Gene TUBA1A - ENSG00000167552 | NCBI Gene ID: 7846

Details for: TUBA1A

Gene ID: 7846

Symbol: TUBA1A

Ensembl ID: ENSG00000167552

Description: tubulin alpha 1a

Associated with

Activation of ampk downstream of nmdars
(R-HSA-9619483)
Activation of nmda receptors and postsynaptic events
(R-HSA-442755)
Adaptive immune system
(R-HSA-1280218)
Aggrephagy
(R-HSA-9646399)
Anchoring of the basal body to the plasma membrane
(R-HSA-5620912)
Antiviral mechanism by ifn-stimulated genes
(R-HSA-1169410)
Asparagine n-linked glycosylation
(R-HSA-446203)
Assembly and cell surface presentation of nmda receptors
(R-HSA-9609736)
Aurka activation by tpx2
(R-HSA-8854518)
Autophagy
(R-HSA-9612973)
Axon guidance
(R-HSA-422475)
Carboxyterminal post-translational modifications of tubulin
(R-HSA-8955332)
Cell cycle
(R-HSA-1640170)
Cell cycle, mitotic
(R-HSA-69278)
Cellular responses to stimuli
(R-HSA-8953897)
Cellular responses to stress
(R-HSA-2262752)
Centrosome maturation
(R-HSA-380287)
Chaperonin-mediated protein folding
(R-HSA-390466)
Cilium assembly
(R-HSA-5617833)
Cooperation of prefoldin and tric/cct in actin and tubulin folding
(R-HSA-389958)
Copi-dependent golgi-to-er retrograde traffic
(R-HSA-6811434)
Copi-independent golgi-to-er retrograde traffic
(R-HSA-6811436)
Copi-mediated anterograde transport
(R-HSA-6807878)
Cytokine signaling in immune system
(R-HSA-1280215)
Developmental biology
(R-HSA-1266738)
Disease
(R-HSA-1643685)
Eml4 and nudc in mitotic spindle formation
(R-HSA-9648025)
Er to golgi anterograde transport
(R-HSA-199977)
Factors involved in megakaryocyte development and platelet production
(R-HSA-983231)
Formation of tubulin folding intermediates by cct/tric
(R-HSA-389960)
G2/m transition
(R-HSA-69275)
Gap junction assembly
(R-HSA-190861)
Gap junction trafficking
(R-HSA-190828)
Gap junction trafficking and regulation
(R-HSA-157858)
Golgi-to-er retrograde transport
(R-HSA-8856688)
Hcmv early events
(R-HSA-9609690)
Hcmv infection
(R-HSA-9609646)
Hedgehog 'off' state
(R-HSA-5610787)
Hemostasis
(R-HSA-109582)
Hsp90 chaperone cycle for steroid hormone receptors (shr) in the presence of ligand
(R-HSA-3371497)
Immune system
(R-HSA-168256)
Infectious disease
(R-HSA-5663205)
Interferon signaling
(R-HSA-913531)
Intra-golgi and retrograde golgi-to-er traffic
(R-HSA-6811442)
Intraflagellar transport
(R-HSA-5620924)
Kinesins
(R-HSA-983189)
L1cam interactions
(R-HSA-373760)
Loss of nlp from mitotic centrosomes
(R-HSA-380259)
Loss of proteins required for interphase microtubule organization from the centrosome
(R-HSA-380284)
Macroautophagy
(R-HSA-1632852)
Membrane trafficking
(R-HSA-199991)
Metabolism of proteins
(R-HSA-392499)
Mhc class ii antigen presentation
(R-HSA-2132295)
Microtubule-dependent trafficking of connexons from golgi to the plasma membrane
(R-HSA-190840)
Mitotic anaphase
(R-HSA-68882)
Mitotic g2-g2/m phases
(R-HSA-453274)
Mitotic metaphase and anaphase
(R-HSA-2555396)
Mitotic prometaphase
(R-HSA-68877)
M phase
(R-HSA-68886)
Nervous system development
(R-HSA-9675108)
Neuronal system
(R-HSA-112316)
Neurotransmitter receptors and postsynaptic signal transmission
(R-HSA-112314)
Nuclear envelope (ne) reassembly
(R-HSA-2995410)
Organelle biogenesis and maintenance
(R-HSA-1852241)
Pkr-mediated signaling
(R-HSA-9833482)
Post-chaperonin tubulin folding pathway
(R-HSA-389977)
Post-translational protein modification
(R-HSA-597592)
Post nmda receptor activation events
(R-HSA-438064)
Prefoldin mediated transfer of substrate to cct/tric
(R-HSA-389957)
Protein folding
(R-HSA-391251)
Recruitment of mitotic centrosome proteins and complexes
(R-HSA-380270)
Recruitment of numa to mitotic centrosomes
(R-HSA-380320)
Recycling pathway of l1
(R-HSA-437239)
Regulation of plk1 activity at g2/m transition
(R-HSA-2565942)
Resolution of sister chromatid cohesion
(R-HSA-2500257)
Rho gtpase effectors
(R-HSA-195258)
Rho gtpases activate formins
(R-HSA-5663220)
Rho gtpases activate iqgaps
(R-HSA-5626467)
Sealing of the nuclear envelope (ne) by escrt-iii
(R-HSA-9668328)
Selective autophagy
(R-HSA-9663891)
Separation of sister chromatids
(R-HSA-2467813)
Signaling by hedgehog
(R-HSA-5358351)
Signaling by rho gtpases
(R-HSA-194315)
Signaling by rho gtpases, miro gtpases and rhobtb3
(R-HSA-9716542)
Signal transduction
(R-HSA-162582)
The role of gtse1 in g2/m progression after g2 checkpoint
(R-HSA-8852276)
Translocation of slc2a4 (glut4) to the plasma membrane
(R-HSA-1445148)
Transmission across chemical synapses
(R-HSA-112315)
Transport of connexons to the plasma membrane
(R-HSA-190872)
Transport to the golgi and subsequent modification
(R-HSA-948021)
Vesicle-mediated transport
(R-HSA-5653656)
Viral infection pathways
(R-HSA-9824446)
Gtp binding
(GO:0005525)
Hydrolase activity
(GO:0016787)
Identical protein binding
(GO:0042802)
Metal ion binding
(GO:0046872)
Protein-containing complex binding
(GO:0044877)
Protein binding
(GO:0005515)
Structural constituent of cytoskeleton
(GO:0005200)
Structural molecule activity
(GO:0005198)

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: chromaffin cell (CL0000166)
Fold Change: 9.42
Marker Score: 13259
Cell Name: neuron associated cell (sensu Vertebrata) (CL0000123)
Fold Change: 8.53
Marker Score: 44757
Cell Name: neuronal brush cell (CL0000555)
Fold Change: 5.91
Marker Score: 19818
Cell Name: Purkinje cell (CL0000121)
Fold Change: 5.65
Marker Score: 190764
Cell Name: granule cell (CL0000120)
Fold Change: 5.37
Marker Score: 40526
Cell Name: stellate neuron (CL0000122)
Fold Change: 4.5
Marker Score: 24183
Cell Name: macroglial cell (CL0000126)
Fold Change: 4.21
Marker Score: 9672
Cell Name: radial glial cell (CL0000681)
Fold Change: 3.76
Marker Score: 1386
Cell Name: glycinergic neuron (CL1001509)
Fold Change: 3.69
Marker Score: 4459
Cell Name: oligodendrocyte (CL0000128)
Fold Change: 3.65
Marker Score: 8739
Cell Name: retinal ganglion cell (CL0000740)
Fold Change: 3.6
Marker Score: 4495
Cell Name: alveolar capillary type 2 endothelial cell (CL4028003)
Fold Change: 3.5
Marker Score: 5073
Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
Fold Change: 3.49
Marker Score: 30352
Cell Name: mesodermal cell (CL0000222)
Fold Change: 3.44
Marker Score: 45372
Cell Name: glycinergic amacrine cell (CL4030028)
Fold Change: 3.38
Marker Score: 3188
Cell Name: Sertoli cell (CL0000216)
Fold Change: 3.36
Marker Score: 19902
Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
Fold Change: 3.23
Marker Score: 2031
Cell Name: uterine smooth muscle cell (CL0002601)
Fold Change: 3.11
Marker Score: 4055
Cell Name: ganglion interneuron (CL0000397)
Fold Change: 3.11
Marker Score: 943
Cell Name: mesenchymal stem cell (CL0000134)
Fold Change: 3.09
Marker Score: 4761
Cell Name: motor neuron (CL0000100)
Fold Change: 3.03
Marker Score: 1797
Cell Name: interstitial cell of ovary (CL0002094)
Fold Change: 3.01
Marker Score: 19555
Cell Name: fibroblast of connective tissue of nonglandular part of prostate (CL1000304)
Fold Change: 2.95
Marker Score: 2514
Cell Name: GABAergic amacrine cell (CL4030027)
Fold Change: 2.88
Marker Score: 5862
Cell Name: peripheral nervous system neuron (CL2000032)
Fold Change: 2.87
Marker Score: 3222
Cell Name: migratory enteric neural crest cell (CL0002607)
Fold Change: 2.87
Marker Score: 2700
Cell Name: smooth muscle cell of large intestine (CL1000279)
Fold Change: 2.84
Marker Score: 1076
Cell Name: central memory CD8-positive, alpha-beta T cell (CL0000907)
Fold Change: 2.84
Marker Score: 6932
Cell Name: decidual cell (CL2000002)
Fold Change: 2.84
Marker Score: 12236
Cell Name: supporting cell (CL0000630)
Fold Change: 2.83
Marker Score: 5320
Cell Name: T-helper 22 cell (CL0001042)
Fold Change: 2.83
Marker Score: 12140
Cell Name: inhibitory motor neuron (CL0008015)
Fold Change: 2.8
Marker Score: 1324
Cell Name: primary sensory neuron (sensu Teleostei) (CL0000531)
Fold Change: 2.8
Marker Score: 942
Cell Name: endocrine cell (CL0000163)
Fold Change: 2.76
Marker Score: 1430
Cell Name: blood cell (CL0000081)
Fold Change: 2.74
Marker Score: 31876
Cell Name: IgG-negative class switched memory B cell (CL0002117)
Fold Change: 2.71
Marker Score: 2669
Cell Name: neural crest cell (CL0011012)
Fold Change: 2.71
Marker Score: 2893.5
Cell Name: Mueller cell (CL0000636)
Fold Change: 2.69
Marker Score: 3728
Cell Name: smooth muscle cell (CL0000192)
Fold Change: 2.65
Marker Score: 1745
Cell Name: early pro-B cell (CL0002046)
Fold Change: 2.65
Marker Score: 26868
Cell Name: granulosa cell (CL0000501)
Fold Change: 2.65
Marker Score: 26644
Cell Name: mesenchymal cell (CL0008019)
Fold Change: 2.64
Marker Score: 4481.5
Cell Name: stromal cell of ovary (CL0002132)
Fold Change: 2.62
Marker Score: 29499
Cell Name: CD4-positive, alpha-beta cytotoxic T cell (CL0000934)
Fold Change: 2.62
Marker Score: 2298
Cell Name: bronchus fibroblast of lung (CL2000093)
Fold Change: 2.6
Marker Score: 3570
Cell Name: enteric smooth muscle cell (CL0002504)
Fold Change: 2.59
Marker Score: 6105.5
Cell Name: multi-ciliated epithelial cell (CL0005012)
Fold Change: 2.58
Marker Score: 4905
Cell Name: theca cell (CL0000503)
Fold Change: 2.55
Marker Score: 1826
Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
Fold Change: 2.54
Marker Score: 141795
Cell Name: CD34-positive, CD38-negative hematopoietic stem cell (CL0001024)
Fold Change: 2.52
Marker Score: 1828
Cell Name: epithelial cell of nephron (CL1000449)
Fold Change: 2.51
Marker Score: 5241.5
Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
Fold Change: 2.51
Marker Score: 7036
Cell Name: basophil (CL0000767)
Fold Change: 2.49
Marker Score: 1182
Cell Name: type EC enteroendocrine cell (CL0000577)
Fold Change: 2.48
Marker Score: 2338
Cell Name: ciliated cell (CL0000064)
Fold Change: 2.48
Marker Score: 8529
Cell Name: fibroblast of lung (CL0002553)
Fold Change: 2.47
Marker Score: 6465
Cell Name: lung ciliated cell (CL1000271)
Fold Change: 2.46
Marker Score: 1166
Cell Name: ovarian surface epithelial cell (CL2000064)
Fold Change: 2.46
Marker Score: 6683
Cell Name: effector memory CD8-positive, alpha-beta T cell, terminally differentiated (CL0001062)
Fold Change: 2.45
Marker Score: 3607
Cell Name: class switched memory B cell (CL0000972)
Fold Change: 2.45
Marker Score: 2300
Cell Name: effector memory CD4-positive, alpha-beta T cell (CL0000905)
Fold Change: 2.41
Marker Score: 1764
Cell Name: ciliated epithelial cell (CL0000067)
Fold Change: 2.4
Marker Score: 1095
Cell Name: alpha-beta T cell (CL0000789)
Fold Change: 2.39
Marker Score: 1812
Cell Name: type G enteroendocrine cell (CL0000508)
Fold Change: 2.38
Marker Score: 821
Cell Name: alveolar capillary type 1 endothelial cell (CL4028002)
Fold Change: 2.38
Marker Score: 6053
Cell Name: myofibroblast cell (CL0000186)
Fold Change: 2.37
Marker Score: 2927
Cell Name: enteroendocrine cell (CL0000164)
Fold Change: 2.37
Marker Score: 1226
Cell Name: mammary gland epithelial cell (CL0002327)
Fold Change: 2.35
Marker Score: 835
Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
Fold Change: 2.35
Marker Score: 1975
Cell Name: Unknown (CL0002371)
Fold Change: 2.32
Marker Score: 2460
Cell Name: pro-T cell (CL0000827)
Fold Change: 2.28
Marker Score: 9349
Cell Name: retinal rod cell (CL0000604)
Fold Change: 2.28
Marker Score: 6497
Cell Name: pericyte (CL0000669)
Fold Change: 2.27
Marker Score: 1324
Cell Name: DN3 thymocyte (CL0000807)
Fold Change: 2.26
Marker Score: 1128
Cell Name: capillary endothelial cell (CL0002144)
Fold Change: 2.26
Marker Score: 2429
Cell Name: Unknown (CL0000548)
Fold Change: 2.26
Marker Score: 1645
Cell Name: oligodendrocyte precursor cell (CL0002453)
Fold Change: 2.25
Marker Score: 2778
Cell Name: mature T cell (CL0002419)
Fold Change: 2.23
Marker Score: 22093
Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: 2.23
Marker Score: 8598
Cell Name: hematopoietic precursor cell (CL0008001)
Fold Change: 2.21
Marker Score: 773
Cell Name: glial cell (CL0000125)
Fold Change: 2.19
Marker Score: 2409
Cell Name: large pre-B-II cell (CL0000957)
Fold Change: 2.18
Marker Score: 5923
Cell Name: cell of skeletal muscle (CL0000188)
Fold Change: 2.17
Marker Score: 1652
Cell Name: interstitial cell of Cajal (CL0002088)
Fold Change: 2.16
Marker Score: 748
Cell Name: CD16-negative, CD56-bright natural killer cell, human (CL0000938)
Fold Change: 2.15
Marker Score: 1765
Cell Name: muscle cell (CL0000187)
Fold Change: 2.15
Marker Score: 610
Cell Name: effector CD4-positive, alpha-beta T cell (CL0001044)
Fold Change: 2.15
Marker Score: 2009
Cell Name: lung macrophage (CL1001603)
Fold Change: 2.14
Marker Score: 2449
Cell Name: glandular epithelial cell (CL0000150)
Fold Change: 2.14
Marker Score: 5254
Cell Name: skeletal muscle satellite stem cell (CL0008011)
Fold Change: 2.12
Marker Score: 2265
Cell Name: type A enteroendocrine cell (CL0002067)
Fold Change: 2.12
Marker Score: 854
Cell Name: CD4-positive helper T cell (CL0000492)
Fold Change: 2.11
Marker Score: 2298
Cell Name: CD14-positive, CD16-positive monocyte (CL0002397)
Fold Change: 2.11
Marker Score: 4115
Cell Name: endocardial cell (CL0002350)
Fold Change: 2.11
Marker Score: 1192
Cell Name: fibroblast of mammary gland (CL0002555)
Fold Change: 2.1
Marker Score: 71322
Cell Name: granulocyte (CL0000094)
Fold Change: 2.09
Marker Score: 939
Cell Name: non-classical monocyte (CL0000875)
Fold Change: 2.09
Marker Score: 5036
Cell Name: fetal cardiomyocyte (CL0002495)
Fold Change: 2.07
Marker Score: 682
Cell Name: effector memory CD8-positive, alpha-beta T cell (CL0000913)
Fold Change: 2.06
Marker Score: 1270
Cell Name: PP cell (CL0000696)
Fold Change: 2.06
Marker Score: 465

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**Key Characteristics** TUBA1A is a gene that encodes for a protein subunit of microtubules. Microtubules are dynamic structures composed of tubulin dimers, and TUBA1A is one of the several subunits that make up microtubules. The TUBA1A protein is characterized by its ability to interact with other microtubule subunits and other proteins to form microtubules. The TUBA1A protein also undergoes post-translational modifications, such as carboxyterminal post-translational modifications, which are essential for its function. **Pathways and Functions** TUBA1A is involved in various cellular processes, including: 1. **Cell division**: Microtubules are essential for the proper segregation of chromosomes during cell division. TUBA1A is involved in the formation of microtubules that interact with the mitotic spindle. 2. **Axon guidance**: Microtubules play a crucial role in axon guidance, and TUBA1A is involved in the formation of microtubules that interact with growth cones and other axonal structures. 3. **Neurotransmitter release**: Microtubules are involved in the regulation of neurotransmitter release, and TUBA1A is involved in the formation of microtubules that interact with synaptic vesicles. 4. **Antiviral mechanisms**: TUBA1A is involved in the regulation of antiviral mechanisms, including the activation of interferon-stimulated genes. TUBA1A also interacts with other proteins and pathways, including: 1. **AMPK**: TUBA1A is involved in the activation of AMPK downstream of NMDA receptors. 2. **NMDA receptors**: TUBA1A is involved in the assembly and cell surface presentation of NMDA receptors. 3. **Autophagy**: TUBA1A is involved in the regulation of autophagy, a process by which cells recycle damaged or dysfunctional components. 4. **Hedgehog signaling**: TUBA1A is involved in the regulation of hedgehog signaling, a pathway that is involved in developmental biology and disease. **Clinical Significance** Dysregulation of TUBA1A has been implicated in various neurological disorders, including: 1. **Neurodegenerative diseases**: TUBA1A dysregulation has been implicated in neurodegenerative diseases such as Alzheimer's disease, Parkinson's disease, and Huntington's disease. 2. **Cancer**: TUBA1A dysregulation has been implicated in cancer, including glioblastoma and breast cancer. 3. **Neurodevelopmental disorders**: TUBA1A dysregulation has been implicated in neurodevelopmental disorders such as autism and schizophrenia. In summary, TUBA1A is a critical gene that encodes for a protein subunit of microtubules, which are essential components of the cytoskeleton. The protein product of this gene is involved in various cellular processes, including cell division, axon guidance, and neurotransmitter release. Dysregulation of TUBA1A has been implicated in various neurological disorders, highlighting the importance of this gene in human health and disease.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

Tubulin alpha-1A chain

Genular Protein ID: 4130409146

Symbol: TBA1A_HUMAN

Name: Tubulin alpha-1A chain

UniProtKB Accession Codes:

Q71U36 A8K0B8 G3V1U9 P04687 P05209

Database IDs:

Citations:

PubMed ID: 3839072

Title: Structural features and restricted expression of a human alpha-tubulin gene.

PubMed ID: 3839072

DOI: 10.1093/nar/13.1.207

PubMed ID: 11504633

Title: Tubulins in the primate retina: evidence that xanthophylls may be endogenous ligands for the paclitaxel-binding site.

PubMed ID: 11504633

DOI: 10.1016/s0968-0896(01)00103-1

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16541075

Title: The finished DNA sequence of human chromosome 12.

PubMed ID: 16541075

DOI: 10.1038/nature04569

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 6646120

Title: Expression of human alpha-tubulin genes: interspecies conservation of 3' untranslated regions.

PubMed ID: 6646120

DOI: 10.1128/mcb.3.10.1738-1745.1983

PubMed ID: 10339593

Title: Microtubule dysfunction by posttranslational nitrotyrosination of alpha-tubulin: a nitric oxide-dependent mechanism of cellular injury.

PubMed ID: 10339593

DOI: 10.1073/pnas.96.11.6365

PubMed ID: 17584854

Title: Large spectrum of lissencephaly and pachygyria phenotypes resulting from de novo missense mutations in tubulin alpha 1A (TUBA1A).

PubMed ID: 17584854

DOI: 10.1002/humu.20572

PubMed ID: 19524510

Title: Evolutionary divergence of enzymatic mechanisms for posttranslational polyglycylation.

PubMed ID: 19524510

DOI: 10.1016/j.cell.2009.05.020

PubMed ID: 24906155

Title: Molecular basis for age-dependent microtubule acetylation by tubulin acetyltransferase.

PubMed ID: 24906155

DOI: 10.1016/j.cell.2014.03.061

PubMed ID: 25908662

Title: Mitosis. Microtubule detyrosination guides chromosomes during mitosis.

PubMed ID: 25908662

DOI: 10.1126/science.aaa5175

PubMed ID: 26875866

Title: Graded control of microtubule severing by tubulin glutamylation.

PubMed ID: 26875866

DOI: 10.1016/j.cell.2016.01.019

PubMed ID: 27518565

Title: Dual chromatin and cytoskeletal remodeling by SETD2.

PubMed ID: 27518565

DOI: 10.1016/j.cell.2016.07.005

PubMed ID: 26972003

Title: Alpha-tubulin tyrosination and CLIP-170 phosphorylation regulate the initiation of dynein-driven transport in neurons.

PubMed ID: 26972003

DOI: 10.1016/j.celrep.2016.02.046

PubMed ID: 26968983

Title: Tyrosination of alpha-tubulin controls the initiation of processive dynein-dynactin motility.

PubMed ID: 26968983

DOI: 10.15252/embj.201593071

PubMed ID: 29146869

Title: Vasohibins encode tubulin detyrosinating activity.

PubMed ID: 29146869

DOI: 10.1126/science.aao5676

PubMed ID: 32747782

Title: Structural basis for polyglutamate chain initiation and elongation by TTLL family enzymes.

PubMed ID: 32747782

DOI: 10.1038/s41594-020-0462-0

PubMed ID: 35482892

Title: Posttranslational modification of microtubules by the MATCAP detyrosinase.

PubMed ID: 35482892

DOI: 10.1126/science.abn6020

PubMed ID: 36191189

Title: SPACA9 is a lumenal protein of human ciliary singlet and doublet microtubules.

PubMed ID: 36191189

DOI: 10.1073/pnas.2207605119

PubMed ID: 25818041

Title: Diagnostic yield of genetic testing in epileptic encephalopathy in childhood.

PubMed ID: 25818041

DOI: 10.1111/epi.12954

Sequence Information:

Length: 451
Mass: 50136
Checksum: 00F8429A4A10E5FE
Sequence:

MRECISIHVG QAGVQIGNAC WELYCLEHGI QPDGQMPSDK TIGGGDDSFN TFFSETGAGK 
HVPRAVFVDL EPTVIDEVRT GTYRQLFHPE QLITGKEDAA NNYARGHYTI GKEIIDLVLD 
RIRKLADQCT GLQGFLVFHS FGGGTGSGFT SLLMERLSVD YGKKSKLEFS IYPAPQVSTA 
VVEPYNSILT THTTLEHSDC AFMVDNEAIY DICRRNLDIE RPTYTNLNRL IGQIVSSITA 
SLRFDGALNV DLTEFQTNLV PYPRIHFPLA TYAPVISAEK AYHEQLSVAE ITNACFEPAN 
QMVKCDPRHG KYMACCLLYR GDVVPKDVNA AIATIKTKRT IQFVDWCPTG FKVGINYQPP 
TVVPGGDLAK VQRAVCMLSN TTAIAEAWAR LDHKFDLMYA KRAFVHWYVG EGMEEGEFSE 
AREDMAALEK DYEEVGVDSV EGEGEEEGEE Y

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.

Details for: TUBA1A

Associated with

Cells (max top 100)

Other Information

Structural features and restricted expression of a human alpha-tubulin gene. PubMed ID: 3839072

Tubulins in the primate retina: evidence that xanthophylls may be endogenous ligands for the paclitaxel-binding site. PubMed ID: 11504633

Complete sequencing and characterization of 21,243 full-length human cDNAs. PubMed ID: 14702039

The finished DNA sequence of human chromosome 12. PubMed ID: 16541075

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Expression of human alpha-tubulin genes: interspecies conservation of 3' untranslated regions. PubMed ID: 6646120

Microtubule dysfunction by posttranslational nitrotyrosination of alpha-tubulin: a nitric oxide-dependent mechanism of cellular injury. PubMed ID: 10339593

Large spectrum of lissencephaly and pachygyria phenotypes resulting from de novo missense mutations in tubulin alpha 1A (TUBA1A). PubMed ID: 17584854

Evolutionary divergence of enzymatic mechanisms for posttranslational polyglycylation. PubMed ID: 19524510

Molecular basis for age-dependent microtubule acetylation by tubulin acetyltransferase. PubMed ID: 24906155

Mitosis. Microtubule detyrosination guides chromosomes during mitosis. PubMed ID: 25908662

Graded control of microtubule severing by tubulin glutamylation. PubMed ID: 26875866

Dual chromatin and cytoskeletal remodeling by SETD2. PubMed ID: 27518565

Alpha-tubulin tyrosination and CLIP-170 phosphorylation regulate the initiation of dynein-driven transport in neurons. PubMed ID: 26972003

Tyrosination of alpha-tubulin controls the initiation of processive dynein-dynactin motility. PubMed ID: 26968983

Vasohibins encode tubulin detyrosinating activity. PubMed ID: 29146869

Structural basis for polyglutamate chain initiation and elongation by TTLL family enzymes. PubMed ID: 32747782

Posttranslational modification of microtubules by the MATCAP detyrosinase. PubMed ID: 35482892

SPACA9 is a lumenal protein of human ciliary singlet and doublet microtubules. PubMed ID: 36191189

Diagnostic yield of genetic testing in epileptic encephalopathy in childhood. PubMed ID: 25818041