Details for: RBPJ

Gene ID: 3516

Symbol: RBPJ

Ensembl ID: ENSG00000168214

Description: recombination signal binding protein for immunoglobulin kappa J region

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: acinar cell (CL0000622)
    Fold Change: 3.39
    Marker Score: 2388
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: 3.09
    Marker Score: 7406
  • Cell Name: lung macrophage (CL1001603)
    Fold Change: 2.87
    Marker Score: 3281
  • Cell Name: myeloid leukocyte (CL0000766)
    Fold Change: 2.71
    Marker Score: 3276
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 2.6
    Marker Score: 3147
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 2.55
    Marker Score: 142840
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 2.45
    Marker Score: 10259.5
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 2.43
    Marker Score: 82756
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 2.37
    Marker Score: 3184
  • Cell Name: corneal endothelial cell (CL0000132)
    Fold Change: 2.22
    Marker Score: 1294
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 2.17
    Marker Score: 1270
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: 2.15
    Marker Score: 1183
  • Cell Name: rod bipolar cell (CL0000751)
    Fold Change: 2.15
    Marker Score: 1122
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 2.11
    Marker Score: 42016
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: 2.09
    Marker Score: 53442
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: 2.08
    Marker Score: 2571
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 2.07
    Marker Score: 4537.5
  • Cell Name: uterine smooth muscle cell (CL0002601)
    Fold Change: 2.05
    Marker Score: 2667
  • Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
    Fold Change: 2.04
    Marker Score: 1197.5
  • Cell Name: mesodermal cell (CL0000222)
    Fold Change: 2.02
    Marker Score: 26701
  • Cell Name: myofibroblast cell (CL0000186)
    Fold Change: 2.01
    Marker Score: 2480.5
  • Cell Name: exhausted T cell (CL0011025)
    Fold Change: 1.99
    Marker Score: 1143
  • Cell Name: photoreceptor cell (CL0000210)
    Fold Change: 1.98
    Marker Score: 1492.5
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: 1.98
    Marker Score: 2274
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 1.97
    Marker Score: 454
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: 1.97
    Marker Score: 4895
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: 1.96
    Marker Score: 619.5
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 1.95
    Marker Score: 41640
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: 1.94
    Marker Score: 4045
  • Cell Name: microglial cell (CL0000129)
    Fold Change: 1.93
    Marker Score: 3511
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 1.9
    Marker Score: 3231
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: 1.86
    Marker Score: 27799
  • Cell Name: epithelial cell of lower respiratory tract (CL0002632)
    Fold Change: 1.86
    Marker Score: 7751
  • Cell Name: secretory cell (CL0000151)
    Fold Change: 1.86
    Marker Score: 3387
  • Cell Name: fibroblast of breast (CL4006000)
    Fold Change: 1.84
    Marker Score: 1052
  • Cell Name: stromal cell (CL0000499)
    Fold Change: 1.84
    Marker Score: 2153
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 1.83
    Marker Score: 69615
  • Cell Name: CD1c-positive myeloid dendritic cell (CL0002399)
    Fold Change: 1.83
    Marker Score: 4742
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.82
    Marker Score: 111779
  • Cell Name: mature microglial cell (CL0002629)
    Fold Change: 1.82
    Marker Score: 656
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 1.81
    Marker Score: 18700
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 1.81
    Marker Score: 1997
  • Cell Name: basal cell (CL0000646)
    Fold Change: 1.81
    Marker Score: 2333
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 1.8
    Marker Score: 1896
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: 1.79
    Marker Score: 2759
  • Cell Name: respiratory goblet cell (CL0002370)
    Fold Change: 1.79
    Marker Score: 516
  • Cell Name: oogonial cell (CL0000024)
    Fold Change: 1.78
    Marker Score: 2559
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: 1.77
    Marker Score: 1887
  • Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
    Fold Change: 1.76
    Marker Score: 1902
  • Cell Name: enteric smooth muscle cell (CL0002504)
    Fold Change: 1.76
    Marker Score: 4150
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 1.76
    Marker Score: 64818
  • Cell Name: Kupffer cell (CL0000091)
    Fold Change: 1.75
    Marker Score: 1754
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: 1.75
    Marker Score: 3105
  • Cell Name: supporting cell (CL0000630)
    Fold Change: 1.75
    Marker Score: 3282
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: 1.75
    Marker Score: 1160
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 1.73
    Marker Score: 414
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 1.73
    Marker Score: 16289
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: 1.72
    Marker Score: 13198
  • Cell Name: myelocyte (CL0002193)
    Fold Change: 1.71
    Marker Score: 738
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 1.7
    Marker Score: 498
  • Cell Name: melanocyte (CL0000148)
    Fold Change: 1.7
    Marker Score: 689
  • Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
    Fold Change: 1.69
    Marker Score: 1061
  • Cell Name: epicardial adipocyte (CL1000309)
    Fold Change: 1.69
    Marker Score: 820
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 1.69
    Marker Score: 1462
  • Cell Name: neuron (CL0000540)
    Fold Change: 1.68
    Marker Score: 6854
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 1.68
    Marker Score: 15978
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.68
    Marker Score: 2475
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 1.67
    Marker Score: 16850
  • Cell Name: kidney interstitial fibroblast (CL1000692)
    Fold Change: 1.67
    Marker Score: 3220
  • Cell Name: CD14-positive, CD16-positive monocyte (CL0002397)
    Fold Change: 1.67
    Marker Score: 3252
  • Cell Name: bronchus fibroblast of lung (CL2000093)
    Fold Change: 1.67
    Marker Score: 2294.5
  • Cell Name: chromaffin cell (CL0000166)
    Fold Change: 1.67
    Marker Score: 2346
  • Cell Name: neural crest cell (CL0011012)
    Fold Change: 1.67
    Marker Score: 1780
  • Cell Name: adventitial cell (CL0002503)
    Fold Change: 1.66
    Marker Score: 411
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 1.66
    Marker Score: 7146
  • Cell Name: choroid plexus epithelial cell (CL0000706)
    Fold Change: 1.66
    Marker Score: 1522
  • Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 1.66
    Marker Score: 6399
  • Cell Name: cerebellar granule cell precursor (CL0002362)
    Fold Change: 1.65
    Marker Score: 927
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 1.65
    Marker Score: 6493
  • Cell Name: reticular cell (CL0000432)
    Fold Change: 1.65
    Marker Score: 602
  • Cell Name: neutrophil (CL0000775)
    Fold Change: 1.64
    Marker Score: 1001
  • Cell Name: Bergmann glial cell (CL0000644)
    Fold Change: 1.64
    Marker Score: 669
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 1.64
    Marker Score: 10474
  • Cell Name: elicited macrophage (CL0000861)
    Fold Change: 1.64
    Marker Score: 9951.5
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: 1.62
    Marker Score: 1717
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 1.62
    Marker Score: 18269
  • Cell Name: neuron associated cell (sensu Vertebrata) (CL0000123)
    Fold Change: 1.62
    Marker Score: 8493
  • Cell Name: smooth muscle cell of prostate (CL1000487)
    Fold Change: 1.61
    Marker Score: 411
  • Cell Name: club cell (CL0000158)
    Fold Change: 1.61
    Marker Score: 1881
  • Cell Name: primordial germ cell (CL0000670)
    Fold Change: 1.61
    Marker Score: 2020
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 1.61
    Marker Score: 25789
  • Cell Name: professional antigen presenting cell (CL0000145)
    Fold Change: 1.6
    Marker Score: 828
  • Cell Name: activated CD8-positive, alpha-beta T cell, human (CL0001049)
    Fold Change: 1.6
    Marker Score: 364
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 1.59
    Marker Score: 13673
  • Cell Name: respiratory epithelial cell (CL0002368)
    Fold Change: 1.59
    Marker Score: 876
  • Cell Name: podocyte (CL0000653)
    Fold Change: 1.58
    Marker Score: 585.5
  • Cell Name: fibroblast of lung (CL0002553)
    Fold Change: 1.58
    Marker Score: 4139
  • Cell Name: fibroblast (CL0000057)
    Fold Change: 1.58
    Marker Score: 1523
  • Cell Name: erythroblast (CL0000765)
    Fold Change: 1.58
    Marker Score: 984
  • Cell Name: radial glial cell (CL0000681)
    Fold Change: 1.57
    Marker Score: 580

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Other Information

**Key characteristics:** - RBPJ is a transmembrane protein with a molecular weight of approximately 120 kDa. - It is a key component of the Notch signaling pathway. - It is expressed in a variety of cell types during embryonic development. - It is involved in the regulation of epithelial cell fate, including the specification of mesoderm and the development of tissues such as the pancreas and lungs. - It is a key regulator of Notch1, Notch2, Notch3, and Notch4 signaling pathways. **Pathways and functions:** - RBPJ is a key component of the Notch signaling pathway, which is a major regulator of epithelial cell fate in the developing embryo. - The Notch signaling pathway is a complex network of signaling molecules that interact with each other to regulate cell fate. - RBPJ is a key component of the Notch signaling pathway, and it is involved in the regulation of epithelial cell fate by interacting with Notch1, Notch2, Notch3, and Notch4 signaling proteins. - RBPJ is also involved in the regulation of gene expression in late-stage (branching morphogenesis) pancreatic bud precursor cells. **Clinical significance:** - Mutations in RBPJ have been linked to a number of human diseases, including cancer and developmental disorders. - Understanding the role of RBPJ in the Notch signaling pathway has potential implications for the development of new therapies for cancer and other diseases that are caused by defects in this pathway.

Genular Protein ID: 2136746154

Symbol: SUH_HUMAN

Name: Recombining binding protein suppressor of hairless

UniProtKB Accession Codes:

Q06330 B4DY22 Q5XKH9 Q6P1N3

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 4 CDD 1 CORUM 1 CTD 1 ChEMBL 1 ChiTaRS 1 ComplexPortal 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 ELM 1 EMBL 12 EPD 1 Ensembl 14 EvolutionaryTrace 1 ExpressionAtlas 1 GO 74 Gene3D 3 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 2 HOGENOM 1 HPA 1 IDEAL 1 InParanoid 1 IntAct 1 InterPro 9 KEGG 1 MANE-Select 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PDB 6 PDBsum 4 PIR 1 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 3 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 7 Pumba 1 RNAct 1 Reactome 12 RefSeq 10 SAM 1 SIGNOR 1 SMART 2 SMR 1 STRING 1 SUPFAM 3 SignaLink 1 TopDownProteomics 1 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8406481

Title: Human Jk recombination signal binding protein gene (IGKJRB): comparison with its mouse homologue.

PubMed ID: 8406481

DOI: 10.1006/geno.1993.1326

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15815621

Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.

PubMed ID: 15815621

DOI: 10.1038/nature03466

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8016657

Title: Mediation of Epstein-Barr virus EBNA2 transactivation by recombination signal-binding protein J kappa.

PubMed ID: 8016657

DOI: 10.1126/science.8016657

PubMed ID: 8627785

Title: The amino-terminal domains of Epstein-Barr virus nuclear proteins 3A, 3B, and 3C interact with RBPJ(kappa).

PubMed ID: 8627785

DOI: 10.1128/jvi.70.5.3068-3074.1996

PubMed ID: 10508479

Title: Antigens recognized by autologous antibody in patients with renal-cell carcinoma.

PubMed ID: 10508479

DOI: 10.1002/(sici)1097-0215(19991112)83:4<456::aid-ijc4>3.0.co;2-5

PubMed ID: 9874765

Title: CIR, a corepressor linking the DNA binding factor CBF1 to the histone deacetylase complex.

PubMed ID: 9874765

DOI: 10.1073/pnas.96.1.23

PubMed ID: 10644367

Title: A role for SKIP in EBNA2 activation of CBF1-repressed promoters.

PubMed ID: 10644367

DOI: 10.1128/jvi.74.4.1939-1947.2000

PubMed ID: 10637481

Title: Intracellular forms of human NOTCH1 interact at distinctly different levels with RBP-jkappa in human B and T cells.

PubMed ID: 10637481

DOI: 10.1038/sj.leu.2401630

PubMed ID: 12374742

Title: SHARP is a novel component of the Notch/RBP-Jkappa signalling pathway.

PubMed ID: 12374742

DOI: 10.1093/emboj/cdf549

PubMed ID: 21102556

Title: RITA, a novel modulator of Notch signalling, acts via nuclear export of RBP-J.

PubMed ID: 21102556

DOI: 10.1038/emboj.2010.289

PubMed ID: 21991380

Title: A SILAC-based screen for Methyl-CpG binding proteins identifies RBP-J as a DNA methylation and sequence-specific binding protein.

PubMed ID: 21991380

DOI: 10.1371/journal.pone.0025884

PubMed ID: 23571214

Title: BEND6 is a nuclear antagonist of Notch signaling during self-renewal of neural stem cells.

PubMed ID: 23571214

DOI: 10.1242/dev.087502

PubMed ID: 23303788

Title: Oxygen-dependent expression of cytochrome c oxidase subunit 4-2 gene expression is mediated by transcription factors RBPJ, CXXC5 and CHCHD2.

PubMed ID: 23303788

DOI: 10.1093/nar/gks1454

PubMed ID: 26522984

Title: The PIAS-like coactivator Zmiz1 is a direct and selective cofactor of Notch1 in T cell development and leukemia.

PubMed ID: 26522984

DOI: 10.1016/j.immuni.2015.10.007

PubMed ID: 29030483

Title: RBPJ/CBF1 interacts with L3MBTL3/MBT1 to promote repression of Notch signaling via histone demethylase KDM1A/LSD1.

PubMed ID: 29030483

DOI: 10.15252/embj.201796525

PubMed ID: 16530044

Title: Structural basis for cooperativity in recruitment of MAML coactivators to Notch transcription complexes.

PubMed ID: 16530044

DOI: 10.1016/j.cell.2005.12.037

PubMed ID: 22883147

Title: RBPJ mutations identified in two families affected by Adams-Oliver syndrome.

PubMed ID: 22883147

DOI: 10.1016/j.ajhg.2012.07.005

Sequence Information:

  • Length: 500
  • Mass: 55637
  • Checksum: 91E50D2DE9087EDA
  • Sequence:
    • MDHTEGSPAE EPPAHAPSPG KFGERPPPKR LTREAMRNYL KERGDQTVLI LHAKVAQKSY 
GNEKRFFCPP PCVYLMGSGW KKKKEQMERD GCSEQESQPC AFIGIGNSDQ EMQQLNLEGK 
NYCTAKTLYI SDSDKRKHFM LSVKMFYGNS DDIGVFLSKR IKVISKPSKK KQSLKNADLC 
IASGTKVALF NRLRSQTVST RYLHVEGGNF HASSQQWGAF FIHLLDDDES EGEEFTVRDG 
YIHYGQTVKL VCSVTGMALP RLIIRKVDKQ TALLDADDPV SQLHKCAFYL KDTERMYLCL 
SQERIIQFQA TPCPKEPNKE MINDGASWTI ISTDKAEYTF YEGMGPVLAP VTPVPVVESL 
QLNGGGDVAM LELTGQNFTP NLRVWFGDVE AETMYRCGES MLCVVPDISA FREGWRWVRQ 
PVQVPVTLVR NDGIIYSTSL TFTYTPEPGP RPHCSAAGAI LRANSSQVPP NESNTNSEGS 
YTNASTNSTS VTSSTATVVS

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.