Details for: PPP2R2A
Gene ID: 5520
Gene Type: Protein-coding - A gene that serves as a template for producing a messenger RNA (mRNA) molecule, which is then translated into a functional protein.
Symbol: PPP2R2A
Ensembl ID: ENSG00000221914
Description: protein phosphatase 2 regulatory subunit Balpha
Selected Context(s): Overall
Cell Significance Landscape
Associated with
Significant Cells
Cell Significance Index (CSI) scores for the chosen context(s)
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CSI 45.16rCSI 68.98%PRS 18.62
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CSI 42.87rCSI 53.32%PRS 19.66
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CSI 27.71rCSI 67.35%PRS 10.72
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CSI 20.29rCSI 58.05%PRS 32.55
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CSI 17.95rCSI 72.43%PRS 16.68
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CSI 16.43rCSI 59.13%PRS 10.26
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CSI 16.09rCSI 50.27%PRS 11.64
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CSI 13.56rCSI 66.84%PRS 25.06
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CSI 13.02rCSI 28.82%PRS 17.14
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CSI 10.62rCSI 19.3%PRS 28.21
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CSI 10.21rCSI 23.35%PRS 17.98
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CSI 9.08rCSI 14.03%PRS 17.33
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CSI 8.97rCSI 52.82%PRS 11.44
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CSI 8.96rCSI 10.53%PRS 21.5
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CSI 8.27rCSI 38.88%PRS 19.83
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CSI 8.09rCSI 42.54%PRS 21.73
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CSI 7.44rCSI 16.39%PRS 28.15
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CSI 7.25rCSI 18.91%PRS 28.3
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CSI 6.64rCSI 57.18%PRS 8.66
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CSI 6.46rCSI 8.64%PRS 24.19
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CSI 6.45rCSI 18.08%PRS 28.64
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CSI 6.4rCSI 18.93%PRS 16.7
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CSI 6.33rCSI 13.14%PRS 18.45
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CSI 6.32rCSI 9.66%PRS 23.89
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CSI 5.63rCSI 16.72%PRS 26.05
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CSI 5.6rCSI 41.15%PRS 10.56
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CSI 5.38rCSI 11.79%PRS 24.77
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CSI 5.09rCSI 7.82%PRS 22.08
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CSI 5.06rCSI 10.97%PRS 12.3
-
CSI 4.86rCSI 52.9%PRS 35.24
-
CSI 4.72rCSI 12.73%PRS 23.97
-
CSI 4.72rCSI 4.81%PRS 26.54
-
CSI 4.62rCSI 3.7%PRS 33.05
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CSI 4.55rCSI 7.23%PRS 15.64
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CSI 4.49rCSI 7.09%PRS 18.61
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CSI 4.3rCSI 13.24%PRS 27.67
-
CSI 4.28rCSI 4.12%PRS 13.32
-
CSI 4.14rCSI 7.4%PRS 17.1
-
CSI 3.7rCSI 20.21%PRS 29.49
-
CSI 3.65rCSI 29.67%PRS 18.74
-
CSI 3.59rCSI 86%PRS 9.23
-
CSI 3.56rCSI 85.78%PRS 10.17
-
CSI 3.44rCSI 5.67%PRS 21.86
-
CSI 3.37rCSI 5.44%PRS 28.64
-
CSI 3.29rCSI 5.69%PRS 14.11
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CSI 3.16rCSI 11.96%PRS 11.22
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CSI 3.14rCSI 73.07%PRS 34.43
-
CSI 3.03rCSI 5.45%PRS 15.35
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CSI 3rCSI 4.45%PRS 22.16
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CSI 2.88rCSI 8.34%PRS 39.59
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CSI 2.78rCSI 2.25%PRS 29.13
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CSI 2.67rCSI 3.7%PRS 26.2
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CSI 2.47rCSI 3.61%PRS 21.36
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CSI 2.43rCSI 19.04%PRS 37.59
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CSI 2.41rCSI 1.92%PRS 32.8
-
CSI 2.34rCSI 9.1%PRS 25.09
-
CSI 2.3rCSI 3.38%PRS 16.98
-
CSI 2.21rCSI 11.34%PRS 18.66
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CSI 2.16rCSI 8.23%PRS 18.08
-
CSI 2.16rCSI 1.7%PRS 12.68
-
CSI 2.15rCSI 5.13%PRS 21.38
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CSI 2.15rCSI 16.13%PRS 18.57
-
CSI 2.14rCSI 3.06%PRS 25.23
-
CSI 2.1rCSI 3.22%PRS 25.5
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CSI 2.09rCSI 7.42%PRS 30.07
-
CSI 2.08rCSI 5.39%PRS 23.84
-
CSI 2.07rCSI 2.66%PRS 17.94
-
CSI 1.94rCSI 5.05%PRS 46.56
-
CSI 1.88rCSI 4.52%PRS 27.36
-
CSI 1.86rCSI 3.13%PRS 10.92
-
CSI 1.86rCSI 6.02%PRS 22.36
-
CSI 1.84rCSI 1.39%PRS 25.39
-
CSI 1.83rCSI 4.17%PRS 15.93
-
CSI 1.82rCSI 3.6%PRS 19.5
-
CSI 1.8rCSI 4.67%PRS 46.22
-
CSI 1.79rCSI 1.24%PRS 26.29
-
CSI 1.78rCSI 1.38%PRS 27.11
-
CSI 1.77rCSI 10.48%PRS 19.65
-
CSI 1.75rCSI 12.55%PRS 19.31
-
CSI 1.74rCSI 1.62%PRS 18.57
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CSI 1.73rCSI 3.23%PRS 13.3
-
CSI 1.71rCSI 2.2%PRS 17.93
-
CSI 1.71rCSI 3.02%PRS 10.88
-
CSI 1.63rCSI 1.51%PRS 33.28
-
CSI 1.61rCSI 7.73%PRS 22.75
-
CSI 1.6rCSI 1.67%PRS 18.97
-
CSI 1.59rCSI 4.19%PRS 35.8
-
CSI 1.58rCSI 3.02%PRS 29.32
-
CSI 1.56rCSI 1.9%PRS 23.27
-
CSI 1.53rCSI 2.21%PRS 29.25
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CSI 1.53rCSI 3.67%PRS 32.98
-
CSI 1.51rCSI 2.85%PRS 48.57
-
CSI 1.5rCSI 1.86%PRS 16.22
-
CSI 1.49rCSI 1.74%PRS 25.33
-
CSI 1.48rCSI 3.83%PRS 17.23
-
CSI 1.47rCSI 1.03%PRS 19.68
-
CSI 1.47rCSI 4.79%PRS 22.45
-
CSI 1.47rCSI 3.44%PRS 26.75
-
CSI 1.47rCSI 3.58%PRS 18.21
-
CSI 1.46rCSI 1.67%PRS 37.4
-
CSI -3.6rCSI -5.6%PRS 42.6%
-
CSI -1.9rCSI -4.8%PRS 18.7%
-
CSI -1.6rCSI -4.8%PRS 14.2%
-
CSI -0.8rCSI -0.7%PRS 21.3%
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CSI -0.4rCSI -0.7%PRS 25.1%
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CSI 0.0rCSI 0.0%PRS 27.4%
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CSI 0.0rCSI 0.1%PRS 33.0%
-
CSI 0.1rCSI 0.4%PRS 27.2%
-
CSI 0.1rCSI 0.1%PRS 20.3%
-
CSI 0.1rCSI 0.5%PRS 32.7%
-
CSI 0.1rCSI 0.3%PRS 24.3%
-
CSI 0.1rCSI 0.8%PRS 46.3%
-
CSI 0.1rCSI 1.4%PRS 24.4%
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CSI 0.1rCSI 0.6%PRS 16.1%
-
CSI 0.1rCSI 0.2%PRS 23.8%
-
CSI 0.2rCSI 0.6%PRS 25.7%
-
CSI 0.2rCSI 0.5%PRS 31.5%
-
CSI 0.2rCSI 0.9%PRS 19.9%
-
CSI 0.2rCSI 1.2%PRS 45.8%
-
CSI 0.2rCSI 1.5%PRS 33.7%
-
CSI 0.2rCSI 1.4%PRS 35.8%
-
CSI 0.2rCSI 0.8%PRS 30.4%
-
CSI 0.2rCSI 0.2%PRS 20.8%
-
CSI 0.2rCSI 0.9%PRS 32.4%
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CSI 0.2rCSI 1.2%PRS 49.0%
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CSI 0.2rCSI 1.4%PRS 14.4%
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CSI 0.2rCSI 3.5%PRS 44.5%
-
CSI 0.2rCSI 0.2%PRS 19.4%
-
CSI 0.2rCSI 4.8%PRS 15.7%
-
CSI 0.3rCSI 0.4%PRS 24.3%
-
CSI 0.3rCSI 1.2%PRS 37.1%
-
CSI 0.3rCSI 1.5%PRS 57.1%
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CSI 0.3rCSI 1.2%PRS 18.1%
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CSI 0.3rCSI 0.2%PRS 22.6%
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CSI 0.3rCSI 4.1%PRS 44.5%
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CSI 0.3rCSI 0.4%PRS 18.4%
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CSI 0.3rCSI 0.3%PRS 32.0%
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CSI 0.3rCSI 0.3%PRS 23.2%
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CSI 0.3rCSI 3.0%PRS 55.2%
-
CSI 0.3rCSI 0.6%PRS 18.9%
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CSI 0.3rCSI 0.8%PRS 17.0%
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CSI 0.3rCSI 0.3%PRS 21.6%
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CSI 0.3rCSI 0.5%PRS 16.4%
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CSI 0.4rCSI 1.2%PRS 16.0%
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CSI 0.4rCSI 0.8%PRS 36.1%
-
CSI 0.4rCSI 5.2%PRS 13.8%
-
CSI 0.4rCSI 1.0%PRS 29.7%
-
CSI 0.4rCSI 1.2%PRS 19.4%
-
CSI 0.4rCSI 0.6%PRS 21.2%
-
CSI 0.4rCSI 0.5%PRS 11.4%
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CSI 0.4rCSI 1.7%PRS 47.8%
-
CSI 0.4rCSI 0.3%PRS 18.5%
-
CSI 0.4rCSI 0.6%PRS 21.2%
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CSI 0.4rCSI 0.9%PRS 21.5%
-
CSI 0.4rCSI 2.1%PRS 35.9%
-
CSI 0.4rCSI 1.0%PRS 22.9%
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CSI 0.4rCSI 3.6%PRS 60.7%
-
CSI 0.4rCSI 0.6%PRS 27.8%
-
CSI 0.4rCSI 1.1%PRS 17.1%
-
CSI 0.4rCSI 0.7%PRS 14.2%
-
CSI 0.4rCSI 1.7%PRS 39.0%
-
CSI 0.4rCSI 2.3%PRS 32.9%
-
CSI 0.4rCSI 0.3%PRS 19.6%
-
CSI 0.4rCSI 0.5%PRS 10.7%
-
CSI 0.4rCSI 1.3%PRS 20.9%
-
CSI 0.4rCSI 0.6%PRS 19.6%
-
CSI 0.4rCSI 1.9%PRS 34.2%
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CSI 0.4rCSI 10.6%PRS 54.9%
-
CSI 0.5rCSI 0.6%PRS 26.4%
-
CSI 0.5rCSI 1.1%PRS 11.6%
-
CSI 0.5rCSI 0.7%PRS 14.3%
-
CSI 0.5rCSI 0.8%PRS 14.2%
-
CSI 0.5rCSI 2.5%PRS 31.8%
-
CSI 0.5rCSI 1.0%PRS 29.4%
-
CSI 0.5rCSI 2.0%PRS 18.9%
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CSI 0.5rCSI 1.2%PRS 14.0%
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CSI 0.5rCSI 1.3%PRS 15.4%
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CSI 0.5rCSI 1.1%PRS 13.3%
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CSI 0.5rCSI 1.0%PRS 31.0%
-
CSI 0.5rCSI 1.7%PRS 11.1%
-
CSI 0.5rCSI 0.7%PRS 25.7%
-
CSI 0.5rCSI 1.5%PRS 21.3%
-
CSI 0.5rCSI 4.2%PRS 20.0%
-
CSI 0.5rCSI 3.1%PRS 27.6%
-
CSI 0.5rCSI 0.8%PRS 17.2%
-
CSI 0.5rCSI 0.4%PRS 27.3%
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CSI 0.6rCSI 2.6%PRS 14.0%
-
CSI 0.6rCSI 1.3%PRS 37.0%
-
CSI 0.6rCSI 1.1%PRS 23.4%
-
CSI 0.6rCSI 1.5%PRS 30.4%
-
CSI 0.6rCSI 0.7%PRS 21.4%
-
CSI 0.6rCSI 0.6%PRS 20.9%
-
CSI 0.6rCSI 0.5%PRS 17.5%
-
CSI 0.6rCSI 4.0%PRS 20.9%
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CSI 0.6rCSI 0.9%PRS 15.9%
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CSI 0.6rCSI 1.1%PRS 39.0%
-
CSI 0.6rCSI 3.0%PRS 24.5%
-
CSI 0.6rCSI 3.4%PRS 23.9%
-
CSI 0.6rCSI 0.5%PRS 22.1%
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CSI 0.6rCSI 4.1%PRS 19.2%
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Network Configuration
Explore relationships of the current gene. Select an Interaction Source: 'ONTOLOGY' for shared pathways (GO/Reactome) or 'STRING' for protein-protein interactions. Further refine by selecting context genes and comparing Cell Significance Index (CSI) scores between baseline and target cell types and their specific contexts.
Legend:
- Query Gene
-
Node Color (Target Cell CSI, relative to current network):
- Very High
- High
- Medium
- Low
- Very Low
- CSI N/A
- Node Size: Proportional to Target Cell CSI magnitude
- STRING PPI Edge
- Shared Pathway Edge (ONTOLOGY)
Other Information
This section provides additional information about the gene, including a description generated by an AI language model and details about associated proteins.
Genular Protein ID: 3849113515
Symbol: 2ABA_HUMAN
Name: Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 1849734
Title: Structure of the 55-kDa regulatory subunit of protein phosphatase 2A: evidence for a neuronal-specific isoform.
PubMed ID: 1849734
DOI: 10.1021/bi00229a001
PubMed ID: 14702039
Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.
PubMed ID: 14702039
DOI: 10.1038/ng1285
PubMed ID: 16421571
Title: DNA sequence and analysis of human chromosome 8.
PubMed ID: 16421571
DOI: 10.1038/nature04406
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 17245430
Title: A specific PP2A regulatory subunit, B56gamma, mediates DNA damage-induced dephosphorylation of p53 at Thr55.
PubMed ID: 17245430
PubMed ID: 19413330
Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.
PubMed ID: 19413330
DOI: 10.1021/ac9004309
PubMed ID: 21269460
Title: Initial characterization of the human central proteome.
PubMed ID: 21269460
PubMed ID: 22223895
Title: Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features.
PubMed ID: 22223895
PubMed ID: 24275569
Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.
PubMed ID: 24275569
PubMed ID: 25816751
Title: HSF1 transcriptional activity is modulated by IER5 and PP2A/B55.
PubMed ID: 25816751
PubMed ID: 27588481
Title: FAM122A, a new endogenous inhibitor of protein phosphatase 2A.
PubMed ID: 27588481
PubMed ID: 28609714
Title: MFHAS1 suppresses TLR4 signaling pathway via induction of PP2A C subunit cytoplasm translocation and inhibition of c-Jun dephosphorylation at Thr239.
PubMed ID: 28609714
PubMed ID: 30611118
Title: Mitogenic Signals Stimulate the CREB Coactivator CRTC3 through PP2A Recruitment.
PubMed ID: 30611118
PubMed ID: 33108758
Title: CHK1 Inhibitor Blocks Phosphorylation of FAM122A and Promotes Replication Stress.
PubMed ID: 33108758
Sequence Information:
- Length: 447
- Mass: 51692
- Checksum: F4D407FF7ADA4ED6
- Sequence:
MAGAGGGNDI QWCFSQVKGA VDDDVAEADI ISTVEFNHSG ELLATGDKGG RVVIFQQEQE NKIQSHSRGE YNVYSTFQSH EPEFDYLKSL EIEEKINKIR WLPQKNAAQF LLSTNDKTIK LWKISERDKR PEGYNLKEED GRYRDPTTVT TLRVPVFRPM DLMVEASPRR IFANAHTYHI NSISINSDYE TYLSADDLRI NLWHLEITDR SFNIVDIKPA NMEELTEVIT AAEFHPNSCN TFVYSSSKGT IRLCDMRASA LCDRHSKLFE EPEDPSNRSF FSEIISSISD VKFSHSGRYM MTRDYLSVKI WDLNMENRPV ETYQVHEYLR SKLCSLYEND CIFDKFECCW NGSDSVVMTG SYNNFFRMFD RNTKRDITLE ASRENNKPRT VLKPRKVCAS GKRKKDEISV DSLDFNKKIL HTAWHPKENI IAVATTNNLY IFQDKVN