IQGAP1 | ENSG00000140575 | NCBI 8826

Details for: IQGAP1

Gene ID: 8826

Symbol: IQGAP1

Ensembl ID: ENSG00000140575

Description: IQ motif containing GTPase activating protein 1

Associated with

Cdc42 gtpase cycle
(R-HSA-9013148)
Cell-cell communication
(R-HSA-1500931)
Disease
(R-HSA-1643685)
Diseases of signal transduction by growth factor receptors and second messengers
(R-HSA-5663202)
Glucagon-like peptide-1 (glp1) regulates insulin secretion
(R-HSA-381676)
Immune system
(R-HSA-168256)
Innate immune system
(R-HSA-168249)
Integration of energy metabolism
(R-HSA-163685)
Map2k and mapk activation
(R-HSA-5674135)
Mapk1/mapk3 signaling
(R-HSA-5684996)
Mapk family signaling cascades
(R-HSA-5683057)
Metabolism
(R-HSA-1430728)
Nephrin family interactions
(R-HSA-373753)
Neutrophil degranulation
(R-HSA-6798695)
Oncogenic mapk signaling
(R-HSA-6802957)
Paradoxical activation of raf signaling by kinase inactive braf
(R-HSA-6802955)
Rac1 gtpase cycle
(R-HSA-9013149)
Rac2 gtpase cycle
(R-HSA-9013404)
Raf/map kinase cascade
(R-HSA-5673001)
Regulation of insulin secretion
(R-HSA-422356)
Rhoa gtpase cycle
(R-HSA-8980692)
Rhoc gtpase cycle
(R-HSA-9013106)
Rho gtpase cycle
(R-HSA-9012999)
Rho gtpase effectors
(R-HSA-195258)
Rho gtpases activate iqgaps
(R-HSA-5626467)
Rhoq gtpase cycle
(R-HSA-9013406)
Rhou gtpase cycle
(R-HSA-9013420)
Rhov gtpase cycle
(R-HSA-9013424)
Signaling by braf and raf1 fusions
(R-HSA-6802952)
Signaling by high-kinase activity braf mutants
(R-HSA-6802948)
Signaling by moderate kinase activity braf mutants
(R-HSA-6802946)
Signaling by raf1 mutants
(R-HSA-9656223)
Signaling by ras mutants
(R-HSA-6802949)
Signaling by rho gtpases
(R-HSA-194315)
Signaling by rho gtpases, miro gtpases and rhobtb3
(R-HSA-9716542)
Signaling downstream of ras mutants
(R-HSA-9649948)
Actin cytoskeleton
(GO:0015629)
Actin filament
(GO:0005884)
Actin filament binding
(GO:0051015)
Apical plasma membrane
(GO:0016324)
Axon
(GO:0030424)
Basolateral plasma membrane
(GO:0016323)
Cadherin binding
(GO:0045296)
Calcium ion binding
(GO:0005509)
Calmodulin binding
(GO:0005516)
Caveola assembly
(GO:0070836)
Cell cortex
(GO:0005938)
Cell migration
(GO:0016477)
Cellular response to calcium ion
(GO:0071277)
Cellular response to epidermal growth factor stimulus
(GO:0071364)
Cellular response to platelet-derived growth factor stimulus
(GO:0036120)
Cortical actin cytoskeleton
(GO:0030864)
Cytoplasm
(GO:0005737)
Cytoplasmic ribonucleoprotein granule
(GO:0036464)
Cytoplasmic side of plasma membrane
(GO:0009898)
Cytosol
(GO:0005829)
Epidermal growth factor receptor signaling pathway
(GO:0007173)
Extracellular exosome
(GO:0070062)
Fibroblast growth factor receptor signaling pathway
(GO:0008543)
Fibroblast migration
(GO:0010761)
Focal adhesion
(GO:0005925)
Growth cone
(GO:0030426)
Gtpase activator activity
(GO:0005096)
Gtpase inhibitor activity
(GO:0005095)
Lateral plasma membrane
(GO:0016328)
Map-kinase scaffold activity
(GO:0005078)
Mapk cascade
(GO:0000165)
Microtubule
(GO:0005874)
Microtubule cytoskeleton
(GO:0015630)
Midbody
(GO:0030496)
Mitotic actomyosin contractile ring assembly actin filament organization
(GO:1903479)
Molecular adaptor activity
(GO:0060090)
Negative regulation of dephosphorylation
(GO:0035305)
Neuron projection
(GO:0043005)
Neuron projection extension
(GO:1990138)
Nucleus
(GO:0005634)
Phosphatidylinositol-3,4,5-trisphosphate binding
(GO:0005547)
Plasma membrane
(GO:0005886)
Platelet-derived growth factor receptor signaling pathway
(GO:0048008)
Podocyte development
(GO:0072015)
Positive regulation of mapk cascade
(GO:0043410)
Positive regulation of protein kinase activity
(GO:0045860)
Protein binding
(GO:0005515)
Protein domain specific binding
(GO:0019904)
Protein kinase binding
(GO:0019901)
Protein phosphatase binding
(GO:0019903)
Protein serine/threonine kinase activator activity
(GO:0043539)
Regulation of cytokine production
(GO:0001817)
Regulation of mitotic cell cycle
(GO:0007346)
Ruffle
(GO:0001726)
S100 protein binding
(GO:0044548)
Secretory granule membrane
(GO:0030667)
Signal transduction
(GO:0007165)
Slit diaphragm
(GO:0036057)
Small gtpase binding
(GO:0031267)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: polychromatophilic erythroblast (CL0000550)
Fold Change: 535.5999
Cell Significance Index: -83.3100
Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
Fold Change: 322.6972
Cell Significance Index: -81.8500
Cell Name: mucosal type mast cell (CL0000485)
Fold Change: 187.2829
Cell Significance Index: -76.0900
Cell Name: smooth muscle fiber of ileum (CL1000278)
Fold Change: 182.7279
Cell Significance Index: -86.2700
Cell Name: peripheral blood mononuclear cell (CL2000001)
Fold Change: 163.8072
Cell Significance Index: -84.2600
Cell Name: ileal goblet cell (CL1000326)
Fold Change: 128.7439
Cell Significance Index: -86.3900
Cell Name: ciliated cell of the bronchus (CL0002332)
Fold Change: 81.0951
Cell Significance Index: -77.4300
Cell Name: orthochromatic erythroblast (CL0000552)
Fold Change: 68.0316
Cell Significance Index: -83.8800
Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
Fold Change: 28.7174
Cell Significance Index: -76.9300
Cell Name: epidermal Langerhans cell (CL0002457)
Fold Change: 24.2348
Cell Significance Index: -53.0400
Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
Fold Change: 23.7868
Cell Significance Index: -73.0600
Cell Name: stromal cell of bone marrow (CL0010001)
Fold Change: 21.4645
Cell Significance Index: -84.7000
Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
Fold Change: 5.0664
Cell Significance Index: 93.6400
Cell Name: placental villous trophoblast (CL2000060)
Fold Change: 4.1930
Cell Significance Index: 111.9600
Cell Name: lung endothelial cell (CL1001567)
Fold Change: 3.4313
Cell Significance Index: 178.7300
Cell Name: early pro-B cell (CL0002046)
Fold Change: 3.3935
Cell Significance Index: 218.9300
Cell Name: intermediate cell of urothelium (CL4030055)
Fold Change: 2.3475
Cell Significance Index: 423.1900
Cell Name: skeletal muscle fiber (CL0008002)
Fold Change: 2.2805
Cell Significance Index: 58.6200
Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 2.2309
Cell Significance Index: 242.6500
Cell Name: preadipocyte (CL0002334)
Fold Change: 2.1699
Cell Significance Index: 42.3500
Cell Name: basal cell of urothelium (CL1000486)
Fold Change: 2.1486
Cell Significance Index: 264.1900
Cell Name: peg cell (CL4033014)
Fold Change: 1.7140
Cell Significance Index: 39.6000
Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
Fold Change: 1.6890
Cell Significance Index: 79.3800
Cell Name: basal cell of prostate epithelium (CL0002341)
Fold Change: 1.5588
Cell Significance Index: 42.4300
Cell Name: hair follicular keratinocyte (CL2000092)
Fold Change: 1.5125
Cell Significance Index: 668.7100
Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: 1.4670
Cell Significance Index: 294.2800
Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: 1.4145
Cell Significance Index: 65.9500
Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 1.1591
Cell Significance Index: 188.5100
Cell Name: cell in vitro (CL0001034)
Fold Change: 1.1209
Cell Significance Index: 612.1300
Cell Name: stromal cell of ovary (CL0002132)
Fold Change: 1.0704
Cell Significance Index: 147.0000
Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: 1.0543
Cell Significance Index: 80.9100
Cell Name: umbrella cell of urothelium (CL4030056)
Fold Change: 0.9898
Cell Significance Index: 9.1200
Cell Name: enteroendocrine cell of small intestine (CL0009006)
Fold Change: 0.9721
Cell Significance Index: 24.3000
Cell Name: tonsil germinal center B cell (CL2000006)
Fold Change: 0.9608
Cell Significance Index: 113.3100
Cell Name: type I muscle cell (CL0002211)
Fold Change: 0.8433
Cell Significance Index: 20.5800
Cell Name: GABAergic interneuron (CL0011005)
Fold Change: 0.7953
Cell Significance Index: 550.0800
Cell Name: lactocyte (CL0002325)
Fold Change: 0.7707
Cell Significance Index: 99.5700
Cell Name: bladder urothelial cell (CL1001428)
Fold Change: 0.6741
Cell Significance Index: 35.0200
Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
Fold Change: 0.6605
Cell Significance Index: 18.4600
Cell Name: cardiac endothelial cell (CL0010008)
Fold Change: 0.6515
Cell Significance Index: 9.3700
Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 0.5914
Cell Significance Index: 17.0400
Cell Name: colon goblet cell (CL0009039)
Fold Change: 0.5275
Cell Significance Index: 52.1800
Cell Name: fibroblast of mammary gland (CL0002555)
Fold Change: 0.5257
Cell Significance Index: 15.0700
Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: 0.5040
Cell Significance Index: 180.7700
Cell Name: neoplastic cell (CL0001063)
Fold Change: 0.4759
Cell Significance Index: 94.4400
Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: 0.4294
Cell Significance Index: 32.0000
Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: 0.3315
Cell Significance Index: 63.0800
Cell Name: sebum secreting cell (CL0000317)
Fold Change: 0.3180
Cell Significance Index: 22.4900
Cell Name: ciliary muscle cell (CL1000443)
Fold Change: 0.1510
Cell Significance Index: 68.5300
Cell Name: endothelial cell of placenta (CL0009092)
Fold Change: 0.1308
Cell Significance Index: 0.7900
Cell Name: odontoblast (CL0000060)
Fold Change: 0.1292
Cell Significance Index: 16.5600
Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: 0.1281
Cell Significance Index: 21.8700
Cell Name: small intestine goblet cell (CL1000495)
Fold Change: 0.1010
Cell Significance Index: 3.5500
Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: 0.0748
Cell Significance Index: 3.3900
Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: 0.0543
Cell Significance Index: 102.2400
Cell Name: lens epithelial cell (CL0002224)
Fold Change: 0.0391
Cell Significance Index: 60.2400
Cell Name: anterior lens cell (CL0002223)
Fold Change: 0.0352
Cell Significance Index: 64.9600
Cell Name: pulmonary alveolar epithelial cell (CL0000322)
Fold Change: 0.0309
Cell Significance Index: 23.4200
Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: -0.0017
Cell Significance Index: -1.1000
Cell Name: pancreatic A cell (CL0000171)
Fold Change: -0.0233
Cell Significance Index: -17.2600
Cell Name: secondary lens fiber (CL0002225)
Fold Change: -0.0246
Cell Significance Index: -33.5100
Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
Fold Change: -0.0319
Cell Significance Index: -23.3800
Cell Name: abnormal cell (CL0001061)
Fold Change: -0.0607
Cell Significance Index: -6.2000
Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
Fold Change: -0.0662
Cell Significance Index: -1.9500
Cell Name: pancreatic PP cell (CL0002275)
Fold Change: -0.0767
Cell Significance Index: -47.9000
Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: -0.0907
Cell Significance Index: -13.1900
Cell Name: type B pancreatic cell (CL0000169)
Fold Change: -0.0953
Cell Significance Index: -53.7200
Cell Name: forebrain neuroblast (CL1000042)
Fold Change: -0.1536
Cell Significance Index: -9.4400
Cell Name: pancreatic D cell (CL0000173)
Fold Change: -0.2106
Cell Significance Index: -44.3600
Cell Name: dopaminergic neuron (CL0000700)
Fold Change: -0.2563
Cell Significance Index: -73.7400
Cell Name: pancreatic endocrine cell (CL0008024)
Fold Change: -0.2657
Cell Significance Index: -30.3300
Cell Name: epithelial cell of stomach (CL0002178)
Fold Change: -0.4183
Cell Significance Index: -48.7500
Cell Name: neutrophil progenitor cell (CL0000834)
Fold Change: -0.4236
Cell Significance Index: -11.3300
Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: -0.4356
Cell Significance Index: -49.9100
Cell Name: fibro/adipogenic progenitor cell (CL0009099)
Fold Change: -0.4802
Cell Significance Index: -24.2700
Cell Name: retinal progenitor cell (CL0002672)
Fold Change: -0.5444
Cell Significance Index: -30.5500
Cell Name: leptomeningeal cell (CL0000708)
Fold Change: -0.5722
Cell Significance Index: -12.2300
Cell Name: conjunctival epithelial cell (CL1000432)
Fold Change: -0.5750
Cell Significance Index: -7.8500
Cell Name: paneth cell of epithelium of small intestine (CL1000343)
Fold Change: -0.6561
Cell Significance Index: -14.2200
Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: -0.6705
Cell Significance Index: -69.8200
Cell Name: granulosa cell (CL0000501)
Fold Change: -0.7427
Cell Significance Index: -19.5300
Cell Name: hippocampal granule cell (CL0001033)
Fold Change: -0.7647
Cell Significance Index: -51.4200
Cell Name: cortical cell of adrenal gland (CL0002097)
Fold Change: -0.9214
Cell Significance Index: -24.6900
Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
Fold Change: -0.9799
Cell Significance Index: -77.6100
Cell Name: indirect pathway medium spiny neuron (CL4023029)
Fold Change: -0.9893
Cell Significance Index: -43.7600
Cell Name: fibroblast of cardiac tissue (CL0002548)
Fold Change: -1.1964
Cell Significance Index: -17.1800
Cell Name: eye photoreceptor cell (CL0000287)
Fold Change: -1.2888
Cell Significance Index: -81.2300
Cell Name: direct pathway medium spiny neuron (CL4023026)
Fold Change: -1.2913
Cell Significance Index: -48.9000
Cell Name: intestinal tuft cell (CL0019032)
Fold Change: -1.3951
Cell Significance Index: -85.5400
Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: -1.4258
Cell Significance Index: -45.6700
Cell Name: glycinergic neuron (CL1001509)
Fold Change: -1.6540
Cell Significance Index: -86.8400
Cell Name: pro-T cell (CL0000827)
Fold Change: -1.7321
Cell Significance Index: -44.2500
Cell Name: mesenchymal cell (CL0008019)
Fold Change: -1.8239
Cell Significance Index: -30.5300
Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
Fold Change: -1.8251
Cell Significance Index: -63.4200
Cell Name: stratified epithelial cell (CL0000079)
Fold Change: -1.8723
Cell Significance Index: -68.7300
Cell Name: L6b glutamatergic cortical neuron (CL4023038)
Fold Change: -1.9004
Cell Significance Index: -62.2200
Cell Name: vascular lymphangioblast (CL0005022)
Fold Change: -1.9056
Cell Significance Index: -33.6800
Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
Fold Change: -1.9574
Cell Significance Index: -62.3400
Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
Fold Change: -1.9628
Cell Significance Index: -68.7600
Cell Name: luminal hormone-sensing cell of mammary gland (CL4033058)
Fold Change: -1.9962
Cell Significance Index: -12.2900

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

**Key Characteristics:** 1. **Scaffold function:** IQGAP1 serves as a molecular scaffold, binding to multiple signaling proteins and modulating their activity. 2. **GTPase activating protein (GAP) activity:** IQGAP1 possesses GAP activity, which regulates the activity of small GTPases, including Ras, Rho, and Rac. 3. **Cytoskeletal organization:** IQGAP1 regulates cytoskeletal dynamics, influencing the organization of actin filaments and microtubules. 4. **Cell signaling:** IQGAP1 modulates signaling pathways, including those involved in cell migration, proliferation, and differentiation. **Pathways and Functions:** 1. **Rho GTPase pathway:** IQGAP1 regulates the activity of Rho GTPases, which are involved in cell migration, adhesion, and cytoskeletal organization. 2. **MAPK signaling pathway:** IQGAP1 interacts with MAPK kinases and modulates the activity of the MAPK cascade, influencing cell proliferation, differentiation, and survival. 3. **Actin cytoskeleton organization:** IQGAP1 regulates the organization of actin filaments, influencing cell shape, migration, and adhesion. 4. **Immune response:** IQGAP1 is expressed in immune cells and plays a role in regulating immune responses, including cytokine production and neutrophil degranulation. **Clinical Significance:** 1. **Cancer:** IQGAP1 dysregulation has been implicated in various cancers, including breast, lung, and colon cancer. 2. **Autoimmune disorders:** IQGAP1 dysfunction has been linked to autoimmune diseases, such as rheumatoid arthritis and multiple sclerosis. 3. **Metabolic disorders:** IQGAP1 regulation of insulin signaling and glucose metabolism has been implicated in metabolic disorders, including type 2 diabetes. 4. **Neurological disorders:** IQGAP1 dysregulation has been linked to neurological disorders, including Alzheimer's disease and Parkinson's disease. In conclusion, IQGAP1 is a multifunctional gene that plays a crucial role in regulating cytoskeletal dynamics, cell signaling, and immune response. Its dysregulation has been implicated in various diseases, highlighting the importance of IQGAP1 in maintaining cellular homeostasis and overall health. Further research is needed to fully elucidate the mechanisms by which IQGAP1 regulates cellular processes and to explore its therapeutic potential in disease treatment.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

Ras GTPase-activating-like protein IQGAP1

Genular Protein ID: 3496324890

Symbol: IQGA1_HUMAN

Name: Ras GTPase-activating-like protein IQGAP1

UniProtKB Accession Codes:

P46940 A7MBM3

Database IDs:

Citations:

PubMed ID: 8051149

Title: Identification of a human rasGAP-related protein containing calmodulin-binding motifs.

PubMed ID: 8051149

DOI: 10.1016/s0021-9258(17)32023-9

PubMed ID: 7584044

Title: Prediction of the coding sequences of unidentified human genes. II. The coding sequences of 40 new genes (KIAA0041-KIAA0080) deduced by analysis of cDNA clones from human cell line KG-1.

PubMed ID: 7584044

DOI: 10.1093/dnares/1.5.223

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 15355962

Title: Phosphorylation of IQGAP1 modulates its binding to Cdc42, revealing a new type of rho-GTPase regulator.

PubMed ID: 15355962

DOI: 10.1074/jbc.m408113200

PubMed ID: 15695813

Title: IQGAP1 promotes neurite outgrowth in a phosphorylation-dependent manner.

PubMed ID: 15695813

DOI: 10.1074/jbc.m413482200

PubMed ID: 8670801

Title: IQGAP1, a calmodulin-binding protein with a rasGAP-related domain, is a potential effector for cdc42Hs.

PubMed ID: 8670801

DOI: 10.1002/j.1460-2075.1996.tb00663.x

PubMed ID: 17081983

Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.

PubMed ID: 17081983

DOI: 10.1016/j.cell.2006.09.026

PubMed ID: 17853893

Title: Human ESCRT and ALIX proteins interact with proteins of the midbody and function in cytokinesis.

PubMed ID: 17853893

DOI: 10.1038/sj.emboj.7601850

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 18642328

Title: Increased PAK6 expression in prostate cancer and identification of PAK6 associated proteins.

PubMed ID: 18642328

DOI: 10.1002/pros.20787

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 20883816

Title: IQGAP1 translocates to the nucleus in early S-phase and contributes to cell cycle progression after DNA replication arrest.

PubMed ID: 20883816

DOI: 10.1016/j.biocel.2010.09.014

PubMed ID: 22223895

Title: Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features.

PubMed ID: 22223895

DOI: 10.1074/mcp.m111.015131

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 23333244

Title: SASH1 regulates melanocyte transepithelial migration through a novel Galphas-SASH1-IQGAP1-E-cadherin dependent pathway.

PubMed ID: 23333244

DOI: 10.1016/j.cellsig.2012.12.025

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 23637409

Title: Host IQGAP1 and Ebola virus VP40 interactions facilitate virus-like particle egress.

PubMed ID: 23637409

DOI: 10.1128/jvi.00470-13

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 29033352

Title: The primate-specific gene TMEM14B marks outer radial glia cells and promotes cortical expansion and folding.

PubMed ID: 29033352

DOI: 10.1016/j.stem.2017.08.013

PubMed ID: 31739185

Title: Characterization of pUL5, an HCMV protein interacting with the cellular protein IQGAP1.

PubMed ID: 31739185

DOI: 10.1016/j.virol.2019.10.018

PubMed ID: 33637714

Title: The Campylobacter jejuni CiaD effector co-opts the host cell protein IQGAP1 to promote cell entry.

PubMed ID: 33637714

DOI: 10.1038/s41467-021-21579-5

PubMed ID: 35601831

Title: Identification of IQGAP1 as a SLC26A4 (Pendrin)-Binding Protein in the Kidney.

PubMed ID: 35601831

DOI: 10.3389/fmolb.2022.874186

Sequence Information:

Length: 1657
Mass: 189252
Checksum: A52EC629596EAC33
Sequence:

MSAADEVDGL GVARPHYGSV LDNERLTAEE MDERRRQNVA YEYLCHLEEA KRWMEACLGE 
DLPPTTELEE GLRNGVYLAK LGNFFSPKVV SLKKIYDREQ TRYKATGLHF RHTDNVIQWL 
NAMDEIGLPK IFYPETTDIY DRKNMPRCIY CIHALSLYLF KLGLAPQIQD LYGKVDFTEE 
EINNMKTELE KYGIQMPAFS KIGGILANEL SVDEAALHAA VIAINEAIDR RIPADTFAAL 
KNPNAMLVNL EEPLASTYQD ILYQAKQDKM TNAKNRTENS ERERDVYEEL LTQAEIQGNI 
NKVNTFSALA NIDLALEQGD ALALFRALQS PALGLRGLQQ QNSDWYLKQL LSDKQQKRQS 
GQTDPLQKEE LQSGVDAANS AAQQYQRRLA AVALINAAIQ KGVAEKTVLE LMNPEAQLPQ 
VYPFAADLYQ KELATLQRQS PEHNLTHPEL SVAVEMLSSV ALINRALESG DVNTVWKQLS 
SSVTGLTNIE EENCQRYLDE LMKLKAQAHA ENNEFITWND IQACVDHVNL VVQEEHERIL 
AIGLINEALD EGDAQKTLQA LQIPAAKLEG VLAEVAQHYQ DTLIRAKREK AQEIQDESAV 
LWLDEIQGGI WQSNKDTQEA QKFALGIFAI NEAVESGDVG KTLSALRSPD VGLYGVIPEC 
GETYHSDLAE AKKKKLAVGD NNSKWVKHWV KGGYYYYHNL ETQEGGWDEP PNFVQNSMQL 
SREEIQSSIS GVTAAYNREQ LWLANEGLIT RLQARCRGYL VRQEFRSRMN FLKKQIPAIT 
CIQSQWRGYK QKKAYQDRLA YLRSHKDEVV KIQSLARMHQ ARKRYRDRLQ YFRDHINDII 
KIQAFIRANK ARDDYKTLIN AEDPPMVVVR KFVHLLDQSD QDFQEELDLM KMREEVITLI 
RSNQQLENDL NLMDIKIGLL VKNKITLQDV VSHSKKLTKK NKEQLSDMMM INKQKGGLKA 
LSKEKREKLE AYQHLFYLLQ TNPTYLAKLI FQMPQNKSTK FMDSVIFTLY NYASNQREEY 
LLLRLFKTAL QEEIKSKVDQ IQEIVTGNPT VIKMVVSFNR GARGQNALRQ ILAPVVKEIM 
DDKSLNIKTD PVDIYKSWVN QMESQTGEAS KLPYDVTPEQ ALAHEEVKTR LDSSIRNMRA 
VTDKFLSAIV SSVDKIPYGM RFIAKVLKDS LHEKFPDAGE DELLKIIGNL LYYRYMNPAI 
VAPDAFDIID LSAGGQLTTD QRRNLGSIAK MLQHAASNKM FLGDNAHLSI INEYLSQSYQ 
KFRRFFQTAC DVPELQDKFN VDEYSDLVTL TKPVIYISIG EIINTHTLLL DHQDAIAPEH 
NDPIHELLDD LGEVPTIESL IGESSGNLND PNKEALAKTE VSLTLTNKFD VPGDENAEMD 
ARTILLNTKR LIVDVIRFQP GETLTEILET PATSEQEAEH QRAMQRRAIR DAKTPDKMKK 
SKSVKEDSNL TLQEKKEKIQ TGLKKLTELG TVDPKNKYQE LINDIARDIR NQRRYRQRRK 
AELVKLQQTY AALNSKATFY GEQVDYYKSY IKTCLDNLAS KGKVSKKPRE MKGKKSKKIS 
LKYTAARLHE KGVLLEIEDL QVNQFKNVIF EISPTEEVGD FEVKAKFMGV QMETFMLHYQ 
DLLQLQYEGV AVMKLFDRAK VNVNLLIFLL NKKFYGK

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: IQGAP1

Associated with

Cells (max top 100)

Other Information

Identification of a human rasGAP-related protein containing calmodulin-binding motifs. PubMed ID: 8051149

Prediction of the coding sequences of unidentified human genes. II. The coding sequences of 40 new genes (KIAA0041-KIAA0080) deduced by analysis of cDNA clones from human cell line KG-1. PubMed ID: 7584044

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Phosphorylation of IQGAP1 modulates its binding to Cdc42, revealing a new type of rho-GTPase regulator. PubMed ID: 15355962

IQGAP1 promotes neurite outgrowth in a phosphorylation-dependent manner. PubMed ID: 15695813

IQGAP1, a calmodulin-binding protein with a rasGAP-related domain, is a potential effector for cdc42Hs. PubMed ID: 8670801

Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. PubMed ID: 17081983

Human ESCRT and ALIX proteins interact with proteins of the midbody and function in cytokinesis. PubMed ID: 17853893

A quantitative atlas of mitotic phosphorylation. PubMed ID: 18669648

Increased PAK6 expression in prostate cancer and identification of PAK6 associated proteins. PubMed ID: 18642328

Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. PubMed ID: 20068231

Initial characterization of the human central proteome. PubMed ID: 21269460

IQGAP1 translocates to the nucleus in early S-phase and contributes to cell cycle progression after DNA replication arrest. PubMed ID: 20883816

Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features. PubMed ID: 22223895

N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB. PubMed ID: 22814378

SASH1 regulates melanocyte transepithelial migration through a novel Galphas-SASH1-IQGAP1-E-cadherin dependent pathway. PubMed ID: 23333244

Toward a comprehensive characterization of a human cancer cell phosphoproteome. PubMed ID: 23186163

Host IQGAP1 and Ebola virus VP40 interactions facilitate virus-like particle egress. PubMed ID: 23637409

An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. PubMed ID: 24275569

N-terminome analysis of the human mitochondrial proteome. PubMed ID: 25944712

The primate-specific gene TMEM14B marks outer radial glia cells and promotes cortical expansion and folding. PubMed ID: 29033352

Characterization of pUL5, an HCMV protein interacting with the cellular protein IQGAP1. PubMed ID: 31739185

The Campylobacter jejuni CiaD effector co-opts the host cell protein IQGAP1 to promote cell entry. PubMed ID: 33637714

Identification of IQGAP1 as a SLC26A4 (Pendrin)-Binding Protein in the Kidney. PubMed ID: 35601831