Details for: MYH13

Gene ID: 8735

Symbol: MYH13

Ensembl ID: ENSG00000006788

Description: myosin heavy chain 13

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: 0.9726
    Cell Significance Index: 6.5900
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.9234
    Cell Significance Index: 13.2600
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 0.8152
    Cell Significance Index: 20.3300
  • Cell Name: acinar cell (CL0000622)
    Fold Change: 0.6783
    Cell Significance Index: 8.5200
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 0.3064
    Cell Significance Index: 5.2500
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: 0.3036
    Cell Significance Index: 3.9100
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: 0.2169
    Cell Significance Index: 1.4400
  • Cell Name: uterine smooth muscle cell (CL0002601)
    Fold Change: 0.2089
    Cell Significance Index: 2.0000
  • Cell Name: photoreceptor cell (CL0000210)
    Fold Change: 0.2022
    Cell Significance Index: 2.8400
  • Cell Name: adipocyte of breast (CL0002617)
    Fold Change: 0.1509
    Cell Significance Index: 1.9000
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: 0.1440
    Cell Significance Index: 1.4900
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: 0.0838
    Cell Significance Index: 1.4100
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: 0.0772
    Cell Significance Index: 1.1400
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: 0.0599
    Cell Significance Index: 1.1700
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0424
    Cell Significance Index: 78.1600
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.0317
    Cell Significance Index: 5.4200
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0313
    Cell Significance Index: 48.1900
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.0311
    Cell Significance Index: 0.8700
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.0301
    Cell Significance Index: 5.9800
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 0.0297
    Cell Significance Index: 2.0000
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.0292
    Cell Significance Index: 5.8500
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: 0.0124
    Cell Significance Index: 0.3100
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.0087
    Cell Significance Index: 0.1900
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 0.0084
    Cell Significance Index: 1.2200
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.0052
    Cell Significance Index: 3.6200
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 0.0038
    Cell Significance Index: 0.1500
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0031
    Cell Significance Index: 1.1200
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0031
    Cell Significance Index: 4.2000
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0021
    Cell Significance Index: 4.0200
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.0002
    Cell Significance Index: -0.0100
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0031
    Cell Significance Index: -1.9400
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0035
    Cell Significance Index: -1.5900
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.0037
    Cell Significance Index: -0.1000
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0046
    Cell Significance Index: -3.3800
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0059
    Cell Significance Index: -3.3100
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0060
    Cell Significance Index: -3.7600
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0064
    Cell Significance Index: -1.8300
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0065
    Cell Significance Index: -0.6700
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.0102
    Cell Significance Index: -0.1500
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0145
    Cell Significance Index: -0.8900
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0148
    Cell Significance Index: -2.6700
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0172
    Cell Significance Index: -3.6300
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0173
    Cell Significance Index: -2.3700
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.0203
    Cell Significance Index: -0.2900
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0206
    Cell Significance Index: -2.3600
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0268
    Cell Significance Index: -3.2900
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0275
    Cell Significance Index: -2.8600
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0289
    Cell Significance Index: -2.2200
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.0297
    Cell Significance Index: -0.7200
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: -0.0322
    Cell Significance Index: -0.3500
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: -0.0348
    Cell Significance Index: -0.8500
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0367
    Cell Significance Index: -1.1700
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.0369
    Cell Significance Index: -1.3600
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0389
    Cell Significance Index: -1.8200
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.0414
    Cell Significance Index: -2.1500
  • Cell Name: epithelial cell of prostate (CL0002231)
    Fold Change: -0.0438
    Cell Significance Index: -0.2700
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.0455
    Cell Significance Index: -1.4900
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.0498
    Cell Significance Index: -1.2800
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.0534
    Cell Significance Index: -1.8700
  • Cell Name: mesangial cell (CL0000650)
    Fold Change: -0.0545
    Cell Significance Index: -0.6900
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.0551
    Cell Significance Index: -1.1700
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0566
    Cell Significance Index: -3.1800
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.0575
    Cell Significance Index: -3.7100
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.0609
    Cell Significance Index: -1.3200
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0689
    Cell Significance Index: -3.2400
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.0698
    Cell Significance Index: -1.7400
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0700
    Cell Significance Index: -1.8700
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.0717
    Cell Significance Index: -1.4400
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.0730
    Cell Significance Index: -3.8000
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.0754
    Cell Significance Index: -1.4900
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.0763
    Cell Significance Index: -2.1800
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.0780
    Cell Significance Index: -0.9300
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.0817
    Cell Significance Index: -1.9600
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.0827
    Cell Significance Index: -1.7300
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: -0.0850
    Cell Significance Index: -1.2100
  • Cell Name: basal epithelial cell of prostatic duct (CL0002236)
    Fold Change: -0.0856
    Cell Significance Index: -0.7600
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.0909
    Cell Significance Index: -3.1600
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: -0.0917
    Cell Significance Index: -2.9000
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: -0.0920
    Cell Significance Index: -1.1800
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.0924
    Cell Significance Index: -2.6500
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: -0.0971
    Cell Significance Index: -1.2700
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.0978
    Cell Significance Index: -2.8800
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.1013
    Cell Significance Index: -3.5600
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: -0.1017
    Cell Significance Index: -1.4100
  • Cell Name: slow muscle cell (CL0000189)
    Fold Change: -0.1023
    Cell Significance Index: -1.5300
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.1054
    Cell Significance Index: -2.2000
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.1058
    Cell Significance Index: -1.2000
  • Cell Name: stromal cell of endometrium (CL0002255)
    Fold Change: -0.1139
    Cell Significance Index: -1.6200
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.1163
    Cell Significance Index: -3.3500
  • Cell Name: syncytiotrophoblast cell (CL0000525)
    Fold Change: -0.1179
    Cell Significance Index: -1.1200
  • Cell Name: type II muscle cell (CL0002212)
    Fold Change: -0.1190
    Cell Significance Index: -1.9200
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: -0.1209
    Cell Significance Index: -2.3800
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: -0.1229
    Cell Significance Index: -2.5000
  • Cell Name: ionocyte (CL0005006)
    Fold Change: -0.1234
    Cell Significance Index: -1.2900
  • Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
    Fold Change: -0.1294
    Cell Significance Index: -2.5800
  • Cell Name: L2/3 intratelencephalic projecting glutamatergic neuron (CL4030059)
    Fold Change: -0.1298
    Cell Significance Index: -1.7300
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -0.1301
    Cell Significance Index: -2.2500
  • Cell Name: melanocyte of skin (CL1000458)
    Fold Change: -0.1320
    Cell Significance Index: -1.8500
  • Cell Name: neuron (CL0000540)
    Fold Change: -0.1329
    Cell Significance Index: -1.2600
  • Cell Name: L6 intratelencephalic projecting glutamatergic neuron of the primary motor cortex (CL4023050)
    Fold Change: -0.1402
    Cell Significance Index: -1.8700

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Myosin-13 Protein Structure:** The MYH13 protein is a member of the myosin II family, characterized by its heavy chain (HC) and light chain (LC) subunits. The HC subunit contains the ATPase domain, responsible for hydrolyzing ATP and generating force for muscle contraction. 2. **Actin-Filament Binding:** The MYH13 protein exhibits high affinity for actin filaments, enabling it to regulate actin dynamics and modulate muscle contraction. 3. **Motor Activity:** MYH13 has been shown to possess motor activity, allowing it to move along actin filaments and generate force for muscle contraction. 4. **Cellular Expression:** The MYH13 gene is expressed in various cell types, including progenitor cells, retinal bipolar neurons, and cardiac tissue fibroblasts, highlighting its broad functional significance. **Pathways and Functions:** 1. **Muscle Contraction:** MYH13 plays a crucial role in regulating muscle contraction by modulating actin filament dynamics and generating force for muscle contraction. 2. **Cytoskeletal Dynamics:** The MYH13 protein regulates actin filament dynamics, influencing cytoskeletal organization and cell motility. 3. **Cell Motility:** MYH13 has been implicated in regulating cellular movement, including the migration of progenitor cells and the movement of retinal bipolar neurons. 4. **Regulation of Actin Filament Dynamics:** The MYH13 protein regulates actin filament dynamics, modulating the assembly and disassembly of actin filaments. **Clinical Significance:** 1. **Muscular Dystrophy:** Mutations in the MYH13 gene have been linked to muscular dystrophy, a group of genetic disorders characterized by progressive muscle weakness and degeneration. 2. **Cardiac Disease:** Alterations in MYH13 expression have been observed in cardiac disease, including hypertrophic cardiomyopathy and dilated cardiomyopathy. 3. **Neurological Disorders:** The MYH13 gene has been implicated in the regulation of retinal bipolar neuron movement and function, highlighting its potential role in neurological disorders such as retinitis pigmentosa. 4. **Cancer:** The MYH13 protein has been shown to regulate cellular motility and invasion, raising the possibility of its involvement in cancer development and progression. In conclusion, the MYH13 gene plays a critical role in regulating muscle contraction, cell motility, and cytoskeletal dynamics. Its dysregulation has been implicated in various diseases, including muscular dystrophy, cardiac disease, and neurological disorders. Further research is necessary to fully elucidate the functional significance of the MYH13 gene and its potential therapeutic applications.

Genular Protein ID: 310359327

Symbol: MYH13_HUMAN

Name: Myosin-13

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 10388558

Title: Comparative sequence analysis of the complete human sarcomeric myosin heavy chain family: implications for functional diversity.

PubMed ID: 10388558

DOI: 10.1006/jmbi.1999.2865

PubMed ID: 16625196

Title: DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage.

PubMed ID: 16625196

DOI: 10.1038/nature04689

PubMed ID: 11032345

Title: Human skeletal myosin heavy chain genes are tightly linked in the order embryonic-IIa-IId/x-ILb-perinatal-extraocular.

PubMed ID: 11032345

DOI: 10.1023/a:1005635030494

PubMed ID: 9806854

Title: The human extraocular muscle myosin heavy chain gene (MYH13) maps to the cluster of fast and developmental myosin genes on chromosome 17.

PubMed ID: 9806854

DOI: 10.1006/geno.1998.5558

PubMed ID: 12110653

Title: Phylogenetic implications of the superfast myosin in extraocular muscles.

PubMed ID: 12110653

DOI: 10.1242/jeb.205.15.2189

PubMed ID: 23908353

Title: The superfast human extraocular myosin is kinetically distinct from the fast skeletal IIa, IIb, and IId isoforms.

PubMed ID: 23908353

DOI: 10.1074/jbc.m113.488130

Sequence Information:

  • Length: 1938
  • Mass: 223605
  • Checksum: 66DD43A84F5D38DA
  • Sequence:
  • MSSDAEMAIF GEAAPYLRKP EKERIEAQNR PFDSKKACFV ADNKEMYVKG MIQTRENDKV 
    IVKTLDDRML TLNNDQVFPM NPPKFDKIED MAMMTHLHEP AVLYNLKERY AAWMIYTYSG 
    LFCVTVNPYK WLPVYKPEVV AAYRGKKRQE APPHIFSISD NAYQFMLTDR DNQSILITGE 
    SGAGKTVNTK RVIQYFATIA VTGDKKKETQ PGKMQGTLED QIIQANPLLE AFGNAKTVRN 
    DNSSRFGKFI RIHFGATGKL ASADIETYLL EKSRVTFQLS SERSYHIFYQ IMSNKKPELI 
    DLLLISTNPF DFPFVSQGEV TVASIDDSEE LLATDNAIDI LGFSSEEKVG IYKLTGAVMH 
    YGNMKFKQKQ REEQAEPDGT EVADKAGYLM GLNSAEMLKG LCCPRVKVGN EYVTKGQNVQ 
    QVTNSVGALA KAVYEKMFLW MVTRINQQLD TKQPRQYFIG VLDIAGFEIF DFNSLEQLCI 
    NFTNEKLQQF FNHHMFVLEQ EEYKKEGIEW EFIDFGMDLA ACIELIEKPM GIFSILEEEC 
    MFPKATDTSF KNKLYDQHLG KSNNFQKPKP AKGKAEAHFS LVHYAGTVDY NIAGWLDKNK 
    DPLNETVVGL YQKSSLKLLS FLFSNYAGAE TGDSGGSKKG GKKKGSSFQT VSAVFRENLN 
    KLMTNLRSTH PHFVRCLIPN ETKTPGVMDH YLVMHQLRCN GVLEGIRICR KGFPSRILYA 
    DFKQRYRILN ASAIPEGQFI DSKNASEKLL NSIDVDREQF RFGNTKVFFK AGLLGLLEEM 
    RDEKLVTLMT STQAVCRGYL MRVEFKKMME RRDSIFCIQY NIRSFMNVKH WPWMNLFFKI 
    KPLLKSAEAE KEMATMKEDF ERTKEELARS EARRKELEEK MVSLLQEKND LQLQVQSETE 
    NLMDAEERCE GLIKSKILLE AKVKELTERL EEEEEMNSEL VAKKRNLEDK CSSLKRDIDD 
    LELTLTKVEK EKHATENKVK NLSEEMTALE ENISKLTKEK KSLQEAHQQT LDDLQVEEDK 
    VNGLIKINAK LEQQTDDLEG SLEQEKKLRA DLERAKRKLE GDLKMSQESI MDLENDKQQI 
    EEKLKKKEFE LSQLQAKIDD EQVHSLQFQK KIKELQARIE ELEEEIEAEH TLRAKIEKQR 
    SDLARELEEI SERLEEASGA TSAQIEMNKK REAEFQKMRR DLEEATLQHE ATAATLRKKQ 
    ADSVAELGEQ IDNLQRVKQK LEKEKSELKM EIDDMASNIE ALSKSKSNIE RTCRTVEDQF 
    SEIKAKDEQQ TQLIHDLNMQ KARLQTQNGE LSHRVEEKES LISQLTKSKQ ALTQQLEELK 
    RQMEEETKAK NAMAHALQSS RHDCDLLREQ YEEEQEAKAE LQRALSKANS EVAQWRTKYE 
    TDAIQRTEEL EEAKKKLAQR LQEAEENTET ANSKCASLEK TKQRLQGEVE DLMRDLERSH 
    TACATLDKKQ RNFDKVLAEW KQKLDESQAE LEAAQKESRS LSTELFKMRN AYEEVVDQLE 
    TLRRENKNLQ EEISDLTEQI AETGKNLQEA EKTKKLVEQE KSDLQVALEE VEGSLEHEES 
    KILRVQLELS QVKSELDRKV IEKDEEIEQL KRNSQRAAEA LQSVLDAEIR SRNDALRLKK 
    KMEGDLNEME IQLGHSNRQM AETQKHLRTV QGQLKDSQLH LDDALRSNED LKEQLAIVER 
    RNGLLLEELE EMKVALEQTE RTRRLSEQEL LDASDRVQLL HSQNTSLINT KKKLEADIAQ 
    CQAEVENSIQ ESRNAEEKAK KAITDAAMMA EELKKEQDTS AHLERMKKNL EQTVKDLQHR 
    LDEAEQLALK GGKKQIQKLE NRVRELENEL DVEQKRGAEA LKGAHKYERK VKEMTYQAEE 
    DHKNILRLQD LVDKLQAKVK SYKRQAEEAE EQANTQLSRC RRVQHELEEA AERADIAESQ 
    VNKLRAKSRD VGSQKMEE

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.