Details for: VIPR2

Gene ID: 7434

Symbol: VIPR2

Ensembl ID: ENSG00000106018

Description: vasoactive intestinal peptide receptor 2

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 63.0685
    Cell Significance Index: -9.8100
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 19.2535
    Cell Significance Index: -9.0900
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 15.5751
    Cell Significance Index: -6.3300
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 7.9970
    Cell Significance Index: -9.8600
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 2.1335
    Cell Significance Index: 163.7300
  • Cell Name: myometrial cell (CL0002366)
    Fold Change: 1.0458
    Cell Significance Index: 12.0500
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 1.0117
    Cell Significance Index: 12.0600
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.9626
    Cell Significance Index: 60.6700
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: 0.9371
    Cell Significance Index: 10.2500
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 0.9287
    Cell Significance Index: 14.9000
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.3719
    Cell Significance Index: 5.3400
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.3163
    Cell Significance Index: 17.7500
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.2474
    Cell Significance Index: 33.9800
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: 0.2405
    Cell Significance Index: 3.5500
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.1955
    Cell Significance Index: 70.1100
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 0.1875
    Cell Significance Index: 3.9300
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.1855
    Cell Significance Index: 37.2100
  • Cell Name: Mueller cell (CL0000636)
    Fold Change: 0.1430
    Cell Significance Index: 1.1000
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.1405
    Cell Significance Index: 63.7900
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.1380
    Cell Significance Index: 95.4200
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.0865
    Cell Significance Index: 14.7800
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0781
    Cell Significance Index: 49.5900
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0757
    Cell Significance Index: 142.6000
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.0335
    Cell Significance Index: 2.1600
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 0.0098
    Cell Significance Index: 1.4300
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 0.0082
    Cell Significance Index: 0.2100
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: 0.0041
    Cell Significance Index: 0.0800
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0011
    Cell Significance Index: -0.1900
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.0031
    Cell Significance Index: -0.0900
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0049
    Cell Significance Index: -9.0900
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0056
    Cell Significance Index: -8.6800
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0070
    Cell Significance Index: -9.4700
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0099
    Cell Significance Index: -7.2500
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0132
    Cell Significance Index: -10.0100
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0143
    Cell Significance Index: -10.5900
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0162
    Cell Significance Index: -10.1100
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0170
    Cell Significance Index: -9.3000
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0182
    Cell Significance Index: -10.2800
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0271
    Cell Significance Index: -7.7900
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0378
    Cell Significance Index: -4.6500
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0386
    Cell Significance Index: -7.6700
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0402
    Cell Significance Index: -2.4700
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0505
    Cell Significance Index: -10.6300
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0560
    Cell Significance Index: -2.8300
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0571
    Cell Significance Index: -0.9600
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.0594
    Cell Significance Index: -0.8500
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0601
    Cell Significance Index: -7.7000
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0605
    Cell Significance Index: -7.8100
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0664
    Cell Significance Index: -6.7800
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0665
    Cell Significance Index: -6.9200
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0680
    Cell Significance Index: -7.7900
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0684
    Cell Significance Index: -7.9700
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0708
    Cell Significance Index: -8.3500
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.0712
    Cell Significance Index: -1.4300
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: -0.0912
    Cell Significance Index: -1.1700
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0939
    Cell Significance Index: -7.0000
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.1040
    Cell Significance Index: -2.5200
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.1080
    Cell Significance Index: -2.5900
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.1185
    Cell Significance Index: -5.5700
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.1216
    Cell Significance Index: -6.3400
  • Cell Name: L4 intratelencephalic projecting glutamatergic neuron (CL4030063)
    Fold Change: -0.1286
    Cell Significance Index: -1.4100
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.1328
    Cell Significance Index: -8.9300
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: -0.1418
    Cell Significance Index: -3.4600
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: -0.1443
    Cell Significance Index: -1.7900
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.1461
    Cell Significance Index: -7.6700
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.1513
    Cell Significance Index: -7.8600
  • Cell Name: keratocyte (CL0002363)
    Fold Change: -0.1633
    Cell Significance Index: -2.5900
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.1797
    Cell Significance Index: -4.8900
  • Cell Name: L6 corticothalamic-projecting glutamatergic cortical neuron (CL4023042)
    Fold Change: -0.1813
    Cell Significance Index: -2.0000
  • Cell Name: mesodermal cell (CL0000222)
    Fold Change: -0.1869
    Cell Significance Index: -1.1700
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.1882
    Cell Significance Index: -8.5300
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.1902
    Cell Significance Index: -6.6100
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.2014
    Cell Significance Index: -8.9100
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.2113
    Cell Significance Index: -5.2700
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: -0.2224
    Cell Significance Index: -1.8900
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -0.2241
    Cell Significance Index: -4.7900
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.2246
    Cell Significance Index: -10.4700
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.2254
    Cell Significance Index: -6.6400
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.2287
    Cell Significance Index: -6.3900
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.2375
    Cell Significance Index: -8.3200
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.2390
    Cell Significance Index: -9.0500
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: -0.2442
    Cell Significance Index: -6.0900
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.2660
    Cell Significance Index: -8.7100
  • Cell Name: L2/3 intratelencephalic projecting glutamatergic neuron (CL4030059)
    Fold Change: -0.2678
    Cell Significance Index: -3.5700
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.2698
    Cell Significance Index: -5.8300
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.2772
    Cell Significance Index: -7.4200
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: -0.2773
    Cell Significance Index: -4.2900
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.2806
    Cell Significance Index: -8.2400
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.2820
    Cell Significance Index: -8.9800
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.2855
    Cell Significance Index: -10.4800
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: -0.2877
    Cell Significance Index: -3.8800
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.2908
    Cell Significance Index: -6.0700
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.2911
    Cell Significance Index: -10.2300
  • Cell Name: thymocyte (CL0000893)
    Fold Change: -0.3015
    Cell Significance Index: -3.8100
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: -0.3050
    Cell Significance Index: -3.9800
  • Cell Name: photoreceptor cell (CL0000210)
    Fold Change: -0.3076
    Cell Significance Index: -4.3200
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.3110
    Cell Significance Index: -6.6000
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.3164
    Cell Significance Index: -9.0300
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: -0.3193
    Cell Significance Index: -10.1000
  • Cell Name: basal epithelial cell of prostatic duct (CL0002236)
    Fold Change: -0.3267
    Cell Significance Index: -2.9000

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** VIPR2 is a GPCR that exhibits a high degree of specificity for VIP, a peptide hormone that plays a crucial role in various physiological processes. The receptor is characterized by its unique structure, which includes a large extracellular loop and a long intracellular tail. This structure allows VIPR2 to interact with various signaling molecules, including G proteins, phospholipase C, and protein kinase A. The receptor is also known for its ability to modulate adenylate cyclase activity, which is a key step in the VIP signaling pathway. **Pathways and Functions** VIPR2 is involved in several signaling pathways, including: 1. **Adenylate cyclase-modulating G protein-coupled receptor signaling pathway**: VIPR2 modulates adenylate cyclase activity, which is a key step in the VIP signaling pathway. This pathway is involved in smooth muscle relaxation, cell proliferation, and immune responses. 2. **Cell-cell signaling**: VIPR2 is expressed in various cell types, including cardiac, smooth muscle, and immune cells. It plays a crucial role in cell-cell communication, modulating the behavior of these cells in response to VIP. 3. **G alpha (s) signalling events**: VIPR2 is coupled to Gs proteins, which activate adenylate cyclase and increase cAMP levels. This pathway is involved in smooth muscle relaxation and cell proliferation. 4. **Negative regulation of smooth muscle cell proliferation**: VIPR2 has been shown to inhibit smooth muscle cell proliferation, which is a key step in the development of various diseases, including cardiovascular disease and cancer. **Clinical Significance** VIPR2 has been implicated in various diseases, including: 1. **Cardiovascular disease**: VIPR2 is involved in the regulation of smooth muscle cell proliferation, which is a key step in the development of cardiovascular disease. Alterations in VIPR2 expression or function have been linked to the development of hypertension and atherosclerosis. 2. **Cancer**: VIPR2 has been shown to inhibit smooth muscle cell proliferation, which is a key step in the development of cancer. Alterations in VIPR2 expression or function have been linked to the development of various cancers, including colorectal and breast cancer. 3. **Immune responses**: VIPR2 is expressed in various immune cells, including dendritic cells and T cells. It plays a crucial role in modulating immune responses, including the regulation of inflammation and immune cell activation. In conclusion, VIPR2 is a key receptor that plays a crucial role in various physiological processes, including cell signaling, smooth muscle regulation, and immune responses. Its dysregulation has been implicated in various diseases, including cardiovascular disease, cancer, and immune disorders. Further research is needed to fully understand the mechanisms of VIPR2 and its role in human disease.

Genular Protein ID: 995445465

Symbol: VIPR2_HUMAN

Name: Vasoactive intestinal polypeptide receptor 2

UniProtKB Accession Codes:

P41587 Q13053 Q15870 Q53Y09 Q6ZN22 Q9UCW0

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 1 CTD 1 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 21 EMDB 2 Ensembl 2 EvolutionaryTrace 1 ExpressionAtlas 1 GO 10 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 GuidetoPHARMACOLOGY 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 9 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 3 PDBsum 3 PIR 1 PRINTS 3 PRO 1 PROSITE 4 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 RNAct 1 Reactome 2 RefSeq 3 SMART 1 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 7811244

Title: Molecular cloning and functional characterization of a human VIP receptor from SUP-T1 lymphoblasts.

PubMed ID: 7811244

DOI: 10.1006/bbrc.1994.2852

PubMed ID: 8938447

Title: Chromosomal localization in mouse and human of the vasoactive intestinal peptide receptor type 2 gene: a possible contributor to the holoprosencephaly 3 phenotype.

PubMed ID: 8938447

DOI: 10.1006/geno.1996.0569

PubMed ID: 8933357

Title: Tissue specific expression of different human receptor types for pituitary adenylate cyclase activating polypeptide and vasoactive intestinal polypeptide: implications for their role in human physiology.

PubMed ID: 8933357

DOI: 10.1046/j.1365-2826.1996.05191.x

PubMed ID: 10481065

Title: Structure of the human VIP2R gene for vasoactive intestinal peptide type 2 receptor.

PubMed ID: 10481065

DOI: 10.1016/s0014-5793(99)01135-7

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 12853948

Title: The DNA sequence of human chromosome 7.

PubMed ID: 12853948

DOI: 10.1038/nature01782

PubMed ID: 12690205

Title: Human chromosome 7: DNA sequence and biology.

PubMed ID: 12690205

DOI: 10.1126/science.1083423

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8926282

Title: Predominant expression of type II vasoactive intestinal peptide receptors by human T lymphoblastoma cells: transduction of both Ca2+ and cyclic AMP signals.

PubMed ID: 8926282

DOI: 10.1007/bf01540969

Sequence Information:

  • Length: 438
  • Mass: 49479
  • Checksum: 265A43A70BE09699
  • Sequence:
    • MRTLLPPALL TCWLLAPVNS IHPECRFHLE IQEEETKCAE LLRSQTEKHK ACSGVWDNIT 
CWRPANVGET VTVPCPKVFS NFYSKAGNIS KNCTSDGWSE TFPDFVDACG YSDPEDESKI 
TFYILVKAIY TLGYSVSLMS LATGSIILCL FRKLHCTRNY IHLNLFLSFI LRAISVLVKD 
DVLYSSSGTL HCPDQPSSWV GCKLSLVFLQ YCIMANFFWL LVEGLYLHTL LVAMLPPRRC 
FLAYLLIGWG LPTVCIGAWT AARLYLEDTG CWDTNDHSVP WWVIRIPILI SIIVNFVLFI 
SIIRILLQKL TSPDVGGNDQ SQYKRLAKST LLLIPLFGVH YMVFAVFPIS ISSKYQILFE 
LCLGSFQGLV VAVLYCFLNS EVQCELKRKW RSRCPTPSAS RDYRVCGSSF SRNGSEGALQ 
FHRGSRAQSF LQTETSVI

Genular Protein ID: 153474536

Symbol: X5DP12_HUMAN

Name: N/A

UniProtKB Accession Codes:

X5DP12

Database IDs:

ARBA 11 AlphaFoldDB 1 BioGRID-ORCS 1 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 2 GO 6 Gene3D 1 InterPro 8 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PRINTS 3 PROSITE 6 PeptideAtlas 1 Pfam 2 RefSeq 1 SAM 2 SMART 1 SMR 1 SUPFAM 2

Citations:

PubMed ID: 24722188

Title: Protein interaction network of alternatively spliced isoforms from brain links genetic risk factors for autism.

PubMed ID: 24722188

Sequence Information:

  • Length: 358
  • Mass: 40454
  • Checksum: 5E25719ADE1BD7C6
  • Sequence:
    • MRTLLPPALL TCWLLAPVNS IHPECRFHLE IQEEETKCAE LLRSQTEKHK ACSGVWDNIT 
CWRPANVGET VTVPCPKVFS NFYSKAGNIS KNCTSDGWSE TFPDFVDACG YSDPEDESKV 
GCKLSLVFLQ YCIMANFFWL LVEGLYLHTL LVAMLPPRRC FLAYLLIGWG LPTVCIGAWT 
AARLYLEDTG CWDTNDHSVP WWVIRIPILI SIIVNFVLFI SIIRILLQKL TSPDVGGNDQ 
SQYKRLAKST LLLIPLFGVH YMVFAVFPIS ISSKYQILFE LCLGSFQGLV VAVLYCFLNS 
EVQCELKRKW RSRCPTPSAS RDYRVCGSSF SRNGSEGALQ FHRGSRAQSF LQTETSVI

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.