Details for: NAP1L4

Gene ID: 4676

Symbol: NAP1L4

Ensembl ID: ENSG00000205531

Description: nucleosome assembly protein 1 like 4

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 343.6621
    Cell Significance Index: -53.4600
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 239.8150
    Cell Significance Index: -60.8300
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 159.0979
    Cell Significance Index: -65.5400
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 154.0896
    Cell Significance Index: -62.6000
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 146.0002
    Cell Significance Index: -68.9300
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 131.0496
    Cell Significance Index: -67.4100
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 102.7686
    Cell Significance Index: -68.9600
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 65.9549
    Cell Significance Index: -62.9700
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 51.7010
    Cell Significance Index: -63.7500
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 20.4005
    Cell Significance Index: -54.6500
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 17.9293
    Cell Significance Index: -70.7500
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 17.4640
    Cell Significance Index: -53.6400
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 13.8400
    Cell Significance Index: -30.2900
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 6.9735
    Cell Significance Index: 173.9000
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 3.0003
    Cell Significance Index: 487.9800
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 2.8176
    Cell Significance Index: 507.9200
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 2.7380
    Cell Significance Index: 336.6600
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 2.4221
    Cell Significance Index: 480.6800
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 2.2208
    Cell Significance Index: 124.6200
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 2.1276
    Cell Significance Index: 56.8100
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 1.8227
    Cell Significance Index: 198.2600
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 1.6750
    Cell Significance Index: 46.8100
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 1.6705
    Cell Significance Index: 100.2900
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.6492
    Cell Significance Index: 330.8200
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 1.2983
    Cell Significance Index: 465.6700
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 1.2322
    Cell Significance Index: 1675.4900
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 1.1261
    Cell Significance Index: 1016.8100
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.0710
    Cell Significance Index: 55.6400
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 1.0432
    Cell Significance Index: 36.2500
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 1.0319
    Cell Significance Index: 30.3100
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: 1.0235
    Cell Significance Index: 15.1100
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.9897
    Cell Significance Index: 26.9400
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.9835
    Cell Significance Index: 135.0600
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.9095
    Cell Significance Index: 402.1000
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.8939
    Cell Significance Index: 105.4200
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.8806
    Cell Significance Index: 480.9400
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.8130
    Cell Significance Index: 23.4300
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.7707
    Cell Significance Index: 36.2200
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.7647
    Cell Significance Index: 58.6800
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.6788
    Cell Significance Index: 31.6500
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.6133
    Cell Significance Index: 32.2000
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 0.6130
    Cell Significance Index: 5.6500
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.6122
    Cell Significance Index: 27.7500
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.5621
    Cell Significance Index: 36.2700
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: 0.5284
    Cell Significance Index: 26.7000
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.4469
    Cell Significance Index: 11.7500
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.4405
    Cell Significance Index: 56.4700
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.3724
    Cell Significance Index: 26.3400
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.2849
    Cell Significance Index: 19.7100
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.2664
    Cell Significance Index: 410.1100
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.2576
    Cell Significance Index: 19.2000
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.2539
    Cell Significance Index: 16.0000
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.2501
    Cell Significance Index: 32.3100
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.2466
    Cell Significance Index: 454.7100
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.2462
    Cell Significance Index: 46.8600
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: 0.2127
    Cell Significance Index: 3.1400
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.1870
    Cell Significance Index: 9.7400
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 0.1745
    Cell Significance Index: 2.9900
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.1546
    Cell Significance Index: 291.0700
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 0.1101
    Cell Significance Index: 4.8700
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.1023
    Cell Significance Index: 64.9900
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.0527
    Cell Significance Index: 5.2100
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 0.0341
    Cell Significance Index: 1.2900
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.0260
    Cell Significance Index: 11.8000
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.0119
    Cell Significance Index: 8.7600
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 0.0097
    Cell Significance Index: 0.2500
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0480
    Cell Significance Index: -36.3300
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0512
    Cell Significance Index: -37.9400
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0569
    Cell Significance Index: -2.0000
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0573
    Cell Significance Index: -8.3300
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.1051
    Cell Significance Index: -59.2700
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.1213
    Cell Significance Index: -12.3900
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.1307
    Cell Significance Index: -81.6200
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.1422
    Cell Significance Index: -1.7000
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: -0.1568
    Cell Significance Index: -1.9500
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.1690
    Cell Significance Index: -28.8700
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.1827
    Cell Significance Index: -3.5700
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.2132
    Cell Significance Index: -24.8500
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.2140
    Cell Significance Index: -61.5700
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.2330
    Cell Significance Index: -3.9000
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.3424
    Cell Significance Index: -72.1200
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.4109
    Cell Significance Index: -47.0800
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.5211
    Cell Significance Index: -7.1100
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.5384
    Cell Significance Index: -56.0700
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.5630
    Cell Significance Index: -11.9900
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -0.5743
    Cell Significance Index: -3.4700
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.5968
    Cell Significance Index: -47.2700
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.6079
    Cell Significance Index: -17.4300
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.6217
    Cell Significance Index: -13.4700
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.6482
    Cell Significance Index: -16.5600
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -0.6606
    Cell Significance Index: -14.1200
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.7295
    Cell Significance Index: -15.2700
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.8459
    Cell Significance Index: -22.6700
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.9659
    Cell Significance Index: -30.9400
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.9775
    Cell Significance Index: -59.9300
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -1.1478
    Cell Significance Index: -24.3600
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -1.1600
    Cell Significance Index: -37.9800
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -1.1876
    Cell Significance Index: -37.8300
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: -1.3028
    Cell Significance Index: -21.9500
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -1.3259
    Cell Significance Index: -46.4500

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** NAP1L4 exhibits several key characteristics that are relevant to its function: 1. **Structural homology**: NAP1L4 shares significant structural homology with nucleosome assembly protein 1 (NAP1), a well-studied gene involved in chromatin assembly. 2. **Chromatin binding**: NAP1L4 binds to chromatin, suggesting its involvement in chromatin structure and organization. 3. **Histone binding**: NAP1L4 interacts with histones, which are essential components of chromatin, further supporting its role in chromatin assembly. 4. **Cell type specificity**: NAP1L4 is expressed in various cell types, including immune cells, epithelial cells, and neural cells, indicating its potential roles in different biological processes. **Pathways and Functions** NAP1L4 is involved in several pathways and functions, including: 1. **Chromatin assembly**: NAP1L4 contributes to the assembly of nucleosomes, which are the basic units of chromatin. 2. **Histone modification**: NAP1L4 may play a role in the regulation of histone modification, which is essential for gene expression and genome stability. 3. **Gene expression regulation**: By regulating chromatin structure and histone modification, NAP1L4 may influence gene expression and contribute to the development and function of various cell types. 4. **DNA repair**: NAP1L4 may also be involved in DNA repair mechanisms, as chromatin structure and histone modification are crucial for the repair of DNA damage. **Clinical Significance** The clinical significance of NAP1L4 is an area of ongoing research. However, the following potential implications have been proposed: 1. **Cancer**: Aberrant expression of NAP1L4 has been observed in various cancers, suggesting its potential role in tumorigenesis and cancer progression. 2. **Autoimmune diseases**: NAP1L4 may contribute to the development of autoimmune diseases, such as rheumatoid arthritis, by regulating chromatin structure and histone modification. 3. **Neurological disorders**: The expression of NAP1L4 in neural cells suggests its potential role in neurological disorders, such as Alzheimer's disease and Parkinson's disease. 4. **Gene therapy**: NAP1L4 may be a target for gene therapy approaches aimed at regulating chromatin structure and histone modification in the treatment of various diseases. In conclusion, NAP1L4 is a gene that plays a crucial role in chromatin structure and organization, and its dysregulation has been implicated in various diseases. Further research is needed to fully understand the functions and clinical significance of NAP1L4.

Genular Protein ID: 1804983970

Symbol: NP1L4_HUMAN

Name: Nucleosome assembly protein 1-like 4

UniProtKB Accession Codes:

Q99733 B2R6J4 F5HFY4

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CTD 1 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 5 Ensembl 6 ExpressionAtlas 1 GO 9 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 2 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MetOSite 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 RefSeq 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8923002

Title: A novel human homologue of yeast nucleosome assembly protein, 65 kb centromeric to the p57KIP2 gene, is biallelically expressed in fetal and adult tissues.

PubMed ID: 8923002

DOI: 10.1093/hmg/5.11.1743

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16554811

Title: Human chromosome 11 DNA sequence and analysis including novel gene identification.

PubMed ID: 16554811

DOI: 10.1038/nature04632

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9325046

Title: Functional characterization of human nucleosome assembly protein-2 (NAP1L4) suggests a role as a histone chaperone.

PubMed ID: 9325046

DOI: 10.1006/geno.1997.4868

PubMed ID: 10764593

Title: NAP-2: histone chaperone function and phosphorylation state through the cell cycle.

PubMed ID: 10764593

DOI: 10.1006/jmbi.2000.3674

PubMed ID: 17081983

Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.

PubMed ID: 17081983

DOI: 10.1016/j.cell.2006.09.026

PubMed ID: 17924679

Title: Improved titanium dioxide enrichment of phosphopeptides from HeLa cells and high confident phosphopeptide identification by cross-validation of MS/MS and MS/MS/MS spectra.

PubMed ID: 17924679

DOI: 10.1021/pr070152u

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 18318008

Title: Large-scale phosphoproteome analysis of human liver tissue by enrichment and fractionation of phosphopeptides with strong anion exchange chromatography.

PubMed ID: 18318008

DOI: 10.1002/pmic.200700884

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 22223895

Title: Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features.

PubMed ID: 22223895

DOI: 10.1074/mcp.m111.015131

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 29899097

Title: Multiple Host Factors Interact with the Hypervariable Domain of Chikungunya Virus nsP3 and Determine Viral Replication in Cell-Specific Mode.

PubMed ID: 29899097

DOI: 10.1128/jvi.00838-18

Sequence Information:

  • Length: 375
  • Mass: 42823
  • Checksum: 788E1F9F5BC8FD45
  • Sequence:
    • MADHSFSDGV PSDSVEAAKN ASNTEKLTDQ VMQNPRVLAA LQERLDNVPH TPSSYIETLP 
KAVKRRINAL KQLQVRCAHI EAKFYEEVHD LERKYAALYQ PLFDKRREFI TGDVEPTDAE 
SEWHSENEEE EKLAGDMKSK VVVTEKAAAT AEEPDPKGIP EFWFTIFRNV DMLSELVQEY 
DEPILKHLQD IKVKFSDPGQ PMSFVLEFHF EPNDYFTNSV LTKTYKMKSE PDKADPFSFE 
GPEIVDCDGC TIDWKKGKNV TVKTIKKKQK HKGRGTVRTI TKQVPNESFF NFFNPLKASG 
DGESLDEDSE FTLASDFEIG HFFRERIVPR AVLYFTGEAI EDDDNFEEGE EGEEEELEGD 
EEGEDEDDAE INPKV

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.