Details for: RASGRF2

Gene ID: 5924

Symbol: RASGRF2

Ensembl ID: ENSG00000113319

Description: Ras protein specific guanine nucleotide releasing factor 2

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 225.3364
    Cell Significance Index: -35.0500
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 138.9549
    Cell Significance Index: -35.2500
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 60.6759
    Cell Significance Index: -24.6500
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 28.4155
    Cell Significance Index: -35.0400
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 12.3069
    Cell Significance Index: -37.8000
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 12.0424
    Cell Significance Index: -32.2600
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 8.9267
    Cell Significance Index: -35.2300
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 8.5657
    Cell Significance Index: 1245.1200
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 7.8315
    Cell Significance Index: -17.1400
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 6.7123
    Cell Significance Index: 96.5400
  • Cell Name: photoreceptor cell (CL0000210)
    Fold Change: 5.6903
    Cell Significance Index: 79.9200
  • Cell Name: chandelier cell (CL4023083)
    Fold Change: 3.4721
    Cell Significance Index: 28.0400
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 3.3574
    Cell Significance Index: 225.7600
  • Cell Name: hippocampal interneuron (CL1001569)
    Fold Change: 2.7455
    Cell Significance Index: 35.6100
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 2.0788
    Cell Significance Index: 417.0100
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 1.7874
    Cell Significance Index: 81.0200
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 1.5870
    Cell Significance Index: 60.1000
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 1.5741
    Cell Significance Index: 96.7500
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 1.5407
    Cell Significance Index: 305.7500
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: 1.5296
    Cell Significance Index: 43.6500
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 1.4497
    Cell Significance Index: 2729.6700
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 1.3537
    Cell Significance Index: 257.6200
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 1.1554
    Cell Significance Index: 72.8200
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 0.8573
    Cell Significance Index: 37.9200
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.8368
    Cell Significance Index: 82.7800
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.7979
    Cell Significance Index: 551.8800
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.7878
    Cell Significance Index: 711.3300
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 0.7114
    Cell Significance Index: 8.4800
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: 0.6809
    Cell Significance Index: 16.3300
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.6664
    Cell Significance Index: 239.0200
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: 0.6293
    Cell Significance Index: 3.9100
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.6268
    Cell Significance Index: 964.9700
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.6206
    Cell Significance Index: 394.1600
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.4154
    Cell Significance Index: 67.5600
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.3721
    Cell Significance Index: 686.3300
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.3447
    Cell Significance Index: 468.7300
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.2880
    Cell Significance Index: 16.1600
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.2411
    Cell Significance Index: 26.2200
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: 0.1374
    Cell Significance Index: 0.8300
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.1201
    Cell Significance Index: 15.4000
  • Cell Name: L6 intratelencephalic projecting glutamatergic neuron of the primary motor cortex (CL4023050)
    Fold Change: 0.0885
    Cell Significance Index: 1.1800
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.0649
    Cell Significance Index: 4.4900
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 0.0642
    Cell Significance Index: 1.2700
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.0507
    Cell Significance Index: 1.4600
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.0394
    Cell Significance Index: 2.0500
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.0208
    Cell Significance Index: 0.5200
  • Cell Name: adipocyte of breast (CL0002617)
    Fold Change: 0.0000
    Cell Significance Index: 0.0000
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0028
    Cell Significance Index: -0.1000
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0239
    Cell Significance Index: -10.8700
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0369
    Cell Significance Index: -27.0600
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0477
    Cell Significance Index: -26.0700
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0478
    Cell Significance Index: -35.4100
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0482
    Cell Significance Index: -36.4700
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: -0.0492
    Cell Significance Index: -0.5100
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.0580
    Cell Significance Index: -1.2300
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0599
    Cell Significance Index: -37.4000
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0607
    Cell Significance Index: -34.2600
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0669
    Cell Significance Index: -12.0700
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.0709
    Cell Significance Index: -1.0200
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: -0.0855
    Cell Significance Index: -37.8100
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0901
    Cell Significance Index: -25.9200
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: -0.1119
    Cell Significance Index: -6.7200
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.1149
    Cell Significance Index: -2.4900
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.1341
    Cell Significance Index: -13.7000
  • Cell Name: cerebral cortex neuron (CL0010012)
    Fold Change: -0.1377
    Cell Significance Index: -1.3100
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -0.1460
    Cell Significance Index: -3.1200
  • Cell Name: subcutaneous adipocyte (CL0002521)
    Fold Change: -0.1482
    Cell Significance Index: -0.6500
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1619
    Cell Significance Index: -16.8600
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.1655
    Cell Significance Index: -20.3500
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.1726
    Cell Significance Index: -3.7300
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1767
    Cell Significance Index: -37.2100
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.1807
    Cell Significance Index: -24.8100
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.2030
    Cell Significance Index: -34.6700
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.2464
    Cell Significance Index: -31.8300
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.2563
    Cell Significance Index: -5.3500
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.2655
    Cell Significance Index: -20.3800
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.2677
    Cell Significance Index: -5.3800
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.2794
    Cell Significance Index: -32.9600
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.2965
    Cell Significance Index: -12.8900
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.3034
    Cell Significance Index: -35.3600
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.3247
    Cell Significance Index: -37.2000
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.3381
    Cell Significance Index: -11.0700
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.3527
    Cell Significance Index: -27.9300
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.3630
    Cell Significance Index: -5.4700
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.3695
    Cell Significance Index: -11.8400
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.3743
    Cell Significance Index: -11.9200
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.4273
    Cell Significance Index: -9.1000
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.4283
    Cell Significance Index: -31.9200
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.4686
    Cell Significance Index: -8.0300
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.4755
    Cell Significance Index: -5.1800
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.4831
    Cell Significance Index: -31.1700
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.5001
    Cell Significance Index: -17.5200
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: -0.5036
    Cell Significance Index: -5.4000
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.5329
    Cell Significance Index: -32.6700
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.5421
    Cell Significance Index: -28.1600
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.5626
    Cell Significance Index: -29.5400
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.5627
    Cell Significance Index: -39.8000
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.5825
    Cell Significance Index: -16.2800
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.5989
    Cell Significance Index: -28.1500
  • Cell Name: tuft cell of small intestine (CL0009080)
    Fold Change: -0.6057
    Cell Significance Index: -6.1100

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** RASGRF2 is a guanine nucleotide-releasing factor (GNRF) that specifically regulates the activity of Ras proteins, which are small GTPases involved in various signaling pathways. The gene encodes a protein that interacts with Ras proteins to facilitate their activation, thereby regulating their GTPase activity. RASGRF2 is also involved in the regulation of small GTPases, such as Rac1, RhoA, and Cdc42, which are involved in various cellular processes, including cell proliferation, differentiation, and survival. **Pathways and Functions** RASGRF2 is involved in various signaling pathways, including: 1. **Activation of NMDA receptors and postsynaptic events**: RASGRF2 regulates the activity of NMDA receptors, which are critical for neurotransmitter release and synaptic plasticity. 2. **Calmodulin binding**: RASGRF2 interacts with calmodulin, a calcium-binding protein that regulates various cellular processes. 3. **Cdc42 GTPase cycle**: RASGRF2 regulates the activity of Cdc42, a small GTPase involved in cell migration, adhesion, and cytoskeleton organization. 4. **Cell death signaling via NRAGE, NRIF, and NADE**: RASGRF2 regulates the activity of NRAGE, NRIF, and NADE, which are involved in cell death signaling pathways. 5. **Creb1 phosphorylation through NMDA receptor-mediated activation of Ras signaling**: RASGRF2 regulates the activity of Creb1, a transcription factor involved in various cellular processes, including cell proliferation and differentiation. 6. **Long-term synaptic potentiation**: RASGRF2 regulates the activity of NMDA receptors, which are critical for long-term synaptic potentiation. 7. **Mapk1/Mapk3 signaling**: RASGRF2 regulates the activity of Mapk1 and Mapk3, which are involved in various cellular processes, including cell proliferation and differentiation. **Clinical Significance** RASGRF2 has been implicated in various neurological disorders, including: 1. **Neurodegenerative diseases**: RASGRF2 is involved in the regulation of cell death signaling pathways, which are critical for the development of neurodegenerative diseases, such as Alzheimer's disease and Parkinson's disease. 2. **Neuropsychiatric disorders**: RASGRF2 is involved in the regulation of neurotransmitter receptors and postsynaptic signal transmission, which are critical for the development of neuropsychiatric disorders, such as schizophrenia and bipolar disorder. 3. **Cancer**: RASGRF2 is involved in the regulation of cell proliferation and differentiation, which are critical for the development of cancer. 4. **Neurodevelopmental disorders**: RASGRF2 is involved in the regulation of neural development and function, which are critical for the development of neurodevelopmental disorders, such as autism spectrum disorder. In conclusion, RASGRF2 is a gene that encodes a protein involved in various cellular signaling pathways, including the regulation of neurotransmitter receptors and postsynaptic signal transmission. The gene has been implicated in various neurological disorders, including neurodegenerative diseases, neuropsychiatric disorders, cancer, and neurodevelopmental disorders. Further research is needed to understand the role of RASGRF2 in these disorders and to develop therapeutic strategies to target this gene.

Genular Protein ID: 2100277050

Symbol: RGRF2_HUMAN

Name: Ras-specific guanine nucleotide-releasing factor 2

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 10373510

Title: Ras-specific exchange factor GRF: oligomerization through its Dbl homology domain and calcium-dependent activation of Raf.

PubMed ID: 10373510

DOI: 10.1128/mcb.19.7.4611

PubMed ID: 11856323

Title: Dematin interacts with the Ras-guanine nucleotide exchange factor Ras-GRF2 and modulates mitogen-activated protein kinase pathways.

PubMed ID: 11856323

DOI: 10.1046/j.0014-2956.2001.02694.x

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 12176907

Title: Inhibitory effects of a dominant-interfering form of the Rho-GTPase Cdc42 in the chemoattractant-elicited signaling pathways leading to NADPH oxidase activation in differentiated HL-60 cells.

PubMed ID: 12176907

DOI: 10.1182/blood-2001-12-0193

PubMed ID: 15128856

Title: p35/cyclin-dependent kinase 5 phosphorylation of ras guanine nucleotide releasing factor 2 (RasGRF2) mediates Rac-dependent extracellular signal-regulated kinase 1/2 activity, altering RasGRF2 and microtubule-associated protein 1b distribution in neurons.

PubMed ID: 15128856

DOI: 10.1523/jneurosci.0690-04.2004

PubMed ID: 14749369

Title: Activation of H-Ras in the endoplasmic reticulum by the RasGRF family guanine nucleotide exchange factors.

PubMed ID: 14749369

DOI: 10.1128/mcb.24.4.1516-1530.2004

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 16959974

Title: The consensus coding sequences of human breast and colorectal cancers.

PubMed ID: 16959974

DOI: 10.1126/science.1133427

Sequence Information:

  • Length: 1237
  • Mass: 140764
  • Checksum: A136CF4FA111FDD9
  • Sequence:
  • MQKSVRYNEG HALYLAFLAR KEGTKRGFLS KKTAEASRWH EKWFALYQNV LFYFEGEQSC 
    RPAGMYLLEG CSCERTPAPP RAGAGQGGVR DALDKQYYFT VLFGHEGQKP LELRCEEEQD 
    GKEWMEAIHQ ASYADILIER EVLMQKYIHL VQIVETEKIA ANQLRHQLED QDTEIERLKS 
    EIIALNKTKE RMRPYQSNQE DEDPDIKKIK KVQSFMRGWL CRRKWKTIVQ DYICSPHAES 
    MRKRNQIVFT MVEAESEYVH QLYILVNGFL RPLRMAASSK KPPISHDDVS SIFLNSETIM 
    FLHEIFHQGL KARIANWPTL ILADLFDILL PMLNIYQEFV RNHQYSLQVL ANCKQNRDFD 
    KLLKQYEANP ACEGRMLETF LTYPMFQIPR YIITLHELLA HTPHEHVERK SLEFAKSKLE 
    ELSRVMHDEV SDTENIRKNL AIERMIVEGC DILLDTSQTF IRQGSLIQVP SVERGKLSKV 
    RLGSLSLKKE GERQCFLFTK HFLICTRSSG GKLHLLKTGG VLSLIDCTLI EEPDASDDDS 
    KGSGQVFGHL DFKIVVEPPD AAAFTVVLLA PSRQEKAAWM SDISQCVDNI RCNGLMTIVF 
    EENSKVTVPH MIKSDARLHK DDTDICFSKT LNSCKVPQIR YASVERLLER LTDLRFLSID 
    FLNTFLHTYR IFTTAAVVLG KLSDIYKRPF TSIPVRSLEL FFATSQNNRG EHLVDGKSPR 
    LCRKFSSPPP LAVSRTSSPV RARKLSLTSP LNSKIGALDL TTSSSPTTTT QSPAASPPPH 
    TGQIPLDLSR GLSSPEQSPG TVEENVDNPR VDLCNKLKRS IQKAVLESAP ADRAGVESSP 
    AADTTELSPC RSPSTPRHLR YRQPGGQTAD NAHCSVSPAS AFAIATAAAG HGSPPGFNNT 
    ERTCDKEFII RRTATNRVLN VLRHWVSKHA QDFELNNELK MNVLNLLEEV LRDPDLLPQE 
    RKAAANILRA LSQDDQDDIH LKLEDIIQMT DCMKAECFES LSAMELAEQI TLLDHVIFRS 
    IPYEEFLGQG WMKLDKNERT PYIMKTSQHF NDMSNLVASQ IMNYADVSSR ANAIEKWVAV 
    ADICRCLHNY NGVLEITSAL NRSAIYRLKK TWAKVSKQTK ALMDKLQKTV SSEGRFKNLR 
    ETLKNCNPPA VPYLGMYLTD LAFIEEGTPN FTEEGLVNFS KMRMISHIIR EIRQFQQTSY 
    RIDHQPKVAQ YLLDKDLIID EDTLYELSLK IEPRLPA

Genular Protein ID: 1691596948

Symbol: Q68DX5_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Sequence Information:

  • Length: 92
  • Mass: 10743
  • Checksum: 42AE58D41C709A03
  • Sequence:
  • CNPPAVPYLG MYLTDLAFIE EGTPNFTEEG LVNFSKMRMI SHIIREIRQF QQTSYRIDHQ 
    PKVAQYLLDK DLIIDEDTLY ELSLKIEPRL PA

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.