Details for: HP1BP3
Gene ID: 50809
Gene Type: Protein-coding - A gene that serves as a template for producing a messenger RNA (mRNA) molecule, which is then translated into a functional protein.
Symbol: HP1BP3
Ensembl ID: ENSG00000127483
Description: heterochromatin protein 1 binding protein 3
Selected Context(s): Overall
Cell Significance Landscape
Associated with
Significant Cells
Cell Significance Index (CSI) scores for the chosen context(s)
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CSI 57.19rCSI 55.05%PRS 10.5
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CSI 39.31rCSI 30.29%PRS 9.2
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CSI 38.12rCSI 63.98%PRS 5.98
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CSI 37.39rCSI 43.18%PRS 9
-
CSI 34.49rCSI 31.14%PRS 8.99
-
CSI 31.56rCSI 36.13%PRS 20.96
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CSI 29.15rCSI 70.84%PRS 5.83
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CSI 27.75rCSI 37.09%PRS 19.44
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CSI 25.68rCSI 100%PRS 13.9
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CSI 25.2rCSI 38.49%PRS 10.2
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CSI 23.91rCSI 40.96%PRS 13.64
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CSI 23.22rCSI 63.8%PRS 16.88
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CSI 23.18rCSI 72.45%PRS 6.4
-
CSI 23.13rCSI 27.17%PRS 12.07
-
CSI 21.74rCSI 62.06%PRS 17.77
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CSI 21.25rCSI 32.5%PRS 16.53
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CSI 20.81rCSI 13.83%PRS 12.14
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CSI 19.42rCSI 46.68%PRS 15.39
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CSI 19.09rCSI 51.45%PRS 13.13
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CSI 18.19rCSI 29.25%PRS 6.67
-
CSI 18.01rCSI 64.79%PRS 5.5
-
CSI 17.3rCSI 55.5%PRS 15.01
-
CSI 17.13rCSI 23.34%PRS 9.08
-
CSI 16.73rCSI 48.43%PRS 11.5
-
CSI 16.63rCSI 62.84%PRS 6.14
-
CSI 16.26rCSI 71.37%PRS 19.03
-
CSI 15.85rCSI 22.03%PRS 10.51
-
CSI 15.37rCSI 29.89%PRS 10.37
-
CSI 14.88rCSI 12.33%PRS 9.61
-
CSI 14.53rCSI 45.44%PRS 6.89
-
CSI 14.16rCSI 11.87%PRS 12.17
-
CSI 13.95rCSI 72.01%PRS 20.17
-
CSI 13.13rCSI 77.31%PRS 6.29
-
CSI 12.91rCSI 16.06%PRS 10.77
-
CSI 12.26rCSI 18.95%PRS 9.53
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CSI 12.17rCSI 28.92%PRS 15.29
-
CSI 11.56rCSI 13.88%PRS 10.05
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CSI 11.21rCSI 9.84%PRS 11.43
-
CSI 10.56rCSI 77.59%PRS 5.01
-
CSI 10.42rCSI 51.34%PRS 13.82
-
CSI 10rCSI 53.95%PRS 19.23
-
CSI 9.8rCSI 7.75%PRS 7.01
-
CSI 9.73rCSI 9.38%PRS 6.77
-
CSI 9.2rCSI 21.43%PRS 22.65
-
CSI 8.92rCSI 15.75%PRS 5.97
-
CSI 8.68rCSI 13.81%PRS 8.8
-
CSI 8.51rCSI 6.88%PRS 10.05
-
CSI 8.42rCSI 12.32%PRS 10.76
-
CSI 8.34rCSI 8.5%PRS 14.52
-
CSI 8.32rCSI 32.4%PRS 16.74
-
CSI 8.27rCSI 41.11%PRS 11.58
-
CSI 7.56rCSI 16.71%PRS 7.29
-
CSI 7.51rCSI 19.31%PRS 15.31
-
CSI 7.45rCSI 13.54%PRS 8.39
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CSI 7.41rCSI 26.3%PRS 16.67
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CSI 7.39rCSI 6.22%PRS 16.58
-
CSI 7.02rCSI 8.39%PRS 5.9
-
CSI 6.79rCSI 12.16%PRS 9.54
-
CSI 6.66rCSI 50%PRS 18.9
-
CSI 6.57rCSI 26.14%PRS 17.86
-
CSI 6.42rCSI 9.16%PRS 11.48
-
CSI 6.41rCSI 17.06%PRS 8.28
-
CSI 6.29rCSI 7.89%PRS 12.99
-
CSI 6.2rCSI 40.66%PRS 26.47
-
CSI 6.17rCSI 8.9%PRS 14.18
-
CSI 6.09rCSI 17.97%PRS 12.65
-
CSI 5.51rCSI 8.46%PRS 14.52
-
CSI 5.31rCSI 28.72%PRS 34.41
-
CSI 5.2rCSI 7.73%PRS 12.54
-
CSI 5.19rCSI 18.44%PRS 31.97
-
CSI 5.14rCSI 4.26%PRS 10.18
-
CSI 4.97rCSI 17.01%PRS 9.55
-
CSI 4.87rCSI 12.83%PRS 19.97
-
CSI 4.76rCSI 4.1%PRS 16.63
-
CSI 4.67rCSI 24.53%PRS 18.68
-
CSI 4.66rCSI 25.38%PRS 25.54
-
CSI 4.63rCSI 3.5%PRS 14.11
-
CSI 4.53rCSI 3.51%PRS 9.7
-
CSI 4.39rCSI 25.54%PRS 15.28
-
CSI 4.24rCSI 5.47%PRS 6.32
-
CSI 4.23rCSI 11.86%PRS 15.8
-
CSI 4.07rCSI 3.52%PRS 11.32
-
CSI 3.97rCSI 25.45%PRS 16.01
-
CSI 3.96rCSI 2.96%PRS 16.53
-
CSI 3.93rCSI 33.97%PRS 19.73
-
CSI 3.87rCSI 27.29%PRS 31.71
-
CSI 3.86rCSI 92.37%PRS 4.53
-
CSI 3.83rCSI 70.07%PRS 28.87
-
CSI 3.81rCSI 91.93%PRS 5.39
-
CSI 3.79rCSI 88.4%PRS 17.82
-
CSI 3.65rCSI 5.82%PRS 8.75
-
CSI 3.62rCSI 11.86%PRS 29.56
-
CSI 3.59rCSI 2.5%PRS 11.91
-
CSI 3.55rCSI 6.76%PRS 16.31
-
CSI 3.46rCSI 22.95%PRS 10.92
-
CSI 3.45rCSI 9.71%PRS 14.59
-
CSI 3.35rCSI 7.33%PRS 13.67
-
CSI 3.3rCSI 4.5%PRS 11.24
-
CSI 3.28rCSI 48.56%PRS 26.47
-
CSI 3.22rCSI 4.13%PRS 9.9
-
CSI -6.8rCSI -12.0%PRS 13.4%
-
CSI -5.6rCSI -7.4%PRS 14.2%
-
CSI -4.1rCSI -44.3%PRS 41.2%
-
CSI -3.8rCSI -4.4%PRS 14.1%
-
CSI -3.7rCSI -8.4%PRS 10.7%
-
CSI -3.5rCSI -6.5%PRS 7.5%
-
CSI -1.9rCSI -4.3%PRS 6.3%
-
CSI -1.6rCSI -4.2%PRS 12.2%
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CSI -1.3rCSI -22.0%PRS 41.4%
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CSI -1.1rCSI -2.6%PRS 13.0%
-
CSI -1.1rCSI -1.4%PRS 14.5%
-
CSI -1.0rCSI -2.1%PRS 24.0%
-
CSI -0.9rCSI -1.3%PRS 14.0%
-
CSI -0.7rCSI -1.1%PRS 10.4%
-
CSI -0.6rCSI -0.8%PRS 11.7%
-
CSI -0.6rCSI -0.9%PRS 11.1%
-
CSI -0.5rCSI -1.2%PRS 11.5%
-
CSI -0.4rCSI -0.3%PRS 15.2%
-
CSI -0.4rCSI -0.4%PRS 8.7%
-
CSI -0.3rCSI -0.5%PRS 17.8%
-
CSI -0.2rCSI -0.2%PRS 7.5%
-
CSI -0.1rCSI -0.8%PRS 13.8%
-
CSI -0.1rCSI -0.2%PRS 15.6%
-
CSI -0.1rCSI -0.1%PRS 12.8%
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CSI -0.1rCSI -0.3%PRS 8.1%
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CSI 0.0rCSI -0.1%PRS 15.0%
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CSI 0.0rCSI 0.1%PRS 22.5%
-
CSI 0.1rCSI 0.4%PRS 2.7%
-
CSI 0.1rCSI 0.2%PRS 20.1%
-
CSI 0.1rCSI 0.1%PRS 13.2%
-
CSI 0.1rCSI 0.3%PRS 17.3%
-
CSI 0.1rCSI 1.0%PRS 30.8%
-
CSI 0.1rCSI 1.0%PRS 42.1%
-
CSI 0.1rCSI 2.4%PRS 40.8%
-
CSI 0.2rCSI 3.7%PRS 47.0%
-
CSI 0.2rCSI 1.0%PRS 39.0%
-
CSI 0.2rCSI 0.6%PRS 11.3%
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CSI 0.2rCSI 0.5%PRS 14.1%
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CSI 0.2rCSI 0.8%PRS 10.1%
-
CSI 0.2rCSI 1.7%PRS 32.7%
-
CSI 0.2rCSI 1.1%PRS 32.2%
-
CSI 0.2rCSI 0.4%PRS 10.8%
-
CSI 0.2rCSI 0.4%PRS 20.1%
-
CSI 0.2rCSI 1.5%PRS 20.0%
-
CSI 0.2rCSI 1.6%PRS 10.2%
-
CSI 0.2rCSI 5.3%PRS 35.7%
-
CSI 0.2rCSI 1.1%PRS 30.7%
-
CSI 0.2rCSI 1.3%PRS 19.7%
-
CSI 0.2rCSI 1.0%PRS 18.4%
-
CSI 0.2rCSI 4.6%PRS 58.4%
-
CSI 0.2rCSI 1.1%PRS 19.7%
-
CSI 0.3rCSI 1.0%PRS 15.5%
-
CSI 0.3rCSI 0.6%PRS 9.5%
-
CSI 0.3rCSI 2.7%PRS 19.7%
-
CSI 0.3rCSI 2.3%PRS 43.3%
-
CSI 0.3rCSI 2.0%PRS 9.4%
-
CSI 0.3rCSI 0.3%PRS 11.6%
-
CSI 0.3rCSI 0.3%PRS 17.5%
-
CSI 0.3rCSI 1.3%PRS 36.4%
-
CSI 0.3rCSI 1.0%PRS 5.0%
-
CSI 0.3rCSI 0.2%PRS 12.2%
-
CSI 0.3rCSI 0.4%PRS 12.0%
-
CSI 0.3rCSI 0.6%PRS 22.1%
-
CSI 0.3rCSI 0.6%PRS 28.1%
-
CSI 0.4rCSI 1.0%PRS 7.5%
-
CSI 0.4rCSI 0.4%PRS 18.1%
-
CSI 0.4rCSI 1.9%PRS 18.4%
-
CSI 0.4rCSI 4.0%PRS 27.6%
-
CSI 0.4rCSI 5.3%PRS 55.5%
-
CSI 0.4rCSI 2.3%PRS 30.2%
-
CSI 0.4rCSI 1.0%PRS 17.0%
-
CSI 0.4rCSI 2.1%PRS 31.2%
-
CSI 0.4rCSI 2.5%PRS 33.0%
-
CSI 0.4rCSI 0.6%PRS 9.5%
-
CSI 0.4rCSI 8.1%PRS 63.4%
-
CSI 0.4rCSI 0.5%PRS 24.8%
-
CSI 0.4rCSI 1.1%PRS 42.7%
-
CSI 0.4rCSI 1.0%PRS 10.3%
-
CSI 0.4rCSI 0.3%PRS 17.9%
-
CSI 0.4rCSI 1.2%PRS 9.8%
-
CSI 0.4rCSI 0.5%PRS 15.1%
-
CSI 0.4rCSI 0.9%PRS 21.2%
-
CSI 0.4rCSI 0.5%PRS 15.6%
-
CSI 0.4rCSI 0.6%PRS 15.0%
-
CSI 0.4rCSI 0.4%PRS 21.4%
-
CSI 0.4rCSI 12.8%PRS 23.8%
-
CSI 0.4rCSI 0.6%PRS 8.1%
-
CSI 0.4rCSI 0.9%PRS 10.9%
-
CSI 0.4rCSI 0.7%PRS 7.9%
-
CSI 0.5rCSI 2.4%PRS 12.9%
-
CSI 0.5rCSI 7.2%PRS 52.2%
-
CSI 0.5rCSI 0.5%PRS 19.1%
-
CSI 0.5rCSI 1.2%PRS 10.5%
-
CSI 0.5rCSI 1.2%PRS 28.6%
-
CSI 0.5rCSI 0.7%PRS 16.3%
-
CSI 0.5rCSI 0.7%PRS 10.2%
-
CSI 0.5rCSI 4.4%PRS 43.5%
-
CSI 0.5rCSI 2.8%PRS 11.3%
-
CSI 0.5rCSI 3.8%PRS 10.8%
-
CSI 0.5rCSI 0.5%PRS 10.8%
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Network Configuration
Explore relationships of the current gene. Select an Interaction Source: 'ONTOLOGY' for shared pathways (GO/Reactome) or 'STRING' for protein-protein interactions. Further refine by selecting context genes and comparing Cell Significance Index (CSI) scores between baseline and target cell types and their specific contexts.
Legend:
- Query Gene
-
Node Color (Target Cell CSI, relative to current network):
- Very High
- High
- Medium
- Low
- Very Low
- CSI N/A
- Node Size: Proportional to Target Cell CSI magnitude
- STRING PPI Edge
- Shared Pathway Edge (ONTOLOGY)
Other Information
This section provides additional information about the gene, including a description generated by an AI language model and details about associated proteins.
Genular Protein ID: 1922827339
Symbol: HP1B3_HUMAN
Name: Heterochromatin protein 1-binding protein 3
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 10931946
Title: Gene expression profiling in the human hypothalamus-pituitary-adrenal axis and full-length cDNA cloning.
PubMed ID: 10931946
PubMed ID: 14702039
Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.
PubMed ID: 14702039
DOI: 10.1038/ng1285
PubMed ID: 17974005
Title: The full-ORF clone resource of the German cDNA consortium.
PubMed ID: 17974005
PubMed ID: 16710414
Title: The DNA sequence and biological annotation of human chromosome 1.
PubMed ID: 16710414
DOI: 10.1038/nature04727
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 17081983
Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.
PubMed ID: 17081983
PubMed ID: 17525332
Title: ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage.
PubMed ID: 17525332
PubMed ID: 19367720
Title: Phosphorylation analysis of primary human T lymphocytes using sequential IMAC and titanium oxide enrichment.
PubMed ID: 19367720
DOI: 10.1021/pr800500r
PubMed ID: 18669648
Title: A quantitative atlas of mitotic phosphorylation.
PubMed ID: 18669648
PubMed ID: 19690332
Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.
PubMed ID: 19690332
PubMed ID: 20042602
Title: The middle region of an HP1-binding protein, HP1-BP74, associates with linker DNA at the entry/exit site of nucleosomal DNA.
PubMed ID: 20042602
PubMed ID: 20068231
Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.
PubMed ID: 20068231
PubMed ID: 21269460
Title: Initial characterization of the human central proteome.
PubMed ID: 21269460
PubMed ID: 21406692
Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.
PubMed ID: 21406692
PubMed ID: 23186163
Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.
PubMed ID: 23186163
DOI: 10.1021/pr300630k
PubMed ID: 24275569
Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.
PubMed ID: 24275569
PubMed ID: 24830416
Title: Profiling of the chromatin-associated proteome identifies HP1BP3 as a novel regulator of cell cycle progression.
PubMed ID: 24830416
PubMed ID: 25100860
Title: Quantitative profiling of chromatome dynamics reveals a novel role for HP1BP3 in hypoxia-induced oncogenesis.
PubMed ID: 25100860
PubMed ID: 28112733
Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.
PubMed ID: 28112733
DOI: 10.1038/nsmb.3366
Sequence Information:
- Length: 553
- Mass: 61207
- Checksum: D18B28EE0156F09B
- Sequence:
MATDTSQGEL VHPKALPLIV GAQLIHADKL GEKVEDSTMP IRRTVNSTRE TPPKSKLAEG EEEKPEPDIS SEESVSTVEE QENETPPATS SEAEQPKGEP ENEEKEENKS SEETKKDEKD QSKEKEKKVK KTIPSWATLS ASQLARAQKQ TPMASSPRPK MDAILTEAIK ACFQKSGASV VAIRKYIIHK YPSLELERRG YLLKQALKRE LNRGVIKQVK GKGASGSFVV VQKSRKTPQK SRNRKNRSSA VDPEPQVKLE DVLPLAFTRL CEPKEASYSL IRKYVSQYYP KLRVDIRPQL LKNALQRAVE RGQLEQITGK GASGTFQLKK SGEKPLLGGS LMEYAILSAI AAMNEPKTCS TTALKKYVLE NHPGTNSNYQ MHLLKKTLQK CEKNGWMEQI SGKGFSGTFQ LCFPYYPSPG VLFPKKEPDD SRDEDEDEDE SSEEDSEDEE PPPKRRLQKK TPAKSPGKAA SVKQRGSKPA PKVSAAQRGK ARPLPKKAPP KAKTPAKKTR PSSTVIKKPS GGSSKKPATS ARKEVKLPGK GKSTMKKSFR VKK