Details for: MARK3

Gene ID: 4140

Symbol: MARK3

Ensembl ID: ENSG00000075413

Description: microtubule affinity regulating kinase 3

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 477.2888
    Cell Significance Index: -74.2400
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 315.9948
    Cell Significance Index: -80.1500
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 182.6220
    Cell Significance Index: -86.2200
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 173.8554
    Cell Significance Index: -70.6300
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 156.1670
    Cell Significance Index: -80.3300
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 74.2504
    Cell Significance Index: -70.8900
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 65.1037
    Cell Significance Index: -80.2700
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 29.6432
    Cell Significance Index: -79.4100
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 27.1012
    Cell Significance Index: -83.2400
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 21.5912
    Cell Significance Index: -85.2000
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 21.1049
    Cell Significance Index: -46.1900
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 4.0763
    Cell Significance Index: 312.8100
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 2.7880
    Cell Significance Index: 1000.0000
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 2.6020
    Cell Significance Index: 521.9600
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 2.4465
    Cell Significance Index: 68.3700
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 2.3566
    Cell Significance Index: 29.2300
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 2.1934
    Cell Significance Index: 1517.0600
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 2.1475
    Cell Significance Index: 29.3000
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 2.0296
    Cell Significance Index: 402.7900
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: 1.9770
    Cell Significance Index: 38.5900
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 1.9522
    Cell Significance Index: 109.5500
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 1.7918
    Cell Significance Index: 291.4300
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 1.6915
    Cell Significance Index: 103.9700
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 1.4209
    Cell Significance Index: 24.3500
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 1.3815
    Cell Significance Index: 61.1100
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 1.3083
    Cell Significance Index: 33.6300
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 1.2604
    Cell Significance Index: 47.7300
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 1.1719
    Cell Significance Index: 78.8000
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: 1.0005
    Cell Significance Index: 24.0000
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.8526
    Cell Significance Index: 24.5700
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.7285
    Cell Significance Index: 79.2400
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.7262
    Cell Significance Index: 130.9200
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.7252
    Cell Significance Index: 89.1800
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.6821
    Cell Significance Index: 93.6700
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.5664
    Cell Significance Index: 1066.5400
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.4919
    Cell Significance Index: 444.1200
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.4333
    Cell Significance Index: 236.6400
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.3918
    Cell Significance Index: 23.5200
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.3632
    Cell Significance Index: 230.6800
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.3456
    Cell Significance Index: 4.9700
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.3206
    Cell Significance Index: 145.5200
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.2722
    Cell Significance Index: 502.0300
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.2598
    Cell Significance Index: 400.0200
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.2447
    Cell Significance Index: 11.0900
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.2342
    Cell Significance Index: 103.5300
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.1978
    Cell Significance Index: 4.2900
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.1808
    Cell Significance Index: 12.5000
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.1795
    Cell Significance Index: 244.0800
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.1586
    Cell Significance Index: 27.0800
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: 0.1307
    Cell Significance Index: 3.7300
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.1072
    Cell Significance Index: 5.5700
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.0601
    Cell Significance Index: 11.4400
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.0091
    Cell Significance Index: 0.4300
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.0090
    Cell Significance Index: 0.2400
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.0086
    Cell Significance Index: 0.4500
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0134
    Cell Significance Index: -0.4700
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: -0.0480
    Cell Significance Index: -0.6900
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0492
    Cell Significance Index: -6.3500
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0493
    Cell Significance Index: -36.5400
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0621
    Cell Significance Index: -45.5000
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0663
    Cell Significance Index: -50.2000
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0768
    Cell Significance Index: -47.9900
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.0959
    Cell Significance Index: -6.1800
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.1133
    Cell Significance Index: -63.9100
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.1584
    Cell Significance Index: -18.6800
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -0.1710
    Cell Significance Index: -3.6500
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.1717
    Cell Significance Index: -22.0200
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.1887
    Cell Significance Index: -14.0700
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.2056
    Cell Significance Index: -3.0400
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.2068
    Cell Significance Index: -10.8600
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: -0.2085
    Cell Significance Index: -20.6300
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.2284
    Cell Significance Index: -10.6500
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.2328
    Cell Significance Index: -23.7800
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.2441
    Cell Significance Index: -2.9100
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.2518
    Cell Significance Index: -36.6100
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.2615
    Cell Significance Index: -75.2300
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.2648
    Cell Significance Index: -55.7800
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: -0.2657
    Cell Significance Index: -1.8000
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.3578
    Cell Significance Index: -9.7400
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.3622
    Cell Significance Index: -7.9300
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.3625
    Cell Significance Index: -37.7400
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.5120
    Cell Significance Index: -59.6700
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.5196
    Cell Significance Index: -59.5300
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.5425
    Cell Significance Index: -34.1900
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.5759
    Cell Significance Index: -65.7400
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.5880
    Cell Significance Index: -15.7600
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.6935
    Cell Significance Index: -49.0500
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.7062
    Cell Significance Index: -24.5400
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.7427
    Cell Significance Index: -12.4300
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.9245
    Cell Significance Index: -73.2200
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.9247
    Cell Significance Index: -24.3200
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -1.0260
    Cell Significance Index: -29.4100
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -1.0817
    Cell Significance Index: -27.0400
  • Cell Name: OFF midget ganglion cell (CL4033047)
    Fold Change: -1.1075
    Cell Significance Index: -13.8100
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -1.1269
    Cell Significance Index: -69.0900
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: -1.1357
    Cell Significance Index: -27.7100
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -1.1391
    Cell Significance Index: -24.2600
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: -1.2128
    Cell Significance Index: -20.4300
  • Cell Name: hippocampal astrocyte (CL0002604)
    Fold Change: -1.3251
    Cell Significance Index: -18.5300
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: -1.3950
    Cell Significance Index: -20.5900

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** MARK3 is a member of the MAPK family, which is characterized by their ability to phosphorylate and regulate the activity of downstream targets. MARK3 is specifically known for its microtubule affinity, which allows it to interact with microtubules and regulate their dynamics. This property enables MARK3 to modulate the activity of various downstream targets, including proteins involved in cell signaling, cytoskeletal organization, and protein localization. MARK3 exhibits a unique kinase activity profile, with a preference for phosphorylating serine and threonine residues. This specificity is thought to be mediated by its microtubule-binding domain, which allows MARK3 to interact with microtubules and position its kinase domain for optimal substrate recognition. **Pathways and Functions** MARK3 is involved in multiple signaling pathways, including: 1. **MAPK signaling cascades**: MARK3 is a key regulator of the MAPK signaling pathway, which is involved in various cellular processes, including cell proliferation, differentiation, and survival. 2. **Tau-protein kinase activity**: MARK3 phosphorylates tau protein, a microtubule-associated protein that plays a crucial role in neuronal function and pathology. 3. **Protein localization to nucleus**: MARK3 regulates the localization of proteins to the nucleus, which is essential for various cellular processes, including transcriptional regulation and cell cycle progression. 4. **Negative regulation of Hippo signaling**: MARK3 negatively regulates the Hippo signaling pathway, which is involved in the regulation of cell growth and proliferation. 5. **Negative regulation of MAPK pathway**: MARK3 also negatively regulates the MAPK pathway, which is involved in various cellular processes, including cell proliferation, differentiation, and survival. **Clinical Significance** MARK3 has been implicated in various diseases, including: 1. **Neurodegenerative disorders**: MARK3 has been shown to be involved in the regulation of tau protein and its aggregation, which is thought to contribute to the pathogenesis of neurodegenerative disorders, such as Alzheimer's disease and frontotemporal dementia. 2. **Cancer**: MARK3 has been shown to be overexpressed in various types of cancer, including breast cancer and ovarian cancer, and is thought to contribute to tumor progression and metastasis. 3. **Cardiovascular disease**: MARK3 has been shown to be involved in the regulation of cardiac function and is thought to contribute to the pathogenesis of cardiovascular disease. In conclusion, MARK3 is a multifunctional kinase gene that plays a critical role in various cellular processes, including signal transduction, protein localization, and cell cycle regulation. Its involvement in disease pathogenesis highlights the importance of MARK3 as a potential therapeutic target for the treatment of various diseases.

Genular Protein ID: 3660778246

Symbol: MARK3_HUMAN

Name: MAP/microtubule affinity-regulating kinase 3

UniProtKB Accession Codes:

P27448 A0A0A0MQR8 A0A0A0MST9 A0A0A0MT23 O60219 Q86TT8 Q8TB41 Q8WX83 Q96RG1 Q9UMY9 Q9UN34

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BMRB 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 5 CDD 3 CPTAC 2 CTD 1 ChEBI 12 ChEMBL 1 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 1 DrugCentral 1 EC 2 EMBL 13 Ensembl 6 EvolutionaryTrace 1 ExpressionAtlas 1 GO 17 Gene3D 3 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 GuidetoPHARMACOLOGY 1 HGNC 1 HPA 1 InParanoid 1 IntAct 1 InterPro 8 KEGG 1 MANE-Select 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 MetOSite 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 3 PDBsum 3 PIR 1 PRO 1 PROSITE 5 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 3 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 Proteomes 1 ProteomicsDB 7 Pumba 1 RNAct 1 Reactome 9 RefSeq 5 Rhea 6 SIGNOR 1 SMART 2 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 TreeFam 1 UCSC 4 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9543386

Title: C-TAK1 protein kinase phosphorylates human Cdc25C on serine 216 and promotes 14-3-3 protein binding.

PubMed ID: 9543386

PubMed ID: 11433294

Title: PAR-1 is a Dishevelled-associated kinase and a positive regulator of Wnt signalling.

PubMed ID: 11433294

DOI: 10.1038/35083016

PubMed ID: 12508121

Title: The DNA sequence and analysis of human chromosome 14.

PubMed ID: 12508121

DOI: 10.1038/nature01348

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 12941695

Title: Functional analysis of C-TAK1 substrate binding and identification of PKP2 as a new C-TAK1 substrate.

PubMed ID: 12941695

DOI: 10.1093/emboj/cdg426

PubMed ID: 15084291

Title: Atypical PKC phosphorylates PAR-1 kinases to regulate localization and activity.

PubMed ID: 15084291

DOI: 10.1016/j.cub.2004.04.007

PubMed ID: 14976552

Title: LKB1 is a master kinase that activates 13 kinases of the AMPK subfamily, including MARK/PAR-1.

PubMed ID: 14976552

DOI: 10.1038/sj.emboj.7600110

PubMed ID: 16822840

Title: Microphthalmia-associated transcription factor interactions with 14-3-3 modulate differentiation of committed myeloid precursors.

PubMed ID: 16822840

DOI: 10.1091/mbc.e06-05-0470

PubMed ID: 16980613

Title: New role for hPar-1 kinases EMK and C-TAK1 in regulating localization and activity of class IIa histone deacetylases.

PubMed ID: 16980613

DOI: 10.1128/mcb.00231-06

PubMed ID: 16959763

Title: Transgenic mouse proteomics identifies new 14-3-3-associated proteins involved in cytoskeletal rearrangements and cell signaling.

PubMed ID: 16959763

DOI: 10.1074/mcp.m600147-mcp200

PubMed ID: 18220336

Title: Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis.

PubMed ID: 18220336

DOI: 10.1021/pr0705441

PubMed ID: 18691976

Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.

PubMed ID: 18691976

DOI: 10.1016/j.molcel.2008.07.007

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 19369195

Title: Large-scale proteomics analysis of the human kinome.

PubMed ID: 19369195

DOI: 10.1074/mcp.m800588-mcp200

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 21145462

Title: Kinase associated-1 domains drive MARK/PAR1 kinases to membrane targets by binding acidic phospholipids.

PubMed ID: 21145462

DOI: 10.1016/j.cell.2010.11.028

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 23666762

Title: Role of individual MARK isoforms in phosphorylation of tau at Ser262 in Alzheimer's disease.

PubMed ID: 23666762

DOI: 10.1007/s12017-013-8232-3

PubMed ID: 28087714

Title: DLG5 connects cell polarity and Hippo signaling protein networks by linking PAR-1 with MST1/2.

PubMed ID: 28087714

DOI: 10.1101/gad.284539.116

PubMed ID: 17344846

Title: Patterns of somatic mutation in human cancer genomes.

PubMed ID: 17344846

DOI: 10.1038/nature05610

PubMed ID: 29771303

Title: Visual impairment and progressive phthisis bulbi caused by recessive pathogenic variant in MARK3.

PubMed ID: 29771303

DOI: 10.1093/hmg/ddy180

Sequence Information:

  • Length: 753
  • Mass: 84429
  • Checksum: B50B3C145E896B0B
  • Sequence:
    • MSTRTPLPTV NERDTENHTS HGDGRQEVTS RTSRSGARCR NSIASCADEQ PHIGNYRLLK 
TIGKGNFAKV KLARHILTGR EVAIKIIDKT QLNPTSLQKL FREVRIMKIL NHPNIVKLFE 
VIETEKTLYL IMEYASGGEV FDYLVAHGRM KEKEARSKFR QIVSAVQYCH QKRIVHRDLK 
AENLLLDADM NIKIADFGFS NEFTVGGKLD TFCGSPPYAA PELFQGKKYD GPEVDVWSLG 
VILYTLVSGS LPFDGQNLKE LRERVLRGKY RIPFYMSTDC ENLLKRFLVL NPIKRGTLEQ 
IMKDRWINAG HEEDELKPFV EPELDISDQK RIDIMVGMGY SQEEIQESLS KMKYDEITAT 
YLLLGRKSSE LDASDSSSSS NLSLAKVRPS SDLNNSTGQS PHHKVQRSVS SSQKQRRYSD 
HAGPAIPSVV AYPKRSQTST ADSDLKEDGI SSRKSSGSAV GGKGIAPASP MLGNASNPNK 
ADIPERKKSS TVPSSNTASG GMTRRNTYVC SERTTADRHS VIQNGKENST IPDQRTPVAS 
THSISSAATP DRIRFPRGTA SRSTFHGQPR ERRTATYNGP PASPSLSHEA TPLSQTRSRG 
STNLFSKLTS KLTRRNMSFR FIKRLPTEYE RNGRYEGSSR NVSAEQKDEN KEAKPRSLRF 
TWSMKTTSSM DPGDMMREIR KVLDANNCDY EQRERFLLFC VHGDGHAENL VQWEMEVCKL 
PRLSLNGVRF KRISGTSIAF KNIASKIANE LKL

Genular Protein ID: 3622270083

Symbol: A0A7I2V639_HUMAN

Name: N/A

UniProtKB Accession Codes:

A0A7I2V639

Database IDs:

ARBA 7 AlphaFoldDB 1 Bgee 1 CDD 2 CTD 1 ChEBI 10 DisGeNET 1 EC 2 EMBL 2 Ensembl 2 GO 2 Gene3D 3 GeneTree 1 HGNC 1 InterPro 6 NCBI Taxonomy 1 PANTHER 2 PROSITE 7 PeptideAtlas 2 Pfam 3 Proteomes 2 ProteomicsDB 1 RefSeq 1 Rhea 6 SAM 1 SMART 2 SMR 1 SUPFAM 2

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 12508121

Title: The DNA sequence and analysis of human chromosome 14.

PubMed ID: 12508121

DOI: 10.1038/nature01348

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

Sequence Information:

  • Length: 689
  • Mass: 77402
  • Checksum: 91F9C179344F74B7
  • Sequence:
    • MSTRTPLPTV NERDTENVAI KIIDKTQLNP TSLQKLFREV RIMKILNHPN IVKLFEVIET 
EKTLYLIMEY ASGGEVFDYL VAHGRMKEKE ARSKFRQIVS AVQYCHQKRI VHRDLKAENL 
LLDADMNIKI ADFGFSNEFT VGGKLDTFCG SPPYAAPELF QGKKYDGPEV DVWSLGVILY 
TLVSGSLPFD GQNLKELRER VLRGKYRIPF YMSTDCENLL KRFLVLNPIK RGTLEQIMKD 
RWINAGHEED ELKPFVEPEL DISDQKRIDI MVGMGYSQEE IQESLSKMKY DEITATYLLL 
GRKSSELDAS DSSSSSNLSL AKVRPSSDLN NSTGQSPHHK VQRSVSSSQK QRRYSDHAGP 
AIPSVVAYPK RSQTSTADSD LKEDGISSRK SSGSAVGGKG IAPASPMLGN ASNPNKADIP 
ERKKSSTVPS SNTASGGMTR RNTYVCSERT TADRHSVIQN GKENSTIPDQ RTPVASTHSI 
SSAATPDRIR FPRGTASRST FHGQPRERRT ATYNGPPASP SLSHEATPLS QTRSRGSTNL 
FSKLTSKLTR RNMSFRFIKR LPTEYERNGR YEGSSRNVSA EQKDENKEAK PRSLRFTWSM 
KTTSSMDPGD MMREIRKVLD ANNCDYEQRE RFLLFCVHGD GHAENLVQWE MEVCKLPRLS 
LNGVRFKRIS GTSIAFKNIA SKIANELKL

Genular Protein ID: 149819479

Symbol: A0A7I2YQF7_HUMAN

Name: N/A

UniProtKB Accession Codes:

A0A7I2YQF7

Database IDs:

ARBA 8 AlphaFoldDB 1 Bgee 1 CDD 3 CTD 1 ChEBI 11 DisGeNET 1 EC 2 EMBL 2 Ensembl 2 GO 3 Gene3D 3 GeneTree 1 HGNC 1 InterPro 8 NCBI Taxonomy 1 PANTHER 2 PROSITE 8 PROSITE-ProRule 1 PeptideAtlas 2 Pfam 3 Proteomes 2 ProteomicsDB 1 RefSeq 1 Rhea 6 SAM 1 SMART 2 SMR 1 SUPFAM 2

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 12508121

Title: The DNA sequence and analysis of human chromosome 14.

PubMed ID: 12508121

DOI: 10.1038/nature01348

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

Sequence Information:

  • Length: 738
  • Mass: 82620
  • Checksum: 1AA6201EA2F3C873
  • Sequence:
    • MSTRTPLPTV NERDTENHTS HGDGRQEVTS RTSRSGARCR NSIASCADEQ PHIGNYRLLK 
TIGKGNFAKV KLARHILTGR EVAIKIIDKT QLNPTSLQKL FREVRIMKIL NHPNIVKLFE 
VIETEKTLYL IMEYASGGEV FDYLVAHGRM KEKEARSKFR QIVSAVQYCH QKRIVHRDLK 
AENLLLDADM NIKIADFGFS NEFTVGGKLD TFCGSPPYAA PELFQGKKYD GPEVDVWSLG 
VILYTLVSGS LPFDGQNLKE LRERVLRGKY RIPFYMSTDC ENLLKRFLVL NPIKRGTLEQ 
IMKDRWINAG HEEDELKPFV EPELDISDQK RIDIMVGMGY SQEEIQESLS KMKYDEITAT 
YLLLGRKSSE LDASDSSSSS NLSLAKVRPS SDLNNSTGQS PHHKVQRSVS SSQKQRRYSD 
HAGPAIPSVV AYPKRSQTST ADSDLKEDGI SSRKSSGSAV GGKGIAPASP MLGNASNPNK 
ADIPERKKSS TVPSSNTASG GMTRRNTYVC SERTTADRHS VIQNGKENST IPDQRTPVAS 
THSISSAATP DRIRFPRGTA SRSTFHGQPR ERRTATYNGP PASPSLSHEA TPLSQTRSRG 
STNLFSKLTS KLTRRNMSFR FIKSRNVSAE QKDENKEAKP RSLRFTWSMK TTSSMDPGDM 
MREIRKVLDA NNCDYEQRER FLLFCVHGDG HAENLVQWEM EVCKLPRLSL NGVRFKRISG 
TSIAFKNIAS KIANELKL

Genular Protein ID: 4248190124

Symbol: A0A7I2V2E3_HUMAN

Name: N/A

UniProtKB Accession Codes:

A0A7I2V2E3

Database IDs:

ARBA 7 AlphaFoldDB 1 Bgee 1 CDD 2 CTD 1 ChEBI 10 DisGeNET 1 EC 2 EMBL 2 Ensembl 2 GO 2 Gene3D 3 GeneTree 1 HGNC 1 InterPro 6 NCBI Taxonomy 1 PANTHER 2 PROSITE 7 PeptideAtlas 2 Pfam 3 Proteomes 2 ProteomicsDB 1 RefSeq 2 Rhea 6 SAM 1 SMART 2 SMR 1 SUPFAM 2

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 12508121

Title: The DNA sequence and analysis of human chromosome 14.

PubMed ID: 12508121

DOI: 10.1038/nature01348

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

Sequence Information:

  • Length: 622
  • Mass: 69570
  • Checksum: 5D0F2DE5A45843F7
  • Sequence:
    • MEYASGGEVF DYLVAHGRMK EKEARSKFRQ IVSAVQYCHQ KRIVHRDLKA ENLLLDADMN 
IKIADFGFSN EFTVGGKLDT FCGSPPYAAP ELFQGKKYDG PEVDVWSLGV ILYTLVSGSL 
PFDGQNLKEL RERVLRGKYR IPFYMSTDCE NLLKRFLVLN PIKRGTLEQI MKDRWINAGH 
EEDELKPFVE PELDISDQKR IDIMVGMGYS QEEIQESLSK MKYDEITATY LLLGRKSSEL 
DASDSSSSSN LSLAKVRPSS DLNNSTGQSP HHKVQRSVSS SQKQRRYSDH AGPAIPSVVA 
YPKRSQTSTA DSDLKEDGIS SRKSSGSAVG GKGIAPASPM LGNASNPNKA DIPERKKSST 
VPSSNTASGG MTRRNTYVCS ERTTADRHSV IQNGKENSTI PDQRTPVAST HSISSAATPD 
RIRFPRGTAS RSTFHGQPRE RRTATYNGPP ASPSLSHEAT PLSQTRSRGS TNLFSKLTSK 
LTRRNMSFRF IKRLPTEYER NGRYEGSSRN VSAEQKDENK EAKPRSLRFT WSMKTTSSMD 
PGDMMREIRK VLDANNCDYE QRERFLLFCV HGDGHAENLV QWEMEVCKLP RLSLNGVRFK 
RISGTSIAFK NIASKIANEL KL

Genular Protein ID: 2442952323

Symbol: H0YNV4_HUMAN

Name: N/A

UniProtKB Accession Codes:

H0YNV4

Database IDs:

ARBA 8 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 CDD 3 CTD 1 ChEBI 11 ChiTaRS 1 DisGeNET 1 EC 2 EMBL 2 Ensembl 2 ExpressionAtlas 1 GO 3 Gene3D 3 GeneTree 1 HGNC 1 HOGENOM 1 InterPro 8 MassIVE 1 NCBI Taxonomy 1 PANTHER 2 PROSITE 8 PROSITE-ProRule 1 PeptideAtlas 2 Pfam 3 Proteomes 2 ProteomicsDB 2 RefSeq 1 Rhea 6 SAM 1 SMART 2 SMR 1 SUPFAM 2 UCSC 1 VEuPathDB 1

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 12508121

Title: The DNA sequence and analysis of human chromosome 14.

PubMed ID: 12508121

DOI: 10.1038/nature01348

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

PubMed ID: 18691976

Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.

PubMed ID: 18691976

DOI: 10.1016/j.molcel.2008.07.007

PubMed ID: 19369195

Title: Large-scale proteomics analysis of the human kinome.

PubMed ID: 19369195

DOI: 10.1074/mcp.M800588-MCP200

Sequence Information:

  • Length: 643
  • Mass: 72123
  • Checksum: 6C810A5C6C1251FC
  • Sequence:
    • MSTRTPLPTV NERDTENHTS HGDGRQEVTS RTSRSGARCR NSIASCADEQ PHIGNYRLLK 
TIGKGNFAKV KLARHILTGR EVAIKIIDKT QLNPTSLQKL FREVRIMKIL NHPNIVKLFE 
VIETEKTLYL IMEYASGGEV FDYLVAHGRM KEKEARSKFR QIVSAVQYCH QKRIVHRDLK 
AENLLLDADM NIKIADFGFS NEFTVGGKLD TFCGSPPYAA PELFQGKKYD GPEVDVWSLG 
VILYTLVSGS LPFDGQNLKE LRERVLRGKY RIPFYMSTDC ENLLKRFLVL NPIKRGTLEQ 
IMKDRWINAG HEEDELKPFV EPELDISDQK RIDIMVGMGY SQEEIQESLS KMKYDEITAT 
YLLLGRKSSE LDASDSSSSS NLSLAKVRPS SDLNNSTGQS PHHKVQRSVS SSQKQRRYSD 
HAGPAIPSVV AYPKRSQTST ADSDLKEDGI SSRKSSGSAV GGKGIAPASP MLGNASNPNK 
ADIPERKKSS TVPSSNTASG GMTRRNTYVC SERTTADRHS VIQNGKENSR NVSAEQKDEN 
KEAKPRSLRF TWSMKTTSSM DPGDMMREIR KVLDANNCDY EQRERFLLFC VHGDGHAENL 
VQWEMEVCKL PRLSLNGVRF KRISGTSIAF KNIASKIANE LKL

Genular Protein ID: 1419770259

Symbol: A0A7I2V3B9_HUMAN

Name: N/A

UniProtKB Accession Codes:

A0A7I2V3B9

Database IDs:

ARBA 7 AlphaFoldDB 1 Bgee 1 CDD 2 CTD 1 ChEBI 10 DisGeNET 1 EC 2 EMBL 2 Ensembl 2 GO 2 Gene3D 3 GeneTree 1 HGNC 1 InterPro 6 NCBI Taxonomy 1 PANTHER 2 PROSITE 7 PeptideAtlas 2 Pfam 3 Proteomes 2 ProteomicsDB 1 RefSeq 1 Rhea 6 SAM 1 SMART 2 SMR 1 SUPFAM 2

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 12508121

Title: The DNA sequence and analysis of human chromosome 14.

PubMed ID: 12508121

DOI: 10.1038/nature01348

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

Sequence Information:

  • Length: 665
  • Mass: 74412
  • Checksum: E77B72D4497CD12A
  • Sequence:
    • MSTRTPLPTV NERDTENVAI KIIDKTQLNP TSLQKLFREV RIMKILNHPN IVKLFEVIET 
EKTLYLIMEY ASGGEVFDYL VAHGRMKEKE ARSKFRQIVS AVQYCHQKRI VHRDLKAENL 
LLDADMNIKI ADFGFSNEFT VGGKLDTFCG SPPYAAPELF QGKKYDGPEV DVWSLGVILY 
TLVSGSLPFD GQNLKELRER VLRGKYRIPF YMSTDCENLL KRFLVLNPIK RGTLEQIMKD 
RWINAGHEED ELKPFVEPEL DISDQKRIDI MVGMGYSQEE IQESLSKMKY DEITATYLLL 
GRKSSELDAS DSSSSSNLSL AKVRPSSDLN NSTGQSPHHK VQRSVSSSQK QRRYSDHAGP 
AIPSVVAYPK RSQTSTADSD LKEDGISSRK SSGSAVGGKG IAPASPMLGN ASNPNKADIP 
ERKKSSTVPS SNTASGGMTR RNTYVCSERT TADRHSVIQN GKENSTIPDQ RTPVASTHSI 
SSAATPDRIR FPRGTASRST FHGQPRERRT ATYNGPPASP SLSHEATPLS QTRSRGSTNL 
FSKLTSKLTR SRNVSAEQKD ENKEAKPRSL RFTWSMKTTS SMDPGDMMRE IRKVLDANNC 
DYEQRERFLL FCVHGDGHAE NLVQWEMEVC KLPRLSLNGV RFKRISGTSI AFKNIASKIA 
NELKL

Genular Protein ID: 2222575158

Symbol: Q86U11_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q86U11

Database IDs:

ARBA 2 AlphaFoldDB 1 BioGRID-ORCS 1 CDD 2 CTD 1 DNASU 1 DisGeNET 1 EMBL 2 GO 3 Gene3D 2 InterPro 3 KEGG 1 NCBI Taxonomy 1 OrthoDB 1 PROSITE 4 PeptideAtlas 1 Pfam 2 PharmGKB 1 RefSeq 2 SAM 1 SMART 1 SUPFAM 1

Sequence Information:

  • Length: 431
  • Mass: 47708
  • Checksum: 4C47EA42E30FEC68
  • Sequence:
    • ELDISDQKRI DIMVGMGYSQ EEIQESLSKM KYDEITATYL LLGRKSSELD ASDSSSSSNL 
SLAKVRPSSD LNNSTGQSPH HKVQRSVFSS QKQRRYSDHA GPAIPSVVAY PKRSQTSTAD 
SDLKEDGISS RKSSGSAVGG KGIAPASPML GNASNPNKAD IPERKKSSTV PSSNTASGGM 
TRRNTYVCSE RTTADRHSVI QNGKENSTIP DQRTPVASTH SISSAATPDR IRFPRGTASR 
STFHGQPRER RTATYNGPPA SPSLSHEATP LSQTRSRGST NLFSKLTSKL TRRNMSFRFI 
KRLPTEYERN GRYEGSSRNV SAEQKDENKE AKPRSLRFTW SMKTTSSMDP GDMMREIRKV 
LDANNCDYEQ RERFLLFCVH GDGHAENLVQ WEMEVCKLPR LSLNGVRFKR ISGTSIAFKN 
IASKIANELK L

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.