Details for: SPOCK3

Gene ID: 50859

Symbol: SPOCK3

Ensembl ID: ENSG00000196104

Description: SPARC (osteonectin), cwcv and kazal like domains proteoglycan 3

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 216.4259
    Cell Significance Index: -54.9000
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 50.2020
    Cell Significance Index: -47.9300
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 45.1192
    Cell Significance Index: -55.6300
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 10.1567
    Cell Significance Index: 222.4000
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 8.0092
    Cell Significance Index: 99.3400
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 6.9131
    Cell Significance Index: -15.1300
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 6.3058
    Cell Significance Index: 278.9200
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 5.9844
    Cell Significance Index: 226.6200
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 5.8631
    Cell Significance Index: 2103.0100
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 5.1929
    Cell Significance Index: 349.1800
  • Cell Name: hippocampal interneuron (CL1001569)
    Fold Change: 4.0456
    Cell Significance Index: 52.4700
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 3.0924
    Cell Significance Index: 2138.8100
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 2.4673
    Cell Significance Index: 151.6500
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: 1.3374
    Cell Significance Index: 32.0800
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.6283
    Cell Significance Index: 126.0300
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.5380
    Cell Significance Index: 1013.0200
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.5291
    Cell Significance Index: 32.4400
  • Cell Name: OFF midget ganglion cell (CL4033047)
    Fold Change: 0.4290
    Cell Significance Index: 5.3500
  • Cell Name: cerebral cortex neuron (CL0010012)
    Fold Change: 0.3342
    Cell Significance Index: 3.1800
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.1712
    Cell Significance Index: 8.9200
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.1256
    Cell Significance Index: 22.6500
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 0.1032
    Cell Significance Index: 2.0400
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.0998
    Cell Significance Index: 90.0700
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.0991
    Cell Significance Index: 18.8600
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 0.0678
    Cell Significance Index: 1.4400
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 0.0122
    Cell Significance Index: 1.7700
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0117
    Cell Significance Index: -8.6500
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0231
    Cell Significance Index: -42.6400
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: -0.0233
    Cell Significance Index: -0.2500
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0235
    Cell Significance Index: -14.6800
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0312
    Cell Significance Index: -48.0400
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0462
    Cell Significance Index: -62.7900
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0469
    Cell Significance Index: -29.7700
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0532
    Cell Significance Index: -24.1500
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.0744
    Cell Significance Index: -1.0700
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0815
    Cell Significance Index: -45.9400
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0974
    Cell Significance Index: -53.2000
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.1219
    Cell Significance Index: -6.3300
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.1672
    Cell Significance Index: -48.1200
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.1702
    Cell Significance Index: -5.9800
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.1828
    Cell Significance Index: -3.6700
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.1935
    Cell Significance Index: -33.0400
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.2100
    Cell Significance Index: -26.9200
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: -0.2108
    Cell Significance Index: -34.2900
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.2441
    Cell Significance Index: -51.4200
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.2532
    Cell Significance Index: -50.2400
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.2754
    Cell Significance Index: -33.8700
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.3105
    Cell Significance Index: -16.3000
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.3116
    Cell Significance Index: -14.1300
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: -0.3466
    Cell Significance Index: -34.2900
  • Cell Name: ON midget ganglion cell (CL4033046)
    Fold Change: -0.3518
    Cell Significance Index: -4.4400
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: -0.4053
    Cell Significance Index: -5.1200
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.4063
    Cell Significance Index: -55.7900
  • Cell Name: neural cell (CL0002319)
    Fold Change: -0.4406
    Cell Significance Index: -5.1400
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: -0.4561
    Cell Significance Index: -49.6100
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.4838
    Cell Significance Index: -56.3800
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.4866
    Cell Significance Index: -50.6700
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: -0.5151
    Cell Significance Index: -6.1600
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.5202
    Cell Significance Index: -59.3800
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.5245
    Cell Significance Index: -60.0900
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.5440
    Cell Significance Index: -55.5700
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.5968
    Cell Significance Index: -25.9500
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.6324
    Cell Significance Index: -48.5300
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.6664
    Cell Significance Index: -37.4000
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: -0.6998
    Cell Significance Index: -48.4000
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.7208
    Cell Significance Index: -53.7200
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.7830
    Cell Significance Index: -22.5600
  • Cell Name: L6 intratelencephalic projecting glutamatergic neuron of the primary motor cortex (CL4023050)
    Fold Change: -0.8205
    Cell Significance Index: -10.9500
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.8944
    Cell Significance Index: -57.7000
  • Cell Name: neuron (CL0000540)
    Fold Change: -0.9028
    Cell Significance Index: -8.5600
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: -0.9258
    Cell Significance Index: -55.5800
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.9369
    Cell Significance Index: -23.4200
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.9629
    Cell Significance Index: -31.5300
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.9737
    Cell Significance Index: -61.3700
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.9872
    Cell Significance Index: -27.5900
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -1.0587
    Cell Significance Index: -36.7900
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -1.0723
    Cell Significance Index: -22.3800
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -1.1034
    Cell Significance Index: -23.8400
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -1.1263
    Cell Significance Index: -52.9400
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -1.2106
    Cell Significance Index: -42.4100
  • Cell Name: chandelier cell (CL4023083)
    Fold Change: -1.2763
    Cell Significance Index: -10.3100
  • Cell Name: retinal bipolar neuron (CL0000748)
    Fold Change: -1.3142
    Cell Significance Index: -15.9300
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -1.3159
    Cell Significance Index: -22.5500
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -1.3244
    Cell Significance Index: -42.1800
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: -1.3454
    Cell Significance Index: -26.4800
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -1.3731
    Cell Significance Index: -33.2600
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -1.3894
    Cell Significance Index: -64.7800
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -1.4521
    Cell Significance Index: -15.8200
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -1.4530
    Cell Significance Index: -53.3400
  • Cell Name: cytotoxic T cell (CL0000910)
    Fold Change: -1.4665
    Cell Significance Index: -21.3800
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -1.5028
    Cell Significance Index: -44.2700
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -1.5042
    Cell Significance Index: -42.9300
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -1.5112
    Cell Significance Index: -48.4000
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -1.5733
    Cell Significance Index: -33.6300
  • Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
    Fold Change: -1.6159
    Cell Significance Index: -32.2200
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -1.6727
    Cell Significance Index: -41.7300
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: -1.6919
    Cell Significance Index: -14.3800
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -1.8032
    Cell Significance Index: -39.0700
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -1.8674
    Cell Significance Index: -53.5300
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: -1.9024
    Cell Significance Index: -38.7100

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** SPOCK3 is a proteoglycan composed of a core protein with multiple domains, including SPARC, cwcv, and kazal-like domains. These domains confer its ability to bind to various ECM components, such as glycosaminoglycans (GAGs), collagen, and metalloproteases. SPOCK3's structure and function are characterized by its capacity to regulate ECM degradation, modulate cell adhesion, and inhibit metalloendopeptidase activity. Its expression is dynamic, varying across different cell types and developmental stages. **Pathways and Functions:** SPOCK3's role in ECM homeostasis is mediated through several key pathways: 1. **Activation of Matrix Metalloproteinases (MMPs):** SPOCK3 inhibits the activity of MMPs, enzymes responsible for ECM degradation. By regulating MMP activity, SPOCK3 helps maintain ECM integrity and prevent excessive degradation. 2. **Calcium Ion Binding:** SPOCK3 binds to calcium ions, modulating its availability and influencing ECM structure and function. 3. **Degradation of the Extracellular Matrix:** SPOCK3 regulates ECM degradation by interacting with ECM components and modulating the activity of ECM-degrading enzymes. 4. **Extracellular Matrix Organization:** SPOCK3 helps maintain ECM organization by interacting with ECM components and regulating their assembly and disassembly. 5. **Glycosaminoglycan Binding:** SPOCK3 binds to GAGs, influencing ECM structure and function. **Clinical Significance:** Dysregulation of SPOCK3 has been implicated in various diseases, including: 1. **Cancer:** Altered SPOCK3 expression has been observed in various types of cancer, where it may contribute to tumor progression and metastasis. 2. **Neurological Disorders:** SPOCK3 has been implicated in neurological disorders, such as Alzheimer's disease, Parkinson's disease, and Huntington's disease, where it may contribute to disease pathogenesis. 3. **Cardiovascular Diseases:** SPOCK3 has been linked to cardiovascular diseases, including atherosclerosis and cardiac fibrosis, where it may play a role in ECM remodeling and disease progression. 4. **Musculoskeletal Disorders:** SPOCK3 has been implicated in musculoskeletal disorders, such as osteoarthritis and rheumatoid arthritis, where it may contribute to disease pathogenesis. In conclusion, SPOCK3 plays a crucial role in maintaining ECM homeostasis, and its dysregulation has been implicated in various diseases. Further research is necessary to elucidate the mechanisms underlying SPOCK3's function and its role in disease pathogenesis.

Genular Protein ID: 830762959

Symbol: TICN3_HUMAN

Name: Testican-3

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 11751414

Title: Suppression of membrane-type 1 matrix metalloproteinase (MMP)-mediated MMP-2 activation and tumor invasion by testican 3 and its splicing variant gene product, N-Tes.

PubMed ID: 11751414

PubMed ID: 12975309

Title: The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment.

PubMed ID: 12975309

DOI: 10.1101/gr.1293003

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15815621

Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.

PubMed ID: 15815621

DOI: 10.1038/nature03466

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 436
  • Mass: 49429
  • Checksum: AAEDD1998C656FC0
  • Sequence:
  • MLKVSAVLCV CAAAWCSQSL AAAAAVAAAG GRSDGGNFLD DKQWLTTISQ YDKEVGQWNK 
    FRDEVEDDYF RTWSPGKPFD QALDPAKDPC LKMKCSRHKV CIAQDSQTAV CISHRRLTHR 
    MKEAGVDHRQ WRGPILSTCK QCPVVYPSPV CGSDGHTYSF QCKLEYQACV LGKQISVKCE 
    GHCPCPSDKP TSTSRNVKRA CSDLEFREVA NRLRDWFKAL HESGSQNKKT KTLLRPERSR 
    FDTSILPICK DSLGWMFNRL DTNYDLLLDQ SELRSIYLDK NEQCTKAFFN SCDTYKDSLI 
    SNNEWCYCFQ RQQDPPCQTE LSNIQKRQGV KKLLGQYIPL CDEDGYYKPT QCHGSVGQCW 
    CVDRYGNEVM GSRINGVADC AIDFEISGDF ASGDFHEWTD DEDDEDDIMN DEDEIEDDDE 
    DEGDDDDGGD DHDVYI

Genular Protein ID: 454935074

Symbol: A0A0A0MTJ2_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 11181995

Title: The sequence of the human genome.

PubMed ID: 11181995

DOI: 10.1126/science.1058040

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

PubMed ID: 15815621

Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.

PubMed ID: 15815621

DOI: 10.1038/nature03466

Sequence Information:

  • Length: 344
  • Mass: 39401
  • Checksum: 7D2CD3AEC59E1082
  • Sequence:
  • MKCSRHKVCI AQDSQTAVCI SHRRLTHRMK EAGVDHRQWR GPILSTCKQC PVVYPSPVCG 
    SDGHTYSFQC KLEYQACVLG KQISVKCEGH CPCPSDKPTS TSRNVKRACS DLEFREVANR 
    LRDWFKALHE SGSQNKKTKT LLRPERSRFD TSILPICKDS LGWMFNRLDT NYDLLLDQSE 
    LRSIYLDKNE QCTKAFFNSC DTYKDSLISN NEWCYCFQRQ QDPPCQTELS NIQKRQGVKK 
    LLGQYIPLCD EDGYYKPTQC HGSVGQCWCV DRYGNEVMGS RINGVADCAI DFEISGDFAS 
    GDFHEWTDDE DDEDDIMNDE DEIEDDDEDE GDDDDGGDDH DVYI

Genular Protein ID: 1059616663

Symbol: B4DI52_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Sequence Information:

  • Length: 344
  • Mass: 39371
  • Checksum: 24ECD3AEC333A659
  • Sequence:
  • MKCSRHKVCI AQDSQTAVCI SHRRLTHRMK EAGVDHRQWR GPILSTCKQC PVVYPSPVCG 
    SDGHTYSFQC KLEYQACVLG KQISVKCEGH CPCPSDKPTG TSRNVKRACS DLEFREVANR 
    LRDWFKALHE SGSQNKKTKT LLRPERSRFD TSILPICKDS LGWMFNRLDT NYDLLLDQSE 
    LRSIYLDKNE QCTKAFFNSC DTYKDSLISN NEWCYCFQRQ QDPPCQTELS NIQKRQGVKK 
    LLGQYIPLCD EDGYYKPTQC HGSVGQCWCV DRYGNEVMGS RINGVADCAI DFEISGDFAS 
    GDFHEWTDDE DDEDDIMNDE DEIEDDDEDE GDDDDGGDDH DVYI

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.