TUBA1A | ENSG00000167552 | NCBI 7846

Details for: TUBA1A

Gene ID: 7846

Symbol: TUBA1A

Ensembl ID: ENSG00000167552

Description: tubulin alpha 1a

Associated with

Activation of ampk downstream of nmdars
(R-HSA-9619483)
Activation of nmda receptors and postsynaptic events
(R-HSA-442755)
Adaptive immune system
(R-HSA-1280218)
Aggrephagy
(R-HSA-9646399)
Anchoring of the basal body to the plasma membrane
(R-HSA-5620912)
Antiviral mechanism by ifn-stimulated genes
(R-HSA-1169410)
Asparagine n-linked glycosylation
(R-HSA-446203)
Assembly and cell surface presentation of nmda receptors
(R-HSA-9609736)
Aurka activation by tpx2
(R-HSA-8854518)
Autophagy
(R-HSA-9612973)
Axon guidance
(R-HSA-422475)
Carboxyterminal post-translational modifications of tubulin
(R-HSA-8955332)
Cell cycle
(R-HSA-1640170)
Cell cycle, mitotic
(R-HSA-69278)
Cellular responses to stimuli
(R-HSA-8953897)
Cellular responses to stress
(R-HSA-2262752)
Centrosome maturation
(R-HSA-380287)
Chaperonin-mediated protein folding
(R-HSA-390466)
Cilium assembly
(R-HSA-5617833)
Cooperation of prefoldin and tric/cct in actin and tubulin folding
(R-HSA-389958)
Copi-dependent golgi-to-er retrograde traffic
(R-HSA-6811434)
Copi-independent golgi-to-er retrograde traffic
(R-HSA-6811436)
Copi-mediated anterograde transport
(R-HSA-6807878)
Cytokine signaling in immune system
(R-HSA-1280215)
Developmental biology
(R-HSA-1266738)
Disease
(R-HSA-1643685)
Eml4 and nudc in mitotic spindle formation
(R-HSA-9648025)
Er to golgi anterograde transport
(R-HSA-199977)
Factors involved in megakaryocyte development and platelet production
(R-HSA-983231)
Formation of tubulin folding intermediates by cct/tric
(R-HSA-389960)
G2/m transition
(R-HSA-69275)
Gap junction assembly
(R-HSA-190861)
Gap junction trafficking
(R-HSA-190828)
Gap junction trafficking and regulation
(R-HSA-157858)
Golgi-to-er retrograde transport
(R-HSA-8856688)
Hcmv early events
(R-HSA-9609690)
Hcmv infection
(R-HSA-9609646)
Hedgehog 'off' state
(R-HSA-5610787)
Hemostasis
(R-HSA-109582)
Hsp90 chaperone cycle for steroid hormone receptors (shr) in the presence of ligand
(R-HSA-3371497)
Immune system
(R-HSA-168256)
Infectious disease
(R-HSA-5663205)
Interferon signaling
(R-HSA-913531)
Intra-golgi and retrograde golgi-to-er traffic
(R-HSA-6811442)
Intraflagellar transport
(R-HSA-5620924)
Kinesins
(R-HSA-983189)
L1cam interactions
(R-HSA-373760)
Loss of nlp from mitotic centrosomes
(R-HSA-380259)
Loss of proteins required for interphase microtubule organization from the centrosome
(R-HSA-380284)
Macroautophagy
(R-HSA-1632852)
Membrane trafficking
(R-HSA-199991)
Metabolism of proteins
(R-HSA-392499)
Mhc class ii antigen presentation
(R-HSA-2132295)
Microtubule-dependent trafficking of connexons from golgi to the plasma membrane
(R-HSA-190840)
Mitotic anaphase
(R-HSA-68882)
Mitotic g2-g2/m phases
(R-HSA-453274)
Mitotic metaphase and anaphase
(R-HSA-2555396)
Mitotic prometaphase
(R-HSA-68877)
M phase
(R-HSA-68886)
Nervous system development
(R-HSA-9675108)
Neuronal system
(R-HSA-112316)
Neurotransmitter receptors and postsynaptic signal transmission
(R-HSA-112314)
Nuclear envelope (ne) reassembly
(R-HSA-2995410)
Organelle biogenesis and maintenance
(R-HSA-1852241)
Pkr-mediated signaling
(R-HSA-9833482)
Post-chaperonin tubulin folding pathway
(R-HSA-389977)
Post-translational protein modification
(R-HSA-597592)
Post nmda receptor activation events
(R-HSA-438064)
Prefoldin mediated transfer of substrate to cct/tric
(R-HSA-389957)
Protein folding
(R-HSA-391251)
Recruitment of mitotic centrosome proteins and complexes
(R-HSA-380270)
Recruitment of numa to mitotic centrosomes
(R-HSA-380320)
Recycling pathway of l1
(R-HSA-437239)
Regulation of plk1 activity at g2/m transition
(R-HSA-2565942)
Resolution of sister chromatid cohesion
(R-HSA-2500257)
Rho gtpase effectors
(R-HSA-195258)
Rho gtpases activate formins
(R-HSA-5663220)
Rho gtpases activate iqgaps
(R-HSA-5626467)
Sealing of the nuclear envelope (ne) by escrt-iii
(R-HSA-9668328)
Selective autophagy
(R-HSA-9663891)
Separation of sister chromatids
(R-HSA-2467813)
Signaling by hedgehog
(R-HSA-5358351)
Signaling by rho gtpases
(R-HSA-194315)
Signaling by rho gtpases, miro gtpases and rhobtb3
(R-HSA-9716542)
Signal transduction
(R-HSA-162582)
The role of gtse1 in g2/m progression after g2 checkpoint
(R-HSA-8852276)
Translocation of slc2a4 (glut4) to the plasma membrane
(R-HSA-1445148)
Transmission across chemical synapses
(R-HSA-112315)
Transport of connexons to the plasma membrane
(R-HSA-190872)
Transport to the golgi and subsequent modification
(R-HSA-948021)
Vesicle-mediated transport
(R-HSA-5653656)
Viral infection pathways
(R-HSA-9824446)
Gtp binding
(GO:0005525)
Hydrolase activity
(GO:0016787)
Identical protein binding
(GO:0042802)
Metal ion binding
(GO:0046872)
Protein-containing complex binding
(GO:0044877)
Protein binding
(GO:0005515)
Structural constituent of cytoskeleton
(GO:0005200)
Structural molecule activity
(GO:0005198)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: polychromatophilic erythroblast (CL0000550)
Fold Change: 678.8379
Cell Significance Index: -105.5900
Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
Fold Change: 323.9588
Cell Significance Index: -82.1700
Cell Name: embryonic stem cell (CL0002322)
Fold Change: 249.4249
Cell Significance Index: -102.7500
Cell Name: mucosal type mast cell (CL0000485)
Fold Change: 225.0299
Cell Significance Index: -91.4200
Cell Name: smooth muscle fiber of ileum (CL1000278)
Fold Change: 216.9775
Cell Significance Index: -102.4400
Cell Name: peripheral blood mononuclear cell (CL2000001)
Fold Change: 199.8891
Cell Significance Index: -102.8200
Cell Name: ileal goblet cell (CL1000326)
Fold Change: 155.0172
Cell Significance Index: -104.0200
Cell Name: ciliated cell of the bronchus (CL0002332)
Fold Change: 95.9944
Cell Significance Index: -91.6500
Cell Name: orthochromatic erythroblast (CL0000552)
Fold Change: 88.3162
Cell Significance Index: -108.8900
Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
Fold Change: 29.3998
Cell Significance Index: -90.3000
Cell Name: stromal cell of bone marrow (CL0010001)
Fold Change: 28.3879
Cell Significance Index: -112.0200
Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
Fold Change: 25.2234
Cell Significance Index: -67.5700
Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
Fold Change: 9.7981
Cell Significance Index: 340.4800
Cell Name: fibroblast of dermis (CL0002551)
Fold Change: 7.7596
Cell Significance Index: 162.4200
Cell Name: glycinergic neuron (CL1001509)
Fold Change: 7.4911
Cell Significance Index: 393.3100
Cell Name: forebrain neuroblast (CL1000042)
Fold Change: 7.2986
Cell Significance Index: 448.6100
Cell Name: granulosa cell (CL0000501)
Fold Change: 7.2360
Cell Significance Index: 190.2700
Cell Name: retinal progenitor cell (CL0002672)
Fold Change: 5.0145
Cell Significance Index: 281.3900
Cell Name: odontoblast (CL0000060)
Fold Change: 4.5178
Cell Significance Index: 579.1600
Cell Name: midget ganglion cell of retina (CL4023188)
Fold Change: 4.1140
Cell Significance Index: 42.8600
Cell Name: interstitial cell of ovary (CL0002094)
Fold Change: 4.1127
Cell Significance Index: 52.6700
Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
Fold Change: 3.6322
Cell Significance Index: 170.7100
Cell Name: early pro-B cell (CL0002046)
Fold Change: 3.4362
Cell Significance Index: 221.6900
Cell Name: cortical interneuron (CL0008031)
Fold Change: 3.4129
Cell Significance Index: 81.8500
Cell Name: skeletal muscle myoblast (CL0000515)
Fold Change: 3.3161
Cell Significance Index: 36.0500
Cell Name: sensory neuron (CL0000101)
Fold Change: 2.9661
Cell Significance Index: 16.8600
Cell Name: stromal cell of ovary (CL0002132)
Fold Change: 2.9497
Cell Significance Index: 405.0700
Cell Name: lactocyte (CL0002325)
Fold Change: 2.6774
Cell Significance Index: 345.9000
Cell Name: Sertoli cell (CL0000216)
Fold Change: 2.2351
Cell Significance Index: 31.3500
Cell Name: cerebellar granule cell (CL0001031)
Fold Change: 2.2238
Cell Significance Index: 38.1100
Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: 2.0461
Cell Significance Index: 152.5000
Cell Name: retinal rod cell (CL0000604)
Fold Change: 1.9450
Cell Significance Index: 23.1900
Cell Name: hair follicular keratinocyte (CL2000092)
Fold Change: 1.8527
Cell Significance Index: 819.1300
Cell Name: enteric smooth muscle cell (CL0002504)
Fold Change: 1.8225
Cell Significance Index: 9.5900
Cell Name: cell in vitro (CL0001034)
Fold Change: 1.7645
Cell Significance Index: 963.6100
Cell Name: Purkinje cell (CL0000121)
Fold Change: 1.4144
Cell Significance Index: 30.9700
Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
Fold Change: 1.2855
Cell Significance Index: 23.7600
Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: 1.2603
Cell Significance Index: 252.8200
Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 1.0817
Cell Significance Index: 175.9300
Cell Name: theca cell (CL0000503)
Fold Change: 0.9630
Cell Significance Index: 5.6600
Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: 0.8239
Cell Significance Index: 295.5300
Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 0.5890
Cell Significance Index: 64.0600
Cell Name: fibroblast of mammary gland (CL0002555)
Fold Change: 0.5557
Cell Significance Index: 15.9300
Cell Name: GABAergic amacrine cell (CL4030027)
Fold Change: 0.5011
Cell Significance Index: 6.2200
Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: 0.4400
Cell Significance Index: 83.7400
Cell Name: vascular lymphangioblast (CL0005022)
Fold Change: 0.3828
Cell Significance Index: 6.7700
Cell Name: peg cell (CL4033014)
Fold Change: 0.2939
Cell Significance Index: 6.7900
Cell Name: secondary lens fiber (CL0002225)
Fold Change: 0.1281
Cell Significance Index: 174.1300
Cell Name: cone retinal bipolar cell (CL0000752)
Fold Change: 0.1194
Cell Significance Index: 0.9200
Cell Name: mesenchymal cell (CL0008019)
Fold Change: 0.1171
Cell Significance Index: 1.9600
Cell Name: colon goblet cell (CL0009039)
Fold Change: 0.0650
Cell Significance Index: 6.4300
Cell Name: microfold cell of epithelium of small intestine (CL1000353)
Fold Change: 0.0002
Cell Significance Index: 0.0100
Cell Name: pancreatic PP cell (CL0002275)
Fold Change: -0.0072
Cell Significance Index: -4.4900
Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: -0.0193
Cell Significance Index: -36.3200
Cell Name: pancreatic A cell (CL0000171)
Fold Change: -0.0315
Cell Significance Index: -23.3300
Cell Name: lens epithelial cell (CL0002224)
Fold Change: -0.0394
Cell Significance Index: -60.6000
Cell Name: anterior lens cell (CL0002223)
Fold Change: -0.0437
Cell Significance Index: -80.6700
Cell Name: small intestine goblet cell (CL1000495)
Fold Change: -0.0452
Cell Significance Index: -1.5900
Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: -0.0666
Cell Significance Index: -1.9200
Cell Name: pulmonary alveolar epithelial cell (CL0000322)
Fold Change: -0.0734
Cell Significance Index: -55.5600
Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
Fold Change: -0.1081
Cell Significance Index: -79.2300
Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: -0.1212
Cell Significance Index: -76.9500
Cell Name: type B pancreatic cell (CL0000169)
Fold Change: -0.1225
Cell Significance Index: -69.0700
Cell Name: pancreatic D cell (CL0000173)
Fold Change: -0.1547
Cell Significance Index: -32.5900
Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: -0.1767
Cell Significance Index: -30.1700
Cell Name: glioblast (CL0000030)
Fold Change: -0.1975
Cell Significance Index: -1.2400
Cell Name: ciliary muscle cell (CL1000443)
Fold Change: -0.1980
Cell Significance Index: -89.8800
Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: -0.2135
Cell Significance Index: -9.6800
Cell Name: hippocampal granule cell (CL0001033)
Fold Change: -0.2475
Cell Significance Index: -16.6400
Cell Name: eye photoreceptor cell (CL0000287)
Fold Change: -0.2612
Cell Significance Index: -16.4600
Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: -0.2680
Cell Significance Index: -30.7100
Cell Name: abnormal cell (CL0001061)
Fold Change: -0.2707
Cell Significance Index: -27.6500
Cell Name: neutrophil progenitor cell (CL0000834)
Fold Change: -0.2753
Cell Significance Index: -7.3700
Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: -0.3103
Cell Significance Index: -45.1100
Cell Name: intermediate cell of urothelium (CL4030055)
Fold Change: -0.3330
Cell Significance Index: -60.0300
Cell Name: dopaminergic neuron (CL0000700)
Fold Change: -0.3381
Cell Significance Index: -97.2800
Cell Name: neoplastic cell (CL0001063)
Fold Change: -0.3926
Cell Significance Index: -77.9100
Cell Name: pancreatic endocrine cell (CL0008024)
Fold Change: -0.3936
Cell Significance Index: -44.9300
Cell Name: tonsil germinal center B cell (CL2000006)
Fold Change: -0.4016
Cell Significance Index: -47.3600
Cell Name: basal cell of urothelium (CL1000486)
Fold Change: -0.4638
Cell Significance Index: -57.0300
Cell Name: gut absorptive cell (CL0000677)
Fold Change: -0.5220
Cell Significance Index: -31.3400
Cell Name: endothelial cell of venule (CL1000414)
Fold Change: -0.5537
Cell Significance Index: -6.2900
Cell Name: epithelial cell of stomach (CL0002178)
Fold Change: -0.6811
Cell Significance Index: -79.3700
Cell Name: sebum secreting cell (CL0000317)
Fold Change: -0.6947
Cell Significance Index: -49.1300
Cell Name: pro-T cell (CL0000827)
Fold Change: -0.7886
Cell Significance Index: -20.1500
Cell Name: paneth cell of epithelium of small intestine (CL1000343)
Fold Change: -0.7888
Cell Significance Index: -17.0900
Cell Name: basal cell of prostate epithelium (CL0002341)
Fold Change: -0.8064
Cell Significance Index: -21.9500
Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: -0.9742
Cell Significance Index: -45.4200
Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
Fold Change: -1.0392
Cell Significance Index: -30.5200
Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: -1.0760
Cell Significance Index: -112.0400
Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
Fold Change: -1.2249
Cell Significance Index: -97.0100
Cell Name: hippocampal pyramidal neuron (CL1001571)
Fold Change: -1.2528
Cell Significance Index: -35.7500
Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
Fold Change: -1.3605
Cell Significance Index: -38.0200
Cell Name: neuroblast (sensu Nematoda and Protostomia) (CL0000338)
Fold Change: -1.4147
Cell Significance Index: -12.8600
Cell Name: microcirculation associated smooth muscle cell (CL0008035)
Fold Change: -1.4596
Cell Significance Index: -12.2600
Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: -1.4607
Cell Significance Index: -112.0900
Cell Name: lung endothelial cell (CL1001567)
Fold Change: -1.5758
Cell Significance Index: -82.0800
Cell Name: intestinal tuft cell (CL0019032)
Fold Change: -1.6665
Cell Significance Index: -102.1700
Cell Name: L6b glutamatergic cortical neuron (CL4023038)
Fold Change: -1.6680
Cell Significance Index: -54.6100
Cell Name: indirect pathway medium spiny neuron (CL4023029)
Fold Change: -1.6949
Cell Significance Index: -74.9700

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

**Key Characteristics** TUBA1A is a gene that encodes for a protein subunit of microtubules. Microtubules are dynamic structures composed of tubulin dimers, and TUBA1A is one of the several subunits that make up microtubules. The TUBA1A protein is characterized by its ability to interact with other microtubule subunits and other proteins to form microtubules. The TUBA1A protein also undergoes post-translational modifications, such as carboxyterminal post-translational modifications, which are essential for its function. **Pathways and Functions** TUBA1A is involved in various cellular processes, including: 1. **Cell division**: Microtubules are essential for the proper segregation of chromosomes during cell division. TUBA1A is involved in the formation of microtubules that interact with the mitotic spindle. 2. **Axon guidance**: Microtubules play a crucial role in axon guidance, and TUBA1A is involved in the formation of microtubules that interact with growth cones and other axonal structures. 3. **Neurotransmitter release**: Microtubules are involved in the regulation of neurotransmitter release, and TUBA1A is involved in the formation of microtubules that interact with synaptic vesicles. 4. **Antiviral mechanisms**: TUBA1A is involved in the regulation of antiviral mechanisms, including the activation of interferon-stimulated genes. TUBA1A also interacts with other proteins and pathways, including: 1. **AMPK**: TUBA1A is involved in the activation of AMPK downstream of NMDA receptors. 2. **NMDA receptors**: TUBA1A is involved in the assembly and cell surface presentation of NMDA receptors. 3. **Autophagy**: TUBA1A is involved in the regulation of autophagy, a process by which cells recycle damaged or dysfunctional components. 4. **Hedgehog signaling**: TUBA1A is involved in the regulation of hedgehog signaling, a pathway that is involved in developmental biology and disease. **Clinical Significance** Dysregulation of TUBA1A has been implicated in various neurological disorders, including: 1. **Neurodegenerative diseases**: TUBA1A dysregulation has been implicated in neurodegenerative diseases such as Alzheimer's disease, Parkinson's disease, and Huntington's disease. 2. **Cancer**: TUBA1A dysregulation has been implicated in cancer, including glioblastoma and breast cancer. 3. **Neurodevelopmental disorders**: TUBA1A dysregulation has been implicated in neurodevelopmental disorders such as autism and schizophrenia. In summary, TUBA1A is a critical gene that encodes for a protein subunit of microtubules, which are essential components of the cytoskeleton. The protein product of this gene is involved in various cellular processes, including cell division, axon guidance, and neurotransmitter release. Dysregulation of TUBA1A has been implicated in various neurological disorders, highlighting the importance of this gene in human health and disease.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

Tubulin alpha-1A chain

Genular Protein ID: 4130409146

Symbol: TBA1A_HUMAN

Name: Tubulin alpha-1A chain

UniProtKB Accession Codes:

Q71U36 A8K0B8 G3V1U9 P04687 P05209

Database IDs:

Citations:

PubMed ID: 3839072

Title: Structural features and restricted expression of a human alpha-tubulin gene.

PubMed ID: 3839072

DOI: 10.1093/nar/13.1.207

PubMed ID: 11504633

Title: Tubulins in the primate retina: evidence that xanthophylls may be endogenous ligands for the paclitaxel-binding site.

PubMed ID: 11504633

DOI: 10.1016/s0968-0896(01)00103-1

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16541075

Title: The finished DNA sequence of human chromosome 12.

PubMed ID: 16541075

DOI: 10.1038/nature04569

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 6646120

Title: Expression of human alpha-tubulin genes: interspecies conservation of 3' untranslated regions.

PubMed ID: 6646120

DOI: 10.1128/mcb.3.10.1738-1745.1983

PubMed ID: 10339593

Title: Microtubule dysfunction by posttranslational nitrotyrosination of alpha-tubulin: a nitric oxide-dependent mechanism of cellular injury.

PubMed ID: 10339593

DOI: 10.1073/pnas.96.11.6365

PubMed ID: 17584854

Title: Large spectrum of lissencephaly and pachygyria phenotypes resulting from de novo missense mutations in tubulin alpha 1A (TUBA1A).

PubMed ID: 17584854

DOI: 10.1002/humu.20572

PubMed ID: 19524510

Title: Evolutionary divergence of enzymatic mechanisms for posttranslational polyglycylation.

PubMed ID: 19524510

DOI: 10.1016/j.cell.2009.05.020

PubMed ID: 24906155

Title: Molecular basis for age-dependent microtubule acetylation by tubulin acetyltransferase.

PubMed ID: 24906155

DOI: 10.1016/j.cell.2014.03.061

PubMed ID: 25908662

Title: Mitosis. Microtubule detyrosination guides chromosomes during mitosis.

PubMed ID: 25908662

DOI: 10.1126/science.aaa5175

PubMed ID: 26875866

Title: Graded control of microtubule severing by tubulin glutamylation.

PubMed ID: 26875866

DOI: 10.1016/j.cell.2016.01.019

PubMed ID: 27518565

Title: Dual chromatin and cytoskeletal remodeling by SETD2.

PubMed ID: 27518565

DOI: 10.1016/j.cell.2016.07.005

PubMed ID: 26972003

Title: Alpha-tubulin tyrosination and CLIP-170 phosphorylation regulate the initiation of dynein-driven transport in neurons.

PubMed ID: 26972003

DOI: 10.1016/j.celrep.2016.02.046

PubMed ID: 26968983

Title: Tyrosination of alpha-tubulin controls the initiation of processive dynein-dynactin motility.

PubMed ID: 26968983

DOI: 10.15252/embj.201593071

PubMed ID: 29146869

Title: Vasohibins encode tubulin detyrosinating activity.

PubMed ID: 29146869

DOI: 10.1126/science.aao5676

PubMed ID: 32747782

Title: Structural basis for polyglutamate chain initiation and elongation by TTLL family enzymes.

PubMed ID: 32747782

DOI: 10.1038/s41594-020-0462-0

PubMed ID: 35482892

Title: Posttranslational modification of microtubules by the MATCAP detyrosinase.

PubMed ID: 35482892

DOI: 10.1126/science.abn6020

PubMed ID: 36191189

Title: SPACA9 is a lumenal protein of human ciliary singlet and doublet microtubules.

PubMed ID: 36191189

DOI: 10.1073/pnas.2207605119

PubMed ID: 25818041

Title: Diagnostic yield of genetic testing in epileptic encephalopathy in childhood.

PubMed ID: 25818041

DOI: 10.1111/epi.12954

Sequence Information:

Length: 451
Mass: 50136
Checksum: 00F8429A4A10E5FE
Sequence:

MRECISIHVG QAGVQIGNAC WELYCLEHGI QPDGQMPSDK TIGGGDDSFN TFFSETGAGK 
HVPRAVFVDL EPTVIDEVRT GTYRQLFHPE QLITGKEDAA NNYARGHYTI GKEIIDLVLD 
RIRKLADQCT GLQGFLVFHS FGGGTGSGFT SLLMERLSVD YGKKSKLEFS IYPAPQVSTA 
VVEPYNSILT THTTLEHSDC AFMVDNEAIY DICRRNLDIE RPTYTNLNRL IGQIVSSITA 
SLRFDGALNV DLTEFQTNLV PYPRIHFPLA TYAPVISAEK AYHEQLSVAE ITNACFEPAN 
QMVKCDPRHG KYMACCLLYR GDVVPKDVNA AIATIKTKRT IQFVDWCPTG FKVGINYQPP 
TVVPGGDLAK VQRAVCMLSN TTAIAEAWAR LDHKFDLMYA KRAFVHWYVG EGMEEGEFSE 
AREDMAALEK DYEEVGVDSV EGEGEEEGEE Y

Database document:

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Details for: TUBA1A

Associated with

Cells (max top 100)

Other Information

Structural features and restricted expression of a human alpha-tubulin gene. PubMed ID: 3839072

Tubulins in the primate retina: evidence that xanthophylls may be endogenous ligands for the paclitaxel-binding site. PubMed ID: 11504633

Complete sequencing and characterization of 21,243 full-length human cDNAs. PubMed ID: 14702039

The finished DNA sequence of human chromosome 12. PubMed ID: 16541075

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Expression of human alpha-tubulin genes: interspecies conservation of 3' untranslated regions. PubMed ID: 6646120

Microtubule dysfunction by posttranslational nitrotyrosination of alpha-tubulin: a nitric oxide-dependent mechanism of cellular injury. PubMed ID: 10339593

Large spectrum of lissencephaly and pachygyria phenotypes resulting from de novo missense mutations in tubulin alpha 1A (TUBA1A). PubMed ID: 17584854

Evolutionary divergence of enzymatic mechanisms for posttranslational polyglycylation. PubMed ID: 19524510

Molecular basis for age-dependent microtubule acetylation by tubulin acetyltransferase. PubMed ID: 24906155

Mitosis. Microtubule detyrosination guides chromosomes during mitosis. PubMed ID: 25908662

Graded control of microtubule severing by tubulin glutamylation. PubMed ID: 26875866

Dual chromatin and cytoskeletal remodeling by SETD2. PubMed ID: 27518565

Alpha-tubulin tyrosination and CLIP-170 phosphorylation regulate the initiation of dynein-driven transport in neurons. PubMed ID: 26972003

Tyrosination of alpha-tubulin controls the initiation of processive dynein-dynactin motility. PubMed ID: 26968983

Vasohibins encode tubulin detyrosinating activity. PubMed ID: 29146869

Structural basis for polyglutamate chain initiation and elongation by TTLL family enzymes. PubMed ID: 32747782

Posttranslational modification of microtubules by the MATCAP detyrosinase. PubMed ID: 35482892

SPACA9 is a lumenal protein of human ciliary singlet and doublet microtubules. PubMed ID: 36191189

Diagnostic yield of genetic testing in epileptic encephalopathy in childhood. PubMed ID: 25818041