GNAQ | ENSG00000156052 | NCBI 2776

Details for: GNAQ

Gene ID: 2776

Symbol: GNAQ

Ensembl ID: ENSG00000156052

Description: G protein subunit alpha q

Associated with

Acetylcholine regulates insulin secretion
(R-HSA-399997)
Adp signalling through p2y purinoceptor 1
(R-HSA-418592)
Cellular responses to mechanical stimuli
(R-HSA-9855142)
Cellular responses to stimuli
(R-HSA-8953897)
Chaperonin-mediated protein folding
(R-HSA-390466)
Cooperation of pdcl (phlp1) and tric/cct in g-protein beta folding
(R-HSA-6814122)
Fatty acids bound to gpr40 (ffar1) regulate insulin secretion
(R-HSA-434316)
Free fatty acids regulate insulin secretion
(R-HSA-400451)
G-protein activation
(R-HSA-202040)
G-protein mediated events
(R-HSA-112040)
G alpha (i) signalling events
(R-HSA-418594)
G alpha (q) signalling events
(R-HSA-416476)
Gpcr downstream signalling
(R-HSA-388396)
Hemostasis
(R-HSA-109582)
High laminar flow shear stress activates signaling by piezo1 and pecam1:cdh5:kdr in endothelial cells
(R-HSA-9856530)
Integration of energy metabolism
(R-HSA-163685)
Metabolism
(R-HSA-1430728)
Metabolism of proteins
(R-HSA-392499)
Opioid signalling
(R-HSA-111885)
Platelet activation, signaling and aggregation
(R-HSA-76002)
Plc beta mediated events
(R-HSA-112043)
Protein folding
(R-HSA-391251)
Regulation of insulin secretion
(R-HSA-422356)
Response of endothelial cells to shear stress
(R-HSA-9860931)
Signal amplification
(R-HSA-392518)
Signaling by gpcr
(R-HSA-372790)
Signal transduction
(R-HSA-162582)
Thrombin signalling through proteinase activated receptors (pars)
(R-HSA-456926)
Thromboxane signalling through tp receptor
(R-HSA-428930)
Turbulent (oscillatory, disturbed) flow shear stress activates signaling by piezo1 and integrins in endothelial cells
(R-HSA-9860927)
Action potential
(GO:0001508)
Adenylate cyclase-activating g protein-coupled receptor signaling pathway
(GO:0007189)
Blood coagulation
(GO:0007596)
Cytoplasm
(GO:0005737)
Entrainment of circadian clock
(GO:0009649)
Enzyme regulator activity
(GO:0030234)
Extracellular exosome
(GO:0070062)
G-protein beta/gamma-subunit complex binding
(GO:0031683)
Glutamate receptor signaling pathway
(GO:0007215)
Golgi apparatus
(GO:0005794)
G protein-coupled acetylcholine receptor signaling pathway
(GO:0007213)
G protein-coupled receptor binding
(GO:0001664)
G protein activity
(GO:0003925)
Gtpase activator activity
(GO:0005096)
Gtpase activity
(GO:0003924)
Gtp binding
(GO:0005525)
Heterotrimeric g-protein complex
(GO:0005834)
Lysosomal membrane
(GO:0005765)
Metal ion binding
(GO:0046872)
Negative regulation of protein kinase activity
(GO:0006469)
Neuropeptide signaling pathway
(GO:0007218)
Nuclear membrane
(GO:0031965)
Phospholipase c-activating dopamine receptor signaling pathway
(GO:0060158)
Phospholipase c-activating g protein-coupled glutamate receptor signaling pathway
(GO:0007206)
Phospholipase c-activating g protein-coupled receptor signaling pathway
(GO:0007200)
Phospholipase c-activating serotonin receptor signaling pathway
(GO:0007208)
Photoreceptor outer segment
(GO:0001750)
Phototransduction, visible light
(GO:0007603)
Plasma membrane
(GO:0005886)
Protein binding
(GO:0005515)
Protein stabilization
(GO:0050821)
Regulation of canonical wnt signaling pathway
(GO:0060828)
Regulation of platelet activation
(GO:0010543)
Response to prostaglandin e
(GO:0034695)
Synapse
(GO:0045202)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: 1.56
Cell Significance Index: 2
Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: 1.55
Cell Significance Index: 2
Cell Name: GABAergic interneuron (CL0011005)
Fold Change: 1.37
Cell Significance Index: 2
Cell Name: hippocampal granule cell (CL0001033)
Fold Change: 1.12
Cell Significance Index: 1
Cell Name: neoplastic cell (CL0001063)
Fold Change: 1.11
Cell Significance Index: 1
Cell Name: transit amplifying cell of small intestine (CL0009012)
Fold Change: 1.1
Cell Significance Index: 1
Cell Name: forebrain neuroblast (CL1000042)
Fold Change: 1.1
Cell Significance Index: 1
Cell Name: lens epithelial cell (CL0002224)
Fold Change: 1.1
Cell Significance Index: 1
Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 1.08
Cell Significance Index: 1
Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: 1.08
Cell Significance Index: 1
Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: 1.08
Cell Significance Index: 1
Cell Name: retinal progenitor cell (CL0002672)
Fold Change: 1.07
Cell Significance Index: 1
Cell Name: indirect pathway medium spiny neuron (CL4023029)
Fold Change: 1.06
Cell Significance Index: 1
Cell Name: small intestine goblet cell (CL1000495)
Fold Change: 1.06
Cell Significance Index: 1
Cell Name: direct pathway medium spiny neuron (CL4023026)
Fold Change: 1.05
Cell Significance Index: 1
Cell Name: cortical interneuron (CL0008031)
Fold Change: 1.04
Cell Significance Index: 1
Cell Name: hippocampal pyramidal neuron (CL1001571)
Fold Change: 1.03
Cell Significance Index: 1
Cell Name: hippocampal astrocyte (CL0002604)
Fold Change: 1.03
Cell Significance Index: 1
Cell Name: leptomeningeal cell (CL0000708)
Fold Change: 1.02
Cell Significance Index: 1
Cell Name: anterior lens cell (CL0002223)
Fold Change: 1.02
Cell Significance Index: 1
Cell Name: secondary lens fiber (CL0002225)
Fold Change: 1.01
Cell Significance Index: 1
Cell Name: ciliary muscle cell (CL1000443)
Fold Change: 1.01
Cell Significance Index: 1
Cell Name: Purkinje cell (CL0000121)
Fold Change: 1
Cell Significance Index: 1
Cell Name: basal cell of urothelium (CL1000486)
Fold Change: 1
Cell Significance Index: 1
Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
Fold Change: 1
Cell Significance Index: 1
Cell Name: tuft cell of small intestine (CL0009080)
Fold Change: 1
Cell Significance Index: 1
Cell Name: endothelial cell of placenta (CL0009092)
Fold Change: 1
Cell Significance Index: 1
Cell Name: astrocyte of the cerebral cortex (CL0002605)
Fold Change: 1
Cell Significance Index: 1
Cell Name: umbrella cell of urothelium (CL4030056)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: L6 intratelencephalic projecting glutamatergic neuron of the primary motor cortex (CL4023050)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: placental villous trophoblast (CL2000060)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: forebrain radial glial cell (CL0013000)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: hippocampal interneuron (CL1001569)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: GABAergic amacrine cell (CL4030027)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: intermediate cell of urothelium (CL4030055)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: cardiac endothelial cell (CL0010008)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: Hofbauer cell (CL3000001)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: astrocyte (CL0000127)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: cerebral cortex neuron (CL0010012)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: sst GABAergic cortical interneuron (CL4023017)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
Fold Change: 0.99
Cell Significance Index: 1
Cell Name: neural cell (CL0002319)
Fold Change: 0.98
Cell Significance Index: 1
Cell Name: cell (CL0000000)
Fold Change: 0.98
Cell Significance Index: 1
Cell Name: neuron (CL0000540)
Fold Change: 0.98
Cell Significance Index: 1
Cell Name: glioblast (CL0000030)
Fold Change: 0.98
Cell Significance Index: 1
Cell Name: oligodendrocyte (CL0000128)
Fold Change: 0.98
Cell Significance Index: 1
Cell Name: epithelial cell of sweat gland (CL1000448)
Fold Change: 0.98
Cell Significance Index: 1
Cell Name: radial glial cell (CL0000681)
Fold Change: 0.98
Cell Significance Index: 1
Cell Name: epidermal cell (CL0000362)
Fold Change: 0.98
Cell Significance Index: 1
Cell Name: cerebellar granule cell (CL0001031)
Fold Change: 0.98
Cell Significance Index: 1
Cell Name: epidermal Langerhans cell (CL0002457)
Fold Change: 0.98
Cell Significance Index: 1
Cell Name: midget ganglion cell of retina (CL4023188)
Fold Change: 0.98
Cell Significance Index: 1
Cell Name: sebaceous gland cell (CL2000021)
Fold Change: 0.98
Cell Significance Index: 1
Cell Name: extravillous trophoblast (CL0008036)
Fold Change: 0.98
Cell Significance Index: 1
Cell Name: OFF midget ganglion cell (CL4033047)
Fold Change: 0.98
Cell Significance Index: 1
Cell Name: centrilobular region hepatocyte (CL0019029)
Fold Change: 0.98
Cell Significance Index: 1
Cell Name: L6 corticothalamic-projecting glutamatergic cortical neuron (CL4023042)
Fold Change: 0.98
Cell Significance Index: 1
Cell Name: VIP GABAergic cortical interneuron (CL4023016)
Fold Change: 0.98
Cell Significance Index: 1
Cell Name: central nervous system macrophage (CL0000878)
Fold Change: 0.98
Cell Significance Index: 1
Cell Name: periportal region hepatocyte (CL0019026)
Fold Change: 0.98
Cell Significance Index: 1
Cell Name: skeletal muscle fibroblast (CL0011027)
Fold Change: 0.98
Cell Significance Index: 1
Cell Name: preadipocyte (CL0002334)
Fold Change: 0.98
Cell Significance Index: 1
Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
Fold Change: 0.98
Cell Significance Index: 1
Cell Name: conjunctival epithelial cell (CL1000432)
Fold Change: 0.98
Cell Significance Index: 1
Cell Name: ON midget ganglion cell (CL4033046)
Fold Change: 0.98
Cell Significance Index: 1
Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: 0.98
Cell Significance Index: 1
Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
Fold Change: 0.98
Cell Significance Index: 1
Cell Name: glutamatergic neuron (CL0000679)
Fold Change: 0.98
Cell Significance Index: 1
Cell Name: kidney capillary endothelial cell (CL1000892)
Fold Change: 0.98
Cell Significance Index: 1
Cell Name: corneal epithelial cell (CL0000575)
Fold Change: 0.98
Cell Significance Index: 1
Cell Name: intratelencephalic-projecting glutamatergic cortical neuron (CL4023008)
Fold Change: 0.98
Cell Significance Index: 1
Cell Name: microglial cell (CL0000129)
Fold Change: 0.98
Cell Significance Index: 1
Cell Name: perivascular cell (CL4033054)
Fold Change: 0.98
Cell Significance Index: 1
Cell Name: chandelier cell (CL4023083)
Fold Change: 0.98
Cell Significance Index: 1
Cell Name: neuroblast (sensu Nematoda and Protostomia) (CL0000338)
Fold Change: 0.98
Cell Significance Index: 1
Cell Name: epithelial cell of proximal tubule (CL0002306)
Fold Change: 0.97
Cell Significance Index: 1
Cell Name: kidney interstitial fibroblast (CL1000692)
Fold Change: 0.97
Cell Significance Index: 1
Cell Name: corneal endothelial cell (CL0000132)
Fold Change: 0.97
Cell Significance Index: 1
Cell Name: inhibitory interneuron (CL0000498)
Fold Change: 0.97
Cell Significance Index: 1
Cell Name: pyramidal neuron (CL0000598)
Fold Change: 0.97
Cell Significance Index: 1
Cell Name: GABAergic neuron (CL0000617)
Fold Change: 0.97
Cell Significance Index: 1
Cell Name: pulmonary alveolar type 2 cell (CL0002063)
Fold Change: 0.97
Cell Significance Index: 1
Cell Name: L2/3 intratelencephalic projecting glutamatergic neuron (CL4030059)
Fold Change: 0.97
Cell Significance Index: 1
Cell Name: L5/6 near-projecting glutamatergic neuron (CL4030067)
Fold Change: 0.97
Cell Significance Index: 1
Cell Name: Merkel cell (CL0000242)
Fold Change: 0.97
Cell Significance Index: 1
Cell Name: luminal hormone-sensing cell of mammary gland (CL4033058)
Fold Change: 0.97
Cell Significance Index: 1
Cell Name: respiratory goblet cell (CL0002370)
Fold Change: 0.97
Cell Significance Index: 1
Cell Name: malignant cell (CL0001064)
Fold Change: 0.97
Cell Significance Index: 1
Cell Name: kidney collecting duct principal cell (CL1001431)
Fold Change: 0.97
Cell Significance Index: 1
Cell Name: renal principal cell (CL0005009)
Fold Change: 0.97
Cell Significance Index: 1
Cell Name: skeletal muscle fiber (CL0008002)
Fold Change: 0.97
Cell Significance Index: 1
Cell Name: intrahepatic cholangiocyte (CL0002538)
Fold Change: 0.97
Cell Significance Index: 1
Cell Name: neural progenitor cell (CL0011020)
Fold Change: 0.97
Cell Significance Index: 1
Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
Fold Change: 0.97
Cell Significance Index: 1
Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
Fold Change: 0.97
Cell Significance Index: 1
Cell Name: epithelial cell of pancreas (CL0000083)
Fold Change: 0.97
Cell Significance Index: 1
Cell Name: subcutaneous adipocyte (CL0002521)
Fold Change: 0.97
Cell Significance Index: 1
Cell Name: kidney collecting duct intercalated cell (CL1001432)
Fold Change: 0.97
Cell Significance Index: 1

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Other Information

Description

**Key Characteristics** 1. **Structure**: GαQ is a G protein subunit composed of three domains: the N-terminal domain, the GTP-binding domain, and the C-terminal domain. 2. **Function**: GαQ is a stimulatory G protein (Gs) that activates adenylate cyclase, leading to increased cAMP levels and subsequent signaling cascades. 3. **Expression**: The GNAQ gene is widely expressed in various cell types, including neurons, glial cells, epithelial cells, and chromaffin cells. 4. **Regulation**: GαQ is regulated by GTP binding and hydrolysis, as well as by interactions with other G proteins and effectors. **Pathways and Functions** 1. **Insulin Secretion**: GαQ is involved in the regulation of insulin secretion in pancreatic beta cells, where it activates adenylate cyclase and increases cAMP levels. 2. **Platelet Activation**: GαQ plays a role in platelet activation and aggregation, where it regulates the phosphorylation of platelet proteins and activation of signaling pathways. 3. **Blood Coagulation**: GαQ is involved in the regulation of blood coagulation, where it interacts with platelet receptors and regulates thrombin signaling. 4. **Circadian Clock**: GαQ is also involved in the regulation of the circadian clock, where it interacts with clock proteins and regulates the expression of circadian genes. 5. **Neurotransmission**: GαQ is involved in neurotransmission, where it regulates the release of neurotransmitters and synaptic plasticity. **Clinical Significance** 1. **Melanoma**: Mutations in the GNAQ gene have been identified in a subset of melanomas, where they lead to the activation of the MAPK/ERK signaling pathway. 2. **Migratory Retinal Hemangioma**: Mutations in the GNAQ gene have also been identified in migratory retinal hemangiomas, where they lead to the activation of the MAPK/ERK signaling pathway. 3. **Neurological Disorders**: GαQ has been implicated in the pathogenesis of various neurological disorders, including Parkinson's disease, Alzheimer's disease, and Huntington's disease. 4. **Cancer**: GαQ has been implicated in the development and progression of various cancers, including breast cancer, lung cancer, and colon cancer. In conclusion, the GNAQ gene plays a critical role in regulating various cellular processes, including insulin secretion, platelet activation, and blood coagulation. Mutations in the GNAQ gene have been associated with several diseases, including melanoma and migratory retinal hemangioma. Further research is needed to fully understand the role of GαQ in human disease and to develop targeted therapies for the treatment of these disorders.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.