Details for: SLCO1A2

Gene ID: 6579

Symbol: SLCO1A2

Ensembl ID: ENSG00000084453

Description: solute carrier organic anion transporter family member 1A2

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: 1.6257
    Cell Significance Index: 26.7900
  • Cell Name: serous secreting cell of bronchus submucosal gland (CL4033005)
    Fold Change: 0.8734
    Cell Significance Index: 8.7400
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.8265
    Cell Significance Index: 164.0300
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: 0.8141
    Cell Significance Index: 19.7200
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: 0.6564
    Cell Significance Index: 11.0400
  • Cell Name: pancreatic epsilon cell (CL0005019)
    Fold Change: 0.6476
    Cell Significance Index: 6.0000
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.2252
    Cell Significance Index: 26.2500
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0149
    Cell Significance Index: 5.3400
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.0119
    Cell Significance Index: 2.3900
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 0.0071
    Cell Significance Index: 0.1200
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0022
    Cell Significance Index: -4.2000
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: -0.0028
    Cell Significance Index: -0.0300
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0031
    Cell Significance Index: -2.3000
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0044
    Cell Significance Index: -8.0700
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: -0.0047
    Cell Significance Index: -3.2600
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0055
    Cell Significance Index: -8.5000
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0062
    Cell Significance Index: -8.4300
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0067
    Cell Significance Index: -0.8700
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0076
    Cell Significance Index: -4.3100
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0101
    Cell Significance Index: -7.6300
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0113
    Cell Significance Index: -7.1700
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0134
    Cell Significance Index: -7.3000
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0137
    Cell Significance Index: -8.5600
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0153
    Cell Significance Index: -6.9400
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0168
    Cell Significance Index: -4.8300
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0350
    Cell Significance Index: -6.3200
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0351
    Cell Significance Index: -7.3900
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0427
    Cell Significance Index: -6.2000
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0429
    Cell Significance Index: -2.0200
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0469
    Cell Significance Index: -8.0100
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0541
    Cell Significance Index: -7.4300
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0545
    Cell Significance Index: -6.7000
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0574
    Cell Significance Index: -3.8600
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0665
    Cell Significance Index: -2.7300
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0690
    Cell Significance Index: -7.1800
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0771
    Cell Significance Index: -7.8800
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0771
    Cell Significance Index: -8.8400
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: -0.0854
    Cell Significance Index: -1.2600
  • Cell Name: hippocampal astrocyte (CL0002604)
    Fold Change: -0.0865
    Cell Significance Index: -1.2100
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.1009
    Cell Significance Index: -6.2000
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.1031
    Cell Significance Index: -7.9200
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.1037
    Cell Significance Index: -7.7300
  • Cell Name: retinal pigment epithelial cell (CL0002586)
    Fold Change: -0.1125
    Cell Significance Index: -1.2100
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.1271
    Cell Significance Index: -6.6200
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.1273
    Cell Significance Index: -5.6300
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.1278
    Cell Significance Index: -2.1900
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.1319
    Cell Significance Index: -6.1500
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.1377
    Cell Significance Index: -8.4400
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.1419
    Cell Significance Index: -2.0300
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.1507
    Cell Significance Index: -5.2800
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.1518
    Cell Significance Index: -8.5200
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.1534
    Cell Significance Index: -5.8100
  • Cell Name: cytotoxic T cell (CL0000910)
    Fold Change: -0.1674
    Cell Significance Index: -2.4400
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.1729
    Cell Significance Index: -8.9800
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.1812
    Cell Significance Index: -5.7700
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.1842
    Cell Significance Index: -6.0300
  • Cell Name: neural cell (CL0002319)
    Fold Change: -0.1860
    Cell Significance Index: -2.1700
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: -0.2089
    Cell Significance Index: -4.2500
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.2117
    Cell Significance Index: -6.0400
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.2141
    Cell Significance Index: -9.3100
  • Cell Name: thymocyte (CL0000893)
    Fold Change: -0.2153
    Cell Significance Index: -2.7200
  • Cell Name: cerebral cortex neuron (CL0010012)
    Fold Change: -0.2291
    Cell Significance Index: -2.1800
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.2319
    Cell Significance Index: -8.1500
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.2337
    Cell Significance Index: -5.8300
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.2478
    Cell Significance Index: -7.3000
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.2492
    Cell Significance Index: -12.5900
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.2555
    Cell Significance Index: -7.1400
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.2617
    Cell Significance Index: -5.6600
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -0.2620
    Cell Significance Index: -4.5300
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.2698
    Cell Significance Index: -7.2300
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.2729
    Cell Significance Index: -7.3000
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.2737
    Cell Significance Index: -7.8900
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.2742
    Cell Significance Index: -7.8600
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.2745
    Cell Significance Index: -7.3300
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.2766
    Cell Significance Index: -5.8700
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.2784
    Cell Significance Index: -5.8100
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: -0.2788
    Cell Significance Index: -2.3700
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.2843
    Cell Significance Index: -5.7100
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.2907
    Cell Significance Index: -7.6500
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: -0.2937
    Cell Significance Index: -9.2900
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: -0.2959
    Cell Significance Index: -7.3800
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.3021
    Cell Significance Index: -7.2500
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.3064
    Cell Significance Index: -6.7100
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.3110
    Cell Significance Index: -6.1500
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.3180
    Cell Significance Index: -7.9500
  • Cell Name: glial cell (CL0000125)
    Fold Change: -0.3181
    Cell Significance Index: -3.4900
  • Cell Name: macroglial cell (CL0000126)
    Fold Change: -0.3196
    Cell Significance Index: -3.7000
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.3199
    Cell Significance Index: -8.1500
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: -0.3219
    Cell Significance Index: -6.3400
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: -0.3307
    Cell Significance Index: -8.0700
  • Cell Name: pyramidal neuron (CL0000598)
    Fold Change: -0.3364
    Cell Significance Index: -2.5800
  • Cell Name: brain vascular cell (CL4023072)
    Fold Change: -0.3410
    Cell Significance Index: -3.9000
  • Cell Name: germ cell (CL0000586)
    Fold Change: -0.3417
    Cell Significance Index: -2.5800
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.3593
    Cell Significance Index: -9.7800
  • Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
    Fold Change: -0.3681
    Cell Significance Index: -7.3400
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.3731
    Cell Significance Index: -7.7400
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: -0.3812
    Cell Significance Index: -5.7900
  • Cell Name: endocrine cell (CL0000163)
    Fold Change: -0.3835
    Cell Significance Index: -4.6400
  • Cell Name: hippocampal interneuron (CL1001569)
    Fold Change: -0.3848
    Cell Significance Index: -4.9900
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: -0.3898
    Cell Significance Index: -5.0200

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Transport Function:** SLCO1A2 is a sodium-independent organic anion transporter that facilitates the transport of a wide range of organic anions, including bile acids, steroids, and vitamins, across cell membranes. 2. **Tissue Expression:** SLCO1A2 is highly expressed in cells involved in bile acid and steroid metabolism, including the liver, intestine, and brain. 3. **Genetic Variability:** Variations in the SLCO1A2 gene have been associated with altered bile acid and steroid metabolism, which can impact various physiological processes. 4. **Pharmacokinetics:** SLCO1A2 plays a critical role in the pharmacokinetics of certain drugs, including ciprofloxacin, which is affected by SLCO1A2-mediated transport. **Pathways and Functions:** 1. **Bile Acid and Steroid Metabolism:** SLCO1A2 facilitates the transport of bile acids and steroids across cell membranes, regulating their metabolism and homeostasis. 2. **Lipid and Steroid Metabolism:** SLCO1A2 influences lipid and steroid metabolism by regulating the transport of these molecules across cell membranes. 3. **Ciprofloxacin Pharmacokinetics:** SLCO1A2-mediated transport affects the pharmacokinetics of ciprofloxacin, a widely used antibiotic. 4. **Vitamin and Nucleoside Transport:** SLCO1A2 also facilitates the transport of vitamins, nucleosides, and related molecules across cell membranes. **Clinical Significance:** Variations in the SLCO1A2 gene have significant clinical implications, including: 1. **Bile Acid and Steroid Metabolic Disorders:** Altered SLCO1A2 function can lead to bile acid and steroid metabolic disorders, such as primary biliary cholangitis and steroid-resistant nephrotic syndrome. 2. **Pharmacokinetic Variability:** SLCO1A2-mediated transport can affect the pharmacokinetics of certain drugs, including ciprofloxacin, which can impact treatment outcomes. 3. **Nutritional Deficiencies:** SLCO1A2 influences the transport of vitamins and nucleosides, which are essential for various physiological processes. 4. **Neurological Disorders:** SLCO1A2 has been implicated in the transport of neurotransmitters, such as GABA, which is involved in neurological disorders, such as epilepsy and anxiety disorders. In conclusion, the SLCO1A2 gene plays a critical role in the transport of organic anions, including bile acids and steroids, across cell membranes. Variations in the SLCO1A2 gene have significant clinical implications, including the development of metabolic disorders, pharmacokinetic variability, and nutritional deficiencies. Further research is necessary to fully understand the mechanisms of SLCO1A2-mediated transport and its clinical significance.

Genular Protein ID: 1152922612

Symbol: SO1A2_HUMAN

Name: Solute carrier organic anion transporter family member 1A2

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 7557095

Title: Molecular and functional characterization of an organic anion transporting polypeptide cloned from human liver.

PubMed ID: 7557095

DOI: 10.1016/0016-5085(95)90588-x

PubMed ID: 10779507

Title: Localization and genomic organization of a new hepatocellular organic anion transporting polypeptide.

PubMed ID: 10779507

DOI: 10.1074/jbc.m001448200

PubMed ID: 11238933

Title: Antisense promoter of human L1 retrotransposon drives transcription of adjacent cellular genes.

PubMed ID: 11238933

DOI: 10.1128/mcb.21.6.1973-1985.2001

PubMed ID: 9539145

Title: Dehydroepiandrosterone sulfate (DHEAS): identification of a carrier protein in human liver and brain.

PubMed ID: 9539145

DOI: 10.1016/s0014-5793(98)00168-9

PubMed ID: 10873595

Title: Molecular identification and characterization of novel members of the human organic anion transporter (OATP) family.

PubMed ID: 10873595

DOI: 10.1006/bbrc.2000.2922

PubMed ID: 11159893

Title: Organic anion-transporting polypeptide B (OATP-B) and its functional comparison with three other OATPs of human liver.

PubMed ID: 11159893

DOI: 10.1053/gast.2001.21176

PubMed ID: 12409283

Title: Characterization and identification of steroid sulfate transporters of human placenta.

PubMed ID: 12409283

DOI: 10.1152/ajpendo.00257.2002

PubMed ID: 12568656

Title: Role of organic anion-transporting polypeptides, OATP-A, OATP-C and OATP-8, in the human placenta-maternal liver tandem excretory pathway for foetal bilirubin.

PubMed ID: 12568656

DOI: 10.1042/bj20030034

PubMed ID: 17301733

Title: Naringin is a major and selective clinical inhibitor of organic anion-transporting polypeptide 1A2 (OATP1A2) in grapefruit juice.

PubMed ID: 17301733

DOI: 10.1038/sj.clpt.6100104

PubMed ID: 19129463

Title: Mechanisms of pH-gradient driven transport mediated by organic anion polypeptide transporters.

PubMed ID: 19129463

DOI: 10.1152/ajpcell.00436.2008

PubMed ID: 20358049

Title: Transport of thyroid hormones is selectively inhibited by 3-iodothyronamine.

PubMed ID: 20358049

DOI: 10.1039/b926588k

PubMed ID: 20686826

Title: Intestinal absorption of HMG-CoA reductase inhibitor pravastatin mediated by organic anion transporting polypeptide.

PubMed ID: 20686826

DOI: 10.1007/s11095-010-0216-5

PubMed ID: 23918469

Title: Functional analysis of novel polymorphisms in the human SLCO1A2 gene that encodes the transporter OATP1A2.

PubMed ID: 23918469

DOI: 10.1208/s12248-013-9515-1

PubMed ID: 23243220

Title: Influence of human OATP1B1, OATP1B3, and OATP1A2 on the pharmacokinetics of methotrexate and paclitaxel in humanized transgenic mice.

PubMed ID: 23243220

DOI: 10.1158/1078-0432.ccr-12-2080

PubMed ID: 25560245

Title: Human organic anion transporting polypeptide 1A2 (OATP1A2) mediates cellular uptake of all-trans-retinol in human retinal pigmented epithelial cells.

PubMed ID: 25560245

DOI: 10.1111/bph.13060

PubMed ID: 25132355

Title: Differential cellular expression of organic anion transporting peptides OATP1A2 and OATP2B1 in the human retina and brain: implications for carrier-mediated transport of neuropeptides and neurosteriods in the CNS.

PubMed ID: 25132355

DOI: 10.1007/s00424-014-1596-x

PubMed ID: 27777271

Title: Contribution of Organic Anion-Transporting Polypeptides 1A/1B to Doxorubicin Uptake and Clearance.

PubMed ID: 27777271

DOI: 10.1124/mol.116.105544

PubMed ID: 35307651

Title: Localization of Xenobiotic Transporters Expressed at the Human Blood-Testis Barrier.

PubMed ID: 35307651

DOI: 10.1124/dmd.121.000748

PubMed ID: 15632119

Title: Polymorphisms in human organic anion-transporting polypeptide 1A2 (OATP1A2): implications for altered drug disposition and central nervous system drug entry.

PubMed ID: 15632119

DOI: 10.1074/jbc.m411092200

PubMed ID: 16959974

Title: The consensus coding sequences of human breast and colorectal cancers.

PubMed ID: 16959974

DOI: 10.1126/science.1133427

Sequence Information:

  • Length: 670
  • Mass: 74145
  • Checksum: C3A740CEF1E6F129
  • Sequence:
  • MGETEKRIET HRIRCLSKLK MFLLAITCAF VSKTLSGSYM NSMLTQIERQ FNIPTSLVGF 
    INGSFEIGNL LLIIFVSYFG TKLHRPIMIG IGCVVMGLGC FLKSLPHFLM NQYEYESTVS 
    VSGNLSSNSF LCMENGTQIL RPTQDPSECT KEVKSLMWVY VLVGNIVRGM GETPILPLGI 
    SYIEDFAKFE NSPLYIGLVE TGAIIGPLIG LLLASFCANV YVDTGFVNTD DLIITPTDTR 
    WVGAWWFGFL ICAGVNVLTA IPFFFLPNTL PKEGLETNAD IIKNENEDKQ KEEVKKEKYG 
    ITKDFLPFMK SLSCNPIYML FILVSVIQFN AFVNMISFMP KYLEQQYGIS SSDAIFLMGI 
    YNLPPICIGY IIGGLIMKKF KITVKQAAHI GCWLSLLEYL LYFLSFLMTC ENSSVVGINT 
    SYEGIPQDLY VENDIFADCN VDCNCPSKIW DPVCGNNGLS YLSACLAGCE TSIGTGINMV 
    FQNCSCIQTS GNSSAVLGLC DKGPDCSLML QYFLILSAMS SFIYSLAAIP GYMVLLRCMK 
    SEEKSLGVGL HTFCTRVFAG IPAPIYFGAL MDSTCLHWGT LKCGESGACR IYDSTTFRYI 
    YLGLPAALRG SSFVPALIIL ILLRKCHLPG ENASSGTELI ETKVKGKENE CKDIYQKSTV 
    LKDDELKTKL

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.