Details for: GNAQ
Associated with
Cells (max top 100)
(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)
- Cell Name: Purkinje cell (CL0000121)
Fold Change: 6.67
Marker Score: 225353 - Cell Name: mature microglial cell (CL0002629)
Fold Change: 4.81
Marker Score: 1738 - Cell Name: neuron associated cell (sensu Vertebrata) (CL0000123)
Fold Change: 4.37
Marker Score: 22945 - Cell Name: stellate neuron (CL0000122)
Fold Change: 4.15
Marker Score: 22282 - Cell Name: epithelial cell of lower respiratory tract (CL0002632)
Fold Change: 3.99
Marker Score: 16623 - Cell Name: granule cell (CL0000120)
Fold Change: 3.82
Marker Score: 28814 - Cell Name: mature astrocyte (CL0002627)
Fold Change: 3.75
Marker Score: 2467 - Cell Name: taste receptor cell (CL0000209)
Fold Change: 3.74
Marker Score: 3230 - Cell Name: chromaffin cell (CL0000166)
Fold Change: 3.73
Marker Score: 5254 - Cell Name: cortical cell of adrenal gland (CL0002097)
Fold Change: 3.68
Marker Score: 65382 - Cell Name: oligodendrocyte (CL0000128)
Fold Change: 3.64
Marker Score: 8703 - Cell Name: central nervous system macrophage (CL0000878)
Fold Change: 3.53
Marker Score: 1756 - Cell Name: neuronal brush cell (CL0000555)
Fold Change: 3.51
Marker Score: 11776.5 - Cell Name: macroglial cell (CL0000126)
Fold Change: 3.38
Marker Score: 7767 - Cell Name: astrocyte of the cerebral cortex (CL0002605)
Fold Change: 3.14
Marker Score: 67051 - Cell Name: inhibitory interneuron (CL0000498)
Fold Change: 3.08
Marker Score: 14250 - Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: 3.04
Marker Score: 12716.5 - Cell Name: lens epithelial cell (CL0002224)
Fold Change: 3.03
Marker Score: 3670 - Cell Name: syncytiotrophoblast cell (CL0000525)
Fold Change: 3.01
Marker Score: 2474 - Cell Name: endothelial cell of vascular tree (CL0002139)
Fold Change: 2.98
Marker Score: 4326 - Cell Name: kidney interstitial fibroblast (CL1000692)
Fold Change: 2.97
Marker Score: 5709 - Cell Name: renal principal cell (CL0005009)
Fold Change: 2.92
Marker Score: 2246 - Cell Name: epithelial cell of prostate (CL0002231)
Fold Change: 2.89
Marker Score: 2010 - Cell Name: lung goblet cell (CL1000143)
Fold Change: 2.88
Marker Score: 831 - Cell Name: renal alpha-intercalated cell (CL0005011)
Fold Change: 2.86
Marker Score: 1508 - Cell Name: lactocyte (CL0002325)
Fold Change: 2.86
Marker Score: 45943 - Cell Name: cerebral cortex endothelial cell (CL1001602)
Fold Change: 2.8
Marker Score: 1672 - Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: 2.74
Marker Score: 802 - Cell Name: cerebral cortex neuron (CL0010012)
Fold Change: 2.71
Marker Score: 7728 - Cell Name: brainstem motor neuron (CL2000047)
Fold Change: 2.68
Marker Score: 1559 - Cell Name: basal epithelial cell of prostatic duct (CL0002236)
Fold Change: 2.68
Marker Score: 2376 - Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
Fold Change: 2.61
Marker Score: 2955 - Cell Name: pyramidal neuron (CL0000598)
Fold Change: 2.6
Marker Score: 4373 - Cell Name: sst GABAergic cortical interneuron (CL4023017)
Fold Change: 2.57
Marker Score: 51192.5 - Cell Name: anterior lens cell (CL0002223)
Fold Change: 2.56
Marker Score: 3445 - Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
Fold Change: 2.54
Marker Score: 2743 - Cell Name: sncg GABAergic cortical interneuron (CL4023015)
Fold Change: 2.51
Marker Score: 19269.5 - Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
Fold Change: 2.51
Marker Score: 37553.5 - Cell Name: vip GABAergic cortical interneuron (CL4023016)
Fold Change: 2.51
Marker Score: 95138.5 - Cell Name: vascular leptomeningeal cell (CL4023051)
Fold Change: 2.48
Marker Score: 2853.5 - Cell Name: astrocyte (CL0000127)
Fold Change: 2.44
Marker Score: 2112 - Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
Fold Change: 2.42
Marker Score: 10048 - Cell Name: cerebellar granule cell precursor (CL0002362)
Fold Change: 2.34
Marker Score: 1311 - Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
Fold Change: 2.28
Marker Score: 83968 - Cell Name: CNS interneuron (CL0000402)
Fold Change: 2.27
Marker Score: 1091 - Cell Name: secondary lens fiber (CL0002225)
Fold Change: 2.24
Marker Score: 1308 - Cell Name: parietal epithelial cell (CL1000452)
Fold Change: 2.22
Marker Score: 805 - Cell Name: sympathetic neuron (CL0011103)
Fold Change: 2.21
Marker Score: 731 - Cell Name: corneal epithelial cell (CL0000575)
Fold Change: 2.19
Marker Score: 2417.5 - Cell Name: corneal endothelial cell (CL0000132)
Fold Change: 2.18
Marker Score: 1272 - Cell Name: renal interstitial pericyte (CL1001318)
Fold Change: 2.17
Marker Score: 2069 - Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: 2.17
Marker Score: 8379 - Cell Name: lung macrophage (CL1001603)
Fold Change: 2.16
Marker Score: 2467 - Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
Fold Change: 2.15
Marker Score: 20239 - Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: 2.13
Marker Score: 674 - Cell Name: smooth muscle cell of prostate (CL1000487)
Fold Change: 2.1
Marker Score: 534 - Cell Name: endothelial cell of pericentral hepatic sinusoid (CL0019022)
Fold Change: 2.09
Marker Score: 2242.5 - Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: 2.06
Marker Score: 126854.5 - Cell Name: GABAergic interneuron (CL0011005)
Fold Change: 2.06
Marker Score: 792 - Cell Name: fat cell (CL0000136)
Fold Change: 2.04
Marker Score: 1142 - Cell Name: oligodendrocyte precursor cell (CL0002453)
Fold Change: 2.03
Marker Score: 2515.5 - Cell Name: skeletal muscle satellite stem cell (CL0008011)
Fold Change: 2.03
Marker Score: 2166 - Cell Name: leptomeningeal cell (CL0000708)
Fold Change: 2.02
Marker Score: 999 - Cell Name: endocrine cell (CL0000163)
Fold Change: 2.02
Marker Score: 1043 - Cell Name: type II pneumocyte (CL0002063)
Fold Change: 2.01
Marker Score: 13088 - Cell Name: OFF retinal ganglion cell (CL4023033)
Fold Change: 2
Marker Score: 837 - Cell Name: kidney capillary endothelial cell (CL1000892)
Fold Change: 2
Marker Score: 625 - Cell Name: alveolar type 2 fibroblast cell (CL4028006)
Fold Change: 1.99
Marker Score: 1105 - Cell Name: podocyte (CL0000653)
Fold Change: 1.98
Marker Score: 733 - Cell Name: dopaminergic neuron (CL0000700)
Fold Change: 1.98
Marker Score: 20472 - Cell Name: neuron (CL0000540)
Fold Change: 1.95
Marker Score: 7930 - Cell Name: hepatoblast (CL0005026)
Fold Change: 1.94
Marker Score: 6364 - Cell Name: type I pneumocyte (CL0002062)
Fold Change: 1.91
Marker Score: 2297 - Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
Fold Change: 1.9
Marker Score: 18083.5 - Cell Name: A2 amacrine cell (CL0004219)
Fold Change: 1.89
Marker Score: 599 - Cell Name: secretory cell (CL0000151)
Fold Change: 1.88
Marker Score: 3426 - Cell Name: cardiac neuron (CL0010022)
Fold Change: 1.86
Marker Score: 2318 - Cell Name: skin fibroblast (CL0002620)
Fold Change: 1.85
Marker Score: 480 - Cell Name: L6b glutamatergic cortical neuron (CL4023038)
Fold Change: 1.85
Marker Score: 15894 - Cell Name: GABAergic neuron (CL0000617)
Fold Change: 1.85
Marker Score: 7696 - Cell Name: kidney connecting tubule epithelial cell (CL1000768)
Fold Change: 1.83
Marker Score: 2595 - Cell Name: ciliary muscle cell (CL1000443)
Fold Change: 1.83
Marker Score: 4011.5 - Cell Name: endothelial cell (CL0000115)
Fold Change: 1.82
Marker Score: 1629 - Cell Name: club cell (CL0000158)
Fold Change: 1.8
Marker Score: 2103 - Cell Name: contractile cell (CL0000183)
Fold Change: 1.8
Marker Score: 974 - Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: 1.79
Marker Score: 610 - Cell Name: cholangiocyte (CL1000488)
Fold Change: 1.78
Marker Score: 666 - Cell Name: epithelial cell of proximal tubule (CL0002306)
Fold Change: 1.78
Marker Score: 6316 - Cell Name: foveolar cell of stomach (CL0002179)
Fold Change: 1.78
Marker Score: 11342 - Cell Name: lung ciliated cell (CL1000271)
Fold Change: 1.76
Marker Score: 837 - Cell Name: endothelial cell of uterus (CL0009095)
Fold Change: 1.75
Marker Score: 3501 - Cell Name: renal beta-intercalated cell (CL0002201)
Fold Change: 1.75
Marker Score: 555 - Cell Name: subcutaneous fat cell (CL0002521)
Fold Change: 1.72
Marker Score: 630.5 - Cell Name: epicardial adipocyte (CL1000309)
Fold Change: 1.72
Marker Score: 836 - Cell Name: mucous neck cell (CL0000651)
Fold Change: 1.7
Marker Score: 3869 - Cell Name: retinal ganglion cell (CL0000740)
Fold Change: 1.68
Marker Score: 2093 - Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
Fold Change: 1.62
Marker Score: 1648 - Cell Name: respiratory goblet cell (CL0002370)
Fold Change: 1.62
Marker Score: 469 - Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
Fold Change: 1.62
Marker Score: 90726.5 - Cell Name: conjunctival epithelial cell (CL1000432)
Fold Change: 1.62
Marker Score: 1706
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Other Information
Genular Protein ID: 3816826265
Symbol: GNAQ_HUMAN
Name: Guanine nucleotide-binding protein G(q) subunit alpha
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 8825633
Title: Molecular cloning of human G alpha q cDNA and chromosomal localization of the G alpha q gene (GNAQ) and a processed pseudogene.
PubMed ID: 8825633
PubMed ID: 8664309
Title: Human G(alpha q): cDNA and tissue distribution.
PubMed ID: 8664309
PubMed ID: 8836152
Title: Specificity of G alpha q and G alpha 11 gene expression in platelets and erythrocytes. Expressions of cellular differentiation and species differences.
PubMed ID: 8836152
DOI: 10.1042/bj3181023
PubMed ID: 9700850
Title: G alpha q cDNA sequence from human platelets.
PubMed ID: 9700850
PubMed ID: 15164053
Title: DNA sequence and analysis of human chromosome 9.
PubMed ID: 15164053
DOI: 10.1038/nature02465
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 1333286
Title: Signal-transducing G proteins and antidepressant drugs: evidence for modulation of alpha subunit gene expression in rat brain.
PubMed ID: 1333286
PubMed ID: 7492305
Title: Ca2+ signalling in K562 human erythroleukaemia cells: effect of dimethyl sulphoxide and role of G-proteins in thrombin- and thromboxane A2-activated pathways.
PubMed ID: 7492305
DOI: 10.1042/bj3120151
PubMed ID: 12193606
Title: Regulation of GTP-binding protein alpha q (Galpha q) signaling by the ezrin-radixin-moesin-binding phosphoprotein-50 (EBP50).
PubMed ID: 12193606
PubMed ID: 18672896
Title: Regulation of G protein-coupled receptor activities by the platelet-endothelial cell adhesion molecule, PECAM-1.
PubMed ID: 18672896
DOI: 10.1021/bi8003846
PubMed ID: 19001095
Title: Identification of G protein alpha subunit-palmitoylating enzyme.
PubMed ID: 19001095
DOI: 10.1128/mcb.01144-08
PubMed ID: 21269460
Title: Initial characterization of the human central proteome.
PubMed ID: 21269460
PubMed ID: 21923740
Title: Expression of G protein alphaq subunit is decreased in lymphocytes from rheumatoid arthritis patients and is correlated with disease activity.
PubMed ID: 21923740
PubMed ID: 23994616
Title: A novel Galphas-binding protein, Gas-2 like 2, facilitates the signaling of the A2A adenosine receptor.
PubMed ID: 23994616
PubMed ID: 23656586
Title: Sturge-Weber syndrome and port-wine stains caused by somatic mutation in GNAQ.
PubMed ID: 23656586
PubMed ID: 24141704
Title: A bacterial toxin catalyzing tyrosine glycosylation of Rho and deamidation of Gq and Gi proteins.
PubMed ID: 24141704
DOI: 10.1038/nsmb.2688
PubMed ID: 24275569
Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.
PubMed ID: 24275569
PubMed ID: 25944712
Title: N-terminome analysis of the human mitochondrial proteome.
PubMed ID: 25944712
PubMed ID: 27852822
Title: Targeted Elimination of G Proteins and Arrestins Defines Their Specific Contributions to Both Intensity and Duration of G Protein-coupled Receptor Signaling.
PubMed ID: 27852822
PubMed ID: 19078957
Title: Frequent somatic mutations of GNAQ in uveal melanoma and blue naevi.
PubMed ID: 19078957
DOI: 10.1038/nature07586
PubMed ID: 22307269
Title: GNAQ and GNA11 mutations in melanocytomas of the central nervous system.
PubMed ID: 22307269
Sequence Information:
- Length: 359
- Mass: 42142
- Checksum: 6F69C4F617DFA7C7
- Sequence:
MTLESIMACC LSEEAKEARR INDEIERQLR RDKRDARREL KLLLLGTGES GKSTFIKQMR IIHGSGYSDE DKRGFTKLVY QNIFTAMQAM IRAMDTLKIP YKYEHNKAHA QLVREVDVEK VSAFENPYVD AIKSLWNDPG IQECYDRRRE YQLSDSTKYY LNDLDRVADP AYLPTQQDVL RVRVPTTGII EYPFDLQSVI FRMVDVGGQR SERRKWIHCF ENVTSIMFLV ALSEYDQVLV ESDNENRMEE SKALFRTIIT YPWFQNSSVI LFLNKKDLLE EKIMYSHLVD YFPEYDGPQR DAQAAREFIL KMFVDLNPDS DKIIYSHFTC ATDTENIRFV FAAVKDTILQ LNLKEYNLV
Database document:
This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.