Details for: RBPJ
Associated with
Cells (max top 100)
(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)
- Cell Name: polychromatophilic erythroblast (CL0000550)
Fold Change: 610.7870
Cell Significance Index: -95.0100 - Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
Fold Change: 354.1587
Cell Significance Index: -89.8300 - Cell Name: embryonic stem cell (CL0002322)
Fold Change: 211.9444
Cell Significance Index: -87.3100 - Cell Name: smooth muscle fiber of ileum (CL1000278)
Fold Change: 209.4159
Cell Significance Index: -98.8700 - Cell Name: mucosal type mast cell (CL0000485)
Fold Change: 198.0150
Cell Significance Index: -80.4500 - Cell Name: peripheral blood mononuclear cell (CL2000001)
Fold Change: 174.5190
Cell Significance Index: -89.7700 - Cell Name: ileal goblet cell (CL1000326)
Fold Change: 148.0875
Cell Significance Index: -99.3700 - Cell Name: ciliated cell of the bronchus (CL0002332)
Fold Change: 84.7872
Cell Significance Index: -80.9500 - Cell Name: orthochromatic erythroblast (CL0000552)
Fold Change: 79.2364
Cell Significance Index: -97.7000 - Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
Fold Change: 31.9782
Cell Significance Index: -85.6700 - Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
Fold Change: 27.9444
Cell Significance Index: -85.8300 - Cell Name: stromal cell of bone marrow (CL0010001)
Fold Change: 24.9009
Cell Significance Index: -98.2600 - Cell Name: epidermal Langerhans cell (CL0002457)
Fold Change: 19.8850
Cell Significance Index: -43.5200 - Cell Name: retinal progenitor cell (CL0002672)
Fold Change: 3.9984
Cell Significance Index: 224.3700 - Cell Name: preadipocyte (CL0002334)
Fold Change: 2.8708
Cell Significance Index: 56.0300 - Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: 2.1455
Cell Significance Index: 430.3900 - Cell Name: tuft cell of colon (CL0009041)
Fold Change: 1.9287
Cell Significance Index: 1741.4700 - Cell Name: neoplastic cell (CL0001063)
Fold Change: 1.6183
Cell Significance Index: 321.1600 - Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
Fold Change: 1.3597
Cell Significance Index: 47.2500 - Cell Name: stromal cell of ovary (CL0002132)
Fold Change: 1.3260
Cell Significance Index: 182.1000 - Cell Name: intermediate cell of urothelium (CL4030055)
Fold Change: 1.3090
Cell Significance Index: 235.9800 - Cell Name: skeletal muscle fiber (CL0008002)
Fold Change: 1.2951
Cell Significance Index: 33.2900 - Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: 1.1999
Cell Significance Index: 430.3700 - Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
Fold Change: 1.0891
Cell Significance Index: 20.1300 - Cell Name: basal cell of urothelium (CL1000486)
Fold Change: 0.9821
Cell Significance Index: 120.7600 - Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: 0.9693
Cell Significance Index: 74.3800 - Cell Name: hair follicular keratinocyte (CL2000092)
Fold Change: 0.9182
Cell Significance Index: 405.9400 - Cell Name: cell in vitro (CL0001034)
Fold Change: 0.8643
Cell Significance Index: 472.0200 - Cell Name: fibroblast of mammary gland (CL0002555)
Fold Change: 0.8358
Cell Significance Index: 23.9600 - Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: 0.6376
Cell Significance Index: 121.3400 - Cell Name: GABAergic interneuron (CL0011005)
Fold Change: 0.5394
Cell Significance Index: 373.0900 - Cell Name: forebrain neuroblast (CL1000042)
Fold Change: 0.5330
Cell Significance Index: 32.7600 - Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
Fold Change: 0.3892
Cell Significance Index: 18.2900 - Cell Name: colon goblet cell (CL0009039)
Fold Change: 0.3500
Cell Significance Index: 34.6200 - Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: 0.3463
Cell Significance Index: 652.0600 - Cell Name: odontoblast (CL0000060)
Fold Change: 0.3419
Cell Significance Index: 43.8300 - Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 0.3418
Cell Significance Index: 9.8500 - Cell Name: lung endothelial cell (CL1001567)
Fold Change: 0.2964
Cell Significance Index: 15.4400 - Cell Name: lens epithelial cell (CL0002224)
Fold Change: 0.2776
Cell Significance Index: 427.2800 - Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: 0.2645
Cell Significance Index: 11.9900 - Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
Fold Change: 0.2414
Cell Significance Index: 7.0900 - Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: 0.2183
Cell Significance Index: 37.2700 - Cell Name: anterior lens cell (CL0002223)
Fold Change: 0.2072
Cell Significance Index: 382.1600 - Cell Name: secondary lens fiber (CL0002225)
Fold Change: 0.1632
Cell Significance Index: 221.9300 - Cell Name: glycinergic neuron (CL1001509)
Fold Change: 0.1619
Cell Significance Index: 8.5000 - Cell Name: hippocampal granule cell (CL0001033)
Fold Change: 0.1357
Cell Significance Index: 9.1300 - Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: 0.1164
Cell Significance Index: 73.9200 - Cell Name: early pro-B cell (CL0002046)
Fold Change: 0.1100
Cell Significance Index: 7.1000 - Cell Name: ciliary muscle cell (CL1000443)
Fold Change: 0.0785
Cell Significance Index: 35.6200 - Cell Name: lactocyte (CL0002325)
Fold Change: 0.0582
Cell Significance Index: 7.5200 - Cell Name: placental villous trophoblast (CL2000060)
Fold Change: 0.0146
Cell Significance Index: 0.3900 - Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
Fold Change: 0.0140
Cell Significance Index: 0.3900 - Cell Name: pancreatic A cell (CL0000171)
Fold Change: -0.0368
Cell Significance Index: -27.2800 - Cell Name: cerebellar granule cell (CL0001031)
Fold Change: -0.0379
Cell Significance Index: -0.6500 - Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
Fold Change: -0.0489
Cell Significance Index: -35.8600 - Cell Name: pancreatic PP cell (CL0002275)
Fold Change: -0.0691
Cell Significance Index: -43.1800 - Cell Name: pulmonary alveolar epithelial cell (CL0000322)
Fold Change: -0.0876
Cell Significance Index: -66.2800 - Cell Name: bladder urothelial cell (CL1001428)
Fold Change: -0.0897
Cell Significance Index: -4.6600 - Cell Name: abnormal cell (CL0001061)
Fold Change: -0.1029
Cell Significance Index: -10.5100 - Cell Name: type B pancreatic cell (CL0000169)
Fold Change: -0.1269
Cell Significance Index: -71.5800 - Cell Name: mesenchymal cell (CL0008019)
Fold Change: -0.1589
Cell Significance Index: -2.6600 - Cell Name: tonsil germinal center B cell (CL2000006)
Fold Change: -0.2066
Cell Significance Index: -24.3600 - Cell Name: pancreatic D cell (CL0000173)
Fold Change: -0.2569
Cell Significance Index: -54.1000 - Cell Name: microfold cell of epithelium of small intestine (CL1000353)
Fold Change: -0.2601
Cell Significance Index: -17.9900 - Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: -0.2750
Cell Significance Index: -12.8200 - Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: -0.2881
Cell Significance Index: -21.4700 - Cell Name: dopaminergic neuron (CL0000700)
Fold Change: -0.2899
Cell Significance Index: -83.4300 - Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: -0.3323
Cell Significance Index: -48.3000 - Cell Name: sebum secreting cell (CL0000317)
Fold Change: -0.3327
Cell Significance Index: -23.5300 - Cell Name: retinal rod cell (CL0000604)
Fold Change: -0.4840
Cell Significance Index: -5.7700 - Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: -0.4842
Cell Significance Index: -55.4800 - Cell Name: epithelial cell of stomach (CL0002178)
Fold Change: -0.5473
Cell Significance Index: -63.7900 - Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: -0.6099
Cell Significance Index: -63.5000 - Cell Name: pancreatic endocrine cell (CL0008024)
Fold Change: -0.6107
Cell Significance Index: -69.7200 - Cell Name: eye photoreceptor cell (CL0000287)
Fold Change: -0.6126
Cell Significance Index: -38.6100 - Cell Name: granulosa cell (CL0000501)
Fold Change: -0.6161
Cell Significance Index: -16.2000 - Cell Name: basal cell of prostate epithelium (CL0002341)
Fold Change: -0.6786
Cell Significance Index: -18.4700 - Cell Name: indirect pathway medium spiny neuron (CL4023029)
Fold Change: -0.8052
Cell Significance Index: -35.6200 - Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
Fold Change: -0.9081
Cell Significance Index: -19.3400 - Cell Name: direct pathway medium spiny neuron (CL4023026)
Fold Change: -0.9293
Cell Significance Index: -35.1900 - Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
Fold Change: -0.9676
Cell Significance Index: -76.6300 - Cell Name: enteroendocrine cell of small intestine (CL0009006)
Fold Change: -0.9977
Cell Significance Index: -24.9400 - Cell Name: cortical interneuron (CL0008031)
Fold Change: -1.0159
Cell Significance Index: -24.3700 - Cell Name: fibroblast of dermis (CL0002551)
Fold Change: -1.0439
Cell Significance Index: -21.8500 - Cell Name: intestinal tuft cell (CL0019032)
Fold Change: -1.1815
Cell Significance Index: -72.4400 - Cell Name: gut absorptive cell (CL0000677)
Fold Change: -1.2403
Cell Significance Index: -74.4600 - Cell Name: hippocampal pyramidal neuron (CL1001571)
Fold Change: -1.4451
Cell Significance Index: -41.2400 - Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: -1.5555
Cell Significance Index: -49.8200 - Cell Name: conjunctival epithelial cell (CL1000432)
Fold Change: -1.7576
Cell Significance Index: -23.9800 - Cell Name: L6b glutamatergic cortical neuron (CL4023038)
Fold Change: -1.7599
Cell Significance Index: -57.6200 - Cell Name: Hofbauer cell (CL3000001)
Fold Change: -1.8370
Cell Significance Index: -14.9800 - Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
Fold Change: -1.9096
Cell Significance Index: -60.8200 - Cell Name: endothelial cell of placenta (CL0009092)
Fold Change: -2.0176
Cell Significance Index: -12.1900 - Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
Fold Change: -2.1790
Cell Significance Index: -76.3400 - Cell Name: cardiac muscle cell (CL0000746)
Fold Change: -2.2048
Cell Significance Index: -32.5500 - Cell Name: cortical cell of adrenal gland (CL0002097)
Fold Change: -2.2521
Cell Significance Index: -60.3500 - Cell Name: neutrophil progenitor cell (CL0000834)
Fold Change: -2.2692
Cell Significance Index: -60.7000 - Cell Name: skeletal muscle myoblast (CL0000515)
Fold Change: -2.3410
Cell Significance Index: -25.4500 - Cell Name: stratified epithelial cell (CL0000079)
Fold Change: -2.3479
Cell Significance Index: -86.1900 - Cell Name: pro-T cell (CL0000827)
Fold Change: -2.3962
Cell Significance Index: -61.2200
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Other Information
Genular Protein ID: 2136746154
Symbol: SUH_HUMAN
Name: Recombining binding protein suppressor of hairless
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 8406481
Title: Human Jk recombination signal binding protein gene (IGKJRB): comparison with its mouse homologue.
PubMed ID: 8406481
PubMed ID: 14702039
Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.
PubMed ID: 14702039
DOI: 10.1038/ng1285
PubMed ID: 15815621
Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.
PubMed ID: 15815621
DOI: 10.1038/nature03466
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 8016657
Title: Mediation of Epstein-Barr virus EBNA2 transactivation by recombination signal-binding protein J kappa.
PubMed ID: 8016657
PubMed ID: 8627785
Title: The amino-terminal domains of Epstein-Barr virus nuclear proteins 3A, 3B, and 3C interact with RBPJ(kappa).
PubMed ID: 8627785
PubMed ID: 10508479
Title: Antigens recognized by autologous antibody in patients with renal-cell carcinoma.
PubMed ID: 10508479
DOI: 10.1002/(sici)1097-0215(19991112)83:4<456::aid-ijc4>3.0.co;2-5
PubMed ID: 9874765
Title: CIR, a corepressor linking the DNA binding factor CBF1 to the histone deacetylase complex.
PubMed ID: 9874765
DOI: 10.1073/pnas.96.1.23
PubMed ID: 10644367
Title: A role for SKIP in EBNA2 activation of CBF1-repressed promoters.
PubMed ID: 10644367
PubMed ID: 10637481
Title: Intracellular forms of human NOTCH1 interact at distinctly different levels with RBP-jkappa in human B and T cells.
PubMed ID: 10637481
PubMed ID: 12374742
Title: SHARP is a novel component of the Notch/RBP-Jkappa signalling pathway.
PubMed ID: 12374742
DOI: 10.1093/emboj/cdf549
PubMed ID: 21102556
Title: RITA, a novel modulator of Notch signalling, acts via nuclear export of RBP-J.
PubMed ID: 21102556
PubMed ID: 21991380
Title: A SILAC-based screen for Methyl-CpG binding proteins identifies RBP-J as a DNA methylation and sequence-specific binding protein.
PubMed ID: 21991380
PubMed ID: 23571214
Title: BEND6 is a nuclear antagonist of Notch signaling during self-renewal of neural stem cells.
PubMed ID: 23571214
DOI: 10.1242/dev.087502
PubMed ID: 23303788
Title: Oxygen-dependent expression of cytochrome c oxidase subunit 4-2 gene expression is mediated by transcription factors RBPJ, CXXC5 and CHCHD2.
PubMed ID: 23303788
DOI: 10.1093/nar/gks1454
PubMed ID: 26522984
Title: The PIAS-like coactivator Zmiz1 is a direct and selective cofactor of Notch1 in T cell development and leukemia.
PubMed ID: 26522984
PubMed ID: 29030483
Title: RBPJ/CBF1 interacts with L3MBTL3/MBT1 to promote repression of Notch signaling via histone demethylase KDM1A/LSD1.
PubMed ID: 29030483
PubMed ID: 16530044
Title: Structural basis for cooperativity in recruitment of MAML coactivators to Notch transcription complexes.
PubMed ID: 16530044
PubMed ID: 22883147
Title: RBPJ mutations identified in two families affected by Adams-Oliver syndrome.
PubMed ID: 22883147
Sequence Information:
- Length: 500
- Mass: 55637
- Checksum: 91E50D2DE9087EDA
- Sequence:
MDHTEGSPAE EPPAHAPSPG KFGERPPPKR LTREAMRNYL KERGDQTVLI LHAKVAQKSY GNEKRFFCPP PCVYLMGSGW KKKKEQMERD GCSEQESQPC AFIGIGNSDQ EMQQLNLEGK NYCTAKTLYI SDSDKRKHFM LSVKMFYGNS DDIGVFLSKR IKVISKPSKK KQSLKNADLC IASGTKVALF NRLRSQTVST RYLHVEGGNF HASSQQWGAF FIHLLDDDES EGEEFTVRDG YIHYGQTVKL VCSVTGMALP RLIIRKVDKQ TALLDADDPV SQLHKCAFYL KDTERMYLCL SQERIIQFQA TPCPKEPNKE MINDGASWTI ISTDKAEYTF YEGMGPVLAP VTPVPVVESL QLNGGGDVAM LELTGQNFTP NLRVWFGDVE AETMYRCGES MLCVVPDISA FREGWRWVRQ PVQVPVTLVR NDGIIYSTSL TFTYTPEPGP RPHCSAAGAI LRANSSQVPP NESNTNSEGS YTNASTNSTS VTSSTATVVS
Database document:
This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.