RBPJ | ENSG00000168214 | NCBI 3516

Details for: RBPJ

Gene ID: 3516

Symbol: RBPJ

Ensembl ID: ENSG00000168214

Description: recombination signal binding protein for immunoglobulin kappa J region

Associated with

Constitutive signaling by notch1 hd+pest domain mutants
(R-HSA-2894862)
Constitutive signaling by notch1 pest domain mutants
(R-HSA-2644606)
Developmental biology
(R-HSA-1266738)
Disease
(R-HSA-1643685)
Diseases of signal transduction by growth factor receptors and second messengers
(R-HSA-5663202)
Formation of paraxial mesoderm
(R-HSA-9793380)
Gastrulation
(R-HSA-9758941)
Gene expression (transcription)
(R-HSA-74160)
Generic transcription pathway
(R-HSA-212436)
Notch-hlh transcription pathway
(R-HSA-350054)
Notch1 intracellular domain regulates transcription
(R-HSA-2122947)
Notch2 intracellular domain regulates transcription
(R-HSA-2197563)
Notch3 intracellular domain regulates transcription
(R-HSA-9013508)
Notch4 intracellular domain regulates transcription
(R-HSA-9013695)
Pre-notch expression and processing
(R-HSA-1912422)
Pre-notch transcription and translation
(R-HSA-1912408)
Regulation of beta-cell development
(R-HSA-186712)
Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells
(R-HSA-210744)
Rna polymerase ii transcription
(R-HSA-73857)
Runx3 regulates notch signaling
(R-HSA-8941856)
Signaling by notch
(R-HSA-157118)
Signaling by notch1
(R-HSA-1980143)
Signaling by notch1 hd+pest domain mutants in cancer
(R-HSA-2894858)
Signaling by notch1 in cancer
(R-HSA-2644603)
Signaling by notch1 pest domain mutants in cancer
(R-HSA-2644602)
Signaling by notch2
(R-HSA-1980145)
Signaling by notch3
(R-HSA-9012852)
Signaling by notch4
(R-HSA-9013694)
Signal transduction
(R-HSA-162582)
Transcriptional regulation by runx3
(R-HSA-8878159)
Angiogenesis
(GO:0001525)
Aortic valve development
(GO:0003176)
Arterial endothelial cell fate commitment
(GO:0060844)
Atrioventricular canal development
(GO:0036302)
Auditory receptor cell fate commitment
(GO:0009912)
B cell differentiation
(GO:0030183)
Blood vessel endothelial cell fate specification
(GO:0097101)
Blood vessel lumenization
(GO:0072554)
Blood vessel remodeling
(GO:0001974)
Cardiac left ventricle morphogenesis
(GO:0003214)
Cardiac muscle cell myoblast differentiation
(GO:0060379)
Chromatin binding
(GO:0003682)
Club cell differentiation
(GO:0060486)
Defense response to bacterium
(GO:0042742)
Dna-binding transcription activator activity, rna polymerase ii-specific
(GO:0001228)
Dna-binding transcription factor activity
(GO:0003700)
Dna-binding transcription factor activity, rna polymerase ii-specific
(GO:0000981)
Dna-binding transcription factor binding
(GO:0140297)
Dna binding
(GO:0003677)
Dorsal aorta morphogenesis
(GO:0035912)
Endocardium morphogenesis
(GO:0003160)
Epidermal cell fate specification
(GO:0009957)
Epithelial cell proliferation
(GO:0050673)
Epithelial to mesenchymal transition
(GO:0001837)
Epithelial to mesenchymal transition involved in endocardial cushion formation
(GO:0003198)
Hair follicle maturation
(GO:0048820)
Heart development
(GO:0007507)
Humoral immune response
(GO:0006959)
Inflammatory response to antigenic stimulus
(GO:0002437)
Keratinocyte differentiation
(GO:0030216)
Labyrinthine layer blood vessel development
(GO:0060716)
Myeloid dendritic cell differentiation
(GO:0043011)
Negative regulation of cell differentiation
(GO:0045596)
Negative regulation of cold-induced thermogenesis
(GO:0120163)
Negative regulation of dna-templated transcription
(GO:0045892)
Negative regulation of ossification
(GO:0030279)
Negative regulation of transcription by rna polymerase ii
(GO:0000122)
Notch signaling pathway
(GO:0007219)
Outflow tract morphogenesis
(GO:0003151)
Pituitary gland development
(GO:0021983)
Positive regulation of bmp signaling pathway
(GO:0030513)
Positive regulation of canonical wnt signaling pathway
(GO:0090263)
Positive regulation of cardiac muscle cell proliferation
(GO:0060045)
Positive regulation of epithelial cell proliferation
(GO:0050679)
Positive regulation of gene expression
(GO:0010628)
Positive regulation of transcription by rna polymerase ii
(GO:0045944)
Positive regulation of transcription of notch receptor target
(GO:0007221)
Protein binding
(GO:0005515)
Pulmonary valve development
(GO:0003177)
Regulation of cell adhesion involved in heart morphogenesis
(GO:0061344)
Regulation of generation of precursor metabolites and energy
(GO:0043467)
Regulation of timing of cell differentiation
(GO:0048505)
Regulation of transcription by rna polymerase ii
(GO:0006357)
Rna polymerase ii-specific dna-binding transcription factor binding
(GO:0061629)
Rna polymerase ii cis-regulatory region sequence-specific dna binding
(GO:0000978)
Sebaceous gland development
(GO:0048733)
Secondary heart field specification
(GO:0003139)
Sequence-specific dna binding
(GO:0043565)
Somatic stem cell population maintenance
(GO:0035019)
Somitogenesis
(GO:0001756)
Stem cell proliferation
(GO:0072089)
Ventricular septum morphogenesis
(GO:0060412)
Ventricular trabecula myocardium morphogenesis
(GO:0003222)

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: acinar cell (CL0000622)
Fold Change: 3.39
Marker Score: 2,388
Cell Name: oligodendrocyte (CL0000128)
Fold Change: 3.09
Marker Score: 7,406
Cell Name: lung macrophage (CL1001603)
Fold Change: 2.87
Marker Score: 3,281
Cell Name: myeloid leukocyte (CL0000766)
Fold Change: 2.71
Marker Score: 3,276
Cell Name: lens epithelial cell (CL0002224)
Fold Change: 2.6
Marker Score: 3,147
Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
Fold Change: 2.55
Marker Score: 142,840
Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: 2.45
Marker Score: 10,260
Cell Name: fibroblast of mammary gland (CL0002555)
Fold Change: 2.43
Marker Score: 82,756
Cell Name: anterior lens cell (CL0002223)
Fold Change: 2.37
Marker Score: 3,184
Cell Name: corneal endothelial cell (CL0000132)
Fold Change: 2.22
Marker Score: 1,294
Cell Name: secondary lens fiber (CL0002225)
Fold Change: 2.17
Marker Score: 1,270
Cell Name: Hofbauer cell (CL3000001)
Fold Change: 2.15
Marker Score: 1,183
Cell Name: rod bipolar cell (CL0000751)
Fold Change: 2.15
Marker Score: 1,122
Cell Name: sst GABAergic cortical interneuron (CL4023017)
Fold Change: 2.11
Marker Score: 42,016
Cell Name: alveolar macrophage (CL0000583)
Fold Change: 2.09
Marker Score: 53,442
Cell Name: oligodendrocyte precursor cell (CL0002453)
Fold Change: 2.08
Marker Score: 2,571
Cell Name: ciliary muscle cell (CL1000443)
Fold Change: 2.07
Marker Score: 4,538
Cell Name: uterine smooth muscle cell (CL0002601)
Fold Change: 2.05
Marker Score: 2,667
Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
Fold Change: 2.04
Marker Score: 1,198
Cell Name: mesodermal cell (CL0000222)
Fold Change: 2.02
Marker Score: 26,701
Cell Name: myofibroblast cell (CL0000186)
Fold Change: 2.01
Marker Score: 2,481
Cell Name: exhausted T cell (CL0011025)
Fold Change: 1.99
Marker Score: 1,143
Cell Name: photoreceptor cell (CL0000210)
Fold Change: 1.98
Marker Score: 1,493
Cell Name: vascular leptomeningeal cell (CL4023051)
Fold Change: 1.98
Marker Score: 2,274
Cell Name: keratocyte (CL0002363)
Fold Change: 1.97
Marker Score: 454
Cell Name: CD14-positive monocyte (CL0001054)
Fold Change: 1.97
Marker Score: 4,895
Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: 1.96
Marker Score: 620
Cell Name: astrocyte of the cerebral cortex (CL0002605)
Fold Change: 1.95
Marker Score: 41,640
Cell Name: epithelial cell of nephron (CL1000449)
Fold Change: 1.94
Marker Score: 4,045
Cell Name: microglial cell (CL0000129)
Fold Change: 1.93
Marker Score: 3,511
Cell Name: mesenchymal cell (CL0008019)
Fold Change: 1.9
Marker Score: 3,231
Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
Fold Change: 1.86
Marker Score: 27,799
Cell Name: epithelial cell of lower respiratory tract (CL0002632)
Fold Change: 1.86
Marker Score: 7,751
Cell Name: secretory cell (CL0000151)
Fold Change: 1.86
Marker Score: 3,387
Cell Name: fibroblast of breast (CL4006000)
Fold Change: 1.84
Marker Score: 1,052
Cell Name: stromal cell (CL0000499)
Fold Change: 1.84
Marker Score: 2,153
Cell Name: vip GABAergic cortical interneuron (CL4023016)
Fold Change: 1.83
Marker Score: 69,615
Cell Name: CD1c-positive myeloid dendritic cell (CL0002399)
Fold Change: 1.83
Marker Score: 4,742
Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: 1.82
Marker Score: 111,779
Cell Name: mature microglial cell (CL0002629)
Fold Change: 1.82
Marker Score: 656
Cell Name: dopaminergic neuron (CL0000700)
Fold Change: 1.81
Marker Score: 18,700
Cell Name: corneal epithelial cell (CL0000575)
Fold Change: 1.81
Marker Score: 1,997
Cell Name: basal cell (CL0000646)
Fold Change: 1.81
Marker Score: 2,333
Cell Name: conjunctival epithelial cell (CL1000432)
Fold Change: 1.8
Marker Score: 1,896
Cell Name: mesenchymal stem cell (CL0000134)
Fold Change: 1.79
Marker Score: 2,759
Cell Name: respiratory goblet cell (CL0002370)
Fold Change: 1.79
Marker Score: 516
Cell Name: oogonial cell (CL0000024)
Fold Change: 1.78
Marker Score: 2,559
Cell Name: skeletal muscle satellite stem cell (CL0008011)
Fold Change: 1.77
Marker Score: 1,887
Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
Fold Change: 1.76
Marker Score: 1,902
Cell Name: enteric smooth muscle cell (CL0002504)
Fold Change: 1.76
Marker Score: 4,150
Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
Fold Change: 1.76
Marker Score: 64,818
Cell Name: Kupffer cell (CL0000091)
Fold Change: 1.75
Marker Score: 1,754
Cell Name: luminal epithelial cell of mammary gland (CL0002326)
Fold Change: 1.75
Marker Score: 3,105
Cell Name: supporting cell (CL0000630)
Fold Change: 1.75
Marker Score: 3,282
Cell Name: hematopoietic cell (CL0000988)
Fold Change: 1.75
Marker Score: 1,160
Cell Name: microfold cell of epithelium of small intestine (CL1000353)
Fold Change: 1.73
Marker Score: 414
Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
Fold Change: 1.73
Marker Score: 16,289
Cell Name: sncg GABAergic cortical interneuron (CL4023015)
Fold Change: 1.72
Marker Score: 13,198
Cell Name: myelocyte (CL0002193)
Fold Change: 1.71
Marker Score: 738
Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: 1.7
Marker Score: 498
Cell Name: melanocyte (CL0000148)
Fold Change: 1.7
Marker Score: 689
Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
Fold Change: 1.69
Marker Score: 1,061
Cell Name: epicardial adipocyte (CL1000309)
Fold Change: 1.69
Marker Score: 820
Cell Name: astrocyte (CL0000127)
Fold Change: 1.69
Marker Score: 1,462
Cell Name: neuron (CL0000540)
Fold Change: 1.68
Marker Score: 6,854
Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
Fold Change: 1.68
Marker Score: 15,978
Cell Name: bladder urothelial cell (CL1001428)
Fold Change: 1.68
Marker Score: 2,475
Cell Name: granulosa cell (CL0000501)
Fold Change: 1.67
Marker Score: 16,850
Cell Name: kidney interstitial fibroblast (CL1000692)
Fold Change: 1.67
Marker Score: 3,220
Cell Name: CD14-positive, CD16-positive monocyte (CL0002397)
Fold Change: 1.67
Marker Score: 3,252
Cell Name: bronchus fibroblast of lung (CL2000093)
Fold Change: 1.67
Marker Score: 2,295
Cell Name: chromaffin cell (CL0000166)
Fold Change: 1.67
Marker Score: 2,346
Cell Name: neural crest cell (CL0011012)
Fold Change: 1.67
Marker Score: 1,780
Cell Name: adventitial cell (CL0002503)
Fold Change: 1.66
Marker Score: 411
Cell Name: decidual cell (CL2000002)
Fold Change: 1.66
Marker Score: 7,146
Cell Name: choroid plexus epithelial cell (CL0000706)
Fold Change: 1.66
Marker Score: 1,522
Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: 1.66
Marker Score: 6,399
Cell Name: cerebellar granule cell precursor (CL0002362)
Fold Change: 1.65
Marker Score: 927
Cell Name: placental villous trophoblast (CL2000060)
Fold Change: 1.65
Marker Score: 6,493
Cell Name: reticular cell (CL0000432)
Fold Change: 1.65
Marker Score: 602
Cell Name: neutrophil (CL0000775)
Fold Change: 1.64
Marker Score: 1,001
Cell Name: Bergmann glial cell (CL0000644)
Fold Change: 1.64
Marker Score: 669
Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
Fold Change: 1.64
Marker Score: 10,474
Cell Name: elicited macrophage (CL0000861)
Fold Change: 1.64
Marker Score: 9,952
Cell Name: kidney epithelial cell (CL0002518)
Fold Change: 1.62
Marker Score: 1,717
Cell Name: stromal cell of ovary (CL0002132)
Fold Change: 1.62
Marker Score: 18,269
Cell Name: neuron associated cell (sensu Vertebrata) (CL0000123)
Fold Change: 1.62
Marker Score: 8,493
Cell Name: smooth muscle cell of prostate (CL1000487)
Fold Change: 1.61
Marker Score: 411
Cell Name: club cell (CL0000158)
Fold Change: 1.61
Marker Score: 1,881
Cell Name: primordial germ cell (CL0000670)
Fold Change: 1.61
Marker Score: 2,020
Cell Name: lactocyte (CL0002325)
Fold Change: 1.61
Marker Score: 25,789
Cell Name: professional antigen presenting cell (CL0000145)
Fold Change: 1.6
Marker Score: 828
Cell Name: activated CD8-positive, alpha-beta T cell, human (CL0001049)
Fold Change: 1.6
Marker Score: 364
Cell Name: L6b glutamatergic cortical neuron (CL4023038)
Fold Change: 1.59
Marker Score: 13,673
Cell Name: respiratory epithelial cell (CL0002368)
Fold Change: 1.59
Marker Score: 876
Cell Name: podocyte (CL0000653)
Fold Change: 1.58
Marker Score: 586
Cell Name: fibroblast of lung (CL0002553)
Fold Change: 1.58
Marker Score: 4,139
Cell Name: fibroblast (CL0000057)
Fold Change: 1.58
Marker Score: 1,523
Cell Name: erythroblast (CL0000765)
Fold Change: 1.58
Marker Score: 984
Cell Name: radial glial cell (CL0000681)
Fold Change: 1.57
Marker Score: 580

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

**Key Characteristics** RBPJ is a member of the Notch family of transcription factors, which are characterized by their ability to regulate cell fate decisions, proliferation, and differentiation. RBPJ is specifically involved in the recombination signal binding process, which is essential for the correct joining of immunoglobulin heavy and light chain genes in B cells. Its unique structure, consisting of an N-terminal domain and a C-terminal HD domain, allows it to interact with other Notch receptors and co-receptors, triggering the Notch signaling pathway. **Pathways and Functions** RBPJ is involved in various signaling pathways, including: 1. Notch signaling pathway: RBPJ is the primary ligand for Notch receptors, triggering the activation of downstream signaling molecules, such as RBP-J (also known as CBF1) and CBF1-RAP1. 2. Wnt signaling pathway: RBPJ can interact with Wnt proteins, influencing cell proliferation and differentiation. 3. TGF-β signaling pathway: RBPJ has been shown to regulate TGF-β signaling, affecting cell differentiation and proliferation. 4. Notch-hlh transcription pathway: RBPJ can regulate the expression of Notch-hlh target genes, influencing cell fate decisions. RBPJ's functions include: 1. B cell development and maturation: RBPJ is essential for the correct joining of immunoglobulin heavy and light chain genes, ensuring the proper development and maturation of B cells. 2. Immune tolerance: RBPJ can regulate the expression of immune suppressive genes, influencing immune tolerance and preventing autoimmune responses. 3. Tissue development: RBPJ is involved in the development of various tissues, including the heart, lungs, and skin. 4. Cancer development: RBPJ has been implicated in the development and progression of various cancers, including leukemia and lymphoma. **Clinical Significance** Dysregulation of RBPJ has been implicated in various diseases, including: 1. Immunodeficiency disorders: Mutations in RBPJ can lead to impaired B cell development and function, resulting in immunodeficiency disorders. 2. Cancer: RBPJ overexpression or aberrant signaling has been linked to cancer development and progression. 3. Autoimmune diseases: RBPJ can influence immune tolerance, and its dysregulation has been implicated in autoimmune diseases, such as rheumatoid arthritis and lupus. 4. Congenital heart defects: RBPJ has been shown to play a role in heart development, and its dysregulation can lead to congenital heart defects. In conclusion, RBPJ is a crucial transcription factor involved in the development and function of various tissues and organs, including the immune system. Its dysregulation can lead to various diseases, highlighting the importance of understanding its role in normal and pathological processes.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

Recombining binding protein suppressor of hairless

Genular Protein ID: 2136746154

Symbol: SUH_HUMAN

Name: Recombining binding protein suppressor of hairless

UniProtKB Accession Codes:

Q06330 B4DY22 Q5XKH9 Q6P1N3

Database IDs:

Citations:

PubMed ID: 8406481

Title: Human Jk recombination signal binding protein gene (IGKJRB): comparison with its mouse homologue.

PubMed ID: 8406481

DOI: 10.1006/geno.1993.1326

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15815621

Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.

PubMed ID: 15815621

DOI: 10.1038/nature03466

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8016657

Title: Mediation of Epstein-Barr virus EBNA2 transactivation by recombination signal-binding protein J kappa.

PubMed ID: 8016657

DOI: 10.1126/science.8016657

PubMed ID: 8627785

Title: The amino-terminal domains of Epstein-Barr virus nuclear proteins 3A, 3B, and 3C interact with RBPJ(kappa).

PubMed ID: 8627785

DOI: 10.1128/jvi.70.5.3068-3074.1996

PubMed ID: 10508479

Title: Antigens recognized by autologous antibody in patients with renal-cell carcinoma.

PubMed ID: 10508479

DOI: 10.1002/(sici)1097-0215(19991112)83:4<456::aid-ijc4>3.0.co;2-5

PubMed ID: 9874765

Title: CIR, a corepressor linking the DNA binding factor CBF1 to the histone deacetylase complex.

PubMed ID: 9874765

DOI: 10.1073/pnas.96.1.23

PubMed ID: 10644367

Title: A role for SKIP in EBNA2 activation of CBF1-repressed promoters.

PubMed ID: 10644367

DOI: 10.1128/jvi.74.4.1939-1947.2000

PubMed ID: 10637481

Title: Intracellular forms of human NOTCH1 interact at distinctly different levels with RBP-jkappa in human B and T cells.

PubMed ID: 10637481

DOI: 10.1038/sj.leu.2401630

PubMed ID: 12374742

Title: SHARP is a novel component of the Notch/RBP-Jkappa signalling pathway.

PubMed ID: 12374742

DOI: 10.1093/emboj/cdf549

PubMed ID: 21102556

Title: RITA, a novel modulator of Notch signalling, acts via nuclear export of RBP-J.

PubMed ID: 21102556

DOI: 10.1038/emboj.2010.289

PubMed ID: 21991380

Title: A SILAC-based screen for Methyl-CpG binding proteins identifies RBP-J as a DNA methylation and sequence-specific binding protein.

PubMed ID: 21991380

DOI: 10.1371/journal.pone.0025884

PubMed ID: 23571214

Title: BEND6 is a nuclear antagonist of Notch signaling during self-renewal of neural stem cells.

PubMed ID: 23571214

DOI: 10.1242/dev.087502

PubMed ID: 23303788

Title: Oxygen-dependent expression of cytochrome c oxidase subunit 4-2 gene expression is mediated by transcription factors RBPJ, CXXC5 and CHCHD2.

PubMed ID: 23303788

DOI: 10.1093/nar/gks1454

PubMed ID: 26522984

Title: The PIAS-like coactivator Zmiz1 is a direct and selective cofactor of Notch1 in T cell development and leukemia.

PubMed ID: 26522984

DOI: 10.1016/j.immuni.2015.10.007

PubMed ID: 29030483

Title: RBPJ/CBF1 interacts with L3MBTL3/MBT1 to promote repression of Notch signaling via histone demethylase KDM1A/LSD1.

PubMed ID: 29030483

DOI: 10.15252/embj.201796525

PubMed ID: 16530044

Title: Structural basis for cooperativity in recruitment of MAML coactivators to Notch transcription complexes.

PubMed ID: 16530044

DOI: 10.1016/j.cell.2005.12.037

PubMed ID: 22883147

Title: RBPJ mutations identified in two families affected by Adams-Oliver syndrome.

PubMed ID: 22883147

DOI: 10.1016/j.ajhg.2012.07.005

Sequence Information:

Length: 500
Mass: 55637
Checksum: 91E50D2DE9087EDA
Sequence:

MDHTEGSPAE EPPAHAPSPG KFGERPPPKR LTREAMRNYL KERGDQTVLI LHAKVAQKSY 
GNEKRFFCPP PCVYLMGSGW KKKKEQMERD GCSEQESQPC AFIGIGNSDQ EMQQLNLEGK 
NYCTAKTLYI SDSDKRKHFM LSVKMFYGNS DDIGVFLSKR IKVISKPSKK KQSLKNADLC 
IASGTKVALF NRLRSQTVST RYLHVEGGNF HASSQQWGAF FIHLLDDDES EGEEFTVRDG 
YIHYGQTVKL VCSVTGMALP RLIIRKVDKQ TALLDADDPV SQLHKCAFYL KDTERMYLCL 
SQERIIQFQA TPCPKEPNKE MINDGASWTI ISTDKAEYTF YEGMGPVLAP VTPVPVVESL 
QLNGGGDVAM LELTGQNFTP NLRVWFGDVE AETMYRCGES MLCVVPDISA FREGWRWVRQ 
PVQVPVTLVR NDGIIYSTSL TFTYTPEPGP RPHCSAAGAI LRANSSQVPP NESNTNSEGS 
YTNASTNSTS VTSSTATVVS

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: RBPJ

Associated with

Cells (max top 100)

Other Information

Human Jk recombination signal binding protein gene (IGKJRB): comparison with its mouse homologue. PubMed ID: 8406481

Complete sequencing and characterization of 21,243 full-length human cDNAs. PubMed ID: 14702039

Generation and annotation of the DNA sequences of human chromosomes 2 and 4. PubMed ID: 15815621

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Mediation of Epstein-Barr virus EBNA2 transactivation by recombination signal-binding protein J kappa. PubMed ID: 8016657

The amino-terminal domains of Epstein-Barr virus nuclear proteins 3A, 3B, and 3C interact with RBPJ(kappa). PubMed ID: 8627785

Antigens recognized by autologous antibody in patients with renal-cell carcinoma. PubMed ID: 10508479

CIR, a corepressor linking the DNA binding factor CBF1 to the histone deacetylase complex. PubMed ID: 9874765

A role for SKIP in EBNA2 activation of CBF1-repressed promoters. PubMed ID: 10644367

Intracellular forms of human NOTCH1 interact at distinctly different levels with RBP-jkappa in human B and T cells. PubMed ID: 10637481

SHARP is a novel component of the Notch/RBP-Jkappa signalling pathway. PubMed ID: 12374742

RITA, a novel modulator of Notch signalling, acts via nuclear export of RBP-J. PubMed ID: 21102556

A SILAC-based screen for Methyl-CpG binding proteins identifies RBP-J as a DNA methylation and sequence-specific binding protein. PubMed ID: 21991380

BEND6 is a nuclear antagonist of Notch signaling during self-renewal of neural stem cells. PubMed ID: 23571214

Oxygen-dependent expression of cytochrome c oxidase subunit 4-2 gene expression is mediated by transcription factors RBPJ, CXXC5 and CHCHD2. PubMed ID: 23303788

The PIAS-like coactivator Zmiz1 is a direct and selective cofactor of Notch1 in T cell development and leukemia. PubMed ID: 26522984

RBPJ/CBF1 interacts with L3MBTL3/MBT1 to promote repression of Notch signaling via histone demethylase KDM1A/LSD1. PubMed ID: 29030483

Structural basis for cooperativity in recruitment of MAML coactivators to Notch transcription complexes. PubMed ID: 16530044

RBPJ mutations identified in two families affected by Adams-Oliver syndrome. PubMed ID: 22883147