Details for: MARK3

Gene ID: 4140

Symbol: MARK3

Ensembl ID: ENSG00000075413

Description: microtubule affinity regulating kinase 3

Associated with

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: 4.95
    Marker Score: 20,647
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: 3.63
    Marker Score: 81,031
  • Cell Name: stellate neuron (CL0000122)
    Fold Change: 3.25
    Marker Score: 17,475
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 3.01
    Marker Score: 12,618
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 2.98
    Marker Score: 100,679
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 2.96
    Marker Score: 63,199
  • Cell Name: kidney interstitial fibroblast (CL1000692)
    Fold Change: 2.9
    Marker Score: 5,570
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 2.81
    Marker Score: 6,168
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 2.76
    Marker Score: 3,713
  • Cell Name: granule cell (CL0000120)
    Fold Change: 2.76
    Marker Score: 20,808
  • Cell Name: taste receptor cell (CL0000209)
    Fold Change: 2.66
    Marker Score: 2,301
  • Cell Name: renal principal cell (CL0005009)
    Fold Change: 2.66
    Marker Score: 2,049
  • Cell Name: macroglial cell (CL0000126)
    Fold Change: 2.65
    Marker Score: 6,081
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 2.64
    Marker Score: 46,948
  • Cell Name: mature astrocyte (CL0002627)
    Fold Change: 2.64
    Marker Score: 1,739
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 2.58
    Marker Score: 3,122
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: 2.56
    Marker Score: 2,946
  • Cell Name: corneal endothelial cell (CL0000132)
    Fold Change: 2.51
    Marker Score: 1,463
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 2.49
    Marker Score: 729
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 2.49
    Marker Score: 49,587
  • Cell Name: alveolar type 2 fibroblast cell (CL4028006)
    Fold Change: 2.49
    Marker Score: 1,385
  • Cell Name: neuron associated cell (sensu Vertebrata) (CL0000123)
    Fold Change: 2.49
    Marker Score: 13,062
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: 2.48
    Marker Score: 37,095
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 2.46
    Marker Score: 93,524
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: 2.46
    Marker Score: 18,836
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: 2.39
    Marker Score: 5,718
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 2.37
    Marker Score: 2,681
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 2.33
    Marker Score: 37,459
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: 2.33
    Marker Score: 10,792
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 2.33
    Marker Score: 1,228
  • Cell Name: cardiac neuron (CL0010022)
    Fold Change: 2.33
    Marker Score: 2,901
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: 2.3
    Marker Score: 725
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: 2.26
    Marker Score: 9,380
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 2.26
    Marker Score: 1,320
  • Cell Name: contractile cell (CL0000183)
    Fold Change: 2.24
    Marker Score: 1,212
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 2.24
    Marker Score: 82,485
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 2.23
    Marker Score: 1,333
  • Cell Name: A2 amacrine cell (CL0004219)
    Fold Change: 2.22
    Marker Score: 705
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 2.21
    Marker Score: 2,439
  • Cell Name: OFF retinal ganglion cell (CL4023033)
    Fold Change: 2.2
    Marker Score: 922
  • Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 2.18
    Marker Score: 8,417
  • Cell Name: epithelial cell of prostate (CL0002231)
    Fold Change: 2.17
    Marker Score: 1,504
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: 2.13
    Marker Score: 7,579
  • Cell Name: mesangial cell (CL0000650)
    Fold Change: 2.12
    Marker Score: 2,554
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: 2.1
    Marker Score: 1,384
  • Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
    Fold Change: 2.08
    Marker Score: 2,244
  • Cell Name: fat cell (CL0000136)
    Fold Change: 2.08
    Marker Score: 1,162
  • Cell Name: basal epithelial cell of prostatic duct (CL0002236)
    Fold Change: 2.07
    Marker Score: 1,840
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 2.07
    Marker Score: 5,188
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 2.06
    Marker Score: 19,419
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 2.01
    Marker Score: 123,850
  • Cell Name: lung goblet cell (CL1000143)
    Fold Change: 2.01
    Marker Score: 579
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 1.99
    Marker Score: 1,722
  • Cell Name: epithelial cell of lower respiratory tract (CL0002632)
    Fold Change: 1.97
    Marker Score: 8,217
  • Cell Name: neuronal brush cell (CL0000555)
    Fold Change: 1.94
    Marker Score: 6,520
  • Cell Name: photoreceptor cell (CL0000210)
    Fold Change: 1.94
    Marker Score: 1,457
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 1.92
    Marker Score: 948
  • Cell Name: renal interstitial pericyte (CL1001318)
    Fold Change: 1.92
    Marker Score: 1,826
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: 1.91
    Marker Score: 2,777
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 1.87
    Marker Score: 19,321
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 1.86
    Marker Score: 17,653
  • Cell Name: podocyte (CL0000653)
    Fold Change: 1.85
    Marker Score: 684
  • Cell Name: central nervous system macrophage (CL0000878)
    Fold Change: 1.82
    Marker Score: 903
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 1.82
    Marker Score: 15,598
  • Cell Name: neuron (CL0000540)
    Fold Change: 1.79
    Marker Score: 7,301
  • Cell Name: mature microglial cell (CL0002629)
    Fold Change: 1.79
    Marker Score: 648
  • Cell Name: parietal epithelial cell (CL1000452)
    Fold Change: 1.78
    Marker Score: 648
  • Cell Name: endothelial cell of pericentral hepatic sinusoid (CL0019022)
    Fold Change: 1.78
    Marker Score: 1,910
  • Cell Name: cerebral cortex neuron (CL0010012)
    Fold Change: 1.77
    Marker Score: 5,048
  • Cell Name: epicardial adipocyte (CL1000309)
    Fold Change: 1.77
    Marker Score: 858
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 1.72
    Marker Score: 1,815
  • Cell Name: smooth muscle cell of prostate (CL1000487)
    Fold Change: 1.71
    Marker Score: 436
  • Cell Name: pyramidal neuron (CL0000598)
    Fold Change: 1.71
    Marker Score: 2,865
  • Cell Name: kidney connecting tubule epithelial cell (CL1000768)
    Fold Change: 1.7
    Marker Score: 2,406
  • Cell Name: ON retinal ganglion cell (CL4023032)
    Fold Change: 1.69
    Marker Score: 463
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: 1.66
    Marker Score: 2,057
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 1.63
    Marker Score: 556
  • Cell Name: brainstem motor neuron (CL2000047)
    Fold Change: 1.63
    Marker Score: 944
  • Cell Name: cholangiocyte (CL1000488)
    Fold Change: 1.62
    Marker Score: 605
  • Cell Name: cerebellar granule cell precursor (CL0002362)
    Fold Change: 1.62
    Marker Score: 906
  • Cell Name: rod bipolar cell (CL0000751)
    Fold Change: 1.6
    Marker Score: 837
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: 1.6
    Marker Score: 5,243
  • Cell Name: subcutaneous fat cell (CL0002521)
    Fold Change: 1.58
    Marker Score: 576
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.56
    Marker Score: 2,295
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 1.55
    Marker Score: 2,389
  • Cell Name: erythroblast (CL0000765)
    Fold Change: 1.54
    Marker Score: 963
  • Cell Name: type II pneumocyte (CL0002063)
    Fold Change: 1.53
    Marker Score: 9,998
  • Cell Name: mesothelial cell of epicardium (CL0011019)
    Fold Change: 1.52
    Marker Score: 489
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: 1.52
    Marker Score: 1,036
  • Cell Name: syncytiotrophoblast cell (CL0000525)
    Fold Change: 1.51
    Marker Score: 1,241
  • Cell Name: melanocyte (CL0000148)
    Fold Change: 1.5
    Marker Score: 609
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 1.49
    Marker Score: 574
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: 1.49
    Marker Score: 1,581
  • Cell Name: skin fibroblast (CL0002620)
    Fold Change: 1.47
    Marker Score: 381
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: 1.45
    Marker Score: 5,149
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 1.44
    Marker Score: 345
  • Cell Name: basal cell (CL0000646)
    Fold Change: 1.44
    Marker Score: 1,860
  • Cell Name: choroid plexus epithelial cell (CL0000706)
    Fold Change: 1.42
    Marker Score: 1,303
  • Cell Name: endocrine cell (CL0000163)
    Fold Change: 1.41
    Marker Score: 731
  • Cell Name: hepatic stellate cell (CL0000632)
    Fold Change: 1.41
    Marker Score: 531

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** MARK3 is a member of the MAPK family, which is characterized by their ability to phosphorylate and regulate the activity of downstream targets. MARK3 is specifically known for its microtubule affinity, which allows it to interact with microtubules and regulate their dynamics. This property enables MARK3 to modulate the activity of various downstream targets, including proteins involved in cell signaling, cytoskeletal organization, and protein localization. MARK3 exhibits a unique kinase activity profile, with a preference for phosphorylating serine and threonine residues. This specificity is thought to be mediated by its microtubule-binding domain, which allows MARK3 to interact with microtubules and position its kinase domain for optimal substrate recognition. **Pathways and Functions** MARK3 is involved in multiple signaling pathways, including: 1. **MAPK signaling cascades**: MARK3 is a key regulator of the MAPK signaling pathway, which is involved in various cellular processes, including cell proliferation, differentiation, and survival. 2. **Tau-protein kinase activity**: MARK3 phosphorylates tau protein, a microtubule-associated protein that plays a crucial role in neuronal function and pathology. 3. **Protein localization to nucleus**: MARK3 regulates the localization of proteins to the nucleus, which is essential for various cellular processes, including transcriptional regulation and cell cycle progression. 4. **Negative regulation of Hippo signaling**: MARK3 negatively regulates the Hippo signaling pathway, which is involved in the regulation of cell growth and proliferation. 5. **Negative regulation of MAPK pathway**: MARK3 also negatively regulates the MAPK pathway, which is involved in various cellular processes, including cell proliferation, differentiation, and survival. **Clinical Significance** MARK3 has been implicated in various diseases, including: 1. **Neurodegenerative disorders**: MARK3 has been shown to be involved in the regulation of tau protein and its aggregation, which is thought to contribute to the pathogenesis of neurodegenerative disorders, such as Alzheimer's disease and frontotemporal dementia. 2. **Cancer**: MARK3 has been shown to be overexpressed in various types of cancer, including breast cancer and ovarian cancer, and is thought to contribute to tumor progression and metastasis. 3. **Cardiovascular disease**: MARK3 has been shown to be involved in the regulation of cardiac function and is thought to contribute to the pathogenesis of cardiovascular disease. In conclusion, MARK3 is a multifunctional kinase gene that plays a critical role in various cellular processes, including signal transduction, protein localization, and cell cycle regulation. Its involvement in disease pathogenesis highlights the importance of MARK3 as a potential therapeutic target for the treatment of various diseases.

Genular Protein ID: 3660778246

Symbol: MARK3_HUMAN

Name: MAP/microtubule affinity-regulating kinase 3

UniProtKB Accession Codes:

P27448 A0A0A0MQR8 A0A0A0MST9 A0A0A0MT23 O60219 Q86TT8 Q8TB41 Q8WX83 Q96RG1 Q9UMY9 Q9UN34

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BMRB 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 5 CDD 3 CPTAC 2 CTD 1 ChEBI 12 ChEMBL 1 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 1 DrugCentral 1 EC 2 EMBL 13 EPD 1 Ensembl 6 EvolutionaryTrace 1 ExpressionAtlas 1 GO 17 Gene3D 3 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyGen 1 GuidetoPHARMACOLOGY 1 HGNC 1 HPA 1 InParanoid 1 IntAct 1 InterPro 7 KEGG 1 MANE-Select 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 MaxQB 1 MetOSite 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 4 PDBsum 3 PIR 1 PRO 1 PROSITE 5 PROSITE-ProRule 4 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 3 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 Proteomes 1 ProteomicsDB 7 Pumba 1 RNAct 1 Reactome 9 RefSeq 5 Rhea 6 SAM 1 SIGNOR 1 SMART 2 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 TreeFam 1 UCSC 4 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9543386

Title: C-TAK1 protein kinase phosphorylates human Cdc25C on serine 216 and promotes 14-3-3 protein binding.

PubMed ID: 9543386

PubMed ID: 11433294

Title: PAR-1 is a Dishevelled-associated kinase and a positive regulator of Wnt signalling.

PubMed ID: 11433294

DOI: 10.1038/35083016

PubMed ID: 12508121

Title: The DNA sequence and analysis of human chromosome 14.

PubMed ID: 12508121

DOI: 10.1038/nature01348

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 12941695

Title: Functional analysis of C-TAK1 substrate binding and identification of PKP2 as a new C-TAK1 substrate.

PubMed ID: 12941695

DOI: 10.1093/emboj/cdg426

PubMed ID: 15084291

Title: Atypical PKC phosphorylates PAR-1 kinases to regulate localization and activity.

PubMed ID: 15084291

DOI: 10.1016/j.cub.2004.04.007

PubMed ID: 14976552

Title: LKB1 is a master kinase that activates 13 kinases of the AMPK subfamily, including MARK/PAR-1.

PubMed ID: 14976552

DOI: 10.1038/sj.emboj.7600110

PubMed ID: 16822840

Title: Microphthalmia-associated transcription factor interactions with 14-3-3 modulate differentiation of committed myeloid precursors.

PubMed ID: 16822840

DOI: 10.1091/mbc.e06-05-0470

PubMed ID: 16980613

Title: New role for hPar-1 kinases EMK and C-TAK1 in regulating localization and activity of class IIa histone deacetylases.

PubMed ID: 16980613

DOI: 10.1128/mcb.00231-06

PubMed ID: 16959763

Title: Transgenic mouse proteomics identifies new 14-3-3-associated proteins involved in cytoskeletal rearrangements and cell signaling.

PubMed ID: 16959763

DOI: 10.1074/mcp.m600147-mcp200

PubMed ID: 18220336

Title: Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis.

PubMed ID: 18220336

DOI: 10.1021/pr0705441

PubMed ID: 18691976

Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.

PubMed ID: 18691976

DOI: 10.1016/j.molcel.2008.07.007

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 19369195

Title: Large-scale proteomics analysis of the human kinome.

PubMed ID: 19369195

DOI: 10.1074/mcp.m800588-mcp200

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 21145462

Title: Kinase associated-1 domains drive MARK/PAR1 kinases to membrane targets by binding acidic phospholipids.

PubMed ID: 21145462

DOI: 10.1016/j.cell.2010.11.028

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 23666762

Title: Role of individual MARK isoforms in phosphorylation of tau at Ser262 in Alzheimer's disease.

PubMed ID: 23666762

DOI: 10.1007/s12017-013-8232-3

PubMed ID: 28087714

Title: DLG5 connects cell polarity and Hippo signaling protein networks by linking PAR-1 with MST1/2.

PubMed ID: 28087714

DOI: 10.1101/gad.284539.116

PubMed ID: 17344846

Title: Patterns of somatic mutation in human cancer genomes.

PubMed ID: 17344846

DOI: 10.1038/nature05610

PubMed ID: 29771303

Title: Visual impairment and progressive phthisis bulbi caused by recessive pathogenic variant in MARK3.

PubMed ID: 29771303

DOI: 10.1093/hmg/ddy180

Sequence Information:

  • Length: 753
  • Mass: 84429
  • Checksum: B50B3C145E896B0B
  • Sequence:
    • MSTRTPLPTV NERDTENHTS HGDGRQEVTS RTSRSGARCR NSIASCADEQ PHIGNYRLLK 
TIGKGNFAKV KLARHILTGR EVAIKIIDKT QLNPTSLQKL FREVRIMKIL NHPNIVKLFE 
VIETEKTLYL IMEYASGGEV FDYLVAHGRM KEKEARSKFR QIVSAVQYCH QKRIVHRDLK 
AENLLLDADM NIKIADFGFS NEFTVGGKLD TFCGSPPYAA PELFQGKKYD GPEVDVWSLG 
VILYTLVSGS LPFDGQNLKE LRERVLRGKY RIPFYMSTDC ENLLKRFLVL NPIKRGTLEQ 
IMKDRWINAG HEEDELKPFV EPELDISDQK RIDIMVGMGY SQEEIQESLS KMKYDEITAT 
YLLLGRKSSE LDASDSSSSS NLSLAKVRPS SDLNNSTGQS PHHKVQRSVS SSQKQRRYSD 
HAGPAIPSVV AYPKRSQTST ADSDLKEDGI SSRKSSGSAV GGKGIAPASP MLGNASNPNK 
ADIPERKKSS TVPSSNTASG GMTRRNTYVC SERTTADRHS VIQNGKENST IPDQRTPVAS 
THSISSAATP DRIRFPRGTA SRSTFHGQPR ERRTATYNGP PASPSLSHEA TPLSQTRSRG 
STNLFSKLTS KLTRRNMSFR FIKRLPTEYE RNGRYEGSSR NVSAEQKDEN KEAKPRSLRF 
TWSMKTTSSM DPGDMMREIR KVLDANNCDY EQRERFLLFC VHGDGHAENL VQWEMEVCKL 
PRLSLNGVRF KRISGTSIAF KNIASKIANE LKL

Genular Protein ID: 1419770259

Symbol: A0A7I2V3B9_HUMAN

Name: N/A

UniProtKB Accession Codes:

A0A7I2V3B9

Database IDs:

ARBA 9 AlphaFoldDB 1 Bgee 1 CDD 2 CTD 1 ChEBI 10 EC 2 EMBL 2 EPD 1 Ensembl 2 GO 3 Gene3D 3 GeneTree 1 HGNC 1 InterPro 6 MaxQB 1 NCBI Taxonomy 1 PANTHER 2 PROSITE 7 PeptideAtlas 1 Pfam 3 Proteomes 2 RefSeq 1 Rhea 6 SAM 1 SMART 2 SMR 1 SUPFAM 2

Citations:

PubMed ID: 12508121

Title: The DNA sequence and analysis of human chromosome 14.

PubMed ID: 12508121

DOI: 10.1038/nature01348

Sequence Information:

  • Length: 665
  • Mass: 74412
  • Checksum: E77B72D4497CD12A
  • Sequence:
    • MSTRTPLPTV NERDTENVAI KIIDKTQLNP TSLQKLFREV RIMKILNHPN IVKLFEVIET 
EKTLYLIMEY ASGGEVFDYL VAHGRMKEKE ARSKFRQIVS AVQYCHQKRI VHRDLKAENL 
LLDADMNIKI ADFGFSNEFT VGGKLDTFCG SPPYAAPELF QGKKYDGPEV DVWSLGVILY 
TLVSGSLPFD GQNLKELRER VLRGKYRIPF YMSTDCENLL KRFLVLNPIK RGTLEQIMKD 
RWINAGHEED ELKPFVEPEL DISDQKRIDI MVGMGYSQEE IQESLSKMKY DEITATYLLL 
GRKSSELDAS DSSSSSNLSL AKVRPSSDLN NSTGQSPHHK VQRSVSSSQK QRRYSDHAGP 
AIPSVVAYPK RSQTSTADSD LKEDGISSRK SSGSAVGGKG IAPASPMLGN ASNPNKADIP 
ERKKSSTVPS SNTASGGMTR RNTYVCSERT TADRHSVIQN GKENSTIPDQ RTPVASTHSI 
SSAATPDRIR FPRGTASRST FHGQPRERRT ATYNGPPASP SLSHEATPLS QTRSRGSTNL 
FSKLTSKLTR SRNVSAEQKD ENKEAKPRSL RFTWSMKTTS SMDPGDMMRE IRKVLDANNC 
DYEQRERFLL FCVHGDGHAE NLVQWEMEVC KLPRLSLNGV RFKRISGTSI AFKNIASKIA 
NELKL

Genular Protein ID: 4248190124

Symbol: A0A7I2V2E3_HUMAN

Name: N/A

UniProtKB Accession Codes:

A0A7I2V2E3

Database IDs:

ARBA 9 AlphaFoldDB 1 Bgee 1 CDD 2 CTD 1 ChEBI 10 EC 2 EMBL 2 EPD 1 Ensembl 2 GO 3 Gene3D 3 GeneTree 1 HGNC 1 InterPro 6 MaxQB 1 NCBI Taxonomy 1 PANTHER 2 PROSITE 7 PeptideAtlas 1 Pfam 3 Proteomes 2 RefSeq 2 Rhea 6 SAM 1 SMART 2 SMR 1 SUPFAM 2

Citations:

PubMed ID: 12508121

Title: The DNA sequence and analysis of human chromosome 14.

PubMed ID: 12508121

DOI: 10.1038/nature01348

Sequence Information:

  • Length: 622
  • Mass: 69570
  • Checksum: 5D0F2DE5A45843F7
  • Sequence:
    • MEYASGGEVF DYLVAHGRMK EKEARSKFRQ IVSAVQYCHQ KRIVHRDLKA ENLLLDADMN 
IKIADFGFSN EFTVGGKLDT FCGSPPYAAP ELFQGKKYDG PEVDVWSLGV ILYTLVSGSL 
PFDGQNLKEL RERVLRGKYR IPFYMSTDCE NLLKRFLVLN PIKRGTLEQI MKDRWINAGH 
EEDELKPFVE PELDISDQKR IDIMVGMGYS QEEIQESLSK MKYDEITATY LLLGRKSSEL 
DASDSSSSSN LSLAKVRPSS DLNNSTGQSP HHKVQRSVSS SQKQRRYSDH AGPAIPSVVA 
YPKRSQTSTA DSDLKEDGIS SRKSSGSAVG GKGIAPASPM LGNASNPNKA DIPERKKSST 
VPSSNTASGG MTRRNTYVCS ERTTADRHSV IQNGKENSTI PDQRTPVAST HSISSAATPD 
RIRFPRGTAS RSTFHGQPRE RRTATYNGPP ASPSLSHEAT PLSQTRSRGS TNLFSKLTSK 
LTRRNMSFRF IKRLPTEYER NGRYEGSSRN VSAEQKDENK EAKPRSLRFT WSMKTTSSMD 
PGDMMREIRK VLDANNCDYE QRERFLLFCV HGDGHAENLV QWEMEVCKLP RLSLNGVRFK 
RISGTSIAFK NIASKIANEL KL

Genular Protein ID: 2442952323

Symbol: H0YNV4_HUMAN

Name: N/A

UniProtKB Accession Codes:

H0YNV4

Database IDs:

ARBA 9 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 CDD 3 CTD 1 ChEBI 11 ChiTaRS 1 EC 2 EMBL 2 EPD 1 Ensembl 2 ExpressionAtlas 1 GO 3 Gene3D 3 GeneTree 1 HGNC 1 HOGENOM 1 InterPro 7 MassIVE 1 MaxQB 2 NCBI Taxonomy 1 PANTHER 2 PROSITE 8 PROSITE-ProRule 1 PeptideAtlas 1 Pfam 3 Proteomes 2 ProteomicsDB 1 RefSeq 1 Rhea 6 SAM 1 SMART 2 SMR 1 SUPFAM 2 UCSC 1 VEuPathDB 1

Citations:

PubMed ID: 12508121

Title: The DNA sequence and analysis of human chromosome 14.

PubMed ID: 12508121

DOI: 10.1038/nature01348

PubMed ID: 18691976

Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.

PubMed ID: 18691976

DOI: 10.1016/j.molcel.2008.07.007

PubMed ID: 19369195

Title: Large-scale proteomics analysis of the human kinome.

PubMed ID: 19369195

DOI: 10.1074/mcp.M800588-MCP200

Sequence Information:

  • Length: 643
  • Mass: 72123
  • Checksum: 6C810A5C6C1251FC
  • Sequence:
    • MSTRTPLPTV NERDTENHTS HGDGRQEVTS RTSRSGARCR NSIASCADEQ PHIGNYRLLK 
TIGKGNFAKV KLARHILTGR EVAIKIIDKT QLNPTSLQKL FREVRIMKIL NHPNIVKLFE 
VIETEKTLYL IMEYASGGEV FDYLVAHGRM KEKEARSKFR QIVSAVQYCH QKRIVHRDLK 
AENLLLDADM NIKIADFGFS NEFTVGGKLD TFCGSPPYAA PELFQGKKYD GPEVDVWSLG 
VILYTLVSGS LPFDGQNLKE LRERVLRGKY RIPFYMSTDC ENLLKRFLVL NPIKRGTLEQ 
IMKDRWINAG HEEDELKPFV EPELDISDQK RIDIMVGMGY SQEEIQESLS KMKYDEITAT 
YLLLGRKSSE LDASDSSSSS NLSLAKVRPS SDLNNSTGQS PHHKVQRSVS SSQKQRRYSD 
HAGPAIPSVV AYPKRSQTST ADSDLKEDGI SSRKSSGSAV GGKGIAPASP MLGNASNPNK 
ADIPERKKSS TVPSSNTASG GMTRRNTYVC SERTTADRHS VIQNGKENSR NVSAEQKDEN 
KEAKPRSLRF TWSMKTTSSM DPGDMMREIR KVLDANNCDY EQRERFLLFC VHGDGHAENL 
VQWEMEVCKL PRLSLNGVRF KRISGTSIAF KNIASKIANE LKL

Genular Protein ID: 149819479

Symbol: A0A7I2YQF7_HUMAN

Name: N/A

UniProtKB Accession Codes:

A0A7I2YQF7

Database IDs:

ARBA 9 AlphaFoldDB 1 Bgee 1 CDD 3 CTD 1 ChEBI 11 EC 2 EMBL 2 EPD 1 Ensembl 2 GO 3 Gene3D 3 GeneTree 1 HGNC 1 InterPro 7 MaxQB 1 NCBI Taxonomy 1 PANTHER 2 PROSITE 8 PROSITE-ProRule 1 PeptideAtlas 1 Pfam 3 Proteomes 2 RefSeq 1 Rhea 6 SAM 1 SMART 2 SMR 1 SUPFAM 2

Citations:

PubMed ID: 12508121

Title: The DNA sequence and analysis of human chromosome 14.

PubMed ID: 12508121

DOI: 10.1038/nature01348

Sequence Information:

  • Length: 738
  • Mass: 82620
  • Checksum: 1AA6201EA2F3C873
  • Sequence:
    • MSTRTPLPTV NERDTENHTS HGDGRQEVTS RTSRSGARCR NSIASCADEQ PHIGNYRLLK 
TIGKGNFAKV KLARHILTGR EVAIKIIDKT QLNPTSLQKL FREVRIMKIL NHPNIVKLFE 
VIETEKTLYL IMEYASGGEV FDYLVAHGRM KEKEARSKFR QIVSAVQYCH QKRIVHRDLK 
AENLLLDADM NIKIADFGFS NEFTVGGKLD TFCGSPPYAA PELFQGKKYD GPEVDVWSLG 
VILYTLVSGS LPFDGQNLKE LRERVLRGKY RIPFYMSTDC ENLLKRFLVL NPIKRGTLEQ 
IMKDRWINAG HEEDELKPFV EPELDISDQK RIDIMVGMGY SQEEIQESLS KMKYDEITAT 
YLLLGRKSSE LDASDSSSSS NLSLAKVRPS SDLNNSTGQS PHHKVQRSVS SSQKQRRYSD 
HAGPAIPSVV AYPKRSQTST ADSDLKEDGI SSRKSSGSAV GGKGIAPASP MLGNASNPNK 
ADIPERKKSS TVPSSNTASG GMTRRNTYVC SERTTADRHS VIQNGKENST IPDQRTPVAS 
THSISSAATP DRIRFPRGTA SRSTFHGQPR ERRTATYNGP PASPSLSHEA TPLSQTRSRG 
STNLFSKLTS KLTRRNMSFR FIKSRNVSAE QKDENKEAKP RSLRFTWSMK TTSSMDPGDM 
MREIRKVLDA NNCDYEQRER FLLFCVHGDG HAENLVQWEM EVCKLPRLSL NGVRFKRISG 
TSIAFKNIAS KIANELKL

Genular Protein ID: 2222575158

Symbol: Q86U11_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q86U11

Database IDs:

ARBA 8 AlphaFoldDB 1 BioGRID-ORCS 1 CDD 2 CTD 1 ChEBI 10 DNASU 1 EC 2 EMBL 2 GO 4 Gene3D 2 Genevisible 1 GenomeRNAi 1 InterPro 3 KEGG 1 NCBI Taxonomy 1 OrthoDB 1 PROSITE 4 PeptideAtlas 1 Pfam 2 PharmGKB 1 RefSeq 2 Rhea 6 SAM 1 SMART 1 SUPFAM 1

Sequence Information:

  • Length: 431
  • Mass: 47708
  • Checksum: 4C47EA42E30FEC68
  • Sequence:
    • ELDISDQKRI DIMVGMGYSQ EEIQESLSKM KYDEITATYL LLGRKSSELD ASDSSSSSNL 
SLAKVRPSSD LNNSTGQSPH HKVQRSVFSS QKQRRYSDHA GPAIPSVVAY PKRSQTSTAD 
SDLKEDGISS RKSSGSAVGG KGIAPASPML GNASNPNKAD IPERKKSSTV PSSNTASGGM 
TRRNTYVCSE RTTADRHSVI QNGKENSTIP DQRTPVASTH SISSAATPDR IRFPRGTASR 
STFHGQPRER RTATYNGPPA SPSLSHEATP LSQTRSRGST NLFSKLTSKL TRRNMSFRFI 
KRLPTEYERN GRYEGSSRNV SAEQKDENKE AKPRSLRFTW SMKTTSSMDP GDMMREIRKV 
LDANNCDYEQ RERFLLFCVH GDGHAENLVQ WEMEVCKLPR LSLNGVRFKR ISGTSIAFKN 
IASKIANELK L

Genular Protein ID: 3622270083

Symbol: A0A7I2V639_HUMAN

Name: N/A

UniProtKB Accession Codes:

A0A7I2V639

Database IDs:

ARBA 9 AlphaFoldDB 1 Bgee 1 CDD 2 CTD 1 ChEBI 10 EC 2 EMBL 2 EPD 1 Ensembl 2 GO 3 Gene3D 3 GeneTree 1 HGNC 1 InterPro 6 MaxQB 1 NCBI Taxonomy 1 PANTHER 2 PROSITE 7 PeptideAtlas 1 Pfam 3 Proteomes 2 RefSeq 1 Rhea 6 SAM 1 SMART 2 SMR 1 SUPFAM 2

Citations:

PubMed ID: 12508121

Title: The DNA sequence and analysis of human chromosome 14.

PubMed ID: 12508121

DOI: 10.1038/nature01348

Sequence Information:

  • Length: 689
  • Mass: 77402
  • Checksum: 91F9C179344F74B7
  • Sequence:
    • MSTRTPLPTV NERDTENVAI KIIDKTQLNP TSLQKLFREV RIMKILNHPN IVKLFEVIET 
EKTLYLIMEY ASGGEVFDYL VAHGRMKEKE ARSKFRQIVS AVQYCHQKRI VHRDLKAENL 
LLDADMNIKI ADFGFSNEFT VGGKLDTFCG SPPYAAPELF QGKKYDGPEV DVWSLGVILY 
TLVSGSLPFD GQNLKELRER VLRGKYRIPF YMSTDCENLL KRFLVLNPIK RGTLEQIMKD 
RWINAGHEED ELKPFVEPEL DISDQKRIDI MVGMGYSQEE IQESLSKMKY DEITATYLLL 
GRKSSELDAS DSSSSSNLSL AKVRPSSDLN NSTGQSPHHK VQRSVSSSQK QRRYSDHAGP 
AIPSVVAYPK RSQTSTADSD LKEDGISSRK SSGSAVGGKG IAPASPMLGN ASNPNKADIP 
ERKKSSTVPS SNTASGGMTR RNTYVCSERT TADRHSVIQN GKENSTIPDQ RTPVASTHSI 
SSAATPDRIR FPRGTASRST FHGQPRERRT ATYNGPPASP SLSHEATPLS QTRSRGSTNL 
FSKLTSKLTR RNMSFRFIKR LPTEYERNGR YEGSSRNVSA EQKDENKEAK PRSLRFTWSM 
KTTSSMDPGD MMREIRKVLD ANNCDYEQRE RFLLFCVHGD GHAENLVQWE MEVCKLPRLS 
LNGVRFKRIS GTSIAFKNIA SKIANELKL

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.