Details for: FRYL

Gene ID: 285527

Gene Type:  Protein-coding  - A gene that serves as a template for producing a messenger RNA (mRNA) molecule, which is then translated into a functional protein.

Symbol: FRYL

Ensembl ID: ENSG00000075539

Description: FRY like transcription coactivator

Selected Context(s):  Overall

Cell Significance Landscape

Contexts:

Associated with

Significant Cells

Cell Significance Index (CSI) scores for the chosen context(s)

  • cerebral cortex endothelial cell CL1001602
    CSI 52.7
    rCSI 91.15%
    PRS 14.45
  • pvalb GABAergic cortical interneuron CL4023018
    CSI 51.15
    rCSI 63.63%
    PRS 10.41
  • sncg GABAergic cortical interneuron CL4023015
    CSI 45
    rCSI 72.37%
    PRS 12.14
  • lamp5 GABAergic cortical interneuron CL4023011
    CSI 43.25
    rCSI 72.6%
    PRS 11.18
  • BEST4+ enteroycte CL4030026
    CSI 42.66
    rCSI 53.06%
    PRS 20.14
  • caudal ganglionic eminence derived cortical interneuron CL4023064
    CSI 40.45
    rCSI 71.43%
    PRS 11.14
  • VIP GABAergic cortical interneuron CL4023016
    CSI 36.78
    rCSI 43.94%
    PRS 10.97
  • small intestine goblet cell CL1000495
    CSI 35.75
    rCSI 78.31%
    PRS 25.37
  • oligodendrocyte CL0000128
    CSI 34.17
    rCSI 100%
    PRS 17.56
  • sst GABAergic cortical interneuron CL4023017
    CSI 31.58
    rCSI 40.71%
    PRS 11.71
  • L2/3-6 intratelencephalic projecting glutamatergic neuron CL4023040
    CSI 26.55
    rCSI 64.51%
    PRS 10.96
  • neuroblast (sensu Nematoda and Protostomia) CL0000338
    CSI 25.95
    rCSI 29.97%
    PRS 16.59
  • colon goblet cell CL0009039
    CSI 23.28
    rCSI 55.34%
    PRS 28.35
  • chandelier pvalb GABAergic cortical interneuron CL4023036
    CSI 22.73
    rCSI 71.1%
    PRS 12.84
  • S cone cell CL0003050
    CSI 20.27
    rCSI 89.08%
    PRS 16.54
  • lung secretory cell CL1000272
    CSI 20.01
    rCSI 49.52%
    PRS 17.51
  • intestine goblet cell CL0019031
    CSI 19.09
    rCSI 16.94%
    PRS 19.09
  • L6b glutamatergic cortical neuron CL4023038
    CSI 18.65
    rCSI 58.29%
    PRS 11.92
  • near-projecting glutamatergic cortical neuron CL4023012
    CSI 17.08
    rCSI 64.56%
    PRS 11.48
  • retinal cone cell CL0000573
    CSI 16.29
    rCSI 26.21%
    PRS 14.53
  • conjunctival epithelial cell CL1000432
    CSI 16.27
    rCSI 24.85%
    PRS 19.08
  • paneth cell of epithelium of small intestine CL1000343
    CSI 15.94
    rCSI 44.68%
    PRS 29.32
  • enteroendocrine cell of small intestine CL0009006
    CSI 15.1
    rCSI 33.24%
    PRS 28.77
  • retinal rod cell CL0000604
    CSI 14.67
    rCSI 25.86%
    PRS 18.64
  • kidney loop of Henle thin ascending limb epithelial cell CL1001107
    CSI 14.11
    rCSI 36.49%
    PRS 17.67
  • L5 extratelencephalic projecting glutamatergic cortical neuron CL4023041
    CSI 13.39
    rCSI 48.18%
    PRS 10.5
  • H2 horizontal cell CL0004218
    CSI 12.96
    rCSI 64.44%
    PRS 20.5
  • corticothalamic-projecting glutamatergic cortical neuron CL4023013
    CSI 12.7
    rCSI 74.76%
    PRS 11.71
  • mural cell CL0008034
    CSI 12.46
    rCSI 42.22%
    PRS 19.41
  • retinal ganglion cell CL0000740
    CSI 12.26
    rCSI 27.08%
    PRS 13.58
  • cardiac endothelial cell CL0010008
    CSI 11.54
    rCSI 46.54%
    PRS 17.13
  • renal alpha-intercalated cell CL0005011
    CSI 11.27
    rCSI 15.07%
    PRS 24.71
  • diffuse bipolar 3a cell CL4033029
    CSI 11.04
    rCSI 75.12%
    PRS 19.81
  • GABAergic amacrine cell CL4030027
    CSI 11.01
    rCSI 37.72%
    PRS 16.38
  • intestinal crypt stem cell of colon CL0009043
    CSI 10.01
    rCSI 75.2%
    PRS 34.42
  • blood vessel endothelial cell CL0000071
    CSI 9.89
    rCSI 20.51%
    PRS 18.89
  • intestinal crypt stem cell of small intestine CL0009017
    CSI 9.86
    rCSI 26.59%
    PRS 24.54
  • cardiac blood vessel endothelial cell CL0010006
    CSI 9.2
    rCSI 65.06%
    PRS 21.41
  • central nervous system neuron CL2000029
    CSI 8.74
    rCSI 64.25%
    PRS 10.93
  • L5/6 near-projecting glutamatergic neuron CL4030067
    CSI 8.69
    rCSI 28.57%
    PRS 11.63
  • endothelial cell of vascular tree CL0002139
    CSI 8.58
    rCSI 46.88%
    PRS 29.97
  • Kupffer cell CL0000091
    CSI 7.36
    rCSI 16.84%
    PRS 18.43
  • neuron CL0000540
    CSI 7.17
    rCSI 19.09%
    PRS 15.84
  • endothelial cell of placenta CL0009092
    CSI 6.85
    rCSI 33.78%
    PRS 25.7
  • renal principal cell CL0005009
    CSI 6.83
    rCSI 17.74%
    PRS 24.44
  • interneuron CL0000099
    CSI 6.79
    rCSI 13.64%
    PRS 14.01
  • goblet cell CL0000160
    CSI 6.74
    rCSI 6.37%
    PRS 19.88
  • diffuse bipolar 1 cell CL4033027
    CSI 6.21
    rCSI 46.7%
    PRS 19.14
  • diffuse bipolar 6 cell CL4033032
    CSI 6.09
    rCSI 32%
    PRS 22.2
  • retinal blood vessel endothelial cell CL0002585
    CSI 6.02
    rCSI 9.61%
    PRS 20.8
  • pancreatic A cell CL0000171
    CSI 5.97
    rCSI 6.26%
    PRS 20.2
  • starburst amacrine cell CL0004232
    CSI 5.97
    rCSI 50.26%
    PRS 20.26
  • brush cell of tracheobronchial tree CL0002075
    CSI 5.96
    rCSI 17.7%
    PRS 26.68
  • eye photoreceptor cell CL0000287
    CSI 5.95
    rCSI 66.98%
    PRS 45.31
  • respiratory suprabasal cell CL4033048
    CSI 5.87
    rCSI 7.53%
    PRS 21.92
  • radial glial cell CL0000681
    CSI 5.84
    rCSI 8.11%
    PRS 19.39
  • epithelial cell of proximal tubule CL0002306
    CSI 5.7
    rCSI 13.91%
    PRS 18.63
  • effector CD8-positive, alpha-beta T cell CL0001050
    CSI 5.61
    rCSI 4.27%
    PRS 25.04
  • neuroblast (sensu Vertebrata) CL0000031
    CSI 5.36
    rCSI 6.88%
    PRS 18.32
  • CD4-positive, alpha-beta thymocyte CL0000810
    CSI 5.34
    rCSI 4.28%
    PRS 33.83
  • pro-B cell CL0000826
    CSI 5.19
    rCSI 4.3%
    PRS 19.21
  • glioblast CL0000030
    CSI 5.17
    rCSI 8.24%
    PRS 16.23
  • glycinergic amacrine cell CL4030028
    CSI 5.09
    rCSI 13.26%
    PRS 18.91
  • H1 horizontal cell CL0004217
    CSI 5.07
    rCSI 20.07%
    PRS 25.82
  • colon macrophage CL0009038
    CSI 5.04
    rCSI 23.3%
    PRS 39.09
  • cardiac muscle cell CL0000746
    CSI 5.03
    rCSI 7.22%
    PRS 14.65
  • transit amplifying cell CL0009010
    CSI 4.98
    rCSI 7.61%
    PRS 30.61
  • kidney connecting tubule epithelial cell CL1000768
    CSI 4.96
    rCSI 12.57%
    PRS 14.37
  • naive thymus-derived CD8-positive, alpha-beta T cell CL0000900
    CSI 4.55
    rCSI 3.19%
    PRS 44.59
  • hematopoietic precursor cell CL0008001
    CSI 4.49
    rCSI 4.62%
    PRS 30.72
  • kidney loop of Henle thin descending limb epithelial cell CL1001111
    CSI 4.47
    rCSI 6.34%
    PRS 17.59
  • respiratory basal cell CL0002633
    CSI 4.41
    rCSI 4.57%
    PRS 22.31
  • adipocyte CL0000136
    CSI 4.37
    rCSI 5.61%
    PRS 18.4
  • vascular leptomeningeal cell CL4023051
    CSI 4.34
    rCSI 7.62%
    PRS 14.31
  • differentiation-committed oligodendrocyte precursor CL4023059
    CSI 4.28
    rCSI 7.78%
    PRS 15.78
  • retinal pigment epithelial cell CL0002586
    CSI 4.28
    rCSI 8.49%
    PRS 19.94
  • naive B cell CL0000788
    CSI 4.26
    rCSI 3.65%
    PRS 31.25
  • activated type II NK T cell CL0000931
    CSI 3.96
    rCSI 4.46%
    PRS 30.21
  • renal beta-intercalated cell CL0002201
    CSI 3.96
    rCSI 9.44%
    PRS 21.89
  • interstitial cell of Cajal CL0002088
    CSI 3.89
    rCSI 4.95%
    PRS 22
  • neural cell CL0002319
    CSI 3.88
    rCSI 14.66%
    PRS 25.72
  • mature T cell CL0002419
    CSI 3.78
    rCSI 2.94%
    PRS 27.79
  • hepatic stellate cell CL0000632
    CSI 3.75
    rCSI 14.04%
    PRS 16.01
  • oligodendrocyte precursor cell CL0002453
    CSI 3.73
    rCSI 8.21%
    PRS 15.34
  • alveolar macrophage CL0000583
    CSI 3.64
    rCSI 6%
    PRS 22.38
  • blood vessel smooth muscle cell CL0019018
    CSI 3.56
    rCSI 28.96%
    PRS 19.16
  • unswitched memory B cell CL0000970
    CSI 3.56
    rCSI 2.99%
    PRS 30.06
  • CD16-positive, CD56-dim natural killer cell, human CL0000939
    CSI 3.55
    rCSI 2.36%
    PRS 45.65
  • endocardial cell CL0002350
    CSI 3.48
    rCSI 16.65%
    PRS 23.38
  • direct pathway medium spiny neuron CL4023026
    CSI 3.48
    rCSI 83.25%
    PRS 9.53
  • erythrocyte CL0000232
    CSI 3.47
    rCSI 7.87%
    PRS 25.7
  • L2/3 intratelencephalic projecting glutamatergic neuron CL4030059
    CSI 3.45
    rCSI 7.48%
    PRS 12.75
  • indirect pathway medium spiny neuron CL4023029
    CSI 3.45
    rCSI 83.23%
    PRS 10.46
  • naive T cell CL0000898
    CSI 3.44
    rCSI 2.4%
    PRS 26.87
  • pulmonary capillary endothelial cell CL4028001
    CSI 3.44
    rCSI 6.56%
    PRS 29.99
  • ON midget ganglion cell CL4033046
    CSI 3.43
    rCSI 69.89%
    PRS 15.08
  • GABAergic interneuron CL0011005
    CSI 3.42
    rCSI 53.96%
    PRS 15.88
  • CD14-low, CD16-positive monocyte CL0002396
    CSI 3.4
    rCSI 2.62%
    PRS 17.53
  • corneal epithelial cell CL0000575
    CSI 3.4
    rCSI 9.72%
    PRS 33.28
  • OFF midget ganglion cell CL4033047
    CSI 3.35
    rCSI 68.2%
    PRS 16.11
  • fallopian tube secretory epithelial cell CL4030006
    CSI -3.7
    rCSI -3.5%
    PRS 19.6%
  • forebrain radial glial cell CL0013000
    CSI -1.8
    rCSI -5.7%
    PRS 27.3%
  • inflammatory macrophage CL0000863
    CSI -1.7
    rCSI -2.9%
    PRS 38.0%
  • effector CD4-positive, alpha-beta T cell CL0001044
    CSI -1.2
    rCSI -3.5%
    PRS 28.1%
  • promyelocyte CL0000836
    CSI -1.2
    rCSI -1.7%
    PRS 26.5%
  • fraction A pre-pro B cell CL0002045
    CSI -1.1
    rCSI -1.3%
    PRS 38.2%
  • ciliated columnar cell of tracheobronchial tree CL0002145
    CSI -1.0
    rCSI -2.3%
    PRS 19.6%
  • lung macrophage CL1001603
    CSI -0.7
    rCSI -1.5%
    PRS 22.0%
  • luminal cell of prostate epithelium CL0002340
    CSI -0.5
    rCSI -2.7%
    PRS 33.5%
  • regular ventricular cardiac myocyte CL0002131
    CSI -0.2
    rCSI -1.1%
    PRS 14.8%
  • myeloid lineage restricted progenitor cell CL0000839
    CSI -0.1
    rCSI -0.6%
    PRS 36.7%
  • dopaminergic neuron CL0000700
    CSI 0.0
    rCSI 0.0%
    PRS 10.1%
  • lung microvascular endothelial cell CL2000016
    CSI 0.1
    rCSI 2.3%
    PRS 52.4%
  • cytotoxic T cell CL0000910
    CSI 0.1
    rCSI 0.7%
    PRS 27.8%
  • vein endothelial cell of respiratory system CL4033008
    CSI 0.1
    rCSI 0.8%
    PRS 36.6%
  • eosinophil CL0000771
    CSI 0.2
    rCSI 1.1%
    PRS 47.3%
  • paneth cell of colon CL0009009
    CSI 0.2
    rCSI 1.8%
    PRS 48.8%
  • kidney distal convoluted tubule epithelial cell CL1000849
    CSI 0.2
    rCSI 2.0%
    PRS 24.9%
  • enterocyte of epithelium of small intestine CL1000334
    CSI 0.2
    rCSI 3.3%
    PRS 45.4%
  • podocyte CL0000653
    CSI 0.2
    rCSI 1.0%
    PRS 18.6%
  • granulocyte monocyte progenitor cell CL0000557
    CSI 0.3
    rCSI 0.2%
    PRS 21.3%
  • acinar cell CL0000622
    CSI 0.3
    rCSI 0.4%
    PRS 24.9%
  • endothelial cell of arteriole CL1000412
    CSI 0.3
    rCSI 1.7%
    PRS 49.6%
  • stromal cell CL0000499
    CSI 0.4
    rCSI 1.0%
    PRS 25.6%
  • luminal epithelial cell of mammary gland CL0002326
    CSI 0.4
    rCSI 0.7%
    PRS 28.9%
  • microcirculation associated smooth muscle cell CL0008035
    CSI 0.4
    rCSI 1.1%
    PRS 21.4%
  • endothelial cell of uterus CL0009095
    CSI 0.4
    rCSI 2.8%
    PRS 49.3%
  • group 3 innate lymphoid cell CL0001071
    CSI 0.4
    rCSI 0.3%
    PRS 20.1%
  • central memory CD8-positive, alpha-beta T cell CL0000907
    CSI 0.4
    rCSI 0.3%
    PRS 23.2%
  • kidney loop of Henle thick ascending limb epithelial cell CL1001106
    CSI 0.4
    rCSI 3.8%
    PRS 29.9%
  • type EC enteroendocrine cell CL0000577
    CSI 0.4
    rCSI 1.6%
    PRS 30.8%
  • IgG plasma cell CL0000985
    CSI 0.5
    rCSI 0.6%
    PRS 32.8%
  • enteric smooth muscle cell CL0002504
    CSI 0.5
    rCSI 0.7%
    PRS 21.3%
  • squamous epithelial cell CL0000076
    CSI 0.5
    rCSI 1.1%
    PRS 23.4%
  • pancreatic acinar cell CL0002064
    CSI 0.5
    rCSI 0.6%
    PRS 20.8%
  • primitive red blood cell CL0002355
    CSI 0.5
    rCSI 2.6%
    PRS 33.2%
  • placental villous trophoblast CL2000060
    CSI 0.5
    rCSI 0.8%
    PRS 17.8%
  • enteroendocrine cell of colon CL0009042
    CSI 0.5
    rCSI 2.4%
    PRS 46.8%
  • T-helper 17 cell CL0000899
    CSI 0.5
    rCSI 0.4%
    PRS 33.5%
  • lung ciliated cell CL1000271
    CSI 0.5
    rCSI 0.6%
    PRS 13.9%
  • mature B cell CL0000785
    CSI 0.6
    rCSI 0.5%
    PRS 23.7%
  • enteroglial cell CL4040002
    CSI 0.6
    rCSI 3.0%
    PRS 32.3%
  • vasa recta ascending limb cell CL1001131
    CSI 0.6
    rCSI 2.6%
    PRS 57.1%
  • paneth cell CL0000510
    CSI 0.6
    rCSI 0.9%
    PRS 29.6%
  • lymphoid lineage restricted progenitor cell CL0000838
    CSI 0.6
    rCSI 2.4%
    PRS 31.2%
  • diffuse bipolar 4 cell CL4033031
    CSI 0.6
    rCSI 7.0%
    PRS 21.9%
  • myelocyte CL0002193
    CSI 0.6
    rCSI 4.0%
    PRS 55.2%
  • alpha-beta T cell CL0000789
    CSI 0.6
    rCSI 0.7%
    PRS 26.0%
  • Bergmann glial cell CL0000644
    CSI 0.6
    rCSI 0.9%
    PRS 18.8%
  • promonocyte CL0000559
    CSI 0.7
    rCSI 1.1%
    PRS 25.7%
  • brush cell CL0002204
    CSI 0.7
    rCSI 1.3%
    PRS 45.7%
  • collagen secreting cell CL0000667
    CSI 0.7
    rCSI 3.9%
    PRS 55.3%
  • pancreatic ductal cell CL0002079
    CSI 0.7
    rCSI 1.3%
    PRS 19.4%
  • OFF-bipolar cell CL0000750
    CSI 0.7
    rCSI 1.0%
    PRS 29.7%
  • endothelial cell of venule CL1000414
    CSI 0.7
    rCSI 6.3%
    PRS 61.1%
  • intestinal tuft cell CL0019032
    CSI 0.7
    rCSI 1.1%
    PRS 21.7%
  • natural T-regulatory cell CL0000903
    CSI 0.8
    rCSI 1.4%
    PRS 49.6%
  • CD4-positive helper T cell CL0000492
    CSI 0.8
    rCSI 0.6%
    PRS 26.0%
  • cerebral cortex pyramidal neuron CL4023111
    CSI 0.8
    rCSI 4.6%
    PRS 46.7%
  • duct epithelial cell CL0000068
    CSI 0.8
    rCSI 1.1%
    PRS 20.1%
  • mature alpha-beta T cell CL0000791
    CSI 0.8
    rCSI 2.7%
    PRS 32.5%
  • alveolar adventitial fibroblast CL4028006
    CSI 0.8
    rCSI 1.2%
    PRS 19.1%
  • multi-ciliated epithelial cell CL0005012
    CSI 0.8
    rCSI 0.8%
    PRS 16.2%
  • central memory CD4-positive, alpha-beta T cell CL0000904
    CSI 0.8
    rCSI 0.5%
    PRS 26.5%
  • transitional stage B cell CL0000818
    CSI 0.8
    rCSI 2.5%
    PRS 49.3%
  • large pre-B-II cell CL0000957
    CSI 0.8
    rCSI 2.3%
    PRS 32.2%
  • medium spiny neuron CL1001474
    CSI 0.8
    rCSI 7.0%
    PRS 9.1%
  • CD8-positive, alpha-beta cytotoxic T cell CL0000794
    CSI 0.8
    rCSI 1.0%
    PRS 33.1%
  • CD8-positive, CD28-negative, alpha-beta regulatory T cell CL0000920
    CSI 0.8
    rCSI 1.6%
    PRS 31.6%
  • lung endothelial cell CL1001567
    CSI 0.8
    rCSI 1.9%
    PRS 43.4%
  • glandular epithelial cell CL0000150
    CSI 0.8
    rCSI 2.2%
    PRS 36.7%
  • type B pancreatic cell CL0000169
    CSI 0.9
    rCSI 1.9%
    PRS 17.5%
  • brain vascular cell CL4023072
    CSI 0.9
    rCSI 8.9%
    PRS 21.8%
  • macroglial cell CL0000126
    CSI 0.9
    rCSI 2.2%
    PRS 24.8%
  • tendon cell CL0000388
    CSI 0.9
    rCSI 2.3%
    PRS 47.5%
  • memory T cell CL0000813
    CSI 0.9
    rCSI 1.7%
    PRS 42.4%
  • serotonergic neuron CL0000850
    CSI 0.9
    rCSI 4.0%
    PRS 11.3%
  • mucus secreting cell CL0000319
    CSI 0.9
    rCSI 1.4%
    PRS 24.4%
  • elicited macrophage CL0000861
    CSI 0.9
    rCSI 0.8%
    PRS 22.2%
  • contractile cell CL0000183
    CSI 1.0
    rCSI 2.9%
    PRS 17.8%
  • mesodermal cell CL0000222
    CSI 1.0
    rCSI 1.2%
    PRS 18.5%
  • granulocyte CL0000094
    CSI 1.0
    rCSI 1.5%
    PRS 24.4%
  • common myeloid progenitor CL0000049
    CSI 1.0
    rCSI 0.8%
    PRS 19.0%
  • tuft cell of colon CL0009041
    CSI 1.1
    rCSI 2.5%
    PRS 37.6%
  • double negative thymocyte CL0002489
    CSI 1.1
    rCSI 0.8%
    PRS 22.6%
  • glutamatergic neuron CL0000679
    CSI 1.1
    rCSI 2.2%
    PRS 18.8%
  • colonocyte CL1000347
    CSI 1.1
    rCSI 1.6%
    PRS 25.7%
  • GABAergic neuron CL0000617
    CSI 1.1
    rCSI 3.7%
    PRS 13.4%
  • transit amplifying cell of colon CL0009011
    CSI 1.1
    rCSI 1.3%
    PRS 22.0%
  • CD1c-positive myeloid dendritic cell CL0002399
    CSI 1.1
    rCSI 1.3%
    PRS 22.7%
  • foveolar cell of stomach CL0002179
    CSI 1.1
    rCSI 2.4%
    PRS 30.2%
  • common lymphoid progenitor CL0000051
    CSI 1.2
    rCSI 1.5%
    PRS 36.0%
  • pulmonary ionocyte CL0017000
    CSI 1.2
    rCSI 1.4%
    PRS 23.8%
  • double-positive, alpha-beta thymocyte CL0000809
    CSI 1.2
    rCSI 1.2%
    PRS 27.1%
  • skeletal muscle satellite cell CL0000594
    CSI 1.2
    rCSI 3.5%
    PRS 54.3%
  • L4 intratelencephalic projecting glutamatergic neuron CL4030063
    CSI 1.2
    rCSI 2.9%
    PRS 12.0%
  • M cell of gut CL0000682
    CSI 1.2
    rCSI 1.3%
    PRS 32.6%
  • neuroplacodal cell CL0000032
    CSI 1.2
    rCSI 11.4%
    PRS 49.1%
  • basal cell CL0000646
    CSI 1.3
    rCSI 1.7%
    PRS 20.8%
  • centrilobular region hepatocyte CL0019029
    CSI 1.3
    rCSI 3.4%
    PRS 29.0%

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Network Configuration

Explore relationships of the current gene. Select an Interaction Source: 'ONTOLOGY' for shared pathways (GO/Reactome) or 'STRING' for protein-protein interactions. Further refine by selecting context genes and comparing Cell Significance Index (CSI) scores between baseline and target cell types and their specific contexts.

Comma-separated if multiple.
Comma-separated if multiple.

Legend:
  • Query Gene
  • Node Color (Target Cell CSI, relative to current network):
    • Very High
    • High
    • Medium
    • Low
    • Very Low
    • CSI N/A
  • Node Size: Proportional to Target Cell CSI magnitude
  • STRING PPI Edge
  • Shared Pathway Edge (ONTOLOGY)

Loading network (please wait)...

Other Information

This section provides additional information about the gene, including a description generated by an AI language model and details about associated proteins.

## Summary [FRYL](/details-gene/285527), or FRY like transcription coactivator, is a protein-coding gene located on chromosome 4. Functional annotations suggest its involvement in fundamental cellular processes such as [cell morphogenesis](/details-go/GO:0000902) and [neuron projection development](/details-go/GO:0031175), primarily through [protein binding](/details-go/GO:0005515) interactions at the [cell cortex](/details-go/GO:0005938). **Overall**, expression data reveals a highly specific enrichment of [FRYL](/details-gene/285527) in the central nervous system, where it is a significant marker for [cerebral cortex endothelial cells](/details-cell/CL1001602) and a diverse array of neuronal subtypes, particularly GABAergic cortical interneurons. It also shows notable expression in specialized epithelial cells of the intestine, such as [BEST4+ enteroyctes](/details-cell/CL4030026) and [goblet cells](/details-cell/CL1000495). ## Cellular Roles and Expression Landscape The expression profile of [FRYL](/details-gene/285527) highlights its specialized role within the nervous and gastrointestinal systems. The gene shows its highest significance in [cerebral cortex endothelial cells](/details-cell/CL1001602) (CSI: 52.70), suggesting a key function in the vasculature of the brain. It is also a prominent marker across numerous neuronal populations, with high CSI scores in multiple GABAergic cortical interneuron subtypes, including [pvalb](/details-cell/CL4023018), [sncg](/details-cell/CL4023015), and [lamp5](/details-cell/CL4023011), as well as in [oligodendrocytes](/details-cell/CL0000128) and glutamatergic neurons. This broad yet specific expression pattern within the CNS points towards a critical role in neural development, connectivity, and maintenance. Beyond the brain, [FRYL](/details-gene/285527) is significantly expressed in the intestinal epithelium, specifically in [BEST4+ enteroyctes](/details-cell/CL4030026), [small intestine goblet cells](/details-cell/CL1000495), and [colon goblet cells](/details-cell/CL0009039). This suggests a parallel function in the morphogenesis and polarized activity of these secretory cell types. Conversely, the gene's specificity is underscored by its negligible expression in hematopoietic and immune lineages, including [inflammatory macrophages](/details-cell/CL0000863) and [effector CD4-positive, alpha-beta T cells](/details-cell/CL0001044). It is also notably absent from various other epithelial and mesenchymal cells, such as [fallopian tube secretory epithelial cells](/details-cell/CL4030006) and [cardiac myocytes](/details-cell/CL0002131), reinforcing its specialized role. ## Pathways and Molecular Function The functional annotations for [FRYL](/details-gene/285527) align closely with its observed cellular expression pattern. Its role in [neuron projection development](/details-go/GO:0031175) is highly consistent with its strong expression across a wide range of developing and mature neurons. This process is fundamentally dependent on precise control of cell shape and growth, which corresponds to its localization at the [cell cortex](/details-go/GO:0005938) and the [site of polarized growth](/details-go/GO:0030427). These functions are also relevant to its expression in highly polarized intestinal epithelial cells, which require strict morphological control to maintain barrier function and directed secretion. Although described as a transcription coactivator, its primary annotated molecular function is general [protein binding](/details-go/GO:0005515), suggesting it acts as a scaffold or adaptor protein to mediate these morphogenic processes. While its expression is low in hematopoietic cells, it has been identified as a fusion partner for MLL in leukemia, indicating a potential for oncogenic activity when its expression is deregulated ([Link](https://doi.org/10.1158/0008-5472.can-05-1325)). ## Research Directions The specific expression pattern and functional annotation of [FRYL](/details-gene/285527) suggest several avenues for future research. **Proposed Hypotheses:** 1. Given its top expression in [cerebral cortex endothelial cells](/details-cell/CL1001602) and its role in [cell morphogenesis](/details-go/GO:0000902), we hypothesize that **[FRYL](/details-gene/285527) is a critical regulator of cellular architecture and tight junction integrity in the blood-brain barrier (BBB).** 2. Based on its strong and widespread expression in cortical interneurons and its link to [neuron projection development](/details-go/GO:0031175), we hypothesize that **[FRYL](/details-gene/285527) orchestrates the proper arborization and synaptic targeting of interneurons during cortical circuit formation.** Dysregulation of this gene could contribute to neurodevelopmental disorders associated with excitatory/inhibitory imbalance. 3. The identification of [FRYL](/details-gene/285527) as an MLL fusion partner in leukemia ([Link](https://doi.org/10.1158/0008-5472.can-05-1325)), despite its low expression in normal hematopoietic cells, suggests that **the MLL-FRYL fusion protein ectopically activates neuro-morphogenic pathways in hematopoietic progenitors, thereby blocking differentiation and promoting leukemogenesis.** **Experimental Approach:** To test the first hypothesis regarding the role of [FRYL](/details-gene/285527) in BBB integrity, an *in vitro* model using human brain microvascular endothelial cells (hBMECs) could be employed. [FRYL](/details-gene/285527) expression could be silenced using CRISPRi or shRNA in hBMECs cultured on Transwell inserts. The functional consequence would be assessed by measuring changes in transendothelial electrical resistance (TEER) and paracellular flux of fluorescently-labeled dextrans. Furthermore, immunofluorescence microscopy for key tight junction proteins (e.g., ZO-1, Claudin-5) would reveal any disruptions in their localization and continuity at cell-cell junctions. **Therapeutic Potential:** The therapeutic potential of targeting [FRYL](/details-gene/285527) is highly context-dependent. Its high expression in diverse and critical cell types within the central nervous system suggests that systemic inhibition could lead to significant neurological toxicity. However, in the specific context of leukemia driven by an MLL-FRYL fusion, the fusion protein itself presents a highly specific tumor antigen. Strategies aimed at inhibiting the fusion-specific protein-protein interactions or targeting the fusion protein for degradation would represent a promising therapeutic avenue. In this malignancy, inhibition of the fusion product's activity would be the desired therapeutic strategy.

Genular Protein ID: 3552647657

Symbol: FRYL_HUMAN

Name: Protein furry homolog-like

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 15815621

Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.

PubMed ID: 15815621

DOI: 10.1038/nature03466

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 10048485

Title: Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.

PubMed ID: 10048485

DOI: 10.1093/dnares/5.6.355

PubMed ID: 17974005

Title: The full-ORF clone resource of the German cDNA consortium.

PubMed ID: 17974005

DOI: 10.1186/1471-2164-8-399

PubMed ID: 16061630

Title: AF4p12, a human homologue to the furry gene of Drosophila, as a novel MLL fusion partner.

PubMed ID: 16061630

DOI: 10.1158/0008-5472.can-05-1325

PubMed ID: 16964243

Title: A probability-based approach for high-throughput protein phosphorylation analysis and site localization.

PubMed ID: 16964243

DOI: 10.1038/nbt1240

PubMed ID: 18691976

Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.

PubMed ID: 18691976

DOI: 10.1016/j.molcel.2008.07.007

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 21835304

Title: Exome sequencing and cis-regulatory mapping identify mutations in MAK, a gene encoding a regulator of ciliary length, as a cause of retinitis pigmentosa.

PubMed ID: 21835304

DOI: 10.1016/j.ajhg.2011.07.005

Sequence Information:

  • Length: 3013
  • Mass: 339598
  • Checksum: DFD7FEC47792DA1E
  • Sequence:
  • MSNITIDPDV KPGEYVIKSL FAEFAVQAEK KIEVVMAEPL EKLLSRSLQR GEDLQFDQLI 
    SSMSSVAEHC LPSLLRTLFD WYRRQNGTED ESYEYRPRSS TKSKGDEQQR ERDYLLERRD 
    LAVDFIFCLV LVEVLKQIPV HPVPDPLVHE VLNLAFKHFK HKEGYSGTNT GNVHIIADLY 
    AEVIGVLAQS KFQAVRKKFV TELKELRQKE QSPHVVQSVI SLIMGMKFFR VKMYPVEDFE 
    ASFQFMQECA QYFLEVKDKD IKHALAGLFV EILIPVAAAV KNEVNVPCLK NFVEMLYQTT 
    FELSSRKKHS LALYPLITCL LCVSQKQFFL NNWHIFLQNC LSHLKNKDPK MSRVALESLY 
    RLLWVYVIRI KCESNTVTQS RLMSIVSALF PKGSRSVVPR DTPLNIFVKI IQFIAQERLD 
    FAMKEIIFDL LSVGKSTKTF TINPERMNIG LRVFLVIADS LQQKDGEPPM PTTGVILPSG 
    NTLRVKKIFL NKTLTDEEAK VIGMSVYYPQ VRKALDSILR HLDKEVGRPM CMTSVQMSNK 
    EPEDMITGER KPKIDLFRTC IAAIPRLIPD GMSRTDLIEL LARLTIHMDE ELRALAFNTL 
    QALMLDFPDW REDVLSGFVY FIVREVTDVH PTLLDNAVKM LVQLINQWKQ AAQMHNKNQD 
    TQHGVANGAS HPPPLERSPY SNVFHVVEGF ALVILCSSRP ATRRLAVSVL REIRALFALL 
    EIPKGDDELA IDVMDRLSPS ILESFIHLTG ADQTTLLYCP SSIDLQTLAE WNSSPISHQF 
    DVISPSHIWI FAHVTQGQDP WIISLSSFLK QENLPKHCST AVSYAWMFAY TRLQLLSPQV 
    DINSPINAKK VNTTTSSDSY IGLWRNYLIL CCSAATSSSS TSAGSVRCSP PETLASTPDS 
    GYSIDSKIIG IPSPSSLFKH IVPMMRSESM EITESLVLGL GRTNPGAFRE LIEELHPIIK 
    EALERRPENM KRRRRRDILR VQLVRIFELL ADAGVISHSA SGGLDNETHF LNNTLLEYVD 
    LTRQLLEAEN EKDSDTLKDI RCHFSALVAN IIQNVPVHQR RSIFPQQSLR HSLFMLFSHW 
    AGPFSIMFTP LDRYSDRNMQ INRHQYCALK AMSAVLCCGP VADNVGLSSD GYLYKWLDNI 
    LDSLDKKVHQ LGCEAVTLLL ELNPDQSNLM YWAVDRCYTG SGRVAAGCFK AIANVFQNRD 
    YQCDTVMLLN LILFKAADSS RSIYEVAMQL LQILEPKMFR YAHKLEVQRT DGVLSQLSPL 
    PHLYSVSYYQ LSEELARAYP ELTLAIFSEI SQRIQTAHPA GRQVMLHYLL PWMNNIELVD 
    LKPLPTARRH DEDEDDSLKD RELMVTSRRW LRGEGWGSPQ ATAMVLNNLM YMTAKYGDEL 
    AWSEVENVWT TLADGWPKNL KIILHFLISI CGVNSEPSLL PYVKKVIVYL GRDKTMQLLE 
    ELVSELQLTD PVSSGVTHMD NPPYYRITSS YKIPSVTSGT TSSSNTMVAP TDGNPDNKPI 
    KENIEESYVH LDIYSGLNSH LNRQHHRLES RYSSSSGGSY EEEKSDSMPL YSNWRLKVME 
    HNQGEPLPFP PAGGCWSPLV DYVPETSSPG LPLHRCNIAV ILLTDLIIDH SVKVEWGSYL 
    HLLLHAIFIG FDHCHPEVYE HCKRLLLHLL IVMGPNSNIR TVASVLLRNK EFNEPRVLTV 
    KQVAHLDYNF TAGINDFIPD YQPSPMTDSG LSSSSTSSSI SLGNNSAAIS HLHTTILNEV 
    DISVEQDGKV KTLMEFITSR KRGPLWNHED VSAKNPSIKS AEQLTTFLKH VVSVFKQSSS 
    EGIHLEHHLS EVALQTALSC SSRHYAGRSF QIFRALKQPL TATTLSDVLS RLVETVGDPG 
    EDAQGFVIEL LLTLESAIDT LAETMKHYDL LSALSQTSYH DPIMGNKYAA NRKSTGQLNL 
    STSPINSSSY LGYNSNARSN SLRLSLIGDR RGDRRRSNTL DIMDGRINHS SSLARTRSLS 
    SLREKGMYDV QSTTEPTNLM ATIFWIAASL LESDYEYEYL LALRLLNKLL IHLPLDKSES 
    REKIENVQSK LKWTNFPGLQ QLFLKGFTSA STQEMTVHLL SKLISVSKHT LVDPSQLSGF 
    PLNILCLLPH LIQHFDSPTQ FCKETASRIA KVCAEEKCPT LVNLAHMMSL YSTHTYSRDC 
    SNWINVVCRY LHDSFSDTTF NLVTYLAELL EKGLSSMQQS LLQIIYSLLS HIDLSAAPAK 
    QFNLEIIKII GKYVQSPYWK EALNILKLVV SRSASLVVPS DIPKTYGGDT GSPEISFTKI 
    FNNVSKELPG KTLDFHFDIS ETPIIGNKYG DQHSAAGRNG KPKVIAVTRS TSSTSSGSNS 
    NALVPVSWKR PQLSQRRTRE KLMNVLSLCG PESGLPKNPS VVFSSNEDLE VGDQQTSLIS 
    TTEDINQEEE VAVEDNSSEQ QFGVFKDFDF LDVELEDAEG ESMDNFNWGV RRRSLDSIDK 
    GDTPSLQEYQ CSSSTPSLNL TNQEDTDESS EEEAALTASQ ILSRTQMLNS DSATDETIPD 
    HPDLLLQSED STGSITTEEV LQIRDETPTL EASLDNANSR LPEDTTSVLK EEHVTTFEDE 
    GSYIIQEQQE SLVCQGILDL EETEMPEPLA PESYPESVCE EDVTLALKEL DERCEEEEAD 
    FSGLSSQDEE EQDGFPEVQT SPLPSPFLSA IIAAFQPVAY DDEEEAWRCH VNQMLSDTDG 
    SSAVFTFHVF SRLFQTIQRK FGEITNEAVS FLGDSLQRIG TKFKSSLEVM MLCSECPTVF 
    VDAETLMSCG LLETLKFGVL ELQEHLDTYN VKREAAEQWL DDCKRTFGAK EDMYRINTDA 
    QQMEILAELE LCRRLYKLHF QLLLLFQAYC KLINQVNTIK NEAEVINMSE ELAQLESILK 
    EAESASENEE IDISKAAQTT IETAIHSLIE TLKNKEFISA VAQVKAFRSL WPSDIFGSCE 
    DDPVQTLLHI YFHHQTLGQT GSFAVIGSNL DMSEANYKLM ELNLEIRESL RMVQSYQLLA 
    QAKPMGNMVS TGF

Genular Protein ID: 3690631104

Symbol: A0A2C9F2R7_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

PubMed ID: 15815621

Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.

PubMed ID: 15815621

DOI: 10.1038/nature03466

PubMed ID: 16964243

Title: A probability-based approach for high-throughput protein phosphorylation analysis and site localization.

PubMed ID: 16964243

DOI: 10.1038/nbt1240

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

Sequence Information:

  • Length: 3007
  • Mass: 338912
  • Checksum: D5F9C3F756491F29
  • Sequence:
  • MSNITIDPDV KPGEYVIKSL FAEFAVQAEK KIEVVMAEPL EKLLSRSLQR GEDLQFDQLI 
    SSMSSVAEHC LPSLLRTLFD WYRRQNGTED ESYEYRPRSS TKSKGDEQQR ERDYLLERRD 
    LAVDFIFCLV LVEVLKQIPV HPVPDPLVHE VLNLAFKHFK HKEGYSGTNT GNVHIIADLY 
    AEVIGVLAQS KFQAVRKKFV TELKELRQKE QSPHVVQSVI SLIMGMKFFR VKMYPVEDFE 
    ASFQFMQECA QYFLEVKDKD IKHALAGLFV EILIPVAAAV KNEVNVPCLK NFVEMLYQTT 
    FELSSRKKHS LALYPLITCL LCVSQKQFFL NNWHIFLQNC LSHLKNKDPK MSRVALESLY 
    RLLWVYVIRI KCESNTVTQS RLMSIVSALF PKGSRSVVPR DTPLNIFVKI IQFIAQERLD 
    FAMKEIIFDL LSVGKSTKTF TINPERMNIG LRVFLVIADS LQQKDGEPPM PTTGVILPSG 
    NTLRVKKIFL NKTLTDEEAK VIGMSVYYPQ VRKALDSILR HLDKEVGRPM CMTSVQMSNK 
    EPEDMITGER KPKIDLFRTC IAAIPRLIPD GMSRTDLIEL LARLTIHMDE ELRALAFNTL 
    QALMLDFPDW REDVLSGFVY FIVREVTDVH PTLLDNAVKM LVQLINQWKQ AAQMHNKNQD 
    TQHGVANGAS HPPPLERSPY SNVFHVVEGF ALVILCSSRP ATRRLAVSVL REIRALFALL 
    EIPKGDDELA IDVMDRLSPS ILESFIHLTG ADQTTLLYCP SSIDLQTLAE WNSSPISHQF 
    DVISPSHIWI FAHVTQGQDP WIISLSSFLK QENLPKHCST AVSYAWMFAY TRLQLLSPQV 
    DINSPINAKK VNTTTSSDSY IGLWRNYLIL CCSAATSSSS TSAGSVRCSP PETLASTPDS 
    GYSIDSKIIG IPSPSSLFKH IVPMMRSESM EITESLVLGL GRTNPGAFRE LIEELHPIIK 
    EALERRPENM KRRRRRDILR VQLVRIFELL ADAGVISHSA SGGLDNETHF LNNTLLEYVD 
    LTRQLLEAEN EKDSDTLKDI RCHFSALVAN IIQNVPVHQR RSIFPQQSLR HSLFMLFSHW 
    AGPFSIMFTP LDRYSDRNMQ INRHQYCALK AMSAVLCCGP VADNVGLSSD GYLYKWLDNI 
    LDSLDKKVHQ LGCEAVTLLL ELNPDQSNLM YWAVDRCYTG SGRVAAGCFK AIANVFQNRD 
    YQCDTVMLLN LILFKAADSS RSIYEVAMQL LQILEPKMFR YAHKLEVQRT DGVLSQLSPL 
    PHLYSVSYYQ LSEELARAYP ELTLAIFSEI SQRIQTAHPA GRQVMLHYLL PWMNNIELVD 
    LKPLPTARRH DEDEDDSLKD RELMVTSRRW LRGEGWGSPQ ATAMVLNNLM YMTAKYGDEL 
    AWSEVENVWT TLADGWPKNL KIILHFLISI CGVNSEPSLL PYVKKVIVYL GRDKTMQLLE 
    ELVSELQLTD PVSSGVTHMD NPPYYRITSS YKIPSVTSGT TSSSNTMVAP TDGNPDNKPI 
    KENIEESYVH LDIYSGLNSH LNRQHHRLES RYSSSSGGSY EEEKSDSMPL YSNWRLKVME 
    HNQGEPLPFP PAGGCWSPLV DYVPETSSPG LPLHRCNIAV ILLTDLIIDH SVKVEWGSYL 
    HLLLHAIFIG FDHCHPEVYE HCKRLLLHLL IVMGPNSNIR TVASVLLRNK EFNEPRVLTV 
    KQVAHLDYNF TAGINDFIPD YQPSPMTDSG LSSSSTSSSI SLGNNSAAIS HLHTTILNEV 
    DISVEQDGKV KTLMEFITSR KRGPLWNHED VSAKNPSIKS AEQLTTFLKH VVSVFKQSSS 
    EGIHLEHHLS EVALQTALSC SSRHYAGRSF QIFRALKQPL TATTLSDVLS RLVETVGDPG 
    EDAQGFVIEL LLTLESAIDT LAETMKHYDL LSALSQTSYH DPIMGNKYAA NRKSTGQLNL 
    STSPINSSSY LGYNSNARSN SLRLSLIGDR RGDRRRSNTL DIMDGRINHS SSLARTRSLS 
    SLREKGMYDV QSTTEPTNLM ATIFWIAASL LESDYEYEYL LALRLLNKLL IHLPLDKSES 
    REKIENVQSK LKWTNFPGLQ QLFLKGFTSA STQEMTVHLL SKLISVSKHT LVDPSQLSGF 
    PLNILCLLPH LIQHFDSPTQ FCKETASRIA KVCAEEKCPT LVNLAHMMSL YSTHTYSRDC 
    SNWINVVCRY LHDSFSDTTF NLVTYLAELL EKGLSSMQQS LLQIIYSLLS HIDLSAAPAK 
    QFNLEIIKII GKYVQSPYWK EALNILKLVV SRSASLVVPS DIPKTYGGDT GSPEISFTKI 
    FNNVSKELPG KTLDFHFDIS ETPIIGNKYG DQHSAAGRNG KPKVIAVTRS TSSTSSGSNS 
    NALVPVSWKR PQLSQRRTRE KLMNVLSLCG PESGLPKNPS VVFSSNEDLE VGDQQTSLIS 
    TTEDINQEEE VAVEDNSSEQ QFGVFKDFDF LDVELEDAEG ESMDNFNWGV RRRSLDSIDK 
    GDTPSLQEYQ CSSSTPSLNL TNQEDTDESS EEEAALTASQ ILSRTQMLNS DSATDETIPD 
    HPDLLLQSED STGSITTEEV LQIRDETPTL EASLDNANSR LPEDTTSVLK EEHVTTFEDE 
    GSYIIQEQQE SLVCQGILDL EETEMPEPLA PESYPESVCE EDVTLALKEL DERCEEEEAD 
    FSGLSSQDEE EQDGFPEVQT SPLPSPFLSA IIAAFQPVAY DDEEEAWRCH VNQMLSDTDG 
    SSAVFTFHVF SRLFQTIQRK FGEITNEAVS FLGDSLQRIG TKFKSSLEVM MLCSECPTVF 
    VDAETLMSCG LLETLKFGVL ELQEHLDTYN VKREAAEQWL DDCKRTFGAK EDMYRINTDA 
    QELELCRRLY KLHFQLLLLF QAYCKLINQV NTIKNEAEVI NMSEELAQLE SILKEAESAS 
    ENEEIDISKA AQTTIETAIH SLIETLKNKE FISAVAQVKA FRSLWPSDIF GSCEDDPVQT 
    LLHIYFHHQT LGQTGSFAVI GSNLDMSEAN YKLMELNLEI RESLRMVQSY QLLAQAKPMG 
    NMVSTGF

Genular Protein ID: 190741259

Symbol: B3KXG5_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Sequence Information:

  • Length: 1455
  • Mass: 162511
  • Checksum: 597FAD6E675884E6
  • Sequence:
  • MEHNQGEPLP FPPTGGCWSP LVDYVPETSS PGLPLHRCNI AVILLTDLII DHSVKVEWGS 
    YLHLLLHAIF IGFDHCHPEV YEHCKRLLLH LLIVMGPNSN IRTVASVLLR NKEFNEPRVL 
    TVKQVAHLDY NFTAGINDFI PDYQPSPMTD SGLSSSSTSS SISLGNNSAA ISHLHTTILN 
    EVDISVEQDG KVKTLMEFIT SRKRGPLWNH EDVSAKNPSI KSAEQLTTFL KHVVSVFKQS 
    SSEGIHLEHH LSEVALQTAL SCSSRHYAGR SFQIFRALKQ PLTATTLSDV LSRLVETVGD 
    PGEDAQGFVI ELLLTLESAI DTLAETMKHY DLLSALSQTS YHDPIMGNKY AANRKSTGQL 
    NLSTSPINSS SYLGYNSNAR SNSLRLSLIG DRRGDRRRSN TLDIMDGRIN HSSSLARTRS 
    LSSLREKGMY DVQSTTEPTN LMATIFWIAA SLLESDYEYE YLLALRLLNK LLIHLPLDKS 
    ESREKIENVQ SKLKWTNFPG LQQLFLKGFT SASTQEMTVH LLSKLISVSK HTLVDPSQLS 
    GFPLNILCLL PHLIQHFDSP TQFCKETASR IAKVCAEEKC PTLVNLAHMM SLYSTHTYSR 
    DCSNWINVVC RYLHDSFSDT TFNLVTYLAE LLEKGLSSMQ QSLLQIIYSL LSHIDLSAAP 
    AKQFNLEIIK IIGKYVQSPY WKEALNILKL VVSRSASLVV PSDIPKTYGG DTGSPEISFT 
    KIFNNVSKEL PGKTLDFHFD ISETPIIGNK YGDQHSAAGR NGKPKVIAVT RSTSSTSSGS 
    NSNALVPVSW KRPQLSQRRT REKLMNVLSL CGPESGLPKN PSVVFSSNED LEVGDQQTSL 
    ISTTEDINQE EEVAVEDNSS EQQFGVFKDF DFLDVELEDA EGESMDNFNW GVRRRSLDSI 
    DKGDTPSLQE YQCSSSTPSL NLTNQEDTDE SSEEEAALTA SQILSRTQML NSDSATDETI 
    PDHPDLLLQS EDSTGSITTE EVLQIRDETP TLEASLDNAN SRLPEDTTSV LKEEHVTTFE 
    DEGSYIIQEQ QESLVCQGIL DLEETEMPEP LAPESYPESV CEEDVTLALK ELDERCEEEE 
    ADFSGLSSQD EEEQDGFPEV QTSPLPSPFL SAIIAAFQPV AYDDEEEAWR CHVNQMLSDT 
    DGSSAVFTFH VFSRLFQTIQ RKFGEITNEA VSFLGDSLQR IGTKFKSSLE VMMLCSECPT 
    VFVDAETLMS CGLLETLKFG VLELQEHLDT YNVKREAAEQ WLDDCKRTFG AKEDMYRINT 
    DAQQMEILAE LELCRRLYKL HFQLLLLFQA YCKLINQVNT IKNEAEVINM SEELAQLESI 
    LKEAESASEN EEIDISKAAQ TTIETAIHSL IETLKNKEFI SAVAQVKAFR SLWPSDIFGS 
    CEDDPVQTLL HIYFHHQTLG QTGSFAVIGS NLDMSEANYK LMELNLEIRE SLRMVQSYQL 
    LAQAKPMGNM VSTGF

Genular Protein ID: 852662714

Symbol: Q6ZR29_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Sequence Information:

  • Length: 1433
  • Mass: 160155
  • Checksum: 4FEC29D52068D644
  • Sequence:
  • MYWAVDRCYT GSGRVAAGCF KAIANVFQNR DYQCDTVMLL NLILFKAADS SRSIYEVAMQ 
    LLQILEPKMF RYAHKLEVQR TDGVLSQLSP LPHLYSVSYY QLSEELARAY PELTLAIFSE 
    ISQRIQTAHP AGRQVMLHYL LPWMNNIELV DLKPLPTARR HDEDEDDSLK DRELMVTSRR 
    WLRGEGWGSP QATAMVLNNL MYMTAKYGDE LAWSEVENVW TTLADGWPKN LKIILHFLIS 
    ICGVNSEPSL LPYVKKVIVY LGRDKTMQLL EELVSELQLT DPVSSGVTHM DNPPYYRITS 
    SYKIPSVTSG TTSSSNTMVA PTDGNPDNKP IKENIEESYV HLDIYSGLNS HLNRQHHRLE 
    SRYSSSSGGS YEEEKSDSMP LYSNWRLKVM EHNQGEPLPF PPAGGCWSPL VDYVPETSSP 
    GLPLHRCNIA VILLTDLIID HSVKVEWGSY LHLLLHAIFI GFDHCHPEVY EHCKRLLLHL 
    LIVMGPNSNI RTVASVLLRN KEFNEPRVLT VKQVAHLDYN FTGINDFIPD YQPSPMTDSG 
    LSSSSTSSSI SLGNNSAAIS HLHTTILNEV DISVEQDGKV KTLMEFITSR KRGPLWNHED 
    VSAKNPSIKS AEQLTTFLKH VVSVFKQSSS EGIHLEHHLS EVALQTALSC SSRHYAGRSF 
    QIFRALKQPL TATTLSDVLS RLVETVGDPG EDAQGFVIEL LLTLESAIDT LAETMKHYDL 
    LSALSQTSYH DPIMGNRYAA NRKSTGQLNL STSPINSSSY LGYNSNARSN SLRLSLIGDR 
    RGDRRRSNTL DIMDGRINHS SSLARTRSLS SLREKGMYDV QSTTEPTNLM ATIFWIAASL 
    LESDYEYEYL LALRLLNKLL IHLPLDKSES REKIENVQSK LKWTNFPGLQ QLFLKGFTSA 
    STQEMTVHLL SKLISVSKHT LVDPSQLSGF PLNILCLLPH LIQHFDSPTQ FCKETASRIA 
    KVCAEEKCPT LVNLAHMMSL YSTHTYSRDC SNWINVVCRY LHDSFSDTTF NLVTYLAELL 
    EKGLSSMQQS LLQIIYSLLS HIDLSAAPAK QFNLEIIKII GKYVQSPYWK EALNILKLVV 
    SRSASLVVPS DIPKTYGGDT GSPEISFTKI FNNVSKELPG KTLDFHFDIS ETPIIGNKYG 
    DQHSAAGRNG KPKVIAVTRS TSSTSSGSNS NALVPVSWKR PQLSQRRTRE KLMNVLSLCG 
    PESGLPKNPS VVFSSNEDLE VGDQQTSLIS TTEDINQEEE VAVEDNSSEQ QFGVFKDFDF 
    LDVELEDAEG ESMDNFNWGV RRRSLDSIDK GDTPSLQEYQ CSSSTPSLNL TNQEDTDESS 
    EEEAALTASQ ILSRTQMLNS DSATDETIPD HPDLLLQSED STGSITTEEV LQIRDETPTL 
    EASLDNANSR LPEDTTSVLK EEHVTTFEDE GSYIILPEGQ TSKTSPGATT LVI