Details for: PPP2R2A

Gene ID: 5520

Symbol: PPP2R2A

Ensembl ID: ENSG00000221914

Description: protein phosphatase 2 regulatory subunit Balpha

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 465.6845
    Cell Significance Index: -72.4400
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 276.2934
    Cell Significance Index: -70.0800
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 166.3804
    Cell Significance Index: -68.5400
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 160.2973
    Cell Significance Index: -75.6800
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 153.3019
    Cell Significance Index: -62.2800
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 138.4760
    Cell Significance Index: -71.2300
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 113.1259
    Cell Significance Index: -75.9100
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 65.6198
    Cell Significance Index: -62.6500
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 59.5358
    Cell Significance Index: -73.4100
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 25.7610
    Cell Significance Index: -69.0100
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 21.6607
    Cell Significance Index: -66.5300
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 18.9848
    Cell Significance Index: -74.9200
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 17.0384
    Cell Significance Index: -37.2900
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 3.8179
    Cell Significance Index: 101.9500
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 2.2158
    Cell Significance Index: 439.7300
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 2.1632
    Cell Significance Index: 433.9300
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 2.1139
    Cell Significance Index: 93.5100
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 1.9881
    Cell Significance Index: 75.2900
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 1.8993
    Cell Significance Index: 53.0800
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 1.6963
    Cell Significance Index: 46.1700
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 1.4925
    Cell Significance Index: 83.7500
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 1.3675
    Cell Significance Index: 35.1500
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 1.2420
    Cell Significance Index: 135.1000
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 1.1618
    Cell Significance Index: 19.5700
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 1.1507
    Cell Significance Index: 24.9300
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.1495
    Cell Significance Index: 59.7200
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 1.0851
    Cell Significance Index: 133.4300
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.0820
    Cell Significance Index: 83.0300
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 1.0735
    Cell Significance Index: 193.5200
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 1.0543
    Cell Significance Index: 378.1500
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.9146
    Cell Significance Index: 54.9100
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.9096
    Cell Significance Index: 42.7500
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.8946
    Cell Significance Index: 25.7800
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.8278
    Cell Significance Index: 37.5200
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.7785
    Cell Significance Index: 40.5500
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.7703
    Cell Significance Index: 57.4100
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.7296
    Cell Significance Index: 398.4600
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.6977
    Cell Significance Index: 308.4600
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.6856
    Cell Significance Index: 9.8600
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: 0.6097
    Cell Significance Index: 11.9000
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.6038
    Cell Significance Index: 545.2000
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.5817
    Cell Significance Index: 79.8900
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.5517
    Cell Significance Index: 33.9100
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.4767
    Cell Significance Index: 329.7000
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.3321
    Cell Significance Index: 42.9100
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 0.3304
    Cell Significance Index: 9.4700
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.2916
    Cell Significance Index: 34.3900
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.2589
    Cell Significance Index: 117.5100
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 0.2484
    Cell Significance Index: 16.7000
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: 0.2201
    Cell Significance Index: 1.3300
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.1979
    Cell Significance Index: 125.6800
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.1840
    Cell Significance Index: 346.5100
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.1449
    Cell Significance Index: 10.2500
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.1421
    Cell Significance Index: 27.0500
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.1388
    Cell Significance Index: 6.4700
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.1264
    Cell Significance Index: 4.4400
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0838
    Cell Significance Index: 129.0400
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0717
    Cell Significance Index: 132.2700
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.0664
    Cell Significance Index: 6.5700
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0442
    Cell Significance Index: 60.1400
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 0.0109
    Cell Significance Index: 0.1000
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0238
    Cell Significance Index: -17.6600
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: -0.0289
    Cell Significance Index: -2.0000
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0303
    Cell Significance Index: -5.1800
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0311
    Cell Significance Index: -3.9900
  • Cell Name: luminal hormone-sensing cell of mammary gland (CL4033058)
    Fold Change: -0.0398
    Cell Significance Index: -0.2500
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0467
    Cell Significance Index: -34.2500
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0608
    Cell Significance Index: -37.9800
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0627
    Cell Significance Index: -47.4400
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: -0.0719
    Cell Significance Index: -11.7000
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.1025
    Cell Significance Index: -57.8300
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.1495
    Cell Significance Index: -9.6500
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.1840
    Cell Significance Index: -18.8000
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.2064
    Cell Significance Index: -43.4800
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.2237
    Cell Significance Index: -64.3700
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.2259
    Cell Significance Index: -32.8400
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.2719
    Cell Significance Index: -3.7100
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.3430
    Cell Significance Index: -11.9200
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.3481
    Cell Significance Index: -40.5700
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.3560
    Cell Significance Index: -37.0700
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.3600
    Cell Significance Index: -18.9000
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.3954
    Cell Significance Index: -45.1400
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.4100
    Cell Significance Index: -10.7800
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.4137
    Cell Significance Index: -8.8100
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.4361
    Cell Significance Index: -49.9600
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.5588
    Cell Significance Index: -35.2200
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.5766
    Cell Significance Index: -9.6500
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.6511
    Cell Significance Index: -18.5800
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.6641
    Cell Significance Index: -11.3800
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: -0.7087
    Cell Significance Index: -10.4600
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.7758
    Cell Significance Index: -61.4400
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.7947
    Cell Significance Index: -21.3000
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: -0.9324
    Cell Significance Index: -22.7500
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -1.0301
    Cell Significance Index: -25.7500
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: -1.0330
    Cell Significance Index: -18.2600
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -1.0608
    Cell Significance Index: -25.4400
  • Cell Name: basal epithelial cell of prostatic duct (CL0002236)
    Fold Change: -1.0956
    Cell Significance Index: -9.7300
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: -1.1036
    Cell Significance Index: -15.7100
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -1.1400
    Cell Significance Index: -13.5900
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: -1.1438
    Cell Significance Index: -7.7500

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Structural Homology:** PPP2R2A shares structural similarity with other PP2A regulatory subunits, suggesting a conserved functional mechanism across species. 2. **Protein Phosphatase Activity:** PPP2R2A is a component of the PP2A complex, which is a serine/threonine phosphatase responsible for dephosphorylating and regulating numerous protein substrates. 3. **Cellular Localization:** PPP2R2A is distributed across various cellular compartments, including the cytosol, nucleus, and mitochondria, indicating its involvement in multiple cellular processes. 4. **Regulatory Interactions:** PPP2R2A interacts with diverse protein partners, including cyclin-dependent kinases, phosphatidylinositol 3-kinase, and other PP2A regulatory subunits, to modulate signaling pathways and cellular behavior. **Pathways and Functions:** 1. **Cell Cycle Regulation:** PPP2R2A plays a critical role in regulating cell cycle progression, particularly during the G2/M transition and G1/S transition, by dephosphorylating and activating key cyclin-dependent kinases. 2. **Signal Transduction:** PPP2R2A modulates signal transduction pathways, including those involved in morphine response, glutamatergic synapse formation, and RNA metabolism. 3. **Gene Expression:** PPP2R2A influences gene expression by regulating the activity of transcription factors and other RNA-binding proteins. 4. **Mitotic Events:** PPP2R2A is involved in mitotic events, including metaphase and anaphase, by modulating the activity of mitotic kinases and other mitotic regulators. **Clinical Significance:** 1. **Cancer Research:** Alterations in PPP2R2A expression have been linked to various cancers, including breast, prostate, and lung cancer, suggesting its potential as a therapeutic target. 2. **Neurological Disorders:** PPP2R2A's involvement in neuronal function and synaptic plasticity makes it a promising candidate for the treatment of neurodegenerative diseases, such as Alzheimer's and Parkinson's. 3. **Metabolic Disorders:** PPP2R2A's role in regulating glucose and lipid metabolism makes it an attractive target for the treatment of metabolic disorders, such as diabetes and obesity. 4. **Neurodevelopmental Disorders:** PPP2R2A's expression in neural progenitor cells and its involvement in neural development suggest its potential as a therapeutic target for neurodevelopmental disorders, such as autism and schizophrenia. In conclusion, PPP2R2A is a multifunctional protein phosphatase subunit that plays a critical role in regulating various cellular processes, from cell cycle progression to gene expression. Its clinical significance is underscored by its involvement in cancer, neurological disorders, metabolic disorders, and neurodevelopmental disorders, highlighting its potential as a therapeutic target and a valuable tool for understanding cellular regulation.

Genular Protein ID: 3849113515

Symbol: 2ABA_HUMAN

Name: Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform

UniProtKB Accession Codes:

P63151 B2RBU8 B4E1T7 P50409 Q00007

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CORUM 1 CTD 1 ChEMBL 1 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 1 EMBL 6 EMDB 3 Ensembl 2 EvolutionaryTrace 1 ExpressionAtlas 1 GO 7 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 4 PDBsum 4 PIR 1 PIRSF 1 PRIDE 1 PRINTS 1 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 Reactome 4 RefSeq 2 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 1849734

Title: Structure of the 55-kDa regulatory subunit of protein phosphatase 2A: evidence for a neuronal-specific isoform.

PubMed ID: 1849734

DOI: 10.1021/bi00229a001

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16421571

Title: DNA sequence and analysis of human chromosome 8.

PubMed ID: 16421571

DOI: 10.1038/nature04406

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 17245430

Title: A specific PP2A regulatory subunit, B56gamma, mediates DNA damage-induced dephosphorylation of p53 at Thr55.

PubMed ID: 17245430

DOI: 10.1038/sj.emboj.7601519

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 22223895

Title: Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features.

PubMed ID: 22223895

DOI: 10.1074/mcp.m111.015131

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25816751

Title: HSF1 transcriptional activity is modulated by IER5 and PP2A/B55.

PubMed ID: 25816751

DOI: 10.1016/j.febslet.2015.03.019

PubMed ID: 27588481

Title: FAM122A, a new endogenous inhibitor of protein phosphatase 2A.

PubMed ID: 27588481

DOI: 10.18632/oncotarget.11698

PubMed ID: 28609714

Title: MFHAS1 suppresses TLR4 signaling pathway via induction of PP2A C subunit cytoplasm translocation and inhibition of c-Jun dephosphorylation at Thr239.

PubMed ID: 28609714

DOI: 10.1016/j.molimm.2017.06.017

PubMed ID: 30611118

Title: Mitogenic Signals Stimulate the CREB Coactivator CRTC3 through PP2A Recruitment.

PubMed ID: 30611118

DOI: 10.1016/j.isci.2018.12.012

PubMed ID: 33108758

Title: CHK1 Inhibitor Blocks Phosphorylation of FAM122A and Promotes Replication Stress.

PubMed ID: 33108758

DOI: 10.1016/j.molcel.2020.10.008

Sequence Information:

  • Length: 447
  • Mass: 51692
  • Checksum: F4D407FF7ADA4ED6
  • Sequence:
    • MAGAGGGNDI QWCFSQVKGA VDDDVAEADI ISTVEFNHSG ELLATGDKGG RVVIFQQEQE 
NKIQSHSRGE YNVYSTFQSH EPEFDYLKSL EIEEKINKIR WLPQKNAAQF LLSTNDKTIK 
LWKISERDKR PEGYNLKEED GRYRDPTTVT TLRVPVFRPM DLMVEASPRR IFANAHTYHI 
NSISINSDYE TYLSADDLRI NLWHLEITDR SFNIVDIKPA NMEELTEVIT AAEFHPNSCN 
TFVYSSSKGT IRLCDMRASA LCDRHSKLFE EPEDPSNRSF FSEIISSISD VKFSHSGRYM 
MTRDYLSVKI WDLNMENRPV ETYQVHEYLR SKLCSLYEND CIFDKFECCW NGSDSVVMTG 
SYNNFFRMFD RNTKRDITLE ASRENNKPRT VLKPRKVCAS GKRKKDEISV DSLDFNKKIL 
HTAWHPKENI IAVATTNNLY IFQDKVN

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.