Details for: ASH1L

Gene ID: 55870

Gene Type:  Protein-coding  - A gene that serves as a template for producing a messenger RNA (mRNA) molecule, which is then translated into a functional protein.

Symbol: ASH1L

Ensembl ID: ENSG00000116539

Description: ASH1 like histone lysine methyltransferase

Cell Significance Landscape

Associated with

Significant Cells

Cell Significance Index (CSI) scores for the chosen context(s)

  • VIP GABAergic cortical interneuron CL4023016
    CSI 72.52
    rCSI 86.63%
    PRS 10.49
  • sst GABAergic cortical interneuron CL4023017
    CSI 65.8
    rCSI 84.82%
    PRS 11.21
  • pvalb GABAergic cortical interneuron CL4023018
    CSI 60.16
    rCSI 74.84%
    PRS 9.96
  • sncg GABAergic cortical interneuron CL4023015
    CSI 59.3
    rCSI 95.37%
    PRS 11.63
  • lamp5 GABAergic cortical interneuron CL4023011
    CSI 57.43
    rCSI 96.4%
    PRS 10.69
  • caudal ganglionic eminence derived cortical interneuron CL4023064
    CSI 55.07
    rCSI 97.26%
    PRS 10.65
  • adipocyte CL0000136
    CSI 51.1
    rCSI 65.61%
    PRS 17.65
  • cardiac muscle cell CL0000746
    CSI 47.55
    rCSI 68.23%
    PRS 14.02
  • conjunctival epithelial cell CL1000432
    CSI 45.61
    rCSI 69.67%
    PRS 18.23
  • L2/3-6 intratelencephalic projecting glutamatergic neuron CL4023040
    CSI 39.62
    rCSI 96.29%
    PRS 10.49
  • kidney loop of Henle thin descending limb epithelial cell CL1001111
    CSI 37.98
    rCSI 53.84%
    PRS 16.83
  • retinal ganglion cell CL0000740
    CSI 34.7
    rCSI 76.66%
    PRS 12.97
  • L2/3 intratelencephalic projecting glutamatergic neuron CL4030059
    CSI 34.44
    rCSI 74.72%
    PRS 11.88
  • L6b glutamatergic cortical neuron CL4023038
    CSI 30.56
    rCSI 95.52%
    PRS 11.4
  • chandelier pvalb GABAergic cortical interneuron CL4023036
    CSI 28.94
    rCSI 90.52%
    PRS 12.27
  • neuron CL0000540
    CSI 28.18
    rCSI 75.05%
    PRS 14.9
  • retinal pigment epithelial cell CL0002586
    CSI 27.92
    rCSI 55.44%
    PRS 19.14
  • L4 intratelencephalic projecting glutamatergic neuron CL4030063
    CSI 27.71
    rCSI 66.29%
    PRS 11.23
  • keratocyte CL0002363
    CSI 27.29
    rCSI 65.6%
    PRS 26.83
  • L5 extratelencephalic projecting glutamatergic cortical neuron CL4023041
    CSI 26.24
    rCSI 94.44%
    PRS 10.04
  • near-projecting glutamatergic cortical neuron CL4023012
    CSI 24.97
    rCSI 94.37%
    PRS 11
  • transit amplifying cell of colon CL0009011
    CSI 24.26
    rCSI 28.49%
    PRS 21.1
  • GABAergic amacrine cell CL4030027
    CSI 23.61
    rCSI 80.87%
    PRS 15.6
  • small intestine goblet cell CL1000495
    CSI 23.43
    rCSI 51.31%
    PRS 24.28
  • hepatic stellate cell CL0000632
    CSI 21.27
    rCSI 79.69%
    PRS 15.34
  • differentiation-committed oligodendrocyte precursor CL4023059
    CSI 20.09
    rCSI 36.5%
    PRS 15.03
  • astrocyte of the cerebral cortex CL0002605
    CSI 19.53
    rCSI 43.79%
    PRS 11.22
  • BEST4+ enteroycte CL4030026
    CSI 19.24
    rCSI 23.93%
    PRS 19.23
  • L5/6 near-projecting glutamatergic neuron CL4030067
    CSI 18.95
    rCSI 62.27%
    PRS 10.82
  • kidney connecting tubule epithelial cell CL1000768
    CSI 18.89
    rCSI 47.91%
    PRS 13.73
  • epicardial adipocyte CL1000309
    CSI 18.72
    rCSI 60.9%
    PRS 22.02
  • cerebral cortex endothelial cell CL1001602
    CSI 18.52
    rCSI 32.03%
    PRS 13.81
  • corneal epithelial cell CL0000575
    CSI 17.73
    rCSI 50.71%
    PRS 31.9
  • Hofbauer cell CL3000001
    CSI 17.64
    rCSI 33.31%
    PRS 22.84
  • fallopian tube secretory epithelial cell CL4030006
    CSI 16.39
    rCSI 15.77%
    PRS 18.79
  • glutamatergic neuron CL0000679
    CSI 16.06
    rCSI 33.01%
    PRS 17.99
  • intestinal crypt stem cell of small intestine CL0009017
    CSI 16.03
    rCSI 43.21%
    PRS 23.45
  • corticothalamic-projecting glutamatergic cortical neuron CL4023013
    CSI 15.12
    rCSI 89.04%
    PRS 11.22
  • H2 horizontal cell CL0004218
    CSI 14.91
    rCSI 74.14%
    PRS 19.34
  • parietal epithelial cell CL1000452
    CSI 14.76
    rCSI 39.43%
    PRS 15.06
  • S cone cell CL0003050
    CSI 14.57
    rCSI 64.04%
    PRS 15.52
  • rod bipolar cell CL0000751
    CSI 14.55
    rCSI 26.14%
    PRS 15.01
  • H1 horizontal cell CL0004217
    CSI 14.49
    rCSI 57.38%
    PRS 24.58
  • amacrine cell CL0000561
    CSI 13.93
    rCSI 40.37%
    PRS 13.88
  • oligodendrocyte precursor cell CL0002453
    CSI 13.52
    rCSI 29.75%
    PRS 14.37
  • cerebellar granule cell CL0001031
    CSI 13.27
    rCSI 19.51%
    PRS 16.64
  • stromal cell of ovary CL0002132
    CSI 12.78
    rCSI 35.11%
    PRS 29.8
  • retinal bipolar neuron CL0000748
    CSI 12.65
    rCSI 23.69%
    PRS 13.03
  • retinal cone cell CL0000573
    CSI 12.3
    rCSI 19.8%
    PRS 13.89
  • enteroendocrine cell of small intestine CL0009006
    CSI 11.83
    rCSI 26.04%
    PRS 27.58
  • vascular leptomeningeal cell CL4023051
    CSI 11.78
    rCSI 20.65%
    PRS 13.62
  • astrocyte CL0000127
    CSI 11.48
    rCSI 24.45%
    PRS 10.91
  • central nervous system neuron CL2000029
    CSI 11.36
    rCSI 83.52%
    PRS 10.31
  • renal interstitial pericyte CL1001318
    CSI 11.24
    rCSI 30.96%
    PRS 16.76
  • hepatocyte CL0000182
    CSI 11.22
    rCSI 20.07%
    PRS 16.74
  • enterocyte of epithelium of large intestine CL0002071
    CSI 11.2
    rCSI 58.84%
    PRS 31.16
  • brush cell of tracheobronchial tree CL0002075
    CSI 11.06
    rCSI 32.81%
    PRS 25.6
  • paneth cell of epithelium of small intestine CL1000343
    CSI 10.88
    rCSI 30.49%
    PRS 28.06
  • diffuse bipolar 3b cell CL4033030
    CSI 10.82
    rCSI 71.8%
    PRS 18.67
  • hematopoietic precursor cell CL0008001
    CSI 10.79
    rCSI 11.1%
    PRS 29.4
  • endothelial cell of placenta CL0009092
    CSI 10.7
    rCSI 52.72%
    PRS 24.51
  • diffuse bipolar 3a cell CL4033029
    CSI 10.27
    rCSI 69.92%
    PRS 18.6
  • central nervous system macrophage CL0000878
    CSI 9.97
    rCSI 33.06%
    PRS 20.33
  • medium spiny neuron CL1001474
    CSI 9.95
    rCSI 85.7%
    PRS 8.32
  • myeloid dendritic cell CL0000782
    CSI 9.49
    rCSI 13.75%
    PRS 27.14
  • ON-bipolar cell CL0000749
    CSI 9.39
    rCSI 13.95%
    PRS 21.69
  • intermediate monocyte CL0002393
    CSI 8.87
    rCSI 13.38%
    PRS 18.27
  • invaginating midget bipolar cell CL4033034
    CSI 8.71
    rCSI 51.43%
    PRS 18.96
  • basophil CL0000767
    CSI 8.66
    rCSI 18.32%
    PRS 36.23
  • tissue-resident macrophage CL0000864
    CSI 8.5
    rCSI 39.78%
    PRS 36.3
  • flat midget bipolar cell CL4033033
    CSI 8.4
    rCSI 60.07%
    PRS 18.55
  • CD4-positive helper T cell CL0000492
    CSI 8.26
    rCSI 6.25%
    PRS 24.91
  • diffuse bipolar 2 cell CL4033028
    CSI 8.18
    rCSI 63.37%
    PRS 19.19
  • alveolar macrophage CL0000583
    CSI 8.07
    rCSI 13.3%
    PRS 21.41
  • diffuse bipolar 6 cell CL4033032
    CSI 7.82
    rCSI 41.12%
    PRS 20.99
  • glycinergic amacrine cell CL4030028
    CSI 7.78
    rCSI 20.27%
    PRS 17.91
  • transit amplifying cell of small intestine CL0009012
    CSI 7.74
    rCSI 33.96%
    PRS 33.56
  • unswitched memory B cell CL0000970
    CSI 7.59
    rCSI 6.39%
    PRS 28.83
  • mural cell CL0008034
    CSI 7.5
    rCSI 25.41%
    PRS 18.22
  • OFFx cell CL4033036
    CSI 7.43
    rCSI 34.96%
    PRS 19.09
  • microglial cell CL0000129
    CSI 7.31
    rCSI 29.41%
    PRS 38.27
  • pancreatic PP cell CL0002275
    CSI 7.26
    rCSI 28.9%
    PRS 31.3
  • oligodendrocyte CL0000128
    CSI 7.24
    rCSI 21.39%
    PRS 15.32
  • myeloid leukocyte CL0000766
    CSI 7.02
    rCSI 6.48%
    PRS 18.74
  • centrilobular region hepatocyte CL0019029
    CSI 6.92
    rCSI 18.06%
    PRS 27.72
  • inhibitory interneuron CL0000498
    CSI 6.83
    rCSI 15.76%
    PRS 14.63
  • diffuse bipolar 1 cell CL4033027
    CSI 6.81
    rCSI 51.22%
    PRS 17.79
  • neuroblast (sensu Nematoda and Protostomia) CL0000338
    CSI 6.29
    rCSI 7.26%
    PRS 15.89
  • fibroblast of cardiac tissue CL0002548
    CSI 6.17
    rCSI 29.56%
    PRS 13.62
  • alveolar type 1 fibroblast cell CL4028004
    CSI 6.08
    rCSI 6.66%
    PRS 20.51
  • kidney interstitial alternatively activated macrophage CL1000695
    CSI 5.96
    rCSI 15.55%
    PRS 16.66
  • midbrain dopaminergic neuron CL2000097
    CSI 5.91
    rCSI 37.83%
    PRS 27.51
  • starburst amacrine cell CL0004232
    CSI 5.86
    rCSI 49.32%
    PRS 19.2
  • periportal region hepatocyte CL0019026
    CSI 5.8
    rCSI 22.57%
    PRS 24.59
  • ON parasol ganglion cell CL4033052
    CSI 5.75
    rCSI 81.66%
    PRS 13.38
  • extravillous trophoblast CL0008036
    CSI 5.72
    rCSI 7.08%
    PRS 15.88
  • microcirculation associated smooth muscle cell CL0008035
    CSI 5.71
    rCSI 16.52%
    PRS 20.49
  • GABAergic interneuron CL0011005
    CSI 5.69
    rCSI 89.66%
    PRS 14.51
  • GABAergic neuron CL0000617
    CSI 5.51
    rCSI 18.46%
    PRS 12.69
  • podocyte CL0000653
    CSI 5.48
    rCSI 24.34%
    PRS 17.72
  • class switched memory B cell CL0000972
    CSI -5.2
    rCSI -3.9%
    PRS 30.5%
  • peripheral nervous system neuron CL2000032
    CSI -4.0
    rCSI -5.4%
    PRS 16.1%
  • fraction A pre-pro B cell CL0002045
    CSI -3.3
    rCSI -3.8%
    PRS 36.8%
  • enterocyte CL0000584
    CSI -2.9
    rCSI -4.7%
    PRS 28.2%
  • interstitial cell of Cajal CL0002088
    CSI -2.6
    rCSI -3.3%
    PRS 21.1%
  • plasmacytoid dendritic cell, human CL0001058
    CSI -2.0
    rCSI -1.4%
    PRS 19.3%
  • promonocyte CL0000559
    CSI -1.0
    rCSI -1.7%
    PRS 24.6%
  • kidney epithelial cell CL0002518
    CSI -1.0
    rCSI -1.8%
    PRS 40.1%
  • mesodermal cell CL0000222
    CSI -0.8
    rCSI -1.0%
    PRS 17.8%
  • mesenchymal cell CL0008019
    CSI -0.8
    rCSI -2.0%
    PRS 18.3%
  • alternatively activated macrophage CL0000890
    CSI -0.6
    rCSI -0.7%
    PRS 27.9%
  • T-helper 1 cell CL0000545
    CSI -0.6
    rCSI -1.0%
    PRS 44.8%
  • erythroid progenitor cell CL0000038
    CSI -0.4
    rCSI -2.5%
    PRS 27.6%
  • colonocyte CL1000347
    CSI -0.4
    rCSI -0.6%
    PRS 24.7%
  • cytotoxic T cell CL0000910
    CSI -0.1
    rCSI -0.6%
    PRS 26.6%
  • mesenchymal stem cell CL0000134
    CSI 0.1
    rCSI 1.2%
    PRS 32.3%
  • lung microvascular endothelial cell CL2000016
    CSI 0.1
    rCSI 2.2%
    PRS 51.0%
  • late pro-B cell CL0002048
    CSI 0.1
    rCSI 0.3%
    PRS 49.1%
  • epithelial cell of urethra CL1000296
    CSI 0.1
    rCSI 3.3%
    PRS 51.1%
  • tracheal goblet cell CL1000329
    CSI 0.1
    rCSI 0.3%
    PRS 35.4%
  • hair follicular keratinocyte CL2000092
    CSI 0.2
    rCSI 2.7%
    PRS 62.5%
  • lung macrophage CL1001603
    CSI 0.2
    rCSI 0.4%
    PRS 21.0%
  • myeloid dendritic cell, human CL0001057
    CSI 0.2
    rCSI 0.9%
    PRS 53.8%
  • kidney granular cell CL0000648
    CSI 0.2
    rCSI 2.6%
    PRS 66.2%
  • vein endothelial cell of respiratory system CL4033008
    CSI 0.2
    rCSI 1.3%
    PRS 35.0%
  • brush cell CL0002204
    CSI 0.2
    rCSI 0.4%
    PRS 44.3%
  • paneth cell of colon CL0009009
    CSI 0.2
    rCSI 2.3%
    PRS 47.5%
  • enteric neuron CL0007011
    CSI 0.2
    rCSI 3.6%
    PRS 43.5%
  • pancreatic stellate cell CL0002410
    CSI 0.3
    rCSI 1.6%
    PRS 27.1%
  • granulocyte monocyte progenitor cell CL0000557
    CSI 0.3
    rCSI 0.2%
    PRS 20.4%
  • tracheobronchial serous cell CL0019001
    CSI 0.3
    rCSI 1.2%
    PRS 33.6%
  • peptic cell CL0000155
    CSI 0.3
    rCSI 2.8%
    PRS 47.8%
  • deuterosomal cell CL4033044
    CSI 0.3
    rCSI 1.0%
    PRS 29.3%
  • type B pancreatic cell CL0000169
    CSI 0.3
    rCSI 0.7%
    PRS 16.8%
  • antibody secreting cell CL0000946
    CSI 0.3
    rCSI 1.4%
    PRS 64.1%
  • M cell of gut CL0000682
    CSI 0.3
    rCSI 0.4%
    PRS 31.4%
  • eosinophil CL0000771
    CSI 0.3
    rCSI 2.2%
    PRS 45.5%
  • CD4-positive, alpha-beta cytotoxic T cell CL0000934
    CSI 0.3
    rCSI 0.5%
    PRS 36.3%
  • vasa recta ascending limb cell CL1001131
    CSI 0.3
    rCSI 1.5%
    PRS 55.9%
  • syncytiotrophoblast cell CL0000525
    CSI 0.3
    rCSI 1.0%
    PRS 34.1%
  • cone retinal bipolar cell CL0000752
    CSI 0.3
    rCSI 4.5%
    PRS 55.4%
  • enteroendocrine cell of colon CL0009042
    CSI 0.4
    rCSI 1.7%
    PRS 45.4%
  • basal cell of epithelium of trachea CL1000348
    CSI 0.4
    rCSI 2.5%
    PRS 50.6%
  • CD8-positive, alpha-beta memory T cell, CD45RO-positive CL0001203
    CSI 0.4
    rCSI 0.5%
    PRS 22.8%
  • germinal center B cell CL0000844
    CSI 0.4
    rCSI 1.2%
    PRS 42.2%
  • basal-myoepithelial cell of mammary gland CL0002324
    CSI 0.4
    rCSI 0.7%
    PRS 38.4%
  • endothelial cell of venule CL1000414
    CSI 0.4
    rCSI 3.6%
    PRS 59.8%
  • effector memory CD8-positive, alpha-beta T cell CL0000913
    CSI 0.4
    rCSI 0.4%
    PRS 27.6%
  • luminal cell of prostate epithelium CL0002340
    CSI 0.4
    rCSI 2.3%
    PRS 32.2%
  • P/D1 enteroendocrine cell CL0002268
    CSI 0.4
    rCSI 2.4%
    PRS 42.3%
  • colon macrophage CL0009038
    CSI 0.4
    rCSI 2.1%
    PRS 37.5%
  • thymocyte CL0000893
    CSI 0.5
    rCSI 1.6%
    PRS 53.8%
  • intestinal epithelial cell CL0002563
    CSI 0.5
    rCSI 0.5%
    PRS 19.0%
  • erythroblast CL0000765
    CSI 0.5
    rCSI 1.3%
    PRS 29.2%
  • macroglial cell CL0000126
    CSI 0.5
    rCSI 1.3%
    PRS 23.8%
  • intrahepatic cholangiocyte CL0002538
    CSI 0.5
    rCSI 1.2%
    PRS 32.4%
  • muscle cell CL0000187
    CSI 0.5
    rCSI 1.0%
    PRS 39.6%
  • small pre-B-II cell CL0000954
    CSI 0.5
    rCSI 0.5%
    PRS 36.8%
  • mature alpha-beta T cell CL0000791
    CSI 0.5
    rCSI 1.9%
    PRS 31.1%
  • endothelial cell of uterus CL0009095
    CSI 0.5
    rCSI 4.0%
    PRS 47.4%
  • progenitor cell CL0011026
    CSI 0.5
    rCSI 1.2%
    PRS 29.1%
  • pancreatic epsilon cell CL0005019
    CSI 0.6
    rCSI 2.6%
    PRS 40.8%
  • fibroblast of breast CL4006000
    CSI 0.6
    rCSI 2.3%
    PRS 44.1%
  • neuroendocrine cell CL0000165
    CSI 0.6
    rCSI 2.2%
    PRS 36.0%
  • exhausted T cell CL0011025
    CSI 0.6
    rCSI 9.7%
    PRS 59.5%
  • bronchiolar smooth muscle cell CL4033017
    CSI 0.6
    rCSI 8.7%
    PRS 50.6%
  • airway submucosal gland duct basal cell CL4033024
    CSI 0.6
    rCSI 3.8%
    PRS 45.6%
  • basal cell of prostate epithelium CL0002341
    CSI 0.6
    rCSI 1.8%
    PRS 38.9%
  • effector CD4-positive, alpha-beta T cell CL0001044
    CSI 0.6
    rCSI 1.8%
    PRS 26.8%
  • central memory CD8-positive, alpha-beta T cell CL0000907
    CSI 0.6
    rCSI 0.4%
    PRS 22.1%
  • IgG plasma cell CL0000985
    CSI 0.6
    rCSI 0.8%
    PRS 31.3%
  • megakaryocyte CL0000556
    CSI 0.7
    rCSI 2.8%
    PRS 31.7%
  • helper T cell CL0000912
    CSI 0.7
    rCSI 0.9%
    PRS 25.1%
  • hematopoietic multipotent progenitor cell CL0000837
    CSI 0.7
    rCSI 1.7%
    PRS 28.7%
  • intestine goblet cell CL0019031
    CSI 0.7
    rCSI 0.6%
    PRS 18.2%
  • lung neuroendocrine cell CL1000223
    CSI 0.7
    rCSI 1.1%
    PRS 20.7%
  • pulmonary ionocyte CL0017000
    CSI 0.7
    rCSI 0.9%
    PRS 22.8%
  • pancreatic acinar cell CL0002064
    CSI 0.8
    rCSI 1.0%
    PRS 19.9%
  • respiratory suprabasal cell CL4033048
    CSI 0.8
    rCSI 1.0%
    PRS 20.9%
  • Cajal-Retzius cell CL0000695
    CSI 0.8
    rCSI 6.0%
    PRS 37.0%
  • dendritic cell, human CL0001056
    CSI 0.8
    rCSI 1.2%
    PRS 21.6%
  • alveolar adventitial fibroblast CL4028006
    CSI 0.8
    rCSI 1.3%
    PRS 18.2%
  • CD1c-positive myeloid dendritic cell CL0002399
    CSI 0.8
    rCSI 1.0%
    PRS 21.7%
  • lung endothelial cell CL1001567
    CSI 0.8
    rCSI 1.9%
    PRS 41.8%
  • innate lymphoid cell CL0001065
    CSI 0.8
    rCSI 1.7%
    PRS 27.2%
  • stromal cell CL0000499
    CSI 0.8
    rCSI 2.3%
    PRS 24.5%
  • mesothelial cell CL0000077
    CSI 0.8
    rCSI 3.3%
    PRS 5.5%
  • type EC enteroendocrine cell CL0000577
    CSI 0.9
    rCSI 3.0%
    PRS 29.5%
  • fast muscle cell CL0000190
    CSI 0.9
    rCSI 3.4%
    PRS 39.1%
  • mucus secreting cell CL0000319
    CSI 0.9
    rCSI 1.4%
    PRS 23.4%
  • common myeloid progenitor CL0000049
    CSI 0.9
    rCSI 0.7%
    PRS 18.1%
  • memory T cell CL0000813
    CSI 0.9
    rCSI 1.7%
    PRS 40.4%
  • transit amplifying cell CL0009010
    CSI 0.9
    rCSI 1.4%
    PRS 29.3%
  • mature B cell CL0000785
    CSI 0.9
    rCSI 0.8%
    PRS 22.7%
  • regular ventricular cardiac myocyte CL0002131
    CSI 0.9
    rCSI 5.8%
    PRS 14.1%
  • squamous epithelial cell CL0000076
    CSI 0.9
    rCSI 2.2%
    PRS 22.5%
  • type L enteroendocrine cell CL0002279
    CSI 1.0
    rCSI 1.8%
    PRS 35.5%
  • mammary gland epithelial cell CL0002327
    CSI 1.0
    rCSI 3.4%
    PRS 31.9%
  • Langerhans cell CL0000453
    CSI 1.0
    rCSI 1.5%
    PRS 31.9%
  • renal principal cell CL0005009
    CSI 1.0
    rCSI 2.5%
    PRS 23.4%

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Network Configuration

Explore relationships of the current gene. Select an Interaction Source: 'ONTOLOGY' for shared pathways (GO/Reactome) or 'STRING' for protein-protein interactions. Further refine by selecting context genes and comparing Cell Significance Index (CSI) scores between baseline and target cell types and their specific contexts.

Comma-separated if multiple.
Comma-separated if multiple.

Legend:
  • Query Gene
  • Node Color (Target Cell CSI, relative to current network):
    • Very High
    • High
    • Medium
    • Low
    • Very Low
    • CSI N/A
  • Node Size: Proportional to Target Cell CSI magnitude
  • STRING PPI Edge
  • Shared Pathway Edge (ONTOLOGY)

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Other Information

This section provides additional information about the gene, including a description generated by an AI language model and details about associated proteins.

## Summary [ASH1L](/details-gene/55870) (ASH1 like histone lysine methyltransferase) is a protein-coding gene located on chromosome 1q22. It encodes a key epigenetic modifier belonging to the trithorax-group of proteins. As a histone-lysine N-methyltransferase, [ASH1L](/details-gene/55870) is primarily involved in [Chromatin remodeling](/details-pathway/GO:0006338) and the [Positive regulation of transcription by rna polymerase ii](/details-pathway/GO:0045944). Expression data indicates that **Overall**, [ASH1L](/details-gene/55870) is a highly significant gene in the central nervous system, showing prominent expression in multiple subtypes of cortical interneurons, including [VIP GABAergic cortical interneuron](/details-cell/CL4023016) and [sst GABAergic cortical interneuron](/details-cell/CL4023017). Its function as a chromatin writer, coupled with this specific expression pattern, suggests a critical role in establishing and maintaining the transcriptional identity of specialized neuronal populations. ## Cellular Roles and Expression Landscape The expression profile of [ASH1L](/details-gene/55870) highlights its fundamental role in the identity and function of specific, terminally differentiated cell types, particularly within the cerebral cortex. **Overall**, the gene shows its highest significance in a range of inhibitory interneurons, including [VIP GABAergic cortical interneuron](/details-cell/CL4023016) (CSI: 72.52), [sst GABAergic cortical interneuron](/details-cell/CL4023017) (CSI: 65.80), and [pvalb GABAergic cortical interneuron](/details-cell/CL4023018) (CSI: 60.16), as well as in excitatory glutamatergic neurons like [L2/3-6 intratelencephalic projecting glutamatergic neuron](/details-cell/CL4023040). This strong and specific expression signature suggests that [ASH1L](/details-gene/55870) is a key regulator of neuronal transcriptional programs that define these distinct subtypes. Beyond the nervous system, [ASH1L](/details-gene/55870) also demonstrates significant expression in other specialized cells such as [adipocyte](/details-cell/CL0000136) and [cardiac muscle cell](/details-cell/CL0000746), indicating a broader role in maintaining the functional state of metabolically active tissues. Conversely, the gene's expression is notably low or absent in hematopoietic lineages and progenitor cells. For example, it is an anti-marker for [class switched memory B cell](/details-cell/CL0000972) (CSI: -5.23), [fraction A pre-pro B cell](/details-cell/CL0002045), and [promonocyte](/details-cell/CL0000559). This lack of expression in immune and progenitor populations underscores its specialized function in differentiated, long-lived cells rather than in rapidly proliferating or developmental lineages. ## Pathways and Molecular Function [ASH1L](/details-gene/55870) functions as a catalytic subunit of a histone methyltransferase complex, playing a direct role in epigenetic regulation. Its molecular functions are centered on [Histone h3 methyltransferase activity](/details-pathway/GO:0140938), with specific activities documented for H3K36 ([GO:0046975](https://www.ebi.ac.uk/QuickGO/term/GO:0046975)), H3K4 ([GO:0042800](https://www.ebi.ac.uk/QuickGO/term/GO:0042800)), and H3K9 ([GO:0046974](https://www.ebi.ac.uk/QuickGO/term/GO:0046974)) methylation. These activities are integral to the Reactome pathways of [Chromatin modifying enzymes](/details-pathway/R-HSA-3247509) and [Chromatin organization](/details-pathway/R-HSA-4839726). By modifying histones, [ASH1L](/details-gene/55870) directly influences gene expression, primarily through the [Positive regulation of transcription by rna polymerase ii](/details-pathway/GO:0045944). This mechanism is consistent with its high expression in functionally complex cells like neurons, where precise, stable, and long-term control of gene expression is paramount. The protein primarily localizes to the [Nucleus](/details-pathway/GO:0005634) and associates with [Chromosome](/details-pathway/GO:0005694) to execute its function. Interestingly, one study also reported its localization to [Bicellular tight junction](/details-pathway/GO:0005923), suggesting a potential non-nuclear role in cell-cell adhesion ([Link](https://doi.org/10.1073/pnas.97.13.7284)). The gene is also annotated to biological processes such as [Skeletal system development](/details-pathway/GO:0001501) and [Inflammatory response](/details-pathway/GO:0006954), indicating its pleiotropic effects. ## Research Directions The specific expression pattern and enzymatic function of [ASH1L](/details-gene/55870) position it as a critical regulator of cellular identity, particularly in the nervous system. Future research should focus on elucidating its precise roles in neuronal subtype specification and its potential involvement in neurological disorders. **Proposed Hypotheses:** 1. **[ASH1L](/details-gene/55870) is essential for the epigenetic maintenance of cortical interneuron identity.** Given its high significance in multiple interneuron subtypes ([VIP GABAergic cortical interneuron](/details-cell/CL4023016), [sst GABAergic cortical interneuron](/details-cell/CL4023017)), we hypothesize that its histone methyltransferase activity establishes and maintains the unique transcriptional programs that define these cells. Loss of [ASH1L](/details-gene/55870) in these neurons would lead to a drift in their cellular identity, impaired function, and potential circuit disruption. 2. **[ASH1L](/details-gene/55870) regulates metabolic gene expression programs in adipocytes and cardiac muscle cells.** Its high expression in [adipocyte](/details-cell/CL0000136) and [cardiac muscle cell](/details-cell/CL0000746) suggests a role beyond neurodevelopment. We hypothesize that [ASH1L](/details-gene/55870) controls the expression of key metabolic genes in these tissues, and its dysregulation could contribute to metabolic or cardiovascular diseases. **Key Experimental Approach:** To test the hypothesis that [ASH1L](/details-gene/55870) is critical for maintaining cortical interneuron identity, a conditional knockout (cKO) mouse model could be employed. By crossing a floxed [ASH1L](/details-gene/55870) mouse line with a Cre-driver line specific to cortical interneurons (e.g., *SST-Cre* or *VIP-Cre*), the gene can be selectively deleted in the target cell population. Subsequent analysis using single-cell RNA-seq and single-cell ATAC-seq on the cortex of cKO and control animals would reveal changes in gene expression and chromatin accessibility. This would directly determine if [ASH1L](/details-gene/55870) is required to maintain the transcriptional and epigenetic integrity of these specific neuronal subtypes. **Therapeutic Potential:** As a histone methyltransferase, [ASH1L](/details-gene/55870) is a druggable enzyme. Loss-of-function mutations have been associated with severe intellectual disability ([Link](https://doi.org/10.1056/nejmoa1206524)), suggesting that its role in neurodevelopment is clinically significant. Therefore, therapeutic strategies could be envisioned for neurodevelopmental disorders, potentially involving small molecules that modulate its enzymatic activity. However, its crucial role in other vital, terminally differentiated cells like [cardiac muscle cell](/details-cell/CL0000746) presents a significant challenge for systemic therapies, which could lead to severe cardiotoxicity. Future therapeutic development would likely require highly targeted delivery mechanisms or cell-type specific modulators to be viable. Depending on the nature of the disease-causing mutation, both inhibition (for gain-of-function) and activation/restoration (for loss-of-function) could be relevant strategies.

Genular Protein ID: 1957183779

Symbol: ASH1L_HUMAN

Name: Histone-lysine N-methyltransferase ASH1L

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 10860993

Title: huASH1 protein, a putative transcription factor encoded by a human homologue of the Drosophila ash1 gene, localizes to both nuclei and cell-cell tight junctions.

PubMed ID: 10860993

DOI: 10.1073/pnas.97.13.7284

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 10718198

Title: Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro.

PubMed ID: 10718198

DOI: 10.1093/dnares/7.1.65

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 18220336

Title: Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis.

PubMed ID: 18220336

DOI: 10.1021/pr0705441

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 22939622

Title: Prdm3 and Prdm16 are H3K9me1 methyltransferases required for mammalian heterochromatin integrity.

PubMed ID: 22939622

DOI: 10.1016/j.cell.2012.06.048

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 25593309

Title: Screen identifies bromodomain protein ZMYND8 in chromatin recognition of transcription-associated DNA damage that promotes homologous recombination.

PubMed ID: 25593309

DOI: 10.1101/gad.252189.114

PubMed ID: 26797129

Title: Substrate specificity of the HEMK2 protein glutamine methyltransferase and identification of novel substrates.

PubMed ID: 26797129

DOI: 10.1074/jbc.m115.711952

PubMed ID: 28112733

Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.

PubMed ID: 28112733

DOI: 10.1038/nsmb.3366

PubMed ID: 21239497

Title: Crystal structure of the human histone methyltransferase ASH1L catalytic domain and its implications for the regulatory mechanism.

PubMed ID: 21239497

DOI: 10.1074/jbc.m110.203380

PubMed ID: 22464331

Title: Histone recognition and large-scale structural analysis of the human bromodomain family.

PubMed ID: 22464331

DOI: 10.1016/j.cell.2012.02.013

PubMed ID: 23033978

Title: Diagnostic exome sequencing in persons with severe intellectual disability.

PubMed ID: 23033978

DOI: 10.1056/nejmoa1206524

PubMed ID: 27824329

Title: De novo genic mutations among a Chinese autism spectrum disorder cohort.

PubMed ID: 27824329

DOI: 10.1038/ncomms13316

PubMed ID: 28394464

Title: Novel MCA/ID syndrome with ASH1L mutation.

PubMed ID: 28394464

DOI: 10.1002/ajmg.a.38193

PubMed ID: 28191889

Title: Targeted sequencing identifies 91 neurodevelopmental-disorder risk genes with autism and developmental-disability biases.

PubMed ID: 28191889

DOI: 10.1038/ng.3792

Sequence Information:

  • Length: 2969
  • Mass: 332790
  • Checksum: DA0135C72A2E2065
  • Sequence:
  • MDPRNTAMLG LGSDSEGFSR KSPSAISTGT LVSKREVELE KNTKEEEDLR KRNRERNIEA 
    GKDDGLTDAQ QQFSVKETNF SEGNLKLKIG LQAKRTKKPP KNLENYVCRP AIKTTIKHPR 
    KALKSGKMTD EKNEHCPSKR DPSKLYKKAD DVAAIECQSE EVIRLHSQGE NNPLSKKLSP 
    VHSEMADYIN ATPSTLLGSR DPDLKDRALL NGGTSVTEKL AQLIATCPPS KSSKTKPKKL 
    GTGTTAGLVS KDLIRKAGVG SVAGIIHKDL IKKPTISTAV GLVTKDPGKK PVFNAAVGLV 
    NKDSVKKLGT GTTAVFINKN LGKKPGTITT VGLLSKDSGK KLGIGIVPGL VHKESGKKLG 
    LGTVVGLVNK DLGKKLGSTV GLVAKDCAKK IVASSAMGLV NKDIGKKLMS CPLAGLISKD 
    AINLKAEALL PTQEPLKASC STNINNQESQ ELSESLKDSA TSKTFEKNVV RQNKESILEK 
    FSVRKEIINL EKEMFNEGTC IQQDSFSSSE KGSYETSKHE KQPPVYCTSP DFKMGGASDV 
    STAKSPFSAV GESNLPSPSP TVSVNPLTRS PPETSSQLAP NPLLLSSTTE LIEEISESVG 
    KNQFTSESTH LNVGHRSVGH SISIECKGID KEVNDSKTTH IDIPRISSSL GKKPSLTSES 
    SIHTITPSVV NFTSLFSNKP FLKLGAVSAS DKHCQVAESL STSLQSKPLK KRKGRKPRWT 
    KVVARSTCRS PKGLELERSE LFKNVSCSSL SNSNSEPAKF MKNIGPPSFV DHDFLKRRLP 
    KLSKSTAPSL ALLADSEKPS HKSFATHKLS SSMCVSSDLL SDIYKPKRGR PKSKEMPQLE 
    GPPKRTLKIP ASKVFSLQSK EEQEPPILQP EIEIPSFKQG LSVSPFPKKR GRPKRQMRSP 
    VKMKPPVLSV APFVATESPS KLESESDNHR SSSDFFESED QLQDPDDLDD SHRPSVCSMS 
    DLEMEPDKKI TKRNNGQLMK TIIRKINKMK TLKRKKLLNQ ILSSSVESSN KGKVQSKLHN 
    TVSSLAATFG SKLGQQINVS KKGTIYIGKR RGRKPKTVLN GILSGSPTSL AVLEQTAQQA 
    AGSALGQILP PLLPSSASSS EILPSPICSQ SSGTSGGQSP VSSDAGFVEP SSVPYLHLHS 
    RQGSMIQTLA MKKASKGRRR LSPPTLLPNS PSHLSELTSL KEATPSPISE SHSDETIPSD 
    SGIGTDNNST SDRAEKFCGQ KKRRHSFEHV SLIPPETSTV LSSLKEKHKH KCKRRNHDYL 
    SYDKMKRQKR KRKKKYPQLR NRQDPDFIAE LEELISRLSE IRITHRSHHF IPRDLLPTIF 
    RINFNSFYTH PSFPLDPLHY IRKPDLKKKR GRPPKMREAM AEMPFMHSLS FPLSSTGFYP 
    SYGMPYSPSP LTAAPIGLGY YGRYPPTLYP PPPSPSFTTP LPPPSYMHAG HLLLNPAKYH 
    KKKHKLLRQE AFLTTSRTPL LSMSTYPSVP PEMAYGWMVE HKHRHRHKHR EHRSSEQPQV 
    SMDTGSSRSV LESLKRYRFG KDAVGERYKH KEKHRCHMSC PHLSPSKSLI NREEQWVHRE 
    PSESSPLALG LQTPLQIDCS ESSPSLSLGG FTPNSEPASS DEHTNLFTSA IGSCRVSNPN 
    SSGRKKLTDS PGLFSAQDTS LNRLHRKESL PSNERAVQTL AGSQPTSDKP SQRPSESTNC 
    SPTRKRSSSE STSSTVNGVP SRSPRLVASG DDSVDSLLQR MVQNEDQEPM EKSIDAVIAT 
    ASAPPSSSPG RSHSKDRTLG KPDSLLVPAV TSDSCNNSIS LLSEKLTSSC SPHHIKRSVV 
    EAMQRQARKM CNYDKILATK KNLDHVNKIL KAKKLQRQAR TGNNFVKRRP GRPRKCPLQA 
    VVSMQAFQAA QFVNPELNRD EEGAALHLSP DTVTDVIEAV VQSVNLNPEH KKGLKRKGWL 
    LEEQTRKKQK PLPEEEEQEN NKSFNEAPVE IPSPSETPAK PSEPESTLQP VLSLIPREKK 
    PPRPPKKKYQ KAGLYSDVYK TTDPKSRLIQ LKKEKLEYTP GEHEYGLFPA PIHVVFFVSG 
    KYLRQKRIDF QLPYDILWQW KHNQLYKKPD VPLYKKIRSN VYVDVKPLSG YEATTCNCKK 
    PDDDTRKGCV DDCLNRMIFA ECSPNTCPCG EQCCNQRIQR HEWVQCLERF RAEEKGWGIR 
    TKEPLKAGQF IIEYLGEVVS EQEFRNRMIE QYHNHSDHYC LNLDSGMVID SYRMGNEARF 
    INHSCDPNCE MQKWSVNGVY RIGLYALKDM PAGTELTYDY NFHSFNVEKQ QLCKCGFEKC 
    RGIIGGKSQR VNGLTSSKNS QPMATHKKSG RSKEKRKSKH KLKKRRGHLS EEPSENINTP 
    TRLTPQLQMK PMSNRERNFV LKHHVFLVRN WEKIRQKQEE VKHTSDNIHS ASLYTRWNGI 
    CRDDGNIKSD VFMTQFSALQ TARSVRTRRL AAAEENIEVA RAARLAQIFK EICDGIISYK 
    DSSRQALAAP LLNLPPKKKN ADYYEKISDP LDLITIEKQI LTGYYKTVEA FDADMLKVFR 
    NAEKYYGRKS PVGRDVCRLR KAYYNARHEA SAQIDEIVGE TASEADSSET SVSEKENGHE 
    KDDDVIRCIC GLYKDEGLMI QCDKCMVWQH CDCMGVNSDV EHYLCEQCDP RPVDREVPMI 
    PRPHYAQPGC VYFICLLRDD LLLRQGDCVY LMRDSRRTPD GHPVRQSYRL LSHINRDKLD 
    IFRIEKLWKN EKEERFAFGH HYFRPHETHH SPSRRFYHNE LFRVPLYEII PLEAVVGTCC 
    VLDLYTYCKG RPKGVKEQDV YICDYRLDKS AHLFYKIHRN RYPVCTKPYA FDHFPKKLTP 
    KKDFSPHYVP DNYKRNGGRS SWKSERSKPP LKDLGQEDDA LPLIEEVLAS QEQAANEIPS 
    LEEPEREGAT ANVSEGEKKT EESSQEPQST CTPEERRHNQ RERLNQILLN LLEKIPGKNA 
    IDVTYLLEEG SGRKLRRRTL FIPENSFRK

Genular Protein ID: 1365515999

Symbol: A0A7I2V3D6_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

Sequence Information:

  • Length: 1726
  • Mass: 189765
  • Checksum: 3DA6C8E17069B769
  • Sequence:
  • MDPRNTAMLG LGSDSEGFSR KSPSAISTGT LVSKREVELE KNTKEEEDLR KRNRERNIEA 
    GKDDGLTDAQ QQFSVKETNF SEGNLKLKIG LQAKRTKKPP KNLENYVCRP AIKTTIKHPR 
    KALKSGKMTD EKNEHCPSKR DPSKLYKKAD DVAAIECQSE EVIRLHSQGE NNPLSKKLSP 
    VHSEMADYIN ATPSTLLGSR DPDLKDRALL NGGTSVTEKL AQLIATCPPS KSSKTKPKKL 
    GTGTTAGLVS KDLIRKAGVG SVAGIIHKDL IKKPTISTAV GLVTKDPGKK PVFNAAVGLV 
    NKDSVKKLGT GTTAVFINKN LGKKPGTITT VGLLSKDSGK KLGIGIVPGL VHKESGKKLG 
    LGTVVGLVNK DLGKKLGSTV GLVAKDCAKK IVASSAMGLV NKDIGKKLMS CPLAGLISKD 
    AINLKAEALL PTQEPLKASC STNINNQESQ ELSESLKDSA TSKTFEKNVV RQNKESILEK 
    FSVRKEIINL EKEMFNEGTC IQQDSFSSSE KGSYETSKHE KQPPVYCTSP DFKMGGASDV 
    STAKSPFSAV GESNLPSPSP TVSVNPLTRS PPETSSQLAP NPLLLSSTTE LIEEISESVG 
    KNQFTSESTH LNVGHRSVGH SISIECKGID KEVNDSKTTH IDIPRISSSL GKKPSLTSES 
    SIHTITPSVV NFTSLFSNKP FLKLGAVSAS DKHCQVAESL STSLQSKPLK KRKGRKPRWT 
    KVVARSTCRS PKGLELERSE LFKNVSCSSL SNSNSEPAKF MKNIGPPSFV DHDFLKRRLP 
    KLSKSTAPSL ALLADSEKPS HKSFATHKLS SSMCVSSDLL SDIYKPKRGR PKSKEMPQLE 
    GPPKRTLKIP ASKVFSLQSK EEQEPPILQP EIEIPSFKQG LSVSPFPKKR GRPKRQMRSP 
    VKMKPPVLSV APFVATESPS KLESESDNHR SSSDFFESED QLQDPDDLDD SHRPSVCSMS 
    DLEMEPDKKI TKRNNGQLMK TIIRKINKMK TLKRKKLLNQ ILSSSVESSN KGKVQSKLHN 
    TVSSLAATFG SKLGQQINVS KKGTIYIGKR RGRKPKTVLN GILSGSPTSL AVLEQTAQQA 
    AGSALGQILP PLLPSSASSS EILPSPICSQ SSGTSGGQSP VSSDAGFVEP SSVPYLHLHS 
    RQGSMIQTLA MKKASKGRRR LSPPTLLPNS PSHLSELTSL KEATPSPISE SHSDETIPSD 
    SGIGTDNNST SDRAEKFCGQ KKRRHSFEHV SLIPPETSTV LSSLKEKHKH KCKRRNHDYL 
    SYDKMKRQKR KRKKKYPQLR NRQDPDFIAE LEELISRLSE IRITHRSHHF IPRDLLPTIF 
    RINFNSFYTH PSFPLDPLHY IRKPDLKKKR GRPPKMREAM AEMPFMHSLS FPLSSTGFYP 
    SYGMPYSPSP LTAAPIGLGY YGRYPPTLYP PPPSPSFTTP LPPPSYMHAG HLLLNPAKYH 
    KKKHKLLRQE AFLTTSRTPL LSMSTYPSVP PEMAYGWMVE HKHRHRHKHR EHRSSEQPQV 
    SMDTGSSRSV LESLKRYRFG KDAVGERYKH KEKHRCHMSC PHLSPSKSLI NREEQWVHRE 
    PSESSPLALG LQTPLQIDCS ESSPSLSLGG FTPNSEPASS DEHTNLFTSA IGSCRVSNPN 
    SSGRKKLTDS PGLFSAQDTS LNRLHRKESL PSNERAVQTL AGSQPTSDKP SQRPSESTNC 
    SPTRKRSSSE STSSTDKTED WYEYLEVTYI LMIIETMRIN MFPVGK

Genular Protein ID: 582190489

Symbol: A0A7I2V316_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

Sequence Information:

  • Length: 1741
  • Mass: 191447
  • Checksum: FD75CABCFE3D482C
  • Sequence:
  • MDPRNTAMLG LGSDSEGFSR KSPSAISTGT LVSKREVELE KNTKEEEDLR KRNRERNIEA 
    GKDDGLTDAQ QQFSVKETNF SEGNLKLKIG LQAKRTKKPP KNLENYVCRP AIKTTIKHPR 
    KALKSGKMTD EKNEHCPSKR DPSKLYKKAD DVAAIECQSE EVIRLHSQGE NNPLSKKLSP 
    VHSEMADYIN ATPSTLLGSR DPDLKDRALL NGGTSVTEKL AQLIATCPPS KSSKTKPKKL 
    GTGTTAGLVS KDLIRKAGVG SVAGIIHKDL IKKPTISTAV GLVTKDPGKK PVFNAAVGLV 
    NKDSVKKLGT GTTAVFINKN LGKKPGTITT VGLLSKDSGK KLGIGIVPGL VHKESGKKLG 
    LGTVVGLVNK DLGKKLGSTV GLVAKDCAKK IVASSAMGLV NKDIGKKLMS CPLAGLISKD 
    AINLKAEALL PTQEPLKASC STNINNQESQ ELSESLKDSA TSKTFEKNVV RQNKESILEK 
    FSVRKEIINL EKEMFNEGTC IQQDSFSSSE KGSYETSKHE KQPPVYCTSP DFKMGGASDV 
    STAKSPFSAV GESNLPSPSP TVSVNPLTRS PPETSSQLAP NPLLLSSTTE LIEEISESVG 
    KNQFTSESTH LNVGHRSVGH SISIECKGID KEVNDSKTTH IDIPRISSSL GKKPSLTSES 
    SIHTITPSVV NFTSLFSNKP FLKLGAVSAS DKHCQVAESL STSLQSKPLK KRKGRKPRWT 
    KVVARSTCRS PKGLELERSE LFKNVSCSSL SNSNSEPAKF MKNIGPPSFV DHDFLKRRLP 
    KLSKSTAPSL ALLADSEKPS HKSFATHKLS SSMCVSSDLL SDIYKPKRGR PKSKEMPQLE 
    GPPKRTLKIP ASKVFSLQSK EEQEPPILQP EIEIPSFKQG LSVSPFPKKR GRPKRQMRSP 
    VKMKPPVLSV APFVATESPS KLESESDNHR SSSDFFESED QLQDPDDLDD SHRPSVCSMS 
    DLEMEPDKKI TKRNNGQLMK TIIRKINKMK TLKRKKLLNQ ILSSSVESSN KGKVQSKLHN 
    TVSSLAATFG SKLGQQINVS KKGTIYIGKR RGRKPKTVLN GILSGSPTSL AVLEQTAQQA 
    AGSALGQILP PLLPSSASSS EILPSPICSQ SSGTSGGQSP VSSDAGFVEP SSVPYLHLHS 
    RQGSMIQTLA MKKASKGRRR LSPPTLLPNS PSHLSELTSL KEATPSPISE SHSDETIPSD 
    SGIGTDNNST SDRAEKFCGQ KKRRHSFEHV SLIPPETSTV LSSLKEKHKH KCKRRNHDYL 
    SYDKMKRQKR KRKKKYPQLR NRQDPDFIAE LEELISRLSE IRITHRSHHF IPRDLLPTIF 
    RINFNSFYTH PSFPLDPLHY IRKPDLKKKR GRPPKMREAM AEMPFMHSLS FPLSSTGFYP 
    SYGMPYSPSP LTAAPIGLGY YGRYPPTLYP PPPSPSFTTP LPPPSYMHAG HLLLNPAKYH 
    KKKHKLLRQE AFLTTSRTPL LSMSTYPSVP PEMAYGWMVE HKHRHRHKHR EHRSSEQPQV 
    SMDTGSSRSV LESLKRYRFG KDAVGERYKH KEKHRCHMSC PHLSPSKSLI NREEQWVHRE 
    PSESSPLALG LQTPLQIDCS ESSPSLSLGG FTPNSEPASS DEHTNLFTSA IGSCRVSNPN 
    SSGRKKLTDS PGLFSAQDTS LNRLHRKESL PSNERAVQTL AGSQPTSDKP SQRPSESTNC 
    SPTRKRSSSE STSSTDKTED WYEYLEVTYI LMIIETMRIN MFPVGNKRSS LSKSKISCFW 
    G