Details for: GPR37

Gene ID: 2861

Symbol: GPR37

Ensembl ID: ENSG00000170775

Description: G protein-coupled receptor 37

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: 2.65
    Marker Score: 6338
  • Cell Name: Mueller cell (CL0000636)
    Fold Change: 2.39
    Marker Score: 3313.5
  • Cell Name: conventional dendritic cell (CL0000990)
    Fold Change: 2.19
    Marker Score: 1507
  • Cell Name: rod bipolar cell (CL0000751)
    Fold Change: 2.03
    Marker Score: 1059.5
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 1.37
    Marker Score: 866
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 1.15
    Marker Score: 4808
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71818
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48043
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.99
    Marker Score: 668
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30407
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.98
    Marker Score: 505
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.97
    Marker Score: 459
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.95
    Marker Score: 394.5
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2412
  • Cell Name: respiratory basal cell (CL0002633)
    Fold Change: 0.94
    Marker Score: 1354
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.93
    Marker Score: 5330
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2736
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.9
    Marker Score: 323
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5283
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.8
    Marker Score: 611
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.79
    Marker Score: 315
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1259
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.77
    Marker Score: 706
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.76
    Marker Score: 393
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.69
    Marker Score: 177
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.68
    Marker Score: 1297.5
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.68
    Marker Score: 1150.5
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.64
    Marker Score: 1297
  • Cell Name: pulmonary interstitial fibroblast (CL0002241)
    Fold Change: 0.61
    Marker Score: 485
  • Cell Name: macroglial cell (CL0000126)
    Fold Change: 0.59
    Marker Score: 1366
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.59
    Marker Score: 379
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.56
    Marker Score: 444
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.56
    Marker Score: 368
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.55
    Marker Score: 146
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.52
    Marker Score: 311
  • Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
    Fold Change: 0.5
    Marker Score: 1027
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 0.49
    Marker Score: 511
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: 0.49
    Marker Score: 472
  • Cell Name: cell of skeletal muscle (CL0000188)
    Fold Change: 0.49
    Marker Score: 370
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.48
    Marker Score: 7469
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: 0.46
    Marker Score: 2708
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.44
    Marker Score: 248
  • Cell Name: oocyte (CL0000023)
    Fold Change: 0.43
    Marker Score: 107
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 0.42
    Marker Score: 3957
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.41
    Marker Score: 190
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 0.38
    Marker Score: 3236
  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.37
    Marker Score: 216
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 0.37
    Marker Score: 368
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: 0.36
    Marker Score: 580
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: 0.36
    Marker Score: 354
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.36
    Marker Score: 113
  • Cell Name: granule cell (CL0000120)
    Fold Change: 0.35
    Marker Score: 2662
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.33
    Marker Score: 241
  • Cell Name: enteric smooth muscle cell (CL0002504)
    Fold Change: 0.33
    Marker Score: 775
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 0.32
    Marker Score: 3024
  • Cell Name: stellate neuron (CL0000122)
    Fold Change: 0.31
    Marker Score: 1670
  • Cell Name: Unknown (CL0002371)
    Fold Change: 0.31
    Marker Score: 329
  • Cell Name: neuron (CL0000540)
    Fold Change: 0.31
    Marker Score: 1258
  • Cell Name: pyramidal neuron (CL0000598)
    Fold Change: 0.29
    Marker Score: 484
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 0.28
    Marker Score: 150
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.28
    Marker Score: 135
  • Cell Name: OFF retinal ganglion cell (CL4023033)
    Fold Change: 0.28
    Marker Score: 118
  • Cell Name: cerebral cortex neuron (CL0010012)
    Fold Change: 0.27
    Marker Score: 767
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: 0.27
    Marker Score: 238
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 0.27
    Marker Score: 231
  • Cell Name: renal principal cell (CL0005009)
    Fold Change: 0.26
    Marker Score: 204
  • Cell Name: malignant cell (CL0001064)
    Fold Change: 0.26
    Marker Score: 3520
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.26
    Marker Score: 109
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.25
    Marker Score: 1002
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.25
    Marker Score: 254
  • Cell Name: mature astrocyte (CL0002627)
    Fold Change: 0.25
    Marker Score: 166
  • Cell Name: retinal pigment epithelial cell (CL0002586)
    Fold Change: 0.24
    Marker Score: 70
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.24
    Marker Score: 141
  • Cell Name: Leydig cell (CL0000178)
    Fold Change: 0.23
    Marker Score: 249
  • Cell Name: microglial cell (CL0000129)
    Fold Change: 0.23
    Marker Score: 415
  • Cell Name: hepatic stellate cell (CL0000632)
    Fold Change: 0.23
    Marker Score: 85
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.22
    Marker Score: 64
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 0.22
    Marker Score: 455
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 0.22
    Marker Score: 4721
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: 0.22
    Marker Score: 77
  • Cell Name: midzonal region hepatocyte (CL0019028)
    Fold Change: 0.22
    Marker Score: 932
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.22
    Marker Score: 73
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: 0.21
    Marker Score: 268
  • Cell Name: interstitial cell of Cajal (CL0002088)
    Fold Change: 0.21
    Marker Score: 73
  • Cell Name: interneuron (CL0000099)
    Fold Change: 0.21
    Marker Score: 95
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.21
    Marker Score: 2066
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.19
    Marker Score: 205
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: 0.19
    Marker Score: 104
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.19
    Marker Score: 85
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 0.19
    Marker Score: 193
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: 0.19
    Marker Score: 234
  • Cell Name: stromal cell (CL0000499)
    Fold Change: 0.19
    Marker Score: 220
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.18
    Marker Score: 11291
  • Cell Name: ON retinal ganglion cell (CL4023032)
    Fold Change: 0.18
    Marker Score: 50
  • Cell Name: glandular epithelial cell (CL0000150)
    Fold Change: 0.18
    Marker Score: 446
  • Cell Name: ovarian surface epithelial cell (CL2000064)
    Fold Change: 0.18
    Marker Score: 486
  • Cell Name: ON-bipolar cell (CL0000749)
    Fold Change: 0.18
    Marker Score: 518
  • Cell Name: tracheal goblet cell (CL1000329)
    Fold Change: 0.18
    Marker Score: 500
  • Cell Name: B cell (CL0000236)
    Fold Change: 0.18
    Marker Score: 167
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.17
    Marker Score: 43

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Other Information

**Key characteristics:** - GPR37 is a G protein-coupled receptor that is expressed in the CNS. - It is a member of the GPCR superfamily, which is known for its involvement in a wide range of cellular processes, including sensory perception, pain sensation, and cognition. - GPR37 is a transmembrane protein that is composed of 14 transmembrane domains. - It has been shown to be a ligand for the neurotransmitter prosaposin. **Pathways and functions:** - GPR37 is a G protein-coupled receptor that is involved in a variety of cellular processes, including sensory perception, pain sensation, and cognition. - It is expressed in the CNS, particularly in neurons and glial cells. - GPR37 is thought to be involved in the transmission of sensory information from the periphery of the CNS to the brain. - It is also involved in the regulation of sleep-wake cycles and pain perception. **Clinical significance:** - Mutations in GPR37 have been linked to several neurological disorders, including autism, schizophrenia, and chronic pain. - These mutations can lead to the loss of GPR37 function, resulting in abnormal sensory perception, pain sensation, and cognitive function. - As a result, targeting GPR37 is a promising therapeutic strategy for these disorders. **Additional notes:** - GPR37 is a relatively new GPCR, with the first crystal structure being solved in 2013. - It is a highly selective GPCR, with only a few known ligands. - The expression of GPR37 is highly regulated, with its expression being influenced by factors such as age, stress, and disease.

Genular Protein ID: 1438920412

Symbol: GPR37_HUMAN

Name: Prosaposin receptor GPR37

UniProtKB Accession Codes:

O15354 A4D0Y6 O00348 O14768 Q8TD39

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChEMBL 1 ChiTaRS 1 DIP 1 DNASU 1 DisGeNET 1 EMBL 9 EPD 1 Ensembl 1 GO 27 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 GuidetoPHARMACOLOGY 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 1 PRINTS 2 PRO 1 PROSITE 1 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 2 RefSeq 1 SAM 1 SIGNOR 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TCDB 1 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9339362

Title: Cloning of GPR37, a gene located on chromosome 7 encoding a putative G-protein-coupled peptide receptor, from a human frontal brain EST library.

PubMed ID: 9339362

DOI: 10.1006/geno.1997.4900

PubMed ID: 9526070

Title: A human gene encodes a putative G protein-coupled receptor highly expressed in the central nervous system.

PubMed ID: 9526070

DOI: 10.1016/s0169-328x(97)00336-7

PubMed ID: 9144577

Title: A novel endothelin receptor type-B-like gene enriched in the brain.

PubMed ID: 9144577

DOI: 10.1006/bbrc.1997.6408

PubMed ID: 11439185

Title: An unfolded putative transmembrane polypeptide, which can lead to endoplasmic reticulum stress, is a substrate of Parkin.

PubMed ID: 11439185

DOI: 10.1016/s0092-8674(01)00407-x

PubMed ID: 12853948

Title: The DNA sequence of human chromosome 7.

PubMed ID: 12853948

DOI: 10.1038/nature01782

PubMed ID: 12690205

Title: Human chromosome 7: DNA sequence and biology.

PubMed ID: 12690205

DOI: 10.1126/science.1083423

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 12150907

Title: CHIP is associated with Parkin, a gene responsible for familial Parkinson's disease, and enhances its ubiquitin ligase activity.

PubMed ID: 12150907

DOI: 10.1016/s1097-2765(02)00583-x

PubMed ID: 14532270

Title: A product of the human gene adjacent to parkin is a component of Lewy bodies and suppresses Pael receptor-induced cell death.

PubMed ID: 14532270

DOI: 10.1074/jbc.m309655200

PubMed ID: 17059562

Title: A ubiquitin ligase HRD1 promotes the degradation of Pael receptor, a substrate of Parkin.

PubMed ID: 17059562

DOI: 10.1111/j.1471-4159.2006.04155.x

PubMed ID: 23690594

Title: GPR37 and GPR37L1 are receptors for the neuroprotective and glioprotective factors prosaptide and prosaposin.

PubMed ID: 23690594

DOI: 10.1073/pnas.1219004110

PubMed ID: 25977097

Title: CASPR2 forms a complex with GPR37 via MUPP1 but not with GPR37(R558Q), an autism spectrum disorder-related mutation.

PubMed ID: 25977097

DOI: 10.1111/jnc.13168

PubMed ID: 26869225

Title: The Parkinson's-disease-associated receptor GPR37 undergoes metalloproteinase-mediated N-terminal cleavage and ectodomain shedding.

PubMed ID: 26869225

DOI: 10.1242/jcs.176115

PubMed ID: 28341812

Title: Parkinson's disease-associated receptor GPR37 is an ER chaperone for LRP6.

PubMed ID: 28341812

DOI: 10.15252/embr.201643585

PubMed ID: 34042202

Title: GPR37 is processed in the N-terminal ectodomain by ADAM10 and furin.

PubMed ID: 34042202

DOI: 10.1096/fj.202002385rr

Sequence Information:

  • Length: 613
  • Mass: 67114
  • Checksum: 5A1AB269ED63E765
  • Sequence:
    • MRAPGALLAR MSRLLLLLLL KVSASSALGV APASRNETCL GESCAPTVIQ RRGRDAWGPG 
NSARDVLRAR APREEQGAAF LAGPSWDLPA APGRDPAAGR GAEASAAGPP GPPTRPPGPW 
RWKGARGQEP SETLGRGNPT ALQLFLQISE EEEKGPRGAG ISGRSQEQSV KTVPGASDLF 
YWPRRAGKLQ GSHHKPLSKT ANGLAGHEGW TIALPGRALA QNGSLGEGIH EPGGPRRGNS 
TNRRVRLKNP FYPLTQESYG AYAVMCLSVV IFGTGIIGNL AVMCIVCHNY YMRSISNSLL 
ANLAFWDFLI IFFCLPLVIF HELTKKWLLE DFSCKIVPYI EVASLGVTTF TLCALCIDRF 
RAATNVQMYY EMIENCSSTT AKLAVIWVGA LLLALPEVVL RQLSKEDLGF SGRAPAERCI 
IKISPDLPDT IYVLALTYDS ARLWWYFGCY FCLPTLFTIT CSLVTARKIR KAEKACTRGN 
KRQIQLESQM NCTVVALTIL YGFCIIPENI CNIVTAYMAT GVSQQTMDLL NIISQFLLFF 
KSCVTPVLLF CLCKPFSRAF MECCCCCCEE CIQKSSTVTS DDNDNEYTTE LELSPFSTIR 
REMSTFASVG THC

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.