Details for: WDPCP

Gene ID: 51057

Symbol: WDPCP

Ensembl ID: ENSG00000143951

Description: WD repeat containing planar cell polarity effector

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 389.0830
    Cell Significance Index: -60.5200
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 239.3518
    Cell Significance Index: -60.7100
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 125.1158
    Cell Significance Index: -59.0700
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 109.7827
    Cell Significance Index: -44.6000
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 49.2556
    Cell Significance Index: -60.7300
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 46.7560
    Cell Significance Index: -44.6400
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 21.1284
    Cell Significance Index: -56.6000
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 15.6334
    Cell Significance Index: -61.6900
  • Cell Name: adipocyte of breast (CL0002617)
    Fold Change: 11.9316
    Cell Significance Index: 150.2500
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 11.2630
    Cell Significance Index: -24.6500
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: 7.6084
    Cell Significance Index: 185.6400
  • Cell Name: type II muscle cell (CL0002212)
    Fold Change: 6.2497
    Cell Significance Index: 100.8400
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 4.4454
    Cell Significance Index: 341.1300
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: 3.8202
    Cell Significance Index: 74.5600
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 3.1289
    Cell Significance Index: 138.4000
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 3.0295
    Cell Significance Index: 114.7200
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 2.8365
    Cell Significance Index: 569.0000
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 2.5845
    Cell Significance Index: 145.0300
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 2.5287
    Cell Significance Index: 65.0000
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 2.4920
    Cell Significance Index: 167.5600
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 2.2207
    Cell Significance Index: 796.5200
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 2.1357
    Cell Significance Index: 35.9800
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 2.1046
    Cell Significance Index: 417.6600
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 1.9730
    Cell Significance Index: 121.2700
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: 1.9645
    Cell Significance Index: 56.0600
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: 1.8347
    Cell Significance Index: 44.0000
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 1.6296
    Cell Significance Index: 3068.3100
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: 1.1055
    Cell Significance Index: 7.4900
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 1.0023
    Cell Significance Index: 28.0100
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.9109
    Cell Significance Index: 630.0200
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.6919
    Cell Significance Index: 439.4600
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.6168
    Cell Significance Index: 117.3800
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: 0.5135
    Cell Significance Index: 53.4700
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.3570
    Cell Significance Index: 549.6500
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.3368
    Cell Significance Index: 621.1300
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.2799
    Cell Significance Index: 127.0400
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.2798
    Cell Significance Index: 252.6400
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.2764
    Cell Significance Index: 6.9100
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.2723
    Cell Significance Index: 17.1600
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.2396
    Cell Significance Index: 325.8400
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 0.1879
    Cell Significance Index: 3.2200
  • Cell Name: OFF midget ganglion cell (CL4033047)
    Fold Change: 0.1660
    Cell Significance Index: 2.0700
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.0705
    Cell Significance Index: 12.7100
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.0451
    Cell Significance Index: 4.4600
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: 0.0359
    Cell Significance Index: 0.5300
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.0116
    Cell Significance Index: 1.8900
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.0065
    Cell Significance Index: 3.5600
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.0046
    Cell Significance Index: 2.0300
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: -0.0181
    Cell Significance Index: -0.2600
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0415
    Cell Significance Index: -1.4600
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0593
    Cell Significance Index: -7.2900
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0664
    Cell Significance Index: -48.6500
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0719
    Cell Significance Index: -53.2700
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0875
    Cell Significance Index: -66.2200
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.0972
    Cell Significance Index: -2.8000
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.1085
    Cell Significance Index: -67.7800
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.1098
    Cell Significance Index: -61.9500
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.1290
    Cell Significance Index: -1.7600
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.1406
    Cell Significance Index: -20.4400
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: -0.1620
    Cell Significance Index: -2.3300
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.1670
    Cell Significance Index: -19.4600
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.1703
    Cell Significance Index: -49.0000
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: -0.1770
    Cell Significance Index: -19.2600
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.2141
    Cell Significance Index: -36.5600
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.2284
    Cell Significance Index: -31.3600
  • Cell Name: ON midget ganglion cell (CL4033046)
    Fold Change: -0.2527
    Cell Significance Index: -3.1900
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.2875
    Cell Significance Index: -13.0300
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.2977
    Cell Significance Index: -62.7000
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.3354
    Cell Significance Index: -43.0000
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.3358
    Cell Significance Index: -39.6000
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.3868
    Cell Significance Index: -49.9700
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: -0.4126
    Cell Significance Index: -6.0900
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.4291
    Cell Significance Index: -43.8400
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: -0.4491
    Cell Significance Index: -31.0600
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.4533
    Cell Significance Index: -9.6200
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.4605
    Cell Significance Index: -52.7600
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.4751
    Cell Significance Index: -29.1300
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.4817
    Cell Significance Index: -15.3400
  • Cell Name: corneal endothelial cell (CL0000132)
    Fold Change: -0.4890
    Cell Significance Index: -7.4400
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.4901
    Cell Significance Index: -9.6900
  • Cell Name: hippocampal interneuron (CL1001569)
    Fold Change: -0.5062
    Cell Significance Index: -6.5700
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.5251
    Cell Significance Index: -24.6800
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: -0.5302
    Cell Significance Index: -31.8300
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.5654
    Cell Significance Index: -12.3800
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.6064
    Cell Significance Index: -39.1200
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.6236
    Cell Significance Index: -13.5100
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.6258
    Cell Significance Index: -20.4900
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.6268
    Cell Significance Index: -32.6500
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.6381
    Cell Significance Index: -12.8100
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.6538
    Cell Significance Index: -51.7800
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.7032
    Cell Significance Index: -36.5300
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.7063
    Cell Significance Index: -18.9300
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.7064
    Cell Significance Index: -52.6500
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.7135
    Cell Significance Index: -50.4600
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.7336
    Cell Significance Index: -10.5100
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.7469
    Cell Significance Index: -39.2200
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: -0.7767
    Cell Significance Index: -9.9600
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.7955
    Cell Significance Index: -25.4800
  • Cell Name: midget ganglion cell of retina (CL4023188)
    Fold Change: -0.8237
    Cell Significance Index: -8.5800
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.8246
    Cell Significance Index: -9.8300

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **WD repeat domains**: The FRITZ_HUMAN protein contains WD repeat domains, which are characteristic of proteins involved in cell signaling and polarity regulation. 2. **Planar cell polarity effector**: WDPCP is involved in the establishment of planar polarity, a critical process in tissue morphogenesis and organ development. 3. **Regulation of cell migration**: WDPCP plays a role in regulating cell migration, which is essential for tissue development, repair, and homeostasis. 4. **Expression in various cell types**: WDPCP is expressed in a wide range of cell types, including hematopoietic cells, smooth muscle fibers, and epithelial cells. **Pathways and Functions:** WDPCP is involved in several developmental pathways, including: 1. **Establishment of planar polarity**: WDPCP regulates the establishment of planar polarity in various tissues, including the nervous system, kidney, and respiratory system. 2. **Regulation of cell migration**: WDPCP plays a role in regulating cell migration, which is essential for tissue development, repair, and homeostasis. 3. **Intraciliary transport**: WDPCP is involved in the regulation of intraciliary transport, which is critical for the proper functioning of cilia. 4. **Smoothened signaling pathway**: WDPCP interacts with the Smoothened signaling pathway, which is involved in the regulation of cell polarity and development. **Clinical Significance:** WDPCP dysregulation has been implicated in various diseases and disorders, including: 1. **Cilia-related disorders**: WDPCP mutations have been associated with cilia-related disorders, such as primary ciliary dyskinesia and polycystic kidney disease. 2. **Neurological disorders**: WDPCP dysregulation has been linked to neurological disorders, including autism and schizophrenia. 3. **Cancer**: WDPCP expression is altered in various types of cancer, including breast cancer and osteosarcoma. 4. **Immune system disorders**: WDPCP dysregulation has been implicated in immune system disorders, including autoimmune diseases and inflammatory bowel disease. In conclusion, WDPCP is a critical gene involved in the regulation of cell polarity, migration, and development in various tissues. Its dysregulation has been implicated in various diseases and disorders, highlighting the importance of further research into its function and clinical significance.

Genular Protein ID: 1227864380

Symbol: FRITZ_HUMAN

Name: WD repeat-containing and planar cell polarity effector protein fritz homolog

UniProtKB Accession Codes:

O95876 Q53RW4 Q7Z2Z3

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CTD 1 ChiTaRS 1 ComplexPortal 1 DNASU 1 DisGeNET 1 EMBL 8 EMDB 1 Ensembl 3 ExpressionAtlas 1 GO 31 Gene3D 1 GeneCards 1 GeneReviews 1 GeneTree 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MIM 5 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 2 OrthoDB 1 PANTHER 2 PDB 1 PDBsum 1 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 RNAct 1 RefSeq 2 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 17974005

Title: The full-ORF clone resource of the German cDNA consortium.

PubMed ID: 17974005

DOI: 10.1186/1471-2164-8-399

PubMed ID: 15815621

Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.

PubMed ID: 15815621

DOI: 10.1038/nature03466

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 35427153

Title: Structure of the ciliogenesis-associated CPLANE complex.

PubMed ID: 35427153

DOI: 10.1126/sciadv.abn0832

PubMed ID: 20671153

Title: Planar cell polarity acts through septins to control collective cell movement and ciliogenesis.

PubMed ID: 20671153

DOI: 10.1126/science.1191184

PubMed ID: 25427950

Title: Compound heterozygosity for a frame shift mutation and a likely pathogenic sequence variant in the planar cell polarity-ciliogenesis gene WDPCP in a girl with polysyndactyly, coarctation of the aorta, and tongue hamartomas.

PubMed ID: 25427950

DOI: 10.1002/ajmg.a.36852

PubMed ID: 27158779

Title: The ciliopathy-associated CPLANE proteins direct basal body recruitment of intraflagellar transport machinery.

PubMed ID: 27158779

DOI: 10.1038/ng.3558

Sequence Information:

  • Length: 746
  • Mass: 85084
  • Checksum: 585EFED0D93EB3D4
  • Sequence:
    • MRREFCWDAY SKAAGSRASS PLPRQDRDSF CHQMSFCLTE LHLWSLKNTL HIADRDIGIY 
QYYDKKDPPA TEHGNLEKKQ KLAESRDYPW TLKNRRPEKL RDSLKELEEL MQNSRCVLSK 
WKNKYVCQLL FGSGVLVSLS LSGPQLEKVV IDRSLVGKLI SDTISDALLT DSFIILSFLA 
QNKLCFIQFT KKMESSDVNK RLEKLSALDY KIFYYEIPGP INKTTERHLA INCVHDRVVC 
WWPLVNDDAW PWAPISSEKD RANLLLLGYA QGRLEVLSSV RTEWDPLDVR FGTKQPYQVF 
TVEHSVSVDK EPMADSCIYE CIRNKIQCVS VTRIPLKSKA ISCCRNVTED KLILGCEDSS 
LILYETHRRV TLLAQTELLP SLISCHPSGA ILLVGSNQGE LQIFDMALSP INIQLLAEDR 
LPRETLQFSK LFDASSSLVQ MQWIAPQVVS QKGEGSDIYD LLFLRFERGP LGVLLFKLGV 
FTRGQLGLID IIFQYIHCDE IYEAINILSS MNWDTLGHQC FISMSAIVNH LLRQKLTPER 
EAQLETSLGT FYAPTRPLLD STILEYRDQI SKYARRFFHH LLRYQRFEKA FLLAVDVGAR 
DLFMDIHYLA LDKGELALAE VARKRASDID AESITSGVEL LGPLDRGDML NEAFIGLSLA 
PQGEDSFPDN LPPSCPTHRH ILQQRILNGS SNRQIIDRRN ELEKDICSGF LMTNTCNAED 
GELREDGREQ EIRDGGSLKM IHFGLV

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.