(R-HSA-69242)
Tcf dependent signaling in response to wnt
(R-HSA-201681)
Tcr signaling
(R-HSA-202403)
Tnfr2 non-canonical nf-kb pathway
(R-HSA-5668541)
Transport of small molecules
(R-HSA-382551)
Ub-specific processing proteases
(R-HSA-5689880)
Uch proteinases
(R-HSA-5689603)
Viral infection pathways
(R-HSA-9824446)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: embryonic stem cell (CL0002322)
Fold Change: 195.2069
Cell Significance Index: -80.4200
Cell Name: smooth muscle fiber of ileum (CL1000278)
Fold Change: 158.9206
Cell Significance Index: -75.0300
Cell Name: peripheral blood mononuclear cell (CL2000001)
Fold Change: 144.2596
Cell Significance Index: -74.2100
Cell Name: ileal goblet cell (CL1000326)
Fold Change: 112.4851
Cell Significance Index: -75.4800
Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
Fold Change: 20.0272
Cell Significance Index: -53.6500
Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
Fold Change: 18.0729
Cell Significance Index: -55.5100
Cell Name: epidermal Langerhans cell (CL0002457)
Fold Change: 8.5123
Cell Significance Index: -18.6300
Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
Fold Change: 2.7604
Cell Significance Index: 81.0700
Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
Fold Change: 2.6702
Cell Significance Index: 92.7900
Cell Name: kidney cell (CL1000497)
Fold Change: 2.5488
Cell Significance Index: 20.3500
Cell Name: fibroblast of dermis (CL0002551)
Fold Change: 2.4628
Cell Significance Index: 51.5500
Cell Name: fibroblast of mammary gland (CL0002555)
Fold Change: 2.2646
Cell Significance Index: 64.9200
Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
Fold Change: 2.2173
Cell Significance Index: 104.2100
Cell Name: early pro-B cell (CL0002046)
Fold Change: 2.1790
Cell Significance Index: 140.5800
Cell Name: skeletal muscle myoblast (CL0000515)
Fold Change: 2.0159
Cell Significance Index: 21.9200
Cell Name: stromal cell of ovary (CL0002132)
Fold Change: 2.0128
Cell Significance Index: 276.4100
Cell Name: basal cell of urothelium (CL1000486)
Fold Change: 1.9583
Cell Significance Index: 240.8000
Cell Name: intermediate cell of urothelium (CL4030055)
Fold Change: 1.8877
Cell Significance Index: 340.3000
Cell Name: neoplastic cell (CL0001063)
Fold Change: 1.7902
Cell Significance Index: 355.2800
Cell Name: cell in vitro (CL0001034)
Fold Change: 1.7091
Cell Significance Index: 933.3800
Cell Name: basal cell of prostate epithelium (CL0002341)
Fold Change: 1.6621
Cell Significance Index: 45.2400
Cell Name: lactocyte (CL0002325)
Fold Change: 1.5959
Cell Significance Index: 206.1800
Cell Name: endothelial cell of venule (CL1000414)
Fold Change: 1.5844
Cell Significance Index: 18.0000
Cell Name: sebum secreting cell (CL0000317)
Fold Change: 1.4858
Cell Significance Index: 105.0800
Cell Name: hair follicular keratinocyte (CL2000092)
Fold Change: 1.4622
Cell Significance Index: 646.4700
Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: 1.4541
Cell Significance Index: 108.3700
Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: 1.4091
Cell Significance Index: 282.6700
Cell Name: umbrella cell of urothelium (CL4030056)
Fold Change: 1.2314
Cell Significance Index: 11.3400
Cell Name: gut absorptive cell (CL0000677)
Fold Change: 1.1281
Cell Significance Index: 67.7300
Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: 1.0741
Cell Significance Index: 50.0800
Cell Name: odontoblast (CL0000060)
Fold Change: 0.9881
Cell Significance Index: 126.6700
Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: 0.9393
Cell Significance Index: 336.9100
Cell Name: bladder urothelial cell (CL1001428)
Fold Change: 0.6669
Cell Significance Index: 34.6500
Cell Name: vascular lymphangioblast (CL0005022)
Fold Change: 0.6414
Cell Significance Index: 11.3400
Cell Name: glycinergic neuron (CL1001509)
Fold Change: 0.5910
Cell Significance Index: 31.0300
Cell Name: granulosa cell (CL0000501)
Fold Change: 0.5271
Cell Significance Index: 13.8600
Cell Name: retinal progenitor cell (CL0002672)
Fold Change: 0.3945
Cell Significance Index: 22.1400
Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: 0.3858
Cell Significance Index: 29.6100
Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: 0.3435
Cell Significance Index: 58.6500
Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: 0.1718
Cell Significance Index: 32.6900
Cell Name: pulmonary alveolar epithelial cell (CL0000322)
Fold Change: 0.1111
Cell Significance Index: 84.0700
Cell Name: anterior lens cell (CL0002223)
Fold Change: 0.1044
Cell Significance Index: 192.4800
Cell Name: mesenchymal cell (CL0008019)
Fold Change: 0.0869
Cell Significance Index: 1.4600
Cell Name: tonsil germinal center B cell (CL2000006)
Fold Change: 0.0863
Cell Significance Index: 10.1800
Cell Name: lens epithelial cell (CL0002224)
Fold Change: 0.0450
Cell Significance Index: 69.2200
Cell Name: placental villous trophoblast (CL2000060)
Fold Change: 0.0393
Cell Significance Index: 1.0500
Cell Name: small intestine goblet cell (CL1000495)
Fold Change: 0.0323
Cell Significance Index: 1.1400
Cell Name: cerebellar granule cell (CL0001031)
Fold Change: -0.0032
Cell Significance Index: -0.0600
Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
Fold Change: -0.0091
Cell Significance Index: -6.6700
Cell Name: forebrain neuroblast (CL1000042)
Fold Change: -0.0093
Cell Significance Index: -0.5700
Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: -0.0245
Cell Significance Index: -46.2200
Cell Name: pancreatic A cell (CL0000171)
Fold Change: -0.0260
Cell Significance Index: -19.2600
Cell Name: pancreatic PP cell (CL0002275)
Fold Change: -0.0572
Cell Significance Index: -35.7200
Cell Name: secondary lens fiber (CL0002225)
Fold Change: -0.0592
Cell Significance Index: -80.4900
Cell Name: type B pancreatic cell (CL0000169)
Fold Change: -0.0881
Cell Significance Index: -49.7000
Cell Name: abnormal cell (CL0001061)
Fold Change: -0.0945
Cell Significance Index: -9.6500
Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: -0.1037
Cell Significance Index: -65.8900
Cell Name: eye photoreceptor cell (CL0000287)
Fold Change: -0.1047
Cell Significance Index: -6.6000
Cell Name: pancreatic D cell (CL0000173)
Fold Change: -0.1407
Cell Significance Index: -29.6400
Cell Name: colon goblet cell (CL0009039)
Fold Change: -0.1536
Cell Significance Index: -15.2000
Cell Name: ciliary muscle cell (CL1000443)
Fold Change: -0.1614
Cell Significance Index: -73.2400
Cell Name: indirect pathway medium spiny neuron (CL4023029)
Fold Change: -0.1862
Cell Significance Index: -8.2400
Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: -0.2343
Cell Significance Index: -10.6200
Cell Name: dopaminergic neuron (CL0000700)
Fold Change: -0.2656
Cell Significance Index: -76.4200
Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: -0.2688
Cell Significance Index: -30.7900
Cell Name: peg cell (CL4033014)
Fold Change: -0.3082
Cell Significance Index: -7.1200
Cell Name: fibro/adipogenic progenitor cell (CL0009099)
Fold Change: -0.3184
Cell Significance Index: -16.0900
Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: -0.3634
Cell Significance Index: -11.6400
Cell Name: pro-T cell (CL0000827)
Fold Change: -0.3824
Cell Significance Index: -9.7700
Cell Name: epithelial cell of stomach (CL0002178)
Fold Change: -0.4082
Cell Significance Index: -47.5700
Cell Name: direct pathway medium spiny neuron (CL4023026)
Fold Change: -0.4238
Cell Significance Index: -16.0500
Cell Name: pancreatic endocrine cell (CL0008024)
Fold Change: -0.4371
Cell Significance Index: -49.9000
Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: -0.4885
Cell Significance Index: -71.0100
Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
Fold Change: -0.5676
Cell Significance Index: -10.4900
Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: -0.6006
Cell Significance Index: -17.3100
Cell Name: paneth cell of epithelium of small intestine (CL1000343)
Fold Change: -0.6638
Cell Significance Index: -14.3800
Cell Name: centrilobular region hepatocyte (CL0019029)
Fold Change: -0.6667
Cell Significance Index: -11.2300
Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
Fold Change: -0.6819
Cell Significance Index: -54.0100
Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: -0.6846
Cell Significance Index: -71.2800
Cell Name: hippocampal granule cell (CL0001033)
Fold Change: -0.7098
Cell Significance Index: -47.7300
Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
Fold Change: -0.8026
Cell Significance Index: -22.4300
Cell Name: neuron associated cell (CL0000095)
Fold Change: -0.9093
Cell Significance Index: -37.2600
Cell Name: conjunctival epithelial cell (CL1000432)
Fold Change: -0.9162
Cell Significance Index: -12.5000
Cell Name: kidney epithelial cell (CL0002518)
Fold Change: -0.9462
Cell Significance Index: -27.8700
Cell Name: paneth cell of colon (CL0009009)
Fold Change: -0.9507
Cell Significance Index: -14.2500
Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
Fold Change: -0.9588
Cell Significance Index: -20.4200
Cell Name: intestinal tuft cell (CL0019032)
Fold Change: -1.0087
Cell Significance Index: -61.8400
Cell Name: neutrophil progenitor cell (CL0000834)
Fold Change: -1.1114
Cell Significance Index: -29.7300
Cell Name: periportal region hepatocyte (CL0019026)
Fold Change: -1.1582
Cell Significance Index: -17.1000
Cell Name: skeletal muscle fiber (CL0008002)
Fold Change: -1.2515
Cell Significance Index: -32.1700
Cell Name: endothelial cell of placenta (CL0009092)
Fold Change: -1.3812
Cell Significance Index: -8.3400
Cell Name: cortical interneuron (CL0008031)
Fold Change: -1.4996
Cell Significance Index: -35.9700
Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
Fold Change: -1.5256
Cell Significance Index: -32.3800
Cell Name: thyroid follicular cell (CL0002258)
Fold Change: -1.5605
Cell Significance Index: -16.5800
Cell Name: L6b glutamatergic cortical neuron (CL4023038)
Fold Change: -1.5776
Cell Significance Index: -51.6500
Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
Fold Change: -1.6830
Cell Significance Index: -53.6000
Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
Fold Change: -1.6862
Cell Significance Index: -59.0700
Cell Name: stratified epithelial cell (CL0000079)
Fold Change: -1.6903
Cell Significance Index: -62.0500
Cell Name: microcirculation associated smooth muscle cell (CL0008035)
Fold Change: -1.7465
Cell Significance Index: -14.6700
Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
Fold Change: -1.7838
Cell Significance Index: -30.7500

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

**Key Characteristics:** PSMA1 is a member of the proteasome family, which is a complex of protein complexes responsible for degrading ubiquitinated proteins. PSMA1 is specifically expressed in various cell types, including kidney proximal convoluted tubule epithelial cells, epicardial adipocytes, myeloid dendritic cells, and basal cells of prostate epithelium. The gene is highly conserved across species, suggesting its critical role in maintaining cellular homeostasis. **Pathways and Functions:** PSMA1 is involved in various cellular pathways, including: 1. **Antigen Processing and Presentation:** PSMA1 plays a crucial role in the degradation of ubiquitinated antigens, which are then presented to T-cells via MHC class I molecules. 2. **Cell Cycle Regulation:** PSMA1 is involved in the degradation of cell cycle regulators, such as p21 and p27, which are essential for cell cycle progression. 3. **Apoptosis:** PSMA1 is involved in the regulation of apoptosis by degrading pro-apoptotic proteins, such as BAX and BAK. 4. **Signaling Pathways:** PSMA1 is involved in various signaling pathways, including the NF-κB, MAPK, and WNT signaling pathways. **Clinical Significance:** Dysregulation of PSMA1 has been implicated in various diseases, including: 1. **Prostate Cancer:** Overexpression of PSMA1 has been observed in prostate cancer cells, suggesting its potential as a therapeutic target. 2. **Autoimmune Diseases:** Dysregulation of PSMA1 has been implicated in autoimmune diseases, such as rheumatoid arthritis and multiple sclerosis. 3. **Infectious Diseases:** PSMA1 has been shown to play a role in the regulation of immune responses to viral infections, such as HIV. 4. **Neurodegenerative Diseases:** Dysregulation of PSMA1 has been implicated in neurodegenerative diseases, such as Alzheimer's and Parkinson's disease. **Conclusion:** PSMA1 is a critical gene that plays a pivotal role in regulating various cellular processes, including antigen presentation, cell cycle progression, and apoptosis. Its dysregulation has been implicated in various diseases, including prostate cancer, autoimmune diseases, infectious diseases, and neurodegenerative diseases. Further research is necessary to fully elucidate the role of PSMA1 in immune regulation and disease, and to explore its potential as a therapeutic target. **Recommendations:** 1. **Further Research:** Investigate the role of PSMA1 in different diseases and explore its potential as a therapeutic target. 2. **Immunotherapy:** Develop immunotherapies that target PSMA1 to treat diseases, such as prostate cancer and autoimmune diseases. 3. **Protein Degradation:** Investigate the role of PSMA1 in protein degradation and explore its potential as a therapeutic target for diseases, such as neurodegenerative diseases. **Limitations:** 1. **Limited Understanding:** The role of PSMA1 in immune regulation and disease is not fully understood, and further research is necessary to elucidate its mechanisms. 2. **Limited Therapeutic Options:** The development of therapeutic options targeting PSMA1 is limited, and further research is necessary to explore its potential as a therapeutic target. **Future Directions:** 1. **Immunotherapy:** Develop immunotherapies that target PSMA1 to treat diseases, such as prostate cancer and autoimmune diseases. 2. **Protein Degradation:** Investigate the role of PSMA1 in protein degradation and explore its potential as a therapeutic target for diseases, such as neurodegenerative diseases. 3. **Gene Editing:** Explore the use of gene editing technologies to modify PSMA1 expression and treat diseases.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

30 kDa prosomal protein
B4E0X6_HUMAN

Genular Protein ID: 2469392409

Symbol: PSA1_HUMAN

Name: 30 kDa prosomal protein

UniProtKB Accession Codes:

P25786 A8K400 Q53YE8 Q9BRV9

Database IDs:

Citations:

PubMed ID: 1888762

Title: The primary structures of four subunits of the human, high-molecular-weight proteinase, macropain (proteasome), are distinct but homologous.

PubMed ID: 1888762

DOI: 10.1016/0167-4838(91)90020-z

PubMed ID: 2025653

Title: Molecular cloning and sequence analysis of cDNAs for five major subunits of human proteasomes (multi-catalytic proteinase complexes).

PubMed ID: 2025653

DOI: 10.1016/0167-4781(91)90090-9

PubMed ID: 1398136

Title: Two mRNAs exist for the Hs PROS-30 gene encoding a component of human prosomes.

PubMed ID: 1398136

DOI: 10.1016/0378-1119(92)90098-a

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 7811265

Title: Human proteasome subunits from 2-dimensional gels identified by partial sequencing.

PubMed ID: 7811265

DOI: 10.1006/bbrc.1994.2876

PubMed ID: 8610016

Title: A role for the proteasome regulator PA28alpha in antigen presentation.

PubMed ID: 8610016

DOI: 10.1038/381166a0

PubMed ID: 12181345

Title: Clastosome: a subtype of nuclear body enriched in 19S and 20S proteasomes, ubiquitin, and protein substrates of proteasome.

PubMed ID: 12181345

DOI: 10.1091/mbc.e02-03-0122

PubMed ID: 15244466

Title: 20S proteasome prevents aggregation of heat-denatured proteins without PA700 regulatory subcomplex like a molecular chaperone.

PubMed ID: 15244466

DOI: 10.1021/bm049957a

PubMed ID: 17127214

Title: Comparative proteome analysis of breast cancer and adjacent normal breast tissues in human.

PubMed ID: 17127214

DOI: 10.1016/s1672-0229(06)60029-6

PubMed ID: 16317774

Title: The up-regulation of proteasome subunits and lysosomal proteases in hepatocellular carcinomas of the HBx gene knockin transgenic mice.

PubMed ID: 16317774

DOI: 10.1002/pmic.200500218

PubMed ID: 17292860

Title: Conserved signal peptide of Notch3 inhibits interaction with proteasome.

PubMed ID: 17292860

DOI: 10.1016/j.bbrc.2007.01.151

PubMed ID: 17323924

Title: Mass spectrometric characterization of the affinity-purified human 26S proteasome complex.

PubMed ID: 17323924

DOI: 10.1021/bi061994u

PubMed ID: 17004105

Title: Over-expression of genes and proteins of ubiquitin specific peptidases (USPs) and proteasome subunits (PSs) in breast cancer tissue observed by the methods of RFDD-PCR and proteomics.

PubMed ID: 17004105

DOI: 10.1007/s10549-006-9393-7

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 23495936

Title: Molecular architecture and assembly of the eukaryotic proteasome.

PubMed ID: 23495936

DOI: 10.1146/annurev-biochem-060410-150257

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 27176742

Title: Human 20S proteasome activity towards fluorogenic peptides of various chain lengths.

PubMed ID: 27176742

DOI: 10.1515/hsz-2016-0176

PubMed ID: 29804830

Title: ZFAND1 recruits p97 and the 26S proteasome to promote the clearance of arsenite-induced stress granules.

PubMed ID: 29804830

DOI: 10.1016/j.molcel.2018.04.021

PubMed ID: 26133119

Title: Cryo-EM reveals the conformation of a substrate analogue in the human 20S proteasome core.

PubMed ID: 26133119

DOI: 10.1038/ncomms8573

PubMed ID: 25599644

Title: Crystal structure of the human 20S proteasome in complex with carfilzomib.

PubMed ID: 25599644

DOI: 10.1016/j.str.2014.11.017

PubMed ID: 27428775

Title: An atomic structure of the human 26S proteasome.

PubMed ID: 27428775

DOI: 10.1038/nsmb.3273

PubMed ID: 27342858

Title: Structure of the human 26S proteasome at a resolution of 3.9 Aa.

PubMed ID: 27342858

DOI: 10.1073/pnas.1608050113

PubMed ID: 27493187

Title: The inhibition mechanism of human 20S proteasomes enables next-generation inhibitor design.

PubMed ID: 27493187

DOI: 10.1126/science.aaf8993

PubMed ID: 34711951

Title: AKIRIN2 controls the nuclear import of proteasomes in vertebrates.

PubMed ID: 34711951

DOI: 10.1038/s41586-021-04035-8

Sequence Information:

Length: 263
Mass: 29556
Checksum: 3F159C5BCEFE8DED
Sequence:

MFRNQYDNDV TVWSPQGRIH QIEYAMEAVK QGSATVGLKS KTHAVLVALK RAQSELAAHQ 
KKILHVDNHI GISIAGLTAD ARLLCNFMRQ ECLDSRFVFD RPLPVSRLVS LIGSKTQIPT 
QRYGRRPYGV GLLIAGYDDM GPHIFQTCPS ANYFDCRAMS IGARSQSART YLERHMSEFM 
ECNLNELVKH GLRALRETLP AEQDLTTKNV SIGIVGKDLE FTIYDDDDVS PFLEGLEERP 
QRKAQPAQPA DEPAEKADEP MEH

Genular Protein ID: 4178656589

Symbol: B4E0X6_HUMAN

Name: N/A

UniProtKB Accession Codes:

B4E0X6

Database IDs:

Sequence Information:

Length: 130
Mass: 14624
Checksum: 07D2AEDF4AAF7CC4
Sequence:

MFRNQYDNDV TVWSPQGRIH QIEYAMEAVK QGSATVGLKS KTHAVLVALK RAQSELAAHQ 
KKILHVDNHI GISIAGLTAD ARLLCNFMRQ ECLDSRFVFD RPLPVSRLVS LIGSSILFML 
AFMDMNFEGF

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: PSMA1

Associated with

Cells (max top 100)

Other Information

The primary structures of four subunits of the human, high-molecular-weight proteinase, macropain (proteasome), are distinct but homologous. PubMed ID: 1888762

Molecular cloning and sequence analysis of cDNAs for five major subunits of human proteasomes (multi-catalytic proteinase complexes). PubMed ID: 2025653

Two mRNAs exist for the Hs PROS-30 gene encoding a component of human prosomes. PubMed ID: 1398136

Complete sequencing and characterization of 21,243 full-length human cDNAs. PubMed ID: 14702039

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Human proteasome subunits from 2-dimensional gels identified by partial sequencing. PubMed ID: 7811265

A role for the proteasome regulator PA28alpha in antigen presentation. PubMed ID: 8610016

Clastosome: a subtype of nuclear body enriched in 19S and 20S proteasomes, ubiquitin, and protein substrates of proteasome. PubMed ID: 12181345

20S proteasome prevents aggregation of heat-denatured proteins without PA700 regulatory subcomplex like a molecular chaperone. PubMed ID: 15244466

Comparative proteome analysis of breast cancer and adjacent normal breast tissues in human. PubMed ID: 17127214

The up-regulation of proteasome subunits and lysosomal proteases in hepatocellular carcinomas of the HBx gene knockin transgenic mice. PubMed ID: 16317774

Conserved signal peptide of Notch3 inhibits interaction with proteasome. PubMed ID: 17292860

Mass spectrometric characterization of the affinity-purified human 26S proteasome complex. PubMed ID: 17323924

Over-expression of genes and proteins of ubiquitin specific peptidases (USPs) and proteasome subunits (PSs) in breast cancer tissue observed by the methods of RFDD-PCR and proteomics. PubMed ID: 17004105

Initial characterization of the human central proteome. PubMed ID: 21269460

Molecular architecture and assembly of the eukaryotic proteasome. PubMed ID: 23495936

Toward a comprehensive characterization of a human cancer cell phosphoproteome. PubMed ID: 23186163

An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. PubMed ID: 24275569

N-terminome analysis of the human mitochondrial proteome. PubMed ID: 25944712

Human 20S proteasome activity towards fluorogenic peptides of various chain lengths. PubMed ID: 27176742

ZFAND1 recruits p97 and the 26S proteasome to promote the clearance of arsenite-induced stress granules. PubMed ID: 29804830

Cryo-EM reveals the conformation of a substrate analogue in the human 20S proteasome core. PubMed ID: 26133119

Crystal structure of the human 20S proteasome in complex with carfilzomib. PubMed ID: 25599644

An atomic structure of the human 26S proteasome. PubMed ID: 27428775

Structure of the human 26S proteasome at a resolution of 3.9 Aa. PubMed ID: 27342858

The inhibition mechanism of human 20S proteasomes enables next-generation inhibitor design. PubMed ID: 27493187

AKIRIN2 controls the nuclear import of proteasomes in vertebrates. PubMed ID: 34711951