Details for: TF

Gene ID: 7018

Symbol: TF

Ensembl ID: ENSG00000091513

Description: transferrin

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 128.2585
    Cell Significance Index: -19.9500
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 78.6143
    Cell Significance Index: -19.9400
  • Cell Name: liver dendritic cell (CL2000055)
    Fold Change: 47.2355
    Cell Significance Index: 124.6100
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 40.2701
    Cell Significance Index: -16.3600
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 17.0622
    Cell Significance Index: -16.2900
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 10.0409
    Cell Significance Index: 1287.1900
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: 8.7875
    Cell Significance Index: 147.8000
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 8.0769
    Cell Significance Index: 136.0600
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 7.1553
    Cell Significance Index: -15.6600
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 5.2503
    Cell Significance Index: 1041.9500
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 4.7567
    Cell Significance Index: -18.7700
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 4.4733
    Cell Significance Index: 53.3300
  • Cell Name: midzonal region hepatocyte (CL0019028)
    Fold Change: 2.4181
    Cell Significance Index: 13.9300
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: 2.1931
    Cell Significance Index: 32.3700
  • Cell Name: intrahepatic cholangiocyte (CL0002538)
    Fold Change: 1.4922
    Cell Significance Index: 5.6200
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: 1.1196
    Cell Significance Index: 18.4500
  • Cell Name: Mueller cell (CL0000636)
    Fold Change: 0.6499
    Cell Significance Index: 5.0000
  • Cell Name: OFF-bipolar cell (CL0000750)
    Fold Change: 0.6374
    Cell Significance Index: 5.6200
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 0.6092
    Cell Significance Index: 15.6600
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.5754
    Cell Significance Index: 26.8300
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.5616
    Cell Significance Index: 112.6500
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.5498
    Cell Significance Index: 30.8500
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.4580
    Cell Significance Index: 14.6700
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.3806
    Cell Significance Index: 23.9900
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.2998
    Cell Significance Index: 107.5300
  • Cell Name: endothelial cell of pericentral hepatic sinusoid (CL0019022)
    Fold Change: 0.2445
    Cell Significance Index: 1.9300
  • Cell Name: epithelial cell of prostate (CL0002231)
    Fold Change: 0.1864
    Cell Significance Index: 1.1500
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.1598
    Cell Significance Index: 8.3900
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 0.1138
    Cell Significance Index: 7.6500
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.0427
    Cell Significance Index: 29.5600
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0162
    Cell Significance Index: 24.9500
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: 0.0149
    Cell Significance Index: 0.1600
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0107
    Cell Significance Index: 20.1500
  • Cell Name: hepatic pit cell (CL2000054)
    Fold Change: 0.0056
    Cell Significance Index: 0.0200
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0037
    Cell Significance Index: 6.7600
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0018
    Cell Significance Index: -2.3800
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0129
    Cell Significance Index: -0.3600
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0152
    Cell Significance Index: -9.6700
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0255
    Cell Significance Index: -18.6800
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0262
    Cell Significance Index: -19.8500
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0272
    Cell Significance Index: -3.9600
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0279
    Cell Significance Index: -20.6700
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0309
    Cell Significance Index: -3.9900
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0314
    Cell Significance Index: -17.1300
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0327
    Cell Significance Index: -14.8200
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0347
    Cell Significance Index: -21.6600
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0372
    Cell Significance Index: -21.0000
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: -0.0427
    Cell Significance Index: -18.9000
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0456
    Cell Significance Index: -13.1300
  • Cell Name: retinal bipolar neuron (CL0000748)
    Fold Change: -0.0709
    Cell Significance Index: -0.8600
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0737
    Cell Significance Index: -13.2800
  • Cell Name: cholangiocyte (CL1000488)
    Fold Change: -0.0791
    Cell Significance Index: -0.7800
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0838
    Cell Significance Index: -14.3100
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1022
    Cell Significance Index: -21.5300
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: -0.1056
    Cell Significance Index: -17.1700
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.1171
    Cell Significance Index: -7.2000
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.1226
    Cell Significance Index: -15.0800
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.1228
    Cell Significance Index: -16.8600
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.1282
    Cell Significance Index: -13.1000
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.1284
    Cell Significance Index: -9.5700
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.1393
    Cell Significance Index: -1.9000
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.1494
    Cell Significance Index: -17.6200
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.1546
    Cell Significance Index: -18.0200
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: -0.1562
    Cell Significance Index: -15.4500
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.1657
    Cell Significance Index: -2.8400
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1751
    Cell Significance Index: -20.0600
  • Cell Name: mucus secreting cell of tracheobronchial tree submucosal gland (CL4033037)
    Fold Change: -0.1767
    Cell Significance Index: -1.1800
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1807
    Cell Significance Index: -18.8100
  • Cell Name: basal epithelial cell of prostatic duct (CL0002236)
    Fold Change: -0.2264
    Cell Significance Index: -2.0100
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.2280
    Cell Significance Index: -4.7300
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.2301
    Cell Significance Index: -17.6600
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.2362
    Cell Significance Index: -18.7100
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.2534
    Cell Significance Index: -7.2300
  • Cell Name: ON-bipolar cell (CL0000749)
    Fold Change: -0.2602
    Cell Significance Index: -2.9400
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: -0.2604
    Cell Significance Index: -1.4200
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: -0.2607
    Cell Significance Index: -15.6500
  • Cell Name: endothelial cell of hepatic sinusoid (CL1000398)
    Fold Change: -0.2625
    Cell Significance Index: -2.5000
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.2644
    Cell Significance Index: -18.7000
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: -0.2715
    Cell Significance Index: -3.7700
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.2733
    Cell Significance Index: -14.2400
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.2821
    Cell Significance Index: -12.4800
  • Cell Name: hippocampal astrocyte (CL0002604)
    Fold Change: -0.2882
    Cell Significance Index: -4.0300
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.2959
    Cell Significance Index: -13.9100
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.3032
    Cell Significance Index: -19.5600
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.3035
    Cell Significance Index: -11.1400
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.3275
    Cell Significance Index: -10.4300
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.3487
    Cell Significance Index: -6.4500
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.3528
    Cell Significance Index: -15.9900
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.3628
    Cell Significance Index: -7.7000
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.3684
    Cell Significance Index: -13.9500
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: -0.3761
    Cell Significance Index: -4.6700
  • Cell Name: neural cell (CL0002319)
    Fold Change: -0.3772
    Cell Significance Index: -4.4000
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.4087
    Cell Significance Index: -8.8300
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.4087
    Cell Significance Index: -13.3800
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.4229
    Cell Significance Index: -8.4900
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.4265
    Cell Significance Index: -14.9400
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.4591
    Cell Significance Index: -19.9700
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.4662
    Cell Significance Index: -24.2200
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.4712
    Cell Significance Index: -11.3000
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.4784
    Cell Significance Index: -9.4600

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** 1. **Iron Binding**: Transferrin has two iron-binding sites, allowing it to transport iron ions from the bloodstream to tissues and cells. 2. **Glycoprotein Structure**: TF is a glycoprotein composed of two subunits (alpha-2 and beta-2) linked by a disulfide bridge. 3. **Cellular Expression**: TF is highly expressed in various cell types, including hepatocytes, enterocytes, endothelial cells, and oligodendrocytes. 4. **Iron Uptake and Transport**: TF plays a critical role in iron uptake and transport, facilitating the delivery of iron to tissues and cells. **Pathways and Functions** Transferrin is involved in various cellular pathways, including: 1. **Iron Ion Homeostasis**: TF regulates iron ion homeostasis by transporting iron ions from the bloodstream to tissues and cells. 2. **Cell Signaling**: TF interacts with receptors, such as the transferrin receptor, to modulate cell signaling pathways, including the Erk1 and Erk2 cascade. 3. **Protein Stability**: TF regulates protein stability by binding to and protecting proteins from degradation. 4. **Metabolism of Proteins**: TF is involved in the metabolism of proteins, including the regulation of insulin-like growth factor (IGF) transport and uptake. 5. **Vesicle-mediated Transport**: TF is involved in vesicle-mediated transport, facilitating the transport of small molecules and proteins. **Clinical Significance** Dysregulation of transferrin expression and function has been implicated in various diseases, including: 1. **Iron-Related Anemias**: TF plays a critical role in iron homeostasis, and dysregulation of TF expression can lead to iron-related anemias, such as iron deficiency anemia. 2. **Cancer**: TF has been implicated in cancer progression, including the regulation of cell motility, signaling, and protein stability. 3. **Neurological Disorders**: TF has been implicated in neurological disorders, including Alzheimer's disease and Parkinson's disease, where dysregulation of TF expression and function may contribute to disease progression. 4. **Cardiovascular Disease**: TF has been implicated in cardiovascular disease, including atherosclerosis, where dysregulation of TF expression and function may contribute to disease progression. In summary, transferrin is a critical protein involved in iron homeostasis, cell signaling, and protein stability, and dysregulation of TF expression and function has been implicated in various diseases. Further research is needed to fully understand the role of TF in human health and disease.

Genular Protein ID: 1656674642

Symbol: TRFE_HUMAN

Name: Beta-1 metal-binding globulin

UniProtKB Accession Codes:

P02787 O43890 Q1HBA5 Q9NQB8 Q9UHV0

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 2 CORUM 1 CPTAC 2 CTD 1 CarbonylDB 1 ChEBI 16 ChEMBL 1 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 33 DrugCentral 1 EMBL 43 EMDB 3 Ensembl 1 EvolutionaryTrace 1 ExpressionAtlas 1 GO 44 Gene3D 1 GeneCards 1 GeneWiki 1 GenomeRNAi 1 GlyConnect 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MEROPS 2 MIM 3 MINT 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 Orphanet 1 OrthoDB 1 PANTHER 2 PDB 52 PDBsum 52 PIR 1 PIRSF 2 PRIDE 1 PRINTS 1 PRO 1 PROSITE 4 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 REPRODUCTION-2DPAGE 2 RNAct 1 Reactome 7 RefSeq 1 SASBDB 1 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TopDownProteomics 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 6585826

Title: Human transferrin: cDNA characterization and chromosomal localization.

PubMed ID: 6585826

DOI: 10.1073/pnas.81.9.2752

PubMed ID: 3678832

Title: Complete structure of the human transferrin gene. Comparison with analogous chicken gene and human pseudogene.

PubMed ID: 3678832

DOI: 10.1016/0378-1119(87)90163-6

PubMed ID: 1809186

Title: A cloned gene for human transferrin.

PubMed ID: 1809186

DOI: 10.1111/j.1749-6632.1991.tb18573.x

PubMed ID: 11110675

Title: Molecular characterization of a case of atransferrinemia.

PubMed ID: 11110675

PubMed ID: 16641997

Title: The DNA sequence, annotation and analysis of human chromosome 3.

PubMed ID: 16641997

DOI: 10.1038/nature04728

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 3106157

Title: The human transferrin gene: 5' region contains conserved sequences which match the control elements regulated by heavy metals, glucocorticoids and acute phase reaction.

PubMed ID: 3106157

DOI: 10.1016/0378-1119(86)90277-5

PubMed ID: 3786138

Title: The 5' region of the human transferrin gene: structure and potential regulatory sites.

PubMed ID: 3786138

DOI: 10.1093/nar/14.21.8692

PubMed ID: 6833213

Title: The primary structure of human serum transferrin. The structures of seven cyanogen bromide fragments and the assembly of the complete structure.

PubMed ID: 6833213

DOI: 10.1016/s0021-9258(18)32696-6

PubMed ID: 10931525

Title: Alternative splicing prevents transferrin secretion during differentiation of a human oligodendrocyte cell line.

PubMed ID: 10931525

DOI: 10.1002/1097-4547(20000815)61:4<388::aid-jnr5>3.0.co;2-q

PubMed ID: 3858812

Title: Organization of the human transferrin gene: direct evidence that it originated by gene duplication.

PubMed ID: 3858812

DOI: 10.1073/pnas.82.10.3149

PubMed ID: 7498159

Title: The major protein expression profile and two-dimensional protein database of human heart.

PubMed ID: 7498159

DOI: 10.1002/elps.11501601192

PubMed ID: 6322780

Title: Molecular cloning and sequence analysis of cDNA for human transferrin.

PubMed ID: 6322780

DOI: 10.1016/0006-291x(84)91648-6

PubMed ID: 9272172

Title: Human transferrin (Tf): a single mutation at codon 570 determines Tf C1 or Tf C2 variant.

PubMed ID: 9272172

DOI: 10.1007/s004390050533

PubMed ID: 2780570

Title: Changes in brain gene expression shared by scrapie and Alzheimer disease.

PubMed ID: 2780570

DOI: 10.1073/pnas.86.18.7260

PubMed ID: 6953407

Title: The complete amino acid sequence of human serum transferrin.

PubMed ID: 6953407

DOI: 10.1073/pnas.79.8.2504

PubMed ID: 1932003

Title: Expression and initial characterization of five site-directed mutants of the N-terminal half-molecule of human transferrin.

PubMed ID: 1932003

DOI: 10.1021/bi00109a002

PubMed ID: 15084671

Title: A proteomic analysis of human bile.

PubMed ID: 15084671

DOI: 10.1074/mcp.m400015-mcp200

PubMed ID: 14760718

Title: Screening for N-glycosylated proteins by liquid chromatography mass spectrometry.

PubMed ID: 14760718

DOI: 10.1002/pmic.200300556

PubMed ID: 15536627

Title: Site-specific carbohydrate profiling of human transferrin by nano-flow liquid chromatography/electrospray ionization mass spectrometry.

PubMed ID: 15536627

DOI: 10.1002/rcm.1718

PubMed ID: 16335952

Title: Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry.

PubMed ID: 16335952

DOI: 10.1021/pr0502065

PubMed ID: 16740002

Title: Identification of N-linked glycoproteins in human saliva by glycoprotein capture and mass spectrometry.

PubMed ID: 16740002

DOI: 10.1021/pr050492k

PubMed ID: 19159218

Title: Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry.

PubMed ID: 19159218

DOI: 10.1021/pr8008012

PubMed ID: 19139490

Title: A strategy for precise and large scale identification of core fucosylated glycoproteins.

PubMed ID: 19139490

DOI: 10.1074/mcp.m800504-mcp200

PubMed ID: 19838169

Title: Enrichment of glycopeptides for glycan structure and attachment site identification.

PubMed ID: 19838169

DOI: 10.1038/nmeth.1392

PubMed ID: 22905912

Title: Resveratrol-induced changes of the human adipocyte secretion profile.

PubMed ID: 22905912

DOI: 10.1021/pr300539b

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 26091039

Title: A single kinase generates the majority of the secreted phosphoproteome.

PubMed ID: 26091039

DOI: 10.1016/j.cell.2015.05.028

PubMed ID: 37277838

Title: Apo- and holo-transferrin differentially interact with hephaestin and ferroportin in a novel mechanism of cellular iron release regulation.

PubMed ID: 37277838

DOI: 10.1186/s12929-023-00934-2

PubMed ID: 9609685

Title: Two high-resolution crystal structures of the recombinant N-lobe of human transferrin reveal a structural change implicated in iron release.

PubMed ID: 9609685

DOI: 10.1021/bi980355j

PubMed ID: 9760232

Title: Ligand-induced conformational change in transferrins: crystal structure of the open form of the N-terminal half-molecule of human transferrin.

PubMed ID: 9760232

DOI: 10.1021/bi9812064

PubMed ID: 10029548

Title: X-ray crystallography and mass spectroscopy reveal that the N-lobe of human transferrin expressed in Pichia pastoris is folded correctly but is glycosylated on serine-32.

PubMed ID: 10029548

DOI: 10.1021/bi9824543

PubMed ID: 22343719

Title: The structural basis of transferrin sequestration by transferrin-binding protein B.

PubMed ID: 22343719

DOI: 10.1038/nsmb.2251

PubMed ID: 22327295

Title: Structural basis for iron piracy by pathogenic Neisseria.

PubMed ID: 22327295

DOI: 10.1038/nature10823

PubMed ID: 31636418

Title: Structure of the trypanosome transferrin receptor reveals mechanisms of ligand recognition and immune evasion.

PubMed ID: 31636418

DOI: 10.1038/s41564-019-0589-0

PubMed ID: 9358047

Title: Exon/intron structure of the human transferrin receptor gene.

PubMed ID: 9358047

DOI: 10.1016/s0378-1119(97)00356-9

PubMed ID: 9803271

Title: Identification of a mutation (A1879G) of transferrin from cDNA prepared from peripheral blood cells.

PubMed ID: 9803271

DOI: 10.1046/j.1469-1809.1998.6230271.x

PubMed ID: 11703331

Title: Human transferrin G277S mutation: a risk factor for iron deficiency anaemia.

PubMed ID: 11703331

DOI: 10.1046/j.1365-2141.2001.03096.x

PubMed ID: 11702220

Title: Identification of 96 single nucleotide polymorphisms in eight genes involved in iron metabolism: efficiency of bioinformatic extraction compared with a systematic sequencing approach.

PubMed ID: 11702220

DOI: 10.1007/s004390100599

PubMed ID: 15466165

Title: Molecular characterization of a third case of human atransferrinemia.

PubMed ID: 15466165

DOI: 10.1182/blood-2004-05-1751

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

Sequence Information:

  • Length: 698
  • Mass: 77050
  • Checksum: 9A73BEAE8C567C79
  • Sequence:
    • MRLAVGALLV CAVLGLCLAV PDKTVRWCAV SEHEATKCQS FRDHMKSVIP SDGPSVACVK 
KASYLDCIRA IAANEADAVT LDAGLVYDAY LAPNNLKPVV AEFYGSKEDP QTFYYAVAVV 
KKDSGFQMNQ LRGKKSCHTG LGRSAGWNIP IGLLYCDLPE PRKPLEKAVA NFFSGSCAPC 
ADGTDFPQLC QLCPGCGCST LNQYFGYSGA FKCLKDGAGD VAFVKHSTIF ENLANKADRD 
QYELLCLDNT RKPVDEYKDC HLAQVPSHTV VARSMGGKED LIWELLNQAQ EHFGKDKSKE 
FQLFSSPHGK DLLFKDSAHG FLKVPPRMDA KMYLGYEYVT AIRNLREGTC PEAPTDECKP 
VKWCALSHHE RLKCDEWSVN SVGKIECVSA ETTEDCIAKI MNGEADAMSL DGGFVYIAGK 
CGLVPVLAEN YNKSDNCEDT PEAGYFAVAV VKKSASDLTW DNLKGKKSCH TAVGRTAGWN 
IPMGLLYNKI NHCRFDEFFS EGCAPGSKKD SSLCKLCMGS GLNLCEPNNK EGYYGYTGAF 
RCLVEKGDVA FVKHQTVPQN TGGKNPDPWA KNLNEKDYEL LCLDGTRKPV EEYANCHLAR 
APNHAVVTRK DKEACVHKIL RQQQHLFGSN VTDCSGNFCL FRSETKDLLF RDDTVCLAKL 
HDRNTYEKYL GEEYVKAVGN LRKCSTSSLL EACTFRRP

Genular Protein ID: 2509332386

Symbol: A0PJA6_HUMAN

Name: N/A

UniProtKB Accession Codes:

A0PJA6

Database IDs:

ARBA 6 AlphaFoldDB 1 BioGRID-ORCS 1 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 2 GO 8 Gene3D 1 InterPro 2 KEGG 1 MEROPS 2 NCBI Taxonomy 1 PANTHER 2 PRINTS 1 PROSITE 4 PeptideAtlas 1 Pfam 1 PharmGKB 1 RefSeq 1 SMART 1 SUPFAM 1

Citations:

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 180
  • Mass: 19908
  • Checksum: FFDFD94034D072C5
  • Sequence:
    • SGFQMNQLRG KKSCHTGLGR SAGWNIPIGL LYCDLPEPRK PLEKAVANFF SGSCAPCADG 
TDFPQLCQLC PGCGCSTLNQ YFGYSGAFKC LKDGAGDVAF VKHSTIFENL ANKADRDQYE 
LLCLDNTRKP VDEYKDCHLA QVPSHTVVAR SMGGKEDLIW ELLNQAQEHF GKKKKKKKKK

Genular Protein ID: 734664800

Symbol: Q06AH7_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q06AH7

Database IDs:

ARBA 15 AlphaFoldDB 1 BioGRID-ORCS 1 CDD 2 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 2 GO 9 Gene3D 1 IntAct 1 InterPro 4 KEGG 1 MEROPS 1 NCBI Taxonomy 1 PANTHER 2 PIRNR 1 PIRSF 2 PRINTS 1 PROSITE 5 Pfam 1 PharmGKB 1 RefSeq 1 SAM 1 SMART 1 SMR 1 SUPFAM 1

Sequence Information:

  • Length: 698
  • Mass: 76960
  • Checksum: F4DC27D4E96B3310
  • Sequence:
    • MRLAVGALLV CAVLGLCLAV PDKTVRWCAV SEHEATKCQS FRDHMKSVIP SDGPSVACVK 
KASYLDCIRA IAANEADAVT LDAGLVYDAY LAPNNLKPVV AEFYGSKEDP QTFYYAVAVV 
KKDSGFQMNQ LRGKKSCHTG LGRSAGWNIP IGLLYCDLPE PRKPLEKAVA NFFSGSCAPC 
ADGTDFPQLC QLCPGCGCST LNQYFGYSGA FKCLKDGAGD VAFVKHSTIF ENLANKADRD 
QYELLCLDNT RKPVDEYKDC HLAQVPSHTV VARSIGGKED LIWELLNQAQ EHFGKDKSKE 
FQLFSSPHGK DLLFKDSAHG FLKVPPRMDA KMYLGYEYVT AIRNLREGTC PEAPTDECKP 
VKWCALSHHE RLKCDEWSVN SVGKIECVSA ETTEDCIAKI MNGEADAMSL DGGFVYIAGK 
CGLVPVLAEN YNKSDNCEDT PGAGYFAVAV VKKSASDLTW DNLKGKKSCH TAVGRTAGWN 
IPMGLLYNKI NHCRFDEFFS EGCAPGSKKD SSLCKLCMGS GLNLCEPNNK EGYYGYTGAF 
RCLVEKGDVA FVKHQTVPQN TGGKNPDPWA KNLNEKDYEL LCLDGTRKPV EEYANCHLAR 
APNHAVVTRK DKEACVHKIL RQQQHLFGSN VTDCSGNFCL FRSETKDLLF RDDTVCLAKL 
HDRNTYEKYL GEEYVKAVGN LRKCSTSSLL EACTFRRP

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.