Details for: GNAQ
Associated with
Cells (max top 100)
(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)
- Cell Name: polychromatophilic erythroblast (CL0000550)
Fold Change: 728.6948
Cell Significance Index: -113.3500 - Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
Fold Change: 425.4398
Cell Significance Index: -107.9100 - Cell Name: smooth muscle fiber of ileum (CL1000278)
Fold Change: 249.1937
Cell Significance Index: -117.6500 - Cell Name: peripheral blood mononuclear cell (CL2000001)
Fold Change: 215.7721
Cell Significance Index: -110.9900 - Cell Name: ileal goblet cell (CL1000326)
Fold Change: 175.4339
Cell Significance Index: -117.7200 - Cell Name: orthochromatic erythroblast (CL0000552)
Fold Change: 96.0132
Cell Significance Index: -118.3800 - Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
Fold Change: 42.5573
Cell Significance Index: -114.0100 - Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
Fold Change: 37.3797
Cell Significance Index: -114.8100 - Cell Name: epidermal Langerhans cell (CL0002457)
Fold Change: 34.7302
Cell Significance Index: -76.0100 - Cell Name: stromal cell of bone marrow (CL0010001)
Fold Change: 30.2074
Cell Significance Index: -119.2000 - Cell Name: Purkinje cell (CL0000121)
Fold Change: 5.6256
Cell Significance Index: 123.1800 - Cell Name: retinal progenitor cell (CL0002672)
Fold Change: 4.3384
Cell Significance Index: 243.4500 - Cell Name: hippocampal granule cell (CL0001033)
Fold Change: 3.7592
Cell Significance Index: 252.7700 - Cell Name: forebrain neuroblast (CL1000042)
Fold Change: 3.2438
Cell Significance Index: 199.3800 - Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: 2.8122
Cell Significance Index: 1008.6900 - Cell Name: hippocampal pyramidal neuron (CL1001571)
Fold Change: 2.7904
Cell Significance Index: 79.6300 - Cell Name: cardiac endothelial cell (CL0010008)
Fold Change: 2.7686
Cell Significance Index: 39.8200 - Cell Name: GABAergic amacrine cell (CL4030027)
Fold Change: 2.7059
Cell Significance Index: 33.5600 - Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: 2.5016
Cell Significance Index: 501.8200 - Cell Name: neoplastic cell (CL0001063)
Fold Change: 2.3692
Cell Significance Index: 470.1800 - Cell Name: direct pathway medium spiny neuron (CL4023026)
Fold Change: 2.2389
Cell Significance Index: 84.7800 - Cell Name: indirect pathway medium spiny neuron (CL4023029)
Fold Change: 2.2149
Cell Significance Index: 97.9700 - Cell Name: cortical interneuron (CL0008031)
Fold Change: 2.2087
Cell Significance Index: 52.9700 - Cell Name: GABAergic interneuron (CL0011005)
Fold Change: 2.0562
Cell Significance Index: 1422.1200 - Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
Fold Change: 1.7974
Cell Significance Index: 50.2300 - Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 1.1658
Cell Significance Index: 126.8100 - Cell Name: basal cell of urothelium (CL1000486)
Fold Change: 1.0821
Cell Significance Index: 133.0600 - Cell Name: intermediate cell of urothelium (CL4030055)
Fold Change: 0.8619
Cell Significance Index: 155.3800 - Cell Name: hippocampal astrocyte (CL0002604)
Fold Change: 0.8138
Cell Significance Index: 11.3800 - Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: 0.7945
Cell Significance Index: 1495.8800 - Cell Name: cell in vitro (CL0001034)
Fold Change: 0.7554
Cell Significance Index: 412.5300 - Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: 0.7340
Cell Significance Index: 139.6800 - Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: 0.6811
Cell Significance Index: 432.5500 - Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 0.6067
Cell Significance Index: 98.6700 - Cell Name: tuft cell of colon (CL0009041)
Fold Change: 0.5088
Cell Significance Index: 459.4500 - Cell Name: lens epithelial cell (CL0002224)
Fold Change: 0.5032
Cell Significance Index: 774.7000 - Cell Name: gut absorptive cell (CL0000677)
Fold Change: 0.4102
Cell Significance Index: 24.6300 - Cell Name: stromal cell of ovary (CL0002132)
Fold Change: 0.3160
Cell Significance Index: 43.3900 - Cell Name: cerebellar granule cell (CL0001031)
Fold Change: 0.2620
Cell Significance Index: 4.4900 - Cell Name: anterior lens cell (CL0002223)
Fold Change: 0.2540
Cell Significance Index: 468.4800 - Cell Name: colon goblet cell (CL0009039)
Fold Change: 0.2106
Cell Significance Index: 20.8300 - Cell Name: secondary lens fiber (CL0002225)
Fold Change: 0.1675
Cell Significance Index: 227.8000 - Cell Name: ciliary muscle cell (CL1000443)
Fold Change: 0.0666
Cell Significance Index: 30.2100 - Cell Name: placental villous trophoblast (CL2000060)
Fold Change: -0.0015
Cell Significance Index: -0.0400 - Cell Name: preadipocyte (CL0002334)
Fold Change: -0.0085
Cell Significance Index: -0.1600 - Cell Name: small intestine goblet cell (CL1000495)
Fold Change: -0.0359
Cell Significance Index: -1.2600 - Cell Name: hair follicular keratinocyte (CL2000092)
Fold Change: -0.0445
Cell Significance Index: -19.6700 - Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: -0.0549
Cell Significance Index: -7.9900 - Cell Name: early pro-B cell (CL0002046)
Fold Change: -0.0555
Cell Significance Index: -3.5800 - Cell Name: pulmonary alveolar epithelial cell (CL0000322)
Fold Change: -0.0782
Cell Significance Index: -59.2200 - Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
Fold Change: -0.1020
Cell Significance Index: -74.7900 - Cell Name: pancreatic A cell (CL0000171)
Fold Change: -0.1369
Cell Significance Index: -101.4400 - Cell Name: abnormal cell (CL0001061)
Fold Change: -0.2031
Cell Significance Index: -20.7400 - Cell Name: conjunctival epithelial cell (CL1000432)
Fold Change: -0.2052
Cell Significance Index: -2.8000 - Cell Name: type B pancreatic cell (CL0000169)
Fold Change: -0.2104
Cell Significance Index: -118.6500 - Cell Name: pancreatic PP cell (CL0002275)
Fold Change: -0.2205
Cell Significance Index: -137.7100 - Cell Name: leptomeningeal cell (CL0000708)
Fold Change: -0.3539
Cell Significance Index: -7.5700 - Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: -0.3549
Cell Significance Index: -60.6000 - Cell Name: dopaminergic neuron (CL0000700)
Fold Change: -0.3645
Cell Significance Index: -104.8700 - Cell Name: microfold cell of epithelium of small intestine (CL1000353)
Fold Change: -0.4488
Cell Significance Index: -31.0400 - Cell Name: lactocyte (CL0002325)
Fold Change: -0.4990
Cell Significance Index: -64.4700 - Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: -0.5136
Cell Significance Index: -23.2800 - Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
Fold Change: -0.5333
Cell Significance Index: -25.0600 - Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: -0.5401
Cell Significance Index: -25.1800 - Cell Name: odontoblast (CL0000060)
Fold Change: -0.5628
Cell Significance Index: -72.1500 - Cell Name: epithelial cell of stomach (CL0002178)
Fold Change: -0.5919
Cell Significance Index: -68.9800 - Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: -0.6062
Cell Significance Index: -63.1200 - Cell Name: pancreatic D cell (CL0000173)
Fold Change: -0.6491
Cell Significance Index: -136.7100 - Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: -0.6560
Cell Significance Index: -18.9000 - Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: -0.8219
Cell Significance Index: -94.1600 - Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: -0.9213
Cell Significance Index: -68.6600 - Cell Name: tonsil germinal center B cell (CL2000006)
Fold Change: -0.9645
Cell Significance Index: -113.7400 - Cell Name: endothelial cell of placenta (CL0009092)
Fold Change: -1.0063
Cell Significance Index: -6.0800 - Cell Name: bladder urothelial cell (CL1001428)
Fold Change: -1.1517
Cell Significance Index: -59.8300 - Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: -1.2095
Cell Significance Index: -92.8200 - Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
Fold Change: -1.2646
Cell Significance Index: -100.1600 - Cell Name: transit amplifying cell of small intestine (CL0009012)
Fold Change: -1.4443
Cell Significance Index: -29.9600 - Cell Name: neutrophil progenitor cell (CL0000834)
Fold Change: -1.5073
Cell Significance Index: -40.3200 - Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
Fold Change: -1.5389
Cell Significance Index: -32.7800 - Cell Name: centrilobular region hepatocyte (CL0019029)
Fold Change: -1.6195
Cell Significance Index: -27.2800 - Cell Name: glycinergic neuron (CL1001509)
Fold Change: -1.6622
Cell Significance Index: -87.2700 - Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: -1.6832
Cell Significance Index: -53.9100 - Cell Name: intestinal tuft cell (CL0019032)
Fold Change: -1.7338
Cell Significance Index: -106.3000 - Cell Name: skeletal muscle fiber (CL0008002)
Fold Change: -1.7402
Cell Significance Index: -44.7300 - Cell Name: sebum secreting cell (CL0000317)
Fold Change: -1.7800
Cell Significance Index: -125.8900 - Cell Name: cortical cell of adrenal gland (CL0002097)
Fold Change: -1.7904
Cell Significance Index: -47.9800 - Cell Name: basal cell of prostate epithelium (CL0002341)
Fold Change: -1.9332
Cell Significance Index: -52.6200 - Cell Name: eye photoreceptor cell (CL0000287)
Fold Change: -2.0586
Cell Significance Index: -129.7500 - Cell Name: L6b glutamatergic cortical neuron (CL4023038)
Fold Change: -2.0596
Cell Significance Index: -67.4300 - Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
Fold Change: -2.1150
Cell Significance Index: -67.3600 - Cell Name: enteroendocrine cell of small intestine (CL0009006)
Fold Change: -2.1946
Cell Significance Index: -54.8600 - Cell Name: periportal region hepatocyte (CL0019026)
Fold Change: -2.2500
Cell Significance Index: -33.2100 - Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
Fold Change: -2.2628
Cell Significance Index: -78.6300 - Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
Fold Change: -2.4255
Cell Significance Index: -44.8300 - Cell Name: sst GABAergic cortical interneuron (CL4023017)
Fold Change: -2.4341
Cell Significance Index: -48.1300 - Cell Name: forebrain radial glial cell (CL0013000)
Fold Change: -2.6258
Cell Significance Index: -19.0900 - Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
Fold Change: -2.7124
Cell Significance Index: -95.0200 - Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
Fold Change: -2.7474
Cell Significance Index: -58.3100 - Cell Name: fibroblast of cardiac tissue (CL0002548)
Fold Change: -2.7541
Cell Significance Index: -39.5500 - Cell Name: stratified epithelial cell (CL0000079)
Fold Change: -2.7621
Cell Significance Index: -101.4000
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Other Information
Genular Protein ID: 3816826265
Symbol: GNAQ_HUMAN
Name: Guanine nucleotide-binding protein G(q) subunit alpha
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 8825633
Title: Molecular cloning of human G alpha q cDNA and chromosomal localization of the G alpha q gene (GNAQ) and a processed pseudogene.
PubMed ID: 8825633
PubMed ID: 8664309
Title: Human G(alpha q): cDNA and tissue distribution.
PubMed ID: 8664309
PubMed ID: 8836152
Title: Specificity of G alpha q and G alpha 11 gene expression in platelets and erythrocytes. Expressions of cellular differentiation and species differences.
PubMed ID: 8836152
DOI: 10.1042/bj3181023
PubMed ID: 9700850
Title: G alpha q cDNA sequence from human platelets.
PubMed ID: 9700850
PubMed ID: 15164053
Title: DNA sequence and analysis of human chromosome 9.
PubMed ID: 15164053
DOI: 10.1038/nature02465
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 1333286
Title: Signal-transducing G proteins and antidepressant drugs: evidence for modulation of alpha subunit gene expression in rat brain.
PubMed ID: 1333286
PubMed ID: 7492305
Title: Ca2+ signalling in K562 human erythroleukaemia cells: effect of dimethyl sulphoxide and role of G-proteins in thrombin- and thromboxane A2-activated pathways.
PubMed ID: 7492305
DOI: 10.1042/bj3120151
PubMed ID: 12193606
Title: Regulation of GTP-binding protein alpha q (Galpha q) signaling by the ezrin-radixin-moesin-binding phosphoprotein-50 (EBP50).
PubMed ID: 12193606
PubMed ID: 18672896
Title: Regulation of G protein-coupled receptor activities by the platelet-endothelial cell adhesion molecule, PECAM-1.
PubMed ID: 18672896
DOI: 10.1021/bi8003846
PubMed ID: 19001095
Title: Identification of G protein alpha subunit-palmitoylating enzyme.
PubMed ID: 19001095
DOI: 10.1128/mcb.01144-08
PubMed ID: 21269460
Title: Initial characterization of the human central proteome.
PubMed ID: 21269460
PubMed ID: 21923740
Title: Expression of G protein alphaq subunit is decreased in lymphocytes from rheumatoid arthritis patients and is correlated with disease activity.
PubMed ID: 21923740
PubMed ID: 23994616
Title: A novel Galphas-binding protein, Gas-2 like 2, facilitates the signaling of the A2A adenosine receptor.
PubMed ID: 23994616
PubMed ID: 23656586
Title: Sturge-Weber syndrome and port-wine stains caused by somatic mutation in GNAQ.
PubMed ID: 23656586
PubMed ID: 24141704
Title: A bacterial toxin catalyzing tyrosine glycosylation of Rho and deamidation of Gq and Gi proteins.
PubMed ID: 24141704
DOI: 10.1038/nsmb.2688
PubMed ID: 24275569
Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.
PubMed ID: 24275569
PubMed ID: 25944712
Title: N-terminome analysis of the human mitochondrial proteome.
PubMed ID: 25944712
PubMed ID: 27852822
Title: Targeted Elimination of G Proteins and Arrestins Defines Their Specific Contributions to Both Intensity and Duration of G Protein-coupled Receptor Signaling.
PubMed ID: 27852822
PubMed ID: 37991948
Title: The mechanism of Galphaq regulation of PLCbeta3-catalyzed PIP2 hydrolysis.
PubMed ID: 37991948
PubMed ID: 19078957
Title: Frequent somatic mutations of GNAQ in uveal melanoma and blue naevi.
PubMed ID: 19078957
DOI: 10.1038/nature07586
PubMed ID: 22307269
Title: GNAQ and GNA11 mutations in melanocytomas of the central nervous system.
PubMed ID: 22307269
Sequence Information:
- Length: 359
- Mass: 42142
- Checksum: 6F69C4F617DFA7C7
- Sequence:
MTLESIMACC LSEEAKEARR INDEIERQLR RDKRDARREL KLLLLGTGES GKSTFIKQMR IIHGSGYSDE DKRGFTKLVY QNIFTAMQAM IRAMDTLKIP YKYEHNKAHA QLVREVDVEK VSAFENPYVD AIKSLWNDPG IQECYDRRRE YQLSDSTKYY LNDLDRVADP AYLPTQQDVL RVRVPTTGII EYPFDLQSVI FRMVDVGGQR SERRKWIHCF ENVTSIMFLV ALSEYDQVLV ESDNENRMEE SKALFRTIIT YPWFQNSSVI LFLNKKDLLE EKIMYSHLVD YFPEYDGPQR DAQAAREFIL KMFVDLNPDS DKIIYSHFTC ATDTENIRFV FAAVKDTILQ LNLKEYNLV
Database document:
This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.