Details for: HP1BP3

Gene ID: 50809

Symbol: HP1BP3

Ensembl ID: ENSG00000127483

Description: heterochromatin protein 1 binding protein 3

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 581.9529
    Cell Significance Index: -90.5200
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 385.8173
    Cell Significance Index: -97.8600
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 245.9293
    Cell Significance Index: -101.3100
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 235.1508
    Cell Significance Index: -111.0200
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 227.2945
    Cell Significance Index: -92.3400
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 205.3908
    Cell Significance Index: -105.6500
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 165.5087
    Cell Significance Index: -111.0600
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 97.8064
    Cell Significance Index: -93.3800
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 87.1645
    Cell Significance Index: -107.4700
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 37.7735
    Cell Significance Index: -101.1900
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 29.1588
    Cell Significance Index: -89.5600
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 27.8101
    Cell Significance Index: -109.7400
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 24.2165
    Cell Significance Index: -53.0000
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 2.6963
    Cell Significance Index: 151.3000
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 2.2863
    Cell Significance Index: 248.6900
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 2.2497
    Cell Significance Index: 60.0700
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 2.2225
    Cell Significance Index: 445.8400
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 2.0990
    Cell Significance Index: 288.2600
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: 2.0008
    Cell Significance Index: 39.0500
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 1.8676
    Cell Significance Index: 370.6300
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 1.8353
    Cell Significance Index: 225.6700
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 1.7961
    Cell Significance Index: 323.7800
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 1.7672
    Cell Significance Index: 80.1000
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 1.6007
    Cell Significance Index: 574.1500
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 1.5980
    Cell Significance Index: 44.6600
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 1.5796
    Cell Significance Index: 82.2800
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 1.4831
    Cell Significance Index: 42.7300
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 1.3264
    Cell Significance Index: 81.5300
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 1.3189
    Cell Significance Index: 35.9000
  • Cell Name: cone retinal bipolar cell (CL0000752)
    Fold Change: 1.2870
    Cell Significance Index: 9.9200
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 1.2488
    Cell Significance Index: 160.0900
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 1.0809
    Cell Significance Index: 590.3200
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 1.0468
    Cell Significance Index: 462.8300
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.0360
    Cell Significance Index: 79.5000
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.9499
    Cell Significance Index: 44.2900
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.9495
    Cell Significance Index: 111.9700
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.8749
    Cell Significance Index: 56.4500
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.8114
    Cell Significance Index: 38.1400
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.7839
    Cell Significance Index: 127.4900
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.7773
    Cell Significance Index: 40.8100
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.6416
    Cell Significance Index: 579.3600
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.3783
    Cell Significance Index: 261.6800
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 0.3712
    Cell Significance Index: 10.6400
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 0.3416
    Cell Significance Index: 11.8700
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.3290
    Cell Significance Index: 62.6200
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.2553
    Cell Significance Index: 8.9700
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.2053
    Cell Significance Index: 35.0500
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 0.1421
    Cell Significance Index: 6.2900
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.1041
    Cell Significance Index: 66.1000
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0937
    Cell Significance Index: 176.3400
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0580
    Cell Significance Index: 89.3200
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0248
    Cell Significance Index: 45.7700
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.0227
    Cell Significance Index: 16.6200
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.0187
    Cell Significance Index: 1.3200
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0150
    Cell Significance Index: 20.4500
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.0111
    Cell Significance Index: 5.0300
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.0003
    Cell Significance Index: -0.0100
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.0151
    Cell Significance Index: -0.9500
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0293
    Cell Significance Index: -0.4900
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.0475
    Cell Significance Index: -2.4700
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0625
    Cell Significance Index: -46.3000
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.0636
    Cell Significance Index: -1.4700
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0691
    Cell Significance Index: -43.1300
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0710
    Cell Significance Index: -53.7100
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.1207
    Cell Significance Index: -15.5900
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.1504
    Cell Significance Index: -84.8200
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.1586
    Cell Significance Index: -4.1700
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.1771
    Cell Significance Index: -18.0900
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.2031
    Cell Significance Index: -5.2200
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.2097
    Cell Significance Index: -14.1000
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.2753
    Cell Significance Index: -57.9800
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: -0.2882
    Cell Significance Index: -28.5100
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.2910
    Cell Significance Index: -6.9800
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.3332
    Cell Significance Index: -95.8800
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.3548
    Cell Significance Index: -51.5800
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: -0.4592
    Cell Significance Index: -31.7600
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.4596
    Cell Significance Index: -34.2500
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.4905
    Cell Significance Index: -56.0000
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.5345
    Cell Significance Index: -9.1600
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.5388
    Cell Significance Index: -62.7900
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.5926
    Cell Significance Index: -12.4100
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.6754
    Cell Significance Index: -77.3800
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.8682
    Cell Significance Index: -11.8500
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.9437
    Cell Significance Index: -98.2600
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.9619
    Cell Significance Index: -76.1900
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -1.1304
    Cell Significance Index: -33.2000
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -1.2979
    Cell Significance Index: -41.5700
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -1.4150
    Cell Significance Index: -35.3700
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -1.4235
    Cell Significance Index: -30.8400
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: -1.5145
    Cell Significance Index: -12.3500
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -1.5381
    Cell Significance Index: -28.4300
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -1.5672
    Cell Significance Index: -96.0900
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: -1.5854
    Cell Significance Index: -95.1800
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -1.8073
    Cell Significance Index: -46.1700
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -1.8418
    Cell Significance Index: -52.5600
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: -1.9189
    Cell Significance Index: -46.8200
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -1.9793
    Cell Significance Index: -53.0400
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: -2.1704
    Cell Significance Index: -26.9200
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -2.1885
    Cell Significance Index: -71.6500
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -2.2270
    Cell Significance Index: -59.5700

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** HP1BP3 exhibits several key characteristics that define its function: 1. **Cellular specificity**: HP1BP3 is expressed in a range of cell types, including hematopoietic oligopotent progenitor cells, embryonic stem cells, and smooth muscle fibers. 2. **Heterochromatin organization**: HP1BP3 is involved in the assembly and binding of nucleosomes, which are essential for the formation and maintenance of heterochromatin. 3. **Transcriptional regulation**: HP1BP3 has been implicated in the regulation of DNA-templated transcription, which is the process by which RNA polymerase reads the template DNA and synthesizes a complementary RNA molecule. 4. **Cell proliferation and differentiation**: HP1BP3 has been shown to regulate cell proliferation and differentiation, particularly in hematopoietic cells. **Pathways and Functions** HP1BP3 is involved in several key pathways, including: 1. **Cellular response to hypoxia**: HP1BP3 has been shown to regulate the expression of genes involved in the cellular response to hypoxia, which is a critical adaptation mechanism in low-oxygen environments. 2. **Chromosome organization**: HP1BP3 plays a role in the organization of chromosomes, particularly in the formation and maintenance of heterochromatin. 3. **DNA binding**: HP1BP3 has been shown to bind to DNA and regulate gene expression, particularly in the context of heterochromatin formation. 4. **Nucleosome assembly and binding**: HP1BP3 is involved in the assembly and binding of nucleosomes, which are essential for the formation and maintenance of chromatin structure. **Clinical Significance** HP1BP3 has several clinical implications, including: 1. **Hematological disorders**: HP1BP3 has been implicated in the regulation of hematopoietic cell proliferation and differentiation, which is critical in the development of hematological disorders such as leukemia and lymphoma. 2. **Cancer**: HP1BP3 has been shown to regulate cell proliferation and differentiation in various types of cancer, including breast cancer and colon cancer. 3. **Neurological disorders**: HP1BP3 has been implicated in the regulation of neuronal function and development, which is critical in the development of neurological disorders such as Alzheimer's disease and Parkinson's disease. 4. **Immunological disorders**: HP1BP3 has been shown to regulate immune cell function and development, which is critical in the development of immunological disorders such as autoimmune diseases and immunodeficiency diseases. In conclusion, HP1BP3 is a critical gene that plays a key role in the regulation of cellular processes, including heterochromatin organization, transcriptional regulation, and cell proliferation and differentiation. Further research is needed to fully elucidate the function and clinical significance of HP1BP3, but its involvement in various diseases and disorders highlights its importance in human health and disease.

Genular Protein ID: 1922827339

Symbol: HP1B3_HUMAN

Name: Heterochromatin protein 1-binding protein 3

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 10931946

Title: Gene expression profiling in the human hypothalamus-pituitary-adrenal axis and full-length cDNA cloning.

PubMed ID: 10931946

DOI: 10.1073/pnas.160270997

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 17974005

Title: The full-ORF clone resource of the German cDNA consortium.

PubMed ID: 17974005

DOI: 10.1186/1471-2164-8-399

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 17081983

Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.

PubMed ID: 17081983

DOI: 10.1016/j.cell.2006.09.026

PubMed ID: 17525332

Title: ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage.

PubMed ID: 17525332

DOI: 10.1126/science.1140321

PubMed ID: 19367720

Title: Phosphorylation analysis of primary human T lymphocytes using sequential IMAC and titanium oxide enrichment.

PubMed ID: 19367720

DOI: 10.1021/pr800500r

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 20042602

Title: The middle region of an HP1-binding protein, HP1-BP74, associates with linker DNA at the entry/exit site of nucleosomal DNA.

PubMed ID: 20042602

DOI: 10.1074/jbc.m109.092833

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 24830416

Title: Profiling of the chromatin-associated proteome identifies HP1BP3 as a novel regulator of cell cycle progression.

PubMed ID: 24830416

DOI: 10.1074/mcp.m113.034975

PubMed ID: 25100860

Title: Quantitative profiling of chromatome dynamics reveals a novel role for HP1BP3 in hypoxia-induced oncogenesis.

PubMed ID: 25100860

DOI: 10.1074/mcp.m114.038232

PubMed ID: 28112733

Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.

PubMed ID: 28112733

DOI: 10.1038/nsmb.3366

Sequence Information:

  • Length: 553
  • Mass: 61207
  • Checksum: D18B28EE0156F09B
  • Sequence:
  • MATDTSQGEL VHPKALPLIV GAQLIHADKL GEKVEDSTMP IRRTVNSTRE TPPKSKLAEG 
    EEEKPEPDIS SEESVSTVEE QENETPPATS SEAEQPKGEP ENEEKEENKS SEETKKDEKD 
    QSKEKEKKVK KTIPSWATLS ASQLARAQKQ TPMASSPRPK MDAILTEAIK ACFQKSGASV 
    VAIRKYIIHK YPSLELERRG YLLKQALKRE LNRGVIKQVK GKGASGSFVV VQKSRKTPQK 
    SRNRKNRSSA VDPEPQVKLE DVLPLAFTRL CEPKEASYSL IRKYVSQYYP KLRVDIRPQL 
    LKNALQRAVE RGQLEQITGK GASGTFQLKK SGEKPLLGGS LMEYAILSAI AAMNEPKTCS 
    TTALKKYVLE NHPGTNSNYQ MHLLKKTLQK CEKNGWMEQI SGKGFSGTFQ LCFPYYPSPG 
    VLFPKKEPDD SRDEDEDEDE SSEEDSEDEE PPPKRRLQKK TPAKSPGKAA SVKQRGSKPA 
    PKVSAAQRGK ARPLPKKAPP KAKTPAKKTR PSSTVIKKPS GGSSKKPATS ARKEVKLPGK 
    GKSTMKKSFR VKK

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.