Details for: SLCO1A2
Associated with
Cells (max top 100)
(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)
- Cell Name: epithelial cell of pancreas (CL0000083)
Fold Change: 1.6257
Cell Significance Index: 26.7900 - Cell Name: serous secreting cell of bronchus submucosal gland (CL4033005)
Fold Change: 0.8734
Cell Significance Index: 8.7400 - Cell Name: neoplastic cell (CL0001063)
Fold Change: 0.8265
Cell Significance Index: 164.0300 - Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
Fold Change: 0.8141
Cell Significance Index: 19.7200 - Cell Name: hepatoblast (CL0005026)
Fold Change: 0.6564
Cell Significance Index: 11.0400 - Cell Name: pancreatic epsilon cell (CL0005019)
Fold Change: 0.6476
Cell Significance Index: 6.0000 - Cell Name: epithelial cell of stomach (CL0002178)
Fold Change: 0.2252
Cell Significance Index: 26.2500 - Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: 0.0149
Cell Significance Index: 5.3400 - Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: 0.0119
Cell Significance Index: 2.3900 - Cell Name: centrilobular region hepatocyte (CL0019029)
Fold Change: 0.0071
Cell Significance Index: 0.1200 - Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: -0.0022
Cell Significance Index: -4.2000 - Cell Name: oligodendrocyte (CL0000128)
Fold Change: -0.0028
Cell Significance Index: -0.0300 - Cell Name: pancreatic A cell (CL0000171)
Fold Change: -0.0031
Cell Significance Index: -2.3000 - Cell Name: anterior lens cell (CL0002223)
Fold Change: -0.0044
Cell Significance Index: -8.0700 - Cell Name: GABAergic interneuron (CL0011005)
Fold Change: -0.0047
Cell Significance Index: -3.2600 - Cell Name: lens epithelial cell (CL0002224)
Fold Change: -0.0055
Cell Significance Index: -8.5000 - Cell Name: secondary lens fiber (CL0002225)
Fold Change: -0.0062
Cell Significance Index: -8.4300 - Cell Name: lactocyte (CL0002325)
Fold Change: -0.0067
Cell Significance Index: -0.8700 - Cell Name: type B pancreatic cell (CL0000169)
Fold Change: -0.0076
Cell Significance Index: -4.3100 - Cell Name: pulmonary alveolar epithelial cell (CL0000322)
Fold Change: -0.0101
Cell Significance Index: -7.6300 - Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: -0.0113
Cell Significance Index: -7.1700 - Cell Name: cell in vitro (CL0001034)
Fold Change: -0.0134
Cell Significance Index: -7.3000 - Cell Name: pancreatic PP cell (CL0002275)
Fold Change: -0.0137
Cell Significance Index: -8.5600 - Cell Name: ciliary muscle cell (CL1000443)
Fold Change: -0.0153
Cell Significance Index: -6.9400 - Cell Name: dopaminergic neuron (CL0000700)
Fold Change: -0.0168
Cell Significance Index: -4.8300 - Cell Name: intermediate cell of urothelium (CL4030055)
Fold Change: -0.0350
Cell Significance Index: -6.3200 - Cell Name: pancreatic D cell (CL0000173)
Fold Change: -0.0351
Cell Significance Index: -7.3900 - Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: -0.0427
Cell Significance Index: -6.2000 - Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
Fold Change: -0.0429
Cell Significance Index: -2.0200 - Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: -0.0469
Cell Significance Index: -8.0100 - Cell Name: stromal cell of ovary (CL0002132)
Fold Change: -0.0541
Cell Significance Index: -7.4300 - Cell Name: basal cell of urothelium (CL1000486)
Fold Change: -0.0545
Cell Significance Index: -6.7000 - Cell Name: hippocampal granule cell (CL0001033)
Fold Change: -0.0574
Cell Significance Index: -3.8600 - Cell Name: neuron associated cell (CL0000095)
Fold Change: -0.0665
Cell Significance Index: -2.7300 - Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: -0.0690
Cell Significance Index: -7.1800 - Cell Name: abnormal cell (CL0001061)
Fold Change: -0.0771
Cell Significance Index: -7.8800 - Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: -0.0771
Cell Significance Index: -8.8400 - Cell Name: periportal region hepatocyte (CL0019026)
Fold Change: -0.0854
Cell Significance Index: -1.2600 - Cell Name: hippocampal astrocyte (CL0002604)
Fold Change: -0.0865
Cell Significance Index: -1.2100 - Cell Name: forebrain neuroblast (CL1000042)
Fold Change: -0.1009
Cell Significance Index: -6.2000 - Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: -0.1031
Cell Significance Index: -7.9200 - Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: -0.1037
Cell Significance Index: -7.7300 - Cell Name: retinal pigment epithelial cell (CL0002586)
Fold Change: -0.1125
Cell Significance Index: -1.2100 - Cell Name: lung endothelial cell (CL1001567)
Fold Change: -0.1271
Cell Significance Index: -6.6200 - Cell Name: indirect pathway medium spiny neuron (CL4023029)
Fold Change: -0.1273
Cell Significance Index: -5.6300 - Cell Name: cerebellar granule cell (CL0001031)
Fold Change: -0.1278
Cell Significance Index: -2.1900 - Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: -0.1319
Cell Significance Index: -6.1500 - Cell Name: intestinal tuft cell (CL0019032)
Fold Change: -0.1377
Cell Significance Index: -8.4400 - Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
Fold Change: -0.1419
Cell Significance Index: -2.0300 - Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
Fold Change: -0.1507
Cell Significance Index: -5.2800 - Cell Name: retinal progenitor cell (CL0002672)
Fold Change: -0.1518
Cell Significance Index: -8.5200 - Cell Name: direct pathway medium spiny neuron (CL4023026)
Fold Change: -0.1534
Cell Significance Index: -5.8100 - Cell Name: cytotoxic T cell (CL0000910)
Fold Change: -0.1674
Cell Significance Index: -2.4400 - Cell Name: bladder urothelial cell (CL1001428)
Fold Change: -0.1729
Cell Significance Index: -8.9800 - Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
Fold Change: -0.1812
Cell Significance Index: -5.7700 - Cell Name: L6b glutamatergic cortical neuron (CL4023038)
Fold Change: -0.1842
Cell Significance Index: -6.0300 - Cell Name: neural cell (CL0002319)
Fold Change: -0.1860
Cell Significance Index: -2.1700 - Cell Name: cerebral cortex endothelial cell (CL1001602)
Fold Change: -0.2089
Cell Significance Index: -4.2500 - Cell Name: hippocampal pyramidal neuron (CL1001571)
Fold Change: -0.2117
Cell Significance Index: -6.0400 - Cell Name: eukaryotic cell (CL0000255)
Fold Change: -0.2141
Cell Significance Index: -9.3100 - Cell Name: thymocyte (CL0000893)
Fold Change: -0.2153
Cell Significance Index: -2.7200 - Cell Name: cerebral cortex neuron (CL0010012)
Fold Change: -0.2291
Cell Significance Index: -2.1800 - Cell Name: small intestine goblet cell (CL1000495)
Fold Change: -0.2319
Cell Significance Index: -8.1500 - Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
Fold Change: -0.2337
Cell Significance Index: -5.8300 - Cell Name: kidney epithelial cell (CL0002518)
Fold Change: -0.2478
Cell Significance Index: -7.3000 - Cell Name: fibro/adipogenic progenitor cell (CL0009099)
Fold Change: -0.2492
Cell Significance Index: -12.5900 - Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
Fold Change: -0.2555
Cell Significance Index: -7.1400 - Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
Fold Change: -0.2617
Cell Significance Index: -5.6600 - Cell Name: astrocyte of the cerebral cortex (CL0002605)
Fold Change: -0.2620
Cell Significance Index: -4.5300 - Cell Name: cortical cell of adrenal gland (CL0002097)
Fold Change: -0.2698
Cell Significance Index: -7.2300 - Cell Name: neutrophil progenitor cell (CL0000834)
Fold Change: -0.2729
Cell Significance Index: -7.3000 - Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: -0.2737
Cell Significance Index: -7.8900 - Cell Name: fibroblast of mammary gland (CL0002555)
Fold Change: -0.2742
Cell Significance Index: -7.8600 - Cell Name: placental villous trophoblast (CL2000060)
Fold Change: -0.2745
Cell Significance Index: -7.3300 - Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
Fold Change: -0.2766
Cell Significance Index: -5.8700 - Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
Fold Change: -0.2784
Cell Significance Index: -5.8100 - Cell Name: epithelial cell of nephron (CL1000449)
Fold Change: -0.2788
Cell Significance Index: -2.3700 - Cell Name: VIP GABAergic cortical interneuron (CL4023016)
Fold Change: -0.2843
Cell Significance Index: -5.7100 - Cell Name: granulosa cell (CL0000501)
Fold Change: -0.2907
Cell Significance Index: -7.6500 - Cell Name: lens fiber cell (CL0011004)
Fold Change: -0.2937
Cell Significance Index: -9.2900 - Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
Fold Change: -0.2959
Cell Significance Index: -7.3800 - Cell Name: cortical interneuron (CL0008031)
Fold Change: -0.3021
Cell Significance Index: -7.2500 - Cell Name: Purkinje cell (CL0000121)
Fold Change: -0.3064
Cell Significance Index: -6.7100 - Cell Name: sst GABAergic cortical interneuron (CL4023017)
Fold Change: -0.3110
Cell Significance Index: -6.1500 - Cell Name: enteroendocrine cell of small intestine (CL0009006)
Fold Change: -0.3180
Cell Significance Index: -7.9500 - Cell Name: glial cell (CL0000125)
Fold Change: -0.3181
Cell Significance Index: -3.4900 - Cell Name: macroglial cell (CL0000126)
Fold Change: -0.3196
Cell Significance Index: -3.7000 - Cell Name: erythrocyte (CL0000232)
Fold Change: -0.3199
Cell Significance Index: -8.1500 - Cell Name: sncg GABAergic cortical interneuron (CL4023015)
Fold Change: -0.3219
Cell Significance Index: -6.3400 - Cell Name: type I muscle cell (CL0002211)
Fold Change: -0.3307
Cell Significance Index: -8.0700 - Cell Name: pyramidal neuron (CL0000598)
Fold Change: -0.3364
Cell Significance Index: -2.5800 - Cell Name: brain vascular cell (CL4023072)
Fold Change: -0.3410
Cell Significance Index: -3.9000 - Cell Name: germ cell (CL0000586)
Fold Change: -0.3417
Cell Significance Index: -2.5800 - Cell Name: basal cell of prostate epithelium (CL0002341)
Fold Change: -0.3593
Cell Significance Index: -9.7800 - Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
Fold Change: -0.3681
Cell Significance Index: -7.3400 - Cell Name: transit amplifying cell of small intestine (CL0009012)
Fold Change: -0.3731
Cell Significance Index: -7.7400 - Cell Name: basal cell of epidermis (CL0002187)
Fold Change: -0.3812
Cell Significance Index: -5.7900 - Cell Name: endocrine cell (CL0000163)
Fold Change: -0.3835
Cell Significance Index: -4.6400 - Cell Name: hippocampal interneuron (CL1001569)
Fold Change: -0.3848
Cell Significance Index: -4.9900 - Cell Name: luminal epithelial cell of mammary gland (CL0002326)
Fold Change: -0.3898
Cell Significance Index: -5.0200
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Other Information
Genular Protein ID: 1152922612
Symbol: SO1A2_HUMAN
Name: Solute carrier organic anion transporter family member 1A2
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 7557095
Title: Molecular and functional characterization of an organic anion transporting polypeptide cloned from human liver.
PubMed ID: 7557095
PubMed ID: 10779507
Title: Localization and genomic organization of a new hepatocellular organic anion transporting polypeptide.
PubMed ID: 10779507
PubMed ID: 11238933
Title: Antisense promoter of human L1 retrotransposon drives transcription of adjacent cellular genes.
PubMed ID: 11238933
PubMed ID: 9539145
Title: Dehydroepiandrosterone sulfate (DHEAS): identification of a carrier protein in human liver and brain.
PubMed ID: 9539145
PubMed ID: 10873595
Title: Molecular identification and characterization of novel members of the human organic anion transporter (OATP) family.
PubMed ID: 10873595
PubMed ID: 11159893
Title: Organic anion-transporting polypeptide B (OATP-B) and its functional comparison with three other OATPs of human liver.
PubMed ID: 11159893
PubMed ID: 12409283
Title: Characterization and identification of steroid sulfate transporters of human placenta.
PubMed ID: 12409283
PubMed ID: 12568656
Title: Role of organic anion-transporting polypeptides, OATP-A, OATP-C and OATP-8, in the human placenta-maternal liver tandem excretory pathway for foetal bilirubin.
PubMed ID: 12568656
DOI: 10.1042/bj20030034
PubMed ID: 17301733
Title: Naringin is a major and selective clinical inhibitor of organic anion-transporting polypeptide 1A2 (OATP1A2) in grapefruit juice.
PubMed ID: 17301733
PubMed ID: 19129463
Title: Mechanisms of pH-gradient driven transport mediated by organic anion polypeptide transporters.
PubMed ID: 19129463
PubMed ID: 20358049
Title: Transport of thyroid hormones is selectively inhibited by 3-iodothyronamine.
PubMed ID: 20358049
DOI: 10.1039/b926588k
PubMed ID: 20686826
Title: Intestinal absorption of HMG-CoA reductase inhibitor pravastatin mediated by organic anion transporting polypeptide.
PubMed ID: 20686826
PubMed ID: 23918469
Title: Functional analysis of novel polymorphisms in the human SLCO1A2 gene that encodes the transporter OATP1A2.
PubMed ID: 23918469
PubMed ID: 23243220
Title: Influence of human OATP1B1, OATP1B3, and OATP1A2 on the pharmacokinetics of methotrexate and paclitaxel in humanized transgenic mice.
PubMed ID: 23243220
PubMed ID: 25560245
Title: Human organic anion transporting polypeptide 1A2 (OATP1A2) mediates cellular uptake of all-trans-retinol in human retinal pigmented epithelial cells.
PubMed ID: 25560245
DOI: 10.1111/bph.13060
PubMed ID: 25132355
Title: Differential cellular expression of organic anion transporting peptides OATP1A2 and OATP2B1 in the human retina and brain: implications for carrier-mediated transport of neuropeptides and neurosteriods in the CNS.
PubMed ID: 25132355
PubMed ID: 27777271
Title: Contribution of Organic Anion-Transporting Polypeptides 1A/1B to Doxorubicin Uptake and Clearance.
PubMed ID: 27777271
PubMed ID: 35307651
Title: Localization of Xenobiotic Transporters Expressed at the Human Blood-Testis Barrier.
PubMed ID: 35307651
PubMed ID: 15632119
Title: Polymorphisms in human organic anion-transporting polypeptide 1A2 (OATP1A2): implications for altered drug disposition and central nervous system drug entry.
PubMed ID: 15632119
PubMed ID: 16959974
Title: The consensus coding sequences of human breast and colorectal cancers.
PubMed ID: 16959974
Sequence Information:
- Length: 670
- Mass: 74145
- Checksum: C3A740CEF1E6F129
- Sequence:
MGETEKRIET HRIRCLSKLK MFLLAITCAF VSKTLSGSYM NSMLTQIERQ FNIPTSLVGF INGSFEIGNL LLIIFVSYFG TKLHRPIMIG IGCVVMGLGC FLKSLPHFLM NQYEYESTVS VSGNLSSNSF LCMENGTQIL RPTQDPSECT KEVKSLMWVY VLVGNIVRGM GETPILPLGI SYIEDFAKFE NSPLYIGLVE TGAIIGPLIG LLLASFCANV YVDTGFVNTD DLIITPTDTR WVGAWWFGFL ICAGVNVLTA IPFFFLPNTL PKEGLETNAD IIKNENEDKQ KEEVKKEKYG ITKDFLPFMK SLSCNPIYML FILVSVIQFN AFVNMISFMP KYLEQQYGIS SSDAIFLMGI YNLPPICIGY IIGGLIMKKF KITVKQAAHI GCWLSLLEYL LYFLSFLMTC ENSSVVGINT SYEGIPQDLY VENDIFADCN VDCNCPSKIW DPVCGNNGLS YLSACLAGCE TSIGTGINMV FQNCSCIQTS GNSSAVLGLC DKGPDCSLML QYFLILSAMS SFIYSLAAIP GYMVLLRCMK SEEKSLGVGL HTFCTRVFAG IPAPIYFGAL MDSTCLHWGT LKCGESGACR IYDSTTFRYI YLGLPAALRG SSFVPALIIL ILLRKCHLPG ENASSGTELI ETKVKGKENE CKDIYQKSTV LKDDELKTKL
Database document:
This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.