Details for: RASGRF2
Associated with
Cells (max top 100)
(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)
- Cell Name: polychromatophilic erythroblast (CL0000550)
Fold Change: 225.3364
Cell Significance Index: -35.0500 - Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
Fold Change: 138.9549
Cell Significance Index: -35.2500 - Cell Name: mucosal type mast cell (CL0000485)
Fold Change: 60.6759
Cell Significance Index: -24.6500 - Cell Name: orthochromatic erythroblast (CL0000552)
Fold Change: 28.4155
Cell Significance Index: -35.0400 - Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
Fold Change: 12.3069
Cell Significance Index: -37.8000 - Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
Fold Change: 12.0424
Cell Significance Index: -32.2600 - Cell Name: stromal cell of bone marrow (CL0010001)
Fold Change: 8.9267
Cell Significance Index: -35.2300 - Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: 8.5657
Cell Significance Index: 1245.1200 - Cell Name: epidermal Langerhans cell (CL0002457)
Fold Change: 7.8315
Cell Significance Index: -17.1400 - Cell Name: cardiac endothelial cell (CL0010008)
Fold Change: 6.7123
Cell Significance Index: 96.5400 - Cell Name: photoreceptor cell (CL0000210)
Fold Change: 5.6903
Cell Significance Index: 79.9200 - Cell Name: chandelier cell (CL4023083)
Fold Change: 3.4721
Cell Significance Index: 28.0400 - Cell Name: hippocampal granule cell (CL0001033)
Fold Change: 3.3574
Cell Significance Index: 225.7600 - Cell Name: hippocampal interneuron (CL1001569)
Fold Change: 2.7455
Cell Significance Index: 35.6100 - Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: 2.0788
Cell Significance Index: 417.0100 - Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: 1.7874
Cell Significance Index: 81.0200 - Cell Name: direct pathway medium spiny neuron (CL4023026)
Fold Change: 1.5870
Cell Significance Index: 60.1000 - Cell Name: forebrain neuroblast (CL1000042)
Fold Change: 1.5741
Cell Significance Index: 96.7500 - Cell Name: neoplastic cell (CL0001063)
Fold Change: 1.5407
Cell Significance Index: 305.7500 - Cell Name: hippocampal pyramidal neuron (CL1001571)
Fold Change: 1.5296
Cell Significance Index: 43.6500 - Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: 1.4497
Cell Significance Index: 2729.6700 - Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: 1.3537
Cell Significance Index: 257.6200 - Cell Name: eye photoreceptor cell (CL0000287)
Fold Change: 1.1554
Cell Significance Index: 72.8200 - Cell Name: indirect pathway medium spiny neuron (CL4023029)
Fold Change: 0.8573
Cell Significance Index: 37.9200 - Cell Name: colon goblet cell (CL0009039)
Fold Change: 0.8368
Cell Significance Index: 82.7800 - Cell Name: GABAergic interneuron (CL0011005)
Fold Change: 0.7979
Cell Significance Index: 551.8800 - Cell Name: tuft cell of colon (CL0009041)
Fold Change: 0.7878
Cell Significance Index: 711.3300 - Cell Name: retinal rod cell (CL0000604)
Fold Change: 0.7114
Cell Significance Index: 8.4800 - Cell Name: cortical interneuron (CL0008031)
Fold Change: 0.6809
Cell Significance Index: 16.3300 - Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: 0.6664
Cell Significance Index: 239.0200 - Cell Name: extravillous trophoblast (CL0008036)
Fold Change: 0.6293
Cell Significance Index: 3.9100 - Cell Name: lens epithelial cell (CL0002224)
Fold Change: 0.6268
Cell Significance Index: 964.9700 - Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: 0.6206
Cell Significance Index: 394.1600 - Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 0.4154
Cell Significance Index: 67.5600 - Cell Name: anterior lens cell (CL0002223)
Fold Change: 0.3721
Cell Significance Index: 686.3300 - Cell Name: secondary lens fiber (CL0002225)
Fold Change: 0.3447
Cell Significance Index: 468.7300 - Cell Name: retinal progenitor cell (CL0002672)
Fold Change: 0.2880
Cell Significance Index: 16.1600 - Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 0.2411
Cell Significance Index: 26.2200 - Cell Name: endothelial cell of placenta (CL0009092)
Fold Change: 0.1374
Cell Significance Index: 0.8300 - Cell Name: odontoblast (CL0000060)
Fold Change: 0.1201
Cell Significance Index: 15.4000 - Cell Name: L6 intratelencephalic projecting glutamatergic neuron of the primary motor cortex (CL4023050)
Fold Change: 0.0885
Cell Significance Index: 1.1800 - Cell Name: microfold cell of epithelium of small intestine (CL1000353)
Fold Change: 0.0649
Cell Significance Index: 4.4900 - Cell Name: sst GABAergic cortical interneuron (CL4023017)
Fold Change: 0.0642
Cell Significance Index: 1.2700 - Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 0.0507
Cell Significance Index: 1.4600 - Cell Name: lung endothelial cell (CL1001567)
Fold Change: 0.0394
Cell Significance Index: 2.0500 - Cell Name: enteroendocrine cell of small intestine (CL0009006)
Fold Change: 0.0208
Cell Significance Index: 0.5200 - Cell Name: adipocyte of breast (CL0002617)
Fold Change: 0.0000
Cell Significance Index: 0.0000 - Cell Name: small intestine goblet cell (CL1000495)
Fold Change: -0.0028
Cell Significance Index: -0.1000 - Cell Name: ciliary muscle cell (CL1000443)
Fold Change: -0.0239
Cell Significance Index: -10.8700 - Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
Fold Change: -0.0369
Cell Significance Index: -27.0600 - Cell Name: cell in vitro (CL0001034)
Fold Change: -0.0477
Cell Significance Index: -26.0700 - Cell Name: pancreatic A cell (CL0000171)
Fold Change: -0.0478
Cell Significance Index: -35.4100 - Cell Name: pulmonary alveolar epithelial cell (CL0000322)
Fold Change: -0.0482
Cell Significance Index: -36.4700 - Cell Name: kidney capillary endothelial cell (CL1000892)
Fold Change: -0.0492
Cell Significance Index: -0.5100 - Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
Fold Change: -0.0580
Cell Significance Index: -1.2300 - Cell Name: pancreatic PP cell (CL0002275)
Fold Change: -0.0599
Cell Significance Index: -37.4000 - Cell Name: type B pancreatic cell (CL0000169)
Fold Change: -0.0607
Cell Significance Index: -34.2600 - Cell Name: intermediate cell of urothelium (CL4030055)
Fold Change: -0.0669
Cell Significance Index: -12.0700 - Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
Fold Change: -0.0709
Cell Significance Index: -1.0200 - Cell Name: hair follicular keratinocyte (CL2000092)
Fold Change: -0.0855
Cell Significance Index: -37.8100 - Cell Name: dopaminergic neuron (CL0000700)
Fold Change: -0.0901
Cell Significance Index: -25.9200 - Cell Name: gut absorptive cell (CL0000677)
Fold Change: -0.1119
Cell Significance Index: -6.7200 - Cell Name: paneth cell of epithelium of small intestine (CL1000343)
Fold Change: -0.1149
Cell Significance Index: -2.4900 - Cell Name: abnormal cell (CL0001061)
Fold Change: -0.1341
Cell Significance Index: -13.7000 - Cell Name: cerebral cortex neuron (CL0010012)
Fold Change: -0.1377
Cell Significance Index: -1.3100 - Cell Name: leptomeningeal cell (CL0000708)
Fold Change: -0.1460
Cell Significance Index: -3.1200 - Cell Name: subcutaneous adipocyte (CL0002521)
Fold Change: -0.1482
Cell Significance Index: -0.6500 - Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: -0.1619
Cell Significance Index: -16.8600 - Cell Name: basal cell of urothelium (CL1000486)
Fold Change: -0.1655
Cell Significance Index: -20.3500 - Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
Fold Change: -0.1726
Cell Significance Index: -3.7300 - Cell Name: pancreatic D cell (CL0000173)
Fold Change: -0.1767
Cell Significance Index: -37.2100 - Cell Name: stromal cell of ovary (CL0002132)
Fold Change: -0.1807
Cell Significance Index: -24.8100 - Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: -0.2030
Cell Significance Index: -34.6700 - Cell Name: lactocyte (CL0002325)
Fold Change: -0.2464
Cell Significance Index: -31.8300 - Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
Fold Change: -0.2563
Cell Significance Index: -5.3500 - Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: -0.2655
Cell Significance Index: -20.3800 - Cell Name: VIP GABAergic cortical interneuron (CL4023016)
Fold Change: -0.2677
Cell Significance Index: -5.3800 - Cell Name: tonsil germinal center B cell (CL2000006)
Fold Change: -0.2794
Cell Significance Index: -32.9600 - Cell Name: eukaryotic cell (CL0000255)
Fold Change: -0.2965
Cell Significance Index: -12.8900 - Cell Name: epithelial cell of stomach (CL0002178)
Fold Change: -0.3034
Cell Significance Index: -35.3600 - Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: -0.3247
Cell Significance Index: -37.2000 - Cell Name: L6b glutamatergic cortical neuron (CL4023038)
Fold Change: -0.3381
Cell Significance Index: -11.0700 - Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
Fold Change: -0.3527
Cell Significance Index: -27.9300 - Cell Name: BEST4+ enteroycte (CL4030026)
Fold Change: -0.3630
Cell Significance Index: -5.4700 - Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: -0.3695
Cell Significance Index: -11.8400 - Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
Fold Change: -0.3743
Cell Significance Index: -11.9200 - Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
Fold Change: -0.4273
Cell Significance Index: -9.1000 - Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: -0.4283
Cell Significance Index: -31.9200 - Cell Name: cerebellar granule cell (CL0001031)
Fold Change: -0.4686
Cell Significance Index: -8.0300 - Cell Name: glutamatergic neuron (CL0000679)
Fold Change: -0.4755
Cell Significance Index: -5.1800 - Cell Name: early pro-B cell (CL0002046)
Fold Change: -0.4831
Cell Significance Index: -31.1700 - Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
Fold Change: -0.5001
Cell Significance Index: -17.5200 - Cell Name: oligodendrocyte (CL0000128)
Fold Change: -0.5036
Cell Significance Index: -5.4000 - Cell Name: intestinal tuft cell (CL0019032)
Fold Change: -0.5329
Cell Significance Index: -32.6700 - Cell Name: bladder urothelial cell (CL1001428)
Fold Change: -0.5421
Cell Significance Index: -28.1600 - Cell Name: glycinergic neuron (CL1001509)
Fold Change: -0.5626
Cell Significance Index: -29.5400 - Cell Name: sebum secreting cell (CL0000317)
Fold Change: -0.5627
Cell Significance Index: -39.8000 - Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
Fold Change: -0.5825
Cell Significance Index: -16.2800 - Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
Fold Change: -0.5989
Cell Significance Index: -28.1500 - Cell Name: tuft cell of small intestine (CL0009080)
Fold Change: -0.6057
Cell Significance Index: -6.1100
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Other Information
Genular Protein ID: 2100277050
Symbol: RGRF2_HUMAN
Name: Ras-specific guanine nucleotide-releasing factor 2
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 10373510
Title: Ras-specific exchange factor GRF: oligomerization through its Dbl homology domain and calcium-dependent activation of Raf.
PubMed ID: 10373510
PubMed ID: 11856323
Title: Dematin interacts with the Ras-guanine nucleotide exchange factor Ras-GRF2 and modulates mitogen-activated protein kinase pathways.
PubMed ID: 11856323
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 12176907
Title: Inhibitory effects of a dominant-interfering form of the Rho-GTPase Cdc42 in the chemoattractant-elicited signaling pathways leading to NADPH oxidase activation in differentiated HL-60 cells.
PubMed ID: 12176907
PubMed ID: 15128856
Title: p35/cyclin-dependent kinase 5 phosphorylation of ras guanine nucleotide releasing factor 2 (RasGRF2) mediates Rac-dependent extracellular signal-regulated kinase 1/2 activity, altering RasGRF2 and microtubule-associated protein 1b distribution in neurons.
PubMed ID: 15128856
PubMed ID: 14749369
Title: Activation of H-Ras in the endoplasmic reticulum by the RasGRF family guanine nucleotide exchange factors.
PubMed ID: 14749369
PubMed ID: 21406692
Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.
PubMed ID: 21406692
PubMed ID: 16959974
Title: The consensus coding sequences of human breast and colorectal cancers.
PubMed ID: 16959974
Sequence Information:
- Length: 1237
- Mass: 140764
- Checksum: A136CF4FA111FDD9
- Sequence:
MQKSVRYNEG HALYLAFLAR KEGTKRGFLS KKTAEASRWH EKWFALYQNV LFYFEGEQSC RPAGMYLLEG CSCERTPAPP RAGAGQGGVR DALDKQYYFT VLFGHEGQKP LELRCEEEQD GKEWMEAIHQ ASYADILIER EVLMQKYIHL VQIVETEKIA ANQLRHQLED QDTEIERLKS EIIALNKTKE RMRPYQSNQE DEDPDIKKIK KVQSFMRGWL CRRKWKTIVQ DYICSPHAES MRKRNQIVFT MVEAESEYVH QLYILVNGFL RPLRMAASSK KPPISHDDVS SIFLNSETIM FLHEIFHQGL KARIANWPTL ILADLFDILL PMLNIYQEFV RNHQYSLQVL ANCKQNRDFD KLLKQYEANP ACEGRMLETF LTYPMFQIPR YIITLHELLA HTPHEHVERK SLEFAKSKLE ELSRVMHDEV SDTENIRKNL AIERMIVEGC DILLDTSQTF IRQGSLIQVP SVERGKLSKV RLGSLSLKKE GERQCFLFTK HFLICTRSSG GKLHLLKTGG VLSLIDCTLI EEPDASDDDS KGSGQVFGHL DFKIVVEPPD AAAFTVVLLA PSRQEKAAWM SDISQCVDNI RCNGLMTIVF EENSKVTVPH MIKSDARLHK DDTDICFSKT LNSCKVPQIR YASVERLLER LTDLRFLSID FLNTFLHTYR IFTTAAVVLG KLSDIYKRPF TSIPVRSLEL FFATSQNNRG EHLVDGKSPR LCRKFSSPPP LAVSRTSSPV RARKLSLTSP LNSKIGALDL TTSSSPTTTT QSPAASPPPH TGQIPLDLSR GLSSPEQSPG TVEENVDNPR VDLCNKLKRS IQKAVLESAP ADRAGVESSP AADTTELSPC RSPSTPRHLR YRQPGGQTAD NAHCSVSPAS AFAIATAAAG HGSPPGFNNT ERTCDKEFII RRTATNRVLN VLRHWVSKHA QDFELNNELK MNVLNLLEEV LRDPDLLPQE RKAAANILRA LSQDDQDDIH LKLEDIIQMT DCMKAECFES LSAMELAEQI TLLDHVIFRS IPYEEFLGQG WMKLDKNERT PYIMKTSQHF NDMSNLVASQ IMNYADVSSR ANAIEKWVAV ADICRCLHNY NGVLEITSAL NRSAIYRLKK TWAKVSKQTK ALMDKLQKTV SSEGRFKNLR ETLKNCNPPA VPYLGMYLTD LAFIEEGTPN FTEEGLVNFS KMRMISHIIR EIRQFQQTSY RIDHQPKVAQ YLLDKDLIID EDTLYELSLK IEPRLPA
Genular Protein ID: 1691596948
Symbol: Q68DX5_HUMAN
Name: N/A
UniProtKB Accession Codes:
Database IDs:
Sequence Information:
- Length: 92
- Mass: 10743
- Checksum: 42AE58D41C709A03
- Sequence:
CNPPAVPYLG MYLTDLAFIE EGTPNFTEEG LVNFSKMRMI SHIIREIRQF QQTSYRIDHQ PKVAQYLLDK DLIIDEDTLY ELSLKIEPRL PA
Database document:
This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.