Details for: GPR37

Gene ID: 2861

Symbol: GPR37

Ensembl ID: ENSG00000170775

Description: G protein-coupled receptor 37

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 26.5595
    Cell Significance Index: -10.7900
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 3.2401
    Cell Significance Index: 198.6500
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: 1.4200
    Cell Significance Index: 23.4000
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 1.0628
    Cell Significance Index: 202.2600
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.5203
    Cell Significance Index: 469.7900
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.4687
    Cell Significance Index: 60.0800
  • Cell Name: retinal bipolar neuron (CL0000748)
    Fold Change: 0.4455
    Cell Significance Index: 5.4000
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: 0.3893
    Cell Significance Index: 9.4300
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.3047
    Cell Significance Index: 49.5600
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.2448
    Cell Significance Index: 26.6200
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.1369
    Cell Significance Index: 2.9200
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.1238
    Cell Significance Index: 24.8400
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.0856
    Cell Significance Index: 5.9200
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.0673
    Cell Significance Index: 4.0400
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.0670
    Cell Significance Index: 6.6300
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.0513
    Cell Significance Index: 0.7000
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.0504
    Cell Significance Index: 2.8300
  • Cell Name: Mueller cell (CL0000636)
    Fold Change: 0.0494
    Cell Significance Index: 0.3800
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.0489
    Cell Significance Index: 21.6300
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.0339
    Cell Significance Index: 6.7300
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0270
    Cell Significance Index: 0.9500
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.0175
    Cell Significance Index: 0.4700
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 0.0129
    Cell Significance Index: 0.8700
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.0095
    Cell Significance Index: 0.4300
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.0046
    Cell Significance Index: 0.1000
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 0.0018
    Cell Significance Index: 0.2100
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0005
    Cell Significance Index: -0.0600
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0025
    Cell Significance Index: -4.6500
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0067
    Cell Significance Index: -0.1800
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0077
    Cell Significance Index: -0.3600
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0082
    Cell Significance Index: -2.9500
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: -0.0083
    Cell Significance Index: -5.7700
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.0087
    Cell Significance Index: -0.2500
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0124
    Cell Significance Index: -1.8000
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0132
    Cell Significance Index: -9.7500
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: -0.0140
    Cell Significance Index: -0.1500
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0156
    Cell Significance Index: -11.8000
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0163
    Cell Significance Index: -11.9700
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0171
    Cell Significance Index: -10.8500
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0173
    Cell Significance Index: -9.4600
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.0180
    Cell Significance Index: -0.4500
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0196
    Cell Significance Index: -11.0800
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0204
    Cell Significance Index: -9.2600
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0285
    Cell Significance Index: -8.1900
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.0392
    Cell Significance Index: -1.1200
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.0402
    Cell Significance Index: -2.1100
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0467
    Cell Significance Index: -4.7700
  • Cell Name: keratocyte (CL0002363)
    Fold Change: -0.0536
    Cell Significance Index: -0.8500
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0538
    Cell Significance Index: -9.7000
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0546
    Cell Significance Index: -9.3300
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0568
    Cell Significance Index: -11.9700
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0570
    Cell Significance Index: -7.3600
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.0671
    Cell Significance Index: -4.2300
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0746
    Cell Significance Index: -9.1700
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0813
    Cell Significance Index: -11.1700
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0969
    Cell Significance Index: -7.2200
  • Cell Name: rod bipolar cell (CL0000751)
    Fold Change: -0.1003
    Cell Significance Index: -1.1500
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.1090
    Cell Significance Index: -7.7100
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1128
    Cell Significance Index: -11.7400
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: -0.1139
    Cell Significance Index: -0.9400
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.1146
    Cell Significance Index: -3.6700
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.1192
    Cell Significance Index: -6.1900
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.1249
    Cell Significance Index: -3.4900
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.1461
    Cell Significance Index: -3.0300
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.1591
    Cell Significance Index: -9.7800
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: -0.1647
    Cell Significance Index: -2.3100
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.1728
    Cell Significance Index: -2.0600
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.1739
    Cell Significance Index: -2.9100
  • Cell Name: ON-bipolar cell (CL0000749)
    Fold Change: -0.1797
    Cell Significance Index: -2.0300
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.1889
    Cell Significance Index: -8.8800
  • Cell Name: granule cell (CL0000120)
    Fold Change: -0.1924
    Cell Significance Index: -2.1900
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.2035
    Cell Significance Index: -10.6000
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.2037
    Cell Significance Index: -3.0700
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.2082
    Cell Significance Index: -6.8200
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.2330
    Cell Significance Index: -7.4200
  • Cell Name: macroglial cell (CL0000126)
    Fold Change: -0.2375
    Cell Significance Index: -2.7500
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.2391
    Cell Significance Index: -9.8000
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.2420
    Cell Significance Index: -5.5900
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.2445
    Cell Significance Index: -6.4300
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.2457
    Cell Significance Index: -5.3800
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.2496
    Cell Significance Index: -11.0400
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.2749
    Cell Significance Index: -10.0900
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.2815
    Cell Significance Index: -9.8600
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.2862
    Cell Significance Index: -7.1400
  • Cell Name: midget ganglion cell of retina (CL4023188)
    Fold Change: -0.2909
    Cell Significance Index: -3.0300
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.3042
    Cell Significance Index: -11.5200
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.3237
    Cell Significance Index: -8.3200
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: -0.3329
    Cell Significance Index: -5.6900
  • Cell Name: neural cell (CL0002319)
    Fold Change: -0.3377
    Cell Significance Index: -3.9400
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.3473
    Cell Significance Index: -12.0700
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: -0.3688
    Cell Significance Index: -5.2500
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.3828
    Cell Significance Index: -10.4200
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.3901
    Cell Significance Index: -10.4400
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.3982
    Cell Significance Index: -7.7900
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.4034
    Cell Significance Index: -11.5700
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.4069
    Cell Significance Index: -20.5600
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.4081
    Cell Significance Index: -12.0200
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.4231
    Cell Significance Index: -10.7800
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -0.4245
    Cell Significance Index: -7.3400
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.4268
    Cell Significance Index: -10.6600

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** GPR37 is a member of the class A/1 GPCR family, characterized by its rhodopsin-like structure. It is expressed in a wide range of cells, including oligodendrocytes, Mueller cells, conventional dendritic cells, rod bipolar cells, granulocyte monocyte progenitor cells, enterocytes, cerebral cortex GABAergic interneurons, forebrain radial glial cells, intestinal crypt stem cells, and absorptive cells. The receptor's ligand-binding properties are distinct, with a preference for peptide ligands. Notably, GPR37 is also associated with heat shock proteins, such as Hsp70, which may play a role in its stability and function. **Pathways and Functions:** GPR37 is involved in several signaling pathways, including: 1. **Adenylate cyclase-inhibiting GPCR signaling pathway**: GPR37 modulates the activity of adenylate cyclase, a key enzyme in GPCR signaling. 2. **Cell surface and cytoplasmic signaling**: GPR37 interacts with various signaling molecules, including Gαi proteins, to regulate cell surface and cytoplasmic signaling. 3. **Dendrite development and locomotory behavior**: GPR37 plays a role in regulating dendrite development and locomotory behavior, suggesting its involvement in neural circuitry and motor function. 4. **Dopamine biosynthetic process**: GPR37 modulates dopamine biosynthesis, which is crucial for neurotransmission and behavior regulation. 5. **MAPK cascade regulation**: GPR37 regulates the MAPK cascade, a key signaling pathway involved in cell proliferation, differentiation, and survival. **Clinical Significance:** GPR37's involvement in dopamine biosynthesis, locomotory behavior, and MAPK cascade regulation raises important questions about its potential role in neurological disorders. Research has shown that GPR37 is dysregulated in various diseases, including: 1. **Neurodegenerative disorders**: GPR37 may contribute to the pathogenesis of neurodegenerative diseases, such as Parkinson's disease and Huntington's disease. 2. **Mental health disorders**: GPR37's involvement in dopamine biosynthesis and MAPK cascade regulation may also contribute to the development of mental health disorders, such as schizophrenia and bipolar disorder. 3. **Cancer**: GPR37's expression in various cancer types, including granulocyte monocyte progenitor cells, suggests its potential role in cancer development and progression. In conclusion, GPR37 is a multifaceted GPCR with diverse expression patterns and involvement in multiple signaling pathways. Further research is needed to elucidate the complex functions of GPR37 and its potential role in neurological and psychiatric disorders.

Genular Protein ID: 1438920412

Symbol: GPR37_HUMAN

Name: Prosaposin receptor GPR37

UniProtKB Accession Codes:

O15354 A4D0Y6 O00348 O14768 Q8TD39

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChEMBL 1 ChiTaRS 1 DIP 1 DNASU 1 DisGeNET 1 EMBL 9 Ensembl 1 GO 28 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 GuidetoPHARMACOLOGY 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 1 PRINTS 2 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 2 RefSeq 1 SIGNOR 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TCDB 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9339362

Title: Cloning of GPR37, a gene located on chromosome 7 encoding a putative G-protein-coupled peptide receptor, from a human frontal brain EST library.

PubMed ID: 9339362

DOI: 10.1006/geno.1997.4900

PubMed ID: 9526070

Title: A human gene encodes a putative G protein-coupled receptor highly expressed in the central nervous system.

PubMed ID: 9526070

DOI: 10.1016/s0169-328x(97)00336-7

PubMed ID: 9144577

Title: A novel endothelin receptor type-B-like gene enriched in the brain.

PubMed ID: 9144577

DOI: 10.1006/bbrc.1997.6408

PubMed ID: 11439185

Title: An unfolded putative transmembrane polypeptide, which can lead to endoplasmic reticulum stress, is a substrate of Parkin.

PubMed ID: 11439185

DOI: 10.1016/s0092-8674(01)00407-x

PubMed ID: 12853948

Title: The DNA sequence of human chromosome 7.

PubMed ID: 12853948

DOI: 10.1038/nature01782

PubMed ID: 12690205

Title: Human chromosome 7: DNA sequence and biology.

PubMed ID: 12690205

DOI: 10.1126/science.1083423

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 12150907

Title: CHIP is associated with Parkin, a gene responsible for familial Parkinson's disease, and enhances its ubiquitin ligase activity.

PubMed ID: 12150907

DOI: 10.1016/s1097-2765(02)00583-x

PubMed ID: 14532270

Title: A product of the human gene adjacent to parkin is a component of Lewy bodies and suppresses Pael receptor-induced cell death.

PubMed ID: 14532270

DOI: 10.1074/jbc.m309655200

PubMed ID: 17059562

Title: A ubiquitin ligase HRD1 promotes the degradation of Pael receptor, a substrate of Parkin.

PubMed ID: 17059562

DOI: 10.1111/j.1471-4159.2006.04155.x

PubMed ID: 23690594

Title: GPR37 and GPR37L1 are receptors for the neuroprotective and glioprotective factors prosaptide and prosaposin.

PubMed ID: 23690594

DOI: 10.1073/pnas.1219004110

PubMed ID: 25977097

Title: CASPR2 forms a complex with GPR37 via MUPP1 but not with GPR37(R558Q), an autism spectrum disorder-related mutation.

PubMed ID: 25977097

DOI: 10.1111/jnc.13168

PubMed ID: 26869225

Title: The Parkinson's-disease-associated receptor GPR37 undergoes metalloproteinase-mediated N-terminal cleavage and ectodomain shedding.

PubMed ID: 26869225

DOI: 10.1242/jcs.176115

PubMed ID: 28341812

Title: Parkinson's disease-associated receptor GPR37 is an ER chaperone for LRP6.

PubMed ID: 28341812

DOI: 10.15252/embr.201643585

PubMed ID: 34042202

Title: GPR37 is processed in the N-terminal ectodomain by ADAM10 and furin.

PubMed ID: 34042202

DOI: 10.1096/fj.202002385rr

Sequence Information:

  • Length: 613
  • Mass: 67114
  • Checksum: 5A1AB269ED63E765
  • Sequence:
    • MRAPGALLAR MSRLLLLLLL KVSASSALGV APASRNETCL GESCAPTVIQ RRGRDAWGPG 
NSARDVLRAR APREEQGAAF LAGPSWDLPA APGRDPAAGR GAEASAAGPP GPPTRPPGPW 
RWKGARGQEP SETLGRGNPT ALQLFLQISE EEEKGPRGAG ISGRSQEQSV KTVPGASDLF 
YWPRRAGKLQ GSHHKPLSKT ANGLAGHEGW TIALPGRALA QNGSLGEGIH EPGGPRRGNS 
TNRRVRLKNP FYPLTQESYG AYAVMCLSVV IFGTGIIGNL AVMCIVCHNY YMRSISNSLL 
ANLAFWDFLI IFFCLPLVIF HELTKKWLLE DFSCKIVPYI EVASLGVTTF TLCALCIDRF 
RAATNVQMYY EMIENCSSTT AKLAVIWVGA LLLALPEVVL RQLSKEDLGF SGRAPAERCI 
IKISPDLPDT IYVLALTYDS ARLWWYFGCY FCLPTLFTIT CSLVTARKIR KAEKACTRGN 
KRQIQLESQM NCTVVALTIL YGFCIIPENI CNIVTAYMAT GVSQQTMDLL NIISQFLLFF 
KSCVTPVLLF CLCKPFSRAF MECCCCCCEE CIQKSSTVTS DDNDNEYTTE LELSPFSTIR 
REMSTFASVG THC

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.