Details for: GAS7

Gene ID: 8522

Symbol: GAS7

Ensembl ID: ENSG00000007237

Description: growth arrest specific 7

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 302.2272
    Cell Significance Index: -47.0100
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 184.0379
    Cell Significance Index: -46.6800
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 89.5738
    Cell Significance Index: -36.3900
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 83.9157
    Cell Significance Index: -43.1700
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 38.1198
    Cell Significance Index: -47.0000
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 38.0836
    Cell Significance Index: -36.3600
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 16.4604
    Cell Significance Index: -44.1000
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 14.0113
    Cell Significance Index: -30.6700
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 11.9575
    Cell Significance Index: -47.1900
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: 4.0687
    Cell Significance Index: 79.4100
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 3.6867
    Cell Significance Index: 1322.3600
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 2.8619
    Cell Significance Index: 126.5900
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 2.7538
    Cell Significance Index: 104.2800
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 2.7060
    Cell Significance Index: 122.6600
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 2.6710
    Cell Significance Index: 535.7900
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 2.5615
    Cell Significance Index: 31.6900
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 2.1490
    Cell Significance Index: 30.8600
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 1.8813
    Cell Significance Index: 358.0200
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 1.5715
    Cell Significance Index: 105.6700
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: 1.2764
    Cell Significance Index: 36.4300
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.2651
    Cell Significance Index: 125.1500
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: 1.2399
    Cell Significance Index: 62.6600
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 1.2375
    Cell Significance Index: 855.9300
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 1.0523
    Cell Significance Index: 19.4500
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.9810
    Cell Significance Index: 63.2900
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.9700
    Cell Significance Index: 74.4400
  • Cell Name: L6 intratelencephalic projecting glutamatergic neuron of the primary motor cortex (CL4023050)
    Fold Change: 0.8403
    Cell Significance Index: 11.2100
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.5751
    Cell Significance Index: 93.5400
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 0.4983
    Cell Significance Index: 8.5400
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.3991
    Cell Significance Index: 736.0600
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.3491
    Cell Significance Index: 21.4600
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.3297
    Cell Significance Index: 35.8600
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.2967
    Cell Significance Index: 403.3700
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.2839
    Cell Significance Index: 437.0700
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.2072
    Cell Significance Index: 26.5600
  • Cell Name: L6 corticothalamic-projecting glutamatergic cortical neuron (CL4023042)
    Fold Change: 0.1255
    Cell Significance Index: 1.3900
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.0924
    Cell Significance Index: 50.4500
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.0840
    Cell Significance Index: 2.1000
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.0706
    Cell Significance Index: 4.8900
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.0609
    Cell Significance Index: 26.9200
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.0375
    Cell Significance Index: 1.0800
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0111
    Cell Significance Index: 0.3900
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0006
    Cell Significance Index: -1.1300
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0115
    Cell Significance Index: -2.2800
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0333
    Cell Significance Index: -21.1800
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.0484
    Cell Significance Index: -1.1600
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0547
    Cell Significance Index: -40.0700
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0641
    Cell Significance Index: -48.5200
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0647
    Cell Significance Index: -29.3800
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0703
    Cell Significance Index: -52.1100
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0814
    Cell Significance Index: -50.8500
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.0858
    Cell Significance Index: -5.4100
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0899
    Cell Significance Index: -50.7200
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0993
    Cell Significance Index: -13.6300
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.1197
    Cell Significance Index: -3.4300
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.1260
    Cell Significance Index: -2.7300
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.1378
    Cell Significance Index: -24.8400
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.1419
    Cell Significance Index: -40.8200
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.1701
    Cell Significance Index: -5.5700
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.1815
    Cell Significance Index: -26.3800
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.2222
    Cell Significance Index: -22.7000
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.2305
    Cell Significance Index: -28.3400
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.2441
    Cell Significance Index: -51.4100
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.2652
    Cell Significance Index: -45.2900
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.2653
    Cell Significance Index: -8.4500
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: -0.2828
    Cell Significance Index: -16.9800
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.2904
    Cell Significance Index: -16.3000
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.2951
    Cell Significance Index: -38.1200
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.3034
    Cell Significance Index: -3.3100
  • Cell Name: hippocampal interneuron (CL1001569)
    Fold Change: -0.3242
    Cell Significance Index: -4.2000
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.3604
    Cell Significance Index: -42.5000
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.3753
    Cell Significance Index: -7.4200
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.3910
    Cell Significance Index: -44.8000
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.4061
    Cell Significance Index: -47.3300
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.4248
    Cell Significance Index: -44.2300
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.4656
    Cell Significance Index: -24.4500
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.4661
    Cell Significance Index: -6.6800
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.4815
    Cell Significance Index: -5.7400
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.5120
    Cell Significance Index: -40.5500
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.5377
    Cell Significance Index: -10.8000
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.5624
    Cell Significance Index: -26.4300
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.5649
    Cell Significance Index: -11.9900
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.5684
    Cell Significance Index: -42.3600
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.5969
    Cell Significance Index: -36.6000
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: -0.5974
    Cell Significance Index: -7.4100
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.6031
    Cell Significance Index: -13.0300
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.6086
    Cell Significance Index: -15.1800
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.6915
    Cell Significance Index: -36.0200
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: -0.7042
    Cell Significance Index: -7.5500
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.7137
    Cell Significance Index: -10.7600
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.7220
    Cell Significance Index: -51.0600
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.7305
    Cell Significance Index: -10.7900
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -0.7506
    Cell Significance Index: -16.0500
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.8181
    Cell Significance Index: -42.5000
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.8375
    Cell Significance Index: -26.8300
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.8441
    Cell Significance Index: -23.5900
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.8469
    Cell Significance Index: -29.6700
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.8681
    Cell Significance Index: -23.2200
  • Cell Name: neural cell (CL0002319)
    Fold Change: -0.9356
    Cell Significance Index: -10.9200
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -1.0107
    Cell Significance Index: -43.9500

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Cellular localization:** GAS7 is predominantly expressed in cardiac neurons, anterior lens cells, alveolar type 2 fibroblasts, and specific subtypes of GABAergic cortical interneurons. 2. **Protein binding:** GAS7 interacts with actin filaments, influencing their polymerization and binding dynamics. 3. **Actin filament regulation:** GAS7 modulates actin filament polymerization, which is crucial for cellular structure, morphology, and motility. 4. **Neuronal development:** GAS7's expression in GABAergic cortical interneurons suggests its involvement in neural development and function. **Pathways and Functions:** 1. **Actin filament polymerization:** GAS7 regulates actin filament polymerization, which is essential for cellular structure, morphology, and motility. 2. **Actin filament binding:** GAS7 interacts with actin filaments, influencing their binding dynamics and cellular organization. 3. **Neuronal morphogenesis:** GAS7's expression in GABAergic cortical interneurons highlights its involvement in neural development and morphogenesis. 4. **Cell signaling:** GAS7 may participate in cell signaling pathways, regulating cellular responses to various stimuli. **Clinical Significance:** 1. **Neurological disorders:** GAS7's involvement in GABAergic cortical interneuron development and function suggests its potential role in neurological disorders, such as epilepsy, autism, and schizophrenia. 2. **Cancer:** GAS7's expression in various cancer types, including lung and breast cancer, may indicate its role in tumorigenesis and metastasis. 3. **Cardiac disease:** GAS7's expression in cardiac neurons may contribute to the development of cardiac disease, such as heart failure and cardiomyopathy. 4. **Regenerative medicine:** GAS7's role in actin filament regulation and cell signaling may make it a valuable target for regenerative medicine applications, such as tissue engineering and stem cell therapy. In conclusion, GAS7 is a multifunctional protein that plays a complex role in various cellular processes, including actin filament dynamics, neuronal development, and cell signaling. Its clinical significance extends to neurological disorders, cancer, cardiac disease, and regenerative medicine. Further research is needed to fully elucidate GAS7's functions and potential therapeutic applications.

Genular Protein ID: 1023015963

Symbol: GAS7_HUMAN

Name: Growth arrest-specific protein 7

UniProtKB Accession Codes:

O60861 A8KAC2 B2RCK9 O43144 Q53Y77 Q7Z571

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BMRB 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 4 CDD 2 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 17 Ensembl 7 EvolutionaryTrace 1 ExpressionAtlas 1 GO 7 Gene3D 3 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 8 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 2 PDBsum 2 PRO 1 PROSITE 4 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 4 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 4 RNAct 1 RefSeq 8 SIGNOR 1 SMART 3 SMR 1 STRING 1 SUPFAM 3 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 2 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9455477

Title: Prediction of the coding sequences of unidentified human genes. VIII. 78 new cDNA clones from brain which code for large proteins in vitro.

PubMed ID: 9455477

DOI: 10.1093/dnares/4.5.307

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16625196

Title: DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage.

PubMed ID: 16625196

DOI: 10.1038/nature04689

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 10706619

Title: Detection of leukemia-associated MLL-GAS7 translocation early during chemotherapy with DNA topoisomerase II inhibitors.

PubMed ID: 10706619

DOI: 10.1073/pnas.050397097

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

Sequence Information:

  • Length: 476
  • Mass: 54371
  • Checksum: 57BFB99907652745
  • Sequence:
    • MSGARCRTLY PFSGERHGQG LRFAAGELIT LLQVPDGGWW EGEKEDGLRG WFPASYVQLL 
EKPGMVPPPP GEESQTVILP PGWQSYLSPQ GRRYYVNTTT NETTWERPSS SPGIPASPGS 
HRSSLPPTVN GYHASGTPAH PPETAHMSVR KSTGDSQNLG SSSPSKKQSK ENTITINCVT 
FPHPDTMPEQ QLLKPTEWSY CDYFWADKKD PQGNGTVAGF ELLLQKQLKG KQMQKEMSEF 
IRERIKIEED YAKNLAKLSQ NSLASQEEGS LGEAWAQVKK SLADEAEVHL KFSAKLHSEV 
EKPLMNFREN FKKDMKKCDH HIADLRKQLA SRYASVEKAR KALTERQRDL EMKTQQLEIK 
LSNKTEEDIK KARRKSTQAG DDLMRCVDLY NQAQSKWFEE MVTTTLELER LEVERVEMIR 
QHLCQYTQLR HETDMFNQST VEPVDQLLRK VDPAKDRELW VREHKTGNIR PVDMEI

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.