DYNC1I2 | ENSG00000077380 | NCBI 1781

Details for: DYNC1I2

Gene ID: 1781

Symbol: DYNC1I2

Ensembl ID: ENSG00000077380

Description: dynein cytoplasmic 1 intermediate chain 2

Associated with

Adaptive immune system
(R-HSA-1280218)
Aggrephagy
(R-HSA-9646399)
Amplification of signal from the kinetochores
(R-HSA-141424)
Amplification of signal from unattached kinetochores via a mad2 inhibitory signal
(R-HSA-141444)
Anchoring of the basal body to the plasma membrane
(R-HSA-5620912)
Asparagine n-linked glycosylation
(R-HSA-446203)
Aurka activation by tpx2
(R-HSA-8854518)
Autophagy
(R-HSA-9612973)
Cell cycle
(R-HSA-1640170)
Cell cycle, mitotic
(R-HSA-69278)
Cell cycle checkpoints
(R-HSA-69620)
Cellular responses to stimuli
(R-HSA-8953897)
Cellular responses to stress
(R-HSA-2262752)
Centrosome maturation
(R-HSA-380287)
Cilium assembly
(R-HSA-5617833)
Copi-independent golgi-to-er retrograde traffic
(R-HSA-6811436)
Copi-mediated anterograde transport
(R-HSA-6807878)
Disease
(R-HSA-1643685)
Eml4 and nudc in mitotic spindle formation
(R-HSA-9648025)
Er to golgi anterograde transport
(R-HSA-199977)
G2/m transition
(R-HSA-69275)
Golgi-to-er retrograde transport
(R-HSA-8856688)
Hcmv early events
(R-HSA-9609690)
Hcmv infection
(R-HSA-9609646)
Hsp90 chaperone cycle for steroid hormone receptors (shr) in the presence of ligand
(R-HSA-3371497)
Immune system
(R-HSA-168256)
Infectious disease
(R-HSA-5663205)
Intra-golgi and retrograde golgi-to-er traffic
(R-HSA-6811442)
Loss of nlp from mitotic centrosomes
(R-HSA-380259)
Loss of proteins required for interphase microtubule organization from the centrosome
(R-HSA-380284)
Macroautophagy
(R-HSA-1632852)
Membrane trafficking
(R-HSA-199991)
Metabolism of proteins
(R-HSA-392499)
Mhc class ii antigen presentation
(R-HSA-2132295)
Mitotic anaphase
(R-HSA-68882)
Mitotic g2-g2/m phases
(R-HSA-453274)
Mitotic metaphase and anaphase
(R-HSA-2555396)
Mitotic prometaphase
(R-HSA-68877)
Mitotic spindle checkpoint
(R-HSA-69618)
M phase
(R-HSA-68886)
Organelle biogenesis and maintenance
(R-HSA-1852241)
Post-translational protein modification
(R-HSA-597592)
Recruitment of mitotic centrosome proteins and complexes
(R-HSA-380270)
Recruitment of numa to mitotic centrosomes
(R-HSA-380320)
Regulation of plk1 activity at g2/m transition
(R-HSA-2565942)
Resolution of sister chromatid cohesion
(R-HSA-2500257)
Rho gtpase effectors
(R-HSA-195258)
Rho gtpases activate formins
(R-HSA-5663220)
Selective autophagy
(R-HSA-9663891)
Separation of sister chromatids
(R-HSA-2467813)
Signaling by rho gtpases
(R-HSA-194315)
Signaling by rho gtpases, miro gtpases and rhobtb3
(R-HSA-9716542)
Signal transduction
(R-HSA-162582)
Transport to the golgi and subsequent modification
(R-HSA-948021)
Vesicle-mediated transport
(R-HSA-5653656)
Viral infection pathways
(R-HSA-9824446)
Centrosome
(GO:0005813)
Cytoplasm
(GO:0005737)
Cytoplasmic dynein complex
(GO:0005868)
Cytosol
(GO:0005829)
Dynein complex
(GO:0030286)
Dynein heavy chain binding
(GO:0045504)
Dynein light chain binding
(GO:0045503)
Microtubule
(GO:0005874)
Microtubule-based movement
(GO:0007018)
Microtubule motor activity
(GO:0003777)
Protein binding
(GO:0005515)
Transport along microtubule
(GO:0010970)
Vesicle
(GO:0031982)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: polychromatophilic erythroblast (CL0000550)
Fold Change: 540.6466
Cell Significance Index: -84.1000
Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
Fold Change: 350.2950
Cell Significance Index: -88.8500
Cell Name: embryonic stem cell (CL0002322)
Fold Change: 227.8445
Cell Significance Index: -93.8600
Cell Name: smooth muscle fiber of ileum (CL1000278)
Fold Change: 208.3992
Cell Significance Index: -98.3900
Cell Name: mucosal type mast cell (CL0000485)
Fold Change: 195.2950
Cell Significance Index: -79.3400
Cell Name: peripheral blood mononuclear cell (CL2000001)
Fold Change: 178.7765
Cell Significance Index: -91.9600
Cell Name: ciliated cell of the bronchus (CL0002332)
Fold Change: 83.5094
Cell Significance Index: -79.7300
Cell Name: orthochromatic erythroblast (CL0000552)
Fold Change: 75.6678
Cell Significance Index: -93.3000
Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
Fold Change: 34.1638
Cell Significance Index: -91.5200
Cell Name: stromal cell of bone marrow (CL0010001)
Fold Change: 24.1533
Cell Significance Index: -95.3100
Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
Fold Change: 23.9007
Cell Significance Index: -73.4100
Cell Name: epidermal Langerhans cell (CL0002457)
Fold Change: 13.8857
Cell Significance Index: -30.3900
Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: 2.3614
Cell Significance Index: 473.7000
Cell Name: basal cell of urothelium (CL1000486)
Fold Change: 2.3410
Cell Significance Index: 287.8500
Cell Name: intermediate cell of urothelium (CL4030055)
Fold Change: 2.2764
Cell Significance Index: 410.3700
Cell Name: neoplastic cell (CL0001063)
Fold Change: 2.1962
Cell Significance Index: 435.8500
Cell Name: odontoblast (CL0000060)
Fold Change: 1.9758
Cell Significance Index: 253.2800
Cell Name: stromal cell of ovary (CL0002132)
Fold Change: 1.7772
Cell Significance Index: 244.0600
Cell Name: lung endothelial cell (CL1001567)
Fold Change: 1.6913
Cell Significance Index: 88.1000
Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 1.4216
Cell Significance Index: 40.9600
Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: 1.4202
Cell Significance Index: 509.4200
Cell Name: fibroblast of dermis (CL0002551)
Fold Change: 1.3033
Cell Significance Index: 27.2800
Cell Name: GABAergic interneuron (CL0011005)
Fold Change: 1.2709
Cell Significance Index: 879.0300
Cell Name: retinal progenitor cell (CL0002672)
Fold Change: 1.1389
Cell Significance Index: 63.9100
Cell Name: cell in vitro (CL0001034)
Fold Change: 1.0060
Cell Significance Index: 549.3800
Cell Name: hair follicular keratinocyte (CL2000092)
Fold Change: 0.9915
Cell Significance Index: 438.3600
Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: 0.7618
Cell Significance Index: 34.5300
Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
Fold Change: 0.7096
Cell Significance Index: 33.3500
Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 0.6579
Cell Significance Index: 71.5600
Cell Name: bladder urothelial cell (CL1001428)
Fold Change: 0.6457
Cell Significance Index: 33.5400
Cell Name: fibro/adipogenic progenitor cell (CL0009099)
Fold Change: 0.6140
Cell Significance Index: 31.0300
Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: 0.6018
Cell Significance Index: 28.0600
Cell Name: basal cell of prostate epithelium (CL0002341)
Fold Change: 0.5812
Cell Significance Index: 15.8200
Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: 0.5687
Cell Significance Index: 42.3900
Cell Name: eye photoreceptor cell (CL0000287)
Fold Change: 0.5449
Cell Significance Index: 34.3500
Cell Name: tuft cell of colon (CL0009041)
Fold Change: 0.4173
Cell Significance Index: 376.7900
Cell Name: umbrella cell of urothelium (CL4030056)
Fold Change: 0.4029
Cell Significance Index: 3.7100
Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
Fold Change: 0.3983
Cell Significance Index: 13.8400
Cell Name: glycinergic neuron (CL1001509)
Fold Change: 0.3661
Cell Significance Index: 19.2200
Cell Name: small intestine goblet cell (CL1000495)
Fold Change: 0.3204
Cell Significance Index: 11.2600
Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: 0.3056
Cell Significance Index: 58.1500
Cell Name: lactocyte (CL0002325)
Fold Change: 0.2970
Cell Significance Index: 38.3700
Cell Name: microfold cell of epithelium of small intestine (CL1000353)
Fold Change: 0.2646
Cell Significance Index: 18.3000
Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: 0.2125
Cell Significance Index: 36.2900
Cell Name: indirect pathway medium spiny neuron (CL4023029)
Fold Change: 0.1714
Cell Significance Index: 7.5800
Cell Name: sebum secreting cell (CL0000317)
Fold Change: 0.1342
Cell Significance Index: 9.4900
Cell Name: colon goblet cell (CL0009039)
Fold Change: 0.1218
Cell Significance Index: 12.0500
Cell Name: direct pathway medium spiny neuron (CL4023026)
Fold Change: 0.1165
Cell Significance Index: 4.4100
Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: 0.0887
Cell Significance Index: 166.9700
Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: 0.0818
Cell Significance Index: 6.2800
Cell Name: placental villous trophoblast (CL2000060)
Fold Change: 0.0382
Cell Significance Index: 1.0200
Cell Name: anterior lens cell (CL0002223)
Fold Change: 0.0318
Cell Significance Index: 58.5600
Cell Name: lens epithelial cell (CL0002224)
Fold Change: 0.0315
Cell Significance Index: 48.4500
Cell Name: secondary lens fiber (CL0002225)
Fold Change: -0.0060
Cell Significance Index: -8.1700
Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
Fold Change: -0.0078
Cell Significance Index: -5.7100
Cell Name: ciliary muscle cell (CL1000443)
Fold Change: -0.0128
Cell Significance Index: -5.8000
Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: -0.0147
Cell Significance Index: -9.3500
Cell Name: mesenchymal cell (CL0008019)
Fold Change: -0.0418
Cell Significance Index: -0.7000
Cell Name: pulmonary alveolar epithelial cell (CL0000322)
Fold Change: -0.0421
Cell Significance Index: -31.8800
Cell Name: pancreatic A cell (CL0000171)
Fold Change: -0.0516
Cell Significance Index: -38.2100
Cell Name: endothelial cell of venule (CL1000414)
Fold Change: -0.0634
Cell Significance Index: -0.7200
Cell Name: pancreatic PP cell (CL0002275)
Fold Change: -0.0882
Cell Significance Index: -55.0600
Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: -0.1122
Cell Significance Index: -18.2600
Cell Name: type B pancreatic cell (CL0000169)
Fold Change: -0.1169
Cell Significance Index: -65.9000
Cell Name: abnormal cell (CL0001061)
Fold Change: -0.1953
Cell Significance Index: -19.9500
Cell Name: preadipocyte (CL0002334)
Fold Change: -0.2014
Cell Significance Index: -3.9300
Cell Name: cerebellar granule cell (CL0001031)
Fold Change: -0.2077
Cell Significance Index: -3.5600
Cell Name: pancreatic D cell (CL0000173)
Fold Change: -0.2334
Cell Significance Index: -49.1700
Cell Name: dopaminergic neuron (CL0000700)
Fold Change: -0.2846
Cell Significance Index: -81.9000
Cell Name: pancreatic endocrine cell (CL0008024)
Fold Change: -0.3082
Cell Significance Index: -35.1800
Cell Name: early pro-B cell (CL0002046)
Fold Change: -0.3239
Cell Significance Index: -20.9000
Cell Name: tonsil germinal center B cell (CL2000006)
Fold Change: -0.3458
Cell Significance Index: -40.7800
Cell Name: granulosa cell (CL0000501)
Fold Change: -0.3503
Cell Significance Index: -9.2100
Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: -0.3929
Cell Significance Index: -57.1100
Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: -0.4435
Cell Significance Index: -50.8100
Cell Name: epithelial cell of stomach (CL0002178)
Fold Change: -0.4503
Cell Significance Index: -52.4800
Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
Fold Change: -0.4820
Cell Significance Index: -13.4700
Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: -0.6475
Cell Significance Index: -20.7400
Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: -0.7203
Cell Significance Index: -75.0000
Cell Name: Purkinje cell (CL0000121)
Fold Change: -0.7444
Cell Significance Index: -16.3000
Cell Name: skeletal muscle fiber (CL0008002)
Fold Change: -0.7929
Cell Significance Index: -20.3800
Cell Name: paneth cell of epithelium of small intestine (CL1000343)
Fold Change: -0.8041
Cell Significance Index: -17.4200
Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
Fold Change: -0.8345
Cell Significance Index: -66.1000
Cell Name: kidney cell (CL1000497)
Fold Change: -0.9243
Cell Significance Index: -7.3800
Cell Name: conjunctival epithelial cell (CL1000432)
Fold Change: -1.0290
Cell Significance Index: -14.0400
Cell Name: fibroblast of mammary gland (CL0002555)
Fold Change: -1.1362
Cell Significance Index: -32.5700
Cell Name: retinal rod cell (CL0000604)
Fold Change: -1.1493
Cell Significance Index: -13.7000
Cell Name: kidney epithelial cell (CL0002518)
Fold Change: -1.3146
Cell Significance Index: -38.7200
Cell Name: midget ganglion cell of retina (CL4023188)
Fold Change: -1.3190
Cell Significance Index: -13.7400
Cell Name: intestinal tuft cell (CL0019032)
Fold Change: -1.3938
Cell Significance Index: -85.4600
Cell Name: L6b glutamatergic cortical neuron (CL4023038)
Fold Change: -1.4142
Cell Significance Index: -46.3000
Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
Fold Change: -1.4470
Cell Significance Index: -46.0900
Cell Name: pro-T cell (CL0000827)
Fold Change: -1.5274
Cell Significance Index: -39.0200
Cell Name: gut absorptive cell (CL0000677)
Fold Change: -1.5370
Cell Significance Index: -92.2800
Cell Name: neuron associated cell (CL0000095)
Fold Change: -1.6061
Cell Significance Index: -65.8100
Cell Name: sst GABAergic cortical interneuron (CL4023017)
Fold Change: -1.6396
Cell Significance Index: -32.4200
Cell Name: skeletal muscle myoblast (CL0000515)
Fold Change: -1.6521
Cell Significance Index: -17.9600
Cell Name: peg cell (CL4033014)
Fold Change: -1.6954
Cell Significance Index: -39.1700
Cell Name: GABAergic amacrine cell (CL4030027)
Fold Change: -1.7572
Cell Significance Index: -21.8000
Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
Fold Change: -1.7998
Cell Significance Index: -63.0500

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

**Key Characteristics** 1. **Motor protein**: DYNC1I2 is a motor protein that utilizes ATP hydrolysis to generate force and move along microtubules, facilitating transport of vesicles, organelles, and proteins within the cell. 2. **Intermediate chain**: DYNC1I2 is an intermediate chain of the cytoplasmic dynein complex, linking the heavy chain to the light chain and enabling the complex to interact with microtubules. 3. **Highly expressed in neurons**: DYNC1I2 is significantly expressed in neurons, particularly in GABAergic neurons, Purkinje cells, and radial glial cells, highlighting its role in neuronal function and development. 4. **Diverse cellular expression**: DYNC1I2 is also expressed in other cell types, including mesenchymal stem cells, epithelial cells, and supporting cells, indicating its importance in various cellular processes. **Pathways and Functions** 1. **Cell cycle regulation**: DYNC1I2 plays a crucial role in regulating the cell cycle, particularly during mitosis, by facilitating the separation of sister chromatids and the resolution of chromosomal cohesion. 2. **Autophagy**: DYNC1I2 is involved in autophagy, a process by which cells recycle damaged or dysfunctional components, such as proteins and organelles. 3. **Microtubule organization**: DYNC1I2 helps maintain microtubule organization and dynamics, ensuring proper transport and movement within the cell. 4. **Cilium assembly**: DYNC1I2 is involved in the assembly and maintenance of cilia, specialized organelles involved in sensing and responding to environmental cues. 5. **Signaling pathways**: DYNC1I2 interacts with various signaling proteins, including Rho GTPases, to regulate cellular responses to stimuli and stress. **Clinical Significance** 1. **Neurodegenerative diseases**: Mutations in DYNC1I2 have been associated with neurodegenerative diseases, such as spinocerebellar ataxia type 10, highlighting its importance in neuronal function and development. 2. **Cancer**: Aberrant expression of DYNC1I2 has been observed in various types of cancer, suggesting its role in tumorigenesis and cancer progression. 3. **Autophagy-related disorders**: DYNC1I2 mutations have been linked to autophagy-related disorders, such as Ataxia-Telangiectasia, emphasizing the importance of autophagy in maintaining cellular homeostasis. 4. **Therapeutic targeting**: DYNC1I2 may serve as a target for therapeutic interventions in various diseases, including neurodegenerative disorders and cancer, highlighting the need for further research into its role in disease pathogenesis. In conclusion, DYNC1I2 is a crucial component of the cytoplasmic dynein complex, playing a vital role in various cellular processes, including cell cycle regulation, autophagy, and microtubule organization. Its highly specific expression in neurons and other cell types highlights its importance in maintaining cellular homeostasis and function, and its dysregulation has been implicated in various diseases, including neurodegenerative disorders and cancer.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

Cytoplasmic dynein 1 intermediate chain 2
B4DPZ3_HUMAN

Genular Protein ID: 2520474322

Symbol: DC1I2_HUMAN

Name: Cytoplasmic dynein 1 intermediate chain 2

UniProtKB Accession Codes:

Q13409 B7ZA04 D3DPD4 D3DPD5 D3DPD6 Q32LY9 Q53S84 Q5BJF8 Q7Z4X1 Q96NG7 Q96S87 Q9BXZ5 Q9NT58

Database IDs:

Citations:

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 17974005

Title: The full-ORF clone resource of the German cDNA consortium.

PubMed ID: 17974005

DOI: 10.1186/1471-2164-8-399

PubMed ID: 15815621

Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.

PubMed ID: 15815621

DOI: 10.1038/nature03466

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8522607

Title: Cytoplasmic dynein binds dynactin through a direct interaction between the intermediate chains and p150Glued.

PubMed ID: 8522607

DOI: 10.1083/jcb.131.6.1507

PubMed ID: 14654843

Title: Proteomic characterization of the human centrosome by protein correlation profiling.

PubMed ID: 14654843

DOI: 10.1038/nature02166

PubMed ID: 16964243

Title: A probability-based approach for high-throughput protein phosphorylation analysis and site localization.

PubMed ID: 16964243

DOI: 10.1038/nbt1240

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 20006841

Title: Adenovirus transport via direct interaction of cytoplasmic dynein with the viral capsid hexon subunit.

PubMed ID: 20006841

DOI: 10.1016/j.chom.2009.11.006

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 31079899

Title: Bi-allelic variants in DYNC1I2 cause syndromic microcephaly with intellectual disability, cerebral malformations, and dysmorphic facial features.

PubMed ID: 31079899

DOI: 10.1016/j.ajhg.2019.04.002

PubMed ID: 27502274

Title: Molecular basis for the protein recognition specificity of the dynein light chain DYNLT1/Tctex1: characterization of the interaction with activin receptor IIB.

PubMed ID: 27502274

DOI: 10.1074/jbc.m116.736884

PubMed ID: 29420470

Title: Cryo-EM shows how dynactin recruits two dyneins for faster movement.

PubMed ID: 29420470

DOI: 10.1038/nature25462

PubMed ID: 36071160

Title: Structure of dynein-dynactin on microtubules shows tandem adaptor binding.

PubMed ID: 36071160

DOI: 10.1038/s41586-022-05186-y

Sequence Information:

Length: 638
Mass: 71457
Checksum: 2F868EC9556C47F2
Sequence:

MSDKSELKAE LERKKQRLAQ IREEKKRKEE ERKKKETDQK KEAVAPVQEE SDLEKKRREA 
EALLQSMGLT PESPIVFSEY WVPPPMSPSS KSVSTPSEAG SQDSGDGAVG SRTLHWDTDP 
SVLQLHSDSD LGRGPIKLGM AKITQVDFPP REIVTYTKET QTPVMAQPKE DEEEDDDVVA 
PKPPIEPEEE KTLKKDEEND SKAPPHELTE EEKQQILHSE EFLSFFDHST RIVERALSEQ 
INIFFDYSGR DLEDKEGEIQ AGAKLSLNRQ FFDERWSKHR VVSCLDWSSQ YPELLVASYN 
NNEDAPHEPD GVALVWNMKY KKTTPEYVFH CQSAVMSATF AKFHPNLVVG GTYSGQIVLW 
DNRSNKRTPV QRTPLSAAAH THPVYCVNVV GTQNAHNLIS ISTDGKICSW SLDMLSHPQD 
SMELVHKQSK AVAVTSMSFP VGDVNNFVVG SEEGSVYTAC RHGSKAGISE MFEGHQGPIT 
GIHCHAAVGA VDFSHLFVTS SFDWTVKLWT TKNNKPLYSF EDNADYVYDV MWSPTHPALF 
ACVDGMGRLD LWNLNNDTEV PTASISVEGN PALNRVRWTH SGREIAVGDS EGQIVIYDVG 
EQIAVPRNDE WARFGRTLAE INANRADAEE EAATRIPA

Genular Protein ID: 4172738237

Symbol: B4DPZ3_HUMAN

Name: N/A

UniProtKB Accession Codes:

B4DPZ3

Database IDs:

Sequence Information:

Length: 630
Mass: 70457
Checksum: 38A4731D9AFAC592
Sequence:

MSDKSELKAE LERKKQRLAQ IREEKKRKEE ERKKKETDQK KEAVAPVQEE SDLEKKRREA 
EALLQSMGLT PESPIAEQPL RVVTADTCLF HYLVPPPMSP SSKSVSTPSE AGSQDSGDGA 
VGSRRGPIKL GMAKITQVDF PPREIVTYTK ETQTPVMAQP KEDEEEDDDA VAPKPPIEPE 
EEKTLKKDEE NDSKAPPHEL TEEEKQQILH SEEFLSFFDH STRIVERALS EQINIFFDYS 
GRDLEDKEGE IQAGAKLSLN RQFFDERWSK HRVVSCLDWS SQYPELLVAS YNNNEDAPHE 
PDGVALVWNM KYKKTTPEYV FHCQSAVMSA TFAKFHPNLV VGGTYSGQIV LWDNRSNKRT 
PVQRTPLSAA AHTHPVYCVN VVGTQNAHNL ISISTDGKIC SWSLDMLSHP QDSMELVHKQ 
SKAVAVTSMS FPVGDVNNFV VGSEEGSVYT ACRHGSKAGI SEMFEGHQGP ITGIHCHAAV 
GAVDFSHLFV TSSFDWTVKL WTTKNNKPLY SFEDNADYVY DVMWSPTHPA LFACVDGMGR 
LDLWNLNNDT EVPTASISVE GNPALNRVRW THSGREIAVG DSEGQIVIYD VGEQIAVPRN 
DEWARFGRTL AEINANRADA EEEAATRIPA

Database document:

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Details for: DYNC1I2

Associated with

Cells (max top 100)

Other Information

Complete sequencing and characterization of 21,243 full-length human cDNAs. PubMed ID: 14702039

The full-ORF clone resource of the German cDNA consortium. PubMed ID: 17974005

Generation and annotation of the DNA sequences of human chromosomes 2 and 4. PubMed ID: 15815621

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Cytoplasmic dynein binds dynactin through a direct interaction between the intermediate chains and p150Glued. PubMed ID: 8522607

Proteomic characterization of the human centrosome by protein correlation profiling. PubMed ID: 14654843

A probability-based approach for high-throughput protein phosphorylation analysis and site localization. PubMed ID: 16964243

A quantitative atlas of mitotic phosphorylation. PubMed ID: 18669648

Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach. PubMed ID: 19413330

Adenovirus transport via direct interaction of cytoplasmic dynein with the viral capsid hexon subunit. PubMed ID: 20006841

Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions. PubMed ID: 19690332

Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. PubMed ID: 20068231

Initial characterization of the human central proteome. PubMed ID: 21269460

System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. PubMed ID: 21406692

N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB. PubMed ID: 22814378

Toward a comprehensive characterization of a human cancer cell phosphoproteome. PubMed ID: 23186163

An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. PubMed ID: 24275569

N-terminome analysis of the human mitochondrial proteome. PubMed ID: 25944712

Bi-allelic variants in DYNC1I2 cause syndromic microcephaly with intellectual disability, cerebral malformations, and dysmorphic facial features. PubMed ID: 31079899

Molecular basis for the protein recognition specificity of the dynein light chain DYNLT1/Tctex1: characterization of the interaction with activin receptor IIB. PubMed ID: 27502274

Cryo-EM shows how dynactin recruits two dyneins for faster movement. PubMed ID: 29420470

Structure of dynein-dynactin on microtubules shows tandem adaptor binding. PubMed ID: 36071160